-- dump date 20140619_010329 -- class Genbank::misc_feature -- table misc_feature_note -- id note 483179000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 483179000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 483179000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 483179000004 Walker A motif; other site 483179000005 ATP binding site [chemical binding]; other site 483179000006 Walker B motif; other site 483179000007 arginine finger; other site 483179000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 483179000009 DnaA box-binding interface [nucleotide binding]; other site 483179000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 483179000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 483179000012 putative DNA binding surface [nucleotide binding]; other site 483179000013 dimer interface [polypeptide binding]; other site 483179000014 beta-clamp/clamp loader binding surface; other site 483179000015 beta-clamp/translesion DNA polymerase binding surface; other site 483179000016 recombination protein F; Reviewed; Region: recF; PRK00064 483179000017 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 483179000018 Walker A/P-loop; other site 483179000019 ATP binding site [chemical binding]; other site 483179000020 Q-loop/lid; other site 483179000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483179000022 ABC transporter signature motif; other site 483179000023 Walker B; other site 483179000024 D-loop; other site 483179000025 H-loop/switch region; other site 483179000026 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 483179000027 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 483179000028 ATP binding site [chemical binding]; other site 483179000029 substrate interface [chemical binding]; other site 483179000030 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 483179000031 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 483179000032 putative ligand binding site [chemical binding]; other site 483179000033 NAD binding site [chemical binding]; other site 483179000034 dimerization interface [polypeptide binding]; other site 483179000035 catalytic site [active] 483179000036 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 483179000037 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 483179000038 Walker A/P-loop; other site 483179000039 ATP binding site [chemical binding]; other site 483179000040 Q-loop/lid; other site 483179000041 ABC transporter signature motif; other site 483179000042 Walker B; other site 483179000043 D-loop; other site 483179000044 H-loop/switch region; other site 483179000045 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 483179000046 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 483179000047 Walker A/P-loop; other site 483179000048 ATP binding site [chemical binding]; other site 483179000049 Q-loop/lid; other site 483179000050 ABC transporter signature motif; other site 483179000051 Walker B; other site 483179000052 D-loop; other site 483179000053 H-loop/switch region; other site 483179000054 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 483179000055 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 483179000056 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179000057 dimer interface [polypeptide binding]; other site 483179000058 conserved gate region; other site 483179000059 putative PBP binding loops; other site 483179000060 ABC-ATPase subunit interface; other site 483179000061 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 483179000062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179000063 dimer interface [polypeptide binding]; other site 483179000064 conserved gate region; other site 483179000065 putative PBP binding loops; other site 483179000066 ABC-ATPase subunit interface; other site 483179000067 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 483179000068 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 483179000069 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 483179000070 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 483179000071 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 483179000072 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 483179000073 dimerization interface [polypeptide binding]; other site 483179000074 ligand binding site [chemical binding]; other site 483179000075 enoyl-CoA hydratase; Provisional; Region: PRK07468 483179000076 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 483179000077 substrate binding site [chemical binding]; other site 483179000078 oxyanion hole (OAH) forming residues; other site 483179000079 trimer interface [polypeptide binding]; other site 483179000080 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 483179000081 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 483179000082 ATP-grasp domain; Region: ATP-grasp_4; cl17255 483179000083 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 483179000084 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 483179000085 carboxyltransferase (CT) interaction site; other site 483179000086 biotinylation site [posttranslational modification]; other site 483179000087 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 483179000088 isovaleryl-CoA dehydrogenase; Region: PLN02519 483179000089 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 483179000090 substrate binding site [chemical binding]; other site 483179000091 FAD binding site [chemical binding]; other site 483179000092 catalytic base [active] 483179000093 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 483179000094 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 483179000095 acyl-activating enzyme (AAE) consensus motif; other site 483179000096 putative AMP binding site [chemical binding]; other site 483179000097 putative active site [active] 483179000098 putative CoA binding site [chemical binding]; other site 483179000099 CHRD domain; Region: CHRD; pfam07452 483179000100 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 483179000101 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4530 483179000102 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 483179000103 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 483179000104 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 483179000105 hinge; other site 483179000106 active site 483179000107 cytidylate kinase; Provisional; Region: cmk; PRK00023 483179000108 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 483179000109 CMP-binding site; other site 483179000110 The sites determining sugar specificity; other site 483179000111 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 483179000112 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 483179000113 RNA binding site [nucleotide binding]; other site 483179000114 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 483179000115 RNA binding site [nucleotide binding]; other site 483179000116 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 483179000117 RNA binding site [nucleotide binding]; other site 483179000118 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 483179000119 RNA binding site [nucleotide binding]; other site 483179000120 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 483179000121 RNA binding site [nucleotide binding]; other site 483179000122 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 483179000123 RNA binding site [nucleotide binding]; other site 483179000124 Predicted membrane protein [Function unknown]; Region: COG2855 483179000125 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 483179000126 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 483179000127 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 483179000128 putative dimerization interface [polypeptide binding]; other site 483179000129 lytic murein transglycosylase; Region: MltB_2; TIGR02283 483179000130 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 483179000131 N-acetyl-D-glucosamine binding site [chemical binding]; other site 483179000132 recombination protein RecR; Reviewed; Region: recR; PRK00076 483179000133 RecR protein; Region: RecR; pfam02132 483179000134 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 483179000135 putative active site [active] 483179000136 putative metal-binding site [ion binding]; other site 483179000137 tetramer interface [polypeptide binding]; other site 483179000138 hypothetical protein; Validated; Region: PRK00153 483179000139 DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111 483179000140 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483179000141 Walker A motif; other site 483179000142 ATP binding site [chemical binding]; other site 483179000143 Walker B motif; other site 483179000144 arginine finger; other site 483179000145 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 483179000146 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 483179000147 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 483179000148 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 483179000149 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 483179000150 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 483179000151 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 483179000152 putative NADH binding site [chemical binding]; other site 483179000153 putative active site [active] 483179000154 nudix motif; other site 483179000155 putative metal binding site [ion binding]; other site 483179000156 prephenate dehydratase; Provisional; Region: PRK11899 483179000157 Prephenate dehydratase; Region: PDT; pfam00800 483179000158 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 483179000159 putative L-Phe binding site [chemical binding]; other site 483179000160 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 483179000161 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 483179000162 Ligand binding site; other site 483179000163 oligomer interface; other site 483179000164 Cytochrome c2 [Energy production and conversion]; Region: COG3474 483179000165 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 483179000166 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 483179000167 putative MPT binding site; other site 483179000168 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 483179000169 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 483179000170 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 483179000171 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 483179000172 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 483179000173 D-pathway; other site 483179000174 Putative ubiquinol binding site [chemical binding]; other site 483179000175 Low-spin heme (heme b) binding site [chemical binding]; other site 483179000176 Putative water exit pathway; other site 483179000177 Binuclear center (heme o3/CuB) [ion binding]; other site 483179000178 K-pathway; other site 483179000179 Putative proton exit pathway; other site 483179000180 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 483179000181 Subunit I/III interface [polypeptide binding]; other site 483179000182 Subunit III/IV interface [polypeptide binding]; other site 483179000183 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 483179000184 Bacterial SH3 domain; Region: SH3_3; pfam08239 483179000185 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 483179000186 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 483179000187 Surface antigen; Region: Bac_surface_Ag; pfam01103 483179000188 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 483179000189 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 483179000190 Family of unknown function (DUF490); Region: DUF490; pfam04357 483179000191 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 483179000192 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 483179000193 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 483179000194 Copper(I)-binding protein [Inorganic ion transport and metabolism]; Region: COG2847 483179000195 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 483179000196 dimer interface [polypeptide binding]; other site 483179000197 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 483179000198 active site 483179000199 metal binding site [ion binding]; metal-binding site 483179000200 glutathione binding site [chemical binding]; other site 483179000201 Domain of unknown function DUF59; Region: DUF59; pfam01883 483179000202 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 483179000203 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 483179000204 Walker A motif; other site 483179000205 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 483179000206 phosphoglucomutase; Region: PLN02307 483179000207 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 483179000208 substrate binding site [chemical binding]; other site 483179000209 dimer interface [polypeptide binding]; other site 483179000210 active site 483179000211 metal binding site [ion binding]; metal-binding site 483179000212 Transcriptional regulator [Transcription]; Region: LysR; COG0583 483179000213 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 483179000214 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 483179000215 putative effector binding pocket; other site 483179000216 putative dimerization interface [polypeptide binding]; other site 483179000217 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 483179000218 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 483179000219 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 483179000220 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 483179000221 active site 483179000222 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 483179000223 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 483179000224 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 483179000225 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 483179000226 N-acetyl-D-glucosamine binding site [chemical binding]; other site 483179000227 catalytic residue [active] 483179000228 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 483179000229 DNA Polymerase Y-family; Region: PolY_like; cd03468 483179000230 active site 483179000231 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 483179000232 DNA binding site [nucleotide binding] 483179000233 Uncharacterized conserved protein [Function unknown]; Region: COG4544 483179000234 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 483179000235 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 483179000236 trimer interface [polypeptide binding]; other site 483179000237 Haemagglutinin; Region: HIM; pfam05662 483179000238 YadA-like C-terminal region; Region: YadA; pfam03895 483179000239 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 483179000240 argininosuccinate synthase; Provisional; Region: PRK13820 483179000241 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 483179000242 ANP binding site [chemical binding]; other site 483179000243 Substrate Binding Site II [chemical binding]; other site 483179000244 Substrate Binding Site I [chemical binding]; other site 483179000245 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 483179000246 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 483179000247 FeS/SAM binding site; other site 483179000248 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 483179000249 Uncharacterized conserved protein [Function unknown]; Region: COG3339 483179000250 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 483179000251 aromatic arch; other site 483179000252 DCoH dimer interaction site [polypeptide binding]; other site 483179000253 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 483179000254 DCoH tetramer interaction site [polypeptide binding]; other site 483179000255 substrate binding site [chemical binding]; other site 483179000256 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 483179000257 Low molecular weight phosphatase family; Region: LMWPc; cd00115 483179000258 active site 483179000259 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 483179000260 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 483179000261 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 483179000262 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 483179000263 active site 483179000264 catalytic triad [active] 483179000265 oxyanion hole [active] 483179000266 switch loop; other site 483179000267 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 483179000268 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 483179000269 Walker A/P-loop; other site 483179000270 ATP binding site [chemical binding]; other site 483179000271 Q-loop/lid; other site 483179000272 ABC transporter signature motif; other site 483179000273 Walker B; other site 483179000274 D-loop; other site 483179000275 H-loop/switch region; other site 483179000276 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 483179000277 ybhL leader; BCAN_A0089 483179000278 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 483179000279 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 483179000280 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 483179000281 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 483179000282 Coenzyme A binding pocket [chemical binding]; other site 483179000283 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 483179000284 Uncharacterized secreted protein [Function unknown]; Region: COG5429 483179000285 aconitate hydratase; Validated; Region: PRK09277 483179000286 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 483179000287 substrate binding site [chemical binding]; other site 483179000288 ligand binding site [chemical binding]; other site 483179000289 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 483179000290 substrate binding site [chemical binding]; other site 483179000291 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 483179000292 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 483179000293 Walker A/P-loop; other site 483179000294 ATP binding site [chemical binding]; other site 483179000295 Q-loop/lid; other site 483179000296 ABC transporter signature motif; other site 483179000297 Walker B; other site 483179000298 D-loop; other site 483179000299 H-loop/switch region; other site 483179000300 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmB; COG2386 483179000301 heme exporter protein CcmC; Region: ccmC; TIGR01191 483179000302 heme exporter protein CcmD; Region: cytochro_ccmD; TIGR03141 483179000303 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 483179000304 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 483179000305 catalytic residues [active] 483179000306 central insert; other site 483179000307 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 483179000308 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 483179000309 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 483179000310 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483179000311 active site 483179000312 phosphorylation site [posttranslational modification] 483179000313 intermolecular recognition site; other site 483179000314 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 483179000315 AsnC family; Region: AsnC_trans_reg; pfam01037 483179000316 Domain of Unknown Function (DUF930); Region: DUF930; pfam06059 483179000317 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604 483179000318 Uncharacterized conserved protein [Function unknown]; Region: COG1434 483179000319 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 483179000320 putative active site [active] 483179000321 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 483179000322 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 483179000323 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 483179000324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179000325 dimer interface [polypeptide binding]; other site 483179000326 conserved gate region; other site 483179000327 putative PBP binding loops; other site 483179000328 ABC-ATPase subunit interface; other site 483179000329 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179000330 dimer interface [polypeptide binding]; other site 483179000331 conserved gate region; other site 483179000332 putative PBP binding loops; other site 483179000333 ABC-ATPase subunit interface; other site 483179000334 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 483179000335 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 483179000336 Walker A/P-loop; other site 483179000337 ATP binding site [chemical binding]; other site 483179000338 Q-loop/lid; other site 483179000339 ABC transporter signature motif; other site 483179000340 Walker B; other site 483179000341 D-loop; other site 483179000342 H-loop/switch region; other site 483179000343 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 483179000344 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 483179000345 Putative glucoamylase; Region: Glycoamylase; pfam10091 483179000346 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 483179000347 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 483179000348 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 483179000349 Protein of unknown function, DUF608; Region: DUF608; pfam04685 483179000350 Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488 483179000351 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 483179000352 active site 483179000353 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 483179000354 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483179000355 S-adenosylmethionine binding site [chemical binding]; other site 483179000356 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 483179000357 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 483179000358 putative substrate binding site [chemical binding]; other site 483179000359 putative ATP binding site [chemical binding]; other site 483179000360 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 483179000361 classical (c) SDRs; Region: SDR_c; cd05233 483179000362 NAD(P) binding site [chemical binding]; other site 483179000363 active site 483179000364 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 483179000365 Transglycosylase; Region: Transgly; pfam00912 483179000366 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 483179000367 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 483179000368 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 483179000369 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 483179000370 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 483179000371 catalytic site [active] 483179000372 putative active site [active] 483179000373 putative substrate binding site [chemical binding]; other site 483179000374 hypothetical protein; Validated; Region: PRK09104 483179000375 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 483179000376 metal binding site [ion binding]; metal-binding site 483179000377 putative dimer interface [polypeptide binding]; other site 483179000378 DNA polymerase I; Region: pola; TIGR00593 483179000379 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 483179000380 active site 483179000381 metal binding site 1 [ion binding]; metal-binding site 483179000382 putative 5' ssDNA interaction site; other site 483179000383 metal binding site 3; metal-binding site 483179000384 metal binding site 2 [ion binding]; metal-binding site 483179000385 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 483179000386 putative DNA binding site [nucleotide binding]; other site 483179000387 putative metal binding site [ion binding]; other site 483179000388 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 483179000389 active site 483179000390 catalytic site [active] 483179000391 substrate binding site [chemical binding]; other site 483179000392 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 483179000393 active site 483179000394 DNA binding site [nucleotide binding] 483179000395 catalytic site [active] 483179000396 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 483179000397 DEAD-like helicases superfamily; Region: DEXDc; smart00487 483179000398 ATP binding site [chemical binding]; other site 483179000399 Mg++ binding site [ion binding]; other site 483179000400 motif III; other site 483179000401 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 483179000402 nucleotide binding region [chemical binding]; other site 483179000403 ATP-binding site [chemical binding]; other site 483179000404 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 483179000405 RNA binding site [nucleotide binding]; other site 483179000406 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 483179000407 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483179000408 Mg2+ binding site [ion binding]; other site 483179000409 G-X-G motif; other site 483179000410 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 483179000411 anchoring element; other site 483179000412 dimer interface [polypeptide binding]; other site 483179000413 ATP binding site [chemical binding]; other site 483179000414 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 483179000415 active site 483179000416 metal binding site [ion binding]; metal-binding site 483179000417 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 483179000418 S-formylglutathione hydrolase; Region: PLN02442 483179000419 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 483179000420 Predicted membrane protein [Function unknown]; Region: COG4291 483179000421 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 483179000422 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 483179000423 Coenzyme A binding pocket [chemical binding]; other site 483179000424 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 483179000425 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 483179000426 substrate binding site [chemical binding]; other site 483179000427 catalytic Zn binding site [ion binding]; other site 483179000428 NAD binding site [chemical binding]; other site 483179000429 structural Zn binding site [ion binding]; other site 483179000430 dimer interface [polypeptide binding]; other site 483179000431 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 483179000432 putative metal binding site [ion binding]; other site 483179000433 putative homodimer interface [polypeptide binding]; other site 483179000434 putative homotetramer interface [polypeptide binding]; other site 483179000435 putative homodimer-homodimer interface [polypeptide binding]; other site 483179000436 putative allosteric switch controlling residues; other site 483179000437 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483179000438 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483179000439 ATP binding site [chemical binding]; other site 483179000440 Mg2+ binding site [ion binding]; other site 483179000441 G-X-G motif; other site 483179000442 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 483179000443 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 483179000444 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 483179000445 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 483179000446 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 483179000447 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 483179000448 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483179000449 active site 483179000450 phosphorylation site [posttranslational modification] 483179000451 intermolecular recognition site; other site 483179000452 dimerization interface [polypeptide binding]; other site 483179000453 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 483179000454 Protein of unknown function (DUF1052); Region: DUF1052; cl02197 483179000455 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 483179000456 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 483179000457 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 483179000458 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 483179000459 Universal stress protein family; Region: Usp; pfam00582 483179000460 Ligand Binding Site [chemical binding]; other site 483179000461 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 483179000462 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 483179000463 active site 483179000464 HIGH motif; other site 483179000465 dimer interface [polypeptide binding]; other site 483179000466 KMSKS motif; other site 483179000467 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 483179000468 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 483179000469 PII uridylyl-transferase; Provisional; Region: PRK05092 483179000470 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 483179000471 metal binding triad; other site 483179000472 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 483179000473 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 483179000474 Zn2+ binding site [ion binding]; other site 483179000475 Mg2+ binding site [ion binding]; other site 483179000476 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 483179000477 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 483179000478 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 483179000479 MutS domain I; Region: MutS_I; pfam01624 483179000480 MutS domain II; Region: MutS_II; pfam05188 483179000481 MutS domain III; Region: MutS_III; pfam05192 483179000482 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 483179000483 Walker A/P-loop; other site 483179000484 ATP binding site [chemical binding]; other site 483179000485 Q-loop/lid; other site 483179000486 ABC transporter signature motif; other site 483179000487 Walker B; other site 483179000488 D-loop; other site 483179000489 H-loop/switch region; other site 483179000490 Putative hemolysin [General function prediction only]; Region: COG3176 483179000491 lipoprotein signal peptidase; Provisional; Region: PRK14795 483179000492 lipoprotein signal peptidase; Provisional; Region: PRK14787 483179000493 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 483179000494 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 483179000495 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 483179000496 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 483179000497 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483179000498 S-adenosylmethionine binding site [chemical binding]; other site 483179000499 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 483179000500 IHF dimer interface [polypeptide binding]; other site 483179000501 IHF - DNA interface [nucleotide binding]; other site 483179000502 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 483179000503 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 483179000504 tandem repeat interface [polypeptide binding]; other site 483179000505 oligomer interface [polypeptide binding]; other site 483179000506 active site residues [active] 483179000507 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 483179000508 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 483179000509 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 483179000510 OstA-like protein; Region: OstA; pfam03968 483179000511 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 483179000512 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 483179000513 Walker A/P-loop; other site 483179000514 ATP binding site [chemical binding]; other site 483179000515 Q-loop/lid; other site 483179000516 ABC transporter signature motif; other site 483179000517 Walker B; other site 483179000518 D-loop; other site 483179000519 H-loop/switch region; other site 483179000520 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 483179000521 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 483179000522 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 483179000523 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 483179000524 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 483179000525 30S subunit binding site; other site 483179000526 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 483179000527 active site 483179000528 phosphorylation site [posttranslational modification] 483179000529 Uncharacterized small protein [Function unknown]; Region: COG5568 483179000530 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 483179000531 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 483179000532 putative dimer interface [polypeptide binding]; other site 483179000533 Integral membrane protein [Function unknown]; Region: COG5488 483179000534 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 483179000535 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 483179000536 minor groove reading motif; other site 483179000537 helix-hairpin-helix signature motif; other site 483179000538 substrate binding pocket [chemical binding]; other site 483179000539 active site 483179000540 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 483179000541 CysZ-like protein; Reviewed; Region: PRK12768 483179000542 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 483179000543 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 483179000544 substrate binding site [chemical binding]; other site 483179000545 ATP binding site [chemical binding]; other site 483179000546 Predicted membrane protein [Function unknown]; Region: COG2860 483179000547 UPF0126 domain; Region: UPF0126; pfam03458 483179000548 UPF0126 domain; Region: UPF0126; pfam03458 483179000549 heat shock protein GrpE; Provisional; Region: PRK14141 483179000550 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 483179000551 dimer interface [polypeptide binding]; other site 483179000552 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 483179000553 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 483179000554 ribonuclease PH; Reviewed; Region: rph; PRK00173 483179000555 Ribonuclease PH; Region: RNase_PH_bact; cd11362 483179000556 hexamer interface [polypeptide binding]; other site 483179000557 active site 483179000558 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 483179000559 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 483179000560 putative metal binding site [ion binding]; other site 483179000561 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 483179000562 active site 483179000563 dimerization interface [polypeptide binding]; other site 483179000564 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 483179000565 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 483179000566 FeS/SAM binding site; other site 483179000567 HemN C-terminal domain; Region: HemN_C; pfam06969 483179000568 Predicted methyltransferases [General function prediction only]; Region: COG0313 483179000569 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 483179000570 putative SAM binding site [chemical binding]; other site 483179000571 putative homodimer interface [polypeptide binding]; other site 483179000572 hypothetical protein; Reviewed; Region: PRK12497 483179000573 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 483179000574 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 483179000575 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 483179000576 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 483179000577 active site 483179000578 SAM binding site [chemical binding]; other site 483179000579 homodimer interface [polypeptide binding]; other site 483179000580 Protein of unknown function (DUF2849); Region: DUF2849; pfam11011 483179000581 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 483179000582 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 483179000583 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 483179000584 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 483179000585 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 483179000586 Active Sites [active] 483179000587 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3749 483179000588 Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876 483179000589 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 483179000590 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 483179000591 active site 483179000592 DNA binding site [nucleotide binding] 483179000593 BA14K-like protein; Region: BA14K; pfam07886 483179000594 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 483179000595 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 483179000596 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 483179000597 substrate binding pocket [chemical binding]; other site 483179000598 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 483179000599 B12 binding site [chemical binding]; other site 483179000600 cobalt ligand [ion binding]; other site 483179000601 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 483179000602 Dehydratase family; Region: ILVD_EDD; cl00340 483179000603 Autoinducer binding domain; Region: Autoind_bind; pfam03472 483179000604 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 483179000605 DNA binding residues [nucleotide binding] 483179000606 aminotransferase; Provisional; Region: PRK06105 483179000607 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 483179000608 inhibitor-cofactor binding pocket; inhibition site 483179000609 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483179000610 catalytic residue [active] 483179000611 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 483179000612 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 483179000613 Active Sites [active] 483179000614 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 483179000615 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 483179000616 CysD dimerization site [polypeptide binding]; other site 483179000617 G1 box; other site 483179000618 putative GEF interaction site [polypeptide binding]; other site 483179000619 GTP/Mg2+ binding site [chemical binding]; other site 483179000620 Switch I region; other site 483179000621 G2 box; other site 483179000622 G3 box; other site 483179000623 Switch II region; other site 483179000624 G4 box; other site 483179000625 G5 box; other site 483179000626 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 483179000627 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 483179000628 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 483179000629 ligand-binding site [chemical binding]; other site 483179000630 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 483179000631 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 483179000632 active site 483179000633 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 483179000634 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 483179000635 ligand binding site [chemical binding]; other site 483179000636 flexible hinge region; other site 483179000637 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 483179000638 putative switch regulator; other site 483179000639 non-specific DNA interactions [nucleotide binding]; other site 483179000640 DNA binding site [nucleotide binding] 483179000641 sequence specific DNA binding site [nucleotide binding]; other site 483179000642 putative cAMP binding site [chemical binding]; other site 483179000643 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 483179000644 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 483179000645 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 483179000646 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 483179000647 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 483179000648 GAF domain; Region: GAF; pfam01590 483179000649 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 483179000650 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 483179000651 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 483179000652 NAD(P) binding site [chemical binding]; other site 483179000653 catalytic residues [active] 483179000654 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 483179000655 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 483179000656 NAD binding site [chemical binding]; other site 483179000657 substrate binding site [chemical binding]; other site 483179000658 catalytic Zn binding site [ion binding]; other site 483179000659 tetramer interface [polypeptide binding]; other site 483179000660 structural Zn binding site [ion binding]; other site 483179000661 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3564 483179000662 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 483179000663 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 483179000664 NAD(P) binding site [chemical binding]; other site 483179000665 catalytic residues [active] 483179000666 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 483179000667 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179000668 dimer interface [polypeptide binding]; other site 483179000669 conserved gate region; other site 483179000670 putative PBP binding loops; other site 483179000671 ABC-ATPase subunit interface; other site 483179000672 Putative transcription activator [Transcription]; Region: TenA; COG0819 483179000673 NMT1/THI5 like; Region: NMT1; pfam09084 483179000674 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 483179000675 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 483179000676 active site 483179000677 thiamine phosphate binding site [chemical binding]; other site 483179000678 pyrophosphate binding site [ion binding]; other site 483179000679 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 483179000680 ThiS interaction site; other site 483179000681 putative active site [active] 483179000682 tetramer interface [polypeptide binding]; other site 483179000683 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 483179000684 thiS-thiF/thiG interaction site; other site 483179000685 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 483179000686 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 483179000687 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 483179000688 dimer interface [polypeptide binding]; other site 483179000689 substrate binding site [chemical binding]; other site 483179000690 ATP binding site [chemical binding]; other site 483179000691 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483179000692 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 483179000693 putative active site [active] 483179000694 heme pocket [chemical binding]; other site 483179000695 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483179000696 putative active site [active] 483179000697 heme pocket [chemical binding]; other site 483179000698 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 483179000699 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 483179000700 metal binding site [ion binding]; metal-binding site 483179000701 active site 483179000702 I-site; other site 483179000703 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 483179000704 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 483179000705 metal-binding site [ion binding] 483179000706 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 483179000707 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 483179000708 metal-binding site [ion binding] 483179000709 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 483179000710 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 483179000711 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 483179000712 DNA binding residues [nucleotide binding] 483179000713 dimer interface [polypeptide binding]; other site 483179000714 copper binding site [ion binding]; other site 483179000715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179000716 dimer interface [polypeptide binding]; other site 483179000717 conserved gate region; other site 483179000718 putative PBP binding loops; other site 483179000719 ABC-ATPase subunit interface; other site 483179000720 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 483179000721 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 483179000722 Walker A/P-loop; other site 483179000723 ATP binding site [chemical binding]; other site 483179000724 Q-loop/lid; other site 483179000725 ABC transporter signature motif; other site 483179000726 Walker B; other site 483179000727 D-loop; other site 483179000728 H-loop/switch region; other site 483179000729 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 483179000730 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179000731 dimer interface [polypeptide binding]; other site 483179000732 conserved gate region; other site 483179000733 ABC-ATPase subunit interface; other site 483179000734 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 483179000735 Uncharacterized conserved protein [Function unknown]; Region: COG5514 483179000736 heme-binding site [chemical binding]; other site 483179000737 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 483179000738 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 483179000739 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 483179000740 NAD(P) binding site [chemical binding]; other site 483179000741 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 483179000742 hydroxyglutarate oxidase; Provisional; Region: PRK11728 483179000743 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 483179000744 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 483179000745 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 483179000746 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 483179000747 Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583 483179000748 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 483179000749 Amidohydrolase; Region: Amidohydro_2; pfam04909 483179000750 active site 483179000751 Transcriptional regulator [Transcription]; Region: IclR; COG1414 483179000752 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 483179000753 putative DNA binding site [nucleotide binding]; other site 483179000754 putative Zn2+ binding site [ion binding]; other site 483179000755 Bacterial transcriptional regulator; Region: IclR; pfam01614 483179000756 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 483179000757 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 483179000758 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179000759 dimer interface [polypeptide binding]; other site 483179000760 conserved gate region; other site 483179000761 putative PBP binding loops; other site 483179000762 ABC-ATPase subunit interface; other site 483179000763 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 483179000764 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179000765 dimer interface [polypeptide binding]; other site 483179000766 conserved gate region; other site 483179000767 putative PBP binding loops; other site 483179000768 ABC-ATPase subunit interface; other site 483179000769 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 483179000770 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 483179000771 Walker A/P-loop; other site 483179000772 ATP binding site [chemical binding]; other site 483179000773 Q-loop/lid; other site 483179000774 ABC transporter signature motif; other site 483179000775 Walker B; other site 483179000776 D-loop; other site 483179000777 H-loop/switch region; other site 483179000778 TOBE domain; Region: TOBE_2; pfam08402 483179000779 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 483179000780 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 483179000781 active site pocket [active] 483179000782 Uncharacterized conserved protein [Function unknown]; Region: COG3254 483179000783 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 483179000784 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 483179000785 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 483179000786 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 483179000787 NAD binding site [chemical binding]; other site 483179000788 homotetramer interface [polypeptide binding]; other site 483179000789 homodimer interface [polypeptide binding]; other site 483179000790 active site 483179000791 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 483179000792 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 483179000793 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 483179000794 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 483179000795 putative active site pocket [active] 483179000796 metal binding site [ion binding]; metal-binding site 483179000797 zinc-binding protein; Provisional; Region: PRK01343 483179000798 Maf-like protein; Region: Maf; pfam02545 483179000799 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 483179000800 active site 483179000801 dimer interface [polypeptide binding]; other site 483179000802 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 483179000803 rRNA binding site [nucleotide binding]; other site 483179000804 predicted 30S ribosome binding site; other site 483179000805 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 483179000806 Low molecular weight phosphatase family; Region: LMWPc; cd00115 483179000807 active site 483179000808 hypothetical protein; Provisional; Region: PRK02853 483179000809 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 483179000810 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 483179000811 NAD binding site [chemical binding]; other site 483179000812 dimerization interface [polypeptide binding]; other site 483179000813 product binding site; other site 483179000814 substrate binding site [chemical binding]; other site 483179000815 zinc binding site [ion binding]; other site 483179000816 catalytic residues [active] 483179000817 Protein of unknown function (DUF2948); Region: DUF2948; pfam11164 483179000818 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 483179000819 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 483179000820 hinge; other site 483179000821 active site 483179000822 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 483179000823 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 483179000824 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 483179000825 active site 483179000826 DNA binding site [nucleotide binding] 483179000827 Int/Topo IB signature motif; other site 483179000828 Prophage antirepressor [Transcription]; Region: COG3617 483179000829 BRO family, N-terminal domain; Region: Bro-N; smart01040 483179000830 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 483179000831 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 483179000832 catalytic residues [active] 483179000833 catalytic nucleophile [active] 483179000834 Presynaptic Site I dimer interface [polypeptide binding]; other site 483179000835 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 483179000836 Synaptic Flat tetramer interface [polypeptide binding]; other site 483179000837 Synaptic Site I dimer interface [polypeptide binding]; other site 483179000838 DNA binding site [nucleotide binding] 483179000839 BRO family, N-terminal domain; Region: Bro-N; cl10591 483179000840 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 483179000841 non-specific DNA binding site [nucleotide binding]; other site 483179000842 salt bridge; other site 483179000843 sequence-specific DNA binding site [nucleotide binding]; other site 483179000844 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 483179000845 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 483179000846 alpha-gamma subunit interface [polypeptide binding]; other site 483179000847 beta-gamma subunit interface [polypeptide binding]; other site 483179000848 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 483179000849 gamma-beta subunit interface [polypeptide binding]; other site 483179000850 alpha-beta subunit interface [polypeptide binding]; other site 483179000851 urease subunit alpha; Reviewed; Region: ureC; PRK13207 483179000852 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 483179000853 subunit interactions [polypeptide binding]; other site 483179000854 active site 483179000855 flap region; other site 483179000856 Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371 483179000857 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 483179000858 dimer interface [polypeptide binding]; other site 483179000859 catalytic residues [active] 483179000860 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 483179000861 UreF; Region: UreF; pfam01730 483179000862 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 483179000863 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483179000864 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483179000865 ATP binding site [chemical binding]; other site 483179000866 Mg2+ binding site [ion binding]; other site 483179000867 G-X-G motif; other site 483179000868 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 483179000869 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 483179000870 HlyD family secretion protein; Region: HlyD_3; pfam13437 483179000871 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 483179000872 phenylhydantoinase; Validated; Region: PRK08323 483179000873 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 483179000874 tetramer interface [polypeptide binding]; other site 483179000875 active site 483179000876 allantoate amidohydrolase; Reviewed; Region: PRK12893 483179000877 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 483179000878 active site 483179000879 metal binding site [ion binding]; metal-binding site 483179000880 dimer interface [polypeptide binding]; other site 483179000881 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 483179000882 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 483179000883 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 483179000884 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 483179000885 nudix motif; other site 483179000886 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 483179000887 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 483179000888 homodimer interface [polypeptide binding]; other site 483179000889 active site 483179000890 FMN binding site [chemical binding]; other site 483179000891 substrate binding site [chemical binding]; other site 483179000892 4Fe-4S binding domain; Region: Fer4; cl02805 483179000893 4Fe-4S binding domain; Region: Fer4; pfam00037 483179000894 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 483179000895 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 483179000896 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 483179000897 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 483179000898 putative hydrophobic ligand binding site [chemical binding]; other site 483179000899 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 483179000900 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 483179000901 active site 483179000902 dimer interface [polypeptide binding]; other site 483179000903 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 483179000904 dimer interface [polypeptide binding]; other site 483179000905 active site 483179000906 Predicted deacylase [General function prediction only]; Region: COG3608 483179000907 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 483179000908 active site 483179000909 Zn binding site [ion binding]; other site 483179000910 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 483179000911 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 483179000912 motif II; other site 483179000913 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 483179000914 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 483179000915 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 483179000916 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 483179000917 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 483179000918 acyl-activating enzyme (AAE) consensus motif; other site 483179000919 putative AMP binding site [chemical binding]; other site 483179000920 putative active site [active] 483179000921 putative CoA binding site [chemical binding]; other site 483179000922 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 483179000923 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 483179000924 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 483179000925 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 483179000926 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 483179000927 HlyD family secretion protein; Region: HlyD_3; pfam13437 483179000928 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 483179000929 Protein export membrane protein; Region: SecD_SecF; cl14618 483179000930 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 483179000931 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 483179000932 substrate binding pocket [chemical binding]; other site 483179000933 membrane-bound complex binding site; other site 483179000934 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 483179000935 CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427 483179000936 DXD motif; other site 483179000937 Uncharacterized conserved protein [Function unknown]; Region: COG2326 483179000938 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 483179000939 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483179000940 dimer interface [polypeptide binding]; other site 483179000941 phosphorylation site [posttranslational modification] 483179000942 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483179000943 ATP binding site [chemical binding]; other site 483179000944 Mg2+ binding site [ion binding]; other site 483179000945 G-X-G motif; other site 483179000946 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5352 483179000947 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 483179000948 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 483179000949 inhibitor-cofactor binding pocket; inhibition site 483179000950 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483179000951 catalytic residue [active] 483179000952 ornithine carbamoyltransferase; Provisional; Region: PRK00779 483179000953 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 483179000954 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 483179000955 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 483179000956 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 483179000957 dimerization interface [polypeptide binding]; other site 483179000958 domain crossover interface; other site 483179000959 redox-dependent activation switch; other site 483179000960 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 483179000961 O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504 483179000962 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 483179000963 homodimer interface [polypeptide binding]; other site 483179000964 substrate-cofactor binding pocket; other site 483179000965 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483179000966 catalytic residue [active] 483179000967 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 483179000968 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 483179000969 trimer interface [polypeptide binding]; other site 483179000970 active site 483179000971 Deoxycytidine deaminase [Nucleotide transport and metabolism]; Region: Dcd; COG0717 483179000972 trimer interface [polypeptide binding]; other site 483179000973 active site 483179000974 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 483179000975 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 483179000976 conserved cys residue [active] 483179000977 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 483179000978 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 483179000979 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 483179000980 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 483179000981 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 483179000982 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 483179000983 quinone interaction residues [chemical binding]; other site 483179000984 active site 483179000985 catalytic residues [active] 483179000986 FMN binding site [chemical binding]; other site 483179000987 substrate binding site [chemical binding]; other site 483179000988 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 483179000989 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 483179000990 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 483179000991 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 483179000992 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483179000993 active site 483179000994 phosphorylation site [posttranslational modification] 483179000995 intermolecular recognition site; other site 483179000996 dimerization interface [polypeptide binding]; other site 483179000997 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 483179000998 DNA binding residues [nucleotide binding] 483179000999 dimerization interface [polypeptide binding]; other site 483179001000 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 483179001001 Na binding site [ion binding]; other site 483179001002 PAS fold; Region: PAS_7; pfam12860 483179001003 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483179001004 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483179001005 dimer interface [polypeptide binding]; other site 483179001006 phosphorylation site [posttranslational modification] 483179001007 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483179001008 ATP binding site [chemical binding]; other site 483179001009 Mg2+ binding site [ion binding]; other site 483179001010 G-X-G motif; other site 483179001011 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 483179001012 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483179001013 active site 483179001014 phosphorylation site [posttranslational modification] 483179001015 intermolecular recognition site; other site 483179001016 dimerization interface [polypeptide binding]; other site 483179001017 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 483179001018 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 483179001019 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 483179001020 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 483179001021 substrate-cofactor binding pocket; other site 483179001022 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483179001023 catalytic residue [active] 483179001024 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 483179001025 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 483179001026 putative active site [active] 483179001027 putative metal binding site [ion binding]; other site 483179001028 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 483179001029 Glycosyltransferase family 29 (sialyltransferase); Region: Glyco_transf_29; pfam00777 483179001030 Transcriptional regulator [Transcription]; Region: LysR; COG0583 483179001031 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 483179001032 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 483179001033 putative dimerization interface [polypeptide binding]; other site 483179001034 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 483179001035 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 483179001036 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 483179001037 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 483179001038 pantoate--beta-alanine ligase; Region: panC; TIGR00018 483179001039 Pantoate-beta-alanine ligase; Region: PanC; cd00560 483179001040 active site 483179001041 ATP-binding site [chemical binding]; other site 483179001042 pantoate-binding site; other site 483179001043 HXXH motif; other site 483179001044 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 483179001045 active site 483179001046 oligomerization interface [polypeptide binding]; other site 483179001047 metal binding site [ion binding]; metal-binding site 483179001048 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 483179001049 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 483179001050 FAD binding pocket [chemical binding]; other site 483179001051 FAD binding motif [chemical binding]; other site 483179001052 phosphate binding motif [ion binding]; other site 483179001053 beta-alpha-beta structure motif; other site 483179001054 NAD binding pocket [chemical binding]; other site 483179001055 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 483179001056 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 483179001057 dimer interface [polypeptide binding]; other site 483179001058 active site 483179001059 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 483179001060 catalytic residues [active] 483179001061 substrate binding site [chemical binding]; other site 483179001062 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 483179001063 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 483179001064 NAD(P) binding pocket [chemical binding]; other site 483179001065 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 483179001066 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 483179001067 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 483179001068 multidrug efflux protein; Reviewed; Region: PRK01766 483179001069 cation binding site [ion binding]; other site 483179001070 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 483179001071 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 483179001072 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483179001073 active site 483179001074 phosphorylation site [posttranslational modification] 483179001075 intermolecular recognition site; other site 483179001076 dimerization interface [polypeptide binding]; other site 483179001077 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 483179001078 DNA binding residues [nucleotide binding] 483179001079 dimerization interface [polypeptide binding]; other site 483179001080 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 483179001081 DctM-like transporters; Region: DctM; pfam06808 483179001082 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 483179001083 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 483179001084 hypothetical protein; Provisional; Region: PRK11171 483179001085 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 483179001086 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 483179001087 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 483179001088 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 483179001089 active site 483179001090 catalytic site [active] 483179001091 tetramer interface [polypeptide binding]; other site 483179001092 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 483179001093 Transthyretin_like. This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase). TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl17222 483179001094 homotetramer interface [polypeptide binding]; other site 483179001095 active site 483179001096 Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [Nucleotide transport and metabolism]; Region: XdhA; COG4630 483179001097 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 483179001098 catalytic loop [active] 483179001099 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 483179001100 iron binding site [ion binding]; other site 483179001101 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 483179001102 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 483179001103 Xanthine dehydrogenase, molybdopterin-binding subunit B [Nucleotide transport and metabolism]; Region: XdhB; COG4631 483179001104 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 483179001105 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 483179001106 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 483179001107 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 483179001108 XdhC Rossmann domain; Region: XdhC_C; pfam13478 483179001109 Transcriptional regulator [Transcription]; Region: LysR; COG0583 483179001110 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 483179001111 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 483179001112 putative effector binding pocket; other site 483179001113 dimerization interface [polypeptide binding]; other site 483179001114 Predicted membrane protein [Function unknown]; Region: COG3748 483179001115 Protein of unknown function (DUF989); Region: DUF989; pfam06181 483179001116 Cytochrome c; Region: Cytochrom_C; pfam00034 483179001117 guanine deaminase; Provisional; Region: PRK09228 483179001118 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 483179001119 active site 483179001120 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 483179001121 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 483179001122 MOFRL family; Region: MOFRL; pfam05161 483179001123 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 483179001124 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 483179001125 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 483179001126 metal-binding site [ion binding] 483179001127 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 483179001128 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 483179001129 motif II; other site 483179001130 Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456 483179001131 FixH; Region: FixH; pfam05751 483179001132 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 483179001133 4Fe-4S binding domain; Region: Fer4_5; pfam12801 483179001134 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 483179001135 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 483179001136 Cytochrome c; Region: Cytochrom_C; pfam00034 483179001137 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 483179001138 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 483179001139 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 483179001140 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 483179001141 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 483179001142 Low-spin heme binding site [chemical binding]; other site 483179001143 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 483179001144 Putative water exit pathway; other site 483179001145 Binuclear center (active site) [active] 483179001146 Putative proton exit pathway; other site 483179001147 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 483179001148 metal binding site 2 [ion binding]; metal-binding site 483179001149 putative DNA binding helix; other site 483179001150 metal binding site 1 [ion binding]; metal-binding site 483179001151 dimer interface [polypeptide binding]; other site 483179001152 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 483179001153 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 483179001154 catalytic residues [active] 483179001155 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 483179001156 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 483179001157 NAD(P) binding site [chemical binding]; other site 483179001158 catalytic residues [active] 483179001159 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 483179001160 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 483179001161 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 483179001162 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 483179001163 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 483179001164 DNA binding site [nucleotide binding] 483179001165 active site 483179001166 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 483179001167 ArsC family; Region: ArsC; pfam03960 483179001168 putative catalytic residues [active] 483179001169 Predicted membrane protein [Function unknown]; Region: COG4129 483179001170 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 483179001171 microcin B17 transporter; Reviewed; Region: PRK11098 483179001172 Putative catalytic domain of uncharacterized bacterial hypothetical proteins similar to insect chitin deacetylase-like proteins; Region: CE4_CDA_like_3; cd10976 483179001173 NodB motif; other site 483179001174 putative active site [active] 483179001175 putative catalytic site [active] 483179001176 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 483179001177 GTP-binding protein Der; Reviewed; Region: PRK00093 483179001178 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 483179001179 G1 box; other site 483179001180 GTP/Mg2+ binding site [chemical binding]; other site 483179001181 Switch I region; other site 483179001182 G2 box; other site 483179001183 Switch II region; other site 483179001184 G3 box; other site 483179001185 G4 box; other site 483179001186 G5 box; other site 483179001187 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 483179001188 G1 box; other site 483179001189 GTP/Mg2+ binding site [chemical binding]; other site 483179001190 Switch I region; other site 483179001191 G2 box; other site 483179001192 G3 box; other site 483179001193 Switch II region; other site 483179001194 G4 box; other site 483179001195 G5 box; other site 483179001196 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 483179001197 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 483179001198 nucleotide binding site [chemical binding]; other site 483179001199 putative NEF/HSP70 interaction site [polypeptide binding]; other site 483179001200 SBD interface [polypeptide binding]; other site 483179001201 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 483179001202 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 483179001203 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5336 483179001204 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 483179001205 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 483179001206 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 483179001207 F0F1 ATP synthase subunit B'; Validated; Region: PRK09174 483179001208 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 483179001209 F0F1 ATP synthase subunit B; Validated; Region: PRK09173 483179001210 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 483179001211 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 483179001212 RNA/DNA hybrid binding site [nucleotide binding]; other site 483179001213 active site 483179001214 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 483179001215 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 483179001216 FeS/SAM binding site; other site 483179001217 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 483179001218 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 483179001219 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 483179001220 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 483179001221 tandem repeat interface [polypeptide binding]; other site 483179001222 oligomer interface [polypeptide binding]; other site 483179001223 active site residues [active] 483179001224 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 483179001225 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 483179001226 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483179001227 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 483179001228 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 483179001229 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 483179001230 substrate binding pocket [chemical binding]; other site 483179001231 chain length determination region; other site 483179001232 substrate-Mg2+ binding site; other site 483179001233 catalytic residues [active] 483179001234 aspartate-rich region 1; other site 483179001235 active site lid residues [active] 483179001236 aspartate-rich region 2; other site 483179001237 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483179001238 binding surface 483179001239 TPR motif; other site 483179001240 TPR repeat; Region: TPR_11; pfam13414 483179001241 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483179001242 binding surface 483179001243 TPR repeat; Region: TPR_11; pfam13414 483179001244 TPR motif; other site 483179001245 TPR repeat; Region: TPR_11; pfam13414 483179001246 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 483179001247 dimer interface [polypeptide binding]; other site 483179001248 motif 1; other site 483179001249 active site 483179001250 motif 2; other site 483179001251 motif 3; other site 483179001252 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 483179001253 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 483179001254 DALR anticodon binding domain; Region: DALR_1; pfam05746 483179001255 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 483179001256 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 483179001257 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 483179001258 FAD binding domain; Region: FAD_binding_4; pfam01565 483179001259 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 483179001260 Predicted transcriptional regulator [Transcription]; Region: COG3905 483179001261 enoyl-CoA hydratase; Provisional; Region: PRK06688 483179001262 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 483179001263 substrate binding site [chemical binding]; other site 483179001264 oxyanion hole (OAH) forming residues; other site 483179001265 trimer interface [polypeptide binding]; other site 483179001266 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 483179001267 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 483179001268 active site 483179001269 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 483179001270 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 483179001271 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 483179001272 metal binding site [ion binding]; metal-binding site 483179001273 active site 483179001274 I-site; other site 483179001275 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 483179001276 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 483179001277 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 483179001278 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 483179001279 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878 483179001280 UbiA prenyltransferase family; Region: UbiA; pfam01040 483179001281 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 483179001282 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 483179001283 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 483179001284 chaperone protein DnaJ; Provisional; Region: PRK14299 483179001285 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 483179001286 HSP70 interaction site [polypeptide binding]; other site 483179001287 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 483179001288 dimer interface [polypeptide binding]; other site 483179001289 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 483179001290 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 483179001291 NAD binding site [chemical binding]; other site 483179001292 homotetramer interface [polypeptide binding]; other site 483179001293 homodimer interface [polypeptide binding]; other site 483179001294 substrate binding site [chemical binding]; other site 483179001295 active site 483179001296 Cold shock proteins [Transcription]; Region: CspC; COG1278 483179001297 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 483179001298 putative acyl-acceptor binding pocket; other site 483179001299 Protein of unknown function (DUF1344); Region: DUF1344; pfam07076 483179001300 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 483179001301 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 483179001302 Tetramer interface [polypeptide binding]; other site 483179001303 active site 483179001304 FMN-binding site [chemical binding]; other site 483179001305 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09314 483179001306 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 483179001307 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 483179001308 dimerization interface [polypeptide binding]; other site 483179001309 active site 483179001310 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 483179001311 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 483179001312 putative active site [active] 483179001313 Zn binding site [ion binding]; other site 483179001314 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 483179001315 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 483179001316 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 483179001317 Predicted membrane protein [Function unknown]; Region: COG2261 483179001318 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3753 483179001319 Pirin-related protein [General function prediction only]; Region: COG1741 483179001320 Pirin; Region: Pirin; pfam02678 483179001321 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 483179001322 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 483179001323 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 483179001324 TPP-binding site; other site 483179001325 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 483179001326 PYR/PP interface [polypeptide binding]; other site 483179001327 dimer interface [polypeptide binding]; other site 483179001328 TPP binding site [chemical binding]; other site 483179001329 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 483179001330 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 483179001331 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 483179001332 RNA binding surface [nucleotide binding]; other site 483179001333 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483179001334 S-adenosylmethionine binding site [chemical binding]; other site 483179001335 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 483179001336 Methyltransferase domain; Region: Methyltransf_26; pfam13659 483179001337 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 483179001338 Predicted periplasmic protein [General function prediction only]; Region: COG3895 483179001339 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 483179001340 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 483179001341 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 483179001342 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 483179001343 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 483179001344 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 483179001345 Walker A/P-loop; other site 483179001346 ATP binding site [chemical binding]; other site 483179001347 Q-loop/lid; other site 483179001348 ABC transporter signature motif; other site 483179001349 Walker B; other site 483179001350 D-loop; other site 483179001351 H-loop/switch region; other site 483179001352 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 483179001353 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 483179001354 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 483179001355 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 483179001356 classical (c) SDRs; Region: SDR_c; cd05233 483179001357 NAD(P) binding site [chemical binding]; other site 483179001358 active site 483179001359 amidophosphoribosyltransferase; Provisional; Region: PRK09123 483179001360 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 483179001361 active site 483179001362 tetramer interface [polypeptide binding]; other site 483179001363 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 483179001364 active site 483179001365 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 483179001366 Colicin V production protein; Region: Colicin_V; pfam02674 483179001367 DNA repair protein RadA; Provisional; Region: PRK11823 483179001368 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 483179001369 Walker A motif/ATP binding site; other site 483179001370 ATP binding site [chemical binding]; other site 483179001371 Walker B motif; other site 483179001372 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 483179001373 replicative DNA helicase; Provisional; Region: PRK09165 483179001374 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 483179001375 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 483179001376 Walker A motif; other site 483179001377 ATP binding site [chemical binding]; other site 483179001378 Walker B motif; other site 483179001379 DNA binding loops [nucleotide binding] 483179001380 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 483179001381 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 483179001382 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 483179001383 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 483179001384 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 483179001385 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 483179001386 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 483179001387 3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936 483179001388 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 483179001389 NAD(P) binding site [chemical binding]; other site 483179001390 homotetramer interface [polypeptide binding]; other site 483179001391 homodimer interface [polypeptide binding]; other site 483179001392 active site 483179001393 acyl carrier protein; Provisional; Region: acpP; PRK00982 483179001394 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 483179001395 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 483179001396 dimer interface [polypeptide binding]; other site 483179001397 active site 483179001398 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 483179001399 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 483179001400 dimerization interface [polypeptide binding]; other site 483179001401 Uncharacterized stress-induced protein [Function unknown]; Region: COG1561 483179001402 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 483179001403 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 483179001404 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 483179001405 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 483179001406 catalytic site [active] 483179001407 G-X2-G-X-G-K; other site 483179001408 protease TldD; Provisional; Region: tldD; PRK10735 483179001409 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 483179001410 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 483179001411 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 483179001412 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 483179001413 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 483179001414 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 483179001415 Subunit I/III interface [polypeptide binding]; other site 483179001416 D-pathway; other site 483179001417 Subunit I/VIIc interface [polypeptide binding]; other site 483179001418 Subunit I/IV interface [polypeptide binding]; other site 483179001419 Subunit I/II interface [polypeptide binding]; other site 483179001420 Low-spin heme (heme a) binding site [chemical binding]; other site 483179001421 Subunit I/VIIa interface [polypeptide binding]; other site 483179001422 Subunit I/VIa interface [polypeptide binding]; other site 483179001423 Dimer interface; other site 483179001424 Putative water exit pathway; other site 483179001425 Binuclear center (heme a3/CuB) [ion binding]; other site 483179001426 K-pathway; other site 483179001427 Subunit I/Vb interface [polypeptide binding]; other site 483179001428 Putative proton exit pathway; other site 483179001429 Subunit I/VIb interface; other site 483179001430 Subunit I/VIc interface [polypeptide binding]; other site 483179001431 Electron transfer pathway; other site 483179001432 Subunit I/VIIIb interface [polypeptide binding]; other site 483179001433 Subunit I/VIIb interface [polypeptide binding]; other site 483179001434 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 483179001435 UbiA prenyltransferase family; Region: UbiA; pfam01040 483179001436 Cytochrome oxidase assembly factor [Posttranslational modification, protein turnover, chaperones]; Region: COX11; COG3175 483179001437 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 483179001438 Subunit III/VIIa interface [polypeptide binding]; other site 483179001439 Phospholipid binding site [chemical binding]; other site 483179001440 Subunit I/III interface [polypeptide binding]; other site 483179001441 Subunit III/VIb interface [polypeptide binding]; other site 483179001442 Subunit III/VIa interface; other site 483179001443 Subunit III/Vb interface [polypeptide binding]; other site 483179001444 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349 483179001445 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 483179001446 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 483179001447 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 483179001448 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 483179001449 putative active site [active] 483179001450 putative substrate binding site [chemical binding]; other site 483179001451 ATP binding site [chemical binding]; other site 483179001452 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 483179001453 RNA/DNA hybrid binding site [nucleotide binding]; other site 483179001454 active site 483179001455 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 483179001456 catalytic triad [active] 483179001457 dimer interface [polypeptide binding]; other site 483179001458 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 483179001459 hypothetical protein; Validated; Region: PRK00228 483179001460 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 483179001461 PAS fold; Region: PAS_3; pfam08447 483179001462 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 483179001463 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 483179001464 metal binding site [ion binding]; metal-binding site 483179001465 active site 483179001466 I-site; other site 483179001467 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 483179001468 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 483179001469 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 483179001470 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 483179001471 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 483179001472 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 483179001473 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 483179001474 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 483179001475 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483179001476 catalytic residue [active] 483179001477 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 483179001478 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 483179001479 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 483179001480 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 483179001481 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 483179001482 active site 483179001483 motif I; other site 483179001484 motif II; other site 483179001485 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 483179001486 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 483179001487 Cl- selectivity filter; other site 483179001488 Cl- binding residues [ion binding]; other site 483179001489 pore gating glutamate residue; other site 483179001490 dimer interface [polypeptide binding]; other site 483179001491 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 483179001492 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 483179001493 DNA methylase; Region: N6_N4_Mtase; pfam01555 483179001494 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 483179001495 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 483179001496 motif II; other site 483179001497 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 483179001498 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 483179001499 minor groove reading motif; other site 483179001500 helix-hairpin-helix signature motif; other site 483179001501 substrate binding pocket [chemical binding]; other site 483179001502 active site 483179001503 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 483179001504 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 483179001505 DNA binding and oxoG recognition site [nucleotide binding] 483179001506 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5389 483179001507 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 483179001508 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 483179001509 catalytic residues [active] 483179001510 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 483179001511 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 483179001512 Walker A/P-loop; other site 483179001513 ATP binding site [chemical binding]; other site 483179001514 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 483179001515 ABC transporter signature motif; other site 483179001516 Walker B; other site 483179001517 D-loop; other site 483179001518 H-loop/switch region; other site 483179001519 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 483179001520 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 483179001521 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 483179001522 pyruvate phosphate dikinase; Provisional; Region: PRK09279 483179001523 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 483179001524 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 483179001525 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 483179001526 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 483179001527 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 483179001528 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 483179001529 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 483179001530 ureidoglycolate hydrolase; Provisional; Region: PRK03606 483179001531 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 483179001532 active site 483179001533 homotetramer interface [polypeptide binding]; other site 483179001534 Protein of unknown function (DUF2793); Region: DUF2793; pfam10983 483179001535 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 483179001536 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 483179001537 NAD(P) binding site [chemical binding]; other site 483179001538 homodimer interface [polypeptide binding]; other site 483179001539 substrate binding site [chemical binding]; other site 483179001540 active site 483179001541 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 483179001542 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 483179001543 Homeodomain-like domain; Region: HTH_23; cl17451 483179001544 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 483179001545 Integrase core domain; Region: rve_3; pfam13683 483179001546 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 483179001547 HTH-like domain; Region: HTH_21; pfam13276 483179001548 Integrase core domain; Region: rve; pfam00665 483179001549 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 483179001550 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 483179001551 active site 483179001552 substrate binding site [chemical binding]; other site 483179001553 cosubstrate binding site; other site 483179001554 catalytic site [active] 483179001555 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 483179001556 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 483179001557 Walker A/P-loop; other site 483179001558 ATP binding site [chemical binding]; other site 483179001559 Q-loop/lid; other site 483179001560 ABC transporter signature motif; other site 483179001561 Walker B; other site 483179001562 D-loop; other site 483179001563 H-loop/switch region; other site 483179001564 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 483179001565 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 483179001566 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 483179001567 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 483179001568 inhibitor-cofactor binding pocket; inhibition site 483179001569 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483179001570 catalytic residue [active] 483179001571 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 483179001572 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 483179001573 NADP-binding site; other site 483179001574 homotetramer interface [polypeptide binding]; other site 483179001575 substrate binding site [chemical binding]; other site 483179001576 homodimer interface [polypeptide binding]; other site 483179001577 active site 483179001578 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 483179001579 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 483179001580 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 483179001581 Integrase core domain; Region: rve; pfam00665 483179001582 DDE domain; Region: DDE_Tnp_IS240; pfam13610 483179001583 Integrase core domain; Region: rve_3; pfam13683 483179001584 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 483179001585 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 483179001586 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 483179001587 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 483179001588 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 483179001589 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 483179001590 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 483179001591 Integrase core domain; Region: rve; pfam00665 483179001592 Integrase core domain; Region: rve; pfam00665 483179001593 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 483179001594 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 483179001595 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 483179001596 Integrase core domain; Region: rve_3; cl15866 483179001597 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 483179001598 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 483179001599 active site 483179001600 substrate binding site [chemical binding]; other site 483179001601 metal binding site [ion binding]; metal-binding site 483179001602 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 483179001603 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 483179001604 Substrate binding site; other site 483179001605 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 483179001606 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 483179001607 dimerization interface [polypeptide binding]; other site 483179001608 putative active cleft [active] 483179001609 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 483179001610 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 483179001611 putative ADP-binding pocket [chemical binding]; other site 483179001612 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 483179001613 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 483179001614 Walker A/P-loop; other site 483179001615 ATP binding site [chemical binding]; other site 483179001616 Q-loop/lid; other site 483179001617 ABC transporter signature motif; other site 483179001618 Walker B; other site 483179001619 D-loop; other site 483179001620 H-loop/switch region; other site 483179001621 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 483179001622 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 483179001623 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 483179001624 TM-ABC transporter signature motif; other site 483179001625 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 483179001626 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_3; cd06311 483179001627 putative ligand binding site [chemical binding]; other site 483179001628 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 483179001629 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 483179001630 Metal-binding active site; metal-binding site 483179001631 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 483179001632 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 483179001633 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 483179001634 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 483179001635 xylose isomerase; Provisional; Region: PRK05474 483179001636 xylose isomerase; Region: xylose_isom_A; TIGR02630 483179001637 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 483179001638 N- and C-terminal domain interface [polypeptide binding]; other site 483179001639 D-xylulose kinase; Region: XylB; TIGR01312 483179001640 active site 483179001641 MgATP binding site [chemical binding]; other site 483179001642 catalytic site [active] 483179001643 metal binding site [ion binding]; metal-binding site 483179001644 xylulose binding site [chemical binding]; other site 483179001645 homodimer interface [polypeptide binding]; other site 483179001646 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 483179001647 DNA binding site [nucleotide binding] 483179001648 domain linker motif; other site 483179001649 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 483179001650 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 483179001651 putative ligand binding site [chemical binding]; other site 483179001652 Helix-turn-helix domain; Region: HTH_18; pfam12833 483179001653 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 483179001654 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 483179001655 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 483179001656 NAD(P) binding site [chemical binding]; other site 483179001657 catalytic residues [active] 483179001658 choline dehydrogenase; Validated; Region: PRK02106 483179001659 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 483179001660 transcriptional regulator BetI; Validated; Region: PRK00767 483179001661 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 483179001662 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 483179001663 L-asparaginase II [Amino acid transport and metabolism]; Region: AnsA; COG4448 483179001664 transcription elongation factor regulatory protein; Validated; Region: PRK06342 483179001665 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 483179001666 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 483179001667 putative addiction module antidote; Region: doc_partner; TIGR02609 483179001668 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 483179001669 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 483179001670 Cl binding site [ion binding]; other site 483179001671 oligomer interface [polypeptide binding]; other site 483179001672 Transcriptional regulators [Transcription]; Region: FadR; COG2186 483179001673 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 483179001674 DNA-binding site [nucleotide binding]; DNA binding site 483179001675 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 483179001676 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 483179001677 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483179001678 putative substrate translocation pore; other site 483179001679 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 483179001680 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 483179001681 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 483179001682 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 483179001683 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 483179001684 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 483179001685 motif II; other site 483179001686 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 483179001687 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 483179001688 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 483179001689 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 483179001690 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 483179001691 Predicted transcriptional regulator [Transcription]; Region: COG4957 483179001692 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 483179001693 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 483179001694 DnaA box-binding interface [nucleotide binding]; other site 483179001695 amidase; Validated; Region: PRK05962 483179001696 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 483179001697 Flavin Reductases; Region: FlaRed; cl00801 483179001698 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 483179001699 putative active site [active] 483179001700 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483179001701 heme pocket [chemical binding]; other site 483179001702 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483179001703 dimer interface [polypeptide binding]; other site 483179001704 phosphorylation site [posttranslational modification] 483179001705 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483179001706 ATP binding site [chemical binding]; other site 483179001707 Mg2+ binding site [ion binding]; other site 483179001708 G-X-G motif; other site 483179001709 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 483179001710 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 483179001711 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 483179001712 Uncharacterized conserved protein [Function unknown]; Region: COG5447 483179001713 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330 483179001714 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 483179001715 Predicted integral membrane protein [Function unknown]; Region: COG5436 483179001716 Uncharacterized conserved protein [Function unknown]; Region: COG5402 483179001717 Transglycosylase; Region: Transgly; pfam00912 483179001718 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 483179001719 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 483179001720 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 483179001721 Uncharacterized conserved protein [Function unknown]; Region: COG5323 483179001722 Terminase-like family; Region: Terminase_6; pfam03237 483179001723 Phage-related protein [Function unknown]; Region: COG4695 483179001724 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 483179001725 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 483179001726 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 483179001727 Phage capsid family; Region: Phage_capsid; pfam05065 483179001728 phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215 483179001729 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 483179001730 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 483179001731 oligomerization interface [polypeptide binding]; other site 483179001732 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 483179001733 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 483179001734 Predicted secreted protein [Function unknown]; Region: COG5437 483179001735 Protein of unknown function (DUF3356); Region: DUF3356; pfam11836 483179001736 Conserved hypothetical phage protein (DUF2376); Region: DUF2376; pfam09550 483179001737 Phage-related minor tail protein [Function unknown]; Region: COG5281 483179001738 TIGR02217 family protein; Region: chp_TIGR02217 483179001739 Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931 483179001740 phage conserved hypothetical protein BR0599; Region: phg_TIGR02218 483179001741 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 483179001742 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 483179001743 putative phage cell wall peptidase, NlpC/P60 family; Region: phage_NlpC_fam; TIGR02219 483179001744 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 483179001745 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483179001746 active site 483179001747 phosphorylation site [posttranslational modification] 483179001748 intermolecular recognition site; other site 483179001749 dimerization interface [polypeptide binding]; other site 483179001750 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 483179001751 DNA binding site [nucleotide binding] 483179001752 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483179001753 HAMP domain; Region: HAMP; pfam00672 483179001754 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483179001755 ATP binding site [chemical binding]; other site 483179001756 Mg2+ binding site [ion binding]; other site 483179001757 G-X-G motif; other site 483179001758 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 483179001759 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 483179001760 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 483179001761 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 483179001762 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 483179001763 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 483179001764 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 483179001765 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 483179001766 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 483179001767 protein binding site [polypeptide binding]; other site 483179001768 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 483179001769 protein binding site [polypeptide binding]; other site 483179001770 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 483179001771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483179001772 active site 483179001773 phosphorylation site [posttranslational modification] 483179001774 intermolecular recognition site; other site 483179001775 dimerization interface [polypeptide binding]; other site 483179001776 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 483179001777 DNA binding site [nucleotide binding] 483179001778 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483179001779 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 483179001780 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483179001781 dimerization interface [polypeptide binding]; other site 483179001782 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483179001783 dimer interface [polypeptide binding]; other site 483179001784 phosphorylation site [posttranslational modification] 483179001785 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483179001786 ATP binding site [chemical binding]; other site 483179001787 Mg2+ binding site [ion binding]; other site 483179001788 G-X-G motif; other site 483179001789 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 483179001790 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 483179001791 metal binding triad; other site 483179001792 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 483179001793 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 483179001794 metal binding triad; other site 483179001795 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 483179001796 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 483179001797 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298 483179001798 O-Antigen ligase; Region: Wzy_C; pfam04932 483179001799 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483179001800 PAS fold; Region: PAS_3; pfam08447 483179001801 putative active site [active] 483179001802 heme pocket [chemical binding]; other site 483179001803 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 483179001804 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483179001805 dimer interface [polypeptide binding]; other site 483179001806 phosphorylation site [posttranslational modification] 483179001807 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483179001808 ATP binding site [chemical binding]; other site 483179001809 Mg2+ binding site [ion binding]; other site 483179001810 G-X-G motif; other site 483179001811 aminopeptidase N; Provisional; Region: pepN; PRK14015 483179001812 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 483179001813 active site 483179001814 Zn binding site [ion binding]; other site 483179001815 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 483179001816 EamA-like transporter family; Region: EamA; pfam00892 483179001817 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483179001818 Major Facilitator Superfamily; Region: MFS_1; pfam07690 483179001819 putative substrate translocation pore; other site 483179001820 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 483179001821 Fe-S cluster binding site [ion binding]; other site 483179001822 active site 483179001823 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 483179001824 hydroxyglutarate oxidase; Provisional; Region: PRK11728 483179001825 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 483179001826 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3021 483179001827 putative catalytic site [active] 483179001828 putative metal binding site [ion binding]; other site 483179001829 putative phosphate binding site [ion binding]; other site 483179001830 AMP nucleosidase; Provisional; Region: PRK08292 483179001831 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 483179001832 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 483179001833 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 483179001834 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 483179001835 C-terminal domain interface [polypeptide binding]; other site 483179001836 GSH binding site (G-site) [chemical binding]; other site 483179001837 dimer interface [polypeptide binding]; other site 483179001838 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 483179001839 N-terminal domain interface [polypeptide binding]; other site 483179001840 putative dimer interface [polypeptide binding]; other site 483179001841 active site 483179001842 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4731 483179001843 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 483179001844 Uncharacterized conserved protein [Function unknown]; Region: COG1284 483179001845 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 483179001846 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 483179001847 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 483179001848 histidinol-phosphate aminotransferase; Provisional; Region: PRK08153 483179001849 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 483179001850 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483179001851 homodimer interface [polypeptide binding]; other site 483179001852 catalytic residue [active] 483179001853 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 483179001854 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 483179001855 active site 483179001856 DNA binding site [nucleotide binding] 483179001857 Int/Topo IB signature motif; other site 483179001858 Porin subfamily; Region: Porin_2; pfam02530 483179001859 Porin subfamily; Region: Porin_2; pfam02530 483179001860 Uncharacterized conserved protein [Function unknown]; Region: COG3743 483179001861 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 483179001862 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 483179001863 N-acetyl-D-glucosamine binding site [chemical binding]; other site 483179001864 catalytic residue [active] 483179001865 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 483179001866 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 483179001867 dimer interface [polypeptide binding]; other site 483179001868 active site 483179001869 catalytic residue [active] 483179001870 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 483179001871 SmpB-tmRNA interface; other site 483179001872 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 483179001873 Fe-S cluster binding site [ion binding]; other site 483179001874 DNA binding site [nucleotide binding] 483179001875 active site 483179001876 Uncharacterized conserved protein [Function unknown]; Region: COG1432 483179001877 LabA_like proteins; Region: LabA; cd10911 483179001878 putative metal binding site [ion binding]; other site 483179001879 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 483179001880 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 483179001881 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 483179001882 Zn2+ binding site [ion binding]; other site 483179001883 Mg2+ binding site [ion binding]; other site 483179001884 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 483179001885 synthetase active site [active] 483179001886 NTP binding site [chemical binding]; other site 483179001887 metal binding site [ion binding]; metal-binding site 483179001888 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 483179001889 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 483179001890 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 483179001891 active site 483179001892 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 483179001893 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 483179001894 ligand binding site [chemical binding]; other site 483179001895 flexible hinge region; other site 483179001896 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 483179001897 putative switch regulator; other site 483179001898 non-specific DNA interactions [nucleotide binding]; other site 483179001899 DNA binding site [nucleotide binding] 483179001900 sequence specific DNA binding site [nucleotide binding]; other site 483179001901 putative cAMP binding site [chemical binding]; other site 483179001902 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483179001903 Major Facilitator Superfamily; Region: MFS_1; pfam07690 483179001904 putative substrate translocation pore; other site 483179001905 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 483179001906 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 483179001907 Helix-turn-helix domain; Region: HTH_18; pfam12833 483179001908 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 483179001909 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3216 483179001910 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 483179001911 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 483179001912 Catalytic site [active] 483179001913 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 483179001914 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 483179001915 ribonuclease III; Reviewed; Region: PRK12371 483179001916 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 483179001917 dimerization interface [polypeptide binding]; other site 483179001918 active site 483179001919 metal binding site [ion binding]; metal-binding site 483179001920 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 483179001921 dsRNA binding site [nucleotide binding]; other site 483179001922 GTPase Era; Reviewed; Region: era; PRK00089 483179001923 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 483179001924 G1 box; other site 483179001925 GTP/Mg2+ binding site [chemical binding]; other site 483179001926 Switch I region; other site 483179001927 G2 box; other site 483179001928 Switch II region; other site 483179001929 G3 box; other site 483179001930 G4 box; other site 483179001931 G5 box; other site 483179001932 KH domain; Region: KH_2; pfam07650 483179001933 Recombination protein O N terminal; Region: RecO_N; pfam11967 483179001934 DNA repair protein RecO; Region: reco; TIGR00613 483179001935 Recombination protein O C terminal; Region: RecO_C; pfam02565 483179001936 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 483179001937 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 483179001938 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 483179001939 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 483179001940 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 483179001941 dihydroorotase; Validated; Region: PRK09060 483179001942 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 483179001943 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 483179001944 active site 483179001945 TIGR02301 family protein; Region: TIGR02301 483179001946 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 483179001947 nudix motif; other site 483179001948 Uncharacterized conserved protein [Function unknown]; Region: COG2135 483179001949 Lysine efflux permease [General function prediction only]; Region: COG1279 483179001950 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 483179001951 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 483179001952 active site 483179001953 HIGH motif; other site 483179001954 nucleotide binding site [chemical binding]; other site 483179001955 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 483179001956 KMSKS motif; other site 483179001957 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 483179001958 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 483179001959 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 483179001960 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 483179001961 active site 483179001962 catalytic residues [active] 483179001963 metal binding site [ion binding]; metal-binding site 483179001964 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 483179001965 Predicted permeases [General function prediction only]; Region: RarD; COG2962 483179001966 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 483179001967 Peptidase family M23; Region: Peptidase_M23; pfam01551 483179001968 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 483179001969 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483179001970 S-adenosylmethionine binding site [chemical binding]; other site 483179001971 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312 483179001972 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 483179001973 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 483179001974 SurA N-terminal domain; Region: SurA_N; pfam09312 483179001975 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 483179001976 OstA-like protein; Region: OstA; cl00844 483179001977 Organic solvent tolerance protein; Region: OstA_C; pfam04453 483179001978 Predicted permeases [General function prediction only]; Region: COG0795 483179001979 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 483179001980 Predicted permeases [General function prediction only]; Region: COG0795 483179001981 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 483179001982 multifunctional aminopeptidase A; Provisional; Region: PRK00913 483179001983 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 483179001984 interface (dimer of trimers) [polypeptide binding]; other site 483179001985 Substrate-binding/catalytic site; other site 483179001986 Zn-binding sites [ion binding]; other site 483179001987 DNA polymerase III subunit chi; Validated; Region: PRK05728 483179001988 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 483179001989 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 483179001990 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483179001991 Walker A/P-loop; other site 483179001992 ATP binding site [chemical binding]; other site 483179001993 ABC transporter signature motif; other site 483179001994 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 483179001995 Walker B; other site 483179001996 D-loop; other site 483179001997 ABC transporter; Region: ABC_tran_2; pfam12848 483179001998 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 483179001999 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 483179002000 DinB superfamily; Region: DinB_2; pfam12867 483179002001 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 483179002002 active site 483179002003 multimer interface [polypeptide binding]; other site 483179002004 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 483179002005 Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187 483179002006 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 483179002007 MoaE homodimer interface [polypeptide binding]; other site 483179002008 MoaD interaction [polypeptide binding]; other site 483179002009 active site residues [active] 483179002010 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 483179002011 MoaE interaction surface [polypeptide binding]; other site 483179002012 MoeB interaction surface [polypeptide binding]; other site 483179002013 thiocarboxylated glycine; other site 483179002014 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 483179002015 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 483179002016 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 483179002017 GIY-YIG motif/motif A; other site 483179002018 active site 483179002019 catalytic site [active] 483179002020 putative DNA binding site [nucleotide binding]; other site 483179002021 metal binding site [ion binding]; metal-binding site 483179002022 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 483179002023 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 483179002024 short chain dehydrogenase; Provisional; Region: PRK09134 483179002025 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 483179002026 NADP binding site [chemical binding]; other site 483179002027 substrate binding pocket [chemical binding]; other site 483179002028 active site 483179002029 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 483179002030 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 483179002031 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 483179002032 putative C-terminal domain interface [polypeptide binding]; other site 483179002033 putative GSH binding site (G-site) [chemical binding]; other site 483179002034 putative dimer interface [polypeptide binding]; other site 483179002035 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 483179002036 dimer interface [polypeptide binding]; other site 483179002037 N-terminal domain interface [polypeptide binding]; other site 483179002038 putative substrate binding pocket (H-site) [chemical binding]; other site 483179002039 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 483179002040 B1 nucleotide binding pocket [chemical binding]; other site 483179002041 B2 nucleotide binding pocket [chemical binding]; other site 483179002042 CAS motifs; other site 483179002043 active site 483179002044 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 483179002045 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 483179002046 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 483179002047 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 483179002048 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 483179002049 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 483179002050 putative [4Fe-4S] binding site [ion binding]; other site 483179002051 putative molybdopterin cofactor binding site [chemical binding]; other site 483179002052 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 483179002053 putative molybdopterin cofactor binding site; other site 483179002054 Protein of unknown function (DUF992); Region: DUF992; pfam06186 483179002055 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 483179002056 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 483179002057 active site 483179002058 substrate binding site [chemical binding]; other site 483179002059 cosubstrate binding site; other site 483179002060 catalytic site [active] 483179002061 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 483179002062 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 483179002063 dimerization interface [polypeptide binding]; other site 483179002064 putative ATP binding site [chemical binding]; other site 483179002065 Domain of unknown function DUF20; Region: UPF0118; pfam01594 483179002066 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 483179002067 hypothetical protein; Validated; Region: PRK09087 483179002068 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 483179002069 Walker A motif; other site 483179002070 ATP binding site [chemical binding]; other site 483179002071 Walker B motif; other site 483179002072 arginine finger; other site 483179002073 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483179002074 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 483179002075 NAD(P) binding site [chemical binding]; other site 483179002076 active site 483179002077 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 483179002078 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 483179002079 putative NAD(P) binding site [chemical binding]; other site 483179002080 putative active site [active] 483179002081 L-lactate permease; Region: Lactate_perm; cl00701 483179002082 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 483179002083 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 483179002084 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 483179002085 active site 483179002086 catalytic site [active] 483179002087 substrate binding site [chemical binding]; other site 483179002088 Archaeal adenylate kinase [Nucleotide transport and metabolism]; Region: AdkA; COG2019 483179002089 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 483179002090 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 483179002091 non-specific DNA binding site [nucleotide binding]; other site 483179002092 salt bridge; other site 483179002093 sequence-specific DNA binding site [nucleotide binding]; other site 483179002094 Uncharacterized conserved protein [Function unknown]; Region: COG4933 483179002095 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 483179002096 Integrase core domain; Region: rve; pfam00665 483179002097 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 483179002098 AAA domain; Region: AAA_22; pfam13401 483179002099 AAA ATPase domain; Region: AAA_16; pfam13191 483179002100 TniQ; Region: TniQ; pfam06527 483179002101 Domain of unknown function (DUF955); Region: DUF955; pfam06114 483179002102 Uncharacterized protein containing a TIR (Toll-Interleukin 1-resistance) domain [Function unknown]; Region: COG4916 483179002103 TIR domain; Region: TIR_2; pfam13676 483179002104 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 483179002105 Bacterial SH3 domain; Region: SH3_3; pfam08239 483179002106 cystathionine beta-lyase; Provisional; Region: PRK05967 483179002107 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 483179002108 homodimer interface [polypeptide binding]; other site 483179002109 substrate-cofactor binding pocket; other site 483179002110 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483179002111 catalytic residue [active] 483179002112 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 483179002113 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 483179002114 active site 483179002115 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 483179002116 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 483179002117 substrate binding pocket [chemical binding]; other site 483179002118 membrane-bound complex binding site; other site 483179002119 hinge residues; other site 483179002120 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 483179002121 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179002122 conserved gate region; other site 483179002123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179002124 putative PBP binding loops; other site 483179002125 dimer interface [polypeptide binding]; other site 483179002126 ABC-ATPase subunit interface; other site 483179002127 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 483179002128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179002129 dimer interface [polypeptide binding]; other site 483179002130 conserved gate region; other site 483179002131 putative PBP binding loops; other site 483179002132 ABC-ATPase subunit interface; other site 483179002133 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 483179002134 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 483179002135 Walker A/P-loop; other site 483179002136 ATP binding site [chemical binding]; other site 483179002137 Q-loop/lid; other site 483179002138 ABC transporter signature motif; other site 483179002139 Walker B; other site 483179002140 D-loop; other site 483179002141 H-loop/switch region; other site 483179002142 salicylate hydroxylase; Provisional; Region: PRK06475 483179002143 salicylate hydroxylase; Provisional; Region: PRK08163 483179002144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391 483179002145 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 483179002146 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 483179002147 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 483179002148 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 483179002149 catalytic site [active] 483179002150 putative active site [active] 483179002151 putative substrate binding site [chemical binding]; other site 483179002152 HRDC domain; Region: HRDC; pfam00570 483179002153 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 483179002154 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 483179002155 dimer interface [polypeptide binding]; other site 483179002156 anticodon binding site; other site 483179002157 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 483179002158 homodimer interface [polypeptide binding]; other site 483179002159 motif 1; other site 483179002160 active site 483179002161 motif 2; other site 483179002162 GAD domain; Region: GAD; pfam02938 483179002163 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 483179002164 active site 483179002165 motif 3; other site 483179002166 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 483179002167 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 483179002168 CAP-like domain; other site 483179002169 active site 483179002170 primary dimer interface [polypeptide binding]; other site 483179002171 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 483179002172 Putative arginyl-tRNA:protein arginylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG2935 483179002173 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 483179002174 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 483179002175 Predicted membrane protein/domain [Function unknown]; Region: COG1714 483179002176 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 483179002177 dimer interface [polypeptide binding]; other site 483179002178 allosteric magnesium binding site [ion binding]; other site 483179002179 active site 483179002180 aspartate-rich active site metal binding site; other site 483179002181 Schiff base residues; other site 483179002182 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 483179002183 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 483179002184 substrate binding site [chemical binding]; other site 483179002185 oxyanion hole (OAH) forming residues; other site 483179002186 trimer interface [polypeptide binding]; other site 483179002187 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 483179002188 Transcriptional regulators [Transcription]; Region: MarR; COG1846 483179002189 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 483179002190 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 483179002191 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 483179002192 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 483179002193 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 483179002194 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 483179002195 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 483179002196 dimer interface [polypeptide binding]; other site 483179002197 active site 483179002198 glycine-pyridoxal phosphate binding site [chemical binding]; other site 483179002199 folate binding site [chemical binding]; other site 483179002200 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 483179002201 ATP cone domain; Region: ATP-cone; pfam03477 483179002202 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 483179002203 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 483179002204 catalytic motif [active] 483179002205 Zn binding site [ion binding]; other site 483179002206 RibD C-terminal domain; Region: RibD_C; cl17279 483179002207 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 483179002208 Lumazine binding domain; Region: Lum_binding; pfam00677 483179002209 Lumazine binding domain; Region: Lum_binding; pfam00677 483179002210 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 483179002211 homopentamer interface [polypeptide binding]; other site 483179002212 active site 483179002213 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 483179002214 putative RNA binding site [nucleotide binding]; other site 483179002215 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; COG3808 483179002216 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 483179002217 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 483179002218 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 483179002219 Uncharacterized conserved protein [Function unknown]; Region: COG5452 483179002220 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 483179002221 putative phosphate acyltransferase; Provisional; Region: PRK05331 483179002222 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 483179002223 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 483179002224 dimer interface [polypeptide binding]; other site 483179002225 active site 483179002226 CoA binding pocket [chemical binding]; other site 483179002227 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 483179002228 IHF dimer interface [polypeptide binding]; other site 483179002229 IHF - DNA interface [nucleotide binding]; other site 483179002230 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 483179002231 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 483179002232 DNA binding residues [nucleotide binding] 483179002233 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 483179002234 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 483179002235 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 483179002236 SLBB domain; Region: SLBB; pfam10531 483179002237 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 483179002238 Protein of unknown function (DUF2842); Region: DUF2842; pfam11003 483179002239 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 483179002240 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 483179002241 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 483179002242 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 483179002243 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 483179002244 oligomer interface [polypeptide binding]; other site 483179002245 putative active site [active] 483179002246 Mn binding site [ion binding]; other site 483179002247 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 483179002248 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 483179002249 23S rRNA interface [nucleotide binding]; other site 483179002250 L3 interface [polypeptide binding]; other site 483179002251 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 483179002252 CoenzymeA binding site [chemical binding]; other site 483179002253 subunit interaction site [polypeptide binding]; other site 483179002254 PHB binding site; other site 483179002255 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994 483179002256 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 483179002257 homodimer interface [polypeptide binding]; other site 483179002258 substrate-cofactor binding pocket; other site 483179002259 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483179002260 catalytic residue [active] 483179002261 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 483179002262 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 483179002263 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 483179002264 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 483179002265 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 483179002266 NADH dehydrogenase subunit D; Validated; Region: PRK06075 483179002267 NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905 483179002268 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 483179002269 putative dimer interface [polypeptide binding]; other site 483179002270 [2Fe-2S] cluster binding site [ion binding]; other site 483179002271 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 483179002272 SLBB domain; Region: SLBB; pfam10531 483179002273 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 483179002274 NADH dehydrogenase subunit G; Validated; Region: PRK09130 483179002275 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 483179002276 catalytic loop [active] 483179002277 iron binding site [ion binding]; other site 483179002278 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 483179002279 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 483179002280 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 483179002281 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 483179002282 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 483179002283 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 483179002284 4Fe-4S binding domain; Region: Fer4; pfam00037 483179002285 4Fe-4S binding domain; Region: Fer4; pfam00037 483179002286 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 483179002287 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 483179002288 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 483179002289 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 483179002290 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 483179002291 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 483179002292 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 483179002293 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 483179002294 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 483179002295 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 483179002296 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 483179002297 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 483179002298 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 483179002299 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 483179002300 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 483179002301 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 483179002302 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 483179002303 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 483179002304 dimer interface [polypeptide binding]; other site 483179002305 substrate binding site [chemical binding]; other site 483179002306 metal binding site [ion binding]; metal-binding site 483179002307 Predicted secreted protein [Function unknown]; Region: COG5454 483179002308 prolyl-tRNA synthetase; Provisional; Region: PRK12325 483179002309 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 483179002310 dimer interface [polypeptide binding]; other site 483179002311 motif 1; other site 483179002312 active site 483179002313 motif 2; other site 483179002314 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 483179002315 active site 483179002316 motif 3; other site 483179002317 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 483179002318 anticodon binding site; other site 483179002319 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 483179002320 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 483179002321 FtsX-like permease family; Region: FtsX; pfam02687 483179002322 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 483179002323 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 483179002324 Walker A/P-loop; other site 483179002325 ATP binding site [chemical binding]; other site 483179002326 Q-loop/lid; other site 483179002327 ABC transporter signature motif; other site 483179002328 Walker B; other site 483179002329 D-loop; other site 483179002330 H-loop/switch region; other site 483179002331 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 483179002332 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 483179002333 putative active site [active] 483179002334 putative PHP Thumb interface [polypeptide binding]; other site 483179002335 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 483179002336 generic binding surface II; other site 483179002337 generic binding surface I; other site 483179002338 Protein of unknwon function (DUF3008); Region: DUF3008; pfam11450 483179002339 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 483179002340 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 483179002341 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 483179002342 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 483179002343 RNA binding surface [nucleotide binding]; other site 483179002344 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 483179002345 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 483179002346 Ligand Binding Site [chemical binding]; other site 483179002347 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 483179002348 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 483179002349 active site 483179002350 putative lithium-binding site [ion binding]; other site 483179002351 substrate binding site [chemical binding]; other site 483179002352 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 483179002353 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483179002354 putative substrate translocation pore; other site 483179002355 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 483179002356 putative GSH binding site [chemical binding]; other site 483179002357 catalytic residues [active] 483179002358 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 483179002359 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 483179002360 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 483179002361 dimerization interface [polypeptide binding]; other site 483179002362 ATP binding site [chemical binding]; other site 483179002363 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 483179002364 dimerization interface [polypeptide binding]; other site 483179002365 ATP binding site [chemical binding]; other site 483179002366 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 483179002367 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 483179002368 C-terminal domain interface [polypeptide binding]; other site 483179002369 GSH binding site (G-site) [chemical binding]; other site 483179002370 dimer interface [polypeptide binding]; other site 483179002371 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 483179002372 N-terminal domain interface [polypeptide binding]; other site 483179002373 dimer interface [polypeptide binding]; other site 483179002374 substrate binding pocket (H-site) [chemical binding]; other site 483179002375 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 483179002376 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 483179002377 putative active site [active] 483179002378 catalytic triad [active] 483179002379 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 483179002380 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 483179002381 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 483179002382 ATP binding site [chemical binding]; other site 483179002383 active site 483179002384 substrate binding site [chemical binding]; other site 483179002385 Uncharacterized conserved protein [Function unknown]; Region: COG5467 483179002386 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 483179002387 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 483179002388 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 483179002389 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 483179002390 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 483179002391 putative metal binding site [ion binding]; other site 483179002392 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 483179002393 active site 483179002394 adenylosuccinate lyase; Provisional; Region: PRK07492 483179002395 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 483179002396 tetramer interface [polypeptide binding]; other site 483179002397 active site 483179002398 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 483179002399 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 483179002400 substrate binding site [chemical binding]; other site 483179002401 hexamer interface [polypeptide binding]; other site 483179002402 metal binding site [ion binding]; metal-binding site 483179002403 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 483179002404 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 483179002405 putative acyl-acceptor binding pocket; other site 483179002406 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 483179002407 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266 483179002408 putative NAD(P) binding site [chemical binding]; other site 483179002409 structural Zn binding site [ion binding]; other site 483179002410 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501 483179002411 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 483179002412 dimer interface [polypeptide binding]; other site 483179002413 active site 483179002414 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519 483179002415 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 483179002416 active site 483179002417 acyl carrier protein; Provisional; Region: PRK06508 483179002418 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 483179002419 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 483179002420 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 483179002421 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 483179002422 active site 483179002423 catalytic residues [active] 483179002424 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 483179002425 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 483179002426 substrate binding site [chemical binding]; other site 483179002427 ATP binding site [chemical binding]; other site 483179002428 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 483179002429 Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454 483179002430 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 483179002431 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 483179002432 active site 483179002433 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 483179002434 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 483179002435 active site 483179002436 motif I; other site 483179002437 motif II; other site 483179002438 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 483179002439 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 483179002440 FMN binding site [chemical binding]; other site 483179002441 active site 483179002442 catalytic residues [active] 483179002443 substrate binding site [chemical binding]; other site 483179002444 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 483179002445 cobalamin synthase; Reviewed; Region: cobS; PRK00235 483179002446 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 483179002447 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 483179002448 putative dimer interface [polypeptide binding]; other site 483179002449 active site pocket [active] 483179002450 putative cataytic base [active] 483179002451 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 483179002452 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 483179002453 putative DNA binding site [nucleotide binding]; other site 483179002454 putative Zn2+ binding site [ion binding]; other site 483179002455 AsnC family; Region: AsnC_trans_reg; pfam01037 483179002456 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 483179002457 putative uracil binding site [chemical binding]; other site 483179002458 putative active site [active] 483179002459 Staphylococcal nuclease homologues; Region: SNc; smart00318 483179002460 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 483179002461 Catalytic site; other site 483179002462 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 483179002463 Sel1-like repeats; Region: SEL1; smart00671 483179002464 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 483179002465 putative catalytic site [active] 483179002466 putative phosphate binding site [ion binding]; other site 483179002467 active site 483179002468 metal binding site A [ion binding]; metal-binding site 483179002469 DNA binding site [nucleotide binding] 483179002470 putative AP binding site [nucleotide binding]; other site 483179002471 putative metal binding site B [ion binding]; other site 483179002472 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 483179002473 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 483179002474 putative metal binding site [ion binding]; other site 483179002475 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 483179002476 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 483179002477 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 483179002478 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 483179002479 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 483179002480 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 483179002481 active site 483179002482 HIGH motif; other site 483179002483 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 483179002484 KMSK motif region; other site 483179002485 tRNA binding surface [nucleotide binding]; other site 483179002486 DALR anticodon binding domain; Region: DALR_1; smart00836 483179002487 anticodon binding site; other site 483179002488 Sporulation related domain; Region: SPOR; pfam05036 483179002489 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 483179002490 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 483179002491 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 483179002492 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 483179002493 twin arginine translocase protein A; Provisional; Region: tatA; PRK00720 483179002494 sec-independent translocase; Provisional; Region: PRK00708 483179002495 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 483179002496 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 483179002497 seryl-tRNA synthetase; Provisional; Region: PRK05431 483179002498 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 483179002499 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 483179002500 dimer interface [polypeptide binding]; other site 483179002501 active site 483179002502 motif 1; other site 483179002503 motif 2; other site 483179002504 motif 3; other site 483179002505 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 483179002506 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 483179002507 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483179002508 S-adenosylmethionine binding site [chemical binding]; other site 483179002509 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 483179002510 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 483179002511 Peptidase family M23; Region: Peptidase_M23; pfam01551 483179002512 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 483179002513 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483179002514 Walker A motif; other site 483179002515 ATP binding site [chemical binding]; other site 483179002516 Walker B motif; other site 483179002517 Preprotein translocase subunit YajC [Intracellular trafficking and secretion]; Region: YajC; COG1862 483179002518 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13023 483179002519 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 483179002520 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 483179002521 Protein export membrane protein; Region: SecD_SecF; pfam02355 483179002522 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 483179002523 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 483179002524 substrate binding pocket [chemical binding]; other site 483179002525 substrate-Mg2+ binding site; other site 483179002526 aspartate-rich region 1; other site 483179002527 aspartate-rich region 2; other site 483179002528 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 483179002529 Glucose inhibited division protein A; Region: GIDA; pfam01134 483179002530 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 483179002531 Predicted membrane protein [Function unknown]; Region: COG4872 483179002532 Uncharacterized membrane-anchored protein [Function unknown]; Region: COG4929 483179002533 trigger factor; Provisional; Region: tig; PRK01490 483179002534 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 483179002535 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 483179002536 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 483179002537 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 483179002538 GatB domain; Region: GatB_Yqey; smart00845 483179002539 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 483179002540 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 483179002541 NADH dehydrogenase; Validated; Region: PRK08183 483179002542 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4765 483179002543 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 483179002544 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 483179002545 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 483179002546 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 483179002547 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 483179002548 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 483179002549 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 483179002550 carboxyltransferase (CT) interaction site; other site 483179002551 biotinylation site [posttranslational modification]; other site 483179002552 Dehydroquinase class II; Region: DHquinase_II; pfam01220 483179002553 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 483179002554 trimer interface [polypeptide binding]; other site 483179002555 active site 483179002556 dimer interface [polypeptide binding]; other site 483179002557 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 483179002558 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 483179002559 catalytic residues [active] 483179002560 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 483179002561 Peptidase family M48; Region: Peptidase_M48; cl12018 483179002562 aspartate aminotransferase; Provisional; Region: PRK05764 483179002563 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 483179002564 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483179002565 homodimer interface [polypeptide binding]; other site 483179002566 catalytic residue [active] 483179002567 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 483179002568 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 483179002569 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 483179002570 AMIN domain; Region: AMIN; pfam11741 483179002571 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 483179002572 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 483179002573 active site 483179002574 metal binding site [ion binding]; metal-binding site 483179002575 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 483179002576 Transglycosylase; Region: Transgly; pfam00912 483179002577 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 483179002578 peptide chain release factor 2; Provisional; Region: PRK07342 483179002579 This domain is found in peptide chain release factors; Region: PCRF; smart00937 483179002580 RF-1 domain; Region: RF-1; pfam00472 483179002581 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 483179002582 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 483179002583 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 483179002584 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 483179002585 dinuclear metal binding motif [ion binding]; other site 483179002586 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 483179002587 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 483179002588 catalytic triad [active] 483179002589 AsmA family; Region: AsmA; pfam05170 483179002590 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 483179002591 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 483179002592 active site 483179002593 HIGH motif; other site 483179002594 dimer interface [polypeptide binding]; other site 483179002595 KMSKS motif; other site 483179002596 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 483179002597 RNA binding surface [nucleotide binding]; other site 483179002598 Predicted molecular chaperone distantly related to HSP70-fold metalloproteases [Posttranslational modification, protein turnover, chaperones]; Region: COG2377 483179002599 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 483179002600 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 483179002601 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 483179002602 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 483179002603 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 483179002604 catalytic residue [active] 483179002605 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 483179002606 putative ABC transporter; Region: ycf24; CHL00085 483179002607 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 483179002608 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 483179002609 Walker A/P-loop; other site 483179002610 ATP binding site [chemical binding]; other site 483179002611 Q-loop/lid; other site 483179002612 ABC transporter signature motif; other site 483179002613 Walker B; other site 483179002614 D-loop; other site 483179002615 H-loop/switch region; other site 483179002616 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 483179002617 FeS assembly protein SufD; Region: sufD; TIGR01981 483179002618 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 483179002619 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 483179002620 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 483179002621 catalytic residue [active] 483179002622 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 483179002623 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 483179002624 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 483179002625 active site 483179002626 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 483179002627 ATP-NAD kinase; Region: NAD_kinase; pfam01513 483179002628 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 483179002629 helicase 45; Provisional; Region: PTZ00424 483179002630 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 483179002631 ATP binding site [chemical binding]; other site 483179002632 Mg++ binding site [ion binding]; other site 483179002633 motif III; other site 483179002634 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 483179002635 nucleotide binding region [chemical binding]; other site 483179002636 ATP-binding site [chemical binding]; other site 483179002637 FeS assembly scaffold SufA; Region: sufA_proteo; TIGR01997 483179002638 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 483179002639 metal-binding site [ion binding] 483179002640 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 483179002641 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483179002642 S-adenosylmethionine binding site [chemical binding]; other site 483179002643 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 483179002644 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3827 483179002645 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 483179002646 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 483179002647 HIGH motif; other site 483179002648 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 483179002649 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 483179002650 active site 483179002651 KMSKS motif; other site 483179002652 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 483179002653 tRNA binding surface [nucleotide binding]; other site 483179002654 anticodon binding site; other site 483179002655 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 483179002656 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 483179002657 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 483179002658 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 483179002659 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 483179002660 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 483179002661 putative C-terminal domain interface [polypeptide binding]; other site 483179002662 putative GSH binding site (G-site) [chemical binding]; other site 483179002663 putative dimer interface [polypeptide binding]; other site 483179002664 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 483179002665 putative N-terminal domain interface [polypeptide binding]; other site 483179002666 putative dimer interface [polypeptide binding]; other site 483179002667 putative substrate binding pocket (H-site) [chemical binding]; other site 483179002668 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 483179002669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179002670 dimer interface [polypeptide binding]; other site 483179002671 conserved gate region; other site 483179002672 putative PBP binding loops; other site 483179002673 ABC-ATPase subunit interface; other site 483179002674 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 483179002675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179002676 dimer interface [polypeptide binding]; other site 483179002677 conserved gate region; other site 483179002678 putative PBP binding loops; other site 483179002679 ABC-ATPase subunit interface; other site 483179002680 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 483179002681 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 483179002682 substrate binding pocket [chemical binding]; other site 483179002683 membrane-bound complex binding site; other site 483179002684 hinge residues; other site 483179002685 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 483179002686 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 483179002687 FeS/SAM binding site; other site 483179002688 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 483179002689 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 483179002690 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 483179002691 hypothetical protein; Provisional; Region: PRK06753 483179002692 fumarate hydratase; Provisional; Region: PRK15389 483179002693 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 483179002694 Fumarase C-terminus; Region: Fumerase_C; pfam05683 483179002695 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 483179002696 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 483179002697 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 483179002698 Transglycosylase associated protein; Region: Transgly_assoc; pfam04226 483179002699 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 483179002700 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 483179002701 active site 483179002702 Int/Topo IB signature motif; other site 483179002703 catalytic residues [active] 483179002704 DNA binding site [nucleotide binding] 483179002705 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 483179002706 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 483179002707 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929 483179002708 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 483179002709 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 483179002710 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 483179002711 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 483179002712 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 483179002713 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 483179002714 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 483179002715 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 483179002716 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 483179002717 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 483179002718 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 483179002719 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 483179002720 ArsC family; Region: ArsC; pfam03960 483179002721 catalytic residues [active] 483179002722 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 483179002723 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 483179002724 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 483179002725 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 483179002726 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 483179002727 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 483179002728 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 483179002729 TMP-binding site; other site 483179002730 ATP-binding site [chemical binding]; other site 483179002731 DNA polymerase III subunit delta'; Validated; Region: PRK09112 483179002732 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 483179002733 DNA polymerase III subunit delta'; Validated; Region: PRK08485 483179002734 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 483179002735 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 483179002736 active site 483179002737 HIGH motif; other site 483179002738 KMSKS motif; other site 483179002739 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 483179002740 tRNA binding surface [nucleotide binding]; other site 483179002741 anticodon binding site; other site 483179002742 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 483179002743 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 483179002744 active site 483179002745 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 483179002746 putative hydrolase; Provisional; Region: PRK02113 483179002747 cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657 483179002748 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 483179002749 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483179002750 Walker A/P-loop; other site 483179002751 ATP binding site [chemical binding]; other site 483179002752 Q-loop/lid; other site 483179002753 ABC transporter signature motif; other site 483179002754 Walker B; other site 483179002755 D-loop; other site 483179002756 H-loop/switch region; other site 483179002757 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 483179002758 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 483179002759 active site 483179002760 EamA-like transporter family; Region: EamA; pfam00892 483179002761 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 483179002762 EamA-like transporter family; Region: EamA; pfam00892 483179002763 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 483179002764 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 483179002765 motif I; other site 483179002766 active site 483179002767 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 483179002768 motif II; other site 483179002769 Chaperone required for the assembly of the mitochondrial F1-ATPase [Posttranslational modification, protein turnover, chaperones]; Region: COG5387 483179002770 glutamine synthetase; Provisional; Region: glnA; PRK09469 483179002771 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 483179002772 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 483179002773 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 483179002774 Nitrogen regulatory protein P-II; Region: P-II; smart00938 483179002775 Uncharacterized conserved protein [Function unknown]; Region: COG0062 483179002776 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 483179002777 putative substrate binding site [chemical binding]; other site 483179002778 putative ATP binding site [chemical binding]; other site 483179002779 phosphoglycolate phosphatase; Provisional; Region: PRK13222 483179002780 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 483179002781 motif II; other site 483179002782 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 483179002783 tetramer (dimer of dimers) interface [polypeptide binding]; other site 483179002784 active site 483179002785 dimer interface [polypeptide binding]; other site 483179002786 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3184 483179002787 glutathione reductase; Validated; Region: PRK06116 483179002788 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 483179002789 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 483179002790 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 483179002791 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 483179002792 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 483179002793 NAD synthetase; Provisional; Region: PRK13981 483179002794 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 483179002795 multimer interface [polypeptide binding]; other site 483179002796 active site 483179002797 catalytic triad [active] 483179002798 protein interface 1 [polypeptide binding]; other site 483179002799 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 483179002800 homodimer interface [polypeptide binding]; other site 483179002801 NAD binding pocket [chemical binding]; other site 483179002802 ATP binding pocket [chemical binding]; other site 483179002803 Mg binding site [ion binding]; other site 483179002804 active-site loop [active] 483179002805 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 483179002806 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 483179002807 active site 483179002808 HIGH motif; other site 483179002809 nucleotide binding site [chemical binding]; other site 483179002810 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 483179002811 active site 483179002812 KMSKS motif; other site 483179002813 malic enzyme; Reviewed; Region: PRK12862 483179002814 Malic enzyme, N-terminal domain; Region: malic; pfam00390 483179002815 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 483179002816 putative NAD(P) binding site [chemical binding]; other site 483179002817 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 483179002818 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 483179002819 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 483179002820 active site 483179002821 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 483179002822 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 483179002823 Permease; Region: Permease; pfam02405 483179002824 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 483179002825 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 483179002826 Walker A/P-loop; other site 483179002827 ATP binding site [chemical binding]; other site 483179002828 Q-loop/lid; other site 483179002829 ABC transporter signature motif; other site 483179002830 Walker B; other site 483179002831 D-loop; other site 483179002832 H-loop/switch region; other site 483179002833 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 483179002834 mce related protein; Region: MCE; pfam02470 483179002835 ABC-type uncharacterized transport system, auxiliary component [General function prediction only]; Region: COG3218 483179002836 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 483179002837 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 483179002838 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 483179002839 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 483179002840 catalytic loop [active] 483179002841 iron binding site [ion binding]; other site 483179002842 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 483179002843 Predicted secreted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5661 483179002844 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 483179002845 dihydropteroate synthase; Region: DHPS; TIGR01496 483179002846 substrate binding pocket [chemical binding]; other site 483179002847 dimer interface [polypeptide binding]; other site 483179002848 inhibitor binding site; inhibition site 483179002849 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 483179002850 homooctamer interface [polypeptide binding]; other site 483179002851 active site 483179002852 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 483179002853 catalytic center binding site [active] 483179002854 ATP binding site [chemical binding]; other site 483179002855 Predicted membrane protein [Function unknown]; Region: COG3768 483179002856 Domain of unknown function (DUF697); Region: DUF697; cl12064 483179002857 Predicted ATPase [General function prediction only]; Region: COG3106 483179002858 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 483179002859 catalytic core [active] 483179002860 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 483179002861 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 483179002862 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483179002863 PAS domain; Region: PAS_9; pfam13426 483179002864 putative active site [active] 483179002865 heme pocket [chemical binding]; other site 483179002866 PAS fold; Region: PAS_4; pfam08448 483179002867 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483179002868 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483179002869 dimer interface [polypeptide binding]; other site 483179002870 phosphorylation site [posttranslational modification] 483179002871 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483179002872 ATP binding site [chemical binding]; other site 483179002873 Mg2+ binding site [ion binding]; other site 483179002874 G-X-G motif; other site 483179002875 Response regulator receiver domain; Region: Response_reg; pfam00072 483179002876 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483179002877 active site 483179002878 phosphorylation site [posttranslational modification] 483179002879 intermolecular recognition site; other site 483179002880 dimerization interface [polypeptide binding]; other site 483179002881 Predicted flavoproteins [General function prediction only]; Region: COG2081 483179002882 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 483179002883 Beta-lactamase; Region: Beta-lactamase; pfam00144 483179002884 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 483179002885 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 483179002886 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 483179002887 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 483179002888 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 483179002889 active site 483179002890 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 483179002891 TSCPD domain; Region: TSCPD; pfam12637 483179002892 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 483179002893 nudix motif; other site 483179002894 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 483179002895 active site 483179002896 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 483179002897 Ligand Binding Site [chemical binding]; other site 483179002898 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 483179002899 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 483179002900 putative MPT binding site; other site 483179002901 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 483179002902 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 483179002903 threonine dehydratase; Validated; Region: PRK08639 483179002904 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 483179002905 tetramer interface [polypeptide binding]; other site 483179002906 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483179002907 catalytic residue [active] 483179002908 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 483179002909 putative Ile/Val binding site [chemical binding]; other site 483179002910 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 483179002911 DEAD-like helicases superfamily; Region: DEXDc; smart00487 483179002912 ATP binding site [chemical binding]; other site 483179002913 Mg++ binding site [ion binding]; other site 483179002914 motif III; other site 483179002915 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 483179002916 nucleotide binding region [chemical binding]; other site 483179002917 ATP-binding site [chemical binding]; other site 483179002918 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 483179002919 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 483179002920 dimer interface [polypeptide binding]; other site 483179002921 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483179002922 catalytic residue [active] 483179002923 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 483179002924 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 483179002925 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 483179002926 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 483179002927 active site residue [active] 483179002928 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 483179002929 active site residue [active] 483179002930 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 483179002931 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 483179002932 Coenzyme A binding pocket [chemical binding]; other site 483179002933 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 483179002934 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 483179002935 metal binding site [ion binding]; metal-binding site 483179002936 active site 483179002937 I-site; other site 483179002938 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 483179002939 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 483179002940 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 483179002941 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 483179002942 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483179002943 putative substrate translocation pore; other site 483179002944 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 483179002945 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 483179002946 HlyD family secretion protein; Region: HlyD_3; pfam13437 483179002947 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 483179002948 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 483179002949 putative NAD(P) binding site [chemical binding]; other site 483179002950 putative substrate binding site [chemical binding]; other site 483179002951 catalytic Zn binding site [ion binding]; other site 483179002952 structural Zn binding site [ion binding]; other site 483179002953 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 483179002954 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 483179002955 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 483179002956 active site 483179002957 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 483179002958 Tetratricopeptide repeat; Region: TPR_1; pfam00515 483179002959 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483179002960 S-adenosylmethionine binding site [chemical binding]; other site 483179002961 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 483179002962 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 483179002963 UDP-glucose 4-epimerase; Region: PLN02240 483179002964 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 483179002965 NAD binding site [chemical binding]; other site 483179002966 homodimer interface [polypeptide binding]; other site 483179002967 active site 483179002968 substrate binding site [chemical binding]; other site 483179002969 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 483179002970 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 483179002971 homodimer interface [polypeptide binding]; other site 483179002972 metal binding site [ion binding]; metal-binding site 483179002973 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 483179002974 homodimer interface [polypeptide binding]; other site 483179002975 active site 483179002976 putative chemical substrate binding site [chemical binding]; other site 483179002977 metal binding site [ion binding]; metal-binding site 483179002978 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 483179002979 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 483179002980 putative FMN binding site [chemical binding]; other site 483179002981 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 483179002982 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 483179002983 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 483179002984 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 483179002985 active site 483179002986 dimer interface [polypeptide binding]; other site 483179002987 motif 1; other site 483179002988 motif 2; other site 483179002989 motif 3; other site 483179002990 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 483179002991 anticodon binding site; other site 483179002992 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 483179002993 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 483179002994 Sporulation related domain; Region: SPOR; pfam05036 483179002995 hypothetical protein; Validated; Region: PRK00041 483179002996 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 483179002997 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 483179002998 trimerization site [polypeptide binding]; other site 483179002999 active site 483179003000 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 483179003001 homodecamer interface [polypeptide binding]; other site 483179003002 GTP cyclohydrolase I; Provisional; Region: PLN03044 483179003003 active site 483179003004 putative catalytic site residues [active] 483179003005 zinc binding site [ion binding]; other site 483179003006 GTP-CH-I/GFRP interaction surface; other site 483179003007 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 483179003008 hypothetical protein; Provisional; Region: PRK10279 483179003009 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 483179003010 nucleophile elbow; other site 483179003011 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 483179003012 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 483179003013 active site 483179003014 DNA binding site [nucleotide binding] 483179003015 Int/Topo IB signature motif; other site 483179003016 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 483179003017 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 483179003018 catalytic residues [active] 483179003019 catalytic nucleophile [active] 483179003020 Presynaptic Site I dimer interface [polypeptide binding]; other site 483179003021 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 483179003022 Synaptic Flat tetramer interface [polypeptide binding]; other site 483179003023 Synaptic Site I dimer interface [polypeptide binding]; other site 483179003024 DNA binding site [nucleotide binding] 483179003025 BRO family, N-terminal domain; Region: Bro-N; cl10591 483179003026 Prophage antirepressor [Transcription]; Region: COG3617 483179003027 BRO family, N-terminal domain; Region: Bro-N; smart01040 483179003028 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 483179003029 CoA-transferase family III; Region: CoA_transf_3; pfam02515 483179003030 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 483179003031 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 483179003032 FAD binding site [chemical binding]; other site 483179003033 substrate binding pocket [chemical binding]; other site 483179003034 catalytic base [active] 483179003035 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 483179003036 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 483179003037 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 483179003038 dimerization interface [polypeptide binding]; other site 483179003039 substrate binding pocket [chemical binding]; other site 483179003040 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 483179003041 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 483179003042 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 483179003043 multidrug efflux protein; Reviewed; Region: PRK09579 483179003044 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 483179003045 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 483179003046 HlyD family secretion protein; Region: HlyD_3; pfam13437 483179003047 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 483179003048 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 483179003049 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 483179003050 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 483179003051 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 483179003052 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 483179003053 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 483179003054 active site 483179003055 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 483179003056 active site 483179003057 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 483179003058 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 483179003059 active site 483179003060 (T/H)XGH motif; other site 483179003061 DNA gyrase subunit A; Validated; Region: PRK05560 483179003062 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 483179003063 CAP-like domain; other site 483179003064 active site 483179003065 primary dimer interface [polypeptide binding]; other site 483179003066 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 483179003067 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 483179003068 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 483179003069 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 483179003070 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 483179003071 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 483179003072 Uncharacterized component of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3709 483179003073 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 483179003074 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 483179003075 DNA-binding site [nucleotide binding]; DNA binding site 483179003076 UTRA domain; Region: UTRA; pfam07702 483179003077 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 483179003078 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 483179003079 dimer interface [polypeptide binding]; other site 483179003080 ssDNA binding site [nucleotide binding]; other site 483179003081 tetramer (dimer of dimers) interface [polypeptide binding]; other site 483179003082 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 483179003083 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 483179003084 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 483179003085 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 483179003086 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 483179003087 IHF dimer interface [polypeptide binding]; other site 483179003088 IHF - DNA interface [nucleotide binding]; other site 483179003089 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 483179003090 Found in ATP-dependent protease La (LON); Region: LON; smart00464 483179003091 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483179003092 Walker A motif; other site 483179003093 ATP binding site [chemical binding]; other site 483179003094 Walker B motif; other site 483179003095 arginine finger; other site 483179003096 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 483179003097 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 483179003098 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 483179003099 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483179003100 Walker A motif; other site 483179003101 ATP binding site [chemical binding]; other site 483179003102 Walker B motif; other site 483179003103 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 483179003104 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 483179003105 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 483179003106 oligomer interface [polypeptide binding]; other site 483179003107 active site residues [active] 483179003108 GTPases [General function prediction only]; Region: HflX; COG2262 483179003109 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 483179003110 HflX GTPase family; Region: HflX; cd01878 483179003111 G1 box; other site 483179003112 GTP/Mg2+ binding site [chemical binding]; other site 483179003113 Switch I region; other site 483179003114 G2 box; other site 483179003115 G3 box; other site 483179003116 Switch II region; other site 483179003117 G4 box; other site 483179003118 G5 box; other site 483179003119 bacterial Hfq-like; Region: Hfq; cd01716 483179003120 hexamer interface [polypeptide binding]; other site 483179003121 Sm1 motif; other site 483179003122 RNA binding site [nucleotide binding]; other site 483179003123 Sm2 motif; other site 483179003124 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 483179003125 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 483179003126 TrkA-N domain; Region: TrkA_N; pfam02254 483179003127 TrkA-C domain; Region: TrkA_C; pfam02080 483179003128 TrkA-N domain; Region: TrkA_N; pfam02254 483179003129 TrkA-C domain; Region: TrkA_C; pfam02080 483179003130 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 483179003131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483179003132 active site 483179003133 phosphorylation site [posttranslational modification] 483179003134 intermolecular recognition site; other site 483179003135 dimerization interface [polypeptide binding]; other site 483179003136 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483179003137 Walker A motif; other site 483179003138 ATP binding site [chemical binding]; other site 483179003139 Walker B motif; other site 483179003140 arginine finger; other site 483179003141 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 483179003142 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 483179003143 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483179003144 dimerization interface [polypeptide binding]; other site 483179003145 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483179003146 dimer interface [polypeptide binding]; other site 483179003147 phosphorylation site [posttranslational modification] 483179003148 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483179003149 ATP binding site [chemical binding]; other site 483179003150 Mg2+ binding site [ion binding]; other site 483179003151 G-X-G motif; other site 483179003152 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 483179003153 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483179003154 active site 483179003155 phosphorylation site [posttranslational modification] 483179003156 intermolecular recognition site; other site 483179003157 dimerization interface [polypeptide binding]; other site 483179003158 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483179003159 Walker A motif; other site 483179003160 ATP binding site [chemical binding]; other site 483179003161 Walker B motif; other site 483179003162 arginine finger; other site 483179003163 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 483179003164 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 483179003165 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483179003166 dimer interface [polypeptide binding]; other site 483179003167 phosphorylation site [posttranslational modification] 483179003168 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483179003169 ATP binding site [chemical binding]; other site 483179003170 Mg2+ binding site [ion binding]; other site 483179003171 G-X-G motif; other site 483179003172 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 483179003173 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 483179003174 FMN binding site [chemical binding]; other site 483179003175 active site 483179003176 catalytic residues [active] 483179003177 substrate binding site [chemical binding]; other site 483179003178 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 483179003179 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 483179003180 substrate binding site; other site 483179003181 dimer interface; other site 483179003182 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 483179003183 homotrimer interaction site [polypeptide binding]; other site 483179003184 zinc binding site [ion binding]; other site 483179003185 CDP-binding sites; other site 483179003186 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 483179003187 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 483179003188 classical (c) SDRs; Region: SDR_c; cd05233 483179003189 NAD(P) binding site [chemical binding]; other site 483179003190 active site 483179003191 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 483179003192 putative coenzyme Q binding site [chemical binding]; other site 483179003193 lipoyl synthase; Provisional; Region: PRK05481 483179003194 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 483179003195 FeS/SAM binding site; other site 483179003196 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 483179003197 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 483179003198 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 483179003199 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 483179003200 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 483179003201 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 483179003202 E3 interaction surface; other site 483179003203 lipoyl attachment site [posttranslational modification]; other site 483179003204 e3 binding domain; Region: E3_binding; pfam02817 483179003205 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 483179003206 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 483179003207 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 483179003208 E3 interaction surface; other site 483179003209 lipoyl attachment site [posttranslational modification]; other site 483179003210 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 483179003211 alpha subunit interface [polypeptide binding]; other site 483179003212 TPP binding site [chemical binding]; other site 483179003213 heterodimer interface [polypeptide binding]; other site 483179003214 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 483179003215 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 483179003216 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 483179003217 tetramer interface [polypeptide binding]; other site 483179003218 TPP-binding site [chemical binding]; other site 483179003219 heterodimer interface [polypeptide binding]; other site 483179003220 phosphorylation loop region [posttranslational modification] 483179003221 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 483179003222 Septum formation initiator; Region: DivIC; pfam04977 483179003223 Methyltransferase domain; Region: Methyltransf_23; pfam13489 483179003224 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483179003225 S-adenosylmethionine binding site [chemical binding]; other site 483179003226 enolase; Provisional; Region: eno; PRK00077 483179003227 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 483179003228 dimer interface [polypeptide binding]; other site 483179003229 metal binding site [ion binding]; metal-binding site 483179003230 substrate binding pocket [chemical binding]; other site 483179003231 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 483179003232 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 483179003233 CTP synthetase; Validated; Region: pyrG; PRK05380 483179003234 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 483179003235 Catalytic site [active] 483179003236 active site 483179003237 UTP binding site [chemical binding]; other site 483179003238 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 483179003239 active site 483179003240 putative oxyanion hole; other site 483179003241 catalytic triad [active] 483179003242 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 483179003243 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 483179003244 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 483179003245 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 483179003246 triosephosphate isomerase; Provisional; Region: PRK14565 483179003247 substrate binding site [chemical binding]; other site 483179003248 dimer interface [polypeptide binding]; other site 483179003249 catalytic triad [active] 483179003250 SurA N-terminal domain; Region: SurA_N_3; cl07813 483179003251 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 483179003252 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 483179003253 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 483179003254 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 483179003255 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 483179003256 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 483179003257 active site 483179003258 ribulose/triose binding site [chemical binding]; other site 483179003259 phosphate binding site [ion binding]; other site 483179003260 substrate (anthranilate) binding pocket [chemical binding]; other site 483179003261 product (indole) binding pocket [chemical binding]; other site 483179003262 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 483179003263 trimer interface [polypeptide binding]; other site 483179003264 dimer interface [polypeptide binding]; other site 483179003265 putative active site [active] 483179003266 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 483179003267 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 483179003268 dimer interface [polypeptide binding]; other site 483179003269 putative functional site; other site 483179003270 putative MPT binding site; other site 483179003271 LexA repressor; Validated; Region: PRK00215 483179003272 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 483179003273 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 483179003274 Catalytic site [active] 483179003275 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 483179003276 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 483179003277 Competence protein; Region: Competence; pfam03772 483179003278 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 483179003279 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 483179003280 active site 483179003281 HIGH motif; other site 483179003282 nucleotide binding site [chemical binding]; other site 483179003283 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 483179003284 active site 483179003285 KMSKS motif; other site 483179003286 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 483179003287 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 483179003288 dimer interface [polypeptide binding]; other site 483179003289 active site 483179003290 citrylCoA binding site [chemical binding]; other site 483179003291 NADH binding [chemical binding]; other site 483179003292 cationic pore residues; other site 483179003293 oxalacetate/citrate binding site [chemical binding]; other site 483179003294 coenzyme A binding site [chemical binding]; other site 483179003295 catalytic triad [active] 483179003296 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 483179003297 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 483179003298 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3494 483179003299 Acyl-[acyl carrier protein]; Region: LpxA; COG1043 483179003300 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 483179003301 active site 483179003302 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 483179003303 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 483179003304 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 483179003305 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 483179003306 trimer interface [polypeptide binding]; other site 483179003307 active site 483179003308 UDP-GlcNAc binding site [chemical binding]; other site 483179003309 lipid binding site [chemical binding]; lipid-binding site 483179003310 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 483179003311 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 483179003312 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 483179003313 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 483179003314 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 483179003315 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 483179003316 Surface antigen; Region: Bac_surface_Ag; pfam01103 483179003317 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 483179003318 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 483179003319 active site 483179003320 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 483179003321 protein binding site [polypeptide binding]; other site 483179003322 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 483179003323 putative substrate binding region [chemical binding]; other site 483179003324 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 483179003325 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 483179003326 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834 483179003327 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 483179003328 catalytic residue [active] 483179003329 putative FPP diphosphate binding site; other site 483179003330 putative FPP binding hydrophobic cleft; other site 483179003331 dimer interface [polypeptide binding]; other site 483179003332 putative IPP diphosphate binding site; other site 483179003333 ribosome recycling factor; Reviewed; Region: frr; PRK00083 483179003334 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 483179003335 hinge region; other site 483179003336 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 483179003337 putative nucleotide binding site [chemical binding]; other site 483179003338 uridine monophosphate binding site [chemical binding]; other site 483179003339 homohexameric interface [polypeptide binding]; other site 483179003340 elongation factor Ts; Provisional; Region: tsf; PRK09377 483179003341 UBA/TS-N domain; Region: UBA; pfam00627 483179003342 Elongation factor TS; Region: EF_TS; pfam00889 483179003343 Elongation factor TS; Region: EF_TS; pfam00889 483179003344 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 483179003345 rRNA interaction site [nucleotide binding]; other site 483179003346 S8 interaction site; other site 483179003347 putative laminin-1 binding site; other site 483179003348 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 483179003349 Domain of unknown function (DUF1849); Region: DUF1849; pfam08904 483179003350 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 483179003351 homotrimer interaction site [polypeptide binding]; other site 483179003352 putative active site [active] 483179003353 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_3; cd08585 483179003354 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 483179003355 putative active site [active] 483179003356 catalytic site [active] 483179003357 putative metal binding site [ion binding]; other site 483179003358 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146 483179003359 Protein of unknown function, DUF482; Region: DUF482; pfam04339 483179003360 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 483179003361 HIT family signature motif; other site 483179003362 catalytic residue [active] 483179003363 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 483179003364 Clp amino terminal domain; Region: Clp_N; pfam02861 483179003365 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483179003366 Walker A motif; other site 483179003367 ATP binding site [chemical binding]; other site 483179003368 Walker B motif; other site 483179003369 arginine finger; other site 483179003370 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483179003371 Walker A motif; other site 483179003372 ATP binding site [chemical binding]; other site 483179003373 Walker B motif; other site 483179003374 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 483179003375 Uncharacterized conserved protein [Function unknown]; Region: COG2127 483179003376 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 483179003377 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 483179003378 Sporulation related domain; Region: SPOR; pfam05036 483179003379 Uncharacterized conserved protein [Function unknown]; Region: COG5458 483179003380 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 483179003381 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 483179003382 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 483179003383 Uncharacterized conserved protein [Function unknown]; Region: COG1434 483179003384 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 483179003385 putative active site [active] 483179003386 Predicted membrane protein [Function unknown]; Region: COG3503 483179003387 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 483179003388 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 483179003389 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 483179003390 DNA binding residues [nucleotide binding] 483179003391 putative dimer interface [polypeptide binding]; other site 483179003392 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 483179003393 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 483179003394 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3803 483179003395 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 483179003396 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 483179003397 non-specific DNA binding site [nucleotide binding]; other site 483179003398 salt bridge; other site 483179003399 sequence-specific DNA binding site [nucleotide binding]; other site 483179003400 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 483179003401 Domain of unknown function (DUF955); Region: DUF955; pfam06114 483179003402 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 483179003403 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 483179003404 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 483179003405 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 483179003406 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 483179003407 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 483179003408 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 483179003409 carboxyltransferase (CT) interaction site; other site 483179003410 biotinylation site [posttranslational modification]; other site 483179003411 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 483179003412 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 483179003413 active site 483179003414 substrate binding site [chemical binding]; other site 483179003415 coenzyme B12 binding site [chemical binding]; other site 483179003416 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 483179003417 B12 binding site [chemical binding]; other site 483179003418 cobalt ligand [ion binding]; other site 483179003419 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 483179003420 DctM-like transporters; Region: DctM; pfam06808 483179003421 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 483179003422 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 483179003423 glutamate racemase; Provisional; Region: PRK00865 483179003424 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 483179003425 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 483179003426 intracellular protease, PfpI family; Region: PfpI; TIGR01382 483179003427 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 483179003428 conserved cys residue [active] 483179003429 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 483179003430 isocitrate dehydrogenase; Validated; Region: PRK08299 483179003431 alkaline phosphatase; Provisional; Region: PRK10518 483179003432 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 483179003433 dimer interface [polypeptide binding]; other site 483179003434 active site 483179003435 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 483179003436 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 483179003437 motif 1; other site 483179003438 active site 483179003439 motif 2; other site 483179003440 motif 3; other site 483179003441 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 483179003442 recombinase A; Provisional; Region: recA; PRK09354 483179003443 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 483179003444 hexamer interface [polypeptide binding]; other site 483179003445 Walker A motif; other site 483179003446 ATP binding site [chemical binding]; other site 483179003447 Walker B motif; other site 483179003448 putative outer membrane lipoprotein; Provisional; Region: PRK10510 483179003449 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 483179003450 ligand binding site [chemical binding]; other site 483179003451 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 483179003452 N-acetyl-D-glucosamine binding site [chemical binding]; other site 483179003453 catalytic residue [active] 483179003454 recombination factor protein RarA; Reviewed; Region: PRK13342 483179003455 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483179003456 Walker A motif; other site 483179003457 ATP binding site [chemical binding]; other site 483179003458 Walker B motif; other site 483179003459 arginine finger; other site 483179003460 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 483179003461 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 483179003462 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 483179003463 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 483179003464 protein binding site [polypeptide binding]; other site 483179003465 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 483179003466 protein binding site [polypeptide binding]; other site 483179003467 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 483179003468 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 483179003469 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 483179003470 alphaNTD homodimer interface [polypeptide binding]; other site 483179003471 alphaNTD - beta interaction site [polypeptide binding]; other site 483179003472 alphaNTD - beta' interaction site [polypeptide binding]; other site 483179003473 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 483179003474 30S ribosomal protein S11; Validated; Region: PRK05309 483179003475 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 483179003476 30S ribosomal protein S13; Region: bact_S13; TIGR03631 483179003477 adenylate kinase; Reviewed; Region: adk; PRK00279 483179003478 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 483179003479 AMP-binding site [chemical binding]; other site 483179003480 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 483179003481 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 483179003482 SecY translocase; Region: SecY; pfam00344 483179003483 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 483179003484 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 483179003485 23S rRNA binding site [nucleotide binding]; other site 483179003486 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 483179003487 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 483179003488 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 483179003489 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 483179003490 5S rRNA interface [nucleotide binding]; other site 483179003491 23S rRNA interface [nucleotide binding]; other site 483179003492 L5 interface [polypeptide binding]; other site 483179003493 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 483179003494 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 483179003495 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 483179003496 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 483179003497 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 483179003498 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 483179003499 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 483179003500 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 483179003501 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 483179003502 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 483179003503 RNA binding site [nucleotide binding]; other site 483179003504 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 483179003505 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 483179003506 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 483179003507 23S rRNA interface [nucleotide binding]; other site 483179003508 putative translocon interaction site; other site 483179003509 signal recognition particle (SRP54) interaction site; other site 483179003510 L23 interface [polypeptide binding]; other site 483179003511 trigger factor interaction site; other site 483179003512 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 483179003513 23S rRNA interface [nucleotide binding]; other site 483179003514 5S rRNA interface [nucleotide binding]; other site 483179003515 putative antibiotic binding site [chemical binding]; other site 483179003516 L25 interface [polypeptide binding]; other site 483179003517 L27 interface [polypeptide binding]; other site 483179003518 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 483179003519 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 483179003520 G-X-X-G motif; other site 483179003521 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 483179003522 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 483179003523 putative translocon binding site; other site 483179003524 protein-rRNA interface [nucleotide binding]; other site 483179003525 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 483179003526 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 483179003527 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 483179003528 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 483179003529 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 483179003530 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 483179003531 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 483179003532 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 483179003533 elongation factor Tu; Reviewed; Region: PRK00049 483179003534 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 483179003535 G1 box; other site 483179003536 GEF interaction site [polypeptide binding]; other site 483179003537 GTP/Mg2+ binding site [chemical binding]; other site 483179003538 Switch I region; other site 483179003539 G2 box; other site 483179003540 G3 box; other site 483179003541 Switch II region; other site 483179003542 G4 box; other site 483179003543 G5 box; other site 483179003544 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 483179003545 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 483179003546 Antibiotic Binding Site [chemical binding]; other site 483179003547 elongation factor G; Reviewed; Region: PRK00007 483179003548 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 483179003549 G1 box; other site 483179003550 putative GEF interaction site [polypeptide binding]; other site 483179003551 GTP/Mg2+ binding site [chemical binding]; other site 483179003552 Switch I region; other site 483179003553 G2 box; other site 483179003554 G3 box; other site 483179003555 Switch II region; other site 483179003556 G4 box; other site 483179003557 G5 box; other site 483179003558 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 483179003559 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 483179003560 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 483179003561 30S ribosomal protein S7; Validated; Region: PRK05302 483179003562 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 483179003563 S17 interaction site [polypeptide binding]; other site 483179003564 S8 interaction site; other site 483179003565 16S rRNA interaction site [nucleotide binding]; other site 483179003566 streptomycin interaction site [chemical binding]; other site 483179003567 23S rRNA interaction site [nucleotide binding]; other site 483179003568 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 483179003569 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 483179003570 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 483179003571 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 483179003572 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 483179003573 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 483179003574 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 483179003575 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 483179003576 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 483179003577 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 483179003578 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 483179003579 DNA binding site [nucleotide binding] 483179003580 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 483179003581 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 483179003582 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 483179003583 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 483179003584 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 483179003585 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 483179003586 RPB11 interaction site [polypeptide binding]; other site 483179003587 RPB12 interaction site [polypeptide binding]; other site 483179003588 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 483179003589 RPB1 interaction site [polypeptide binding]; other site 483179003590 RPB11 interaction site [polypeptide binding]; other site 483179003591 RPB10 interaction site [polypeptide binding]; other site 483179003592 RPB3 interaction site [polypeptide binding]; other site 483179003593 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 483179003594 L11 interface [polypeptide binding]; other site 483179003595 putative EF-Tu interaction site [polypeptide binding]; other site 483179003596 putative EF-G interaction site [polypeptide binding]; other site 483179003597 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 483179003598 23S rRNA interface [nucleotide binding]; other site 483179003599 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 483179003600 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 483179003601 mRNA/rRNA interface [nucleotide binding]; other site 483179003602 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 483179003603 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 483179003604 23S rRNA interface [nucleotide binding]; other site 483179003605 L7/L12 interface [polypeptide binding]; other site 483179003606 putative thiostrepton binding site; other site 483179003607 L25 interface [polypeptide binding]; other site 483179003608 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 483179003609 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 483179003610 putative homodimer interface [polypeptide binding]; other site 483179003611 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 483179003612 heterodimer interface [polypeptide binding]; other site 483179003613 homodimer interface [polypeptide binding]; other site 483179003614 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 483179003615 elongation factor Tu; Reviewed; Region: PRK00049 483179003616 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 483179003617 G1 box; other site 483179003618 GEF interaction site [polypeptide binding]; other site 483179003619 GTP/Mg2+ binding site [chemical binding]; other site 483179003620 Switch I region; other site 483179003621 G2 box; other site 483179003622 G3 box; other site 483179003623 Switch II region; other site 483179003624 G4 box; other site 483179003625 G5 box; other site 483179003626 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 483179003627 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 483179003628 Antibiotic Binding Site [chemical binding]; other site 483179003629 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 483179003630 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 483179003631 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 483179003632 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 483179003633 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 483179003634 PAS domain; Region: PAS_5; pfam07310 483179003635 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 483179003636 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 483179003637 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 483179003638 trimer interface [polypeptide binding]; other site 483179003639 putative metal binding site [ion binding]; other site 483179003640 Protein of unknown function (DUF3126); Region: DUF3126; pfam11324 483179003641 serine acetyltransferase; Provisional; Region: cysE; PRK11132 483179003642 Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971 483179003643 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 483179003644 trimer interface [polypeptide binding]; other site 483179003645 active site 483179003646 substrate binding site [chemical binding]; other site 483179003647 CoA binding site [chemical binding]; other site 483179003648 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 483179003649 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 483179003650 Uncharacterized conserved protein [Function unknown]; Region: COG1430 483179003651 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 483179003652 DNA-binding site [nucleotide binding]; DNA binding site 483179003653 RNA-binding motif; other site 483179003654 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 483179003655 DNA-binding site [nucleotide binding]; DNA binding site 483179003656 RNA-binding motif; other site 483179003657 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 483179003658 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 483179003659 dimer interface [polypeptide binding]; other site 483179003660 active site 483179003661 metal binding site [ion binding]; metal-binding site 483179003662 glutathione binding site [chemical binding]; other site 483179003663 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 483179003664 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 483179003665 DHH family; Region: DHH; pfam01368 483179003666 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 483179003667 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 483179003668 ATP-grasp domain; Region: ATP-grasp_4; cl17255 483179003669 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 483179003670 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 483179003671 putative active site [active] 483179003672 homoserine dehydrogenase; Provisional; Region: PRK06349 483179003673 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 483179003674 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 483179003675 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 483179003676 aminotransferase; Validated; Region: PRK09148 483179003677 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 483179003678 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483179003679 homodimer interface [polypeptide binding]; other site 483179003680 catalytic residue [active] 483179003681 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 483179003682 Peptidase M15; Region: Peptidase_M15_3; cl01194 483179003683 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3553 483179003684 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 483179003685 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 483179003686 active site 483179003687 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 483179003688 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 483179003689 MPN+ (JAMM) motif; other site 483179003690 Zinc-binding site [ion binding]; other site 483179003691 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 483179003692 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 483179003693 active site 483179003694 SAM binding site [chemical binding]; other site 483179003695 putative homodimer interface [polypeptide binding]; other site 483179003696 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 483179003697 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483179003698 S-adenosylmethionine binding site [chemical binding]; other site 483179003699 precorrin-3B synthase; Region: CobG; TIGR02435 483179003700 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 483179003701 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 483179003702 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 483179003703 Precorrin-8X methylmutase; Region: CbiC; pfam02570 483179003704 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 483179003705 active site 483179003706 SAM binding site [chemical binding]; other site 483179003707 homodimer interface [polypeptide binding]; other site 483179003708 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 483179003709 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 483179003710 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 483179003711 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 483179003712 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 483179003713 active site 483179003714 SAM binding site [chemical binding]; other site 483179003715 homodimer interface [polypeptide binding]; other site 483179003716 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 483179003717 Flavin Reductases; Region: FlaRed; cl00801 483179003718 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 483179003719 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 483179003720 ligand binding site [chemical binding]; other site 483179003721 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 483179003722 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 483179003723 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 483179003724 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 483179003725 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483179003726 homodimer interface [polypeptide binding]; other site 483179003727 catalytic residue [active] 483179003728 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 483179003729 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 483179003730 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 483179003731 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 483179003732 active site 483179003733 SAM binding site [chemical binding]; other site 483179003734 homodimer interface [polypeptide binding]; other site 483179003735 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 483179003736 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 483179003737 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 483179003738 active site 483179003739 SAM binding site [chemical binding]; other site 483179003740 homodimer interface [polypeptide binding]; other site 483179003741 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 483179003742 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 483179003743 tellurium resistance terB-like protein; Region: terB_like; cd07177 483179003744 metal binding site [ion binding]; metal-binding site 483179003745 hypothetical protein; Provisional; Region: PRK10621 483179003746 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 483179003747 Predicted membrane protein [Function unknown]; Region: COG2510 483179003748 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 483179003749 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 483179003750 homodimer interface [polypeptide binding]; other site 483179003751 Walker A motif; other site 483179003752 ATP binding site [chemical binding]; other site 483179003753 hydroxycobalamin binding site [chemical binding]; other site 483179003754 Walker B motif; other site 483179003755 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 483179003756 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 483179003757 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 483179003758 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 483179003759 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 483179003760 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 483179003761 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 483179003762 homotrimer interface [polypeptide binding]; other site 483179003763 Walker A motif; other site 483179003764 GTP binding site [chemical binding]; other site 483179003765 Walker B motif; other site 483179003766 Predicted integral membrane protein [Function unknown]; Region: COG5446 483179003767 cobalt transporter subunit CbtB (proposed); Region: CbtB; TIGR02459 483179003768 cobyric acid synthase; Provisional; Region: PRK00784 483179003769 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 483179003770 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 483179003771 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 483179003772 catalytic triad [active] 483179003773 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 483179003774 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 483179003775 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 483179003776 Predicted small secreted protein [Function unknown]; Region: COG5510 483179003777 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 483179003778 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 483179003779 conserved cys residue [active] 483179003780 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 483179003781 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 483179003782 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 483179003783 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 483179003784 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 483179003785 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 483179003786 Protein export membrane protein; Region: SecD_SecF; pfam02355 483179003787 putative cation:proton antiport protein; Provisional; Region: PRK10669 483179003788 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 483179003789 TrkA-N domain; Region: TrkA_N; pfam02254 483179003790 Predicted integral membrane protein [Function unknown]; Region: COG0392 483179003791 Serine hydrolase; Region: Ser_hydrolase; pfam06821 483179003792 sulfate transport protein; Provisional; Region: cysT; CHL00187 483179003793 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179003794 dimer interface [polypeptide binding]; other site 483179003795 conserved gate region; other site 483179003796 putative PBP binding loops; other site 483179003797 ABC-ATPase subunit interface; other site 483179003798 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 483179003799 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179003800 dimer interface [polypeptide binding]; other site 483179003801 conserved gate region; other site 483179003802 putative PBP binding loops; other site 483179003803 ABC-ATPase subunit interface; other site 483179003804 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CysP; COG4150 483179003805 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 483179003806 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 483179003807 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 483179003808 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 483179003809 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 483179003810 Transporter associated domain; Region: CorC_HlyC; smart01091 483179003811 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 483179003812 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 483179003813 EF-hand domain pair; Region: EF_hand_5; pfam13499 483179003814 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 483179003815 Ca2+ binding site [ion binding]; other site 483179003816 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 483179003817 Ca2+ binding site [ion binding]; other site 483179003818 Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154 483179003819 short chain dehydrogenase; Provisional; Region: PRK06198 483179003820 classical (c) SDRs; Region: SDR_c; cd05233 483179003821 NAD(P) binding site [chemical binding]; other site 483179003822 active site 483179003823 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 483179003824 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 483179003825 Walker A/P-loop; other site 483179003826 ATP binding site [chemical binding]; other site 483179003827 Q-loop/lid; other site 483179003828 ABC transporter signature motif; other site 483179003829 Walker B; other site 483179003830 D-loop; other site 483179003831 H-loop/switch region; other site 483179003832 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 483179003833 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 483179003834 TM-ABC transporter signature motif; other site 483179003835 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 483179003836 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 483179003837 putative ligand binding site [chemical binding]; other site 483179003838 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 483179003839 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 483179003840 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 483179003841 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 483179003842 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 483179003843 Walker A/P-loop; other site 483179003844 ATP binding site [chemical binding]; other site 483179003845 Q-loop/lid; other site 483179003846 ABC transporter signature motif; other site 483179003847 Walker B; other site 483179003848 D-loop; other site 483179003849 H-loop/switch region; other site 483179003850 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 483179003851 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 483179003852 ABC-ATPase subunit interface; other site 483179003853 dimer interface [polypeptide binding]; other site 483179003854 putative PBP binding regions; other site 483179003855 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 483179003856 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 483179003857 intersubunit interface [polypeptide binding]; other site 483179003858 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 483179003859 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 483179003860 N-terminal plug; other site 483179003861 ligand-binding site [chemical binding]; other site 483179003862 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 483179003863 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 483179003864 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 483179003865 HlyD family secretion protein; Region: HlyD_3; pfam13437 483179003866 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 483179003867 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 483179003868 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 483179003869 alpha-gamma subunit interface [polypeptide binding]; other site 483179003870 beta-gamma subunit interface [polypeptide binding]; other site 483179003871 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 483179003872 alpha-beta subunit interface [polypeptide binding]; other site 483179003873 urease subunit alpha; Reviewed; Region: ureC; PRK13309 483179003874 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 483179003875 subunit interactions [polypeptide binding]; other site 483179003876 active site 483179003877 flap region; other site 483179003878 urease accessory protein UreE; Provisional; Region: ureE; PRK14711 483179003879 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 483179003880 dimer interface [polypeptide binding]; other site 483179003881 catalytic residues [active] 483179003882 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 483179003883 UreF; Region: UreF; pfam01730 483179003884 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 483179003885 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 483179003886 Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413 483179003887 ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266 483179003888 cobalt transport protein CbiM; Validated; Region: PRK06265 483179003889 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 483179003890 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 483179003891 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 483179003892 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 483179003893 Walker A/P-loop; other site 483179003894 ATP binding site [chemical binding]; other site 483179003895 Q-loop/lid; other site 483179003896 ABC transporter signature motif; other site 483179003897 Walker B; other site 483179003898 D-loop; other site 483179003899 H-loop/switch region; other site 483179003900 camphor resistance protein CrcB; Provisional; Region: ccrB; PRK01636 483179003901 Uncharacterized conserved protein [Function unknown]; Region: COG3439 483179003902 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 483179003903 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 483179003904 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 483179003905 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 483179003906 nudix motif; other site 483179003907 BA14K-like protein; Region: BA14K; pfam07886 483179003908 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 483179003909 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 483179003910 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483179003911 homodimer interface [polypeptide binding]; other site 483179003912 catalytic residue [active] 483179003913 ketol-acid reductoisomerase; Provisional; Region: PRK05479 483179003914 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 483179003915 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 483179003916 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 483179003917 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 483179003918 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 483179003919 potassium uptake protein; Region: kup; TIGR00794 483179003920 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cl00541 483179003921 active site 483179003922 hydrophilic channel; other site 483179003923 dimerization interface [polypeptide binding]; other site 483179003924 catalytic residues [active] 483179003925 active site lid [active] 483179003926 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 483179003927 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 483179003928 AAA domain; Region: AAA_30; pfam13604 483179003929 Family description; Region: UvrD_C_2; pfam13538 483179003930 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 483179003931 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 483179003932 putative valine binding site [chemical binding]; other site 483179003933 dimer interface [polypeptide binding]; other site 483179003934 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 483179003935 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 483179003936 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 483179003937 PYR/PP interface [polypeptide binding]; other site 483179003938 dimer interface [polypeptide binding]; other site 483179003939 TPP binding site [chemical binding]; other site 483179003940 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 483179003941 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 483179003942 TPP-binding site [chemical binding]; other site 483179003943 dimer interface [polypeptide binding]; other site 483179003944 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 483179003945 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 483179003946 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 483179003947 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 483179003948 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 483179003949 motif II; other site 483179003950 Predicted flavoproteins [General function prediction only]; Region: COG2081 483179003951 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 483179003952 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 483179003953 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 483179003954 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 483179003955 protein binding site [polypeptide binding]; other site 483179003956 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 483179003957 protein binding site [polypeptide binding]; other site 483179003958 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 483179003959 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 483179003960 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 483179003961 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 483179003962 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 483179003963 HflK protein; Region: hflK; TIGR01933 483179003964 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 483179003965 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 483179003966 folate binding site [chemical binding]; other site 483179003967 NADP+ binding site [chemical binding]; other site 483179003968 thymidylate synthase; Reviewed; Region: thyA; PRK01827 483179003969 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 483179003970 dimerization interface [polypeptide binding]; other site 483179003971 active site 483179003972 Protein of unknown function (DUF2853); Region: DUF2853; pfam11015 483179003973 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483179003974 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 483179003975 putative substrate translocation pore; other site 483179003976 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 483179003977 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 483179003978 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 483179003979 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814 483179003980 Domain of unknown function (DUF4169); Region: DUF4169; pfam13770 483179003981 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 483179003982 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 483179003983 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 483179003984 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 483179003985 FAD binding domain; Region: FAD_binding_4; pfam01565 483179003986 Uncharacterized conserved protein [Function unknown]; Region: COG4702 483179003987 serine/threonine protein kinase; Provisional; Region: PRK09188 483179003988 serine/threonine protein kinase; Provisional; Region: PRK12274 483179003989 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 483179003990 Part of AAA domain; Region: AAA_19; pfam13245 483179003991 Family description; Region: UvrD_C_2; pfam13538 483179003992 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 483179003993 CreA protein; Region: CreA; pfam05981 483179003994 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 483179003995 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 483179003996 trimer interface [polypeptide binding]; other site 483179003997 active site 483179003998 substrate binding site [chemical binding]; other site 483179003999 CoA binding site [chemical binding]; other site 483179004000 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 483179004001 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 483179004002 Cu(I) binding site [ion binding]; other site 483179004003 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 483179004004 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483179004005 S-adenosylmethionine binding site [chemical binding]; other site 483179004006 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 483179004007 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 483179004008 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 483179004009 active site 483179004010 Uncharacterized conserved protein [Function unknown]; Region: COG5587 483179004011 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 483179004012 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 483179004013 nucleotide binding pocket [chemical binding]; other site 483179004014 K-X-D-G motif; other site 483179004015 catalytic site [active] 483179004016 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 483179004017 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 483179004018 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 483179004019 Dimer interface [polypeptide binding]; other site 483179004020 BRCT sequence motif; other site 483179004021 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 483179004022 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 483179004023 Walker A/P-loop; other site 483179004024 ATP binding site [chemical binding]; other site 483179004025 Q-loop/lid; other site 483179004026 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 483179004027 ABC transporter signature motif; other site 483179004028 Walker B; other site 483179004029 D-loop; other site 483179004030 H-loop/switch region; other site 483179004031 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 483179004032 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 483179004033 binding surface 483179004034 TPR motif; other site 483179004035 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 483179004036 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 483179004037 cell division protein FtsZ; Validated; Region: PRK09330 483179004038 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 483179004039 nucleotide binding site [chemical binding]; other site 483179004040 SulA interaction site; other site 483179004041 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 483179004042 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 483179004043 Cell division protein FtsA; Region: FtsA; smart00842 483179004044 Cell division protein FtsA; Region: FtsA; pfam14450 483179004045 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 483179004046 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 483179004047 Cell division protein FtsQ; Region: FtsQ; pfam03799 483179004048 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 483179004049 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 483179004050 ATP-grasp domain; Region: ATP-grasp_4; cl17255 483179004051 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 483179004052 FAD binding domain; Region: FAD_binding_4; pfam01565 483179004053 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 483179004054 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 483179004055 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 483179004056 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 483179004057 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 483179004058 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 483179004059 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 483179004060 active site 483179004061 homodimer interface [polypeptide binding]; other site 483179004062 cell division protein FtsW; Region: ftsW; TIGR02614 483179004063 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 483179004064 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 483179004065 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 483179004066 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 483179004067 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 483179004068 Mg++ binding site [ion binding]; other site 483179004069 putative catalytic motif [active] 483179004070 putative substrate binding site [chemical binding]; other site 483179004071 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093 483179004072 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 483179004073 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 483179004074 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 483179004075 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 483179004076 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 483179004077 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 483179004078 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 483179004079 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 483179004080 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 483179004081 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 483179004082 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 483179004083 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 483179004084 MraW methylase family; Region: Methyltransf_5; cl17771 483179004085 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 483179004086 manganese transport protein MntH; Reviewed; Region: PRK00701 483179004087 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 483179004088 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 483179004089 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 483179004090 N-acetyl-D-glucosamine binding site [chemical binding]; other site 483179004091 catalytic residue [active] 483179004092 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 483179004093 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 483179004094 amidase catalytic site [active] 483179004095 Zn binding residues [ion binding]; other site 483179004096 substrate binding site [chemical binding]; other site 483179004097 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 483179004098 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 483179004099 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 483179004100 putative metal binding site [ion binding]; other site 483179004101 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 483179004102 HSP70 interaction site [polypeptide binding]; other site 483179004103 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 483179004104 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 483179004105 active site 483179004106 Predicted permeases [General function prediction only]; Region: COG0679 483179004107 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 483179004108 FAD binding site [chemical binding]; other site 483179004109 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 483179004110 dimerization interface [polypeptide binding]; other site 483179004111 putative DNA binding site [nucleotide binding]; other site 483179004112 putative Zn2+ binding site [ion binding]; other site 483179004113 Methyltransferase domain; Region: Methyltransf_23; pfam13489 483179004114 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483179004115 S-adenosylmethionine binding site [chemical binding]; other site 483179004116 Uncharacterized conserved protein [Function unknown]; Region: COG5586 483179004117 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 483179004118 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483179004119 putative substrate translocation pore; other site 483179004120 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 483179004121 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483179004122 S-adenosylmethionine binding site [chemical binding]; other site 483179004123 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 483179004124 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483179004125 Walker A/P-loop; other site 483179004126 ATP binding site [chemical binding]; other site 483179004127 Q-loop/lid; other site 483179004128 ABC transporter signature motif; other site 483179004129 Walker B; other site 483179004130 D-loop; other site 483179004131 H-loop/switch region; other site 483179004132 ABC transporter; Region: ABC_tran_2; pfam12848 483179004133 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 483179004134 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 483179004135 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 483179004136 PGAP1-like protein; Region: PGAP1; pfam07819 483179004137 Protein of unknown function (DUF1498); Region: DUF1498; pfam07385 483179004138 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 483179004139 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 483179004140 [2Fe-2S] cluster binding site [ion binding]; other site 483179004141 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 483179004142 putative alpha subunit interface [polypeptide binding]; other site 483179004143 putative active site [active] 483179004144 putative substrate binding site [chemical binding]; other site 483179004145 Fe binding site [ion binding]; other site 483179004146 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 483179004147 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 483179004148 FAD binding pocket [chemical binding]; other site 483179004149 FAD binding motif [chemical binding]; other site 483179004150 phosphate binding motif [ion binding]; other site 483179004151 beta-alpha-beta structure motif; other site 483179004152 NAD binding pocket [chemical binding]; other site 483179004153 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 483179004154 catalytic loop [active] 483179004155 iron binding site [ion binding]; other site 483179004156 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 483179004157 PhnA protein; Region: PhnA; pfam03831 483179004158 Isochorismatase family; Region: Isochorismatase; pfam00857 483179004159 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 483179004160 catalytic triad [active] 483179004161 metal binding site [ion binding]; metal-binding site 483179004162 conserved cis-peptide bond; other site 483179004163 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899 483179004164 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 483179004165 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 483179004166 active site 483179004167 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 483179004168 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 483179004169 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 483179004170 active site 483179004171 catalytic residues [active] 483179004172 DNA binding site [nucleotide binding] 483179004173 Int/Topo IB signature motif; other site 483179004174 Uncharacterized conserved protein [Function unknown]; Region: COG2968 483179004175 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 483179004176 hypothetical protein; Provisional; Region: PRK05170 483179004177 Uncharacterized conserved protein [Function unknown]; Region: COG5453 483179004178 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 483179004179 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 483179004180 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 483179004181 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 483179004182 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 483179004183 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 483179004184 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 483179004185 DNA binding residues [nucleotide binding] 483179004186 DNA primase; Validated; Region: dnaG; PRK05667 483179004187 CHC2 zinc finger; Region: zf-CHC2; pfam01807 483179004188 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 483179004189 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 483179004190 active site 483179004191 metal binding site [ion binding]; metal-binding site 483179004192 interdomain interaction site; other site 483179004193 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 483179004194 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 483179004195 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 483179004196 PhoU domain; Region: PhoU; pfam01895 483179004197 PhoU domain; Region: PhoU; pfam01895 483179004198 Uncharacterized conserved protein [Function unknown]; Region: COG1610 483179004199 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 483179004200 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 483179004201 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 483179004202 catalytic site [active] 483179004203 subunit interface [polypeptide binding]; other site 483179004204 Predicted metalloprotease [General function prediction only]; Region: COG2321 483179004205 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 483179004206 Predicted membrane protein [Function unknown]; Region: COG5395 483179004207 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 483179004208 LytTr DNA-binding domain; Region: LytTR; pfam04397 483179004209 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 483179004210 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 483179004211 ATP-grasp domain; Region: ATP-grasp_4; cl17255 483179004212 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 483179004213 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 483179004214 ATP-grasp domain; Region: ATP-grasp_4; cl17255 483179004215 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 483179004216 IMP binding site; other site 483179004217 dimer interface [polypeptide binding]; other site 483179004218 partial ornithine binding site; other site 483179004219 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 483179004220 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 483179004221 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 483179004222 NUDIX domain; Region: NUDIX; pfam00293 483179004223 nudix motif; other site 483179004224 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 483179004225 DNA-binding site [nucleotide binding]; DNA binding site 483179004226 RNA-binding motif; other site 483179004227 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 483179004228 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 483179004229 putative C-terminal domain interface [polypeptide binding]; other site 483179004230 putative GSH binding site (G-site) [chemical binding]; other site 483179004231 putative dimer interface [polypeptide binding]; other site 483179004232 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 483179004233 N-terminal domain interface [polypeptide binding]; other site 483179004234 dimer interface [polypeptide binding]; other site 483179004235 substrate binding pocket (H-site) [chemical binding]; other site 483179004236 aspartate aminotransferase; Provisional; Region: PRK05764 483179004237 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 483179004238 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483179004239 homodimer interface [polypeptide binding]; other site 483179004240 catalytic residue [active] 483179004241 Transcriptional regulator [Transcription]; Region: LysR; COG0583 483179004242 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 483179004243 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 483179004244 putative effector binding pocket; other site 483179004245 dimerization interface [polypeptide binding]; other site 483179004246 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 483179004247 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 483179004248 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 483179004249 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 483179004250 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 483179004251 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 483179004252 putative DNA binding site [nucleotide binding]; other site 483179004253 putative Zn2+ binding site [ion binding]; other site 483179004254 AsnC family; Region: AsnC_trans_reg; pfam01037 483179004255 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 483179004256 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 483179004257 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 483179004258 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 483179004259 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 483179004260 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 483179004261 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 483179004262 EamA-like transporter family; Region: EamA; pfam00892 483179004263 EamA-like transporter family; Region: EamA; pfam00892 483179004264 Protein of unknown function, DUF486; Region: DUF486; cl01236 483179004265 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921 483179004266 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 483179004267 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 483179004268 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 483179004269 Bacterial SH3 domain; Region: SH3_3; pfam08239 483179004270 excinuclease ABC subunit B; Provisional; Region: PRK05298 483179004271 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 483179004272 ATP binding site [chemical binding]; other site 483179004273 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 483179004274 nucleotide binding region [chemical binding]; other site 483179004275 ATP-binding site [chemical binding]; other site 483179004276 Ultra-violet resistance protein B; Region: UvrB; pfam12344 483179004277 UvrB/uvrC motif; Region: UVR; pfam02151 483179004278 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 483179004279 DNA-binding site [nucleotide binding]; DNA binding site 483179004280 RNA-binding motif; other site 483179004281 BA14K-like protein; Region: BA14K; pfam07886 483179004282 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 483179004283 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 483179004284 MarR family; Region: MarR_2; pfam12802 483179004285 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 483179004286 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483179004287 active site 483179004288 phosphorylation site [posttranslational modification] 483179004289 intermolecular recognition site; other site 483179004290 dimerization interface [polypeptide binding]; other site 483179004291 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 483179004292 DNA binding site [nucleotide binding] 483179004293 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 483179004294 dimer interface [polypeptide binding]; other site 483179004295 phosphorylation site [posttranslational modification] 483179004296 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483179004297 ATP binding site [chemical binding]; other site 483179004298 Mg2+ binding site [ion binding]; other site 483179004299 G-X-G motif; other site 483179004300 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 483179004301 dimer interface [polypeptide binding]; other site 483179004302 putative tRNA-binding site [nucleotide binding]; other site 483179004303 Uncharacterized conserved protein [Function unknown]; Region: COG5465 483179004304 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 483179004305 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 483179004306 Uncharacterized conserved protein [Function unknown]; Region: COG1565 483179004307 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 483179004308 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 483179004309 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 483179004310 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 483179004311 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 483179004312 active site 483179004313 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 483179004314 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 483179004315 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 483179004316 active site 483179004317 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 483179004318 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 483179004319 5S rRNA interface [nucleotide binding]; other site 483179004320 CTC domain interface [polypeptide binding]; other site 483179004321 L16 interface [polypeptide binding]; other site 483179004322 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 483179004323 putative active site [active] 483179004324 catalytic residue [active] 483179004325 GTP-binding protein YchF; Reviewed; Region: PRK09601 483179004326 YchF GTPase; Region: YchF; cd01900 483179004327 G1 box; other site 483179004328 GTP/Mg2+ binding site [chemical binding]; other site 483179004329 Switch I region; other site 483179004330 G2 box; other site 483179004331 Switch II region; other site 483179004332 G3 box; other site 483179004333 G4 box; other site 483179004334 G5 box; other site 483179004335 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 483179004336 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 483179004337 putative active site [active] 483179004338 putative catalytic site [active] 483179004339 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 483179004340 putative active site [active] 483179004341 putative catalytic site [active] 483179004342 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 483179004343 active site 483179004344 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 483179004345 cytochrome b; Provisional; Region: CYTB; MTH00191 483179004346 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 483179004347 Qi binding site; other site 483179004348 intrachain domain interface; other site 483179004349 interchain domain interface [polypeptide binding]; other site 483179004350 heme bH binding site [chemical binding]; other site 483179004351 heme bL binding site [chemical binding]; other site 483179004352 Qo binding site; other site 483179004353 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 483179004354 interchain domain interface [polypeptide binding]; other site 483179004355 intrachain domain interface; other site 483179004356 Qi binding site; other site 483179004357 Qo binding site; other site 483179004358 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 483179004359 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 483179004360 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 483179004361 [2Fe-2S] cluster binding site [ion binding]; other site 483179004362 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 483179004363 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 483179004364 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483179004365 Walker A/P-loop; other site 483179004366 ATP binding site [chemical binding]; other site 483179004367 Q-loop/lid; other site 483179004368 ABC transporter signature motif; other site 483179004369 Walker B; other site 483179004370 D-loop; other site 483179004371 H-loop/switch region; other site 483179004372 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 483179004373 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 483179004374 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 483179004375 Walker A/P-loop; other site 483179004376 ATP binding site [chemical binding]; other site 483179004377 Q-loop/lid; other site 483179004378 ABC transporter signature motif; other site 483179004379 Walker B; other site 483179004380 D-loop; other site 483179004381 H-loop/switch region; other site 483179004382 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 483179004383 Purine nucleoside permease [Nucleotide transport and metabolism]; Region: NUP; COG5042 483179004384 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 483179004385 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752 483179004386 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 483179004387 Coenzyme A binding pocket [chemical binding]; other site 483179004388 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 483179004389 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 483179004390 active site 483179004391 NTP binding site [chemical binding]; other site 483179004392 metal binding triad [ion binding]; metal-binding site 483179004393 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 483179004394 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 483179004395 putative active site [active] 483179004396 putative CoA binding site [chemical binding]; other site 483179004397 nudix motif; other site 483179004398 metal binding site [ion binding]; metal-binding site 483179004399 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816 483179004400 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 483179004401 MoxR-like ATPases [General function prediction only]; Region: COG0714 483179004402 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 483179004403 ATP binding site [chemical binding]; other site 483179004404 Walker B motif; other site 483179004405 arginine finger; other site 483179004406 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 483179004407 Protein of unknown function DUF58; Region: DUF58; pfam01882 483179004408 N-terminal double-transmembrane domain; Region: two_anch; TIGR02226 483179004409 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 483179004410 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 483179004411 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 483179004412 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 483179004413 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 483179004414 Coenzyme A binding pocket [chemical binding]; other site 483179004415 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 483179004416 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 483179004417 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 483179004418 putative dimer interface [polypeptide binding]; other site 483179004419 N-terminal domain interface [polypeptide binding]; other site 483179004420 putative substrate binding pocket (H-site) [chemical binding]; other site 483179004421 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 483179004422 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 483179004423 nudix motif; other site 483179004424 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 483179004425 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 483179004426 active site 483179004427 metal binding site [ion binding]; metal-binding site 483179004428 2-isopropylmalate synthase; Validated; Region: PRK03739 483179004429 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 483179004430 active site 483179004431 catalytic residues [active] 483179004432 metal binding site [ion binding]; metal-binding site 483179004433 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 483179004434 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 483179004435 Cation efflux family; Region: Cation_efflux; pfam01545 483179004436 anthranilate synthase; Provisional; Region: PRK13566 483179004437 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 483179004438 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 483179004439 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 483179004440 glutamine binding [chemical binding]; other site 483179004441 catalytic triad [active] 483179004442 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 483179004443 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 483179004444 putative DNA binding site [nucleotide binding]; other site 483179004445 putative Zn2+ binding site [ion binding]; other site 483179004446 AsnC family; Region: AsnC_trans_reg; pfam01037 483179004447 Transcriptional regulators [Transcription]; Region: MarR; COG1846 483179004448 MarR family; Region: MarR_2; pfam12802 483179004449 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483179004450 putative substrate translocation pore; other site 483179004451 Major Facilitator Superfamily; Region: MFS_1; pfam07690 483179004452 Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847 483179004453 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5345 483179004454 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 483179004455 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179004456 dimer interface [polypeptide binding]; other site 483179004457 conserved gate region; other site 483179004458 putative PBP binding loops; other site 483179004459 ABC-ATPase subunit interface; other site 483179004460 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 483179004461 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483179004462 Walker A/P-loop; other site 483179004463 ATP binding site [chemical binding]; other site 483179004464 Q-loop/lid; other site 483179004465 ABC transporter signature motif; other site 483179004466 Walker B; other site 483179004467 D-loop; other site 483179004468 H-loop/switch region; other site 483179004469 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 483179004470 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 483179004471 Walker A/P-loop; other site 483179004472 ATP binding site [chemical binding]; other site 483179004473 Q-loop/lid; other site 483179004474 ABC transporter signature motif; other site 483179004475 Walker B; other site 483179004476 D-loop; other site 483179004477 H-loop/switch region; other site 483179004478 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 483179004479 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 483179004480 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 483179004481 Walker A/P-loop; other site 483179004482 ATP binding site [chemical binding]; other site 483179004483 Q-loop/lid; other site 483179004484 ABC transporter signature motif; other site 483179004485 Walker B; other site 483179004486 D-loop; other site 483179004487 H-loop/switch region; other site 483179004488 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 483179004489 dipeptide transporter; Provisional; Region: PRK10913 483179004490 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 483179004491 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179004492 dimer interface [polypeptide binding]; other site 483179004493 conserved gate region; other site 483179004494 putative PBP binding loops; other site 483179004495 ABC-ATPase subunit interface; other site 483179004496 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 483179004497 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179004498 dimer interface [polypeptide binding]; other site 483179004499 conserved gate region; other site 483179004500 putative PBP binding loops; other site 483179004501 ABC-ATPase subunit interface; other site 483179004502 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 483179004503 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 483179004504 dimerization interface [polypeptide binding]; other site 483179004505 putative DNA binding site [nucleotide binding]; other site 483179004506 putative Zn2+ binding site [ion binding]; other site 483179004507 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 483179004508 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 483179004509 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 483179004510 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 483179004511 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 483179004512 Ligand Binding Site [chemical binding]; other site 483179004513 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 483179004514 Predicted acetyltransferase [General function prediction only]; Region: COG2388 483179004515 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 483179004516 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5400 483179004517 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5385 483179004518 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 483179004519 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483179004520 active site 483179004521 phosphorylation site [posttranslational modification] 483179004522 intermolecular recognition site; other site 483179004523 dimerization interface [polypeptide binding]; other site 483179004524 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 483179004525 DNA binding site [nucleotide binding] 483179004526 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 483179004527 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 483179004528 inhibitor-cofactor binding pocket; inhibition site 483179004529 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483179004530 catalytic residue [active] 483179004531 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 483179004532 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 483179004533 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 483179004534 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 483179004535 PAS domain; Region: PAS_8; pfam13188 483179004536 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 483179004537 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483179004538 putative active site [active] 483179004539 heme pocket [chemical binding]; other site 483179004540 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483179004541 dimer interface [polypeptide binding]; other site 483179004542 phosphorylation site [posttranslational modification] 483179004543 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483179004544 ATP binding site [chemical binding]; other site 483179004545 Mg2+ binding site [ion binding]; other site 483179004546 G-X-G motif; other site 483179004547 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 483179004548 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 483179004549 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 483179004550 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179004551 dimer interface [polypeptide binding]; other site 483179004552 conserved gate region; other site 483179004553 putative PBP binding loops; other site 483179004554 ABC-ATPase subunit interface; other site 483179004555 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179004556 dimer interface [polypeptide binding]; other site 483179004557 conserved gate region; other site 483179004558 putative PBP binding loops; other site 483179004559 ABC-ATPase subunit interface; other site 483179004560 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 483179004561 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 483179004562 Walker A/P-loop; other site 483179004563 ATP binding site [chemical binding]; other site 483179004564 Q-loop/lid; other site 483179004565 ABC transporter signature motif; other site 483179004566 Walker B; other site 483179004567 D-loop; other site 483179004568 H-loop/switch region; other site 483179004569 TOBE domain; Region: TOBE_2; pfam08402 483179004570 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 483179004571 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 483179004572 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 483179004573 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 483179004574 non-specific DNA binding site [nucleotide binding]; other site 483179004575 salt bridge; other site 483179004576 sequence-specific DNA binding site [nucleotide binding]; other site 483179004577 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 483179004578 Domain of unknown function (DUF955); Region: DUF955; pfam06114 483179004579 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 483179004580 isocitrate lyase; Provisional; Region: PRK15063 483179004581 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 483179004582 tetramer interface [polypeptide binding]; other site 483179004583 active site 483179004584 Mg2+/Mn2+ binding site [ion binding]; other site 483179004585 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 483179004586 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 483179004587 NAD binding site [chemical binding]; other site 483179004588 substrate binding site [chemical binding]; other site 483179004589 homotetramer interface [polypeptide binding]; other site 483179004590 homodimer interface [polypeptide binding]; other site 483179004591 active site 483179004592 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 483179004593 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 483179004594 NAD binding site [chemical binding]; other site 483179004595 substrate binding site [chemical binding]; other site 483179004596 homotetramer interface [polypeptide binding]; other site 483179004597 homodimer interface [polypeptide binding]; other site 483179004598 active site 483179004599 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 483179004600 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 483179004601 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 483179004602 active site 483179004603 nucleophile elbow; other site 483179004604 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 483179004605 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 483179004606 DAK2 domain; Region: Dak2; cl03685 483179004607 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 483179004608 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 483179004609 DNA binding residues [nucleotide binding] 483179004610 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 483179004611 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 483179004612 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 483179004613 DAK2 domain; Region: Dak2; pfam02734 483179004614 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 483179004615 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 483179004616 short chain dehydrogenase; Provisional; Region: PRK06841 483179004617 classical (c) SDRs; Region: SDR_c; cd05233 483179004618 NAD(P) binding site [chemical binding]; other site 483179004619 active site 483179004620 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 483179004621 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 483179004622 putative ligand binding site [chemical binding]; other site 483179004623 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 483179004624 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 483179004625 TM-ABC transporter signature motif; other site 483179004626 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 483179004627 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 483179004628 Walker A/P-loop; other site 483179004629 ATP binding site [chemical binding]; other site 483179004630 Q-loop/lid; other site 483179004631 ABC transporter signature motif; other site 483179004632 Walker B; other site 483179004633 D-loop; other site 483179004634 H-loop/switch region; other site 483179004635 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 483179004636 Uncharacterized conserved protein [Function unknown]; Region: COG5591 483179004637 Transcriptional regulator [Transcription]; Region: IclR; COG1414 483179004638 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 483179004639 Bacterial transcriptional regulator; Region: IclR; pfam01614 483179004640 succinic semialdehyde dehydrogenase; Region: PLN02278 483179004641 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 483179004642 tetramerization interface [polypeptide binding]; other site 483179004643 NAD(P) binding site [chemical binding]; other site 483179004644 catalytic residues [active] 483179004645 Predicted membrane protein [Function unknown]; Region: COG1238 483179004646 Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495 483179004647 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 483179004648 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 483179004649 active site 483179004650 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 483179004651 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 483179004652 helix-hairpin-helix signature motif; other site 483179004653 substrate binding pocket [chemical binding]; other site 483179004654 active site 483179004655 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 483179004656 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 483179004657 active site 483179004658 HIGH motif; other site 483179004659 nucleotide binding site [chemical binding]; other site 483179004660 active site 483179004661 KMSKS motif; other site 483179004662 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 483179004663 active site 483179004664 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 483179004665 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 483179004666 Coenzyme A binding pocket [chemical binding]; other site 483179004667 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 483179004668 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 483179004669 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 483179004670 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 483179004671 DNA binding residues [nucleotide binding] 483179004672 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 483179004673 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 483179004674 RNA binding surface [nucleotide binding]; other site 483179004675 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 483179004676 active site 483179004677 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 483179004678 metal binding site 2 [ion binding]; metal-binding site 483179004679 putative DNA binding helix; other site 483179004680 metal binding site 1 [ion binding]; metal-binding site 483179004681 dimer interface [polypeptide binding]; other site 483179004682 structural Zn2+ binding site [ion binding]; other site 483179004683 PAS fold; Region: PAS_4; pfam08448 483179004684 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 483179004685 HWE histidine kinase; Region: HWE_HK; pfam07536 483179004686 two-component response regulator; Provisional; Region: PRK09191 483179004687 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483179004688 active site 483179004689 phosphorylation site [posttranslational modification] 483179004690 intermolecular recognition site; other site 483179004691 dimerization interface [polypeptide binding]; other site 483179004692 RNA polymerase sigma factor; Provisional; Region: PRK12516 483179004693 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 483179004694 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 483179004695 DNA binding residues [nucleotide binding] 483179004696 CHASE3 domain; Region: CHASE3; pfam05227 483179004697 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 483179004698 Histidine kinase; Region: HisKA_2; pfam07568 483179004699 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483179004700 ATP binding site [chemical binding]; other site 483179004701 Mg2+ binding site [ion binding]; other site 483179004702 G-X-G motif; other site 483179004703 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 483179004704 PRC-barrel domain; Region: PRC; pfam05239 483179004705 PRC-barrel domain; Region: PRC; pfam05239 483179004706 tonB-system energizer ExbB; Region: exbB; TIGR02797 483179004707 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 483179004708 TonB system transport protein ExbD, group 1; Region: ExbD_1; TIGR02803 483179004709 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 483179004710 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 483179004711 Predicted periplasmic protein [Function unknown]; Region: COG3698 483179004712 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 483179004713 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 483179004714 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 483179004715 Walker A/P-loop; other site 483179004716 ATP binding site [chemical binding]; other site 483179004717 Q-loop/lid; other site 483179004718 ABC transporter signature motif; other site 483179004719 Walker B; other site 483179004720 D-loop; other site 483179004721 H-loop/switch region; other site 483179004722 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 483179004723 FtsX-like permease family; Region: FtsX; pfam02687 483179004724 macrolide transporter subunit MacA; Provisional; Region: PRK11578 483179004725 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 483179004726 HlyD family secretion protein; Region: HlyD_3; pfam13437 483179004727 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 483179004728 trimer interface [polypeptide binding]; other site 483179004729 active site 483179004730 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 483179004731 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 483179004732 dimerization interface [polypeptide binding]; other site 483179004733 putative DNA binding site [nucleotide binding]; other site 483179004734 putative Zn2+ binding site [ion binding]; other site 483179004735 AsnC family; Region: AsnC_trans_reg; pfam01037 483179004736 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 483179004737 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 483179004738 putative active site [active] 483179004739 putative dimer interface [polypeptide binding]; other site 483179004740 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 483179004741 diiron binding motif [ion binding]; other site 483179004742 Uncharacterized conserved protein [Function unknown]; Region: COG1633 483179004743 CCC1-related protein family; Region: CCC1_like_1; cd02437 483179004744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483179004745 metabolite-proton symporter; Region: 2A0106; TIGR00883 483179004746 putative substrate translocation pore; other site 483179004747 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 483179004748 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 483179004749 GDP-binding site [chemical binding]; other site 483179004750 ACT binding site; other site 483179004751 IMP binding site; other site 483179004752 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 483179004753 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 483179004754 Coenzyme A binding pocket [chemical binding]; other site 483179004755 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 483179004756 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 483179004757 ligand binding site [chemical binding]; other site 483179004758 NAD binding site [chemical binding]; other site 483179004759 dimerization interface [polypeptide binding]; other site 483179004760 catalytic site [active] 483179004761 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 483179004762 putative L-serine binding site [chemical binding]; other site 483179004763 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 483179004764 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 483179004765 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 483179004766 catalytic residue [active] 483179004767 serC leader; BCAN_A1726 483179004768 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 483179004769 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 483179004770 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 483179004771 active site 483179004772 substrate binding site [chemical binding]; other site 483179004773 metal binding site [ion binding]; metal-binding site 483179004774 FtsH Extracellular; Region: FtsH_ext; pfam06480 483179004775 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 483179004776 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483179004777 Walker A motif; other site 483179004778 ATP binding site [chemical binding]; other site 483179004779 Walker B motif; other site 483179004780 arginine finger; other site 483179004781 Peptidase family M41; Region: Peptidase_M41; pfam01434 483179004782 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 483179004783 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 483179004784 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 483179004785 Tetratricopeptide repeat; Region: TPR_6; pfam13174 483179004786 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 483179004787 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 483179004788 ligand binding site [chemical binding]; other site 483179004789 translocation protein TolB; Provisional; Region: tolB; PRK05137 483179004790 TolB amino-terminal domain; Region: TolB_N; pfam04052 483179004791 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 483179004792 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 483179004793 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 483179004794 TolR protein; Region: tolR; TIGR02801 483179004795 TolQ protein; Region: tolQ; TIGR02796 483179004796 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 483179004797 active site 483179004798 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 483179004799 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483179004800 Walker A motif; other site 483179004801 ATP binding site [chemical binding]; other site 483179004802 Walker B motif; other site 483179004803 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 483179004804 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 483179004805 RuvA N terminal domain; Region: RuvA_N; pfam01330 483179004806 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 483179004807 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 483179004808 active site 483179004809 putative DNA-binding cleft [nucleotide binding]; other site 483179004810 dimer interface [polypeptide binding]; other site 483179004811 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5317 483179004812 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4645 483179004813 Acyltransferase family; Region: Acyl_transf_3; pfam01757 483179004814 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 483179004815 active site 483179004816 thiamine phosphate binding site [chemical binding]; other site 483179004817 pyrophosphate binding site [ion binding]; other site 483179004818 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 483179004819 Sel1-like repeats; Region: SEL1; smart00671 483179004820 Sel1-like repeats; Region: SEL1; smart00671 483179004821 elongation factor P; Validated; Region: PRK00529 483179004822 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 483179004823 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 483179004824 RNA binding site [nucleotide binding]; other site 483179004825 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 483179004826 RNA binding site [nucleotide binding]; other site 483179004827 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 483179004828 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 483179004829 active site 483179004830 dimerization interface [polypeptide binding]; other site 483179004831 hypothetical protein; Validated; Region: PRK09039 483179004832 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 483179004833 ligand binding site [chemical binding]; other site 483179004834 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 483179004835 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 483179004836 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483179004837 Walker A/P-loop; other site 483179004838 ATP binding site [chemical binding]; other site 483179004839 Q-loop/lid; other site 483179004840 ABC transporter signature motif; other site 483179004841 Walker B; other site 483179004842 D-loop; other site 483179004843 H-loop/switch region; other site 483179004844 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 483179004845 hypothetical protein; Validated; Region: PRK00110 483179004846 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 483179004847 Uncharacterized conserved protein [Function unknown]; Region: COG3543 483179004848 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 483179004849 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 483179004850 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 483179004851 putative active site [active] 483179004852 metal binding site [ion binding]; metal-binding site 483179004853 homodimer binding site [polypeptide binding]; other site 483179004854 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 483179004855 Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division, chromosome partitioning]; Region: zapA; COG3027 483179004856 Domain of unknown function (DUF4164); Region: DUF4164; pfam13747 483179004857 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 483179004858 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 483179004859 TPP-binding site [chemical binding]; other site 483179004860 dimer interface [polypeptide binding]; other site 483179004861 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 483179004862 PYR/PP interface [polypeptide binding]; other site 483179004863 dimer interface [polypeptide binding]; other site 483179004864 TPP binding site [chemical binding]; other site 483179004865 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 483179004866 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 483179004867 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 483179004868 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 483179004869 Phosphoglycerate kinase; Region: PGK; pfam00162 483179004870 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 483179004871 substrate binding site [chemical binding]; other site 483179004872 hinge regions; other site 483179004873 ADP binding site [chemical binding]; other site 483179004874 catalytic site [active] 483179004875 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 483179004876 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 483179004877 acyl-activating enzyme (AAE) consensus motif; other site 483179004878 putative AMP binding site [chemical binding]; other site 483179004879 putative active site [active] 483179004880 putative CoA binding site [chemical binding]; other site 483179004881 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483179004882 Predicted transcriptional regulator [Transcription]; Region: COG2378 483179004883 HTH domain; Region: HTH_11; pfam08279 483179004884 WYL domain; Region: WYL; pfam13280 483179004885 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 483179004886 CoenzymeA binding site [chemical binding]; other site 483179004887 subunit interaction site [polypeptide binding]; other site 483179004888 PHB binding site; other site 483179004889 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 483179004890 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820 483179004891 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 483179004892 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 483179004893 NAD(P) binding site [chemical binding]; other site 483179004894 Uncharacterized small protein containing a coiled-coil domain [Function unknown]; Region: COG5509 483179004895 putative MFS family transporter protein; Provisional; Region: PRK03633 483179004896 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483179004897 putative substrate translocation pore; other site 483179004898 Uncharacterized small protein [Function unknown]; Region: COG5570 483179004899 Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481 483179004900 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 483179004901 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 483179004902 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 483179004903 NAD binding site [chemical binding]; other site 483179004904 ATP-grasp domain; Region: ATP-grasp; pfam02222 483179004905 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 483179004906 TPR repeat; Region: TPR_11; pfam13414 483179004907 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483179004908 TPR motif; other site 483179004909 binding surface 483179004910 pyruvate kinase; Provisional; Region: PRK06247 483179004911 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 483179004912 domain interfaces; other site 483179004913 active site 483179004914 Predicted integral membrane protein [Function unknown]; Region: COG5480 483179004915 Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931 483179004916 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3750 483179004917 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 483179004918 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 483179004919 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 483179004920 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 483179004921 Thiamine pyrophosphokinase; Region: TPK; cd07995 483179004922 active site 483179004923 dimerization interface [polypeptide binding]; other site 483179004924 thiamine binding site [chemical binding]; other site 483179004925 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 483179004926 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 483179004927 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 483179004928 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179004929 dimer interface [polypeptide binding]; other site 483179004930 conserved gate region; other site 483179004931 putative PBP binding loops; other site 483179004932 ABC-ATPase subunit interface; other site 483179004933 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179004934 dimer interface [polypeptide binding]; other site 483179004935 conserved gate region; other site 483179004936 putative PBP binding loops; other site 483179004937 ABC-ATPase subunit interface; other site 483179004938 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 483179004939 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 483179004940 Walker A/P-loop; other site 483179004941 ATP binding site [chemical binding]; other site 483179004942 Q-loop/lid; other site 483179004943 ABC transporter signature motif; other site 483179004944 Walker B; other site 483179004945 D-loop; other site 483179004946 H-loop/switch region; other site 483179004947 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 483179004948 Peptidase family M48; Region: Peptidase_M48; pfam01435 483179004949 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 483179004950 MOSC domain; Region: MOSC; pfam03473 483179004951 3-alpha domain; Region: 3-alpha; pfam03475 483179004952 RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500 483179004953 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 483179004954 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 483179004955 DNA binding residues [nucleotide binding] 483179004956 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 483179004957 Ferredoxin [Energy production and conversion]; Region: COG1146 483179004958 4Fe-4S binding domain; Region: Fer4; pfam00037 483179004959 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 483179004960 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 483179004961 RNA binding surface [nucleotide binding]; other site 483179004962 putative acyltransferase; Provisional; Region: PRK05790 483179004963 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 483179004964 dimer interface [polypeptide binding]; other site 483179004965 active site 483179004966 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 483179004967 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 483179004968 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 483179004969 Transglycosylase; Region: Transgly; pfam00912 483179004970 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 483179004971 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 483179004972 substrate binding pocket [chemical binding]; other site 483179004973 chain length determination region; other site 483179004974 substrate-Mg2+ binding site; other site 483179004975 catalytic residues [active] 483179004976 aspartate-rich region 1; other site 483179004977 active site lid residues [active] 483179004978 aspartate-rich region 2; other site 483179004979 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 483179004980 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 483179004981 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 483179004982 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 483179004983 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483179004984 NAD(P) binding site [chemical binding]; other site 483179004985 active site 483179004986 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483179004987 Major Facilitator Superfamily; Region: MFS_1; pfam07690 483179004988 putative substrate translocation pore; other site 483179004989 pyruvate carboxylase; Reviewed; Region: PRK12999 483179004990 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 483179004991 ATP-grasp domain; Region: ATP-grasp_4; cl17255 483179004992 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 483179004993 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 483179004994 active site 483179004995 catalytic residues [active] 483179004996 metal binding site [ion binding]; metal-binding site 483179004997 homodimer binding site [polypeptide binding]; other site 483179004998 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 483179004999 carboxyltransferase (CT) interaction site; other site 483179005000 biotinylation site [posttranslational modification]; other site 483179005001 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 483179005002 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 483179005003 dimerization interface [polypeptide binding]; other site 483179005004 ligand binding site [chemical binding]; other site 483179005005 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 483179005006 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 483179005007 dimerization interface [polypeptide binding]; other site 483179005008 ligand binding site [chemical binding]; other site 483179005009 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 483179005010 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 483179005011 Walker A/P-loop; other site 483179005012 ATP binding site [chemical binding]; other site 483179005013 Q-loop/lid; other site 483179005014 ABC transporter signature motif; other site 483179005015 Walker B; other site 483179005016 D-loop; other site 483179005017 H-loop/switch region; other site 483179005018 Uncharacterized conserved protein [Function unknown]; Region: COG3743 483179005019 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 483179005020 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 483179005021 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 483179005022 TM-ABC transporter signature motif; other site 483179005023 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 483179005024 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 483179005025 TM-ABC transporter signature motif; other site 483179005026 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 483179005027 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 483179005028 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 483179005029 MarR family; Region: MarR; pfam01047 483179005030 transcriptional regulator SlyA; Provisional; Region: PRK03573 483179005031 F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]; Region: AtpC; COG0355 483179005032 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 483179005033 gamma subunit interface [polypeptide binding]; other site 483179005034 epsilon subunit interface [polypeptide binding]; other site 483179005035 LBP interface [polypeptide binding]; other site 483179005036 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 483179005037 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 483179005038 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 483179005039 alpha subunit interaction interface [polypeptide binding]; other site 483179005040 Walker A motif; other site 483179005041 ATP binding site [chemical binding]; other site 483179005042 Walker B motif; other site 483179005043 inhibitor binding site; inhibition site 483179005044 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 483179005045 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 483179005046 core domain interface [polypeptide binding]; other site 483179005047 delta subunit interface [polypeptide binding]; other site 483179005048 epsilon subunit interface [polypeptide binding]; other site 483179005049 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 483179005050 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 483179005051 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 483179005052 beta subunit interaction interface [polypeptide binding]; other site 483179005053 Walker A motif; other site 483179005054 ATP binding site [chemical binding]; other site 483179005055 Walker B motif; other site 483179005056 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 483179005057 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 483179005058 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 483179005059 primosome assembly protein PriA; Validated; Region: PRK05580 483179005060 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 483179005061 ATP binding site [chemical binding]; other site 483179005062 putative Mg++ binding site [ion binding]; other site 483179005063 helicase superfamily c-terminal domain; Region: HELICc; smart00490 483179005064 nucleotide binding region [chemical binding]; other site 483179005065 ATP-binding site [chemical binding]; other site 483179005066 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 483179005067 active site 483179005068 intersubunit interactions; other site 483179005069 catalytic residue [active] 483179005070 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5468 483179005071 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 483179005072 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 483179005073 HIGH motif; other site 483179005074 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 483179005075 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 483179005076 active site 483179005077 KMSKS motif; other site 483179005078 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 483179005079 tRNA binding surface [nucleotide binding]; other site 483179005080 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 483179005081 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 483179005082 catalytic residue [active] 483179005083 Predicted membrane protein [Function unknown]; Region: COG1289 483179005084 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 483179005085 Usg protein, probable subunit of phosphoribosylanthranilate isomerase [Amino acid transport and metabolism]; Region: COG5425 483179005086 acetyl-CoA synthetase; Provisional; Region: PRK00174 483179005087 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 483179005088 active site 483179005089 CoA binding site [chemical binding]; other site 483179005090 acyl-activating enzyme (AAE) consensus motif; other site 483179005091 AMP binding site [chemical binding]; other site 483179005092 acetate binding site [chemical binding]; other site 483179005093 Uncharacterized conserved small protein [Function unknown]; Region: COG5508 483179005094 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 483179005095 heat shock protein HtpX; Provisional; Region: PRK01345 483179005096 NusB family; Region: NusB; pfam01029 483179005097 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 483179005098 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483179005099 S-adenosylmethionine binding site [chemical binding]; other site 483179005100 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5360 483179005101 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 483179005102 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 483179005103 purine monophosphate binding site [chemical binding]; other site 483179005104 dimer interface [polypeptide binding]; other site 483179005105 putative catalytic residues [active] 483179005106 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 483179005107 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 483179005108 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 483179005109 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 483179005110 Predicted membrane protein [Function unknown]; Region: COG3762 483179005111 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 483179005112 Repair protein; Region: Repair_PSII; pfam04536 483179005113 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 483179005114 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 483179005115 chorismate mutase; Provisional; Region: PRK09239 483179005116 signal recognition particle protein; Provisional; Region: PRK10867 483179005117 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 483179005118 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 483179005119 P loop; other site 483179005120 GTP binding site [chemical binding]; other site 483179005121 Signal peptide binding domain; Region: SRP_SPB; pfam02978 483179005122 lytic murein transglycosylase; Region: MltB_2; TIGR02283 483179005123 murein hydrolase B; Provisional; Region: PRK10760; cl17906 483179005124 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 483179005125 active site clefts [active] 483179005126 zinc binding site [ion binding]; other site 483179005127 dimer interface [polypeptide binding]; other site 483179005128 pyridoxamine kinase; Validated; Region: PRK05756 483179005129 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 483179005130 dimer interface [polypeptide binding]; other site 483179005131 pyridoxal binding site [chemical binding]; other site 483179005132 ATP binding site [chemical binding]; other site 483179005133 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 483179005134 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 483179005135 tetrameric interface [polypeptide binding]; other site 483179005136 NAD binding site [chemical binding]; other site 483179005137 catalytic residues [active] 483179005138 Transcriptional regulator [Transcription]; Region: LysR; COG0583 483179005139 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 483179005140 putative effector binding pocket; other site 483179005141 dimerization interface [polypeptide binding]; other site 483179005142 Predicted membrane protein [Function unknown]; Region: COG3619 483179005143 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 483179005144 putative active site [active] 483179005145 Ap4A binding site [chemical binding]; other site 483179005146 nudix motif; other site 483179005147 putative metal binding site [ion binding]; other site 483179005148 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 483179005149 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 483179005150 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 483179005151 protein binding site [polypeptide binding]; other site 483179005152 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 483179005153 Catalytic dyad [active] 483179005154 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 483179005155 Peptidase family M23; Region: Peptidase_M23; pfam01551 483179005156 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 483179005157 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 483179005158 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 483179005159 active site 483179005160 (T/H)XGH motif; other site 483179005161 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 483179005162 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 483179005163 putative catalytic cysteine [active] 483179005164 gamma-glutamyl kinase; Provisional; Region: PRK05429 483179005165 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 483179005166 nucleotide binding site [chemical binding]; other site 483179005167 homotetrameric interface [polypeptide binding]; other site 483179005168 putative phosphate binding site [ion binding]; other site 483179005169 putative allosteric binding site; other site 483179005170 PUA domain; Region: PUA; pfam01472 483179005171 GTPase CgtA; Reviewed; Region: obgE; PRK12299 483179005172 GTP1/OBG; Region: GTP1_OBG; pfam01018 483179005173 Obg GTPase; Region: Obg; cd01898 483179005174 G1 box; other site 483179005175 GTP/Mg2+ binding site [chemical binding]; other site 483179005176 Switch I region; other site 483179005177 G2 box; other site 483179005178 G3 box; other site 483179005179 Switch II region; other site 483179005180 G4 box; other site 483179005181 G5 box; other site 483179005182 YadA-like C-terminal region; Region: YadA; pfam03895 483179005183 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 483179005184 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 483179005185 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 483179005186 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 483179005187 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 483179005188 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 483179005189 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 483179005190 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 483179005191 Integrase core domain; Region: rve; pfam00665 483179005192 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 483179005193 non-specific DNA binding site [nucleotide binding]; other site 483179005194 salt bridge; other site 483179005195 sequence-specific DNA binding site [nucleotide binding]; other site 483179005196 Cupin domain; Region: Cupin_2; cl17218 483179005197 Methyltransferase domain; Region: Methyltransf_31; pfam13847 483179005198 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483179005199 S-adenosylmethionine binding site [chemical binding]; other site 483179005200 AzlC protein; Region: AzlC; pfam03591 483179005201 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 483179005202 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 483179005203 Integrase core domain; Region: rve; pfam00665 483179005204 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 483179005205 Peptidase family M23; Region: Peptidase_M23; pfam01551 483179005206 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 483179005207 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 483179005208 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 483179005209 Clp amino terminal domain; Region: Clp_N; pfam02861 483179005210 Clp amino terminal domain; Region: Clp_N; pfam02861 483179005211 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483179005212 Walker A motif; other site 483179005213 ATP binding site [chemical binding]; other site 483179005214 Walker B motif; other site 483179005215 arginine finger; other site 483179005216 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483179005217 Walker A motif; other site 483179005218 ATP binding site [chemical binding]; other site 483179005219 Walker B motif; other site 483179005220 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 483179005221 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 483179005222 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 483179005223 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483179005224 S-adenosylmethionine binding site [chemical binding]; other site 483179005225 peptide chain release factor 1; Validated; Region: prfA; PRK00591 483179005226 This domain is found in peptide chain release factors; Region: PCRF; smart00937 483179005227 RF-1 domain; Region: RF-1; pfam00472 483179005228 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 483179005229 GAF domain; Region: GAF; pfam01590 483179005230 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 483179005231 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 483179005232 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 483179005233 aspartate kinase; Reviewed; Region: PRK06635 483179005234 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 483179005235 putative nucleotide binding site [chemical binding]; other site 483179005236 putative catalytic residues [active] 483179005237 putative Mg ion binding site [ion binding]; other site 483179005238 putative aspartate binding site [chemical binding]; other site 483179005239 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 483179005240 putative allosteric regulatory site; other site 483179005241 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 483179005242 putative allosteric regulatory residue; other site 483179005243 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 483179005244 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483179005245 S-adenosylmethionine binding site [chemical binding]; other site 483179005246 EamA-like transporter family; Region: EamA; pfam00892 483179005247 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 483179005248 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5319 483179005249 Predicted amidohydrolase [General function prediction only]; Region: COG0388 483179005250 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 483179005251 putative active site [active] 483179005252 catalytic triad [active] 483179005253 dimer interface [polypeptide binding]; other site 483179005254 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 483179005255 GSH binding site [chemical binding]; other site 483179005256 catalytic residues [active] 483179005257 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 483179005258 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 483179005259 active site 483179005260 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 483179005261 Methyltransferase domain; Region: Methyltransf_11; pfam08241 483179005262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483179005263 putative substrate translocation pore; other site 483179005264 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 483179005265 putative metal binding site [ion binding]; other site 483179005266 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 483179005267 HemY protein N-terminus; Region: HemY_N; pfam07219 483179005268 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223 483179005269 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 483179005270 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 483179005271 active site 483179005272 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 483179005273 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 483179005274 domain interfaces; other site 483179005275 active site 483179005276 UGMP family protein; Validated; Region: PRK09604 483179005277 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 483179005278 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 483179005279 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 483179005280 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 483179005281 YCII-related domain; Region: YCII; cl00999 483179005282 Uncharacterized conserved protein [Function unknown]; Region: COG2947 483179005283 Predicted methyltransferase [General function prediction only]; Region: COG3897 483179005284 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483179005285 S-adenosylmethionine binding site [chemical binding]; other site 483179005286 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 483179005287 EamA-like transporter family; Region: EamA; pfam00892 483179005288 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 483179005289 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 483179005290 DNA-binding site [nucleotide binding]; DNA binding site 483179005291 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 483179005292 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483179005293 homodimer interface [polypeptide binding]; other site 483179005294 catalytic residue [active] 483179005295 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 483179005296 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 483179005297 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 483179005298 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 483179005299 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 483179005300 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 483179005301 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 483179005302 active site 483179005303 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 483179005304 catalytic triad [active] 483179005305 dimer interface [polypeptide binding]; other site 483179005306 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333 483179005307 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 483179005308 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 483179005309 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 483179005310 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 483179005311 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 483179005312 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 483179005313 L-aspartate oxidase; Provisional; Region: PRK06175 483179005314 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 483179005315 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 483179005316 putative SdhC subunit interface [polypeptide binding]; other site 483179005317 putative proximal heme binding site [chemical binding]; other site 483179005318 putative Iron-sulfur protein interface [polypeptide binding]; other site 483179005319 putative proximal quinone binding site; other site 483179005320 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 483179005321 Iron-sulfur protein interface; other site 483179005322 proximal quinone binding site [chemical binding]; other site 483179005323 SdhD (CybS) interface [polypeptide binding]; other site 483179005324 proximal heme binding site [chemical binding]; other site 483179005325 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 483179005326 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 483179005327 Coenzyme A binding pocket [chemical binding]; other site 483179005328 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 483179005329 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 483179005330 substrate binding site [chemical binding]; other site 483179005331 ligand binding site [chemical binding]; other site 483179005332 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 483179005333 Cytosine/uracil/thiamine/allantoin permeases [Nucleotide transport and metabolism / Coenzyme metabolism]; Region: FUI1; COG1953 483179005334 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 483179005335 Na binding site [ion binding]; other site 483179005336 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 483179005337 NIPSNAP; Region: NIPSNAP; pfam07978 483179005338 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 483179005339 dimerization interface [polypeptide binding]; other site 483179005340 putative DNA binding site [nucleotide binding]; other site 483179005341 putative Zn2+ binding site [ion binding]; other site 483179005342 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 483179005343 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 483179005344 RimM N-terminal domain; Region: RimM; pfam01782 483179005345 PRC-barrel domain; Region: PRC; pfam05239 483179005346 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 483179005347 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 483179005348 active site 483179005349 DNA binding site [nucleotide binding] 483179005350 Int/Topo IB signature motif; other site 483179005351 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 483179005352 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 483179005353 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 483179005354 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 483179005355 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 483179005356 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 483179005357 Predicted membrane protein [Function unknown]; Region: COG3686 483179005358 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 483179005359 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 483179005360 E3 interaction surface; other site 483179005361 lipoyl attachment site [posttranslational modification]; other site 483179005362 e3 binding domain; Region: E3_binding; pfam02817 483179005363 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 483179005364 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 483179005365 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 483179005366 TPP-binding site [chemical binding]; other site 483179005367 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 483179005368 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 483179005369 CoA binding domain; Region: CoA_binding; smart00881 483179005370 CoA-ligase; Region: Ligase_CoA; pfam00549 483179005371 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 483179005372 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 483179005373 CoA-ligase; Region: Ligase_CoA; pfam00549 483179005374 malate dehydrogenase; Reviewed; Region: PRK06223 483179005375 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 483179005376 NAD(P) binding site [chemical binding]; other site 483179005377 dimer interface [polypeptide binding]; other site 483179005378 tetramer (dimer of dimers) interface [polypeptide binding]; other site 483179005379 substrate binding site [chemical binding]; other site 483179005380 Predicted ATPase [General function prediction only]; Region: COG1485 483179005381 Protease inhibitor Inh; Region: Inh; pfam02974 483179005382 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 483179005383 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 483179005384 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 483179005385 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 483179005386 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 483179005387 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 483179005388 FeS/SAM binding site; other site 483179005389 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 483179005390 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 483179005391 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 483179005392 intracellular septation protein A; Reviewed; Region: PRK00259 483179005393 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 483179005394 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 483179005395 active site 483179005396 8-oxo-dGMP binding site [chemical binding]; other site 483179005397 nudix motif; other site 483179005398 metal binding site [ion binding]; metal-binding site 483179005399 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 483179005400 Coenzyme A binding pocket [chemical binding]; other site 483179005401 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 483179005402 heterotetramer interface [polypeptide binding]; other site 483179005403 active site pocket [active] 483179005404 cleavage site 483179005405 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 483179005406 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 483179005407 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 483179005408 DEAD/DEAH box helicase; Region: DEAD; pfam00270 483179005409 ATP binding site [chemical binding]; other site 483179005410 putative Mg++ binding site [ion binding]; other site 483179005411 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 483179005412 SEC-C motif; Region: SEC-C; pfam02810 483179005413 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 483179005414 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 483179005415 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 483179005416 Sulfatase; Region: Sulfatase; pfam00884 483179005417 Transcriptional regulator [Transcription]; Region: LysR; COG0583 483179005418 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 483179005419 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 483179005420 dimerization interface [polypeptide binding]; other site 483179005421 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 483179005422 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 483179005423 substrate binding pocket [chemical binding]; other site 483179005424 membrane-bound complex binding site; other site 483179005425 hinge residues; other site 483179005426 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 483179005427 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179005428 dimer interface [polypeptide binding]; other site 483179005429 conserved gate region; other site 483179005430 putative PBP binding loops; other site 483179005431 ABC-ATPase subunit interface; other site 483179005432 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 483179005433 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179005434 dimer interface [polypeptide binding]; other site 483179005435 conserved gate region; other site 483179005436 putative PBP binding loops; other site 483179005437 ABC-ATPase subunit interface; other site 483179005438 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 483179005439 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 483179005440 Walker A/P-loop; other site 483179005441 ATP binding site [chemical binding]; other site 483179005442 Q-loop/lid; other site 483179005443 ABC transporter signature motif; other site 483179005444 Walker B; other site 483179005445 D-loop; other site 483179005446 H-loop/switch region; other site 483179005447 agmatinase; Region: agmatinase; TIGR01230 483179005448 Agmatinase and related proteins; Region: Agmatinase_like_1; cd11589 483179005449 oligomer interface [polypeptide binding]; other site 483179005450 active site 483179005451 Mn binding site [ion binding]; other site 483179005452 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 483179005453 Aspartase; Region: Aspartase; cd01357 483179005454 active sites [active] 483179005455 tetramer interface [polypeptide binding]; other site 483179005456 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 483179005457 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 483179005458 Walker A/P-loop; other site 483179005459 ATP binding site [chemical binding]; other site 483179005460 Q-loop/lid; other site 483179005461 ABC transporter signature motif; other site 483179005462 Walker B; other site 483179005463 D-loop; other site 483179005464 H-loop/switch region; other site 483179005465 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 483179005466 active site 483179005467 homotetramer interface [polypeptide binding]; other site 483179005468 homodimer interface [polypeptide binding]; other site 483179005469 Transcriptional regulators [Transcription]; Region: GntR; COG1802 483179005470 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 483179005471 DNA-binding site [nucleotide binding]; DNA binding site 483179005472 FCD domain; Region: FCD; pfam07729 483179005473 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 483179005474 active site 483179005475 homotetramer interface [polypeptide binding]; other site 483179005476 homodimer interface [polypeptide binding]; other site 483179005477 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483179005478 D-galactonate transporter; Region: 2A0114; TIGR00893 483179005479 putative substrate translocation pore; other site 483179005480 methionine gamma-lyase; Validated; Region: PRK07049 483179005481 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 483179005482 homodimer interface [polypeptide binding]; other site 483179005483 substrate-cofactor binding pocket; other site 483179005484 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483179005485 catalytic residue [active] 483179005486 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 483179005487 Ligand Binding Site [chemical binding]; other site 483179005488 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 483179005489 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 483179005490 dimer interface [polypeptide binding]; other site 483179005491 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483179005492 catalytic residue [active] 483179005493 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 483179005494 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 483179005495 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 483179005496 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 483179005497 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 483179005498 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 483179005499 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 483179005500 Ligand binding site [chemical binding]; other site 483179005501 Electron transfer flavoprotein domain; Region: ETF; pfam01012 483179005502 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 483179005503 Ligand Binding Site [chemical binding]; other site 483179005504 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 483179005505 active site 483179005506 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 483179005507 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 483179005508 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 483179005509 short chain dehydrogenase; Provisional; Region: PRK05993 483179005510 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 483179005511 NADP binding site [chemical binding]; other site 483179005512 active site 483179005513 steroid binding site; other site 483179005514 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 483179005515 hypothetical protein; Validated; Region: PRK00124 483179005516 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 483179005517 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 483179005518 catalytic residues [active] 483179005519 argininosuccinate lyase; Provisional; Region: PRK00855 483179005520 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 483179005521 active sites [active] 483179005522 tetramer interface [polypeptide binding]; other site 483179005523 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 483179005524 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 483179005525 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 483179005526 active site 483179005527 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 483179005528 substrate binding site [chemical binding]; other site 483179005529 catalytic residues [active] 483179005530 dimer interface [polypeptide binding]; other site 483179005531 TIGR02302 family protein; Region: aProt_lowcomp 483179005532 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 483179005533 active site 483179005534 Methyltransferase domain; Region: Methyltransf_23; pfam13489 483179005535 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483179005536 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 483179005537 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 483179005538 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483179005539 homodimer interface [polypeptide binding]; other site 483179005540 catalytic residue [active] 483179005541 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 483179005542 prephenate dehydrogenase; Validated; Region: PRK08507 483179005543 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4093 483179005544 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 483179005545 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 483179005546 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 483179005547 putative active site pocket [active] 483179005548 dimerization interface [polypeptide binding]; other site 483179005549 putative catalytic residue [active] 483179005550 YGGT family; Region: YGGT; pfam02325 483179005551 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 483179005552 dimer interface [polypeptide binding]; other site 483179005553 substrate binding site [chemical binding]; other site 483179005554 metal binding sites [ion binding]; metal-binding site 483179005555 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 483179005556 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 483179005557 putative acyl-acceptor binding pocket; other site 483179005558 Uncharacterized conserved protein [Function unknown]; Region: COG1434 483179005559 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 483179005560 putative active site [active] 483179005561 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 483179005562 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 483179005563 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 483179005564 Walker A/P-loop; other site 483179005565 ATP binding site [chemical binding]; other site 483179005566 Q-loop/lid; other site 483179005567 ABC transporter signature motif; other site 483179005568 Walker B; other site 483179005569 D-loop; other site 483179005570 H-loop/switch region; other site 483179005571 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 483179005572 amphipathic channel; other site 483179005573 Asn-Pro-Ala signature motifs; other site 483179005574 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 483179005575 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 483179005576 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 483179005577 putative catalytic site [active] 483179005578 putative phosphate binding site [ion binding]; other site 483179005579 active site 483179005580 metal binding site A [ion binding]; metal-binding site 483179005581 DNA binding site [nucleotide binding] 483179005582 putative AP binding site [nucleotide binding]; other site 483179005583 putative metal binding site B [ion binding]; other site 483179005584 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 483179005585 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 483179005586 ligand binding site [chemical binding]; other site 483179005587 flexible hinge region; other site 483179005588 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 483179005589 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483179005590 active site 483179005591 phosphorylation site [posttranslational modification] 483179005592 intermolecular recognition site; other site 483179005593 dimerization interface [polypeptide binding]; other site 483179005594 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 483179005595 DNA binding site [nucleotide binding] 483179005596 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 483179005597 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 483179005598 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 483179005599 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 483179005600 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 483179005601 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 483179005602 DNA binding residues [nucleotide binding] 483179005603 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 483179005604 dimer interface [polypeptide binding]; other site 483179005605 putative metal binding site [ion binding]; other site 483179005606 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 483179005607 metal-binding site [ion binding] 483179005608 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 483179005609 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 483179005610 metal-binding site [ion binding] 483179005611 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 483179005612 Soluble P-type ATPase [General function prediction only]; Region: COG4087 483179005613 Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase) [Coenzyme metabolism]; Region: CobT; COG4547 483179005614 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 483179005615 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 483179005616 metal ion-dependent adhesion site (MIDAS); other site 483179005617 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 483179005618 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 483179005619 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 483179005620 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 483179005621 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 483179005622 HSP70 interaction site [polypeptide binding]; other site 483179005623 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 483179005624 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 483179005625 Domain of unknown function DUF21; Region: DUF21; pfam01595 483179005626 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 483179005627 Transporter associated domain; Region: CorC_HlyC; smart01091 483179005628 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 483179005629 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 483179005630 active site 483179005631 dimer interface [polypeptide binding]; other site 483179005632 metal binding site [ion binding]; metal-binding site 483179005633 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 483179005634 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 483179005635 ADP binding site [chemical binding]; other site 483179005636 magnesium binding site [ion binding]; other site 483179005637 putative shikimate binding site; other site 483179005638 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 483179005639 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 483179005640 active site 483179005641 DNA binding site [nucleotide binding] 483179005642 Int/Topo IB signature motif; other site 483179005643 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 483179005644 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 483179005645 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 483179005646 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 483179005647 CPxP motif; other site 483179005648 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 483179005649 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 483179005650 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 483179005651 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 483179005652 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 483179005653 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 483179005654 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 483179005655 metal binding site [ion binding]; metal-binding site 483179005656 putative dimer interface [polypeptide binding]; other site 483179005657 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 483179005658 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483179005659 NAD(P) binding site [chemical binding]; other site 483179005660 active site 483179005661 Uncharacterized conserved protein [Function unknown]; Region: COG3791 483179005662 Domain of unknown function (DUF4354); Region: DUF4354; pfam14263 483179005663 choline dehydrogenase; Validated; Region: PRK02106 483179005664 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 483179005665 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 483179005666 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483179005667 NAD(P) binding site [chemical binding]; other site 483179005668 active site 483179005669 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 483179005670 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 483179005671 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 483179005672 Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118 483179005673 NAD(P) binding site [chemical binding]; other site 483179005674 catalytic residues [active] 483179005675 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 483179005676 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 483179005677 substrate binding site [chemical binding]; other site 483179005678 oxyanion hole (OAH) forming residues; other site 483179005679 trimer interface [polypeptide binding]; other site 483179005680 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 483179005681 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 483179005682 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 483179005683 Transcriptional regulators [Transcription]; Region: PurR; COG1609 483179005684 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 483179005685 DNA binding site [nucleotide binding] 483179005686 domain linker motif; other site 483179005687 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 483179005688 putative dimerization interface [polypeptide binding]; other site 483179005689 putative ligand binding site [chemical binding]; other site 483179005690 Protein of unknown function (DUF993); Region: DUF993; pfam06187 483179005691 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 483179005692 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 483179005693 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 483179005694 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 483179005695 zinc binding site [ion binding]; other site 483179005696 putative ligand binding site [chemical binding]; other site 483179005697 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 483179005698 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 483179005699 TM-ABC transporter signature motif; other site 483179005700 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 483179005701 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 483179005702 Walker A/P-loop; other site 483179005703 ATP binding site [chemical binding]; other site 483179005704 Q-loop/lid; other site 483179005705 ABC transporter signature motif; other site 483179005706 Walker B; other site 483179005707 D-loop; other site 483179005708 H-loop/switch region; other site 483179005709 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 483179005710 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 483179005711 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 483179005712 ParB-like nuclease domain; Region: ParB; smart00470 483179005713 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 483179005714 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 483179005715 P-loop; other site 483179005716 Magnesium ion binding site [ion binding]; other site 483179005717 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 483179005718 Magnesium ion binding site [ion binding]; other site 483179005719 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 483179005720 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 483179005721 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 483179005722 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 483179005723 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 483179005724 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 483179005725 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 483179005726 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 483179005727 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 483179005728 trmE is a tRNA modification GTPase; Region: trmE; cd04164 483179005729 G1 box; other site 483179005730 G1 box; other site 483179005731 GTP/Mg2+ binding site [chemical binding]; other site 483179005732 GTP/Mg2+ binding site [chemical binding]; other site 483179005733 Switch I region; other site 483179005734 Switch I region; other site 483179005735 G2 box; other site 483179005736 G2 box; other site 483179005737 Switch II region; other site 483179005738 G3 box; other site 483179005739 G4 box; other site 483179005740 G5 box; other site 483179005741 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 483179005742 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 483179005743 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 483179005744 catalytic residues [active] 483179005745 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 483179005746 transcription termination factor Rho; Provisional; Region: rho; PRK09376 483179005747 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 483179005748 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 483179005749 RNA binding site [nucleotide binding]; other site 483179005750 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 483179005751 multimer interface [polypeptide binding]; other site 483179005752 Walker A motif; other site 483179005753 ATP binding site [chemical binding]; other site 483179005754 Walker B motif; other site 483179005755 Predicted membrane protein [Function unknown]; Region: COG1981 483179005756 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 483179005757 substrate binding site [chemical binding]; other site 483179005758 active site 483179005759 PEP synthetase regulatory protein; Provisional; Region: PRK05339 483179005760 Maf-like protein; Reviewed; Region: PRK00078 483179005761 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 483179005762 active site 483179005763 dimer interface [polypeptide binding]; other site 483179005764 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 483179005765 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 483179005766 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 483179005767 shikimate binding site; other site 483179005768 NAD(P) binding site [chemical binding]; other site 483179005769 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 483179005770 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 483179005771 CoA-binding site [chemical binding]; other site 483179005772 ATP-binding [chemical binding]; other site 483179005773 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 483179005774 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 483179005775 active site 483179005776 catalytic site [active] 483179005777 substrate binding site [chemical binding]; other site 483179005778 preprotein translocase subunit SecB; Validated; Region: PRK05751 483179005779 SecA binding site; other site 483179005780 Preprotein binding site; other site 483179005781 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 483179005782 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 483179005783 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 483179005784 MltA specific insert domain; Region: MltA; pfam03562 483179005785 3D domain; Region: 3D; pfam06725 483179005786 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 483179005787 Smr domain; Region: Smr; pfam01713 483179005788 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 483179005789 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 483179005790 sequence-specific DNA binding site [nucleotide binding]; other site 483179005791 salt bridge; other site 483179005792 Protein of unknown function (DUF1402); Region: DUF1402; pfam07182 483179005793 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 483179005794 active site 483179005795 HslU subunit interaction site [polypeptide binding]; other site 483179005796 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 483179005797 putative active site pocket [active] 483179005798 4-fold oligomerization interface [polypeptide binding]; other site 483179005799 metal binding residues [ion binding]; metal-binding site 483179005800 3-fold/trimer interface [polypeptide binding]; other site 483179005801 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 483179005802 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 483179005803 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 483179005804 putative active site [active] 483179005805 oxyanion strand; other site 483179005806 catalytic triad [active] 483179005807 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 483179005808 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 483179005809 catalytic residues [active] 483179005810 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 483179005811 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 483179005812 substrate binding site [chemical binding]; other site 483179005813 glutamase interaction surface [polypeptide binding]; other site 483179005814 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 483179005815 metal binding site [ion binding]; metal-binding site 483179005816 pantothenate kinase; Provisional; Region: PRK05439 483179005817 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 483179005818 ATP-binding site [chemical binding]; other site 483179005819 CoA-binding site [chemical binding]; other site 483179005820 Mg2+-binding site [ion binding]; other site 483179005821 hypothetical protein; Provisional; Region: PRK09256 483179005822 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 483179005823 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 483179005824 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 483179005825 active site 483179005826 substrate-binding site [chemical binding]; other site 483179005827 metal-binding site [ion binding] 483179005828 ATP binding site [chemical binding]; other site 483179005829 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 483179005830 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483179005831 active site 483179005832 phosphorylation site [posttranslational modification] 483179005833 intermolecular recognition site; other site 483179005834 dimerization interface [polypeptide binding]; other site 483179005835 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 483179005836 DNA binding site [nucleotide binding] 483179005837 Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755 483179005838 Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756 483179005839 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483179005840 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483179005841 dimerization interface [polypeptide binding]; other site 483179005842 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483179005843 dimer interface [polypeptide binding]; other site 483179005844 phosphorylation site [posttranslational modification] 483179005845 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483179005846 ATP binding site [chemical binding]; other site 483179005847 Mg2+ binding site [ion binding]; other site 483179005848 G-X-G motif; other site 483179005849 Serine kinase of the HPr protein, regulates carbohydrate metabolism [Signal transduction mechanisms]; Region: HprK; COG1493 483179005850 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 483179005851 Hpr binding site; other site 483179005852 active site 483179005853 homohexamer subunit interaction site [polypeptide binding]; other site 483179005854 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 483179005855 active pocket/dimerization site; other site 483179005856 active site 483179005857 phosphorylation site [posttranslational modification] 483179005858 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 483179005859 dimerization domain swap beta strand [polypeptide binding]; other site 483179005860 regulatory protein interface [polypeptide binding]; other site 483179005861 active site 483179005862 regulatory phosphorylation site [posttranslational modification]; other site 483179005863 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 483179005864 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 483179005865 homotetramer interface [polypeptide binding]; other site 483179005866 ligand binding site [chemical binding]; other site 483179005867 catalytic site [active] 483179005868 NAD binding site [chemical binding]; other site 483179005869 PAS fold; Region: PAS_7; pfam12860 483179005870 PAS fold; Region: PAS_7; pfam12860 483179005871 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483179005872 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483179005873 dimer interface [polypeptide binding]; other site 483179005874 phosphorylation site [posttranslational modification] 483179005875 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483179005876 ATP binding site [chemical binding]; other site 483179005877 Mg2+ binding site [ion binding]; other site 483179005878 G-X-G motif; other site 483179005879 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 483179005880 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 483179005881 Phosphotransferase enzyme family; Region: APH; pfam01636 483179005882 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 483179005883 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 483179005884 Substrate binding site; other site 483179005885 metal-binding site 483179005886 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 483179005887 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 483179005888 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 483179005889 Part of AAA domain; Region: AAA_19; pfam13245 483179005890 Family description; Region: UvrD_C_2; pfam13538 483179005891 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 483179005892 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 483179005893 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 483179005894 catalytic residues [active] 483179005895 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 483179005896 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 483179005897 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 483179005898 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 483179005899 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 483179005900 substrate binding site [chemical binding]; other site 483179005901 active site 483179005902 catalytic residues [active] 483179005903 heterodimer interface [polypeptide binding]; other site 483179005904 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 483179005905 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 483179005906 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483179005907 catalytic residue [active] 483179005908 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 483179005909 active site 483179005910 Uncharacterized conserved protein [Function unknown]; Region: COG1434 483179005911 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 483179005912 putative active site [active] 483179005913 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 483179005914 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 483179005915 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 483179005916 benzoate transporter; Region: benE; TIGR00843 483179005917 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 483179005918 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 483179005919 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 483179005920 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 483179005921 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 483179005922 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 483179005923 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 483179005924 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 483179005925 23S rRNA binding site [nucleotide binding]; other site 483179005926 L21 binding site [polypeptide binding]; other site 483179005927 L13 binding site [polypeptide binding]; other site 483179005928 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 483179005929 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 483179005930 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 483179005931 dimer interface [polypeptide binding]; other site 483179005932 motif 1; other site 483179005933 active site 483179005934 motif 2; other site 483179005935 motif 3; other site 483179005936 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 483179005937 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 483179005938 putative tRNA-binding site [nucleotide binding]; other site 483179005939 B3/4 domain; Region: B3_4; pfam03483 483179005940 tRNA synthetase B5 domain; Region: B5; smart00874 483179005941 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 483179005942 dimer interface [polypeptide binding]; other site 483179005943 motif 1; other site 483179005944 motif 3; other site 483179005945 motif 2; other site 483179005946 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 483179005947 NAD-specific glutamate dehydrogenase; Region: NAD-GH; pfam10712 483179005948 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 483179005949 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 483179005950 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 483179005951 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 483179005952 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 483179005953 nucleotide binding site [chemical binding]; other site 483179005954 NEF interaction site [polypeptide binding]; other site 483179005955 SBD interface [polypeptide binding]; other site 483179005956 chaperone protein DnaJ; Provisional; Region: PRK10767 483179005957 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 483179005958 HSP70 interaction site [polypeptide binding]; other site 483179005959 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 483179005960 substrate binding site [polypeptide binding]; other site 483179005961 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 483179005962 Zn binding sites [ion binding]; other site 483179005963 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 483179005964 dimer interface [polypeptide binding]; other site 483179005965 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483179005966 S-adenosylmethionine binding site [chemical binding]; other site 483179005967 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 483179005968 active site 483179005969 dimer interface [polypeptide binding]; other site 483179005970 Uncharacterized conserved protein [Function unknown]; Region: COG5470 483179005971 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 483179005972 glutathione synthetase; Provisional; Region: PRK05246 483179005973 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 483179005974 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 483179005975 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 483179005976 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 483179005977 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483179005978 Walker A motif; other site 483179005979 ATP binding site [chemical binding]; other site 483179005980 Walker B motif; other site 483179005981 arginine finger; other site 483179005982 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 483179005983 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 483179005984 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 483179005985 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 483179005986 PBP superfamily domain; Region: PBP_like_2; pfam12849 483179005987 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 483179005988 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 483179005989 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179005990 dimer interface [polypeptide binding]; other site 483179005991 conserved gate region; other site 483179005992 putative PBP binding loops; other site 483179005993 ABC-ATPase subunit interface; other site 483179005994 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 483179005995 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 483179005996 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179005997 dimer interface [polypeptide binding]; other site 483179005998 conserved gate region; other site 483179005999 putative PBP binding loops; other site 483179006000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 483179006001 ABC-ATPase subunit interface; other site 483179006002 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 483179006003 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 483179006004 Walker A/P-loop; other site 483179006005 ATP binding site [chemical binding]; other site 483179006006 Q-loop/lid; other site 483179006007 ABC transporter signature motif; other site 483179006008 Walker B; other site 483179006009 D-loop; other site 483179006010 H-loop/switch region; other site 483179006011 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 483179006012 PhoU domain; Region: PhoU; pfam01895 483179006013 PhoU domain; Region: PhoU; pfam01895 483179006014 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 483179006015 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483179006016 active site 483179006017 phosphorylation site [posttranslational modification] 483179006018 intermolecular recognition site; other site 483179006019 dimerization interface [polypeptide binding]; other site 483179006020 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 483179006021 DNA binding site [nucleotide binding] 483179006022 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 483179006023 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 483179006024 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 483179006025 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 483179006026 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 483179006027 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 483179006028 dimerization interface [polypeptide binding]; other site 483179006029 DPS ferroxidase diiron center [ion binding]; other site 483179006030 ion pore; other site 483179006031 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 483179006032 Glycoprotease family; Region: Peptidase_M22; pfam00814 483179006033 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 483179006034 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 483179006035 Coenzyme A binding pocket [chemical binding]; other site 483179006036 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 483179006037 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 483179006038 putative acyl-acceptor binding pocket; other site 483179006039 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 483179006040 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 483179006041 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 483179006042 FeS/SAM binding site; other site 483179006043 TRAM domain; Region: TRAM; cl01282 483179006044 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 483179006045 PhoH-like protein; Region: PhoH; pfam02562 483179006046 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 483179006047 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 483179006048 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 483179006049 Transporter associated domain; Region: CorC_HlyC; smart01091 483179006050 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 483179006051 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 483179006052 putative active site [active] 483179006053 catalytic triad [active] 483179006054 putative dimer interface [polypeptide binding]; other site 483179006055 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 483179006056 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 483179006057 non-specific DNA binding site [nucleotide binding]; other site 483179006058 salt bridge; other site 483179006059 sequence-specific DNA binding site [nucleotide binding]; other site 483179006060 S-adenosylmethionine synthetase; Validated; Region: PRK05250 483179006061 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 483179006062 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 483179006063 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 483179006064 Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only]; Region: COG0220 483179006065 ribosome maturation protein RimP; Reviewed; Region: PRK00092 483179006066 Sm and related proteins; Region: Sm_like; cl00259 483179006067 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 483179006068 putative oligomer interface [polypeptide binding]; other site 483179006069 putative RNA binding site [nucleotide binding]; other site 483179006070 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 483179006071 NusA N-terminal domain; Region: NusA_N; pfam08529 483179006072 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 483179006073 RNA binding site [nucleotide binding]; other site 483179006074 homodimer interface [polypeptide binding]; other site 483179006075 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 483179006076 G-X-X-G motif; other site 483179006077 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 483179006078 G-X-X-G motif; other site 483179006079 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 483179006080 hypothetical protein; Provisional; Region: PRK09190 483179006081 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 483179006082 putative RNA binding cleft [nucleotide binding]; other site 483179006083 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 483179006084 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 483179006085 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 483179006086 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 483179006087 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 483179006088 G1 box; other site 483179006089 putative GEF interaction site [polypeptide binding]; other site 483179006090 GTP/Mg2+ binding site [chemical binding]; other site 483179006091 Switch I region; other site 483179006092 G2 box; other site 483179006093 G3 box; other site 483179006094 Switch II region; other site 483179006095 G4 box; other site 483179006096 G5 box; other site 483179006097 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 483179006098 Translation-initiation factor 2; Region: IF-2; pfam11987 483179006099 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 483179006100 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 483179006101 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 483179006102 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 483179006103 RNA binding site [nucleotide binding]; other site 483179006104 active site 483179006105 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 483179006106 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 483179006107 16S/18S rRNA binding site [nucleotide binding]; other site 483179006108 S13e-L30e interaction site [polypeptide binding]; other site 483179006109 25S rRNA binding site [nucleotide binding]; other site 483179006110 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 483179006111 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 483179006112 RNase E interface [polypeptide binding]; other site 483179006113 trimer interface [polypeptide binding]; other site 483179006114 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 483179006115 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 483179006116 RNase E interface [polypeptide binding]; other site 483179006117 trimer interface [polypeptide binding]; other site 483179006118 active site 483179006119 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 483179006120 putative nucleic acid binding region [nucleotide binding]; other site 483179006121 G-X-X-G motif; other site 483179006122 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 483179006123 RNA binding site [nucleotide binding]; other site 483179006124 domain interface; other site 483179006125 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 483179006126 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483179006127 S-adenosylmethionine binding site [chemical binding]; other site 483179006128 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505 483179006129 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 483179006130 NAD binding site [chemical binding]; other site 483179006131 homotetramer interface [polypeptide binding]; other site 483179006132 homodimer interface [polypeptide binding]; other site 483179006133 substrate binding site [chemical binding]; other site 483179006134 active site 483179006135 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 483179006136 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 483179006137 dimer interface [polypeptide binding]; other site 483179006138 active site 483179006139 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 483179006140 active site 1 [active] 483179006141 dimer interface [polypeptide binding]; other site 483179006142 active site 2 [active] 483179006143 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 483179006144 metal binding site 2 [ion binding]; metal-binding site 483179006145 putative DNA binding helix; other site 483179006146 metal binding site 1 [ion binding]; metal-binding site 483179006147 dimer interface [polypeptide binding]; other site 483179006148 structural Zn2+ binding site [ion binding]; other site 483179006149 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 483179006150 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 483179006151 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 483179006152 Bacterial SH3 domain; Region: SH3_4; pfam06347 483179006153 Bacterial SH3 domain; Region: SH3_4; pfam06347 483179006154 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 483179006155 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 483179006156 dimerization interface [polypeptide binding]; other site 483179006157 ligand binding site [chemical binding]; other site 483179006158 NADP binding site [chemical binding]; other site 483179006159 catalytic site [active] 483179006160 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 483179006161 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 483179006162 NlpC/P60 family; Region: NLPC_P60; cl17555 483179006163 Transcriptional regulators [Transcription]; Region: MarR; COG1846 483179006164 MarR family; Region: MarR; pfam01047 483179006165 multifunctional aminopeptidase A; Provisional; Region: PRK00913 483179006166 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 483179006167 interface (dimer of trimers) [polypeptide binding]; other site 483179006168 Substrate-binding/catalytic site; other site 483179006169 Zn-binding sites [ion binding]; other site 483179006170 Flp/Fap pilin component; Region: Flp_Fap; cl01585 483179006171 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 483179006172 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 483179006173 DNA binding site [nucleotide binding] 483179006174 catalytic residue [active] 483179006175 H2TH interface [polypeptide binding]; other site 483179006176 putative catalytic residues [active] 483179006177 turnover-facilitating residue; other site 483179006178 intercalation triad [nucleotide binding]; other site 483179006179 8OG recognition residue [nucleotide binding]; other site 483179006180 putative reading head residues; other site 483179006181 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 483179006182 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 483179006183 enoyl-CoA hydratase; Provisional; Region: PRK05862 483179006184 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 483179006185 substrate binding site [chemical binding]; other site 483179006186 oxyanion hole (OAH) forming residues; other site 483179006187 trimer interface [polypeptide binding]; other site 483179006188 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 483179006189 S-element; BCAN_B0002 483179006190 replication initiation protein RepC; Provisional; Region: PRK13824 483179006191 Replication protein C N-terminal domain; Region: RP-C; pfam03428 483179006192 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 483179006193 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 483179006194 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 483179006195 substrate binding site [chemical binding]; other site 483179006196 dimer interface [polypeptide binding]; other site 483179006197 ATP binding site [chemical binding]; other site 483179006198 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 483179006199 active site 483179006200 tetramer interface [polypeptide binding]; other site 483179006201 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 483179006202 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 483179006203 TM-ABC transporter signature motif; other site 483179006204 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 483179006205 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 483179006206 ligand binding site [chemical binding]; other site 483179006207 Predicted secreted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5664 483179006208 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 483179006209 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 483179006210 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 483179006211 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 483179006212 putative NAD(P) binding site [chemical binding]; other site 483179006213 active site 483179006214 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 483179006215 hydrophobic substrate binding pocket; other site 483179006216 Isochorismatase family; Region: Isochorismatase; pfam00857 483179006217 active site 483179006218 conserved cis-peptide bond; other site 483179006219 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 483179006220 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 483179006221 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 483179006222 acyl-activating enzyme (AAE) consensus motif; other site 483179006223 active site 483179006224 AMP binding site [chemical binding]; other site 483179006225 substrate binding site [chemical binding]; other site 483179006226 Condensation domain; Region: Condensation; pfam00668 483179006227 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 483179006228 bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108 483179006229 Moco binding site; other site 483179006230 metal coordination site [ion binding]; other site 483179006231 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 483179006232 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 483179006233 pentapeptide MXKDX repeat protein; Region: penta_MxKDx; TIGR02953 483179006234 RNA polymerase sigma factor; Provisional; Region: PRK12539 483179006235 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 483179006236 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 483179006237 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4944 483179006238 Transcriptional regulators [Transcription]; Region: FadR; COG2186 483179006239 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 483179006240 DNA-binding site [nucleotide binding]; DNA binding site 483179006241 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 483179006242 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 483179006243 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 483179006244 putative ligand binding site [chemical binding]; other site 483179006245 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 483179006246 TM-ABC transporter signature motif; other site 483179006247 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 483179006248 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 483179006249 TM-ABC transporter signature motif; other site 483179006250 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 483179006251 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 483179006252 Walker A/P-loop; other site 483179006253 ATP binding site [chemical binding]; other site 483179006254 Q-loop/lid; other site 483179006255 ABC transporter signature motif; other site 483179006256 Walker B; other site 483179006257 D-loop; other site 483179006258 H-loop/switch region; other site 483179006259 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 483179006260 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 483179006261 active site 483179006262 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 483179006263 classical (c) SDRs; Region: SDR_c; cd05233 483179006264 NAD(P) binding site [chemical binding]; other site 483179006265 active site 483179006266 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 483179006267 classical (c) SDRs; Region: SDR_c; cd05233 483179006268 NAD(P) binding site [chemical binding]; other site 483179006269 active site 483179006270 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 483179006271 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 483179006272 tetramer interface [polypeptide binding]; other site 483179006273 TPP-binding site [chemical binding]; other site 483179006274 heterodimer interface [polypeptide binding]; other site 483179006275 phosphorylation loop region [posttranslational modification] 483179006276 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 483179006277 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 483179006278 alpha subunit interface [polypeptide binding]; other site 483179006279 TPP binding site [chemical binding]; other site 483179006280 heterodimer interface [polypeptide binding]; other site 483179006281 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 483179006282 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 483179006283 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 483179006284 E3 interaction surface; other site 483179006285 lipoyl attachment site [posttranslational modification]; other site 483179006286 e3 binding domain; Region: E3_binding; pfam02817 483179006287 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 483179006288 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 483179006289 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 483179006290 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 483179006291 shikimate binding site; other site 483179006292 NAD(P) binding site [chemical binding]; other site 483179006293 magnesium-transporting ATPase; Provisional; Region: PRK15122 483179006294 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 483179006295 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 483179006296 Soluble P-type ATPase [General function prediction only]; Region: COG4087 483179006297 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 483179006298 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 483179006299 MgtC family; Region: MgtC; pfam02308 483179006300 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483179006301 ATP binding site [chemical binding]; other site 483179006302 Mg2+ binding site [ion binding]; other site 483179006303 G-X-G motif; other site 483179006304 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 483179006305 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483179006306 active site 483179006307 phosphorylation site [posttranslational modification] 483179006308 intermolecular recognition site; other site 483179006309 dimerization interface [polypeptide binding]; other site 483179006310 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 483179006311 dimerization interface [polypeptide binding]; other site 483179006312 DNA binding residues [nucleotide binding] 483179006313 Response regulator receiver domain; Region: Response_reg; pfam00072 483179006314 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483179006315 active site 483179006316 phosphorylation site [posttranslational modification] 483179006317 intermolecular recognition site; other site 483179006318 dimerization interface [polypeptide binding]; other site 483179006319 N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: HutG; COG3741 483179006320 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 483179006321 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 483179006322 active site 483179006323 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 483179006324 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 483179006325 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 483179006326 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 483179006327 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 483179006328 putative dimer interface [polypeptide binding]; other site 483179006329 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 483179006330 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 483179006331 tetramer interface [polypeptide binding]; other site 483179006332 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483179006333 catalytic residue [active] 483179006334 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 483179006335 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 483179006336 active site 483179006337 dimer interface [polypeptide binding]; other site 483179006338 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 483179006339 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 483179006340 active site 483179006341 FMN binding site [chemical binding]; other site 483179006342 substrate binding site [chemical binding]; other site 483179006343 3Fe-4S cluster binding site [ion binding]; other site 483179006344 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 483179006345 domain interface; other site 483179006346 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 483179006347 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 483179006348 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 483179006349 active site 483179006350 catalytic triad [active] 483179006351 oxyanion hole [active] 483179006352 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 483179006353 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 483179006354 ligand binding site [chemical binding]; other site 483179006355 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 483179006356 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 483179006357 ATP binding site [chemical binding]; other site 483179006358 Walker A motif; other site 483179006359 hexamer interface [polypeptide binding]; other site 483179006360 Walker B motif; other site 483179006361 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 483179006362 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 483179006363 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 483179006364 VirB7 interaction site; other site 483179006365 Type IV secretory pathway, component VirB8 [Intracellular trafficking and secretion]; Region: VirB8; COG3736 483179006366 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 483179006367 Type IV secretory pathway, VirB6 components [Intracellular trafficking and secretion]; Region: VirB6; COG3704 483179006368 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 483179006369 Type IV secretion system proteins; Region: T4SS; pfam07996 483179006370 Type IV secretory pathway, VirB4 components [Intracellular trafficking and secretion]; Region: VirB4; COG3451 483179006371 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 483179006372 Type IV secretory pathway, VirB3 components [Intracellular trafficking and secretion]; Region: VirB3; COG3702 483179006373 TrbC/VIRB2 family; Region: TrbC; pfam04956 483179006374 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 483179006375 N-acetyl-D-glucosamine binding site [chemical binding]; other site 483179006376 catalytic residue [active] 483179006377 lytic murein transglycosylase; Region: MltB_2; TIGR02283 483179006378 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 483179006379 N-acetyl-D-glucosamine binding site [chemical binding]; other site 483179006380 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 483179006381 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 483179006382 active site 483179006383 tetramer interface; other site 483179006384 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5338 483179006385 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 483179006386 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 483179006387 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 483179006388 putative active site [active] 483179006389 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 483179006390 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 483179006391 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 483179006392 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 483179006393 ferrochelatase; Reviewed; Region: hemH; PRK00035 483179006394 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 483179006395 C-terminal domain interface [polypeptide binding]; other site 483179006396 active site 483179006397 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 483179006398 active site 483179006399 N-terminal domain interface [polypeptide binding]; other site 483179006400 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 483179006401 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 483179006402 hypothetical protein; Provisional; Region: PRK07546 483179006403 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 483179006404 substrate-cofactor binding pocket; other site 483179006405 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483179006406 homodimer interface [polypeptide binding]; other site 483179006407 catalytic residue [active] 483179006408 aminodeoxychorismate synthase; Provisional; Region: PRK07508 483179006409 chorismate binding enzyme; Region: Chorismate_bind; cl10555 483179006410 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 483179006411 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 483179006412 active site 483179006413 Zn binding site [ion binding]; other site 483179006414 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 483179006415 Bacterial protein of unknown function (DUF882); Region: Peptidase_M15_2; pfam05951 483179006416 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 483179006417 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 483179006418 active site 483179006419 intersubunit interface [polypeptide binding]; other site 483179006420 catalytic residue [active] 483179006421 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 483179006422 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 483179006423 active site residue [active] 483179006424 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 483179006425 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 483179006426 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179006427 dimer interface [polypeptide binding]; other site 483179006428 conserved gate region; other site 483179006429 putative PBP binding loops; other site 483179006430 ABC-ATPase subunit interface; other site 483179006431 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 483179006432 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483179006433 Walker A/P-loop; other site 483179006434 ATP binding site [chemical binding]; other site 483179006435 Q-loop/lid; other site 483179006436 ABC transporter signature motif; other site 483179006437 Walker B; other site 483179006438 D-loop; other site 483179006439 H-loop/switch region; other site 483179006440 TOBE domain; Region: TOBE; cl01440 483179006441 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 483179006442 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 483179006443 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 483179006444 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 483179006445 LysR family transcriptional regulator; Provisional; Region: PRK14997 483179006446 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 483179006447 putative effector binding pocket; other site 483179006448 dimerization interface [polypeptide binding]; other site 483179006449 amidase; Provisional; Region: PRK08310 483179006450 indole-3-acetamide amidohydrolase; Region: PLN02722 483179006451 speF leader; BCAN_B0103 483179006452 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 483179006453 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 483179006454 dimer interface [polypeptide binding]; other site 483179006455 active site 483179006456 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 483179006457 catalytic residues [active] 483179006458 substrate binding site [chemical binding]; other site 483179006459 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 483179006460 Chain length determinant protein; Region: Wzz; pfam02706 483179006461 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 483179006462 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 483179006463 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 483179006464 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 483179006465 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 483179006466 active site 483179006467 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 483179006468 O-Antigen ligase; Region: Wzy_C; pfam04932 483179006469 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 483179006470 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 483179006471 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 483179006472 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 483179006473 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 483179006474 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG0362 483179006475 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 483179006476 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 483179006477 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 483179006478 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483179006479 Walker A/P-loop; other site 483179006480 ATP binding site [chemical binding]; other site 483179006481 Q-loop/lid; other site 483179006482 ABC transporter signature motif; other site 483179006483 Walker B; other site 483179006484 D-loop; other site 483179006485 H-loop/switch region; other site 483179006486 TOBE domain; Region: TOBE_2; pfam08402 483179006487 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 483179006488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179006489 dimer interface [polypeptide binding]; other site 483179006490 conserved gate region; other site 483179006491 putative PBP binding loops; other site 483179006492 ABC-ATPase subunit interface; other site 483179006493 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179006494 dimer interface [polypeptide binding]; other site 483179006495 conserved gate region; other site 483179006496 putative PBP binding loops; other site 483179006497 ABC-ATPase subunit interface; other site 483179006498 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 483179006499 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 483179006500 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 483179006501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483179006502 putative substrate translocation pore; other site 483179006503 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483179006504 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 483179006505 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 483179006506 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 483179006507 Autoinducer binding domain; Region: Autoind_bind; pfam03472 483179006508 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 483179006509 DNA binding residues [nucleotide binding] 483179006510 dimerization interface [polypeptide binding]; other site 483179006511 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377 483179006512 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 483179006513 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 483179006514 Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868 483179006515 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 483179006516 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 483179006517 flagellar motor protein MotA; Validated; Region: PRK09110 483179006518 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 483179006519 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 483179006520 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642 483179006521 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 483179006522 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 483179006523 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002 483179006524 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 483179006525 Walker A motif; other site 483179006526 ATP binding site [chemical binding]; other site 483179006527 Walker B motif; other site 483179006528 PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389 483179006529 active site 483179006530 GtrA-like protein; Region: GtrA; pfam04138 483179006531 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 483179006532 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 483179006533 Ligand binding site; other site 483179006534 Putative Catalytic site; other site 483179006535 DXD motif; other site 483179006536 Peptidase family M48; Region: Peptidase_M48; cl12018 483179006537 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 483179006538 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 483179006539 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 483179006540 Helix-turn-helix domain; Region: HTH_18; pfam12833 483179006541 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 483179006542 Transposase; Region: HTH_Tnp_1; cl17663 483179006543 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483179006544 D-galactonate transporter; Region: 2A0114; TIGR00893 483179006545 putative substrate translocation pore; other site 483179006546 putative aldolase; Validated; Region: PRK08130 483179006547 intersubunit interface [polypeptide binding]; other site 483179006548 active site 483179006549 Zn2+ binding site [ion binding]; other site 483179006550 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 483179006551 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 483179006552 putative NAD(P) binding site [chemical binding]; other site 483179006553 active site 483179006554 putative substrate binding site [chemical binding]; other site 483179006555 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 483179006556 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 483179006557 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 483179006558 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 483179006559 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 483179006560 Metal-binding active site; metal-binding site 483179006561 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 483179006562 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003 483179006563 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782 483179006564 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 483179006565 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 483179006566 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790 483179006567 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 483179006568 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 483179006569 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK06005 483179006570 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 483179006571 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 483179006572 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 483179006573 Uncharacterized conserved protein [Function unknown]; Region: COG3334 483179006574 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 483179006575 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 483179006576 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 483179006577 FliP family; Region: FliP; cl00593 483179006578 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 483179006579 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4893 483179006580 Transcriptional regulator [Transcription]; Region: LysR; COG0583 483179006581 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 483179006582 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 483179006583 putative dimerization interface [polypeptide binding]; other site 483179006584 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 483179006585 CoA-transferase family III; Region: CoA_transf_3; pfam02515 483179006586 Uncharacterized conserved protein [Function unknown]; Region: COG3777 483179006587 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 483179006588 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 483179006589 active site 2 [active] 483179006590 active site 1 [active] 483179006591 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 483179006592 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 483179006593 Cytochrome c2 [Energy production and conversion]; Region: COG3474 483179006594 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841 483179006595 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 483179006596 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 483179006597 DNA-binding site [nucleotide binding]; DNA binding site 483179006598 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 483179006599 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 483179006600 transcriptional activator TtdR; Provisional; Region: PRK09801 483179006601 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 483179006602 putative effector binding pocket; other site 483179006603 dimerization interface [polypeptide binding]; other site 483179006604 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 483179006605 FAD binding domain; Region: FAD_binding_4; pfam01565 483179006606 FAD binding domain; Region: FAD_binding_4; pfam01565 483179006607 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 483179006608 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 483179006609 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 483179006610 Cysteine-rich domain; Region: CCG; pfam02754 483179006611 Cysteine-rich domain; Region: CCG; pfam02754 483179006612 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 483179006613 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 483179006614 active site 483179006615 catalytic tetrad [active] 483179006616 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 483179006617 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 483179006618 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 483179006619 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 483179006620 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 483179006621 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 483179006622 dimer interface [polypeptide binding]; other site 483179006623 motif 1; other site 483179006624 motif 2; other site 483179006625 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 483179006626 active site 483179006627 motif 3; other site 483179006628 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 483179006629 anticodon binding site; other site 483179006630 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295 483179006631 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 483179006632 motif 1; other site 483179006633 dimer interface [polypeptide binding]; other site 483179006634 active site 483179006635 motif 2; other site 483179006636 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 483179006637 active site 483179006638 motif 3; other site 483179006639 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583 483179006640 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 483179006641 Predicted membrane protein [Function unknown]; Region: COG2259 483179006642 fumarate hydratase; Reviewed; Region: fumC; PRK00485 483179006643 Class II fumarases; Region: Fumarase_classII; cd01362 483179006644 active site 483179006645 tetramer interface [polypeptide binding]; other site 483179006646 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 483179006647 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 483179006648 ring oligomerisation interface [polypeptide binding]; other site 483179006649 ATP/Mg binding site [chemical binding]; other site 483179006650 stacking interactions; other site 483179006651 hinge regions; other site 483179006652 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 483179006653 oligomerisation interface [polypeptide binding]; other site 483179006654 mobile loop; other site 483179006655 roof hairpin; other site 483179006656 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 483179006657 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 483179006658 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 483179006659 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 483179006660 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 483179006661 active site 483179006662 Riboflavin kinase; Region: Flavokinase; smart00904 483179006663 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 483179006664 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 483179006665 active site 483179006666 HIGH motif; other site 483179006667 nucleotide binding site [chemical binding]; other site 483179006668 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 483179006669 active site 483179006670 KMSKS motif; other site 483179006671 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 483179006672 tRNA binding surface [nucleotide binding]; other site 483179006673 anticodon binding site; other site 483179006674 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 483179006675 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 483179006676 nucleoside/Zn binding site; other site 483179006677 dimer interface [polypeptide binding]; other site 483179006678 catalytic motif [active] 483179006679 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 483179006680 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 483179006681 RNA binding surface [nucleotide binding]; other site 483179006682 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 483179006683 active site 483179006684 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 483179006685 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483179006686 S-adenosylmethionine binding site [chemical binding]; other site 483179006687 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 483179006688 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 483179006689 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 483179006690 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 483179006691 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 483179006692 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 483179006693 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 483179006694 TrkA-N domain; Region: TrkA_N; pfam02254 483179006695 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 483179006696 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 483179006697 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 483179006698 active site 483179006699 Domain of unknown function (DUF4170); Region: DUF4170; pfam13773 483179006700 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 483179006701 putative acyl-acceptor binding pocket; other site 483179006702 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 483179006703 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 483179006704 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 483179006705 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 483179006706 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 483179006707 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3908 483179006708 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 483179006709 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483179006710 ATP binding site [chemical binding]; other site 483179006711 Mg2+ binding site [ion binding]; other site 483179006712 G-X-G motif; other site 483179006713 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 483179006714 ATP binding site [chemical binding]; other site 483179006715 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 483179006716 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 483179006717 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 483179006718 active site 483179006719 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 483179006720 Transcriptional regulator [Transcription]; Region: IclR; COG1414 483179006721 Bacterial transcriptional regulator; Region: IclR; pfam01614 483179006722 enoyl-CoA hydratase; Provisional; Region: PRK08138 483179006723 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 483179006724 substrate binding site [chemical binding]; other site 483179006725 oxyanion hole (OAH) forming residues; other site 483179006726 trimer interface [polypeptide binding]; other site 483179006727 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 483179006728 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 483179006729 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 483179006730 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 483179006731 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 483179006732 CoA-transferase family III; Region: CoA_transf_3; pfam02515 483179006733 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 483179006734 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 483179006735 putative active site [active] 483179006736 putative FMN binding site [chemical binding]; other site 483179006737 putative substrate binding site [chemical binding]; other site 483179006738 putative catalytic residue [active] 483179006739 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg7; cd04786 483179006740 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 483179006741 DNA binding residues [nucleotide binding] 483179006742 putative dimer interface [polypeptide binding]; other site 483179006743 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 483179006744 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 483179006745 potential catalytic triad [active] 483179006746 conserved cys residue [active] 483179006747 sensor protein QseC; Provisional; Region: PRK10337 483179006748 HAMP domain; Region: HAMP; pfam00672 483179006749 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483179006750 dimer interface [polypeptide binding]; other site 483179006751 phosphorylation site [posttranslational modification] 483179006752 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483179006753 Mg2+ binding site [ion binding]; other site 483179006754 G-X-G motif; other site 483179006755 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 483179006756 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 483179006757 DNA binding site [nucleotide binding] 483179006758 Uncharacterized conserved protein [Function unknown]; Region: COG5591 483179006759 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 483179006760 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 483179006761 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 483179006762 Flavodoxin; Region: Flavodoxin_1; pfam00258 483179006763 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like2; cd06201 483179006764 FAD binding pocket [chemical binding]; other site 483179006765 FAD binding motif [chemical binding]; other site 483179006766 catalytic residues [active] 483179006767 NAD binding pocket [chemical binding]; other site 483179006768 phosphate binding motif [ion binding]; other site 483179006769 beta-alpha-beta structure motif; other site 483179006770 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 483179006771 ApbE family; Region: ApbE; pfam02424 483179006772 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 483179006773 GAF domain; Region: GAF; pfam01590 483179006774 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 483179006775 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 483179006776 metal binding site [ion binding]; metal-binding site 483179006777 active site 483179006778 I-site; other site 483179006779 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 483179006780 EamA-like transporter family; Region: EamA; pfam00892 483179006781 EamA-like transporter family; Region: EamA; cl17759 483179006782 Transcriptional regulators [Transcription]; Region: GntR; COG1802 483179006783 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 483179006784 DNA-binding site [nucleotide binding]; DNA binding site 483179006785 FCD domain; Region: FCD; pfam07729 483179006786 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 483179006787 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 483179006788 inhibitor site; inhibition site 483179006789 active site 483179006790 dimer interface [polypeptide binding]; other site 483179006791 catalytic residue [active] 483179006792 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 483179006793 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 483179006794 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 483179006795 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 483179006796 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 483179006797 Cytochrome c; Region: Cytochrom_C; pfam00034 483179006798 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 483179006799 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 483179006800 Binuclear center (active site) [active] 483179006801 K-pathway; other site 483179006802 Putative proton exit pathway; other site 483179006803 MoxR-like ATPases [General function prediction only]; Region: COG0714 483179006804 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483179006805 Walker A motif; other site 483179006806 ATP binding site [chemical binding]; other site 483179006807 Walker B motif; other site 483179006808 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 483179006809 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 483179006810 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 483179006811 metal ion-dependent adhesion site (MIDAS); other site 483179006812 Uncharacterized conserved protein [Function unknown]; Region: COG4309 483179006813 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 483179006814 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 483179006815 CPxP motif; other site 483179006816 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 483179006817 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 483179006818 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 483179006819 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 483179006820 nucleophilic elbow; other site 483179006821 catalytic triad; other site 483179006822 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 483179006823 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 483179006824 Multicopper oxidase; Region: Cu-oxidase; pfam00394 483179006825 Uncharacterized conserved protein [Function unknown]; Region: COG1262 483179006826 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 483179006827 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 483179006828 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 483179006829 ligand binding site [chemical binding]; other site 483179006830 flexible hinge region; other site 483179006831 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 483179006832 putative switch regulator; other site 483179006833 non-specific DNA interactions [nucleotide binding]; other site 483179006834 DNA binding site [nucleotide binding] 483179006835 sequence specific DNA binding site [nucleotide binding]; other site 483179006836 putative cAMP binding site [chemical binding]; other site 483179006837 Transcriptional regulators [Transcription]; Region: PurR; COG1609 483179006838 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 483179006839 DNA binding site [nucleotide binding] 483179006840 domain linker motif; other site 483179006841 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 483179006842 dimerization interface [polypeptide binding]; other site 483179006843 ligand binding site [chemical binding]; other site 483179006844 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 483179006845 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 483179006846 putative ligand binding site [chemical binding]; other site 483179006847 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 483179006848 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483179006849 Walker A/P-loop; other site 483179006850 ATP binding site [chemical binding]; other site 483179006851 Q-loop/lid; other site 483179006852 ABC transporter signature motif; other site 483179006853 Walker B; other site 483179006854 D-loop; other site 483179006855 H-loop/switch region; other site 483179006856 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 483179006857 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 483179006858 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 483179006859 TM-ABC transporter signature motif; other site 483179006860 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 483179006861 classical (c) SDRs; Region: SDR_c; cd05233 483179006862 NAD(P) binding site [chemical binding]; other site 483179006863 active site 483179006864 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 483179006865 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 483179006866 N- and C-terminal domain interface [polypeptide binding]; other site 483179006867 active site 483179006868 MgATP binding site [chemical binding]; other site 483179006869 catalytic site [active] 483179006870 metal binding site [ion binding]; metal-binding site 483179006871 carbohydrate binding site [chemical binding]; other site 483179006872 putative homodimer interface [polypeptide binding]; other site 483179006873 RES domain; Region: RES; smart00953 483179006874 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 483179006875 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 483179006876 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 483179006877 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 483179006878 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 483179006879 ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163 483179006880 4Fe-4S binding domain; Region: Fer4_5; pfam12801 483179006881 4Fe-4S binding domain; Region: Fer4_5; pfam12801 483179006882 nitrous-oxide reductase; Validated; Region: PRK02888 483179006883 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 483179006884 Nitrous oxidase accessory protein [Inorganic ion transport and metabolism]; Region: NosD; COG3420 483179006885 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 483179006886 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 483179006887 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 483179006888 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 483179006889 Walker A/P-loop; other site 483179006890 ATP binding site [chemical binding]; other site 483179006891 Q-loop/lid; other site 483179006892 ABC transporter signature motif; other site 483179006893 Walker B; other site 483179006894 D-loop; other site 483179006895 H-loop/switch region; other site 483179006896 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 483179006897 Predicted lipoprotein involved in nitrous oxide reduction [Energy production and conversion]; Region: NosL; COG4314 483179006898 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 483179006899 ApbE family; Region: ApbE; pfam02424 483179006900 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 483179006901 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 483179006902 ligand binding site [chemical binding]; other site 483179006903 flexible hinge region; other site 483179006904 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 483179006905 putative switch regulator; other site 483179006906 non-specific DNA interactions [nucleotide binding]; other site 483179006907 DNA binding site [nucleotide binding] 483179006908 sequence specific DNA binding site [nucleotide binding]; other site 483179006909 putative cAMP binding site [chemical binding]; other site 483179006910 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 483179006911 pseudoazurin; Region: pseudoazurin; TIGR02375 483179006912 Uncharacterized protein involved in response to NO [Inorganic ion transport and metabolism]; Region: NnrS; COG3213 483179006913 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 483179006914 NMT1-like family; Region: NMT1_2; pfam13379 483179006915 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 483179006916 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179006917 dimer interface [polypeptide binding]; other site 483179006918 conserved gate region; other site 483179006919 putative PBP binding loops; other site 483179006920 ABC-ATPase subunit interface; other site 483179006921 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 483179006922 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 483179006923 Walker A/P-loop; other site 483179006924 ATP binding site [chemical binding]; other site 483179006925 Q-loop/lid; other site 483179006926 ABC transporter signature motif; other site 483179006927 Walker B; other site 483179006928 D-loop; other site 483179006929 H-loop/switch region; other site 483179006930 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 483179006931 putative protease; Provisional; Region: PRK15447 483179006932 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 483179006933 Peptidase family U32; Region: Peptidase_U32; pfam01136 483179006934 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 483179006935 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 483179006936 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 483179006937 Flavoprotein; Region: Flavoprotein; pfam02441 483179006938 Protein of unknown function (DUF2478); Region: DUF2478; pfam10649 483179006939 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 483179006940 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 483179006941 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 483179006942 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 483179006943 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 483179006944 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 483179006945 [4Fe-4S] binding site [ion binding]; other site 483179006946 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 483179006947 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 483179006948 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 483179006949 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 483179006950 molybdopterin cofactor binding site; other site 483179006951 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 483179006952 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483179006953 putative substrate translocation pore; other site 483179006954 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 483179006955 transcriptional activator FtrB; Provisional; Region: ftrB; PRK09392 483179006956 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 483179006957 ligand binding site [chemical binding]; other site 483179006958 flexible hinge region; other site 483179006959 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 483179006960 Transcriptional regulators [Transcription]; Region: PurR; COG1609 483179006961 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 483179006962 DNA binding site [nucleotide binding] 483179006963 domain linker motif; other site 483179006964 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 483179006965 ligand binding site [chemical binding]; other site 483179006966 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 483179006967 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 483179006968 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 483179006969 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179006970 dimer interface [polypeptide binding]; other site 483179006971 conserved gate region; other site 483179006972 putative PBP binding loops; other site 483179006973 ABC-ATPase subunit interface; other site 483179006974 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 483179006975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179006976 dimer interface [polypeptide binding]; other site 483179006977 conserved gate region; other site 483179006978 putative PBP binding loops; other site 483179006979 ABC-ATPase subunit interface; other site 483179006980 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 483179006981 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 483179006982 Walker A/P-loop; other site 483179006983 ATP binding site [chemical binding]; other site 483179006984 Q-loop/lid; other site 483179006985 ABC transporter signature motif; other site 483179006986 Walker B; other site 483179006987 D-loop; other site 483179006988 H-loop/switch region; other site 483179006989 TOBE domain; Region: TOBE_2; pfam08402 483179006990 Trehalose utilization protein [Carbohydrate transport and metabolism]; Region: ThuA; COG4813 483179006991 conserved cys residue [active] 483179006992 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 483179006993 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 483179006994 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 483179006995 Transmembrane secretion effector; Region: MFS_3; pfam05977 483179006996 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483179006997 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483179006998 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 483179006999 catalytic residues [active] 483179007000 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 483179007001 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 483179007002 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 483179007003 Class I ribonucleotide reductase; Region: RNR_I; cd01679 483179007004 active site 483179007005 dimer interface [polypeptide binding]; other site 483179007006 catalytic residues [active] 483179007007 effector binding site; other site 483179007008 R2 peptide binding site; other site 483179007009 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 483179007010 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 483179007011 dimer interface [polypeptide binding]; other site 483179007012 putative radical transfer pathway; other site 483179007013 diiron center [ion binding]; other site 483179007014 tyrosyl radical; other site 483179007015 septum formation inhibitor; Reviewed; Region: minC; PRK05177 483179007016 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 483179007017 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 483179007018 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 483179007019 Switch I; other site 483179007020 Switch II; other site 483179007021 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 483179007022 Domain of unknown function (DUF3597); Region: DUF3597; pfam12200 483179007023 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 483179007024 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 483179007025 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 483179007026 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 483179007027 Walker A/P-loop; other site 483179007028 ATP binding site [chemical binding]; other site 483179007029 Q-loop/lid; other site 483179007030 ABC transporter signature motif; other site 483179007031 Walker B; other site 483179007032 D-loop; other site 483179007033 H-loop/switch region; other site 483179007034 TOBE domain; Region: TOBE_2; pfam08402 483179007035 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179007036 dimer interface [polypeptide binding]; other site 483179007037 conserved gate region; other site 483179007038 putative PBP binding loops; other site 483179007039 ABC-ATPase subunit interface; other site 483179007040 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 483179007041 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179007042 dimer interface [polypeptide binding]; other site 483179007043 conserved gate region; other site 483179007044 putative PBP binding loops; other site 483179007045 ABC-ATPase subunit interface; other site 483179007046 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 483179007047 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 483179007048 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 483179007049 HlyD family secretion protein; Region: HlyD_3; pfam13437 483179007050 Predicted membrane protein [Function unknown]; Region: COG4803 483179007051 glutaminase; Reviewed; Region: PRK12356 483179007052 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 483179007053 acid-resistance protein; Provisional; Region: PRK10208 483179007054 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 483179007055 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 483179007056 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 483179007057 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 483179007058 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 483179007059 LysR substrate binding domain; Region: LysR_substrate; pfam03466 483179007060 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 483179007061 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 483179007062 Substrate binding site; other site 483179007063 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 483179007064 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 483179007065 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 483179007066 active site 483179007067 substrate binding site [chemical binding]; other site 483179007068 metal binding site [ion binding]; metal-binding site 483179007069 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 483179007070 putative active site pocket [active] 483179007071 cleavage site 483179007072 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 483179007073 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 483179007074 putative ion selectivity filter; other site 483179007075 putative pore gating glutamate residue; other site 483179007076 putative H+/Cl- coupling transport residue; other site 483179007077 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 483179007078 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 483179007079 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 483179007080 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 483179007081 active site 483179007082 Cytochrome c [Energy production and conversion]; Region: COG3258 483179007083 Cytochrome c; Region: Cytochrom_C; pfam00034 483179007084 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 483179007085 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 483179007086 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 483179007087 dimerization interface [polypeptide binding]; other site 483179007088 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 483179007089 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 483179007090 tetramer interface [polypeptide binding]; other site 483179007091 heme binding pocket [chemical binding]; other site 483179007092 NADPH binding site [chemical binding]; other site 483179007093 Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495 483179007094 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 483179007095 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 483179007096 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 483179007097 CoenzymeA binding site [chemical binding]; other site 483179007098 subunit interaction site [polypeptide binding]; other site 483179007099 PHB binding site; other site 483179007100 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06026 483179007101 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, putative; Region: MTA/SAH-nuc-hyp; TIGR01705 483179007102 GMP synthase; Reviewed; Region: guaA; PRK00074 483179007103 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 483179007104 AMP/PPi binding site [chemical binding]; other site 483179007105 candidate oxyanion hole; other site 483179007106 catalytic triad [active] 483179007107 potential glutamine specificity residues [chemical binding]; other site 483179007108 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 483179007109 ATP Binding subdomain [chemical binding]; other site 483179007110 Ligand Binding sites [chemical binding]; other site 483179007111 Dimerization subdomain; other site 483179007112 integrase; Provisional; Region: PRK09692 483179007113 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 483179007114 active site 483179007115 Int/Topo IB signature motif; other site 483179007116 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 483179007117 Replication initiator protein A; Region: RPA; pfam10134 483179007118 P-type conjugative transfer protein TrbL; Region: TrbL_P; TIGR02783 483179007119 P-type conjugative transfer protein TrbJ; Region: TrbJ_Ti; TIGR02780 483179007120 TraC-like protein; Region: TraC; cl06725 483179007121 conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877 483179007122 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 483179007123 conjugal transfer relaxase TraI; Provisional; Region: PRK13878 483179007124 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 483179007125 Predicted ATPase [General function prediction only]; Region: COG5293 483179007126 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 483179007127 DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077 483179007128 Uncharacterized protein probably involved in high-affinity Fe2+ transport [Inorganic ion transport and metabolism]; Region: Tpd; COG3470 483179007129 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 483179007130 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 483179007131 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 483179007132 4Fe-4S binding domain; Region: Fer4_5; pfam12801 483179007133 putative phosphoketolase; Provisional; Region: PRK05261 483179007134 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 483179007135 TPP-binding site; other site 483179007136 XFP C-terminal domain; Region: XFP_C; pfam09363 483179007137 acetate kinase; Provisional; Region: PRK07058 483179007138 propionate/acetate kinase; Provisional; Region: PRK12379 483179007139 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 483179007140 Cytochrome P450; Region: p450; cl12078 483179007141 Transcriptional regulators [Transcription]; Region: GntR; COG1802 483179007142 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 483179007143 DNA-binding site [nucleotide binding]; DNA binding site 483179007144 FCD domain; Region: FCD; pfam07729 483179007145 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 483179007146 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 483179007147 NAD(P) binding site [chemical binding]; other site 483179007148 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 483179007149 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 483179007150 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 483179007151 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 483179007152 TM-ABC transporter signature motif; other site 483179007153 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 483179007154 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 483179007155 Walker A/P-loop; other site 483179007156 ATP binding site [chemical binding]; other site 483179007157 Q-loop/lid; other site 483179007158 ABC transporter signature motif; other site 483179007159 Walker B; other site 483179007160 D-loop; other site 483179007161 H-loop/switch region; other site 483179007162 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 483179007163 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483179007164 NAD(P) binding site [chemical binding]; other site 483179007165 active site 483179007166 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 483179007167 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 483179007168 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 483179007169 shikimate binding site; other site 483179007170 NAD(P) binding site [chemical binding]; other site 483179007171 choline dehydrogenase; Validated; Region: PRK02106 483179007172 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 483179007173 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 483179007174 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 483179007175 tetramerization interface [polypeptide binding]; other site 483179007176 NAD(P) binding site [chemical binding]; other site 483179007177 catalytic residues [active] 483179007178 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 483179007179 Zinc-dependent alcohol dehydrogenases (ADH) and class III ADG (AKA formaldehyde dehydrogenase); Region: liver_ADH_like1; cd08281 483179007180 NAD binding site [chemical binding]; other site 483179007181 catalytic Zn binding site [ion binding]; other site 483179007182 substrate binding site [chemical binding]; other site 483179007183 structural Zn binding site [ion binding]; other site 483179007184 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 483179007185 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 483179007186 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 483179007187 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 483179007188 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 483179007189 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 483179007190 Walker A/P-loop; other site 483179007191 ATP binding site [chemical binding]; other site 483179007192 Q-loop/lid; other site 483179007193 ABC transporter signature motif; other site 483179007194 Walker B; other site 483179007195 D-loop; other site 483179007196 H-loop/switch region; other site 483179007197 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 483179007198 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 483179007199 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 483179007200 Walker A/P-loop; other site 483179007201 ATP binding site [chemical binding]; other site 483179007202 Q-loop/lid; other site 483179007203 ABC transporter signature motif; other site 483179007204 Walker B; other site 483179007205 D-loop; other site 483179007206 H-loop/switch region; other site 483179007207 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 483179007208 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 483179007209 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 483179007210 inhibitor site; inhibition site 483179007211 active site 483179007212 dimer interface [polypeptide binding]; other site 483179007213 catalytic residue [active] 483179007214 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 483179007215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179007216 dimer interface [polypeptide binding]; other site 483179007217 conserved gate region; other site 483179007218 putative PBP binding loops; other site 483179007219 ABC-ATPase subunit interface; other site 483179007220 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 483179007221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179007222 dimer interface [polypeptide binding]; other site 483179007223 conserved gate region; other site 483179007224 putative PBP binding loops; other site 483179007225 ABC-ATPase subunit interface; other site 483179007226 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 483179007227 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 483179007228 Transcriptional regulators [Transcription]; Region: FadR; COG2186 483179007229 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 483179007230 DNA-binding site [nucleotide binding]; DNA binding site 483179007231 FCD domain; Region: FCD; pfam07729 483179007232 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 483179007233 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 483179007234 putative active site cavity [active] 483179007235 N-acetylmannosamine kinase; Provisional; Region: PRK05082 483179007236 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 483179007237 nucleotide binding site [chemical binding]; other site 483179007238 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 483179007239 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 483179007240 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 483179007241 ligand binding site [chemical binding]; other site 483179007242 flexible hinge region; other site 483179007243 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 483179007244 putative switch regulator; other site 483179007245 non-specific DNA interactions [nucleotide binding]; other site 483179007246 DNA binding site [nucleotide binding] 483179007247 sequence specific DNA binding site [nucleotide binding]; other site 483179007248 putative cAMP binding site [chemical binding]; other site 483179007249 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 483179007250 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 483179007251 DNA binding residues [nucleotide binding] 483179007252 dimerization interface [polypeptide binding]; other site 483179007253 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 483179007254 Chain length determinant protein; Region: Wzz; cl15801 483179007255 AAA domain; Region: AAA_31; pfam13614 483179007256 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 483179007257 G3 box; other site 483179007258 Switch II region; other site 483179007259 G4 box; other site 483179007260 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 483179007261 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 483179007262 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 483179007263 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 483179007264 NADP binding site [chemical binding]; other site 483179007265 active site 483179007266 putative substrate binding site [chemical binding]; other site 483179007267 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 483179007268 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 483179007269 NADP-binding site; other site 483179007270 homotetramer interface [polypeptide binding]; other site 483179007271 substrate binding site [chemical binding]; other site 483179007272 homodimer interface [polypeptide binding]; other site 483179007273 active site 483179007274 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 483179007275 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 483179007276 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 483179007277 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 483179007278 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 483179007279 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 483179007280 putative ADP-binding pocket [chemical binding]; other site 483179007281 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 483179007282 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 483179007283 putative trimer interface [polypeptide binding]; other site 483179007284 putative active site [active] 483179007285 putative substrate binding site [chemical binding]; other site 483179007286 putative CoA binding site [chemical binding]; other site 483179007287 Uncharacterized conserved protein [Function unknown]; Region: COG1434 483179007288 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 483179007289 putative active site [active] 483179007290 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 483179007291 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 483179007292 putative metal binding site; other site 483179007293 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 483179007294 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 483179007295 Mg++ binding site [ion binding]; other site 483179007296 putative catalytic motif [active] 483179007297 substrate binding site [chemical binding]; other site 483179007298 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 483179007299 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 483179007300 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 483179007301 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 483179007302 active site 483179007303 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 483179007304 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 483179007305 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 483179007306 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 483179007307 glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209 483179007308 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 483179007309 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 483179007310 catalytic residue [active] 483179007311 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 483179007312 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 483179007313 extended (e) SDRs; Region: SDR_e; cd08946 483179007314 NAD(P) binding site [chemical binding]; other site 483179007315 active site 483179007316 substrate binding site [chemical binding]; other site 483179007317 Uncharacterized protein conserved in bacteria with an aminopeptidase-like domain [General function prediction only]; Region: COG4310 483179007318 M28 Zn-Peptidases; Region: M28_like_3; cd05644 483179007319 active site 483179007320 metal binding site [ion binding]; metal-binding site 483179007321 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 483179007322 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 483179007323 Methyltransferase domain; Region: Methyltransf_23; pfam13489 483179007324 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483179007325 S-adenosylmethionine binding site [chemical binding]; other site 483179007326 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 483179007327 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 483179007328 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 483179007329 active site 483179007330 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 483179007331 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 483179007332 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 483179007333 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 483179007334 N- and C-terminal domain interface [polypeptide binding]; other site 483179007335 active site 483179007336 MgATP binding site [chemical binding]; other site 483179007337 catalytic site [active] 483179007338 metal binding site [ion binding]; metal-binding site 483179007339 glycerol binding site [chemical binding]; other site 483179007340 homotetramer interface [polypeptide binding]; other site 483179007341 homodimer interface [polypeptide binding]; other site 483179007342 FBP binding site [chemical binding]; other site 483179007343 protein IIAGlc interface [polypeptide binding]; other site 483179007344 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483179007345 Major Facilitator Superfamily; Region: MFS_1; pfam07690 483179007346 putative substrate translocation pore; other site 483179007347 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 483179007348 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 483179007349 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 483179007350 putative dimerization interface [polypeptide binding]; other site 483179007351 putative substrate binding pocket [chemical binding]; other site 483179007352 methionine sulfoxide reductase B; Provisional; Region: PRK00222 483179007353 SelR domain; Region: SelR; pfam01641 483179007354 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 483179007355 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 483179007356 active site 483179007357 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 483179007358 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 483179007359 dimer interface [polypeptide binding]; other site 483179007360 active site 483179007361 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 483179007362 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 483179007363 NAD binding site [chemical binding]; other site 483179007364 homodimer interface [polypeptide binding]; other site 483179007365 homotetramer interface [polypeptide binding]; other site 483179007366 active site 483179007367 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 483179007368 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_2; cd05973 483179007369 active site 483179007370 acyl-activating enzyme (AAE) consensus motif; other site 483179007371 putative CoA binding site [chemical binding]; other site 483179007372 AMP binding site [chemical binding]; other site 483179007373 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 483179007374 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 483179007375 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 483179007376 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 483179007377 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 483179007378 ligand binding site [chemical binding]; other site 483179007379 NAD binding site [chemical binding]; other site 483179007380 tetramer interface [polypeptide binding]; other site 483179007381 catalytic site [active] 483179007382 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 483179007383 L-serine binding site [chemical binding]; other site 483179007384 ACT domain interface; other site 483179007385 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 483179007386 active site 483179007387 catalytic residues [active] 483179007388 metal binding site [ion binding]; metal-binding site 483179007389 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 483179007390 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 483179007391 dimerization interface [polypeptide binding]; other site 483179007392 putative DNA binding site [nucleotide binding]; other site 483179007393 putative Zn2+ binding site [ion binding]; other site 483179007394 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 483179007395 Predicted transporter component [General function prediction only]; Region: COG2391 483179007396 Predicted transporter component [General function prediction only]; Region: COG2391 483179007397 Sulphur transport; Region: Sulf_transp; pfam04143 483179007398 Transcriptional regulators [Transcription]; Region: GntR; COG1802 483179007399 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 483179007400 DNA-binding site [nucleotide binding]; DNA binding site 483179007401 FCD domain; Region: FCD; pfam07729 483179007402 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 483179007403 Domain of unknown function DUF20; Region: UPF0118; pfam01594 483179007404 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 483179007405 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 483179007406 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 483179007407 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 483179007408 Peptidase family M23; Region: Peptidase_M23; pfam01551 483179007409 HlyD family secretion protein; Region: HlyD_3; pfam13437 483179007410 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 483179007411 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 483179007412 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 483179007413 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 483179007414 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 483179007415 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179007416 dimer interface [polypeptide binding]; other site 483179007417 conserved gate region; other site 483179007418 putative PBP binding loops; other site 483179007419 ABC-ATPase subunit interface; other site 483179007420 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 483179007421 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 483179007422 Walker A/P-loop; other site 483179007423 ATP binding site [chemical binding]; other site 483179007424 Q-loop/lid; other site 483179007425 ABC transporter signature motif; other site 483179007426 Walker B; other site 483179007427 D-loop; other site 483179007428 H-loop/switch region; other site 483179007429 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 483179007430 NMT1/THI5 like; Region: NMT1; pfam09084 483179007431 substrate binding pocket [chemical binding]; other site 483179007432 membrane-bound complex binding site; other site 483179007433 hinge residues; other site 483179007434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483179007435 putative substrate translocation pore; other site 483179007436 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 483179007437 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 483179007438 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 483179007439 HlyD family secretion protein; Region: HlyD_3; pfam13437 483179007440 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483179007441 HAMP domain; Region: HAMP; pfam00672 483179007442 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483179007443 dimer interface [polypeptide binding]; other site 483179007444 phosphorylation site [posttranslational modification] 483179007445 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483179007446 ATP binding site [chemical binding]; other site 483179007447 Mg2+ binding site [ion binding]; other site 483179007448 G-X-G motif; other site 483179007449 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 483179007450 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483179007451 active site 483179007452 phosphorylation site [posttranslational modification] 483179007453 intermolecular recognition site; other site 483179007454 dimerization interface [polypeptide binding]; other site 483179007455 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 483179007456 DNA binding site [nucleotide binding] 483179007457 Uncharacterized conserved protein [Function unknown]; Region: COG3189 483179007458 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 483179007459 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 483179007460 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 483179007461 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 483179007462 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 483179007463 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 483179007464 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 483179007465 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 483179007466 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 483179007467 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 483179007468 Homoserine trans-succinylase [Amino acid transport and metabolism]; Region: MetA; COG1897 483179007469 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 483179007470 proposed active site lysine [active] 483179007471 conserved cys residue [active] 483179007472 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 483179007473 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 483179007474 active site 483179007475 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05963 483179007476 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 483179007477 dimer interface [polypeptide binding]; other site 483179007478 active site 483179007479 CoA binding pocket [chemical binding]; other site 483179007480 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 483179007481 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 483179007482 inhibitor-cofactor binding pocket; inhibition site 483179007483 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483179007484 catalytic residue [active] 483179007485 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 483179007486 AAA domain; Region: AAA_26; pfam13500 483179007487 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 483179007488 hypothetical protein; Provisional; Region: PRK07505 483179007489 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 483179007490 catalytic residue [active] 483179007491 biotin synthase; Region: bioB; TIGR00433 483179007492 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 483179007493 FeS/SAM binding site; other site 483179007494 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 483179007495 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 483179007496 MPT binding site; other site 483179007497 trimer interface [polypeptide binding]; other site 483179007498 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 483179007499 dimer interface [polypeptide binding]; other site 483179007500 FMN binding site [chemical binding]; other site 483179007501 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 483179007502 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 483179007503 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 483179007504 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 483179007505 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 483179007506 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 483179007507 monovalent cation:proton antiporter; Region: 2a6301s02; TIGR00943 483179007508 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 483179007509 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 483179007510 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 483179007511 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12596 483179007512 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 483179007513 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12671 483179007514 Predicted transcriptional regulators [Transcription]; Region: COG1510 483179007515 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 483179007516 dimerization interface [polypeptide binding]; other site 483179007517 putative DNA binding site [nucleotide binding]; other site 483179007518 putative Zn2+ binding site [ion binding]; other site 483179007519 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 483179007520 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 483179007521 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 483179007522 Walker A/P-loop; other site 483179007523 ATP binding site [chemical binding]; other site 483179007524 Q-loop/lid; other site 483179007525 ABC transporter signature motif; other site 483179007526 Walker B; other site 483179007527 D-loop; other site 483179007528 H-loop/switch region; other site 483179007529 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 483179007530 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483179007531 Walker A/P-loop; other site 483179007532 ATP binding site [chemical binding]; other site 483179007533 Q-loop/lid; other site 483179007534 ABC transporter signature motif; other site 483179007535 Walker B; other site 483179007536 D-loop; other site 483179007537 H-loop/switch region; other site 483179007538 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 483179007539 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 483179007540 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 483179007541 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 483179007542 Predicted outer membrane lipoprotein [Function unknown]; Region: COG4890 483179007543 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 483179007544 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 483179007545 DNA-binding site [nucleotide binding]; DNA binding site 483179007546 UTRA domain; Region: UTRA; pfam07702 483179007547 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 483179007548 nucleotide binding site [chemical binding]; other site 483179007549 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 483179007550 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 483179007551 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 483179007552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179007553 dimer interface [polypeptide binding]; other site 483179007554 conserved gate region; other site 483179007555 putative PBP binding loops; other site 483179007556 ABC-ATPase subunit interface; other site 483179007557 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 483179007558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179007559 dimer interface [polypeptide binding]; other site 483179007560 conserved gate region; other site 483179007561 putative PBP binding loops; other site 483179007562 ABC-ATPase subunit interface; other site 483179007563 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 483179007564 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 483179007565 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 483179007566 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 483179007567 Walker A/P-loop; other site 483179007568 ATP binding site [chemical binding]; other site 483179007569 Q-loop/lid; other site 483179007570 ABC transporter signature motif; other site 483179007571 Walker B; other site 483179007572 D-loop; other site 483179007573 H-loop/switch region; other site 483179007574 TOBE domain; Region: TOBE_2; pfam08402 483179007575 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573 483179007576 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 483179007577 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 483179007578 tetramer interface [polypeptide binding]; other site 483179007579 TPP-binding site [chemical binding]; other site 483179007580 heterodimer interface [polypeptide binding]; other site 483179007581 phosphorylation loop region [posttranslational modification] 483179007582 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 483179007583 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 483179007584 alpha subunit interface [polypeptide binding]; other site 483179007585 TPP binding site [chemical binding]; other site 483179007586 heterodimer interface [polypeptide binding]; other site 483179007587 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 483179007588 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 483179007589 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 483179007590 E3 interaction surface; other site 483179007591 lipoyl attachment site [posttranslational modification]; other site 483179007592 e3 binding domain; Region: E3_binding; pfam02817 483179007593 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 483179007594 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 483179007595 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 483179007596 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 483179007597 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 483179007598 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 483179007599 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 483179007600 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 483179007601 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 483179007602 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 483179007603 homodimer interface [polypeptide binding]; other site 483179007604 homotetramer interface [polypeptide binding]; other site 483179007605 active site pocket [active] 483179007606 cleavage site 483179007607 benzoate transport; Region: 2A0115; TIGR00895 483179007608 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483179007609 putative substrate translocation pore; other site 483179007610 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 483179007611 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 483179007612 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 483179007613 Walker A/P-loop; other site 483179007614 ATP binding site [chemical binding]; other site 483179007615 Q-loop/lid; other site 483179007616 ABC transporter signature motif; other site 483179007617 Walker B; other site 483179007618 D-loop; other site 483179007619 H-loop/switch region; other site 483179007620 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 483179007621 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 483179007622 Walker A/P-loop; other site 483179007623 ATP binding site [chemical binding]; other site 483179007624 Q-loop/lid; other site 483179007625 ABC transporter signature motif; other site 483179007626 Walker B; other site 483179007627 D-loop; other site 483179007628 H-loop/switch region; other site 483179007629 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 483179007630 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 483179007631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179007632 dimer interface [polypeptide binding]; other site 483179007633 conserved gate region; other site 483179007634 ABC-ATPase subunit interface; other site 483179007635 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 483179007636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179007637 dimer interface [polypeptide binding]; other site 483179007638 conserved gate region; other site 483179007639 putative PBP binding loops; other site 483179007640 ABC-ATPase subunit interface; other site 483179007641 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 483179007642 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 483179007643 peptide binding site [polypeptide binding]; other site 483179007644 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 483179007645 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 483179007646 peptide binding site [polypeptide binding]; other site 483179007647 Predicted integral membrane protein [Function unknown]; Region: COG5455 483179007648 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 483179007649 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 483179007650 NAD binding site [chemical binding]; other site 483179007651 putative substrate binding site 2 [chemical binding]; other site 483179007652 putative substrate binding site 1 [chemical binding]; other site 483179007653 active site 483179007654 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 483179007655 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 483179007656 NAD binding site [chemical binding]; other site 483179007657 homodimer interface [polypeptide binding]; other site 483179007658 active site 483179007659 substrate binding site [chemical binding]; other site 483179007660 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 483179007661 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 483179007662 active site 483179007663 Cellulose synthase-like protein; Region: PLN02893 483179007664 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 483179007665 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 483179007666 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 483179007667 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 483179007668 Protein of unknown function (DUF995); Region: DUF995; pfam06191 483179007669 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 483179007670 Protein of unknown function (DUF995); Region: DUF995; pfam06191 483179007671 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 483179007672 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 483179007673 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 483179007674 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 483179007675 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 483179007676 yecA family protein; Region: ygfB_yecA; TIGR02292 483179007677 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 483179007678 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 483179007679 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 483179007680 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 483179007681 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 483179007682 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 483179007683 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 483179007684 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 483179007685 Transposase; Region: HTH_Tnp_1; pfam01527 483179007686 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 483179007687 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 483179007688 putative deacylase active site [active] 483179007689 iron-responsive transcriptional regulator; Reviewed; Region: rirA; PRK11920 483179007690 Predicted transcriptional regulator [Transcription]; Region: COG1959 483179007691 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 483179007692 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 483179007693 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 483179007694 heme binding site [chemical binding]; other site 483179007695 ferroxidase pore; other site 483179007696 ferroxidase diiron center [ion binding]; other site 483179007697 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 483179007698 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 483179007699 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 483179007700 FeS/SAM binding site; other site 483179007701 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 483179007702 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 483179007703 putative ligand binding site [chemical binding]; other site 483179007704 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 483179007705 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 483179007706 TM-ABC transporter signature motif; other site 483179007707 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 483179007708 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 483179007709 TM-ABC transporter signature motif; other site 483179007710 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 483179007711 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 483179007712 Walker A/P-loop; other site 483179007713 ATP binding site [chemical binding]; other site 483179007714 Q-loop/lid; other site 483179007715 ABC transporter signature motif; other site 483179007716 Walker B; other site 483179007717 D-loop; other site 483179007718 H-loop/switch region; other site 483179007719 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 483179007720 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 483179007721 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 483179007722 NADP binding site [chemical binding]; other site 483179007723 dimer interface [polypeptide binding]; other site 483179007724 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 483179007725 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 483179007726 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494 483179007727 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 483179007728 Uncharacterized conserved protein [Function unknown]; Region: COG3785 483179007729 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 483179007730 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 483179007731 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 483179007732 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 483179007733 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 483179007734 catalytic residues [active] 483179007735 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 483179007736 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 483179007737 active site 483179007738 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 483179007739 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 483179007740 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 483179007741 ATP binding site [chemical binding]; other site 483179007742 putative Mg++ binding site [ion binding]; other site 483179007743 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 483179007744 nucleotide binding region [chemical binding]; other site 483179007745 ATP-binding site [chemical binding]; other site 483179007746 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 483179007747 Uncharacterized conserved protein [Function unknown]; Region: COG2938 483179007748 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 483179007749 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 483179007750 generic binding surface II; other site 483179007751 ssDNA binding site; other site 483179007752 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 483179007753 ATP binding site [chemical binding]; other site 483179007754 putative Mg++ binding site [ion binding]; other site 483179007755 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 483179007756 nucleotide binding region [chemical binding]; other site 483179007757 ATP-binding site [chemical binding]; other site 483179007758 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 483179007759 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 483179007760 glutaminase active site [active] 483179007761 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 483179007762 dimer interface [polypeptide binding]; other site 483179007763 active site 483179007764 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 483179007765 dimer interface [polypeptide binding]; other site 483179007766 active site 483179007767 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 483179007768 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 483179007769 Substrate binding site; other site 483179007770 Mg++ binding site; other site 483179007771 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 483179007772 active site 483179007773 substrate binding site [chemical binding]; other site 483179007774 CoA binding site [chemical binding]; other site 483179007775 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 483179007776 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 483179007777 Predicted integral membrane protein [Function unknown]; Region: COG0392 483179007778 Uncharacterized conserved protein [Function unknown]; Region: COG2898 483179007779 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 483179007780 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 483179007781 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 483179007782 BA14K-like protein; Region: BA14K; pfam07886 483179007783 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483179007784 PAS domain; Region: PAS_9; pfam13426 483179007785 putative active site [active] 483179007786 heme pocket [chemical binding]; other site 483179007787 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483179007788 PAS fold; Region: PAS_3; pfam08447 483179007789 putative active site [active] 483179007790 heme pocket [chemical binding]; other site 483179007791 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 483179007792 HWE histidine kinase; Region: HWE_HK; pfam07536 483179007793 lipoate-protein ligase B; Provisional; Region: PRK14341 483179007794 EamA-like transporter family; Region: EamA; pfam00892 483179007795 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 483179007796 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 483179007797 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483179007798 Mg2+ binding site [ion binding]; other site 483179007799 G-X-G motif; other site 483179007800 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 483179007801 anchoring element; other site 483179007802 dimer interface [polypeptide binding]; other site 483179007803 ATP binding site [chemical binding]; other site 483179007804 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 483179007805 active site 483179007806 metal binding site [ion binding]; metal-binding site 483179007807 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 483179007808 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 483179007809 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 483179007810 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 483179007811 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 483179007812 metal-dependent hydrolase; Provisional; Region: PRK00685 483179007813 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 483179007814 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 483179007815 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 483179007816 active site 483179007817 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 483179007818 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 483179007819 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 483179007820 dihydroorotase; Validated; Region: PRK09059 483179007821 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 483179007822 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 483179007823 active site 483179007824 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 483179007825 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 483179007826 DNA protecting protein DprA; Region: dprA; TIGR00732 483179007827 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 483179007828 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 483179007829 active site 483179007830 interdomain interaction site; other site 483179007831 putative metal-binding site [ion binding]; other site 483179007832 nucleotide binding site [chemical binding]; other site 483179007833 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 483179007834 domain I; other site 483179007835 DNA binding groove [nucleotide binding] 483179007836 phosphate binding site [ion binding]; other site 483179007837 domain II; other site 483179007838 domain III; other site 483179007839 nucleotide binding site [chemical binding]; other site 483179007840 catalytic site [active] 483179007841 domain IV; other site 483179007842 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 483179007843 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 483179007844 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 483179007845 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 483179007846 ribonuclease R; Region: RNase_R; TIGR02063 483179007847 RNB domain; Region: RNB; pfam00773 483179007848 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 483179007849 RNA binding site [nucleotide binding]; other site 483179007850 hypothetical protein; Provisional; Region: PRK05978 483179007851 Major Facilitator Superfamily; Region: MFS_1; pfam07690 483179007852 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483179007853 putative substrate translocation pore; other site 483179007854 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 483179007855 response regulator PleD; Reviewed; Region: pleD; PRK09581 483179007856 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483179007857 active site 483179007858 phosphorylation site [posttranslational modification] 483179007859 intermolecular recognition site; other site 483179007860 dimerization interface [polypeptide binding]; other site 483179007861 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483179007862 active site 483179007863 phosphorylation site [posttranslational modification] 483179007864 intermolecular recognition site; other site 483179007865 dimerization interface [polypeptide binding]; other site 483179007866 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 483179007867 metal binding site [ion binding]; metal-binding site 483179007868 active site 483179007869 I-site; other site 483179007870 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 483179007871 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483179007872 active site 483179007873 phosphorylation site [posttranslational modification] 483179007874 intermolecular recognition site; other site 483179007875 dimerization interface [polypeptide binding]; other site 483179007876 Protein of unknown function (DUF3572); Region: DUF3572; pfam12096 483179007877 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 483179007878 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 483179007879 DNA polymerase IV; Provisional; Region: PRK02794 483179007880 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 483179007881 active site 483179007882 DNA binding site [nucleotide binding] 483179007883 Uncharacterized conserved protein [Function unknown]; Region: COG3391 483179007884 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 483179007885 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 483179007886 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 483179007887 metal binding site [ion binding]; metal-binding site 483179007888 active site 483179007889 I-site; other site 483179007890 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 483179007891 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 483179007892 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 483179007893 active site 483179007894 catalytic site [active] 483179007895 substrate binding site [chemical binding]; other site 483179007896 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 483179007897 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 483179007898 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 483179007899 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 483179007900 hydroxyglutarate oxidase; Provisional; Region: PRK11728 483179007901 hydroxyglutarate oxidase; Provisional; Region: PRK11728 483179007902 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 483179007903 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 483179007904 substrate binding pocket [chemical binding]; other site 483179007905 membrane-bound complex binding site; other site 483179007906 hinge residues; other site 483179007907 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 483179007908 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 483179007909 substrate binding pocket [chemical binding]; other site 483179007910 membrane-bound complex binding site; other site 483179007911 hinge residues; other site 483179007912 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 483179007913 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483179007914 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 483179007915 putative DNA binding site [nucleotide binding]; other site 483179007916 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 483179007917 putative Zn2+ binding site [ion binding]; other site 483179007918 AsnC family; Region: AsnC_trans_reg; pfam01037 483179007919 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 483179007920 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 483179007921 active site 483179007922 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 483179007923 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 483179007924 dimer interface [polypeptide binding]; other site 483179007925 active site 483179007926 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 483179007927 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 483179007928 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 483179007929 Bacterial transcriptional regulator; Region: IclR; pfam01614 483179007930 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 483179007931 Cupin domain; Region: Cupin_2; cl17218 483179007932 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 483179007933 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 483179007934 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 483179007935 hypothetical protein; Provisional; Region: PRK07236 483179007936 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 483179007937 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 483179007938 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 483179007939 dimerization interface [polypeptide binding]; other site 483179007940 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 483179007941 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 483179007942 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 483179007943 Protocatechuate 3,4-dioxygenase beta subunit N terminal; Region: PCDO_beta_N; pfam12391 483179007944 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 483179007945 active site 483179007946 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK05975 483179007947 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 483179007948 tetramer interface [polypeptide binding]; other site 483179007949 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 483179007950 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 483179007951 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 483179007952 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 483179007953 TM-ABC transporter signature motif; other site 483179007954 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 483179007955 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 483179007956 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 483179007957 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 483179007958 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 483179007959 Walker A/P-loop; other site 483179007960 ATP binding site [chemical binding]; other site 483179007961 Q-loop/lid; other site 483179007962 ABC transporter signature motif; other site 483179007963 Walker B; other site 483179007964 D-loop; other site 483179007965 H-loop/switch region; other site 483179007966 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 483179007967 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 483179007968 Walker A/P-loop; other site 483179007969 ATP binding site [chemical binding]; other site 483179007970 Q-loop/lid; other site 483179007971 ABC transporter signature motif; other site 483179007972 Walker B; other site 483179007973 D-loop; other site 483179007974 H-loop/switch region; other site 483179007975 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 483179007976 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 483179007977 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 483179007978 active site 483179007979 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 483179007980 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 483179007981 active site 483179007982 dimer interface [polypeptide binding]; other site 483179007983 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 483179007984 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 483179007985 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 483179007986 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179007987 dimer interface [polypeptide binding]; other site 483179007988 conserved gate region; other site 483179007989 ABC-ATPase subunit interface; other site 483179007990 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 483179007991 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 483179007992 Walker A/P-loop; other site 483179007993 ATP binding site [chemical binding]; other site 483179007994 Q-loop/lid; other site 483179007995 ABC transporter signature motif; other site 483179007996 Walker B; other site 483179007997 D-loop; other site 483179007998 H-loop/switch region; other site 483179007999 TOBE domain; Region: TOBE_2; pfam08402 483179008000 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 483179008001 transmembrane helices; other site 483179008002 TrkA-C domain; Region: TrkA_C; pfam02080 483179008003 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 483179008004 TrkA-C domain; Region: TrkA_C; pfam02080 483179008005 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 483179008006 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 483179008007 nucleoside/Zn binding site; other site 483179008008 dimer interface [polypeptide binding]; other site 483179008009 catalytic motif [active] 483179008010 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 483179008011 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 483179008012 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 483179008013 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 483179008014 EamA-like transporter family; Region: EamA; pfam00892 483179008015 aminotransferase; Provisional; Region: PRK13356 483179008016 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 483179008017 homodimer interface [polypeptide binding]; other site 483179008018 substrate-cofactor binding pocket; other site 483179008019 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483179008020 catalytic residue [active] 483179008021 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 483179008022 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 483179008023 FAD binding domain; Region: FAD_binding_2; pfam00890 483179008024 Protein of unknown function (DUF3775); Region: DUF3775; pfam12616 483179008025 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 483179008026 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 483179008027 NAD binding site [chemical binding]; other site 483179008028 catalytic residues [active] 483179008029 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 483179008030 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 483179008031 putative ligand binding residues [chemical binding]; other site 483179008032 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 483179008033 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 483179008034 ABC-ATPase subunit interface; other site 483179008035 dimer interface [polypeptide binding]; other site 483179008036 putative PBP binding regions; other site 483179008037 ABC-type enterochelin transport system, permease component [Inorganic ion transport and metabolism]; Region: CeuC; COG4605 483179008038 ABC-ATPase subunit interface; other site 483179008039 dimer interface [polypeptide binding]; other site 483179008040 putative PBP binding regions; other site 483179008041 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 483179008042 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 483179008043 Walker A/P-loop; other site 483179008044 ATP binding site [chemical binding]; other site 483179008045 Q-loop/lid; other site 483179008046 ABC transporter signature motif; other site 483179008047 Walker B; other site 483179008048 D-loop; other site 483179008049 H-loop/switch region; other site 483179008050 Predicted transcription regulator, contains HTH domain (MarR family) [Transcription]; Region: COG5631 483179008051 5-oxoprolinase; Region: PLN02666 483179008052 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 483179008053 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 483179008054 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 483179008055 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 483179008056 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 483179008057 substrate binding pocket [chemical binding]; other site 483179008058 membrane-bound complex binding site; other site 483179008059 hinge residues; other site 483179008060 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179008061 dimer interface [polypeptide binding]; other site 483179008062 conserved gate region; other site 483179008063 putative PBP binding loops; other site 483179008064 ABC-ATPase subunit interface; other site 483179008065 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 483179008066 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483179008067 Walker A/P-loop; other site 483179008068 ATP binding site [chemical binding]; other site 483179008069 Q-loop/lid; other site 483179008070 ABC transporter signature motif; other site 483179008071 Walker B; other site 483179008072 D-loop; other site 483179008073 H-loop/switch region; other site 483179008074 exopolyphosphatase; Region: exo_poly_only; TIGR03706 483179008075 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 483179008076 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 483179008077 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483179008078 S-adenosylmethionine binding site [chemical binding]; other site 483179008079 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483179008080 putative transporter; Provisional; Region: PRK10504 483179008081 putative substrate translocation pore; other site 483179008082 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483179008083 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 483179008084 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 483179008085 Walker A/P-loop; other site 483179008086 ATP binding site [chemical binding]; other site 483179008087 Q-loop/lid; other site 483179008088 ABC transporter signature motif; other site 483179008089 Walker B; other site 483179008090 D-loop; other site 483179008091 H-loop/switch region; other site 483179008092 TOBE domain; Region: TOBE_2; pfam08402 483179008093 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 483179008094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179008095 dimer interface [polypeptide binding]; other site 483179008096 conserved gate region; other site 483179008097 putative PBP binding loops; other site 483179008098 ABC-ATPase subunit interface; other site 483179008099 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179008100 dimer interface [polypeptide binding]; other site 483179008101 conserved gate region; other site 483179008102 putative PBP binding loops; other site 483179008103 ABC-ATPase subunit interface; other site 483179008104 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 483179008105 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 483179008106 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-II; Region: Lumazine_synthase-II; cd09208 483179008107 active site 483179008108 homopentamer interface [polypeptide binding]; other site 483179008109 dimer interface [polypeptide binding]; other site 483179008110 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 483179008111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3453 483179008112 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 483179008113 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179008114 dimer interface [polypeptide binding]; other site 483179008115 conserved gate region; other site 483179008116 putative PBP binding loops; other site 483179008117 ABC-ATPase subunit interface; other site 483179008118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179008119 dimer interface [polypeptide binding]; other site 483179008120 conserved gate region; other site 483179008121 putative PBP binding loops; other site 483179008122 ABC-ATPase subunit interface; other site 483179008123 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 483179008124 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 483179008125 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 483179008126 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 483179008127 Walker A/P-loop; other site 483179008128 ATP binding site [chemical binding]; other site 483179008129 Q-loop/lid; other site 483179008130 ABC transporter signature motif; other site 483179008131 Walker B; other site 483179008132 D-loop; other site 483179008133 H-loop/switch region; other site 483179008134 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 483179008135 hydroxyglutarate oxidase; Provisional; Region: PRK11728 483179008136 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 483179008137 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 483179008138 E-class dimer interface [polypeptide binding]; other site 483179008139 P-class dimer interface [polypeptide binding]; other site 483179008140 active site 483179008141 Cu2+ binding site [ion binding]; other site 483179008142 Zn2+ binding site [ion binding]; other site 483179008143 multicopper oxidase; Provisional; Region: PRK10965 483179008144 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 483179008145 Multicopper oxidase; Region: Cu-oxidase; pfam00394 483179008146 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 483179008147 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483179008148 metabolite-proton symporter; Region: 2A0106; TIGR00883 483179008149 putative substrate translocation pore; other site 483179008150 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 483179008151 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 483179008152 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 483179008153 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 483179008154 dimer interface [polypeptide binding]; other site 483179008155 decamer (pentamer of dimers) interface [polypeptide binding]; other site 483179008156 catalytic triad [active] 483179008157 peroxidatic and resolving cysteines [active] 483179008158 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 483179008159 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 483179008160 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 483179008161 dimerization interface [polypeptide binding]; other site 483179008162 Protein of unknown function (DUF1612); Region: DUF1612; pfam07756 483179008163 HTH DNA binding domain; Region: HTH_13; pfam11972 483179008164 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 483179008165 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 483179008166 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 483179008167 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 483179008168 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 483179008169 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 483179008170 putative active site [active] 483179008171 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 483179008172 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 483179008173 PYR/PP interface [polypeptide binding]; other site 483179008174 dimer interface [polypeptide binding]; other site 483179008175 TPP binding site [chemical binding]; other site 483179008176 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 483179008177 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 483179008178 TPP-binding site [chemical binding]; other site 483179008179 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 483179008180 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 483179008181 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 483179008182 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 483179008183 active site 483179008184 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 483179008185 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483179008186 Walker A/P-loop; other site 483179008187 ATP binding site [chemical binding]; other site 483179008188 Q-loop/lid; other site 483179008189 ABC transporter signature motif; other site 483179008190 Walker B; other site 483179008191 D-loop; other site 483179008192 H-loop/switch region; other site 483179008193 TOBE domain; Region: TOBE_2; pfam08402 483179008194 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 483179008195 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179008196 dimer interface [polypeptide binding]; other site 483179008197 conserved gate region; other site 483179008198 putative PBP binding loops; other site 483179008199 ABC-ATPase subunit interface; other site 483179008200 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179008201 dimer interface [polypeptide binding]; other site 483179008202 conserved gate region; other site 483179008203 putative PBP binding loops; other site 483179008204 ABC-ATPase subunit interface; other site 483179008205 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 483179008206 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 483179008207 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 483179008208 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 483179008209 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 483179008210 Glutamate binding site [chemical binding]; other site 483179008211 NAD binding site [chemical binding]; other site 483179008212 catalytic residues [active] 483179008213 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 483179008214 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 483179008215 putative DNA binding site [nucleotide binding]; other site 483179008216 putative Zn2+ binding site [ion binding]; other site 483179008217 AsnC family; Region: AsnC_trans_reg; pfam01037 483179008218 glycine dehydrogenase; Provisional; Region: PRK05367 483179008219 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 483179008220 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 483179008221 catalytic residue [active] 483179008222 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 483179008223 tetramer interface [polypeptide binding]; other site 483179008224 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483179008225 catalytic residue [active] 483179008226 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 483179008227 lipoyl attachment site [posttranslational modification]; other site 483179008228 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 483179008229 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 483179008230 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 483179008231 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 483179008232 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 483179008233 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 483179008234 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 483179008235 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 483179008236 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 483179008237 putative active site [active] 483179008238 Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931 483179008239 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 483179008240 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 483179008241 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 483179008242 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 483179008243 putative active site [active] 483179008244 metal binding site [ion binding]; metal-binding site 483179008245 BA14K-like protein; Region: BA14K; pfam07886 483179008246 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 483179008247 EamA-like transporter family; Region: EamA; pfam00892 483179008248 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 483179008249 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 483179008250 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179008251 dimer interface [polypeptide binding]; other site 483179008252 conserved gate region; other site 483179008253 putative PBP binding loops; other site 483179008254 ABC-ATPase subunit interface; other site 483179008255 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 483179008256 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 483179008257 Walker A/P-loop; other site 483179008258 ATP binding site [chemical binding]; other site 483179008259 Q-loop/lid; other site 483179008260 ABC transporter signature motif; other site 483179008261 Walker B; other site 483179008262 D-loop; other site 483179008263 H-loop/switch region; other site 483179008264 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 483179008265 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 483179008266 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 483179008267 dimer interface [polypeptide binding]; other site 483179008268 active site 483179008269 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 483179008270 substrate binding site [chemical binding]; other site 483179008271 catalytic residue [active] 483179008272 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 483179008273 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 483179008274 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 483179008275 putative active site [active] 483179008276 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 483179008277 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 483179008278 Walker A/P-loop; other site 483179008279 ATP binding site [chemical binding]; other site 483179008280 Q-loop/lid; other site 483179008281 ABC transporter signature motif; other site 483179008282 Walker B; other site 483179008283 D-loop; other site 483179008284 H-loop/switch region; other site 483179008285 TOBE domain; Region: TOBE_2; pfam08402 483179008286 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 483179008287 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483179008288 NAD(P) binding site [chemical binding]; other site 483179008289 active site 483179008290 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 483179008291 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 483179008292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179008293 dimer interface [polypeptide binding]; other site 483179008294 conserved gate region; other site 483179008295 putative PBP binding loops; other site 483179008296 ABC-ATPase subunit interface; other site 483179008297 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 483179008298 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179008299 dimer interface [polypeptide binding]; other site 483179008300 conserved gate region; other site 483179008301 putative PBP binding loops; other site 483179008302 ABC-ATPase subunit interface; other site 483179008303 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 483179008304 homotrimer interaction site [polypeptide binding]; other site 483179008305 putative active site [active] 483179008306 Uncharacterized conserved protein [Function unknown]; Region: COG5476 483179008307 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 483179008308 MlrC C-terminus; Region: MlrC_C; pfam07171 483179008309 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 483179008310 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 483179008311 Walker A/P-loop; other site 483179008312 ATP binding site [chemical binding]; other site 483179008313 Q-loop/lid; other site 483179008314 ABC transporter signature motif; other site 483179008315 Walker B; other site 483179008316 D-loop; other site 483179008317 H-loop/switch region; other site 483179008318 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 483179008319 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 483179008320 ABC-ATPase subunit interface; other site 483179008321 dimer interface [polypeptide binding]; other site 483179008322 putative PBP binding regions; other site 483179008323 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 483179008324 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 483179008325 putative ligand binding residues [chemical binding]; other site 483179008326 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 483179008327 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 483179008328 HlyD family secretion protein; Region: HlyD_3; pfam13437 483179008329 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 483179008330 Fusaric acid resistance protein family; Region: FUSC; pfam04632 483179008331 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 483179008332 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 483179008333 MarR family; Region: MarR_2; pfam12802 483179008334 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 483179008335 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 483179008336 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 483179008337 generic binding surface II; other site 483179008338 generic binding surface I; other site 483179008339 Transcriptional regulator [Transcription]; Region: LysR; COG0583 483179008340 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 483179008341 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 483179008342 dimerization interface [polypeptide binding]; other site 483179008343 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 483179008344 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 483179008345 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 483179008346 hypothetical protein; Reviewed; Region: PRK12275 483179008347 four helix bundle protein; Region: TIGR02436 483179008348 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 483179008349 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 483179008350 Transcriptional regulators [Transcription]; Region: MarR; COG1846 483179008351 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 483179008352 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 483179008353 putative DNA binding site [nucleotide binding]; other site 483179008354 putative Zn2+ binding site [ion binding]; other site 483179008355 AsnC family; Region: AsnC_trans_reg; pfam01037 483179008356 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 483179008357 Predicted membrane protein [Function unknown]; Region: COG4541 483179008358 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345 483179008359 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 483179008360 putative NAD(P) binding site [chemical binding]; other site 483179008361 active site 483179008362 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 483179008363 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 483179008364 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 483179008365 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 483179008366 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 483179008367 putative active site [active] 483179008368 phosphogluconate dehydratase; Validated; Region: PRK09054 483179008369 6-phosphogluconate dehydratase; Region: edd; TIGR01196 483179008370 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 483179008371 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 483179008372 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 483179008373 homodimer interface [polypeptide binding]; other site 483179008374 NADP binding site [chemical binding]; other site 483179008375 substrate binding site [chemical binding]; other site 483179008376 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 483179008377 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 483179008378 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 483179008379 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 483179008380 Walker A/P-loop; other site 483179008381 ATP binding site [chemical binding]; other site 483179008382 Q-loop/lid; other site 483179008383 ABC transporter signature motif; other site 483179008384 Walker B; other site 483179008385 D-loop; other site 483179008386 H-loop/switch region; other site 483179008387 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 483179008388 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 483179008389 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 483179008390 Walker A/P-loop; other site 483179008391 ATP binding site [chemical binding]; other site 483179008392 Q-loop/lid; other site 483179008393 ABC transporter signature motif; other site 483179008394 Walker B; other site 483179008395 D-loop; other site 483179008396 H-loop/switch region; other site 483179008397 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 483179008398 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179008399 dimer interface [polypeptide binding]; other site 483179008400 conserved gate region; other site 483179008401 putative PBP binding loops; other site 483179008402 ABC-ATPase subunit interface; other site 483179008403 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 483179008404 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179008405 dimer interface [polypeptide binding]; other site 483179008406 conserved gate region; other site 483179008407 putative PBP binding loops; other site 483179008408 ABC-ATPase subunit interface; other site 483179008409 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 483179008410 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 483179008411 Eukaryotic translation initiation factor 3 subunit 8 N-terminus; Region: eIF-3c_N; pfam05470 483179008412 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 483179008413 active site clefts [active] 483179008414 zinc binding site [ion binding]; other site 483179008415 dimer interface [polypeptide binding]; other site 483179008416 tellurite resistance protein terB; Region: terB; cd07176 483179008417 putative metal binding site [ion binding]; other site 483179008418 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 483179008419 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 483179008420 active site 483179008421 nucleotide binding site [chemical binding]; other site 483179008422 HIGH motif; other site 483179008423 KMSKS motif; other site 483179008424 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 483179008425 Predicted transcriptional regulator [Transcription]; Region: COG2932 483179008426 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 483179008427 Catalytic site [active] 483179008428 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 483179008429 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 483179008430 substrate binding site [chemical binding]; other site 483179008431 oxyanion hole (OAH) forming residues; other site 483179008432 trimer interface [polypeptide binding]; other site 483179008433 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 483179008434 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 483179008435 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 483179008436 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 483179008437 dimer interface [polypeptide binding]; other site 483179008438 active site 483179008439 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 483179008440 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 483179008441 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 483179008442 FAD binding site [chemical binding]; other site 483179008443 substrate binding site [chemical binding]; other site 483179008444 catalytic residues [active] 483179008445 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 483179008446 Transcriptional regulator [Transcription]; Region: LysR; COG0583 483179008447 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 483179008448 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 483179008449 putative dimerization interface [polypeptide binding]; other site 483179008450 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 483179008451 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 483179008452 active site 483179008453 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 483179008454 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 483179008455 Walker A/P-loop; other site 483179008456 ATP binding site [chemical binding]; other site 483179008457 Q-loop/lid; other site 483179008458 ABC transporter signature motif; other site 483179008459 Walker B; other site 483179008460 D-loop; other site 483179008461 H-loop/switch region; other site 483179008462 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 483179008463 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 483179008464 Walker A/P-loop; other site 483179008465 ATP binding site [chemical binding]; other site 483179008466 Q-loop/lid; other site 483179008467 ABC transporter signature motif; other site 483179008468 Walker B; other site 483179008469 D-loop; other site 483179008470 H-loop/switch region; other site 483179008471 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 483179008472 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179008473 dimer interface [polypeptide binding]; other site 483179008474 conserved gate region; other site 483179008475 putative PBP binding loops; other site 483179008476 ABC-ATPase subunit interface; other site 483179008477 nickel transporter permease NikB; Provisional; Region: PRK10352 483179008478 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179008479 dimer interface [polypeptide binding]; other site 483179008480 conserved gate region; other site 483179008481 putative PBP binding loops; other site 483179008482 ABC-ATPase subunit interface; other site 483179008483 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 483179008484 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 483179008485 substrate binding site [chemical binding]; other site 483179008486 nickel responsive regulator; Provisional; Region: PRK02967 483179008487 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 483179008488 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 483179008489 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 483179008490 galactarate dehydratase; Region: galactar-dH20; TIGR03248 483179008491 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 483179008492 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 483179008493 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179008494 dimer interface [polypeptide binding]; other site 483179008495 conserved gate region; other site 483179008496 putative PBP binding loops; other site 483179008497 ABC-ATPase subunit interface; other site 483179008498 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179008499 putative PBP binding loops; other site 483179008500 ABC-ATPase subunit interface; other site 483179008501 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 483179008502 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483179008503 Walker A/P-loop; other site 483179008504 ATP binding site [chemical binding]; other site 483179008505 Q-loop/lid; other site 483179008506 ABC transporter signature motif; other site 483179008507 Walker B; other site 483179008508 D-loop; other site 483179008509 H-loop/switch region; other site 483179008510 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 483179008511 hypothetical protein; Provisional; Region: PRK11622 483179008512 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 483179008513 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 483179008514 glucuronate isomerase; Reviewed; Region: PRK02925 483179008515 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 483179008516 Transcriptional regulators [Transcription]; Region: GntR; COG1802 483179008517 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 483179008518 DNA-binding site [nucleotide binding]; DNA binding site 483179008519 FCD domain; Region: FCD; pfam07729 483179008520 mannonate dehydratase; Region: uxuA; TIGR00695 483179008521 mannonate dehydratase; Provisional; Region: PRK03906 483179008522 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 483179008523 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 483179008524 HlyD family secretion protein; Region: HlyD_3; pfam13437 483179008525 camphor resistance protein CrcB; Provisional; Region: PRK14233 483179008526 camphor resistance protein CrcB; Provisional; Region: PRK14225 483179008527 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 483179008528 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 483179008529 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 483179008530 DNA binding residues [nucleotide binding] 483179008531 putative dimer interface [polypeptide binding]; other site 483179008532 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 483179008533 Sel1-like repeats; Region: SEL1; smart00671 483179008534 Sel1-like repeats; Region: SEL1; smart00671 483179008535 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 483179008536 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 483179008537 conserved hypothetical protein; Region: alph_Pro_TM; TIGR02186 483179008538 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 483179008539 putative active site [active] 483179008540 putative metal binding site [ion binding]; other site 483179008541 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 483179008542 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 483179008543 ATP binding site [chemical binding]; other site 483179008544 putative Mg++ binding site [ion binding]; other site 483179008545 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 483179008546 nucleotide binding region [chemical binding]; other site 483179008547 ATP-binding site [chemical binding]; other site 483179008548 DEAD/H associated; Region: DEAD_assoc; pfam08494 483179008549 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 483179008550 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 483179008551 FMN binding site [chemical binding]; other site 483179008552 substrate binding site [chemical binding]; other site 483179008553 putative catalytic residue [active] 483179008554 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 483179008555 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 483179008556 HsdM N-terminal domain; Region: HsdM_N; pfam12161 483179008557 Methyltransferase domain; Region: Methyltransf_26; pfam13659 483179008558 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 483179008559 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 483179008560 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 483179008561 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 483179008562 ATP binding site [chemical binding]; other site 483179008563 putative Mg++ binding site [ion binding]; other site 483179008564 helicase superfamily c-terminal domain; Region: HELICc; smart00490 483179008565 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 483179008566 Protein of unknown function DUF45; Region: DUF45; pfam01863 483179008567 Protein of unknown function DUF91; Region: DUF91; cl00709 483179008568 Uncharacterized conserved protein [Function unknown]; Region: COG3586 483179008569 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 483179008570 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 483179008571 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 483179008572 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 483179008573 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 483179008574 inhibitor-cofactor binding pocket; inhibition site 483179008575 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483179008576 catalytic residue [active] 483179008577 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 483179008578 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483179008579 NAD(P) binding site [chemical binding]; other site 483179008580 active site 483179008581 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 483179008582 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 483179008583 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 483179008584 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 483179008585 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 483179008586 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 483179008587 ligand binding site [chemical binding]; other site 483179008588 dimerization interface [polypeptide binding]; other site 483179008589 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 483179008590 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 483179008591 TM-ABC transporter signature motif; other site 483179008592 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 483179008593 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 483179008594 Walker A/P-loop; other site 483179008595 ATP binding site [chemical binding]; other site 483179008596 Q-loop/lid; other site 483179008597 ABC transporter signature motif; other site 483179008598 Walker B; other site 483179008599 D-loop; other site 483179008600 H-loop/switch region; other site 483179008601 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 483179008602 Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; pfam10054 483179008603 glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369 483179008604 hydroxyglutarate oxidase; Provisional; Region: PRK11728 483179008605 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 483179008606 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 483179008607 PCI domain; Region: PCI; cl02111 483179008608 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 483179008609 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 483179008610 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 483179008611 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 483179008612 triosephosphate isomerase; Provisional; Region: PRK14565 483179008613 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 483179008614 substrate binding site [chemical binding]; other site 483179008615 dimer interface [polypeptide binding]; other site 483179008616 catalytic triad [active] 483179008617 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 483179008618 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 483179008619 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 483179008620 intersubunit interface [polypeptide binding]; other site 483179008621 active site 483179008622 zinc binding site [ion binding]; other site 483179008623 Na+ binding site [ion binding]; other site 483179008624 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 483179008625 AMP binding site [chemical binding]; other site 483179008626 metal binding site [ion binding]; metal-binding site 483179008627 active site 483179008628 Uncharacterized conserved protein [Function unknown]; Region: COG1739 483179008629 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 483179008630 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 483179008631 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 483179008632 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 483179008633 G1 box; other site 483179008634 putative GEF interaction site [polypeptide binding]; other site 483179008635 GTP/Mg2+ binding site [chemical binding]; other site 483179008636 Switch I region; other site 483179008637 G2 box; other site 483179008638 G3 box; other site 483179008639 Switch II region; other site 483179008640 G4 box; other site 483179008641 G5 box; other site 483179008642 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 483179008643 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 483179008644 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 483179008645 MgtE intracellular N domain; Region: MgtE_N; pfam03448 483179008646 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 483179008647 Divalent cation transporter; Region: MgtE; pfam01769 483179008648 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 483179008649 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 483179008650 active site 483179008651 Zn binding site [ion binding]; other site 483179008652 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 483179008653 dimer interface [polypeptide binding]; other site 483179008654 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 483179008655 Uncharacterized conserved small protein [Function unknown]; Region: COG5515 483179008656 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 483179008657 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 483179008658 substrate binding site [chemical binding]; other site 483179008659 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 483179008660 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 483179008661 Transcriptional regulators [Transcription]; Region: MarR; COG1846 483179008662 MarR family; Region: MarR; pfam01047 483179008663 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 483179008664 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 483179008665 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483179008666 putative substrate translocation pore; other site 483179008667 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 483179008668 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 483179008669 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 483179008670 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 483179008671 DNA binding site [nucleotide binding] 483179008672 active site 483179008673 tartrate dehydrogenase; Region: TTC; TIGR02089 483179008674 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 483179008675 Uncharacterized conserved protein [Function unknown]; Region: COG2835 483179008676 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 483179008677 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 483179008678 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 483179008679 catalytic residues [active] 483179008680 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 483179008681 putative deacylase active site [active] 483179008682 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 483179008683 apolar tunnel; other site 483179008684 heme binding site [chemical binding]; other site 483179008685 dimerization interface [polypeptide binding]; other site 483179008686 ornithine cyclodeaminase; Validated; Region: PRK07589 483179008687 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 483179008688 Arginase family; Region: Arginase; cd09989 483179008689 agmatinase; Region: agmatinase; TIGR01230 483179008690 active site 483179008691 Mn binding site [ion binding]; other site 483179008692 oligomer interface [polypeptide binding]; other site 483179008693 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 483179008694 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 483179008695 AsnC family; Region: AsnC_trans_reg; pfam01037 483179008696 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 483179008697 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 483179008698 FMN binding site [chemical binding]; other site 483179008699 active site 483179008700 substrate binding site [chemical binding]; other site 483179008701 catalytic residue [active] 483179008702 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 483179008703 dimerization interface [polypeptide binding]; other site 483179008704 putative DNA binding site [nucleotide binding]; other site 483179008705 putative Zn2+ binding site [ion binding]; other site 483179008706 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 483179008707 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 483179008708 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 483179008709 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 483179008710 RNA binding site [nucleotide binding]; other site 483179008711 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 483179008712 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 483179008713 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 483179008714 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 483179008715 putative Zn2+ binding site [ion binding]; other site 483179008716 putative DNA binding site [nucleotide binding]; other site 483179008717 dimerization interface [polypeptide binding]; other site 483179008718 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 483179008719 dimerization interface [polypeptide binding]; other site 483179008720 aldehyde dehydrogenase family 7 member; Region: PLN02315 483179008721 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 483179008722 tetrameric interface [polypeptide binding]; other site 483179008723 NAD binding site [chemical binding]; other site 483179008724 catalytic residues [active] 483179008725 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 483179008726 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 483179008727 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 483179008728 putative active site [active] 483179008729 putative substrate binding site [chemical binding]; other site 483179008730 putative cosubstrate binding site; other site 483179008731 catalytic site [active] 483179008732 hypothetical protein; Provisional; Region: PRK02947 483179008733 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 483179008734 putative active site [active] 483179008735 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 483179008736 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 483179008737 active site 483179008738 dimer interface [polypeptide binding]; other site 483179008739 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 483179008740 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 483179008741 dimer interface [polypeptide binding]; other site 483179008742 active site 483179008743 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 483179008744 dimer interface [polypeptide binding]; other site 483179008745 active site 483179008746 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 483179008747 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 483179008748 DNA-binding site [nucleotide binding]; DNA binding site 483179008749 UTRA domain; Region: UTRA; pfam07702 483179008750 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 483179008751 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 483179008752 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 483179008753 HlyD family secretion protein; Region: HlyD_3; pfam13437 483179008754 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 483179008755 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 483179008756 HlyD family secretion protein; Region: HlyD_3; pfam13437 483179008757 putative membrane fusion protein; Region: TIGR02828 483179008758 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 483179008759 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 483179008760 putative molybdopterin cofactor binding site [chemical binding]; other site 483179008761 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 483179008762 putative molybdopterin cofactor binding site; other site 483179008763 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 483179008764 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 483179008765 phosphate binding site [ion binding]; other site 483179008766 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 483179008767 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 483179008768 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 483179008769 putative DNA binding site [nucleotide binding]; other site 483179008770 putative Zn2+ binding site [ion binding]; other site 483179008771 AsnC family; Region: AsnC_trans_reg; pfam01037 483179008772 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 483179008773 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 483179008774 active site 483179008775 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 483179008776 dimer interface [polypeptide binding]; other site 483179008777 substrate binding site [chemical binding]; other site 483179008778 catalytic residues [active] 483179008779 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 483179008780 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 483179008781 hydroxyglutarate oxidase; Provisional; Region: PRK11728 483179008782 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 483179008783 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 483179008784 non-specific DNA binding site [nucleotide binding]; other site 483179008785 salt bridge; other site 483179008786 sequence-specific DNA binding site [nucleotide binding]; other site 483179008787 Cupin domain; Region: Cupin_2; pfam07883 483179008788 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 483179008789 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 483179008790 inhibitor-cofactor binding pocket; inhibition site 483179008791 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483179008792 catalytic residue [active] 483179008793 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 483179008794 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 483179008795 DNA-binding site [nucleotide binding]; DNA binding site 483179008796 UTRA domain; Region: UTRA; pfam07702 483179008797 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 483179008798 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 483179008799 active site 483179008800 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 483179008801 active sites [active] 483179008802 tetramer interface [polypeptide binding]; other site 483179008803 N-formylglutamate amidohydrolase; Region: hutG_amidohyd; TIGR02017 483179008804 urocanate hydratase; Provisional; Region: PRK05414 483179008805 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3758 483179008806 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 483179008807 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 483179008808 homodimer interface [polypeptide binding]; other site 483179008809 substrate-cofactor binding pocket; other site 483179008810 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483179008811 catalytic residue [active] 483179008812 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 483179008813 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 483179008814 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 483179008815 TM-ABC transporter signature motif; other site 483179008816 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 483179008817 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 483179008818 Walker A/P-loop; other site 483179008819 ATP binding site [chemical binding]; other site 483179008820 Q-loop/lid; other site 483179008821 ABC transporter signature motif; other site 483179008822 Walker B; other site 483179008823 D-loop; other site 483179008824 H-loop/switch region; other site 483179008825 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 483179008826 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 483179008827 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 483179008828 putative ligand binding site [chemical binding]; other site 483179008829 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 483179008830 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 483179008831 active site 483179008832 intersubunit interface [polypeptide binding]; other site 483179008833 catalytic residue [active] 483179008834 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 483179008835 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 483179008836 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 483179008837 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 483179008838 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 483179008839 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 483179008840 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 483179008841 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 483179008842 thiamine pyrophosphate protein; Validated; Region: PRK08199 483179008843 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 483179008844 PYR/PP interface [polypeptide binding]; other site 483179008845 dimer interface [polypeptide binding]; other site 483179008846 TPP binding site [chemical binding]; other site 483179008847 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 483179008848 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 483179008849 TPP-binding site [chemical binding]; other site 483179008850 D-aminopeptidase; Reviewed; Region: PRK13128 483179008851 Beta-lactamase; Region: Beta-lactamase; pfam00144 483179008852 D-aminopeptidase, domain B; Region: DAP_B; pfam07930 483179008853 D-aminopeptidase, domain C; Region: DAP_C; pfam07932 483179008854 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 483179008855 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 483179008856 substrate binding pocket [chemical binding]; other site 483179008857 membrane-bound complex binding site; other site 483179008858 hinge residues; other site 483179008859 hypothetical protein; Provisional; Region: PRK06148 483179008860 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 483179008861 active site 483179008862 substrate binding site [chemical binding]; other site 483179008863 ATP binding site [chemical binding]; other site 483179008864 Peptidase family M23; Region: Peptidase_M23; pfam01551 483179008865 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 483179008866 inhibitor-cofactor binding pocket; inhibition site 483179008867 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483179008868 catalytic residue [active] 483179008869 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 483179008870 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 483179008871 AsnC family; Region: AsnC_trans_reg; pfam01037 483179008872 Transcriptional regulator [Transcription]; Region: LysR; COG0583 483179008873 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 483179008874 LysR substrate binding domain; Region: LysR_substrate; pfam03466 483179008875 dimerization interface [polypeptide binding]; other site 483179008876 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 483179008877 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 483179008878 putative ligand binding site [chemical binding]; other site 483179008879 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 483179008880 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 483179008881 Walker A/P-loop; other site 483179008882 ATP binding site [chemical binding]; other site 483179008883 Q-loop/lid; other site 483179008884 ABC transporter signature motif; other site 483179008885 Walker B; other site 483179008886 D-loop; other site 483179008887 H-loop/switch region; other site 483179008888 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 483179008889 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 483179008890 Walker A/P-loop; other site 483179008891 ATP binding site [chemical binding]; other site 483179008892 Q-loop/lid; other site 483179008893 ABC transporter signature motif; other site 483179008894 Walker B; other site 483179008895 D-loop; other site 483179008896 H-loop/switch region; other site 483179008897 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 483179008898 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 483179008899 TM-ABC transporter signature motif; other site 483179008900 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 483179008901 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 483179008902 TM-ABC transporter signature motif; other site 483179008903 choline dehydrogenase; Validated; Region: PRK02106 483179008904 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 483179008905 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 483179008906 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 483179008907 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 483179008908 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 483179008909 Walker A/P-loop; other site 483179008910 ATP binding site [chemical binding]; other site 483179008911 Q-loop/lid; other site 483179008912 ABC transporter signature motif; other site 483179008913 Walker B; other site 483179008914 D-loop; other site 483179008915 H-loop/switch region; other site 483179008916 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 483179008917 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179008918 dimer interface [polypeptide binding]; other site 483179008919 conserved gate region; other site 483179008920 ABC-ATPase subunit interface; other site 483179008921 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 483179008922 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 483179008923 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 483179008924 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483179008925 TPR motif; other site 483179008926 binding surface 483179008927 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483179008928 binding surface 483179008929 TPR motif; other site 483179008930 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483179008931 binding surface 483179008932 TPR motif; other site 483179008933 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 483179008934 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 483179008935 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 483179008936 putative active site [active] 483179008937 putative catalytic site [active] 483179008938 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 483179008939 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 483179008940 motif II; other site 483179008941 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 483179008942 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 483179008943 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 483179008944 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 483179008945 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 483179008946 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 483179008947 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 483179008948 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 483179008949 ligand binding site [chemical binding]; other site 483179008950 homodimer interface [polypeptide binding]; other site 483179008951 NAD(P) binding site [chemical binding]; other site 483179008952 trimer interface B [polypeptide binding]; other site 483179008953 trimer interface A [polypeptide binding]; other site 483179008954 Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835 483179008955 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 483179008956 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 483179008957 Beta-lactamase; Region: Beta-lactamase; pfam00144 483179008958 PAS fold; Region: PAS_7; pfam12860 483179008959 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 483179008960 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 483179008961 metal binding site [ion binding]; metal-binding site 483179008962 active site 483179008963 I-site; other site 483179008964 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 483179008965 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 483179008966 classical (c) SDRs; Region: SDR_c; cd05233 483179008967 NAD(P) binding site [chemical binding]; other site 483179008968 active site 483179008969 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 483179008970 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 483179008971 putative ligand binding site [chemical binding]; other site 483179008972 NAD binding site [chemical binding]; other site 483179008973 catalytic site [active] 483179008974 Transcriptional regulators [Transcription]; Region: PurR; COG1609 483179008975 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 483179008976 DNA binding site [nucleotide binding] 483179008977 domain linker motif; other site 483179008978 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 483179008979 putative dimerization interface [polypeptide binding]; other site 483179008980 putative ligand binding site [chemical binding]; other site 483179008981 Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402 483179008982 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 483179008983 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 483179008984 P-loop, Walker A motif; other site 483179008985 Base recognition motif; other site 483179008986 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 483179008987 FOG: WD40 repeat [General function prediction only]; Region: COG2319 483179008988 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 483179008989 structural tetrad; other site 483179008990 Predicted esterase [General function prediction only]; Region: COG0400 483179008991 putative hydrolase; Provisional; Region: PRK11460 483179008992 TMAO/DMSO reductase; Reviewed; Region: PRK05363 483179008993 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 483179008994 Moco binding site; other site 483179008995 metal coordination site [ion binding]; other site 483179008996 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 483179008997 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 483179008998 homotrimer interaction site [polypeptide binding]; other site 483179008999 putative active site [active] 483179009000 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 483179009001 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 483179009002 TM-ABC transporter signature motif; other site 483179009003 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 483179009004 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 483179009005 TM-ABC transporter signature motif; other site 483179009006 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 483179009007 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 483179009008 Walker A/P-loop; other site 483179009009 ATP binding site [chemical binding]; other site 483179009010 Q-loop/lid; other site 483179009011 ABC transporter signature motif; other site 483179009012 Walker B; other site 483179009013 D-loop; other site 483179009014 H-loop/switch region; other site 483179009015 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 483179009016 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 483179009017 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 483179009018 putative ligand binding site [chemical binding]; other site 483179009019 Transcriptional regulator [Transcription]; Region: IclR; COG1414 483179009020 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 483179009021 Bacterial transcriptional regulator; Region: IclR; pfam01614 483179009022 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 483179009023 dimer interface [polypeptide binding]; other site 483179009024 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 483179009025 metal binding site [ion binding]; metal-binding site 483179009026 glutathionine S-transferase; Provisional; Region: PRK10542 483179009027 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 483179009028 C-terminal domain interface [polypeptide binding]; other site 483179009029 GSH binding site (G-site) [chemical binding]; other site 483179009030 dimer interface [polypeptide binding]; other site 483179009031 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 483179009032 dimer interface [polypeptide binding]; other site 483179009033 N-terminal domain interface [polypeptide binding]; other site 483179009034 substrate binding pocket (H-site) [chemical binding]; other site 483179009035 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 483179009036 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 483179009037 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 483179009038 metal binding site [ion binding]; metal-binding site 483179009039 active site 483179009040 I-site; other site 483179009041 Predicted dehydrogenase [General function prediction only]; Region: COG0579 483179009042 hydroxyglutarate oxidase; Provisional; Region: PRK11728 483179009043 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 483179009044 DNA polymerase III subunit epsilon; Validated; Region: PRK09182 483179009045 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 483179009046 active site 483179009047 catalytic site [active] 483179009048 substrate binding site [chemical binding]; other site 483179009049 amidase; Provisional; Region: PRK07042 483179009050 Amidase; Region: Amidase; cl11426 483179009051 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 483179009052 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 483179009053 Walker A/P-loop; other site 483179009054 ATP binding site [chemical binding]; other site 483179009055 Q-loop/lid; other site 483179009056 ABC transporter signature motif; other site 483179009057 Walker B; other site 483179009058 D-loop; other site 483179009059 H-loop/switch region; other site 483179009060 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 483179009061 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 483179009062 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 483179009063 Walker A/P-loop; other site 483179009064 ATP binding site [chemical binding]; other site 483179009065 Q-loop/lid; other site 483179009066 ABC transporter signature motif; other site 483179009067 Walker B; other site 483179009068 D-loop; other site 483179009069 H-loop/switch region; other site 483179009070 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 483179009071 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 483179009072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179009073 dimer interface [polypeptide binding]; other site 483179009074 conserved gate region; other site 483179009075 putative PBP binding loops; other site 483179009076 ABC-ATPase subunit interface; other site 483179009077 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 483179009078 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179009079 dimer interface [polypeptide binding]; other site 483179009080 conserved gate region; other site 483179009081 putative PBP binding loops; other site 483179009082 ABC-ATPase subunit interface; other site 483179009083 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 483179009084 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 483179009085 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345 483179009086 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 483179009087 putative NAD(P) binding site [chemical binding]; other site 483179009088 active site 483179009089 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 483179009090 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 483179009091 NAD(P) binding site [chemical binding]; other site 483179009092 catalytic residues [active] 483179009093 catalytic residues [active] 483179009094 Transcriptional regulators [Transcription]; Region: GntR; COG1802 483179009095 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 483179009096 DNA-binding site [nucleotide binding]; DNA binding site 483179009097 FCD domain; Region: FCD; pfam07729 483179009098 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483179009099 Major Facilitator Superfamily; Region: MFS_1; pfam07690 483179009100 putative substrate translocation pore; other site 483179009101 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483179009102 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 483179009103 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 483179009104 homotrimer interaction site [polypeptide binding]; other site 483179009105 putative active site [active] 483179009106 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 483179009107 ribonuclease P; Reviewed; Region: rnpA; PRK01313 483179009108 membrane protein insertase; Provisional; Region: PRK01318 483179009109 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 483179009110 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 483179009111 G1 box; other site 483179009112 GTP/Mg2+ binding site [chemical binding]; other site 483179009113 Switch I region; other site 483179009114 G2 box; other site 483179009115 G3 box; other site 483179009116 Switch II region; other site 483179009117 G4 box; other site 483179009118 G5 box; other site 483179009119 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 483179009120 homohexameric interface [polypeptide binding]; other site 483179009121 feedback inhibition sensing region; other site 483179009122 nucleotide binding site [chemical binding]; other site 483179009123 N-acetyl-L-glutamate binding site [chemical binding]; other site 483179009124 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 483179009125 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 483179009126 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 483179009127 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 483179009128 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 483179009129 trimer interface [polypeptide binding]; other site 483179009130 active site 483179009131 substrate binding site [chemical binding]; other site 483179009132 CoA binding site [chemical binding]; other site 483179009133 Predicted transglutaminase-like cysteine proteinase [General function prediction only]; Region: COG3672 483179009134 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 483179009135 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 483179009136 metal binding site [ion binding]; metal-binding site 483179009137 dimer interface [polypeptide binding]; other site 483179009138 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 483179009139 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 483179009140 dimerization interface 3.5A [polypeptide binding]; other site 483179009141 active site 483179009142 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 483179009143 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 483179009144 putative active site [active] 483179009145 substrate binding site [chemical binding]; other site 483179009146 putative cosubstrate binding site; other site 483179009147 catalytic site [active] 483179009148 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 483179009149 substrate binding site [chemical binding]; other site 483179009150 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 483179009151 active site 483179009152 catalytic residues [active] 483179009153 metal binding site [ion binding]; metal-binding site 483179009154 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 483179009155 RmuC family; Region: RmuC; pfam02646 483179009156 Uncharacterized protein conserved in bacteria [Posttranslational modification, protein turnover, chaperones]; Region: COG3526 483179009157 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 483179009158 GIY-YIG motif/motif A; other site 483179009159 putative active site [active] 483179009160 putative metal binding site [ion binding]; other site 483179009161 GTP-binding protein LepA; Provisional; Region: PRK05433 483179009162 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 483179009163 G1 box; other site 483179009164 putative GEF interaction site [polypeptide binding]; other site 483179009165 GTP/Mg2+ binding site [chemical binding]; other site 483179009166 Switch I region; other site 483179009167 G2 box; other site 483179009168 G3 box; other site 483179009169 Switch II region; other site 483179009170 G4 box; other site 483179009171 G5 box; other site 483179009172 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 483179009173 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 483179009174 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 483179009175 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 483179009176 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 483179009177 putative NAD(P) binding site [chemical binding]; other site 483179009178 active site 483179009179 Undecaprenyl pyrophosphate phosphatase [Lipid transport and metabolism]; Region: BacA; COG1968 483179009180 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 483179009181 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 483179009182 C-terminal domain interface [polypeptide binding]; other site 483179009183 GSH binding site (G-site) [chemical binding]; other site 483179009184 dimer interface [polypeptide binding]; other site 483179009185 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 483179009186 N-terminal domain interface [polypeptide binding]; other site 483179009187 dimer interface [polypeptide binding]; other site 483179009188 substrate binding pocket (H-site) [chemical binding]; other site 483179009189 epoxyqueuosine reductase; Region: TIGR00276 483179009190 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 483179009191 HEAT repeat; Region: HEAT; pfam02985 483179009192 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 483179009193 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 483179009194 putative NAD(P) binding site [chemical binding]; other site 483179009195 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 483179009196 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 483179009197 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 483179009198 active site 483179009199 dimer interfaces [polypeptide binding]; other site 483179009200 catalytic residues [active] 483179009201 Glucokinase [Carbohydrate transport and metabolism]; Region: Glk; COG0837 483179009202 glucokinase, proteobacterial type; Region: glk; TIGR00749 483179009203 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 483179009204 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 483179009205 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 483179009206 Walker A/P-loop; other site 483179009207 ATP binding site [chemical binding]; other site 483179009208 Q-loop/lid; other site 483179009209 ABC transporter signature motif; other site 483179009210 Walker B; other site 483179009211 D-loop; other site 483179009212 H-loop/switch region; other site 483179009213 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 483179009214 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 483179009215 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 483179009216 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 483179009217 catalytic core [active] 483179009218 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 483179009219 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 483179009220 active site 483179009221 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 483179009222 putative FMN binding site [chemical binding]; other site 483179009223 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 483179009224 Ligand Binding Site [chemical binding]; other site 483179009225 Predicted membrane protein [Function unknown]; Region: COG3714 483179009226 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 483179009227 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 483179009228 NAD(P) binding site [chemical binding]; other site 483179009229 catalytic residues [active] 483179009230 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 483179009231 putative catalytic site [active] 483179009232 putative metal binding site [ion binding]; other site 483179009233 putative phosphate binding site [ion binding]; other site 483179009234 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 483179009235 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 483179009236 putative active site [active] 483179009237 catalytic site [active] 483179009238 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 483179009239 putative active site [active] 483179009240 catalytic site [active] 483179009241 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 483179009242 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 483179009243 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 483179009244 G1 box; other site 483179009245 putative GEF interaction site [polypeptide binding]; other site 483179009246 GTP/Mg2+ binding site [chemical binding]; other site 483179009247 Switch I region; other site 483179009248 G2 box; other site 483179009249 G3 box; other site 483179009250 Switch II region; other site 483179009251 G4 box; other site 483179009252 G5 box; other site 483179009253 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 483179009254 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 483179009255 Flavoprotein; Region: Flavoprotein; pfam02441 483179009256 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 483179009257 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 483179009258 ABC1 family; Region: ABC1; pfam03109 483179009259 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 483179009260 active site 483179009261 ATP binding site [chemical binding]; other site 483179009262 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 483179009263 substrate binding site [chemical binding]; other site 483179009264 activation loop (A-loop); other site 483179009265 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 483179009266 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483179009267 S-adenosylmethionine binding site [chemical binding]; other site 483179009268 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 483179009269 active site 483179009270 hypothetical protein; Provisional; Region: PRK00736 483179009271 methionine sulfoxide reductase A; Provisional; Region: PRK00058 483179009272 putative transposase OrfB; Reviewed; Region: PHA02517 483179009273 HTH-like domain; Region: HTH_21; pfam13276 483179009274 Integrase core domain; Region: rve; pfam00665 483179009275 Integrase core domain; Region: rve_3; pfam13683 483179009276 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 483179009277 Transposase; Region: HTH_Tnp_1; pfam01527 483179009278 Transcriptional regulators [Transcription]; Region: GntR; COG1802 483179009279 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 483179009280 DNA-binding site [nucleotide binding]; DNA binding site 483179009281 FCD domain; Region: FCD; pfam07729 483179009282 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 483179009283 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 483179009284 tetramerization interface [polypeptide binding]; other site 483179009285 NAD(P) binding site [chemical binding]; other site 483179009286 catalytic residues [active] 483179009287 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 483179009288 CoA-transferase family III; Region: CoA_transf_3; pfam02515 483179009289 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 483179009290 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 483179009291 Walker A/P-loop; other site 483179009292 ATP binding site [chemical binding]; other site 483179009293 Q-loop/lid; other site 483179009294 ABC transporter signature motif; other site 483179009295 Walker B; other site 483179009296 D-loop; other site 483179009297 H-loop/switch region; other site 483179009298 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 483179009299 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 483179009300 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 483179009301 Walker A/P-loop; other site 483179009302 ATP binding site [chemical binding]; other site 483179009303 Q-loop/lid; other site 483179009304 ABC transporter signature motif; other site 483179009305 Walker B; other site 483179009306 D-loop; other site 483179009307 H-loop/switch region; other site 483179009308 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 483179009309 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 483179009310 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179009311 dimer interface [polypeptide binding]; other site 483179009312 conserved gate region; other site 483179009313 putative PBP binding loops; other site 483179009314 ABC-ATPase subunit interface; other site 483179009315 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 483179009316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179009317 dimer interface [polypeptide binding]; other site 483179009318 conserved gate region; other site 483179009319 putative PBP binding loops; other site 483179009320 ABC-ATPase subunit interface; other site 483179009321 Transcriptional regulator [Transcription]; Region: IclR; COG1414 483179009322 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 483179009323 Bacterial transcriptional regulator; Region: IclR; pfam01614 483179009324 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 483179009325 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 483179009326 E3 interaction surface; other site 483179009327 lipoyl attachment site [posttranslational modification]; other site 483179009328 e3 binding domain; Region: E3_binding; pfam02817 483179009329 Serine hydrolase; Region: Ser_hydrolase; cl17834 483179009330 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 483179009331 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 483179009332 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 483179009333 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 483179009334 tetramer interface [polypeptide binding]; other site 483179009335 TPP-binding site [chemical binding]; other site 483179009336 heterodimer interface [polypeptide binding]; other site 483179009337 phosphorylation loop region [posttranslational modification] 483179009338 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 483179009339 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 483179009340 alpha subunit interface [polypeptide binding]; other site 483179009341 TPP binding site [chemical binding]; other site 483179009342 heterodimer interface [polypeptide binding]; other site 483179009343 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 483179009344 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 483179009345 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 483179009346 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 483179009347 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 483179009348 enoyl-CoA hydratase; Provisional; Region: PRK08138 483179009349 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 483179009350 substrate binding site [chemical binding]; other site 483179009351 oxyanion hole (OAH) forming residues; other site 483179009352 trimer interface [polypeptide binding]; other site 483179009353 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 483179009354 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 483179009355 active site 483179009356 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 483179009357 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 483179009358 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 483179009359 active site 483179009360 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 483179009361 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 483179009362 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 483179009363 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 483179009364 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179009365 dimer interface [polypeptide binding]; other site 483179009366 conserved gate region; other site 483179009367 putative PBP binding loops; other site 483179009368 ABC-ATPase subunit interface; other site 483179009369 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 483179009370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179009371 dimer interface [polypeptide binding]; other site 483179009372 conserved gate region; other site 483179009373 putative PBP binding loops; other site 483179009374 ABC-ATPase subunit interface; other site 483179009375 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 483179009376 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 483179009377 Walker A/P-loop; other site 483179009378 ATP binding site [chemical binding]; other site 483179009379 Q-loop/lid; other site 483179009380 ABC transporter signature motif; other site 483179009381 Walker B; other site 483179009382 D-loop; other site 483179009383 H-loop/switch region; other site 483179009384 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 483179009385 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 483179009386 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 483179009387 Walker A/P-loop; other site 483179009388 ATP binding site [chemical binding]; other site 483179009389 Q-loop/lid; other site 483179009390 ABC transporter signature motif; other site 483179009391 Walker B; other site 483179009392 D-loop; other site 483179009393 H-loop/switch region; other site 483179009394 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 483179009395 Transcriptional regulators [Transcription]; Region: GntR; COG1802 483179009396 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 483179009397 DNA-binding site [nucleotide binding]; DNA binding site 483179009398 FCD domain; Region: FCD; pfam07729 483179009399 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 483179009400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179009401 dimer interface [polypeptide binding]; other site 483179009402 conserved gate region; other site 483179009403 putative PBP binding loops; other site 483179009404 ABC-ATPase subunit interface; other site 483179009405 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 483179009406 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179009407 dimer interface [polypeptide binding]; other site 483179009408 conserved gate region; other site 483179009409 putative PBP binding loops; other site 483179009410 ABC-ATPase subunit interface; other site 483179009411 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 483179009412 amidase; Provisional; Region: PRK07486 483179009413 Amidase; Region: Amidase; cl11426 483179009414 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 483179009415 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 483179009416 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 483179009417 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179009418 dimer interface [polypeptide binding]; other site 483179009419 conserved gate region; other site 483179009420 putative PBP binding loops; other site 483179009421 ABC-ATPase subunit interface; other site 483179009422 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179009423 dimer interface [polypeptide binding]; other site 483179009424 conserved gate region; other site 483179009425 putative PBP binding loops; other site 483179009426 ABC-ATPase subunit interface; other site 483179009427 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 483179009428 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 483179009429 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 483179009430 catalytic residue [active] 483179009431 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235 483179009432 intersubunit interface [polypeptide binding]; other site 483179009433 active site 483179009434 Zn2+ binding site [ion binding]; other site 483179009435 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 483179009436 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 483179009437 putative transposase OrfB; Reviewed; Region: PHA02517 483179009438 HTH-like domain; Region: HTH_21; pfam13276 483179009439 Integrase core domain; Region: rve; pfam00665 483179009440 Integrase core domain; Region: rve_3; pfam13683 483179009441 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 483179009442 Rrf2 family protein; Region: rrf2_super; TIGR00738 483179009443 Transcriptional regulator; Region: Rrf2; pfam02082 483179009444 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 483179009445 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 483179009446 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 483179009447 ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531 483179009448 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 483179009449 metal binding site [ion binding]; metal-binding site 483179009450 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 483179009451 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 483179009452 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 483179009453 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 483179009454 ABC-ATPase subunit interface; other site 483179009455 dimer interface [polypeptide binding]; other site 483179009456 putative PBP binding regions; other site 483179009457 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 483179009458 metal binding site 2 [ion binding]; metal-binding site 483179009459 putative DNA binding helix; other site 483179009460 metal binding site 1 [ion binding]; metal-binding site 483179009461 dimer interface [polypeptide binding]; other site 483179009462 structural Zn2+ binding site [ion binding]; other site 483179009463 Rod binding protein; Region: Rod-binding; pfam10135 483179009464 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 483179009465 flagellar biosynthesis protein FlhA; Reviewed; Region: flhA; PRK12792 483179009466 FHIPEP family; Region: FHIPEP; pfam00771 483179009467 flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010 483179009468 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009 483179009469 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 483179009470 Flagellar biosynthesis regulator FlbT [Cell motility and secretion]; Region: FlbT; COG5443 483179009471 Flagellar biosynthesis regulator FlaF [Cell motility and secretion]; Region: FlaF; COG5442 483179009472 flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793 483179009473 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008 483179009474 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 483179009475 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 483179009476 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 483179009477 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 483179009478 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 483179009479 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 483179009480 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 483179009481 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 483179009482 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 483179009483 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 483179009484 DNA binding site [nucleotide binding] 483179009485 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 483179009486 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 483179009487 N-acetyl-D-glucosamine binding site [chemical binding]; other site 483179009488 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 483179009489 chemotaxis protein; Reviewed; Region: PRK12798 483179009490 flagellar motor protein MotB; Validated; Region: motB; PRK05996 483179009491 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 483179009492 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 483179009493 ligand binding site [chemical binding]; other site 483179009494 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 483179009495 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 483179009496 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 483179009497 flagellin; Reviewed; Region: PRK12687 483179009498 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 483179009499 Uncharacterized conserved protein [Function unknown]; Region: COG3268 483179009500 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 483179009501 D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634 483179009502 putative ligand binding site [chemical binding]; other site 483179009503 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 483179009504 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 483179009505 Walker A/P-loop; other site 483179009506 ATP binding site [chemical binding]; other site 483179009507 Q-loop/lid; other site 483179009508 ABC transporter signature motif; other site 483179009509 Walker B; other site 483179009510 D-loop; other site 483179009511 H-loop/switch region; other site 483179009512 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 483179009513 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 483179009514 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 483179009515 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 483179009516 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 483179009517 TM-ABC transporter signature motif; other site 483179009518 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 483179009519 HTH domain; Region: HTH_11; cl17392 483179009520 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 483179009521 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 483179009522 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 483179009523 NAD(P) binding site [chemical binding]; other site 483179009524 catalytic residues [active] 483179009525 choline dehydrogenase; Validated; Region: PRK02106 483179009526 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Region: HpaI; TIGR02311 483179009527 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 483179009528 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 483179009529 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 483179009530 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 483179009531 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 483179009532 NAD binding site [chemical binding]; other site 483179009533 catalytic residues [active] 483179009534 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 483179009535 putative substrate binding pocket [chemical binding]; other site 483179009536 trimer interface [polypeptide binding]; other site 483179009537 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 483179009538 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 483179009539 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 483179009540 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 483179009541 active site 483179009542 ATP binding site [chemical binding]; other site 483179009543 substrate binding site [chemical binding]; other site 483179009544 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 483179009545 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 483179009546 inhibitor-cofactor binding pocket; inhibition site 483179009547 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483179009548 catalytic residue [active] 483179009549 hypothetical protein; Provisional; Region: PRK07481 483179009550 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 483179009551 inhibitor-cofactor binding pocket; inhibition site 483179009552 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483179009553 catalytic residue [active] 483179009554 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 483179009555 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 483179009556 motif II; other site 483179009557 Uncharacterized conserved protein [Function unknown]; Region: COG5441; cl02262 483179009558 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 483179009559 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 483179009560 Transcriptional regulator [Transcription]; Region: IclR; COG1414 483179009561 Bacterial transcriptional regulator; Region: IclR; pfam01614 483179009562 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 483179009563 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 483179009564 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 483179009565 NAD(P) binding site [chemical binding]; other site 483179009566 catalytic residues [active] 483179009567 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 483179009568 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 483179009569 active site 483179009570 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 483179009571 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 483179009572 putative ligand binding site [chemical binding]; other site 483179009573 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 483179009574 TM-ABC transporter signature motif; other site 483179009575 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 483179009576 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 483179009577 TM-ABC transporter signature motif; other site 483179009578 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 483179009579 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 483179009580 Walker A/P-loop; other site 483179009581 ATP binding site [chemical binding]; other site 483179009582 Q-loop/lid; other site 483179009583 ABC transporter signature motif; other site 483179009584 Walker B; other site 483179009585 D-loop; other site 483179009586 H-loop/switch region; other site 483179009587 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 483179009588 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 483179009589 Walker A/P-loop; other site 483179009590 ATP binding site [chemical binding]; other site 483179009591 Q-loop/lid; other site 483179009592 ABC transporter signature motif; other site 483179009593 Walker B; other site 483179009594 D-loop; other site 483179009595 H-loop/switch region; other site 483179009596 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 483179009597 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 483179009598 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 483179009599 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 483179009600 DNA-binding site [nucleotide binding]; DNA binding site 483179009601 UTRA domain; Region: UTRA; pfam07702 483179009602 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 483179009603 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 483179009604 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 483179009605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179009606 dimer interface [polypeptide binding]; other site 483179009607 conserved gate region; other site 483179009608 putative PBP binding loops; other site 483179009609 ABC-ATPase subunit interface; other site 483179009610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179009611 dimer interface [polypeptide binding]; other site 483179009612 conserved gate region; other site 483179009613 putative PBP binding loops; other site 483179009614 ABC-ATPase subunit interface; other site 483179009615 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 483179009616 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483179009617 Walker A/P-loop; other site 483179009618 ATP binding site [chemical binding]; other site 483179009619 Q-loop/lid; other site 483179009620 ABC transporter signature motif; other site 483179009621 Walker B; other site 483179009622 D-loop; other site 483179009623 H-loop/switch region; other site 483179009624 TOBE domain; Region: TOBE_2; pfam08402 483179009625 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 483179009626 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 483179009627 active site 483179009628 metal binding site [ion binding]; metal-binding site 483179009629 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 483179009630 Sulfatase; Region: Sulfatase; cl17466 483179009631 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 483179009632 NMT1-like family; Region: NMT1_2; pfam13379 483179009633 substrate binding pocket [chemical binding]; other site 483179009634 membrane-bound complex binding site; other site 483179009635 hinge residues; other site 483179009636 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 483179009637 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 483179009638 Walker A/P-loop; other site 483179009639 ATP binding site [chemical binding]; other site 483179009640 Q-loop/lid; other site 483179009641 ABC transporter signature motif; other site 483179009642 Walker B; other site 483179009643 D-loop; other site 483179009644 H-loop/switch region; other site 483179009645 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 483179009646 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483179009647 dimer interface [polypeptide binding]; other site 483179009648 conserved gate region; other site 483179009649 putative PBP binding loops; other site 483179009650 ABC-ATPase subunit interface; other site 483179009651 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 483179009652 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 483179009653 nucleotide binding site [chemical binding]; other site 483179009654 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 483179009655 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 483179009656 N-terminal plug; other site 483179009657 ligand-binding site [chemical binding]; other site 483179009658 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 483179009659 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 483179009660 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 483179009661 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_5; cd06338 483179009662 putative ligand binding site [chemical binding]; other site 483179009663 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 483179009664 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 483179009665 TM-ABC transporter signature motif; other site 483179009666 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 483179009667 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 483179009668 Walker A/P-loop; other site 483179009669 ATP binding site [chemical binding]; other site 483179009670 Q-loop/lid; other site 483179009671 ABC transporter signature motif; other site 483179009672 Walker B; other site 483179009673 D-loop; other site 483179009674 H-loop/switch region; other site 483179009675 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 483179009676 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 483179009677 Walker A/P-loop; other site 483179009678 ATP binding site [chemical binding]; other site 483179009679 Q-loop/lid; other site 483179009680 ABC transporter signature motif; other site 483179009681 Walker B; other site 483179009682 D-loop; other site 483179009683 H-loop/switch region; other site 483179009684 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 483179009685 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 483179009686 FeS/SAM binding site; other site 483179009687 HemN C-terminal domain; Region: HemN_C; pfam06969 483179009688 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 483179009689 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 483179009690 P-loop; other site 483179009691 Magnesium ion binding site [ion binding]; other site 483179009692 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 483179009693 P-loop; other site 483179009694 Magnesium ion binding site [ion binding]; other site 483179009695 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 483179009696 ParB-like nuclease domain; Region: ParB; smart00470