-- dump date 20140619_010816 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1423891000001 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1423891000002 substrate binding site [chemical binding]; other site 1423891000003 active site 1423891000004 Predicted membrane protein [Function unknown]; Region: COG1981 1423891000005 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1423891000006 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1423891000007 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1423891000008 RNA binding site [nucleotide binding]; other site 1423891000009 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1423891000010 multimer interface [polypeptide binding]; other site 1423891000011 Walker A motif; other site 1423891000012 ATP binding site [chemical binding]; other site 1423891000013 Walker B motif; other site 1423891000014 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1423891000015 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1423891000016 catalytic residues [active] 1423891000017 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1423891000018 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 1423891000019 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1423891000020 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 1423891000021 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1423891000022 G1 box; other site 1423891000023 G1 box; other site 1423891000024 GTP/Mg2+ binding site [chemical binding]; other site 1423891000025 GTP/Mg2+ binding site [chemical binding]; other site 1423891000026 Switch I region; other site 1423891000027 Switch I region; other site 1423891000028 G2 box; other site 1423891000029 G2 box; other site 1423891000030 Switch II region; other site 1423891000031 G3 box; other site 1423891000032 G4 box; other site 1423891000033 G5 box; other site 1423891000034 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1423891000035 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1423891000036 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1423891000037 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1423891000038 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1423891000039 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1423891000040 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1423891000041 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1423891000042 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1423891000043 P-loop; other site 1423891000044 Magnesium ion binding site [ion binding]; other site 1423891000045 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1423891000046 Magnesium ion binding site [ion binding]; other site 1423891000047 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1423891000048 ParB-like nuclease domain; Region: ParB; smart00470 1423891000049 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 1423891000050 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1423891000051 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 1423891000052 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1423891000053 Walker A/P-loop; other site 1423891000054 ATP binding site [chemical binding]; other site 1423891000055 Q-loop/lid; other site 1423891000056 ABC transporter signature motif; other site 1423891000057 Walker B; other site 1423891000058 D-loop; other site 1423891000059 H-loop/switch region; other site 1423891000060 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1423891000061 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 1423891000062 TM-ABC transporter signature motif; other site 1423891000063 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 1423891000064 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1423891000065 zinc binding site [ion binding]; other site 1423891000066 putative ligand binding site [chemical binding]; other site 1423891000067 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1423891000068 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1423891000069 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1423891000070 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1423891000071 DNA binding site [nucleotide binding] 1423891000072 domain linker motif; other site 1423891000073 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 1423891000074 putative dimerization interface [polypeptide binding]; other site 1423891000075 putative ligand binding site [chemical binding]; other site 1423891000076 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1423891000077 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1423891000078 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1423891000079 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 1423891000080 Coenzyme A transferase; Region: CoA_trans; smart00882 1423891000081 Coenzyme A transferase; Region: CoA_trans; cl17247 1423891000082 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1423891000083 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1423891000084 substrate binding site [chemical binding]; other site 1423891000085 oxyanion hole (OAH) forming residues; other site 1423891000086 trimer interface [polypeptide binding]; other site 1423891000087 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1423891000088 Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118 1423891000089 NAD(P) binding site [chemical binding]; other site 1423891000090 catalytic residues [active] 1423891000091 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1423891000092 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1423891000093 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 1423891000094 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1423891000095 NAD(P) binding site [chemical binding]; other site 1423891000096 active site 1423891000097 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 1423891000098 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1423891000099 Domain of unknown function (DUF4354); Region: DUF4354; pfam14263 1423891000100 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1423891000101 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1423891000102 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1423891000103 NAD(P) binding site [chemical binding]; other site 1423891000104 active site 1423891000105 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1423891000106 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1423891000107 metal binding site [ion binding]; metal-binding site 1423891000108 putative dimer interface [polypeptide binding]; other site 1423891000109 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1423891000110 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1423891000111 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1423891000112 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1423891000113 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1423891000114 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1423891000115 CPxP motif; other site 1423891000116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 1423891000117 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1423891000118 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1423891000119 active site 1423891000120 DNA binding site [nucleotide binding] 1423891000121 Int/Topo IB signature motif; other site 1423891000122 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 1423891000123 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1423891000124 ADP binding site [chemical binding]; other site 1423891000125 magnesium binding site [ion binding]; other site 1423891000126 putative shikimate binding site; other site 1423891000127 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1423891000128 active site 1423891000129 dimer interface [polypeptide binding]; other site 1423891000130 metal binding site [ion binding]; metal-binding site 1423891000131 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 1423891000132 Domain of unknown function DUF21; Region: DUF21; pfam01595 1423891000133 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1423891000134 Transporter associated domain; Region: CorC_HlyC; smart01091 1423891000135 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 1423891000136 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 1423891000137 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1423891000138 HSP70 interaction site [polypeptide binding]; other site 1423891000139 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 1423891000140 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 1423891000141 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1423891000142 Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase) [Coenzyme metabolism]; Region: CobT; COG4547 1423891000143 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 1423891000144 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1423891000145 metal ion-dependent adhesion site (MIDAS); other site 1423891000146 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1423891000147 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1423891000148 metal-binding site [ion binding] 1423891000149 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1423891000150 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1423891000151 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 1423891000152 DNA binding residues [nucleotide binding] 1423891000153 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 1423891000154 dimer interface [polypeptide binding]; other site 1423891000155 putative metal binding site [ion binding]; other site 1423891000156 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1423891000157 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 1423891000158 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 1423891000159 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1423891000160 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1423891000161 active site 1423891000162 phosphorylation site [posttranslational modification] 1423891000163 intermolecular recognition site; other site 1423891000164 dimerization interface [polypeptide binding]; other site 1423891000165 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1423891000166 DNA binding site [nucleotide binding] 1423891000167 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1423891000168 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1423891000169 ligand binding site [chemical binding]; other site 1423891000170 flexible hinge region; other site 1423891000171 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1423891000172 putative catalytic site [active] 1423891000173 putative phosphate binding site [ion binding]; other site 1423891000174 active site 1423891000175 metal binding site A [ion binding]; metal-binding site 1423891000176 DNA binding site [nucleotide binding] 1423891000177 putative AP binding site [nucleotide binding]; other site 1423891000178 putative metal binding site B [ion binding]; other site 1423891000179 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 1423891000180 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 1423891000181 aquaporin Z; Provisional; Region: PRK05420 1423891000182 amphipathic channel; other site 1423891000183 Asn-Pro-Ala signature motifs; other site 1423891000184 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1423891000185 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1423891000186 Walker A/P-loop; other site 1423891000187 ATP binding site [chemical binding]; other site 1423891000188 Q-loop/lid; other site 1423891000189 ABC transporter signature motif; other site 1423891000190 Walker B; other site 1423891000191 D-loop; other site 1423891000192 H-loop/switch region; other site 1423891000193 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1423891000194 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1423891000195 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1423891000196 putative acyl-acceptor binding pocket; other site 1423891000197 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1423891000198 dimer interface [polypeptide binding]; other site 1423891000199 substrate binding site [chemical binding]; other site 1423891000200 metal binding sites [ion binding]; metal-binding site 1423891000201 YGGT family; Region: YGGT; pfam02325 1423891000202 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 1423891000203 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1423891000204 putative active site pocket [active] 1423891000205 dimerization interface [polypeptide binding]; other site 1423891000206 putative catalytic residue [active] 1423891000207 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 1423891000208 prephenate dehydrogenase; Validated; Region: PRK08507 1423891000209 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1423891000210 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1423891000211 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1423891000212 homodimer interface [polypeptide binding]; other site 1423891000213 catalytic residue [active] 1423891000214 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1423891000215 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1423891000216 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1423891000217 active site 1423891000218 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1423891000219 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1423891000220 active site 1423891000221 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1423891000222 substrate binding site [chemical binding]; other site 1423891000223 catalytic residues [active] 1423891000224 dimer interface [polypeptide binding]; other site 1423891000225 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 1423891000226 argininosuccinate lyase; Provisional; Region: PRK00855 1423891000227 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1423891000228 active sites [active] 1423891000229 tetramer interface [polypeptide binding]; other site 1423891000230 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1423891000231 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1423891000232 catalytic residues [active] 1423891000233 hypothetical protein; Validated; Region: PRK00124 1423891000234 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1423891000235 short chain dehydrogenase; Provisional; Region: PRK05993 1423891000236 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1423891000237 NADP binding site [chemical binding]; other site 1423891000238 active site 1423891000239 steroid binding site; other site 1423891000240 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1423891000241 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1423891000242 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1423891000243 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 1423891000244 active site 1423891000245 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1423891000246 Ligand Binding Site [chemical binding]; other site 1423891000247 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1423891000248 Ligand binding site [chemical binding]; other site 1423891000249 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1423891000250 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1423891000251 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1423891000252 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1423891000253 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 1423891000254 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1423891000255 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1423891000256 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1423891000257 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1423891000258 dimer interface [polypeptide binding]; other site 1423891000259 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1423891000260 catalytic residue [active] 1423891000261 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1423891000262 Ligand Binding Site [chemical binding]; other site 1423891000263 methionine gamma-lyase; Validated; Region: PRK07049 1423891000264 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1423891000265 homodimer interface [polypeptide binding]; other site 1423891000266 substrate-cofactor binding pocket; other site 1423891000267 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1423891000268 catalytic residue [active] 1423891000269 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 1423891000270 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1423891000271 putative substrate translocation pore; other site 1423891000272 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1423891000273 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1423891000274 DNA-binding site [nucleotide binding]; DNA binding site 1423891000275 FCD domain; Region: FCD; pfam07729 1423891000276 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1423891000277 active site 1423891000278 homotetramer interface [polypeptide binding]; other site 1423891000279 homodimer interface [polypeptide binding]; other site 1423891000280 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1423891000281 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1423891000282 Walker A/P-loop; other site 1423891000283 ATP binding site [chemical binding]; other site 1423891000284 Q-loop/lid; other site 1423891000285 ABC transporter signature motif; other site 1423891000286 Walker B; other site 1423891000287 D-loop; other site 1423891000288 H-loop/switch region; other site 1423891000289 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1423891000290 Aspartase; Region: Aspartase; cd01357 1423891000291 active sites [active] 1423891000292 tetramer interface [polypeptide binding]; other site 1423891000293 agmatinase; Region: agmatinase; TIGR01230 1423891000294 Agmatinase and related proteins; Region: Agmatinase_like_1; cd11589 1423891000295 oligomer interface [polypeptide binding]; other site 1423891000296 active site 1423891000297 Mn binding site [ion binding]; other site 1423891000298 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1423891000299 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1423891000300 Walker A/P-loop; other site 1423891000301 ATP binding site [chemical binding]; other site 1423891000302 Q-loop/lid; other site 1423891000303 ABC transporter signature motif; other site 1423891000304 Walker B; other site 1423891000305 D-loop; other site 1423891000306 H-loop/switch region; other site 1423891000307 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1423891000308 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891000309 dimer interface [polypeptide binding]; other site 1423891000310 conserved gate region; other site 1423891000311 putative PBP binding loops; other site 1423891000312 ABC-ATPase subunit interface; other site 1423891000313 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1423891000314 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891000315 dimer interface [polypeptide binding]; other site 1423891000316 conserved gate region; other site 1423891000317 putative PBP binding loops; other site 1423891000318 ABC-ATPase subunit interface; other site 1423891000319 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1423891000320 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1423891000321 substrate binding pocket [chemical binding]; other site 1423891000322 membrane-bound complex binding site; other site 1423891000323 hinge residues; other site 1423891000324 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1423891000325 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1423891000326 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1423891000327 dimerization interface [polypeptide binding]; other site 1423891000328 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 1423891000329 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1423891000330 Sulfatase; Region: Sulfatase; pfam00884 1423891000331 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 1423891000332 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1423891000333 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1423891000334 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1423891000335 ATP binding site [chemical binding]; other site 1423891000336 putative Mg++ binding site [ion binding]; other site 1423891000337 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1423891000338 SEC-C motif; Region: SEC-C; pfam02810 1423891000339 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 1423891000340 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1423891000341 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1423891000342 heterotetramer interface [polypeptide binding]; other site 1423891000343 active site pocket [active] 1423891000344 cleavage site 1423891000345 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1423891000346 Coenzyme A binding pocket [chemical binding]; other site 1423891000347 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1423891000348 active site 1423891000349 8-oxo-dGMP binding site [chemical binding]; other site 1423891000350 nudix motif; other site 1423891000351 metal binding site [ion binding]; metal-binding site 1423891000352 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 1423891000353 intracellular septation protein A; Reviewed; Region: PRK00259 1423891000354 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1423891000355 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1423891000356 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1423891000357 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1423891000358 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 1423891000359 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1423891000360 FeS/SAM binding site; other site 1423891000361 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1423891000362 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1423891000363 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1423891000364 Protease inhibitor Inh; Region: Inh; pfam02974 1423891000365 Predicted ATPase [General function prediction only]; Region: COG1485 1423891000366 malate dehydrogenase; Reviewed; Region: PRK06223 1423891000367 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1423891000368 NAD(P) binding site [chemical binding]; other site 1423891000369 dimer interface [polypeptide binding]; other site 1423891000370 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1423891000371 substrate binding site [chemical binding]; other site 1423891000372 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1423891000373 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1423891000374 CoA-ligase; Region: Ligase_CoA; pfam00549 1423891000375 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1423891000376 CoA binding domain; Region: CoA_binding; smart00881 1423891000377 CoA-ligase; Region: Ligase_CoA; pfam00549 1423891000378 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1423891000379 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1423891000380 TPP-binding site [chemical binding]; other site 1423891000381 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1423891000382 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1423891000383 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1423891000384 E3 interaction surface; other site 1423891000385 lipoyl attachment site [posttranslational modification]; other site 1423891000386 e3 binding domain; Region: E3_binding; pfam02817 1423891000387 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1423891000388 Predicted membrane protein [Function unknown]; Region: COG3686 1423891000389 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1423891000390 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 1423891000391 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1423891000392 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1423891000393 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1423891000394 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 1423891000395 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1423891000396 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1423891000397 active site 1423891000398 DNA binding site [nucleotide binding] 1423891000399 Int/Topo IB signature motif; other site 1423891000400 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1423891000401 RimM N-terminal domain; Region: RimM; pfam01782 1423891000402 PRC-barrel domain; Region: PRC; pfam05239 1423891000403 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1423891000404 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1423891000405 dimerization interface [polypeptide binding]; other site 1423891000406 putative DNA binding site [nucleotide binding]; other site 1423891000407 putative Zn2+ binding site [ion binding]; other site 1423891000408 NIPSNAP; Region: NIPSNAP; pfam07978 1423891000409 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1423891000410 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1423891000411 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1423891000412 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1423891000413 substrate binding site [chemical binding]; other site 1423891000414 ligand binding site [chemical binding]; other site 1423891000415 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1423891000416 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1423891000417 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1423891000418 Coenzyme A binding pocket [chemical binding]; other site 1423891000419 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1423891000420 Iron-sulfur protein interface; other site 1423891000421 proximal quinone binding site [chemical binding]; other site 1423891000422 SdhD (CybS) interface [polypeptide binding]; other site 1423891000423 proximal heme binding site [chemical binding]; other site 1423891000424 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 1423891000425 putative SdhC subunit interface [polypeptide binding]; other site 1423891000426 putative proximal heme binding site [chemical binding]; other site 1423891000427 putative Iron-sulfur protein interface [polypeptide binding]; other site 1423891000428 putative proximal quinone binding site; other site 1423891000429 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 1423891000430 L-aspartate oxidase; Provisional; Region: PRK06175 1423891000431 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1423891000432 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1423891000433 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1423891000434 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1423891000435 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1423891000436 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333 1423891000437 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1423891000438 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1423891000439 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1423891000440 active site 1423891000441 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1423891000442 catalytic triad [active] 1423891000443 dimer interface [polypeptide binding]; other site 1423891000444 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1423891000445 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1423891000446 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1423891000447 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1423891000448 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1423891000449 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1423891000450 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1423891000451 DNA-binding site [nucleotide binding]; DNA binding site 1423891000452 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1423891000453 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1423891000454 homodimer interface [polypeptide binding]; other site 1423891000455 catalytic residue [active] 1423891000456 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1423891000457 EamA-like transporter family; Region: EamA; pfam00892 1423891000458 Predicted methyltransferase [General function prediction only]; Region: COG3897 1423891000459 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1423891000460 S-adenosylmethionine binding site [chemical binding]; other site 1423891000461 Uncharacterized conserved protein [Function unknown]; Region: COG2947 1423891000462 YciI-like protein; Reviewed; Region: PRK12863 1423891000463 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1423891000464 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1423891000465 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1423891000466 UGMP family protein; Validated; Region: PRK09604 1423891000467 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1423891000468 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1423891000469 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1423891000470 domain interfaces; other site 1423891000471 active site 1423891000472 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1423891000473 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1423891000474 active site 1423891000475 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223 1423891000476 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 1423891000477 HemY protein N-terminus; Region: HemY_N; pfam07219 1423891000478 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 1423891000479 putative metal binding site [ion binding]; other site 1423891000480 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1423891000481 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1423891000482 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1423891000483 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1423891000484 active site 1423891000485 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1423891000486 GSH binding site [chemical binding]; other site 1423891000487 catalytic residues [active] 1423891000488 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1423891000489 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 1423891000490 putative active site [active] 1423891000491 catalytic triad [active] 1423891000492 dimer interface [polypeptide binding]; other site 1423891000493 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5319 1423891000494 EamA-like transporter family; Region: EamA; pfam00892 1423891000495 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1423891000496 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1423891000497 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1423891000498 S-adenosylmethionine binding site [chemical binding]; other site 1423891000499 aspartate kinase; Reviewed; Region: PRK06635 1423891000500 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1423891000501 putative nucleotide binding site [chemical binding]; other site 1423891000502 putative catalytic residues [active] 1423891000503 putative Mg ion binding site [ion binding]; other site 1423891000504 putative aspartate binding site [chemical binding]; other site 1423891000505 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1423891000506 putative allosteric regulatory site; other site 1423891000507 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1423891000508 putative allosteric regulatory residue; other site 1423891000509 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 1423891000510 GAF domain; Region: GAF; pfam01590 1423891000511 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1423891000512 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1423891000513 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1423891000514 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1423891000515 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1423891000516 RF-1 domain; Region: RF-1; pfam00472 1423891000517 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 1423891000518 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1423891000519 S-adenosylmethionine binding site [chemical binding]; other site 1423891000520 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 1423891000521 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1423891000522 Clp amino terminal domain; Region: Clp_N; pfam02861 1423891000523 Clp amino terminal domain; Region: Clp_N; pfam02861 1423891000524 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1423891000525 Walker A motif; other site 1423891000526 ATP binding site [chemical binding]; other site 1423891000527 Walker B motif; other site 1423891000528 arginine finger; other site 1423891000529 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1423891000530 Walker A motif; other site 1423891000531 ATP binding site [chemical binding]; other site 1423891000532 Walker B motif; other site 1423891000533 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1423891000534 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1423891000535 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1423891000536 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1423891000537 Peptidase family M23; Region: Peptidase_M23; pfam01551 1423891000538 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1423891000539 Integrase core domain; Region: rve; pfam00665 1423891000540 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1423891000541 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1423891000542 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1423891000543 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1423891000544 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1423891000545 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1423891000546 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1423891000547 GTPase CgtA; Reviewed; Region: obgE; PRK12299 1423891000548 GTP1/OBG; Region: GTP1_OBG; pfam01018 1423891000549 Obg GTPase; Region: Obg; cd01898 1423891000550 G1 box; other site 1423891000551 GTP/Mg2+ binding site [chemical binding]; other site 1423891000552 Switch I region; other site 1423891000553 G2 box; other site 1423891000554 G3 box; other site 1423891000555 Switch II region; other site 1423891000556 G4 box; other site 1423891000557 G5 box; other site 1423891000558 gamma-glutamyl kinase; Provisional; Region: PRK05429 1423891000559 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1423891000560 nucleotide binding site [chemical binding]; other site 1423891000561 homotetrameric interface [polypeptide binding]; other site 1423891000562 putative phosphate binding site [ion binding]; other site 1423891000563 putative allosteric binding site; other site 1423891000564 PUA domain; Region: PUA; pfam01472 1423891000565 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1423891000566 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1423891000567 putative catalytic cysteine [active] 1423891000568 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1423891000569 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1423891000570 active site 1423891000571 (T/H)XGH motif; other site 1423891000572 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1423891000573 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1423891000574 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 1423891000575 Peptidase family M23; Region: Peptidase_M23; pfam01551 1423891000576 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1423891000577 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1423891000578 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1423891000579 protein binding site [polypeptide binding]; other site 1423891000580 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1423891000581 Catalytic dyad [active] 1423891000582 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1423891000583 putative active site [active] 1423891000584 Ap4A binding site [chemical binding]; other site 1423891000585 nudix motif; other site 1423891000586 putative metal binding site [ion binding]; other site 1423891000587 Predicted membrane protein [Function unknown]; Region: COG3619 1423891000588 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1423891000589 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1423891000590 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1423891000591 putative effector binding pocket; other site 1423891000592 dimerization interface [polypeptide binding]; other site 1423891000593 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1423891000594 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1423891000595 tetrameric interface [polypeptide binding]; other site 1423891000596 NAD binding site [chemical binding]; other site 1423891000597 catalytic residues [active] 1423891000598 pyridoxamine kinase; Validated; Region: PRK05756 1423891000599 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1423891000600 dimer interface [polypeptide binding]; other site 1423891000601 pyridoxal binding site [chemical binding]; other site 1423891000602 ATP binding site [chemical binding]; other site 1423891000603 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 1423891000604 active site clefts [active] 1423891000605 zinc binding site [ion binding]; other site 1423891000606 dimer interface [polypeptide binding]; other site 1423891000607 lytic murein transglycosylase; Region: MltB_2; TIGR02283 1423891000608 murein hydrolase B; Provisional; Region: PRK10760; cl17906 1423891000609 signal recognition particle protein; Provisional; Region: PRK10867 1423891000610 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1423891000611 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1423891000612 P loop; other site 1423891000613 GTP binding site [chemical binding]; other site 1423891000614 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1423891000615 chorismate mutase; Provisional; Region: PRK09239 1423891000616 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1423891000617 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1423891000618 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1423891000619 Repair protein; Region: Repair_PSII; pfam04536 1423891000620 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1423891000621 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1423891000622 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1423891000623 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1423891000624 purine monophosphate binding site [chemical binding]; other site 1423891000625 dimer interface [polypeptide binding]; other site 1423891000626 putative catalytic residues [active] 1423891000627 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1423891000628 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1423891000629 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5360 1423891000630 NusB family; Region: NusB; pfam01029 1423891000631 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 1423891000632 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1423891000633 S-adenosylmethionine binding site [chemical binding]; other site 1423891000634 heat shock protein HtpX; Provisional; Region: PRK01345 1423891000635 acetyl-CoA synthetase; Provisional; Region: PRK00174 1423891000636 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1423891000637 active site 1423891000638 CoA binding site [chemical binding]; other site 1423891000639 acyl-activating enzyme (AAE) consensus motif; other site 1423891000640 AMP binding site [chemical binding]; other site 1423891000641 acetate binding site [chemical binding]; other site 1423891000642 Usg protein, probable subunit of phosphoribosylanthranilate isomerase [Amino acid transport and metabolism]; Region: COG5425 1423891000643 Predicted membrane protein [Function unknown]; Region: COG1289 1423891000644 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1423891000645 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1423891000646 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1423891000647 catalytic residue [active] 1423891000648 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1423891000649 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1423891000650 HIGH motif; other site 1423891000651 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1423891000652 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1423891000653 active site 1423891000654 KMSKS motif; other site 1423891000655 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1423891000656 tRNA binding surface [nucleotide binding]; other site 1423891000657 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5468 1423891000658 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1423891000659 active site 1423891000660 intersubunit interactions; other site 1423891000661 catalytic residue [active] 1423891000662 primosome assembly protein PriA; Validated; Region: PRK05580 1423891000663 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1423891000664 putative Mg++ binding site [ion binding]; other site 1423891000665 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1423891000666 nucleotide binding region [chemical binding]; other site 1423891000667 ATP-binding site [chemical binding]; other site 1423891000668 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1423891000669 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1423891000670 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1423891000671 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1423891000672 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1423891000673 beta subunit interaction interface [polypeptide binding]; other site 1423891000674 Walker A motif; other site 1423891000675 ATP binding site [chemical binding]; other site 1423891000676 Walker B motif; other site 1423891000677 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1423891000678 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1423891000679 core domain interface [polypeptide binding]; other site 1423891000680 delta subunit interface [polypeptide binding]; other site 1423891000681 epsilon subunit interface [polypeptide binding]; other site 1423891000682 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1423891000683 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1423891000684 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1423891000685 alpha subunit interaction interface [polypeptide binding]; other site 1423891000686 Walker A motif; other site 1423891000687 ATP binding site [chemical binding]; other site 1423891000688 Walker B motif; other site 1423891000689 inhibitor binding site; inhibition site 1423891000690 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1423891000691 F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]; Region: AtpC; COG0355 1423891000692 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1423891000693 gamma subunit interface [polypeptide binding]; other site 1423891000694 epsilon subunit interface [polypeptide binding]; other site 1423891000695 LBP interface [polypeptide binding]; other site 1423891000696 MarR family; Region: MarR; pfam01047 1423891000697 transcriptional regulator SlyA; Provisional; Region: PRK03573 1423891000698 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1423891000699 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1423891000700 DNA-binding site [nucleotide binding]; DNA binding site 1423891000701 FCD domain; Region: FCD; pfam07729 1423891000702 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1423891000703 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 1423891000704 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1423891000705 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1423891000706 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1423891000707 TM-ABC transporter signature motif; other site 1423891000708 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1423891000709 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1423891000710 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1423891000711 TM-ABC transporter signature motif; other site 1423891000712 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1423891000713 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1423891000714 Walker A/P-loop; other site 1423891000715 ATP binding site [chemical binding]; other site 1423891000716 Q-loop/lid; other site 1423891000717 ABC transporter signature motif; other site 1423891000718 Walker B; other site 1423891000719 D-loop; other site 1423891000720 H-loop/switch region; other site 1423891000721 Uncharacterized conserved protein [Function unknown]; Region: COG3743 1423891000722 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1423891000723 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1423891000724 Walker A/P-loop; other site 1423891000725 ATP binding site [chemical binding]; other site 1423891000726 Q-loop/lid; other site 1423891000727 ABC transporter signature motif; other site 1423891000728 Walker B; other site 1423891000729 D-loop; other site 1423891000730 H-loop/switch region; other site 1423891000731 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1423891000732 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1423891000733 ligand binding site [chemical binding]; other site 1423891000734 dimerization interface [polypeptide binding]; other site 1423891000735 pyruvate carboxylase; Reviewed; Region: PRK12999 1423891000736 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1423891000737 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1423891000738 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1423891000739 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1423891000740 active site 1423891000741 catalytic residues [active] 1423891000742 metal binding site [ion binding]; metal-binding site 1423891000743 homodimer binding site [polypeptide binding]; other site 1423891000744 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1423891000745 carboxyltransferase (CT) interaction site; other site 1423891000746 biotinylation site [posttranslational modification]; other site 1423891000747 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1423891000748 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1423891000749 putative substrate translocation pore; other site 1423891000750 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 1423891000751 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1423891000752 NAD(P) binding site [chemical binding]; other site 1423891000753 active site 1423891000754 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1423891000755 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1423891000756 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1423891000757 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1423891000758 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1423891000759 substrate binding pocket [chemical binding]; other site 1423891000760 chain length determination region; other site 1423891000761 substrate-Mg2+ binding site; other site 1423891000762 catalytic residues [active] 1423891000763 aspartate-rich region 1; other site 1423891000764 active site lid residues [active] 1423891000765 aspartate-rich region 2; other site 1423891000766 Transglycosylase; Region: Transgly; pfam00912 1423891000767 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 1423891000768 putative acyltransferase; Provisional; Region: PRK05790 1423891000769 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1423891000770 dimer interface [polypeptide binding]; other site 1423891000771 active site 1423891000772 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1423891000773 ATP binding site [chemical binding]; other site 1423891000774 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1423891000775 putative Mg++ binding site [ion binding]; other site 1423891000776 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1423891000777 nucleotide binding region [chemical binding]; other site 1423891000778 ATP-binding site [chemical binding]; other site 1423891000779 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1423891000780 RNA binding surface [nucleotide binding]; other site 1423891000781 Ferredoxin [Energy production and conversion]; Region: COG1146 1423891000782 4Fe-4S binding domain; Region: Fer4; pfam00037 1423891000783 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 1423891000784 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1423891000785 RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500 1423891000786 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1423891000787 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1423891000788 DNA binding residues [nucleotide binding] 1423891000789 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1423891000790 MOSC domain; Region: MOSC; pfam03473 1423891000791 3-alpha domain; Region: 3-alpha; pfam03475 1423891000792 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 1423891000793 Peptidase family M48; Region: Peptidase_M48; pfam01435 1423891000794 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 1423891000795 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 1423891000796 Walker A/P-loop; other site 1423891000797 ATP binding site [chemical binding]; other site 1423891000798 Q-loop/lid; other site 1423891000799 ABC transporter signature motif; other site 1423891000800 Walker B; other site 1423891000801 D-loop; other site 1423891000802 H-loop/switch region; other site 1423891000803 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 1423891000804 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891000805 dimer interface [polypeptide binding]; other site 1423891000806 conserved gate region; other site 1423891000807 putative PBP binding loops; other site 1423891000808 ABC-ATPase subunit interface; other site 1423891000809 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891000810 dimer interface [polypeptide binding]; other site 1423891000811 conserved gate region; other site 1423891000812 putative PBP binding loops; other site 1423891000813 ABC-ATPase subunit interface; other site 1423891000814 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 1423891000815 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 1423891000816 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 1423891000817 Thiamine pyrophosphokinase; Region: TPK; cd07995 1423891000818 active site 1423891000819 dimerization interface [polypeptide binding]; other site 1423891000820 thiamine binding site [chemical binding]; other site 1423891000821 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1423891000822 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1423891000823 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1423891000824 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3750 1423891000825 Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931 1423891000826 Predicted integral membrane protein [Function unknown]; Region: COG5480 1423891000827 Pyruvate kinase, alpha/beta domain; Region: PK_C; pfam02887 1423891000828 TPR repeat; Region: TPR_11; pfam13414 1423891000829 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1423891000830 TPR motif; other site 1423891000831 binding surface 1423891000832 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1423891000833 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1423891000834 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1423891000835 NAD binding site [chemical binding]; other site 1423891000836 ATP-grasp domain; Region: ATP-grasp; pfam02222 1423891000837 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1423891000838 putative MFS family transporter protein; Provisional; Region: PRK03633 1423891000839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1423891000840 putative substrate translocation pore; other site 1423891000841 Uncharacterized small protein containing a coiled-coil domain [Function unknown]; Region: COG5509 1423891000842 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1423891000843 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1423891000844 NAD(P) binding site [chemical binding]; other site 1423891000845 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1423891000846 CoenzymeA binding site [chemical binding]; other site 1423891000847 subunit interaction site [polypeptide binding]; other site 1423891000848 PHB binding site; other site 1423891000849 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1423891000850 Predicted transcriptional regulator [Transcription]; Region: COG2378 1423891000851 HTH domain; Region: HTH_11; pfam08279 1423891000852 WYL domain; Region: WYL; pfam13280 1423891000853 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 1423891000854 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 1423891000855 acyl-activating enzyme (AAE) consensus motif; other site 1423891000856 putative AMP binding site [chemical binding]; other site 1423891000857 putative active site [active] 1423891000858 putative CoA binding site [chemical binding]; other site 1423891000859 Phosphoglycerate kinase; Region: PGK; pfam00162 1423891000860 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1423891000861 substrate binding site [chemical binding]; other site 1423891000862 hinge regions; other site 1423891000863 ADP binding site [chemical binding]; other site 1423891000864 catalytic site [active] 1423891000865 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1423891000866 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1423891000867 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1423891000868 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1423891000869 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1423891000870 TPP-binding site [chemical binding]; other site 1423891000871 dimer interface [polypeptide binding]; other site 1423891000872 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1423891000873 PYR/PP interface [polypeptide binding]; other site 1423891000874 dimer interface [polypeptide binding]; other site 1423891000875 TPP binding site [chemical binding]; other site 1423891000876 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1423891000877 Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division, chromosome partitioning]; Region: zapA; COG3027 1423891000878 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 1423891000879 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1423891000880 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1423891000881 putative active site [active] 1423891000882 metal binding site [ion binding]; metal-binding site 1423891000883 homodimer binding site [polypeptide binding]; other site 1423891000884 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1423891000885 Uncharacterized conserved protein [Function unknown]; Region: COG3543 1423891000886 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1423891000887 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1423891000888 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1423891000889 DNA-binding site [nucleotide binding]; DNA binding site 1423891000890 FCD domain; Region: FCD; pfam07729 1423891000891 hypothetical protein; Validated; Region: PRK00110 1423891000892 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 1423891000893 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 1423891000894 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1423891000895 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1423891000896 Walker A/P-loop; other site 1423891000897 ATP binding site [chemical binding]; other site 1423891000898 Q-loop/lid; other site 1423891000899 ABC transporter signature motif; other site 1423891000900 Walker B; other site 1423891000901 D-loop; other site 1423891000902 H-loop/switch region; other site 1423891000903 hypothetical protein; Validated; Region: PRK09039 1423891000904 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1423891000905 ligand binding site [chemical binding]; other site 1423891000906 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1423891000907 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1423891000908 active site 1423891000909 dimerization interface [polypeptide binding]; other site 1423891000910 elongation factor P; Validated; Region: PRK00529 1423891000911 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1423891000912 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1423891000913 RNA binding site [nucleotide binding]; other site 1423891000914 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1423891000915 RNA binding site [nucleotide binding]; other site 1423891000916 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1423891000917 Sel1-like repeats; Region: SEL1; smart00671 1423891000918 Sel1-like repeats; Region: SEL1; smart00671 1423891000919 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1423891000920 active site 1423891000921 thiamine phosphate binding site [chemical binding]; other site 1423891000922 pyrophosphate binding site [ion binding]; other site 1423891000923 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4645 1423891000924 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1423891000925 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1423891000926 active site 1423891000927 putative DNA-binding cleft [nucleotide binding]; other site 1423891000928 dimer interface [polypeptide binding]; other site 1423891000929 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1423891000930 RuvA N terminal domain; Region: RuvA_N; pfam01330 1423891000931 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1423891000932 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1423891000933 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1423891000934 Walker A motif; other site 1423891000935 ATP binding site [chemical binding]; other site 1423891000936 Walker B motif; other site 1423891000937 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1423891000938 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1423891000939 active site 1423891000940 TolQ protein; Region: tolQ; TIGR02796 1423891000941 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1423891000942 TolR protein; Region: tolR; TIGR02801 1423891000943 translocation protein TolB; Provisional; Region: tolB; PRK05137 1423891000944 TolB amino-terminal domain; Region: TolB_N; pfam04052 1423891000945 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1423891000946 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1423891000947 putative outer membrane lipoprotein; Provisional; Region: PRK09967 1423891000948 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1423891000949 ligand binding site [chemical binding]; other site 1423891000950 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1423891000951 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1423891000952 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1423891000953 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1423891000954 FtsH Extracellular; Region: FtsH_ext; pfam06480 1423891000955 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1423891000956 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1423891000957 Walker A motif; other site 1423891000958 ATP binding site [chemical binding]; other site 1423891000959 Walker B motif; other site 1423891000960 arginine finger; other site 1423891000961 Peptidase family M41; Region: Peptidase_M41; pfam01434 1423891000962 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 1423891000963 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1423891000964 active site 1423891000965 substrate binding site [chemical binding]; other site 1423891000966 metal binding site [ion binding]; metal-binding site 1423891000967 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1423891000968 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1423891000969 Sodium Bile acid symporter family; Region: SBF; pfam01758 1423891000970 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 1423891000971 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1423891000972 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1423891000973 catalytic residue [active] 1423891000974 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1423891000975 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1423891000976 ligand binding site [chemical binding]; other site 1423891000977 NAD binding site [chemical binding]; other site 1423891000978 dimerization interface [polypeptide binding]; other site 1423891000979 catalytic site [active] 1423891000980 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1423891000981 putative L-serine binding site [chemical binding]; other site 1423891000982 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1423891000983 Cytochrome P450; Region: p450; cl12078 1423891000984 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1423891000985 Coenzyme A binding pocket [chemical binding]; other site 1423891000986 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1423891000987 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1423891000988 GDP-binding site [chemical binding]; other site 1423891000989 ACT binding site; other site 1423891000990 IMP binding site; other site 1423891000991 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1423891000992 metabolite-proton symporter; Region: 2A0106; TIGR00883 1423891000993 putative substrate translocation pore; other site 1423891000994 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 1423891000995 diiron binding motif [ion binding]; other site 1423891000996 Uncharacterized conserved protein [Function unknown]; Region: COG1633 1423891000997 CCC1-related protein family; Region: CCC1_like_1; cd02437 1423891000998 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1423891000999 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1423891001000 putative active site [active] 1423891001001 putative dimer interface [polypeptide binding]; other site 1423891001002 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1423891001003 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1423891001004 dimerization interface [polypeptide binding]; other site 1423891001005 putative DNA binding site [nucleotide binding]; other site 1423891001006 putative Zn2+ binding site [ion binding]; other site 1423891001007 AsnC family; Region: AsnC_trans_reg; pfam01037 1423891001008 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1423891001009 trimer interface [polypeptide binding]; other site 1423891001010 active site 1423891001011 macrolide transporter subunit MacA; Provisional; Region: PRK11578 1423891001012 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1423891001013 HlyD family secretion protein; Region: HlyD_3; pfam13437 1423891001014 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 1423891001015 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1423891001016 Walker A/P-loop; other site 1423891001017 ATP binding site [chemical binding]; other site 1423891001018 Q-loop/lid; other site 1423891001019 ABC transporter signature motif; other site 1423891001020 Walker B; other site 1423891001021 D-loop; other site 1423891001022 H-loop/switch region; other site 1423891001023 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1423891001024 FtsX-like permease family; Region: FtsX; pfam02687 1423891001025 Predicted periplasmic protein [Function unknown]; Region: COG3698 1423891001026 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1423891001027 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1423891001028 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 1423891001029 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1423891001030 TonB system transport protein ExbD, group 1; Region: ExbD_1; TIGR02803 1423891001031 tonB-system energizer ExbB; Region: exbB; TIGR02797 1423891001032 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 1423891001033 CHASE3 domain; Region: CHASE3; pfam05227 1423891001034 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1423891001035 Histidine kinase; Region: HisKA_2; pfam07568 1423891001036 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1423891001037 ATP binding site [chemical binding]; other site 1423891001038 Mg2+ binding site [ion binding]; other site 1423891001039 G-X-G motif; other site 1423891001040 RNA polymerase sigma factor; Provisional; Region: PRK12516 1423891001041 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1423891001042 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1423891001043 DNA binding residues [nucleotide binding] 1423891001044 two-component response regulator; Provisional; Region: PRK09191 1423891001045 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1423891001046 active site 1423891001047 phosphorylation site [posttranslational modification] 1423891001048 intermolecular recognition site; other site 1423891001049 dimerization interface [polypeptide binding]; other site 1423891001050 PAS fold; Region: PAS_4; pfam08448 1423891001051 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1423891001052 HWE histidine kinase; Region: HWE_HK; pfam07536 1423891001053 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1423891001054 metal binding site 2 [ion binding]; metal-binding site 1423891001055 putative DNA binding helix; other site 1423891001056 metal binding site 1 [ion binding]; metal-binding site 1423891001057 dimer interface [polypeptide binding]; other site 1423891001058 structural Zn2+ binding site [ion binding]; other site 1423891001059 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1423891001060 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1423891001061 RNA binding surface [nucleotide binding]; other site 1423891001062 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1423891001063 active site 1423891001064 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1423891001065 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1423891001066 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1423891001067 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1423891001068 DNA binding residues [nucleotide binding] 1423891001069 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1423891001070 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1423891001071 Coenzyme A binding pocket [chemical binding]; other site 1423891001072 Malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate cycle, which allows certain organisms, like plants and fungi, to derive their...; Region: malate_synt; cl17217 1423891001073 malate synthase G; Provisional; Region: PRK02999 1423891001074 active site 1423891001075 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1423891001076 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 1423891001077 active site 1423891001078 HIGH motif; other site 1423891001079 nucleotide binding site [chemical binding]; other site 1423891001080 active site 1423891001081 KMSKS motif; other site 1423891001082 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1423891001083 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1423891001084 helix-hairpin-helix signature motif; other site 1423891001085 substrate binding pocket [chemical binding]; other site 1423891001086 active site 1423891001087 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1423891001088 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1423891001089 active site 1423891001090 Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495 1423891001091 Predicted membrane protein [Function unknown]; Region: COG1238 1423891001092 succinic semialdehyde dehydrogenase; Region: PLN02278 1423891001093 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1423891001094 tetramerization interface [polypeptide binding]; other site 1423891001095 NAD(P) binding site [chemical binding]; other site 1423891001096 catalytic residues [active] 1423891001097 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1423891001098 choline dehydrogenase; Validated; Region: PRK02106 1423891001099 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1423891001100 Uncharacterized conserved protein [Function unknown]; Region: COG5591 1423891001101 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1423891001102 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1423891001103 Walker A/P-loop; other site 1423891001104 ATP binding site [chemical binding]; other site 1423891001105 Q-loop/lid; other site 1423891001106 ABC transporter signature motif; other site 1423891001107 Walker B; other site 1423891001108 D-loop; other site 1423891001109 H-loop/switch region; other site 1423891001110 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1423891001111 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1423891001112 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1423891001113 TM-ABC transporter signature motif; other site 1423891001114 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 1423891001115 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1423891001116 putative ligand binding site [chemical binding]; other site 1423891001117 short chain dehydrogenase; Provisional; Region: PRK06841 1423891001118 classical (c) SDRs; Region: SDR_c; cd05233 1423891001119 NAD(P) binding site [chemical binding]; other site 1423891001120 active site 1423891001121 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1423891001122 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 1423891001123 DAK2 domain; Region: Dak2; pfam02734 1423891001124 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1423891001125 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1423891001126 DNA binding residues [nucleotide binding] 1423891001127 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1423891001128 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 1423891001129 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1423891001130 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1423891001131 DAK2 domain; Region: Dak2; cl03685 1423891001132 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1423891001133 active site 1423891001134 nucleophile elbow; other site 1423891001135 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1423891001136 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 1423891001137 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 1423891001138 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 1423891001139 NAD binding site [chemical binding]; other site 1423891001140 substrate binding site [chemical binding]; other site 1423891001141 homotetramer interface [polypeptide binding]; other site 1423891001142 homodimer interface [polypeptide binding]; other site 1423891001143 active site 1423891001144 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 1423891001145 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 1423891001146 NAD binding site [chemical binding]; other site 1423891001147 substrate binding site [chemical binding]; other site 1423891001148 homotetramer interface [polypeptide binding]; other site 1423891001149 homodimer interface [polypeptide binding]; other site 1423891001150 active site 1423891001151 isocitrate lyase; Provisional; Region: PRK15063 1423891001152 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1423891001153 tetramer interface [polypeptide binding]; other site 1423891001154 active site 1423891001155 Mg2+/Mn2+ binding site [ion binding]; other site 1423891001156 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1423891001157 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1423891001158 non-specific DNA binding site [nucleotide binding]; other site 1423891001159 salt bridge; other site 1423891001160 sequence-specific DNA binding site [nucleotide binding]; other site 1423891001161 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1423891001162 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1423891001163 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1423891001164 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1423891001165 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1423891001166 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1423891001167 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1423891001168 Walker A/P-loop; other site 1423891001169 ATP binding site [chemical binding]; other site 1423891001170 Q-loop/lid; other site 1423891001171 ABC transporter signature motif; other site 1423891001172 Walker B; other site 1423891001173 D-loop; other site 1423891001174 H-loop/switch region; other site 1423891001175 TOBE domain; Region: TOBE_2; pfam08402 1423891001176 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891001177 dimer interface [polypeptide binding]; other site 1423891001178 conserved gate region; other site 1423891001179 putative PBP binding loops; other site 1423891001180 ABC-ATPase subunit interface; other site 1423891001181 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1423891001182 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891001183 dimer interface [polypeptide binding]; other site 1423891001184 conserved gate region; other site 1423891001185 putative PBP binding loops; other site 1423891001186 ABC-ATPase subunit interface; other site 1423891001187 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 1423891001188 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1423891001189 PAS domain; Region: PAS_8; pfam13188 1423891001190 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1423891001191 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1423891001192 putative active site [active] 1423891001193 heme pocket [chemical binding]; other site 1423891001194 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1423891001195 dimer interface [polypeptide binding]; other site 1423891001196 phosphorylation site [posttranslational modification] 1423891001197 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1423891001198 ATP binding site [chemical binding]; other site 1423891001199 Mg2+ binding site [ion binding]; other site 1423891001200 G-X-G motif; other site 1423891001201 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 1423891001202 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1423891001203 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1423891001204 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1423891001205 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1423891001206 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1423891001207 inhibitor-cofactor binding pocket; inhibition site 1423891001208 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1423891001209 catalytic residue [active] 1423891001210 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1423891001211 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1423891001212 active site 1423891001213 phosphorylation site [posttranslational modification] 1423891001214 intermolecular recognition site; other site 1423891001215 dimerization interface [polypeptide binding]; other site 1423891001216 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1423891001217 DNA binding site [nucleotide binding] 1423891001218 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1423891001219 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1423891001220 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1423891001221 Ligand Binding Site [chemical binding]; other site 1423891001222 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1423891001223 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1423891001224 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1423891001225 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1423891001226 putative Zn2+ binding site [ion binding]; other site 1423891001227 putative DNA binding site [nucleotide binding]; other site 1423891001228 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1423891001229 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891001230 dimer interface [polypeptide binding]; other site 1423891001231 conserved gate region; other site 1423891001232 putative PBP binding loops; other site 1423891001233 ABC-ATPase subunit interface; other site 1423891001234 dipeptide transporter; Provisional; Region: PRK10913 1423891001235 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1423891001236 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891001237 dimer interface [polypeptide binding]; other site 1423891001238 conserved gate region; other site 1423891001239 putative PBP binding loops; other site 1423891001240 ABC-ATPase subunit interface; other site 1423891001241 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1423891001242 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1423891001243 Walker A/P-loop; other site 1423891001244 ATP binding site [chemical binding]; other site 1423891001245 Q-loop/lid; other site 1423891001246 ABC transporter signature motif; other site 1423891001247 Walker B; other site 1423891001248 D-loop; other site 1423891001249 H-loop/switch region; other site 1423891001250 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1423891001251 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 1423891001252 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1423891001253 Walker A/P-loop; other site 1423891001254 ATP binding site [chemical binding]; other site 1423891001255 Q-loop/lid; other site 1423891001256 ABC transporter signature motif; other site 1423891001257 Walker B; other site 1423891001258 D-loop; other site 1423891001259 H-loop/switch region; other site 1423891001260 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891001261 dimer interface [polypeptide binding]; other site 1423891001262 conserved gate region; other site 1423891001263 putative PBP binding loops; other site 1423891001264 ABC-ATPase subunit interface; other site 1423891001265 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1423891001266 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 1423891001267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1423891001268 putative substrate translocation pore; other site 1423891001269 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1423891001270 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1423891001271 MarR family; Region: MarR_2; pfam12802 1423891001272 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1423891001273 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1423891001274 putative DNA binding site [nucleotide binding]; other site 1423891001275 putative Zn2+ binding site [ion binding]; other site 1423891001276 AsnC family; Region: AsnC_trans_reg; pfam01037 1423891001277 anthranilate synthase; Provisional; Region: PRK13566 1423891001278 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1423891001279 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1423891001280 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1423891001281 glutamine binding [chemical binding]; other site 1423891001282 catalytic triad [active] 1423891001283 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1423891001284 Cation efflux family; Region: Cation_efflux; pfam01545 1423891001285 2-isopropylmalate synthase; Validated; Region: PRK03739 1423891001286 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1423891001287 active site 1423891001288 catalytic residues [active] 1423891001289 metal binding site [ion binding]; metal-binding site 1423891001290 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1423891001291 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1423891001292 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1423891001293 active site 1423891001294 metal binding site [ion binding]; metal-binding site 1423891001295 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 1423891001296 nudix motif; other site 1423891001297 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 1423891001298 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1423891001299 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1423891001300 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1423891001301 putative dimer interface [polypeptide binding]; other site 1423891001302 N-terminal domain interface [polypeptide binding]; other site 1423891001303 putative substrate binding pocket (H-site) [chemical binding]; other site 1423891001304 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1423891001305 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1423891001306 Coenzyme A binding pocket [chemical binding]; other site 1423891001307 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 1423891001308 N-terminal double-transmembrane domain; Region: two_anch; TIGR02226 1423891001309 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1423891001310 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 1423891001311 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1423891001312 Protein of unknown function DUF58; Region: DUF58; pfam01882 1423891001313 MoxR-like ATPases [General function prediction only]; Region: COG0714 1423891001314 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1423891001315 ATP binding site [chemical binding]; other site 1423891001316 Walker B motif; other site 1423891001317 arginine finger; other site 1423891001318 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1423891001319 putative active site [active] 1423891001320 putative CoA binding site [chemical binding]; other site 1423891001321 nudix motif; other site 1423891001322 metal binding site [ion binding]; metal-binding site 1423891001323 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 1423891001324 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1423891001325 active site 1423891001326 NTP binding site [chemical binding]; other site 1423891001327 metal binding triad [ion binding]; metal-binding site 1423891001328 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1423891001329 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 1423891001330 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1423891001331 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752 1423891001332 Purine nucleoside permease [Nucleotide transport and metabolism]; Region: NUP; COG5042 1423891001333 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1423891001334 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1423891001335 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1423891001336 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1423891001337 Walker A/P-loop; other site 1423891001338 ATP binding site [chemical binding]; other site 1423891001339 Q-loop/lid; other site 1423891001340 ABC transporter signature motif; other site 1423891001341 Walker B; other site 1423891001342 D-loop; other site 1423891001343 H-loop/switch region; other site 1423891001344 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1423891001345 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1423891001346 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1423891001347 Walker A/P-loop; other site 1423891001348 ATP binding site [chemical binding]; other site 1423891001349 Q-loop/lid; other site 1423891001350 ABC transporter signature motif; other site 1423891001351 Walker B; other site 1423891001352 D-loop; other site 1423891001353 H-loop/switch region; other site 1423891001354 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 1423891001355 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 1423891001356 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 1423891001357 [2Fe-2S] cluster binding site [ion binding]; other site 1423891001358 cytochrome b; Provisional; Region: CYTB; MTH00191 1423891001359 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1423891001360 Qi binding site; other site 1423891001361 intrachain domain interface; other site 1423891001362 interchain domain interface [polypeptide binding]; other site 1423891001363 heme bH binding site [chemical binding]; other site 1423891001364 heme bL binding site [chemical binding]; other site 1423891001365 Qo binding site; other site 1423891001366 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 1423891001367 interchain domain interface [polypeptide binding]; other site 1423891001368 intrachain domain interface; other site 1423891001369 Qi binding site; other site 1423891001370 Qo binding site; other site 1423891001371 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 1423891001372 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1423891001373 active site 1423891001374 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1423891001375 putative active site [active] 1423891001376 putative catalytic site [active] 1423891001377 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1423891001378 putative active site [active] 1423891001379 putative catalytic site [active] 1423891001380 GTP-binding protein YchF; Reviewed; Region: PRK09601 1423891001381 YchF GTPase; Region: YchF; cd01900 1423891001382 G1 box; other site 1423891001383 GTP/Mg2+ binding site [chemical binding]; other site 1423891001384 Switch I region; other site 1423891001385 G2 box; other site 1423891001386 Switch II region; other site 1423891001387 G3 box; other site 1423891001388 G4 box; other site 1423891001389 G5 box; other site 1423891001390 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1423891001391 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1423891001392 putative active site [active] 1423891001393 catalytic residue [active] 1423891001394 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1423891001395 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1423891001396 5S rRNA interface [nucleotide binding]; other site 1423891001397 CTC domain interface [polypeptide binding]; other site 1423891001398 L16 interface [polypeptide binding]; other site 1423891001399 HerA helicase [Replication, recombination, and repair]; Region: COG0433 1423891001400 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1423891001401 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1423891001402 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1423891001403 active site 1423891001404 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1423891001405 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1423891001406 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1423891001407 active site 1423891001408 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1423891001409 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1423891001410 Uncharacterized conserved protein [Function unknown]; Region: COG1565 1423891001411 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1423891001412 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 1423891001413 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1423891001414 dimer interface [polypeptide binding]; other site 1423891001415 putative tRNA-binding site [nucleotide binding]; other site 1423891001416 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1423891001417 dimer interface [polypeptide binding]; other site 1423891001418 phosphorylation site [posttranslational modification] 1423891001419 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1423891001420 ATP binding site [chemical binding]; other site 1423891001421 Mg2+ binding site [ion binding]; other site 1423891001422 G-X-G motif; other site 1423891001423 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1423891001424 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1423891001425 active site 1423891001426 phosphorylation site [posttranslational modification] 1423891001427 intermolecular recognition site; other site 1423891001428 dimerization interface [polypeptide binding]; other site 1423891001429 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1423891001430 DNA binding site [nucleotide binding] 1423891001431 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1423891001432 MarR family; Region: MarR_2; pfam12802 1423891001433 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1423891001434 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1423891001435 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1423891001436 catalytic residue [active] 1423891001437 excinuclease ABC subunit B; Provisional; Region: PRK05298 1423891001438 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1423891001439 ATP binding site [chemical binding]; other site 1423891001440 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1423891001441 nucleotide binding region [chemical binding]; other site 1423891001442 ATP-binding site [chemical binding]; other site 1423891001443 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1423891001444 UvrB/uvrC motif; Region: UVR; pfam02151 1423891001445 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 1423891001446 Bacterial SH3 domain; Region: SH3_3; pfam08239 1423891001447 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1423891001448 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921 1423891001449 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 1423891001450 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1423891001451 EamA-like transporter family; Region: EamA; pfam00892 1423891001452 EamA-like transporter family; Region: EamA; pfam00892 1423891001453 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1423891001454 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1423891001455 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1423891001456 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1423891001457 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1423891001458 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1423891001459 AsnC family; Region: AsnC_trans_reg; pfam01037 1423891001460 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1423891001461 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1423891001462 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1423891001463 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1423891001464 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1423891001465 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1423891001466 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1423891001467 putative effector binding pocket; other site 1423891001468 dimerization interface [polypeptide binding]; other site 1423891001469 aspartate aminotransferase; Provisional; Region: PRK05764 1423891001470 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1423891001471 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1423891001472 homodimer interface [polypeptide binding]; other site 1423891001473 catalytic residue [active] 1423891001474 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1423891001475 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 1423891001476 putative C-terminal domain interface [polypeptide binding]; other site 1423891001477 putative GSH binding site (G-site) [chemical binding]; other site 1423891001478 putative dimer interface [polypeptide binding]; other site 1423891001479 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1423891001480 N-terminal domain interface [polypeptide binding]; other site 1423891001481 dimer interface [polypeptide binding]; other site 1423891001482 substrate binding pocket (H-site) [chemical binding]; other site 1423891001483 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1423891001484 DNA-binding site [nucleotide binding]; DNA binding site 1423891001485 RNA-binding motif; other site 1423891001486 NUDIX domain; Region: NUDIX; pfam00293 1423891001487 nudix motif; other site 1423891001488 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1423891001489 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1423891001490 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1423891001491 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1423891001492 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1423891001493 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1423891001494 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1423891001495 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1423891001496 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1423891001497 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1423891001498 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1423891001499 IMP binding site; other site 1423891001500 dimer interface [polypeptide binding]; other site 1423891001501 partial ornithine binding site; other site 1423891001502 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1423891001503 LytTr DNA-binding domain; Region: LytTR; pfam04397 1423891001504 Predicted membrane protein [Function unknown]; Region: COG5395 1423891001505 Predicted metalloprotease [General function prediction only]; Region: COG2321 1423891001506 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1423891001507 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1423891001508 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1423891001509 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1423891001510 catalytic site [active] 1423891001511 subunit interface [polypeptide binding]; other site 1423891001512 Uncharacterized conserved protein [Function unknown]; Region: COG1610 1423891001513 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1423891001514 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1423891001515 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1423891001516 PhoU domain; Region: PhoU; pfam01895 1423891001517 PhoU domain; Region: PhoU; pfam01895 1423891001518 DNA primase; Validated; Region: dnaG; PRK05667 1423891001519 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1423891001520 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1423891001521 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1423891001522 active site 1423891001523 metal binding site [ion binding]; metal-binding site 1423891001524 interdomain interaction site; other site 1423891001525 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1423891001526 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1423891001527 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1423891001528 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1423891001529 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1423891001530 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1423891001531 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1423891001532 DNA binding residues [nucleotide binding] 1423891001533 hypothetical protein; Provisional; Region: PRK05170 1423891001534 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1423891001535 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1423891001536 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1423891001537 active site 1423891001538 catalytic residues [active] 1423891001539 DNA binding site [nucleotide binding] 1423891001540 Int/Topo IB signature motif; other site 1423891001541 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 1423891001542 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1423891001543 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1423891001544 active site 1423891001545 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899 1423891001546 Isochorismatase family; Region: Isochorismatase; pfam00857 1423891001547 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1423891001548 catalytic triad [active] 1423891001549 metal binding site [ion binding]; metal-binding site 1423891001550 conserved cis-peptide bond; other site 1423891001551 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1423891001552 PhnA protein; Region: PhnA; pfam03831 1423891001553 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1423891001554 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 1423891001555 FAD binding pocket [chemical binding]; other site 1423891001556 FAD binding motif [chemical binding]; other site 1423891001557 phosphate binding motif [ion binding]; other site 1423891001558 beta-alpha-beta structure motif; other site 1423891001559 NAD binding pocket [chemical binding]; other site 1423891001560 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1423891001561 catalytic loop [active] 1423891001562 iron binding site [ion binding]; other site 1423891001563 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1423891001564 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1423891001565 [2Fe-2S] cluster binding site [ion binding]; other site 1423891001566 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 1423891001567 putative alpha subunit interface [polypeptide binding]; other site 1423891001568 putative active site [active] 1423891001569 putative substrate binding site [chemical binding]; other site 1423891001570 Fe binding site [ion binding]; other site 1423891001571 Protein of unknown function (DUF1498); Region: DUF1498; pfam07385 1423891001572 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1423891001573 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1423891001574 PGAP1-like protein; Region: PGAP1; pfam07819 1423891001575 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1423891001576 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1423891001577 Walker A/P-loop; other site 1423891001578 ATP binding site [chemical binding]; other site 1423891001579 Q-loop/lid; other site 1423891001580 ABC transporter signature motif; other site 1423891001581 Walker B; other site 1423891001582 D-loop; other site 1423891001583 H-loop/switch region; other site 1423891001584 ABC transporter; Region: ABC_tran_2; pfam12848 1423891001585 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1423891001586 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1423891001587 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1423891001588 S-adenosylmethionine binding site [chemical binding]; other site 1423891001589 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1423891001590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1423891001591 putative substrate translocation pore; other site 1423891001592 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1423891001593 dimerization interface [polypeptide binding]; other site 1423891001594 putative DNA binding site [nucleotide binding]; other site 1423891001595 putative Zn2+ binding site [ion binding]; other site 1423891001596 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1423891001597 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1423891001598 S-adenosylmethionine binding site [chemical binding]; other site 1423891001599 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1423891001600 FAD binding site [chemical binding]; other site 1423891001601 Predicted permeases [General function prediction only]; Region: COG0679 1423891001602 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1423891001603 murein hydrolase B; Provisional; Region: PRK10760; cl17906 1423891001604 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1423891001605 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 1423891001606 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 1423891001607 active site 1423891001608 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 1423891001609 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 1423891001610 putative metal binding site [ion binding]; other site 1423891001611 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1423891001612 HSP70 interaction site [polypeptide binding]; other site 1423891001613 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1423891001614 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1423891001615 amidase catalytic site [active] 1423891001616 Zn binding residues [ion binding]; other site 1423891001617 substrate binding site [chemical binding]; other site 1423891001618 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1423891001619 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1423891001620 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1423891001621 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1423891001622 catalytic residue [active] 1423891001623 manganese transport protein MntH; Reviewed; Region: PRK00701 1423891001624 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1423891001625 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1423891001626 MraW methylase family; Region: Methyltransf_5; cl17771 1423891001627 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 1423891001628 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1423891001629 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1423891001630 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1423891001631 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1423891001632 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1423891001633 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1423891001634 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1423891001635 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093 1423891001636 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1423891001637 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1423891001638 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1423891001639 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1423891001640 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1423891001641 Mg++ binding site [ion binding]; other site 1423891001642 putative catalytic motif [active] 1423891001643 putative substrate binding site [chemical binding]; other site 1423891001644 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 1423891001645 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1423891001646 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1423891001647 cell division protein FtsW; Region: ftsW; TIGR02614 1423891001648 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1423891001649 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1423891001650 active site 1423891001651 homodimer interface [polypeptide binding]; other site 1423891001652 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1423891001653 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1423891001654 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1423891001655 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1423891001656 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1423891001657 FAD binding domain; Region: FAD_binding_4; pfam01565 1423891001658 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1423891001659 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1423891001660 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1423891001661 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1423891001662 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1423891001663 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1423891001664 Cell division protein FtsQ; Region: FtsQ; pfam03799 1423891001665 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1423891001666 Cell division protein FtsA; Region: FtsA; smart00842 1423891001667 Cell division protein FtsA; Region: FtsA; pfam14450 1423891001668 cell division protein FtsZ; Validated; Region: PRK09330 1423891001669 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1423891001670 nucleotide binding site [chemical binding]; other site 1423891001671 SulA interaction site; other site 1423891001672 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 1423891001673 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1423891001674 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1423891001675 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 1423891001676 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1423891001677 binding surface 1423891001678 TPR motif; other site 1423891001679 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1423891001680 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1423891001681 Walker A/P-loop; other site 1423891001682 ATP binding site [chemical binding]; other site 1423891001683 Q-loop/lid; other site 1423891001684 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1423891001685 ABC transporter signature motif; other site 1423891001686 Walker B; other site 1423891001687 D-loop; other site 1423891001688 H-loop/switch region; other site 1423891001689 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1423891001690 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1423891001691 nucleotide binding pocket [chemical binding]; other site 1423891001692 K-X-D-G motif; other site 1423891001693 catalytic site [active] 1423891001694 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1423891001695 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1423891001696 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1423891001697 Dimer interface [polypeptide binding]; other site 1423891001698 BRCT sequence motif; other site 1423891001699 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1423891001700 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1423891001701 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 1423891001702 active site 1423891001703 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 1423891001704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1423891001705 S-adenosylmethionine binding site [chemical binding]; other site 1423891001706 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1423891001707 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1423891001708 Cu(I) binding site [ion binding]; other site 1423891001709 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 1423891001710 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1423891001711 trimer interface [polypeptide binding]; other site 1423891001712 active site 1423891001713 substrate binding site [chemical binding]; other site 1423891001714 CoA binding site [chemical binding]; other site 1423891001715 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 1423891001716 CreA protein; Region: CreA; pfam05981 1423891001717 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1423891001718 Part of AAA domain; Region: AAA_19; pfam13245 1423891001719 Family description; Region: UvrD_C_2; pfam13538 1423891001720 serine/threonine protein kinase; Provisional; Region: PRK09188 1423891001721 serine/threonine protein kinase; Provisional; Region: PRK12274 1423891001722 Uncharacterized conserved protein [Function unknown]; Region: COG4702 1423891001723 FAD binding domain; Region: FAD_binding_4; pfam01565 1423891001724 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 1423891001725 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1423891001726 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814 1423891001727 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1423891001728 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1423891001729 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 1423891001730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1423891001731 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1423891001732 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1423891001733 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1423891001734 dimerization interface [polypeptide binding]; other site 1423891001735 active site 1423891001736 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1423891001737 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1423891001738 folate binding site [chemical binding]; other site 1423891001739 NADP+ binding site [chemical binding]; other site 1423891001740 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 1423891001741 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1423891001742 HflK protein; Region: hflK; TIGR01933 1423891001743 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1423891001744 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1423891001745 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1423891001746 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1423891001747 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1423891001748 protein binding site [polypeptide binding]; other site 1423891001749 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1423891001750 protein binding site [polypeptide binding]; other site 1423891001751 Predicted flavoproteins [General function prediction only]; Region: COG2081 1423891001752 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1423891001753 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1423891001754 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1423891001755 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1423891001756 motif II; other site 1423891001757 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1423891001758 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1423891001759 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 1423891001760 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1423891001761 PYR/PP interface [polypeptide binding]; other site 1423891001762 dimer interface [polypeptide binding]; other site 1423891001763 TPP binding site [chemical binding]; other site 1423891001764 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1423891001765 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1423891001766 TPP-binding site [chemical binding]; other site 1423891001767 dimer interface [polypeptide binding]; other site 1423891001768 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1423891001769 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1423891001770 putative valine binding site [chemical binding]; other site 1423891001771 dimer interface [polypeptide binding]; other site 1423891001772 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1423891001773 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 1423891001774 AAA domain; Region: AAA_30; pfam13604 1423891001775 Family description; Region: UvrD_C_2; pfam13538 1423891001776 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1423891001777 active site 1423891001778 hydrophilic channel; other site 1423891001779 dimerization interface [polypeptide binding]; other site 1423891001780 catalytic residues [active] 1423891001781 active site lid [active] 1423891001782 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 1423891001783 potassium uptake protein; Region: kup; TIGR00794 1423891001784 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1423891001785 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1423891001786 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1423891001787 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1423891001788 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1423891001789 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1423891001790 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1423891001791 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1423891001792 homodimer interface [polypeptide binding]; other site 1423891001793 catalytic residue [active] 1423891001794 BA14K-like protein; Region: BA14K; pfam07886 1423891001795 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1423891001796 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 1423891001797 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1423891001798 camphor resistance protein CrcB; Provisional; Region: ccrB; PRK01636 1423891001799 Uncharacterized conserved protein [Function unknown]; Region: COG3439 1423891001800 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1423891001801 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1423891001802 Walker A/P-loop; other site 1423891001803 ATP binding site [chemical binding]; other site 1423891001804 Q-loop/lid; other site 1423891001805 ABC transporter signature motif; other site 1423891001806 Walker B; other site 1423891001807 D-loop; other site 1423891001808 H-loop/switch region; other site 1423891001809 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 1423891001810 cobalt transport protein CbiM; Validated; Region: PRK06265 1423891001811 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 1423891001812 ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266 1423891001813 Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413 1423891001814 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 1423891001815 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1423891001816 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1423891001817 UreF; Region: UreF; pfam01730 1423891001818 urease accessory protein UreE; Provisional; Region: ureE; PRK14711 1423891001819 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1423891001820 dimer interface [polypeptide binding]; other site 1423891001821 catalytic residues [active] 1423891001822 urease subunit alpha; Reviewed; Region: ureC; PRK13309 1423891001823 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1423891001824 subunit interactions [polypeptide binding]; other site 1423891001825 active site 1423891001826 flap region; other site 1423891001827 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1423891001828 alpha-beta subunit interface [polypeptide binding]; other site 1423891001829 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1423891001830 alpha-gamma subunit interface [polypeptide binding]; other site 1423891001831 beta-gamma subunit interface [polypeptide binding]; other site 1423891001832 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1423891001833 HlyD family secretion protein; Region: HlyD_3; pfam13437 1423891001834 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1423891001835 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1423891001836 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1423891001837 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1423891001838 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1423891001839 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 1423891001840 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1423891001841 N-terminal plug; other site 1423891001842 ligand-binding site [chemical binding]; other site 1423891001843 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1423891001844 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1423891001845 intersubunit interface [polypeptide binding]; other site 1423891001846 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1423891001847 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1423891001848 ABC-ATPase subunit interface; other site 1423891001849 dimer interface [polypeptide binding]; other site 1423891001850 putative PBP binding regions; other site 1423891001851 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1423891001852 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1423891001853 Walker A/P-loop; other site 1423891001854 ATP binding site [chemical binding]; other site 1423891001855 Q-loop/lid; other site 1423891001856 ABC transporter signature motif; other site 1423891001857 Walker B; other site 1423891001858 D-loop; other site 1423891001859 H-loop/switch region; other site 1423891001860 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1423891001861 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1423891001862 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1423891001863 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 1423891001864 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1423891001865 putative ligand binding site [chemical binding]; other site 1423891001866 short chain dehydrogenase; Provisional; Region: PRK06198 1423891001867 classical (c) SDRs; Region: SDR_c; cd05233 1423891001868 NAD(P) binding site [chemical binding]; other site 1423891001869 active site 1423891001870 Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154 1423891001871 EF-hand domain pair; Region: EF_hand_5; pfam13499 1423891001872 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 1423891001873 Ca2+ binding site [ion binding]; other site 1423891001874 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 1423891001875 Ca2+ binding site [ion binding]; other site 1423891001876 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1423891001877 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1423891001878 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1423891001879 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1423891001880 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1423891001881 Transporter associated domain; Region: CorC_HlyC; smart01091 1423891001882 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CysP; COG4150 1423891001883 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1423891001884 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1423891001885 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891001886 dimer interface [polypeptide binding]; other site 1423891001887 conserved gate region; other site 1423891001888 putative PBP binding loops; other site 1423891001889 ABC-ATPase subunit interface; other site 1423891001890 sulfate transport protein; Provisional; Region: cysT; CHL00187 1423891001891 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891001892 dimer interface [polypeptide binding]; other site 1423891001893 conserved gate region; other site 1423891001894 putative PBP binding loops; other site 1423891001895 ABC-ATPase subunit interface; other site 1423891001896 Serine hydrolase; Region: Ser_hydrolase; pfam06821 1423891001897 Predicted integral membrane protein [Function unknown]; Region: COG0392 1423891001898 putative cation:proton antiport protein; Provisional; Region: PRK10669 1423891001899 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 1423891001900 TrkA-N domain; Region: TrkA_N; pfam02254 1423891001901 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1423891001902 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 1423891001903 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1423891001904 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1423891001905 Protein export membrane protein; Region: SecD_SecF; pfam02355 1423891001906 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 1423891001907 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1423891001908 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1423891001909 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 1423891001910 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1423891001911 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1423891001912 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1423891001913 conserved cys residue [active] 1423891001914 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1423891001915 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1423891001916 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1423891001917 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1423891001918 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1423891001919 dimerization interface [polypeptide binding]; other site 1423891001920 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1423891001921 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1423891001922 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1423891001923 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 1423891001924 substrate binding pocket [chemical binding]; other site 1423891001925 FAD binding site [chemical binding]; other site 1423891001926 catalytic base [active] 1423891001927 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 1423891001928 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1423891001929 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1423891001930 cobyric acid synthase; Provisional; Region: PRK00784 1423891001931 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1423891001932 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1423891001933 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1423891001934 catalytic triad [active] 1423891001935 cobalt transporter subunit CbtB (proposed); Region: CbtB; TIGR02459 1423891001936 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1423891001937 homotrimer interface [polypeptide binding]; other site 1423891001938 Walker A motif; other site 1423891001939 GTP binding site [chemical binding]; other site 1423891001940 Walker B motif; other site 1423891001941 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 1423891001942 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1423891001943 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1423891001944 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1423891001945 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1423891001946 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1423891001947 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1423891001948 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1423891001949 homodimer interface [polypeptide binding]; other site 1423891001950 Walker A motif; other site 1423891001951 ATP binding site [chemical binding]; other site 1423891001952 hydroxycobalamin binding site [chemical binding]; other site 1423891001953 Walker B motif; other site 1423891001954 Predicted membrane protein [Function unknown]; Region: COG2510 1423891001955 hypothetical protein; Provisional; Region: PRK10621 1423891001956 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1423891001957 tellurium resistance terB-like protein; Region: terB_like; cd07177 1423891001958 metal binding site [ion binding]; metal-binding site 1423891001959 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1423891001960 active site 1423891001961 SAM binding site [chemical binding]; other site 1423891001962 homodimer interface [polypeptide binding]; other site 1423891001963 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 1423891001964 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 1423891001965 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1423891001966 active site 1423891001967 SAM binding site [chemical binding]; other site 1423891001968 homodimer interface [polypeptide binding]; other site 1423891001969 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1423891001970 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1423891001971 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1423891001972 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 1423891001973 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1423891001974 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1423891001975 homodimer interface [polypeptide binding]; other site 1423891001976 catalytic residue [active] 1423891001977 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1423891001978 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1423891001979 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1423891001980 ligand binding site [chemical binding]; other site 1423891001981 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1423891001982 Flavin Reductases; Region: FlaRed; cl00801 1423891001983 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1423891001984 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 1423891001985 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 1423891001986 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 1423891001987 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1423891001988 active site 1423891001989 SAM binding site [chemical binding]; other site 1423891001990 homodimer interface [polypeptide binding]; other site 1423891001991 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1423891001992 active site 1423891001993 SAM binding site [chemical binding]; other site 1423891001994 homodimer interface [polypeptide binding]; other site 1423891001995 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1423891001996 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1423891001997 precorrin-3B synthase; Region: CobG; TIGR02435 1423891001998 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1423891001999 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1423891002000 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1423891002001 active site 1423891002002 SAM binding site [chemical binding]; other site 1423891002003 putative homodimer interface [polypeptide binding]; other site 1423891002004 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1423891002005 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1423891002006 S-adenosylmethionine binding site [chemical binding]; other site 1423891002007 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1423891002008 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 1423891002009 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1423891002010 MPN+ (JAMM) motif; other site 1423891002011 Zinc-binding site [ion binding]; other site 1423891002012 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1423891002013 active site 1423891002014 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1423891002015 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 1423891002016 Peptidase M15; Region: Peptidase_M15_3; cl01194 1423891002017 aminotransferase; Validated; Region: PRK09148 1423891002018 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1423891002019 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1423891002020 homodimer interface [polypeptide binding]; other site 1423891002021 catalytic residue [active] 1423891002022 homoserine dehydrogenase; Provisional; Region: PRK06349 1423891002023 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1423891002024 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1423891002025 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1423891002026 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1423891002027 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1423891002028 putative active site [active] 1423891002029 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1423891002030 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 1423891002031 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1423891002032 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1423891002033 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1423891002034 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1423891002035 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1423891002036 DHH family; Region: DHH; pfam01368 1423891002037 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 1423891002038 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1423891002039 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1423891002040 dimer interface [polypeptide binding]; other site 1423891002041 active site 1423891002042 metal binding site [ion binding]; metal-binding site 1423891002043 glutathione binding site [chemical binding]; other site 1423891002044 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1423891002045 DNA-binding site [nucleotide binding]; DNA binding site 1423891002046 RNA-binding motif; other site 1423891002047 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1423891002048 DNA-binding site [nucleotide binding]; DNA binding site 1423891002049 RNA-binding motif; other site 1423891002050 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1423891002051 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1423891002052 serine acetyltransferase; Provisional; Region: cysE; PRK11132 1423891002053 Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971 1423891002054 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1423891002055 trimer interface [polypeptide binding]; other site 1423891002056 active site 1423891002057 substrate binding site [chemical binding]; other site 1423891002058 CoA binding site [chemical binding]; other site 1423891002059 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1423891002060 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1423891002061 trimer interface [polypeptide binding]; other site 1423891002062 putative metal binding site [ion binding]; other site 1423891002063 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 1423891002064 PAS domain; Region: PAS_5; pfam07310 1423891002065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 1423891002066 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1423891002067 FOG: CBS domain [General function prediction only]; Region: COG0517 1423891002068 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1423891002069 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1423891002070 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1423891002071 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1423891002072 elongation factor Tu; Reviewed; Region: PRK00049 1423891002073 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1423891002074 G1 box; other site 1423891002075 GEF interaction site [polypeptide binding]; other site 1423891002076 GTP/Mg2+ binding site [chemical binding]; other site 1423891002077 Switch I region; other site 1423891002078 G2 box; other site 1423891002079 G3 box; other site 1423891002080 Switch II region; other site 1423891002081 G4 box; other site 1423891002082 G5 box; other site 1423891002083 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1423891002084 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1423891002085 Antibiotic Binding Site [chemical binding]; other site 1423891002086 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1423891002087 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1423891002088 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1423891002089 putative homodimer interface [polypeptide binding]; other site 1423891002090 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1423891002091 heterodimer interface [polypeptide binding]; other site 1423891002092 homodimer interface [polypeptide binding]; other site 1423891002093 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1423891002094 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1423891002095 23S rRNA interface [nucleotide binding]; other site 1423891002096 L7/L12 interface [polypeptide binding]; other site 1423891002097 putative thiostrepton binding site; other site 1423891002098 L25 interface [polypeptide binding]; other site 1423891002099 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1423891002100 mRNA/rRNA interface [nucleotide binding]; other site 1423891002101 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1423891002102 23S rRNA interface [nucleotide binding]; other site 1423891002103 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1423891002104 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1423891002105 L11 interface [polypeptide binding]; other site 1423891002106 putative EF-Tu interaction site [polypeptide binding]; other site 1423891002107 putative EF-G interaction site [polypeptide binding]; other site 1423891002108 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1423891002109 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1423891002110 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1423891002111 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1423891002112 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1423891002113 RPB11 interaction site [polypeptide binding]; other site 1423891002114 RPB12 interaction site [polypeptide binding]; other site 1423891002115 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1423891002116 RPB1 interaction site [polypeptide binding]; other site 1423891002117 RPB11 interaction site [polypeptide binding]; other site 1423891002118 RPB10 interaction site [polypeptide binding]; other site 1423891002119 RPB3 interaction site [polypeptide binding]; other site 1423891002120 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1423891002121 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1423891002122 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1423891002123 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1423891002124 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1423891002125 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1423891002126 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1423891002127 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1423891002128 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1423891002129 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1423891002130 DNA binding site [nucleotide binding] 1423891002131 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1423891002132 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1423891002133 S17 interaction site [polypeptide binding]; other site 1423891002134 S8 interaction site; other site 1423891002135 16S rRNA interaction site [nucleotide binding]; other site 1423891002136 streptomycin interaction site [chemical binding]; other site 1423891002137 23S rRNA interaction site [nucleotide binding]; other site 1423891002138 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1423891002139 30S ribosomal protein S7; Validated; Region: PRK05302 1423891002140 elongation factor G; Reviewed; Region: PRK00007 1423891002141 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1423891002142 G1 box; other site 1423891002143 putative GEF interaction site [polypeptide binding]; other site 1423891002144 GTP/Mg2+ binding site [chemical binding]; other site 1423891002145 Switch I region; other site 1423891002146 G2 box; other site 1423891002147 G3 box; other site 1423891002148 Switch II region; other site 1423891002149 G4 box; other site 1423891002150 G5 box; other site 1423891002151 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1423891002152 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1423891002153 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1423891002154 elongation factor Tu; Reviewed; Region: PRK00049 1423891002155 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1423891002156 G1 box; other site 1423891002157 GEF interaction site [polypeptide binding]; other site 1423891002158 GTP/Mg2+ binding site [chemical binding]; other site 1423891002159 Switch I region; other site 1423891002160 G2 box; other site 1423891002161 G3 box; other site 1423891002162 Switch II region; other site 1423891002163 G4 box; other site 1423891002164 G5 box; other site 1423891002165 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1423891002166 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1423891002167 Antibiotic Binding Site [chemical binding]; other site 1423891002168 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1423891002169 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1423891002170 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1423891002171 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1423891002172 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1423891002173 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1423891002174 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1423891002175 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1423891002176 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1423891002177 putative translocon binding site; other site 1423891002178 protein-rRNA interface [nucleotide binding]; other site 1423891002179 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1423891002180 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1423891002181 G-X-X-G motif; other site 1423891002182 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1423891002183 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1423891002184 23S rRNA interface [nucleotide binding]; other site 1423891002185 5S rRNA interface [nucleotide binding]; other site 1423891002186 putative antibiotic binding site [chemical binding]; other site 1423891002187 L25 interface [polypeptide binding]; other site 1423891002188 L27 interface [polypeptide binding]; other site 1423891002189 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1423891002190 23S rRNA interface [nucleotide binding]; other site 1423891002191 putative translocon interaction site; other site 1423891002192 signal recognition particle (SRP54) interaction site; other site 1423891002193 L23 interface [polypeptide binding]; other site 1423891002194 trigger factor interaction site; other site 1423891002195 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1423891002196 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1423891002197 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1423891002198 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1423891002199 RNA binding site [nucleotide binding]; other site 1423891002200 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1423891002201 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1423891002202 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1423891002203 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1423891002204 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1423891002205 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1423891002206 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1423891002207 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1423891002208 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1423891002209 5S rRNA interface [nucleotide binding]; other site 1423891002210 23S rRNA interface [nucleotide binding]; other site 1423891002211 L5 interface [polypeptide binding]; other site 1423891002212 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1423891002213 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1423891002214 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1423891002215 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1423891002216 23S rRNA binding site [nucleotide binding]; other site 1423891002217 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1423891002218 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1423891002219 SecY translocase; Region: SecY; pfam00344 1423891002220 adenylate kinase; Reviewed; Region: adk; PRK00279 1423891002221 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1423891002222 AMP-binding site [chemical binding]; other site 1423891002223 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1423891002224 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 1423891002225 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1423891002226 30S ribosomal protein S11; Validated; Region: PRK05309 1423891002227 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1423891002228 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1423891002229 alphaNTD homodimer interface [polypeptide binding]; other site 1423891002230 alphaNTD - beta interaction site [polypeptide binding]; other site 1423891002231 alphaNTD - beta' interaction site [polypeptide binding]; other site 1423891002232 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1423891002233 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1423891002234 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1423891002235 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1423891002236 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1423891002237 protein binding site [polypeptide binding]; other site 1423891002238 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1423891002239 protein binding site [polypeptide binding]; other site 1423891002240 recombination factor protein RarA; Reviewed; Region: PRK13342 1423891002241 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1423891002242 Walker A motif; other site 1423891002243 ATP binding site [chemical binding]; other site 1423891002244 Walker B motif; other site 1423891002245 arginine finger; other site 1423891002246 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1423891002247 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1423891002248 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1423891002249 catalytic residue [active] 1423891002250 putative outer membrane lipoprotein; Provisional; Region: PRK10510 1423891002251 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1423891002252 ligand binding site [chemical binding]; other site 1423891002253 recombinase A; Provisional; Region: recA; PRK09354 1423891002254 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1423891002255 hexamer interface [polypeptide binding]; other site 1423891002256 Walker A motif; other site 1423891002257 ATP binding site [chemical binding]; other site 1423891002258 Walker B motif; other site 1423891002259 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1423891002260 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1423891002261 motif 1; other site 1423891002262 active site 1423891002263 motif 2; other site 1423891002264 motif 3; other site 1423891002265 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1423891002266 alkaline phosphatase; Provisional; Region: PRK10518 1423891002267 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1423891002268 dimer interface [polypeptide binding]; other site 1423891002269 active site 1423891002270 isocitrate dehydrogenase; Validated; Region: PRK08299 1423891002271 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 1423891002272 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1423891002273 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 1423891002274 conserved cys residue [active] 1423891002275 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1423891002276 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1423891002277 glutamate racemase; Provisional; Region: PRK00865 1423891002278 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 1423891002279 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1423891002280 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 1423891002281 DctM-like transporters; Region: DctM; pfam06808 1423891002282 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1423891002283 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1423891002284 active site 1423891002285 substrate binding site [chemical binding]; other site 1423891002286 coenzyme B12 binding site [chemical binding]; other site 1423891002287 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1423891002288 B12 binding site [chemical binding]; other site 1423891002289 cobalt ligand [ion binding]; other site 1423891002290 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1423891002291 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1423891002292 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1423891002293 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1423891002294 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1423891002295 carboxyltransferase (CT) interaction site; other site 1423891002296 biotinylation site [posttranslational modification]; other site 1423891002297 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1423891002298 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1423891002299 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1423891002300 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1423891002301 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1423891002302 non-specific DNA binding site [nucleotide binding]; other site 1423891002303 salt bridge; other site 1423891002304 sequence-specific DNA binding site [nucleotide binding]; other site 1423891002305 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1423891002306 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1423891002307 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1423891002308 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 1423891002309 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1423891002310 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 1423891002311 DNA binding residues [nucleotide binding] 1423891002312 putative dimer interface [polypeptide binding]; other site 1423891002313 Predicted membrane protein [Function unknown]; Region: COG3503 1423891002314 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1423891002315 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1423891002316 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1423891002317 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1423891002318 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1423891002319 Sporulation related domain; Region: SPOR; pfam05036 1423891002320 Uncharacterized conserved protein [Function unknown]; Region: COG2127 1423891002321 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 1423891002322 Clp amino terminal domain; Region: Clp_N; pfam02861 1423891002323 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1423891002324 Walker A motif; other site 1423891002325 ATP binding site [chemical binding]; other site 1423891002326 Walker B motif; other site 1423891002327 arginine finger; other site 1423891002328 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1423891002329 Walker A motif; other site 1423891002330 ATP binding site [chemical binding]; other site 1423891002331 Walker B motif; other site 1423891002332 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1423891002333 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1423891002334 HIT family signature motif; other site 1423891002335 catalytic residue [active] 1423891002336 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_3; cd08585 1423891002337 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1423891002338 putative active site [active] 1423891002339 catalytic site [active] 1423891002340 putative metal binding site [ion binding]; other site 1423891002341 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1423891002342 homotrimer interaction site [polypeptide binding]; other site 1423891002343 putative active site [active] 1423891002344 Domain of unknown function (DUF1849); Region: DUF1849; pfam08904 1423891002345 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 1423891002346 SnoaL-like domain; Region: SnoaL_3; pfam13474 1423891002347 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1423891002348 rRNA interaction site [nucleotide binding]; other site 1423891002349 S8 interaction site; other site 1423891002350 putative laminin-1 binding site; other site 1423891002351 elongation factor Ts; Provisional; Region: tsf; PRK09377 1423891002352 UBA/TS-N domain; Region: UBA; pfam00627 1423891002353 Elongation factor TS; Region: EF_TS; pfam00889 1423891002354 Elongation factor TS; Region: EF_TS; pfam00889 1423891002355 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1423891002356 putative nucleotide binding site [chemical binding]; other site 1423891002357 uridine monophosphate binding site [chemical binding]; other site 1423891002358 homohexameric interface [polypeptide binding]; other site 1423891002359 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1423891002360 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1423891002361 hinge region; other site 1423891002362 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1423891002363 catalytic residue [active] 1423891002364 putative FPP diphosphate binding site; other site 1423891002365 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240 1423891002366 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1423891002367 dimer interface [polypeptide binding]; other site 1423891002368 putative IPP diphosphate binding site; other site 1423891002369 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1423891002370 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1423891002371 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1423891002372 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1423891002373 active site 1423891002374 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1423891002375 protein binding site [polypeptide binding]; other site 1423891002376 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1423891002377 putative substrate binding region [chemical binding]; other site 1423891002378 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1423891002379 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1423891002380 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1423891002381 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1423891002382 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1423891002383 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1423891002384 Surface antigen; Region: Bac_surface_Ag; pfam01103 1423891002385 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1423891002386 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1423891002387 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1423891002388 trimer interface [polypeptide binding]; other site 1423891002389 active site 1423891002390 UDP-GlcNAc binding site [chemical binding]; other site 1423891002391 lipid binding site [chemical binding]; lipid-binding site 1423891002392 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1423891002393 Acyl-[acyl carrier protein]; Region: LpxA; COG1043 1423891002394 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1423891002395 active site 1423891002396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3494 1423891002397 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 1423891002398 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1423891002399 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1423891002400 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1423891002401 dimer interface [polypeptide binding]; other site 1423891002402 active site 1423891002403 citrylCoA binding site [chemical binding]; other site 1423891002404 NADH binding [chemical binding]; other site 1423891002405 cationic pore residues; other site 1423891002406 oxalacetate/citrate binding site [chemical binding]; other site 1423891002407 coenzyme A binding site [chemical binding]; other site 1423891002408 catalytic triad [active] 1423891002409 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1423891002410 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1423891002411 active site 1423891002412 HIGH motif; other site 1423891002413 nucleotide binding site [chemical binding]; other site 1423891002414 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1423891002415 active site 1423891002416 KMSKS motif; other site 1423891002417 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1423891002418 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1423891002419 Competence protein; Region: Competence; pfam03772 1423891002420 LexA repressor; Validated; Region: PRK00215 1423891002421 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1423891002422 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1423891002423 Catalytic site [active] 1423891002424 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1423891002425 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1423891002426 dimer interface [polypeptide binding]; other site 1423891002427 putative functional site; other site 1423891002428 putative MPT binding site; other site 1423891002429 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1423891002430 trimer interface [polypeptide binding]; other site 1423891002431 dimer interface [polypeptide binding]; other site 1423891002432 putative active site [active] 1423891002433 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1423891002434 active site 1423891002435 ribulose/triose binding site [chemical binding]; other site 1423891002436 phosphate binding site [ion binding]; other site 1423891002437 substrate (anthranilate) binding pocket [chemical binding]; other site 1423891002438 product (indole) binding pocket [chemical binding]; other site 1423891002439 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1423891002440 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1423891002441 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1423891002442 SurA N-terminal domain; Region: SurA_N_3; cl07813 1423891002443 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1423891002444 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1423891002445 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1423891002446 triosephosphate isomerase; Provisional; Region: PRK14565 1423891002447 substrate binding site [chemical binding]; other site 1423891002448 dimer interface [polypeptide binding]; other site 1423891002449 catalytic triad [active] 1423891002450 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 1423891002451 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1423891002452 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1423891002453 CTP synthetase; Validated; Region: pyrG; PRK05380 1423891002454 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1423891002455 Catalytic site [active] 1423891002456 active site 1423891002457 UTP binding site [chemical binding]; other site 1423891002458 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1423891002459 active site 1423891002460 putative oxyanion hole; other site 1423891002461 catalytic triad [active] 1423891002462 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1423891002463 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1423891002464 enolase; Provisional; Region: eno; PRK00077 1423891002465 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1423891002466 dimer interface [polypeptide binding]; other site 1423891002467 metal binding site [ion binding]; metal-binding site 1423891002468 substrate binding pocket [chemical binding]; other site 1423891002469 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1423891002470 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1423891002471 S-adenosylmethionine binding site [chemical binding]; other site 1423891002472 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1423891002473 Septum formation initiator; Region: DivIC; pfam04977 1423891002474 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1423891002475 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1423891002476 tetramer interface [polypeptide binding]; other site 1423891002477 TPP-binding site [chemical binding]; other site 1423891002478 heterodimer interface [polypeptide binding]; other site 1423891002479 phosphorylation loop region [posttranslational modification] 1423891002480 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 1423891002481 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1423891002482 E3 interaction surface; other site 1423891002483 lipoyl attachment site [posttranslational modification]; other site 1423891002484 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1423891002485 alpha subunit interface [polypeptide binding]; other site 1423891002486 TPP binding site [chemical binding]; other site 1423891002487 heterodimer interface [polypeptide binding]; other site 1423891002488 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1423891002489 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1423891002490 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 1423891002491 E3 interaction surface; other site 1423891002492 lipoyl attachment site [posttranslational modification]; other site 1423891002493 e3 binding domain; Region: E3_binding; pfam02817 1423891002494 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1423891002495 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1423891002496 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1423891002497 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1423891002498 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1423891002499 lipoyl synthase; Provisional; Region: PRK05481 1423891002500 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1423891002501 FeS/SAM binding site; other site 1423891002502 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1423891002503 putative coenzyme Q binding site [chemical binding]; other site 1423891002504 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1423891002505 classical (c) SDRs; Region: SDR_c; cd05233 1423891002506 NAD(P) binding site [chemical binding]; other site 1423891002507 active site 1423891002508 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 1423891002509 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 1423891002510 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1423891002511 substrate binding site; other site 1423891002512 dimer interface; other site 1423891002513 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1423891002514 homotrimer interaction site [polypeptide binding]; other site 1423891002515 zinc binding site [ion binding]; other site 1423891002516 CDP-binding sites; other site 1423891002517 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1423891002518 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1423891002519 dimer interface [polypeptide binding]; other site 1423891002520 phosphorylation site [posttranslational modification] 1423891002521 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1423891002522 ATP binding site [chemical binding]; other site 1423891002523 Mg2+ binding site [ion binding]; other site 1423891002524 G-X-G motif; other site 1423891002525 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 1423891002526 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1423891002527 active site 1423891002528 phosphorylation site [posttranslational modification] 1423891002529 intermolecular recognition site; other site 1423891002530 dimerization interface [polypeptide binding]; other site 1423891002531 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1423891002532 Walker A motif; other site 1423891002533 ATP binding site [chemical binding]; other site 1423891002534 Walker B motif; other site 1423891002535 arginine finger; other site 1423891002536 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1423891002537 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 1423891002538 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1423891002539 dimerization interface [polypeptide binding]; other site 1423891002540 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1423891002541 dimer interface [polypeptide binding]; other site 1423891002542 phosphorylation site [posttranslational modification] 1423891002543 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1423891002544 ATP binding site [chemical binding]; other site 1423891002545 Mg2+ binding site [ion binding]; other site 1423891002546 G-X-G motif; other site 1423891002547 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1423891002548 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1423891002549 active site 1423891002550 phosphorylation site [posttranslational modification] 1423891002551 intermolecular recognition site; other site 1423891002552 dimerization interface [polypeptide binding]; other site 1423891002553 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1423891002554 Walker A motif; other site 1423891002555 ATP binding site [chemical binding]; other site 1423891002556 Walker B motif; other site 1423891002557 arginine finger; other site 1423891002558 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1423891002559 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1423891002560 TrkA-N domain; Region: TrkA_N; pfam02254 1423891002561 TrkA-C domain; Region: TrkA_C; pfam02080 1423891002562 TrkA-N domain; Region: TrkA_N; pfam02254 1423891002563 TrkA-C domain; Region: TrkA_C; pfam02080 1423891002564 bacterial Hfq-like; Region: Hfq; cd01716 1423891002565 hexamer interface [polypeptide binding]; other site 1423891002566 Sm1 motif; other site 1423891002567 RNA binding site [nucleotide binding]; other site 1423891002568 Sm2 motif; other site 1423891002569 GTPases [General function prediction only]; Region: HflX; COG2262 1423891002570 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1423891002571 HflX GTPase family; Region: HflX; cd01878 1423891002572 G1 box; other site 1423891002573 GTP/Mg2+ binding site [chemical binding]; other site 1423891002574 Switch I region; other site 1423891002575 G2 box; other site 1423891002576 G3 box; other site 1423891002577 Switch II region; other site 1423891002578 G4 box; other site 1423891002579 G5 box; other site 1423891002580 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1423891002581 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1423891002582 oligomer interface [polypeptide binding]; other site 1423891002583 active site residues [active] 1423891002584 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1423891002585 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1423891002586 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1423891002587 Walker A motif; other site 1423891002588 ATP binding site [chemical binding]; other site 1423891002589 Walker B motif; other site 1423891002590 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1423891002591 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1423891002592 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1423891002593 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1423891002594 Walker A motif; other site 1423891002595 ATP binding site [chemical binding]; other site 1423891002596 Walker B motif; other site 1423891002597 arginine finger; other site 1423891002598 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1423891002599 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1423891002600 IHF dimer interface [polypeptide binding]; other site 1423891002601 IHF - DNA interface [nucleotide binding]; other site 1423891002602 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1423891002603 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1423891002604 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1423891002605 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1423891002606 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1423891002607 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1423891002608 dimer interface [polypeptide binding]; other site 1423891002609 ssDNA binding site [nucleotide binding]; other site 1423891002610 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1423891002611 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 1423891002612 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1423891002613 DNA-binding site [nucleotide binding]; DNA binding site 1423891002614 UTRA domain; Region: UTRA; pfam07702 1423891002615 Uncharacterized component of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3709 1423891002616 DNA gyrase subunit A; Validated; Region: PRK05560 1423891002617 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1423891002618 CAP-like domain; other site 1423891002619 active site 1423891002620 primary dimer interface [polypeptide binding]; other site 1423891002621 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1423891002622 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1423891002623 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1423891002624 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1423891002625 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1423891002626 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1423891002627 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1423891002628 active site 1423891002629 (T/H)XGH motif; other site 1423891002630 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1423891002631 active site 1423891002632 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1423891002633 active site 1423891002634 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1423891002635 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1423891002636 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1423891002637 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1423891002638 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1423891002639 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1423891002640 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1423891002641 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1423891002642 HlyD family secretion protein; Region: HlyD_3; pfam13437 1423891002643 multidrug efflux protein; Reviewed; Region: PRK09579 1423891002644 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1423891002645 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1423891002646 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 1423891002647 dimerization interface [polypeptide binding]; other site 1423891002648 substrate binding pocket [chemical binding]; other site 1423891002649 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 1423891002650 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1423891002651 FAD binding site [chemical binding]; other site 1423891002652 substrate binding pocket [chemical binding]; other site 1423891002653 catalytic base [active] 1423891002654 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1423891002655 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1423891002656 Prophage antirepressor [Transcription]; Region: COG3617 1423891002657 BRO family, N-terminal domain; Region: Bro-N; smart01040 1423891002658 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1423891002659 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1423891002660 catalytic residues [active] 1423891002661 catalytic nucleophile [active] 1423891002662 Presynaptic Site I dimer interface [polypeptide binding]; other site 1423891002663 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1423891002664 Synaptic Flat tetramer interface [polypeptide binding]; other site 1423891002665 Synaptic Site I dimer interface [polypeptide binding]; other site 1423891002666 DNA binding site [nucleotide binding] 1423891002667 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1423891002668 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1423891002669 active site 1423891002670 DNA binding site [nucleotide binding] 1423891002671 Int/Topo IB signature motif; other site 1423891002672 hypothetical protein; Provisional; Region: PRK10279 1423891002673 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1423891002674 nucleophile elbow; other site 1423891002675 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1423891002676 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1423891002677 homodecamer interface [polypeptide binding]; other site 1423891002678 GTP cyclohydrolase I; Provisional; Region: PLN03044 1423891002679 active site 1423891002680 putative catalytic site residues [active] 1423891002681 zinc binding site [ion binding]; other site 1423891002682 GTP-CH-I/GFRP interaction surface; other site 1423891002683 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1423891002684 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1423891002685 trimerization site [polypeptide binding]; other site 1423891002686 active site 1423891002687 hypothetical protein; Validated; Region: PRK00041 1423891002688 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1423891002689 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1423891002690 Sporulation related domain; Region: SPOR; pfam05036 1423891002691 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1423891002692 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1423891002693 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1423891002694 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1423891002695 active site 1423891002696 dimer interface [polypeptide binding]; other site 1423891002697 motif 1; other site 1423891002698 motif 2; other site 1423891002699 motif 3; other site 1423891002700 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1423891002701 anticodon binding site; other site 1423891002702 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1423891002703 putative FMN binding site [chemical binding]; other site 1423891002704 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1423891002705 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1423891002706 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1423891002707 homodimer interface [polypeptide binding]; other site 1423891002708 metal binding site [ion binding]; metal-binding site 1423891002709 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1423891002710 homodimer interface [polypeptide binding]; other site 1423891002711 active site 1423891002712 putative chemical substrate binding site [chemical binding]; other site 1423891002713 metal binding site [ion binding]; metal-binding site 1423891002714 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1423891002715 active site 1423891002716 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1423891002717 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1423891002718 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 1423891002719 Tetratricopeptide repeat; Region: TPR_1; pfam00515 1423891002720 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1423891002721 S-adenosylmethionine binding site [chemical binding]; other site 1423891002722 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1423891002723 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1423891002724 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 1423891002725 active site 1423891002726 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1423891002727 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 1423891002728 putative NAD(P) binding site [chemical binding]; other site 1423891002729 putative substrate binding site [chemical binding]; other site 1423891002730 catalytic Zn binding site [ion binding]; other site 1423891002731 structural Zn binding site [ion binding]; other site 1423891002732 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1423891002733 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1423891002734 HlyD family secretion protein; Region: HlyD_3; pfam13437 1423891002735 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1423891002736 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1423891002737 putative substrate translocation pore; other site 1423891002738 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1423891002739 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1423891002740 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1423891002741 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1423891002742 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1423891002743 metal binding site [ion binding]; metal-binding site 1423891002744 active site 1423891002745 I-site; other site 1423891002746 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1423891002747 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1423891002748 Coenzyme A binding pocket [chemical binding]; other site 1423891002749 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1423891002750 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1423891002751 active site residue [active] 1423891002752 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1423891002753 active site residue [active] 1423891002754 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 1423891002755 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1423891002756 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1423891002757 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1423891002758 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1423891002759 dimer interface [polypeptide binding]; other site 1423891002760 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1423891002761 catalytic residue [active] 1423891002762 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1423891002763 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1423891002764 ATP binding site [chemical binding]; other site 1423891002765 Mg++ binding site [ion binding]; other site 1423891002766 motif III; other site 1423891002767 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1423891002768 nucleotide binding region [chemical binding]; other site 1423891002769 ATP-binding site [chemical binding]; other site 1423891002770 threonine dehydratase; Validated; Region: PRK08639 1423891002771 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1423891002772 tetramer interface [polypeptide binding]; other site 1423891002773 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1423891002774 catalytic residue [active] 1423891002775 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1423891002776 putative Ile/Val binding site [chemical binding]; other site 1423891002777 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 1423891002778 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1423891002779 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 1423891002780 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1423891002781 putative MPT binding site; other site 1423891002782 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1423891002783 Ligand Binding Site [chemical binding]; other site 1423891002784 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1423891002785 active site 1423891002786 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 1423891002787 nudix motif; other site 1423891002788 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 1423891002789 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 1423891002790 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1423891002791 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1423891002792 active site 1423891002793 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1423891002794 TSCPD domain; Region: TSCPD; pfam12637 1423891002795 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1423891002796 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1423891002797 Beta-lactamase; Region: Beta-lactamase; pfam00144 1423891002798 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1423891002799 Predicted flavoproteins [General function prediction only]; Region: COG2081 1423891002800 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1423891002801 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1423891002802 PAS domain; Region: PAS_9; pfam13426 1423891002803 putative active site [active] 1423891002804 heme pocket [chemical binding]; other site 1423891002805 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1423891002806 PAS fold; Region: PAS_4; pfam08448 1423891002807 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1423891002808 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1423891002809 dimer interface [polypeptide binding]; other site 1423891002810 phosphorylation site [posttranslational modification] 1423891002811 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1423891002812 ATP binding site [chemical binding]; other site 1423891002813 Mg2+ binding site [ion binding]; other site 1423891002814 G-X-G motif; other site 1423891002815 Response regulator receiver domain; Region: Response_reg; pfam00072 1423891002816 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1423891002817 active site 1423891002818 phosphorylation site [posttranslational modification] 1423891002819 intermolecular recognition site; other site 1423891002820 dimerization interface [polypeptide binding]; other site 1423891002821 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 1423891002822 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 1423891002823 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1423891002824 catalytic core [active] 1423891002825 Predicted membrane protein [Function unknown]; Region: COG3768 1423891002826 Domain of unknown function (DUF697); Region: DUF697; cl12064 1423891002827 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1423891002828 catalytic center binding site [active] 1423891002829 ATP binding site [chemical binding]; other site 1423891002830 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1423891002831 homooctamer interface [polypeptide binding]; other site 1423891002832 active site 1423891002833 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1423891002834 dihydropteroate synthase; Region: DHPS; TIGR01496 1423891002835 substrate binding pocket [chemical binding]; other site 1423891002836 dimer interface [polypeptide binding]; other site 1423891002837 inhibitor binding site; inhibition site 1423891002838 Predicted secreted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5661 1423891002839 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1423891002840 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1423891002841 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1423891002842 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1423891002843 catalytic loop [active] 1423891002844 iron binding site [ion binding]; other site 1423891002845 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1423891002846 ABC-type uncharacterized transport system, auxiliary component [General function prediction only]; Region: COG3218 1423891002847 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 1423891002848 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1423891002849 mce related protein; Region: MCE; pfam02470 1423891002850 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1423891002851 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1423891002852 Walker A/P-loop; other site 1423891002853 ATP binding site [chemical binding]; other site 1423891002854 Q-loop/lid; other site 1423891002855 ABC transporter signature motif; other site 1423891002856 Walker B; other site 1423891002857 D-loop; other site 1423891002858 H-loop/switch region; other site 1423891002859 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1423891002860 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1423891002861 Permease; Region: Permease; pfam02405 1423891002862 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 1423891002863 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1423891002864 active site 1423891002865 malic enzyme; Reviewed; Region: PRK12862 1423891002866 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1423891002867 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1423891002868 putative NAD(P) binding site [chemical binding]; other site 1423891002869 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1423891002870 NAD synthetase; Provisional; Region: PRK13981 1423891002871 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1423891002872 multimer interface [polypeptide binding]; other site 1423891002873 active site 1423891002874 catalytic triad [active] 1423891002875 protein interface 1 [polypeptide binding]; other site 1423891002876 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1423891002877 homodimer interface [polypeptide binding]; other site 1423891002878 NAD binding pocket [chemical binding]; other site 1423891002879 ATP binding pocket [chemical binding]; other site 1423891002880 Mg binding site [ion binding]; other site 1423891002881 active-site loop [active] 1423891002882 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1423891002883 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1423891002884 glutathione reductase; Validated; Region: PRK06116 1423891002885 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1423891002886 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1423891002887 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1423891002888 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1423891002889 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1423891002890 active site 1423891002891 dimer interface [polypeptide binding]; other site 1423891002892 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1423891002893 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1423891002894 motif II; other site 1423891002895 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1423891002896 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1423891002897 putative substrate binding site [chemical binding]; other site 1423891002898 putative ATP binding site [chemical binding]; other site 1423891002899 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1423891002900 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1423891002901 glutamine synthetase; Provisional; Region: glnA; PRK09469 1423891002902 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1423891002903 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1423891002904 Chaperone required for the assembly of the mitochondrial F1-ATPase [Posttranslational modification, protein turnover, chaperones]; Region: COG5387 1423891002905 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1423891002906 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1423891002907 motif I; other site 1423891002908 active site 1423891002909 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1423891002910 motif II; other site 1423891002911 EamA-like transporter family; Region: EamA; pfam00892 1423891002912 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1423891002913 EamA-like transporter family; Region: EamA; pfam00892 1423891002914 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1423891002915 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1423891002916 active site 1423891002917 cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657 1423891002918 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1423891002919 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1423891002920 Walker A/P-loop; other site 1423891002921 ATP binding site [chemical binding]; other site 1423891002922 Q-loop/lid; other site 1423891002923 ABC transporter signature motif; other site 1423891002924 Walker B; other site 1423891002925 D-loop; other site 1423891002926 H-loop/switch region; other site 1423891002927 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1423891002928 putative hydrolase; Provisional; Region: PRK02113 1423891002929 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1423891002930 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1423891002931 active site 1423891002932 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 1423891002933 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1423891002934 active site 1423891002935 HIGH motif; other site 1423891002936 KMSKS motif; other site 1423891002937 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1423891002938 tRNA binding surface [nucleotide binding]; other site 1423891002939 anticodon binding site; other site 1423891002940 DNA polymerase III subunit delta'; Validated; Region: PRK09112 1423891002941 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1423891002942 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1423891002943 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1423891002944 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1423891002945 TMP-binding site; other site 1423891002946 ATP-binding site [chemical binding]; other site 1423891002947 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1423891002948 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1423891002949 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1423891002950 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1423891002951 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1423891002952 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1423891002953 ArsC family; Region: ArsC; pfam03960 1423891002954 catalytic residues [active] 1423891002955 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 1423891002956 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 1423891002957 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 1423891002958 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1423891002959 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1423891002960 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1423891002961 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1423891002962 Phage portal protein; Region: Phage_portal; pfam04860 1423891002963 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 1423891002964 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1423891002965 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1423891002966 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1423891002967 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1423891002968 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 1423891002969 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1423891002970 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1423891002971 active site 1423891002972 Int/Topo IB signature motif; other site 1423891002973 catalytic residues [active] 1423891002974 DNA binding site [nucleotide binding] 1423891002975 Transglycosylase associated protein; Region: Transgly_assoc; pfam04226 1423891002976 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 1423891002977 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1423891002978 fumarate hydratase; Provisional; Region: PRK15389 1423891002979 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 1423891002980 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1423891002981 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1423891002982 hypothetical protein; Provisional; Region: PRK06753 1423891002983 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 1423891002984 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 1423891002985 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1423891002986 FeS/SAM binding site; other site 1423891002987 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1423891002988 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1423891002989 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1423891002990 GTP binding site; other site 1423891002991 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1423891002992 Walker A motif; other site 1423891002993 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1423891002994 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1423891002995 substrate binding pocket [chemical binding]; other site 1423891002996 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1423891002997 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1423891002998 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1423891002999 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1423891003000 HIGH motif; other site 1423891003001 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1423891003002 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1423891003003 active site 1423891003004 KMSKS motif; other site 1423891003005 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1423891003006 tRNA binding surface [nucleotide binding]; other site 1423891003007 anticodon binding site; other site 1423891003008 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1423891003009 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1423891003010 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 1423891003011 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1423891003012 S-adenosylmethionine binding site [chemical binding]; other site 1423891003013 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 1423891003014 metal-binding site [ion binding] 1423891003015 FeS assembly scaffold SufA; Region: sufA_proteo; TIGR01997 1423891003016 helicase 45; Provisional; Region: PTZ00424 1423891003017 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1423891003018 ATP binding site [chemical binding]; other site 1423891003019 Mg++ binding site [ion binding]; other site 1423891003020 motif III; other site 1423891003021 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1423891003022 nucleotide binding region [chemical binding]; other site 1423891003023 ATP-binding site [chemical binding]; other site 1423891003024 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1423891003025 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 1423891003026 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1423891003027 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1423891003028 active site 1423891003029 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1423891003030 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 1423891003031 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1423891003032 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1423891003033 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1423891003034 catalytic residue [active] 1423891003035 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1423891003036 FeS assembly protein SufD; Region: sufD; TIGR01981 1423891003037 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1423891003038 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1423891003039 Walker A/P-loop; other site 1423891003040 ATP binding site [chemical binding]; other site 1423891003041 Q-loop/lid; other site 1423891003042 ABC transporter signature motif; other site 1423891003043 Walker B; other site 1423891003044 D-loop; other site 1423891003045 H-loop/switch region; other site 1423891003046 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1423891003047 putative ABC transporter; Region: ycf24; CHL00085 1423891003048 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1423891003049 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1423891003050 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1423891003051 catalytic residue [active] 1423891003052 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 1423891003053 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1423891003054 Predicted molecular chaperone distantly related to HSP70-fold metalloproteases [Posttranslational modification, protein turnover, chaperones]; Region: COG2377 1423891003055 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1423891003056 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1423891003057 active site 1423891003058 HIGH motif; other site 1423891003059 dimer interface [polypeptide binding]; other site 1423891003060 KMSKS motif; other site 1423891003061 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1423891003062 RNA binding surface [nucleotide binding]; other site 1423891003063 AsmA family; Region: AsmA; pfam05170 1423891003064 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1423891003065 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1423891003066 catalytic triad [active] 1423891003067 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 1423891003068 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1423891003069 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1423891003070 peptide chain release factor 2; Provisional; Region: PRK07342 1423891003071 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1423891003072 RF-1 domain; Region: RF-1; pfam00472 1423891003073 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 1423891003074 Transglycosylase; Region: Transgly; pfam00912 1423891003075 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1423891003076 AMIN domain; Region: AMIN; pfam11741 1423891003077 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1423891003078 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1423891003079 active site 1423891003080 metal binding site [ion binding]; metal-binding site 1423891003081 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1423891003082 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1423891003083 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 1423891003084 aspartate aminotransferase; Provisional; Region: PRK05764 1423891003085 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1423891003086 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1423891003087 homodimer interface [polypeptide binding]; other site 1423891003088 catalytic residue [active] 1423891003089 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 1423891003090 Peptidase family M48; Region: Peptidase_M48; cl12018 1423891003091 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1423891003092 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 1423891003093 catalytic residues [active] 1423891003094 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1423891003095 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1423891003096 trimer interface [polypeptide binding]; other site 1423891003097 active site 1423891003098 dimer interface [polypeptide binding]; other site 1423891003099 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1423891003100 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1423891003101 carboxyltransferase (CT) interaction site; other site 1423891003102 biotinylation site [posttranslational modification]; other site 1423891003103 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1423891003104 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1423891003105 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1423891003106 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1423891003107 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1423891003108 NADH dehydrogenase; Validated; Region: PRK08183 1423891003109 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1423891003110 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1423891003111 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1423891003112 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1423891003113 GatB domain; Region: GatB_Yqey; smart00845 1423891003114 trigger factor; Provisional; Region: tig; PRK01490 1423891003115 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1423891003116 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1423891003117 Uncharacterized membrane-anchored protein [Function unknown]; Region: COG4929 1423891003118 Predicted membrane protein [Function unknown]; Region: COG4872 1423891003119 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1423891003120 Glucose inhibited division protein A; Region: GIDA; pfam01134 1423891003121 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 1423891003122 substrate binding pocket [chemical binding]; other site 1423891003123 substrate-Mg2+ binding site; other site 1423891003124 aspartate-rich region 1; other site 1423891003125 aspartate-rich region 2; other site 1423891003126 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 1423891003127 Preprotein translocase subunit YajC [Intracellular trafficking and secretion]; Region: YajC; COG1862 1423891003128 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 1423891003129 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1423891003130 Walker A motif; other site 1423891003131 ATP binding site [chemical binding]; other site 1423891003132 Walker B motif; other site 1423891003133 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1423891003134 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1423891003135 Peptidase family M23; Region: Peptidase_M23; pfam01551 1423891003136 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 1423891003137 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1423891003138 S-adenosylmethionine binding site [chemical binding]; other site 1423891003139 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1423891003140 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1423891003141 sec-independent translocase; Provisional; Region: PRK00708 1423891003142 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 1423891003143 twin arginine translocase protein A; Provisional; Region: tatA; PRK00720 1423891003144 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 1423891003145 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1423891003146 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1423891003147 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1423891003148 Sporulation related domain; Region: SPOR; pfam05036 1423891003149 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 1423891003150 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1423891003151 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1423891003152 active site 1423891003153 HIGH motif; other site 1423891003154 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1423891003155 KMSK motif region; other site 1423891003156 tRNA binding surface [nucleotide binding]; other site 1423891003157 DALR anticodon binding domain; Region: DALR_1; smart00836 1423891003158 anticodon binding site; other site 1423891003159 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 1423891003160 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1423891003161 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1423891003162 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 1423891003163 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 1423891003164 putative metal binding site [ion binding]; other site 1423891003165 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1423891003166 putative catalytic site [active] 1423891003167 putative phosphate binding site [ion binding]; other site 1423891003168 active site 1423891003169 metal binding site A [ion binding]; metal-binding site 1423891003170 DNA binding site [nucleotide binding] 1423891003171 putative AP binding site [nucleotide binding]; other site 1423891003172 putative metal binding site B [ion binding]; other site 1423891003173 Staphylococcal nuclease homologues; Region: SNc; smart00318 1423891003174 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 1423891003175 Catalytic site; other site 1423891003176 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 1423891003177 putative uracil binding site [chemical binding]; other site 1423891003178 putative active site [active] 1423891003179 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1423891003180 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1423891003181 putative DNA binding site [nucleotide binding]; other site 1423891003182 putative Zn2+ binding site [ion binding]; other site 1423891003183 AsnC family; Region: AsnC_trans_reg; pfam01037 1423891003184 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1423891003185 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1423891003186 putative dimer interface [polypeptide binding]; other site 1423891003187 active site pocket [active] 1423891003188 putative cataytic base [active] 1423891003189 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1423891003190 Predicted aspartyl protease [General function prediction only]; Region: COG3577 1423891003191 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 1423891003192 catalytic motif [active] 1423891003193 Catalytic residue [active] 1423891003194 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1423891003195 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1423891003196 FMN binding site [chemical binding]; other site 1423891003197 active site 1423891003198 catalytic residues [active] 1423891003199 substrate binding site [chemical binding]; other site 1423891003200 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1423891003201 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1423891003202 substrate binding pocket [chemical binding]; other site 1423891003203 membrane-bound complex binding site; other site 1423891003204 hinge residues; other site 1423891003205 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1423891003206 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1423891003207 active site 1423891003208 motif I; other site 1423891003209 motif II; other site 1423891003210 Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454 1423891003211 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1423891003212 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 1423891003213 active site 1423891003214 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 1423891003215 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1423891003216 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1423891003217 substrate binding site [chemical binding]; other site 1423891003218 ATP binding site [chemical binding]; other site 1423891003219 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1423891003220 active site 1423891003221 catalytic residues [active] 1423891003222 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 1423891003223 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 1423891003224 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 1423891003225 acyl carrier protein; Provisional; Region: PRK06508 1423891003226 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519 1423891003227 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1423891003228 active site 1423891003229 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501 1423891003230 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1423891003231 dimer interface [polypeptide binding]; other site 1423891003232 active site 1423891003233 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1423891003234 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266 1423891003235 putative NAD(P) binding site [chemical binding]; other site 1423891003236 structural Zn binding site [ion binding]; other site 1423891003237 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1423891003238 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1423891003239 putative acyl-acceptor binding pocket; other site 1423891003240 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1423891003241 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1423891003242 substrate binding site [chemical binding]; other site 1423891003243 hexamer interface [polypeptide binding]; other site 1423891003244 metal binding site [ion binding]; metal-binding site 1423891003245 adenylosuccinate lyase; Provisional; Region: PRK07492 1423891003246 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1423891003247 tetramer interface [polypeptide binding]; other site 1423891003248 active site 1423891003249 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1423891003250 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1423891003251 putative metal binding site [ion binding]; other site 1423891003252 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1423891003253 active site 1423891003254 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 1423891003255 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1423891003256 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 1423891003257 Uncharacterized conserved protein [Function unknown]; Region: COG5467 1423891003258 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1423891003259 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1423891003260 ATP binding site [chemical binding]; other site 1423891003261 active site 1423891003262 substrate binding site [chemical binding]; other site 1423891003263 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1423891003264 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1423891003265 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1423891003266 putative active site [active] 1423891003267 catalytic triad [active] 1423891003268 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1423891003269 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1423891003270 C-terminal domain interface [polypeptide binding]; other site 1423891003271 GSH binding site (G-site) [chemical binding]; other site 1423891003272 dimer interface [polypeptide binding]; other site 1423891003273 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 1423891003274 N-terminal domain interface [polypeptide binding]; other site 1423891003275 dimer interface [polypeptide binding]; other site 1423891003276 substrate binding pocket (H-site) [chemical binding]; other site 1423891003277 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1423891003278 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1423891003279 dimerization interface [polypeptide binding]; other site 1423891003280 ATP binding site [chemical binding]; other site 1423891003281 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1423891003282 dimerization interface [polypeptide binding]; other site 1423891003283 ATP binding site [chemical binding]; other site 1423891003284 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 1423891003285 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1423891003286 putative GSH binding site [chemical binding]; other site 1423891003287 catalytic residues [active] 1423891003288 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1423891003289 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1423891003290 putative substrate translocation pore; other site 1423891003291 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1423891003292 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 1423891003293 active site 1423891003294 putative lithium-binding site [ion binding]; other site 1423891003295 substrate binding site [chemical binding]; other site 1423891003296 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1423891003297 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1423891003298 Ligand Binding Site [chemical binding]; other site 1423891003299 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1423891003300 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1423891003301 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1423891003302 RNA binding surface [nucleotide binding]; other site 1423891003303 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1423891003304 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1423891003305 putative active site [active] 1423891003306 putative PHP Thumb interface [polypeptide binding]; other site 1423891003307 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1423891003308 generic binding surface II; other site 1423891003309 generic binding surface I; other site 1423891003310 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1423891003311 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1423891003312 Walker A/P-loop; other site 1423891003313 ATP binding site [chemical binding]; other site 1423891003314 Q-loop/lid; other site 1423891003315 ABC transporter signature motif; other site 1423891003316 Walker B; other site 1423891003317 D-loop; other site 1423891003318 H-loop/switch region; other site 1423891003319 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 1423891003320 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1423891003321 FtsX-like permease family; Region: FtsX; pfam02687 1423891003322 prolyl-tRNA synthetase; Provisional; Region: PRK12325 1423891003323 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1423891003324 dimer interface [polypeptide binding]; other site 1423891003325 motif 1; other site 1423891003326 active site 1423891003327 motif 2; other site 1423891003328 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1423891003329 active site 1423891003330 motif 3; other site 1423891003331 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1423891003332 anticodon binding site; other site 1423891003333 Predicted secreted protein [Function unknown]; Region: COG5454 1423891003334 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1423891003335 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1423891003336 dimer interface [polypeptide binding]; other site 1423891003337 substrate binding site [chemical binding]; other site 1423891003338 metal binding site [ion binding]; metal-binding site 1423891003339 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1423891003340 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1423891003341 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1423891003342 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1423891003343 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1423891003344 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1423891003345 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1423891003346 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1423891003347 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1423891003348 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1423891003349 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1423891003350 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1423891003351 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1423891003352 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1423891003353 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1423891003354 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 1423891003355 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1423891003356 4Fe-4S binding domain; Region: Fer4; pfam00037 1423891003357 4Fe-4S binding domain; Region: Fer4; pfam00037 1423891003358 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1423891003359 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1423891003360 NADH dehydrogenase subunit G; Validated; Region: PRK09130 1423891003361 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1423891003362 catalytic loop [active] 1423891003363 iron binding site [ion binding]; other site 1423891003364 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1423891003365 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 1423891003366 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 1423891003367 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 1423891003368 SLBB domain; Region: SLBB; pfam10531 1423891003369 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1423891003370 NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905 1423891003371 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1423891003372 putative dimer interface [polypeptide binding]; other site 1423891003373 [2Fe-2S] cluster binding site [ion binding]; other site 1423891003374 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1423891003375 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1423891003376 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 1423891003377 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1423891003378 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 1423891003379 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1423891003380 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1423891003381 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994 1423891003382 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1423891003383 homodimer interface [polypeptide binding]; other site 1423891003384 substrate-cofactor binding pocket; other site 1423891003385 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1423891003386 catalytic residue [active] 1423891003387 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1423891003388 CoenzymeA binding site [chemical binding]; other site 1423891003389 subunit interaction site [polypeptide binding]; other site 1423891003390 PHB binding site; other site 1423891003391 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1423891003392 23S rRNA interface [nucleotide binding]; other site 1423891003393 L3 interface [polypeptide binding]; other site 1423891003394 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1423891003395 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1423891003396 oligomer interface [polypeptide binding]; other site 1423891003397 putative active site [active] 1423891003398 Mn binding site [ion binding]; other site 1423891003399 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 1423891003400 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1423891003401 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1423891003402 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 1423891003403 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1423891003404 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1423891003405 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 1423891003406 SLBB domain; Region: SLBB; pfam10531 1423891003407 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1423891003408 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 1423891003409 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1423891003410 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 1423891003411 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1423891003412 DNA binding residues [nucleotide binding] 1423891003413 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1423891003414 IHF dimer interface [polypeptide binding]; other site 1423891003415 IHF - DNA interface [nucleotide binding]; other site 1423891003416 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1423891003417 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1423891003418 dimer interface [polypeptide binding]; other site 1423891003419 active site 1423891003420 CoA binding pocket [chemical binding]; other site 1423891003421 putative phosphate acyltransferase; Provisional; Region: PRK05331 1423891003422 Uncharacterized conserved protein [Function unknown]; Region: COG5452 1423891003423 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 1423891003424 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1423891003425 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; COG3808 1423891003426 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 1423891003427 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1423891003428 putative RNA binding site [nucleotide binding]; other site 1423891003429 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1423891003430 homopentamer interface [polypeptide binding]; other site 1423891003431 active site 1423891003432 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1423891003433 Lumazine binding domain; Region: Lum_binding; pfam00677 1423891003434 Lumazine binding domain; Region: Lum_binding; pfam00677 1423891003435 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1423891003436 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1423891003437 catalytic motif [active] 1423891003438 Zn binding site [ion binding]; other site 1423891003439 RibD C-terminal domain; Region: RibD_C; cl17279 1423891003440 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1423891003441 ATP cone domain; Region: ATP-cone; pfam03477 1423891003442 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1423891003443 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1423891003444 dimer interface [polypeptide binding]; other site 1423891003445 active site 1423891003446 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1423891003447 folate binding site [chemical binding]; other site 1423891003448 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 1423891003449 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1423891003450 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1423891003451 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1423891003452 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1423891003453 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1423891003454 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1423891003455 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1423891003456 substrate binding site [chemical binding]; other site 1423891003457 oxyanion hole (OAH) forming residues; other site 1423891003458 trimer interface [polypeptide binding]; other site 1423891003459 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1423891003460 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 1423891003461 dimer interface [polypeptide binding]; other site 1423891003462 allosteric magnesium binding site [ion binding]; other site 1423891003463 active site 1423891003464 aspartate-rich active site metal binding site; other site 1423891003465 Schiff base residues; other site 1423891003466 Predicted membrane protein/domain [Function unknown]; Region: COG1714 1423891003467 Putative arginyl-tRNA:protein arginylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG2935 1423891003468 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 1423891003469 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 1423891003470 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1423891003471 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1423891003472 CAP-like domain; other site 1423891003473 active site 1423891003474 primary dimer interface [polypeptide binding]; other site 1423891003475 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1423891003476 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1423891003477 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1423891003478 dimer interface [polypeptide binding]; other site 1423891003479 anticodon binding site; other site 1423891003480 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1423891003481 homodimer interface [polypeptide binding]; other site 1423891003482 motif 1; other site 1423891003483 active site 1423891003484 motif 2; other site 1423891003485 GAD domain; Region: GAD; pfam02938 1423891003486 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1423891003487 active site 1423891003488 motif 3; other site 1423891003489 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1423891003490 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1423891003491 catalytic site [active] 1423891003492 putative active site [active] 1423891003493 putative substrate binding site [chemical binding]; other site 1423891003494 HRDC domain; Region: HRDC; pfam00570 1423891003495 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1423891003496 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1423891003497 polyphosphate kinase; Provisional; Region: PRK05443 1423891003498 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1423891003499 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1423891003500 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1423891003501 putative domain interface [polypeptide binding]; other site 1423891003502 putative active site [active] 1423891003503 catalytic site [active] 1423891003504 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1423891003505 putative domain interface [polypeptide binding]; other site 1423891003506 putative active site [active] 1423891003507 catalytic site [active] 1423891003508 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391 1423891003509 salicylate hydroxylase; Provisional; Region: PRK06475 1423891003510 salicylate hydroxylase; Provisional; Region: PRK08163 1423891003511 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1423891003512 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1423891003513 Walker A/P-loop; other site 1423891003514 ATP binding site [chemical binding]; other site 1423891003515 Q-loop/lid; other site 1423891003516 ABC transporter signature motif; other site 1423891003517 Walker B; other site 1423891003518 D-loop; other site 1423891003519 H-loop/switch region; other site 1423891003520 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1423891003521 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891003522 dimer interface [polypeptide binding]; other site 1423891003523 conserved gate region; other site 1423891003524 putative PBP binding loops; other site 1423891003525 ABC-ATPase subunit interface; other site 1423891003526 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 1423891003527 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891003528 conserved gate region; other site 1423891003529 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891003530 putative PBP binding loops; other site 1423891003531 dimer interface [polypeptide binding]; other site 1423891003532 ABC-ATPase subunit interface; other site 1423891003533 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1423891003534 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1423891003535 substrate binding pocket [chemical binding]; other site 1423891003536 membrane-bound complex binding site; other site 1423891003537 hinge residues; other site 1423891003538 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1423891003539 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1423891003540 active site 1423891003541 cystathionine beta-lyase; Provisional; Region: PRK05967 1423891003542 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1423891003543 homodimer interface [polypeptide binding]; other site 1423891003544 substrate-cofactor binding pocket; other site 1423891003545 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1423891003546 catalytic residue [active] 1423891003547 Bacterial SH3 domain; Region: SH3_3; pfam08239 1423891003548 Uncharacterized protein containing a TIR (Toll-Interleukin 1-resistance) domain [Function unknown]; Region: COG4916 1423891003549 TIR domain; Region: TIR_2; pfam13676 1423891003550 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1423891003551 AAA domain; Region: AAA_22; pfam13401 1423891003552 AAA ATPase domain; Region: AAA_16; pfam13191 1423891003553 Integrase core domain; Region: rve; pfam00665 1423891003554 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1423891003555 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1423891003556 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 1423891003557 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1423891003558 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1423891003559 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1423891003560 non-specific DNA binding site [nucleotide binding]; other site 1423891003561 salt bridge; other site 1423891003562 sequence-specific DNA binding site [nucleotide binding]; other site 1423891003563 Uncharacterized conserved protein [Function unknown]; Region: COG4933 1423891003564 Archaeal adenylate kinase [Nucleotide transport and metabolism]; Region: AdkA; COG2019 1423891003565 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 1423891003566 active site 1423891003567 catalytic site [active] 1423891003568 substrate binding site [chemical binding]; other site 1423891003569 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 1423891003570 L-lactate permease; Region: Lactate_perm; cl00701 1423891003571 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1423891003572 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1423891003573 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1423891003574 putative NAD(P) binding site [chemical binding]; other site 1423891003575 putative active site [active] 1423891003576 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1423891003577 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1423891003578 NAD(P) binding site [chemical binding]; other site 1423891003579 active site 1423891003580 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1423891003581 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1423891003582 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1423891003583 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1423891003584 dimerization interface [polypeptide binding]; other site 1423891003585 putative ATP binding site [chemical binding]; other site 1423891003586 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1423891003587 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1423891003588 active site 1423891003589 substrate binding site [chemical binding]; other site 1423891003590 cosubstrate binding site; other site 1423891003591 catalytic site [active] 1423891003592 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1423891003593 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1423891003594 putative [4Fe-4S] binding site [ion binding]; other site 1423891003595 putative molybdopterin cofactor binding site [chemical binding]; other site 1423891003596 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 1423891003597 putative molybdopterin cofactor binding site; other site 1423891003598 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 1423891003599 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1423891003600 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1423891003601 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 1423891003602 putative C-terminal domain interface [polypeptide binding]; other site 1423891003603 putative GSH binding site (G-site) [chemical binding]; other site 1423891003604 putative dimer interface [polypeptide binding]; other site 1423891003605 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1423891003606 dimer interface [polypeptide binding]; other site 1423891003607 N-terminal domain interface [polypeptide binding]; other site 1423891003608 putative substrate binding pocket (H-site) [chemical binding]; other site 1423891003609 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1423891003610 short chain dehydrogenase; Provisional; Region: PRK09134 1423891003611 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 1423891003612 NADP binding site [chemical binding]; other site 1423891003613 substrate binding pocket [chemical binding]; other site 1423891003614 active site 1423891003615 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1423891003616 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1423891003617 GIY-YIG motif/motif A; other site 1423891003618 active site 1423891003619 catalytic site [active] 1423891003620 putative DNA binding site [nucleotide binding]; other site 1423891003621 metal binding site [ion binding]; metal-binding site 1423891003622 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1423891003623 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1423891003624 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1423891003625 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1423891003626 MoaE interaction surface [polypeptide binding]; other site 1423891003627 MoeB interaction surface [polypeptide binding]; other site 1423891003628 thiocarboxylated glycine; other site 1423891003629 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1423891003630 MoaE homodimer interface [polypeptide binding]; other site 1423891003631 MoaD interaction [polypeptide binding]; other site 1423891003632 active site residues [active] 1423891003633 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 1423891003634 Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187 1423891003635 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1423891003636 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 1423891003637 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1423891003638 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1423891003639 active site 1423891003640 multimer interface [polypeptide binding]; other site 1423891003641 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 1423891003642 DinB superfamily; Region: DinB_2; pfam12867 1423891003643 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1423891003644 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1423891003645 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1423891003646 Walker A/P-loop; other site 1423891003647 ATP binding site [chemical binding]; other site 1423891003648 ABC transporter signature motif; other site 1423891003649 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1423891003650 Walker B; other site 1423891003651 D-loop; other site 1423891003652 ABC transporter; Region: ABC_tran_2; pfam12848 1423891003653 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1423891003654 DNA polymerase III subunit chi; Validated; Region: PRK05728 1423891003655 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1423891003656 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1423891003657 interface (dimer of trimers) [polypeptide binding]; other site 1423891003658 Substrate-binding/catalytic site; other site 1423891003659 Zn-binding sites [ion binding]; other site 1423891003660 Predicted permeases [General function prediction only]; Region: COG0795 1423891003661 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1423891003662 Predicted permeases [General function prediction only]; Region: COG0795 1423891003663 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1423891003664 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 1423891003665 OstA-like protein; Region: OstA; cl00844 1423891003666 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1423891003667 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1423891003668 SurA N-terminal domain; Region: SurA_N; pfam09312 1423891003669 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312 1423891003670 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1423891003671 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1423891003672 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1423891003673 S-adenosylmethionine binding site [chemical binding]; other site 1423891003674 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1423891003675 Peptidase family M23; Region: Peptidase_M23; pfam01551 1423891003676 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1423891003677 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 1423891003678 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 1423891003679 active site 1423891003680 catalytic residues [active] 1423891003681 metal binding site [ion binding]; metal-binding site 1423891003682 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1423891003683 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1423891003684 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1423891003685 active site 1423891003686 HIGH motif; other site 1423891003687 nucleotide binding site [chemical binding]; other site 1423891003688 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1423891003689 KMSKS motif; other site 1423891003690 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1423891003691 Lysine efflux permease [General function prediction only]; Region: COG1279 1423891003692 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1423891003693 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 1423891003694 nudix motif; other site 1423891003695 dihydroorotase; Validated; Region: PRK09060 1423891003696 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1423891003697 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 1423891003698 active site 1423891003699 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1423891003700 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1423891003701 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1423891003702 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 1423891003703 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 1423891003704 Recombination protein O N terminal; Region: RecO_N; pfam11967 1423891003705 DNA repair protein RecO; Region: reco; TIGR00613 1423891003706 Recombination protein O C terminal; Region: RecO_C; pfam02565 1423891003707 GTPase Era; Reviewed; Region: era; PRK00089 1423891003708 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1423891003709 G1 box; other site 1423891003710 GTP/Mg2+ binding site [chemical binding]; other site 1423891003711 Switch I region; other site 1423891003712 G2 box; other site 1423891003713 Switch II region; other site 1423891003714 G3 box; other site 1423891003715 G4 box; other site 1423891003716 G5 box; other site 1423891003717 KH domain; Region: KH_2; pfam07650 1423891003718 ribonuclease III; Reviewed; Region: PRK12371 1423891003719 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1423891003720 dimerization interface [polypeptide binding]; other site 1423891003721 active site 1423891003722 metal binding site [ion binding]; metal-binding site 1423891003723 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1423891003724 dsRNA binding site [nucleotide binding]; other site 1423891003725 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1423891003726 Catalytic site [active] 1423891003727 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 1423891003728 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1423891003729 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1423891003730 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1423891003731 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1423891003732 Helix-turn-helix domain; Region: HTH_18; pfam12833 1423891003733 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1423891003734 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1423891003735 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1423891003736 putative substrate translocation pore; other site 1423891003737 coproporphyrinogen III oxidase; Provisional; Region: PRK13347 1423891003738 HemN C-terminal domain; Region: HemN_C; pfam06969 1423891003739 coproporphyrinogen III oxidase; Provisional; Region: PRK13347 1423891003740 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1423891003741 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1423891003742 ligand binding site [chemical binding]; other site 1423891003743 flexible hinge region; other site 1423891003744 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1423891003745 putative switch regulator; other site 1423891003746 non-specific DNA interactions [nucleotide binding]; other site 1423891003747 DNA binding site [nucleotide binding] 1423891003748 sequence specific DNA binding site [nucleotide binding]; other site 1423891003749 putative cAMP binding site [chemical binding]; other site 1423891003750 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1423891003751 active site 1423891003752 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1423891003753 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1423891003754 Zn2+ binding site [ion binding]; other site 1423891003755 Mg2+ binding site [ion binding]; other site 1423891003756 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1423891003757 synthetase active site [active] 1423891003758 NTP binding site [chemical binding]; other site 1423891003759 metal binding site [ion binding]; metal-binding site 1423891003760 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1423891003761 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1423891003762 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1423891003763 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1423891003764 LabA_like proteins; Region: LabA; cd10911 1423891003765 putative metal binding site [ion binding]; other site 1423891003766 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 1423891003767 Fe-S cluster binding site [ion binding]; other site 1423891003768 DNA binding site [nucleotide binding] 1423891003769 active site 1423891003770 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1423891003771 SmpB-tmRNA interface; other site 1423891003772 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1423891003773 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1423891003774 dimer interface [polypeptide binding]; other site 1423891003775 active site 1423891003776 catalytic residue [active] 1423891003777 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1423891003778 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1423891003779 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1423891003780 catalytic residue [active] 1423891003781 Uncharacterized conserved protein [Function unknown]; Region: COG3743 1423891003782 Porin subfamily; Region: Porin_2; pfam02530 1423891003783 Porin subfamily; Region: Porin_2; pfam02530 1423891003784 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1423891003785 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1423891003786 active site 1423891003787 DNA binding site [nucleotide binding] 1423891003788 Int/Topo IB signature motif; other site 1423891003789 histidinol-phosphate aminotransferase; Provisional; Region: PRK08153 1423891003790 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1423891003791 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1423891003792 homodimer interface [polypeptide binding]; other site 1423891003793 catalytic residue [active] 1423891003794 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1423891003795 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1423891003796 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4731 1423891003797 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1423891003798 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1423891003799 C-terminal domain interface [polypeptide binding]; other site 1423891003800 GSH binding site (G-site) [chemical binding]; other site 1423891003801 dimer interface [polypeptide binding]; other site 1423891003802 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 1423891003803 N-terminal domain interface [polypeptide binding]; other site 1423891003804 putative dimer interface [polypeptide binding]; other site 1423891003805 active site 1423891003806 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3021 1423891003807 putative catalytic site [active] 1423891003808 putative metal binding site [ion binding]; other site 1423891003809 putative phosphate binding site [ion binding]; other site 1423891003810 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1423891003811 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1423891003812 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 1423891003813 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1423891003814 Fe-S cluster binding site [ion binding]; other site 1423891003815 active site 1423891003816 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1423891003817 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1423891003818 putative substrate translocation pore; other site 1423891003819 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1423891003820 EamA-like transporter family; Region: EamA; pfam00892 1423891003821 aminopeptidase N; Provisional; Region: pepN; PRK14015 1423891003822 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 1423891003823 active site 1423891003824 Zn binding site [ion binding]; other site 1423891003825 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1423891003826 PAS fold; Region: PAS_3; pfam08447 1423891003827 putative active site [active] 1423891003828 heme pocket [chemical binding]; other site 1423891003829 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1423891003830 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1423891003831 dimer interface [polypeptide binding]; other site 1423891003832 phosphorylation site [posttranslational modification] 1423891003833 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1423891003834 ATP binding site [chemical binding]; other site 1423891003835 Mg2+ binding site [ion binding]; other site 1423891003836 G-X-G motif; other site 1423891003837 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 1423891003838 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298 1423891003839 O-Antigen ligase; Region: Wzy_C; pfam04932 1423891003840 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 1423891003841 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1423891003842 metal binding triad; other site 1423891003843 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1423891003844 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1423891003845 metal binding triad; other site 1423891003846 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1423891003847 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1423891003848 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1423891003849 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1423891003850 dimerization interface [polypeptide binding]; other site 1423891003851 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1423891003852 dimer interface [polypeptide binding]; other site 1423891003853 phosphorylation site [posttranslational modification] 1423891003854 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1423891003855 ATP binding site [chemical binding]; other site 1423891003856 Mg2+ binding site [ion binding]; other site 1423891003857 G-X-G motif; other site 1423891003858 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1423891003859 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1423891003860 active site 1423891003861 phosphorylation site [posttranslational modification] 1423891003862 intermolecular recognition site; other site 1423891003863 dimerization interface [polypeptide binding]; other site 1423891003864 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1423891003865 DNA binding site [nucleotide binding] 1423891003866 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1423891003867 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1423891003868 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1423891003869 protein binding site [polypeptide binding]; other site 1423891003870 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1423891003871 protein binding site [polypeptide binding]; other site 1423891003872 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 1423891003873 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 1423891003874 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 1423891003875 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 1423891003876 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 1423891003877 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 1423891003878 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1423891003879 HAMP domain; Region: HAMP; pfam00672 1423891003880 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1423891003881 ATP binding site [chemical binding]; other site 1423891003882 Mg2+ binding site [ion binding]; other site 1423891003883 G-X-G motif; other site 1423891003884 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1423891003885 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1423891003886 active site 1423891003887 phosphorylation site [posttranslational modification] 1423891003888 intermolecular recognition site; other site 1423891003889 dimerization interface [polypeptide binding]; other site 1423891003890 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1423891003891 DNA binding site [nucleotide binding] 1423891003892 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 1423891003893 Putative phage tail protein; Region: Phage-tail_3; pfam13550 1423891003894 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1423891003895 putative phage cell wall peptidase, NlpC/P60 family; Region: phage_NlpC_fam; TIGR02219 1423891003896 Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931 1423891003897 phage conserved hypothetical protein BR0599; Region: phg_TIGR02218 1423891003898 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 1423891003899 Phage-related minor tail protein [Function unknown]; Region: COG5281 1423891003900 Protein of unknown function (DUF3356); Region: DUF3356; pfam11836 1423891003901 Predicted secreted protein [Function unknown]; Region: COG5437 1423891003902 Phage-related protein [Function unknown]; Region: COG4695 1423891003903 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 1423891003904 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1423891003905 Transglycosylase; Region: Transgly; cl17702 1423891003906 Predicted integral membrane protein [Function unknown]; Region: COG5436 1423891003907 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1423891003908 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 1423891003909 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1423891003910 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330 1423891003911 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 1423891003912 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1423891003913 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1423891003914 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1423891003915 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1423891003916 putative active site [active] 1423891003917 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1423891003918 heme pocket [chemical binding]; other site 1423891003919 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1423891003920 dimer interface [polypeptide binding]; other site 1423891003921 phosphorylation site [posttranslational modification] 1423891003922 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1423891003923 ATP binding site [chemical binding]; other site 1423891003924 Mg2+ binding site [ion binding]; other site 1423891003925 G-X-G motif; other site 1423891003926 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 1423891003927 amidase; Validated; Region: PRK05962 1423891003928 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1423891003929 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1423891003930 DnaA box-binding interface [nucleotide binding]; other site 1423891003931 Predicted transcriptional regulator [Transcription]; Region: COG4957 1423891003932 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1423891003933 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1423891003934 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1423891003935 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1423891003936 motif II; other site 1423891003937 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1423891003938 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1423891003939 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1423891003940 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1423891003941 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1423891003942 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1423891003943 putative substrate translocation pore; other site 1423891003944 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1423891003945 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1423891003946 DNA-binding site [nucleotide binding]; DNA binding site 1423891003947 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1423891003948 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1423891003949 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 1423891003950 Cl binding site [ion binding]; other site 1423891003951 oligomer interface [polypeptide binding]; other site 1423891003952 putative addiction module antidote; Region: doc_partner; TIGR02609 1423891003953 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 1423891003954 transcription elongation factor regulatory protein; Validated; Region: PRK06342 1423891003955 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1423891003956 L-asparaginase II [Amino acid transport and metabolism]; Region: AnsA; COG4448 1423891003957 transcriptional regulator BetI; Validated; Region: PRK00767 1423891003958 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1423891003959 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1423891003960 choline dehydrogenase; Validated; Region: PRK02106 1423891003961 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1423891003962 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 1423891003963 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 1423891003964 tetrameric interface [polypeptide binding]; other site 1423891003965 NAD binding site [chemical binding]; other site 1423891003966 catalytic residues [active] 1423891003967 Helix-turn-helix domain; Region: HTH_18; pfam12833 1423891003968 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1423891003969 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1423891003970 DNA binding site [nucleotide binding] 1423891003971 domain linker motif; other site 1423891003972 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 1423891003973 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1423891003974 putative ligand binding site [chemical binding]; other site 1423891003975 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1423891003976 N- and C-terminal domain interface [polypeptide binding]; other site 1423891003977 D-xylulose kinase; Region: XylB; TIGR01312 1423891003978 active site 1423891003979 MgATP binding site [chemical binding]; other site 1423891003980 catalytic site [active] 1423891003981 metal binding site [ion binding]; metal-binding site 1423891003982 xylulose binding site [chemical binding]; other site 1423891003983 homodimer interface [polypeptide binding]; other site 1423891003984 xylose isomerase; Provisional; Region: PRK05474 1423891003985 xylose isomerase; Region: xylose_isom_A; TIGR02630 1423891003986 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1423891003987 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1423891003988 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1423891003989 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1423891003990 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1423891003991 Metal-binding active site; metal-binding site 1423891003992 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1423891003993 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1423891003994 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_3; cd06311 1423891003995 putative ligand binding site [chemical binding]; other site 1423891003996 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1423891003997 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1423891003998 TM-ABC transporter signature motif; other site 1423891003999 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1423891004000 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1423891004001 Walker A/P-loop; other site 1423891004002 ATP binding site [chemical binding]; other site 1423891004003 Q-loop/lid; other site 1423891004004 ABC transporter signature motif; other site 1423891004005 Walker B; other site 1423891004006 D-loop; other site 1423891004007 H-loop/switch region; other site 1423891004008 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1423891004009 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1423891004010 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 1423891004011 putative ADP-binding pocket [chemical binding]; other site 1423891004012 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 1423891004013 dimerization interface [polypeptide binding]; other site 1423891004014 putative active cleft [active] 1423891004015 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1423891004016 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1423891004017 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1423891004018 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1423891004019 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 1423891004020 active site 1423891004021 metal binding site [ion binding]; metal-binding site 1423891004022 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1423891004023 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 1423891004024 Integrase core domain; Region: rve; pfam00665 1423891004025 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1423891004026 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1423891004027 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1423891004028 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1423891004029 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1423891004030 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 1423891004031 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1423891004032 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1423891004033 Integrase core domain; Region: rve; pfam00665 1423891004034 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1423891004035 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1423891004036 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1423891004037 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1423891004038 NADP-binding site; other site 1423891004039 homotetramer interface [polypeptide binding]; other site 1423891004040 substrate binding site [chemical binding]; other site 1423891004041 homodimer interface [polypeptide binding]; other site 1423891004042 active site 1423891004043 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1423891004044 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1423891004045 inhibitor-cofactor binding pocket; inhibition site 1423891004046 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1423891004047 catalytic residue [active] 1423891004048 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1423891004049 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1423891004050 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1423891004051 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1423891004052 Walker A/P-loop; other site 1423891004053 ATP binding site [chemical binding]; other site 1423891004054 Q-loop/lid; other site 1423891004055 ABC transporter signature motif; other site 1423891004056 Walker B; other site 1423891004057 D-loop; other site 1423891004058 H-loop/switch region; other site 1423891004059 HTH-like domain; Region: HTH_21; pfam13276 1423891004060 Integrase core domain; Region: rve; pfam00665 1423891004061 Integrase core domain; Region: rve_3; pfam13683 1423891004062 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1423891004063 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1423891004064 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1423891004065 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 1423891004066 Mg++ binding site [ion binding]; other site 1423891004067 putative catalytic motif [active] 1423891004068 putative substrate binding site [chemical binding]; other site 1423891004069 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1423891004070 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1423891004071 NAD(P) binding site [chemical binding]; other site 1423891004072 homodimer interface [polypeptide binding]; other site 1423891004073 substrate binding site [chemical binding]; other site 1423891004074 active site 1423891004075 Protein of unknown function (DUF2793); Region: DUF2793; pfam10983 1423891004076 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1423891004077 active site 1423891004078 homotetramer interface [polypeptide binding]; other site 1423891004079 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 1423891004080 ureidoglycolate hydrolase; Provisional; Region: PRK03606 1423891004081 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1423891004082 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1423891004083 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1423891004084 Putative catalytic NodB homology domain of uncharacterized BH0857 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH0857_like; cd10955 1423891004085 NodB motif; other site 1423891004086 putative active site [active] 1423891004087 putative catalytic site [active] 1423891004088 pyruvate phosphate dikinase; Provisional; Region: PRK09279 1423891004089 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1423891004090 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1423891004091 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1423891004092 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1423891004093 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1423891004094 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1423891004095 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1423891004096 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1423891004097 Walker A/P-loop; other site 1423891004098 ATP binding site [chemical binding]; other site 1423891004099 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1423891004100 ABC transporter signature motif; other site 1423891004101 Walker B; other site 1423891004102 D-loop; other site 1423891004103 H-loop/switch region; other site 1423891004104 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1423891004105 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1423891004106 catalytic residues [active] 1423891004107 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1423891004108 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1423891004109 minor groove reading motif; other site 1423891004110 helix-hairpin-helix signature motif; other site 1423891004111 substrate binding pocket [chemical binding]; other site 1423891004112 active site 1423891004113 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1423891004114 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1423891004115 DNA binding and oxoG recognition site [nucleotide binding] 1423891004116 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1423891004117 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1423891004118 motif II; other site 1423891004119 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1423891004120 DNA methylase; Region: N6_N4_Mtase; pfam01555 1423891004121 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1423891004122 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1423891004123 Cl- selectivity filter; other site 1423891004124 Cl- binding residues [ion binding]; other site 1423891004125 pore gating glutamate residue; other site 1423891004126 dimer interface [polypeptide binding]; other site 1423891004127 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1423891004128 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1423891004129 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1423891004130 active site 1423891004131 motif I; other site 1423891004132 motif II; other site 1423891004133 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1423891004134 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1423891004135 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1423891004136 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1423891004137 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1423891004138 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1423891004139 catalytic residue [active] 1423891004140 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1423891004141 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1423891004142 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1423891004143 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1423891004144 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1423891004145 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 1423891004146 PAS fold; Region: PAS_3; pfam08447 1423891004147 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1423891004148 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1423891004149 metal binding site [ion binding]; metal-binding site 1423891004150 active site 1423891004151 I-site; other site 1423891004152 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1423891004153 hypothetical protein; Validated; Region: PRK00228 1423891004154 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 1423891004155 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 1423891004156 catalytic triad [active] 1423891004157 dimer interface [polypeptide binding]; other site 1423891004158 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1423891004159 RNA/DNA hybrid binding site [nucleotide binding]; other site 1423891004160 active site 1423891004161 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1423891004162 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 1423891004163 putative active site [active] 1423891004164 putative substrate binding site [chemical binding]; other site 1423891004165 ATP binding site [chemical binding]; other site 1423891004166 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1423891004167 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1423891004168 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1423891004169 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349 1423891004170 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 1423891004171 Subunit III/VIIa interface [polypeptide binding]; other site 1423891004172 Phospholipid binding site [chemical binding]; other site 1423891004173 Subunit I/III interface [polypeptide binding]; other site 1423891004174 Subunit III/VIb interface [polypeptide binding]; other site 1423891004175 Subunit III/VIa interface; other site 1423891004176 Subunit III/Vb interface [polypeptide binding]; other site 1423891004177 Cytochrome oxidase assembly factor [Posttranslational modification, protein turnover, chaperones]; Region: COX11; COG3175 1423891004178 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1423891004179 UbiA prenyltransferase family; Region: UbiA; pfam01040 1423891004180 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1423891004181 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 1423891004182 Subunit I/III interface [polypeptide binding]; other site 1423891004183 D-pathway; other site 1423891004184 Subunit I/VIIc interface [polypeptide binding]; other site 1423891004185 Subunit I/IV interface [polypeptide binding]; other site 1423891004186 Subunit I/II interface [polypeptide binding]; other site 1423891004187 Low-spin heme (heme a) binding site [chemical binding]; other site 1423891004188 Subunit I/VIIa interface [polypeptide binding]; other site 1423891004189 Subunit I/VIa interface [polypeptide binding]; other site 1423891004190 Dimer interface; other site 1423891004191 Putative water exit pathway; other site 1423891004192 Binuclear center (heme a3/CuB) [ion binding]; other site 1423891004193 K-pathway; other site 1423891004194 Subunit I/Vb interface [polypeptide binding]; other site 1423891004195 Putative proton exit pathway; other site 1423891004196 Subunit I/VIb interface; other site 1423891004197 Subunit I/VIc interface [polypeptide binding]; other site 1423891004198 Electron transfer pathway; other site 1423891004199 Subunit I/VIIIb interface [polypeptide binding]; other site 1423891004200 Subunit I/VIIb interface [polypeptide binding]; other site 1423891004201 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1423891004202 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1423891004203 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1423891004204 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 1423891004205 protease TldD; Provisional; Region: tldD; PRK10735 1423891004206 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1423891004207 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1423891004208 catalytic site [active] 1423891004209 G-X2-G-X-G-K; other site 1423891004210 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 1423891004211 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1423891004212 dimerization interface [polypeptide binding]; other site 1423891004213 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1423891004214 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1423891004215 dimer interface [polypeptide binding]; other site 1423891004216 active site 1423891004217 acyl carrier protein; Provisional; Region: acpP; PRK00982 1423891004218 3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936 1423891004219 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1423891004220 NAD(P) binding site [chemical binding]; other site 1423891004221 homotetramer interface [polypeptide binding]; other site 1423891004222 homodimer interface [polypeptide binding]; other site 1423891004223 active site 1423891004224 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1423891004225 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1423891004226 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1423891004227 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1423891004228 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1423891004229 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1423891004230 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1423891004231 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1423891004232 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1423891004233 S-adenosylmethionine binding site [chemical binding]; other site 1423891004234 replicative DNA helicase; Provisional; Region: PRK09165 1423891004235 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1423891004236 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1423891004237 Walker A motif; other site 1423891004238 ATP binding site [chemical binding]; other site 1423891004239 Walker B motif; other site 1423891004240 DNA binding loops [nucleotide binding] 1423891004241 DNA repair protein RadA; Provisional; Region: PRK11823 1423891004242 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1423891004243 Walker A motif/ATP binding site; other site 1423891004244 ATP binding site [chemical binding]; other site 1423891004245 Walker B motif; other site 1423891004246 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1423891004247 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1423891004248 Colicin V production protein; Region: Colicin_V; pfam02674 1423891004249 amidophosphoribosyltransferase; Provisional; Region: PRK09123 1423891004250 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1423891004251 active site 1423891004252 tetramer interface [polypeptide binding]; other site 1423891004253 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1423891004254 active site 1423891004255 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 1423891004256 classical (c) SDRs; Region: SDR_c; cd05233 1423891004257 NAD(P) binding site [chemical binding]; other site 1423891004258 active site 1423891004259 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1423891004260 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1423891004261 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 1423891004262 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1423891004263 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 1423891004264 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 1423891004265 Walker A/P-loop; other site 1423891004266 ATP binding site [chemical binding]; other site 1423891004267 Q-loop/lid; other site 1423891004268 ABC transporter signature motif; other site 1423891004269 Walker B; other site 1423891004270 D-loop; other site 1423891004271 H-loop/switch region; other site 1423891004272 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 1423891004273 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1423891004274 Predicted periplasmic protein [General function prediction only]; Region: COG3895 1423891004275 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1423891004276 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1423891004277 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1423891004278 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1423891004279 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1423891004280 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1423891004281 RNA binding surface [nucleotide binding]; other site 1423891004282 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1423891004283 S-adenosylmethionine binding site [chemical binding]; other site 1423891004284 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1423891004285 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1423891004286 TPP-binding site; other site 1423891004287 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1423891004288 PYR/PP interface [polypeptide binding]; other site 1423891004289 dimer interface [polypeptide binding]; other site 1423891004290 TPP binding site [chemical binding]; other site 1423891004291 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1423891004292 Pirin-related protein [General function prediction only]; Region: COG1741 1423891004293 Pirin; Region: Pirin; pfam02678 1423891004294 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1423891004295 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3753 1423891004296 Predicted membrane protein [Function unknown]; Region: COG2261 1423891004297 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1423891004298 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1423891004299 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1423891004300 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1423891004301 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 1423891004302 putative active site [active] 1423891004303 Zn binding site [ion binding]; other site 1423891004304 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09314 1423891004305 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1423891004306 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 1423891004307 dimerization interface [polypeptide binding]; other site 1423891004308 active site 1423891004309 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1423891004310 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1423891004311 Tetramer interface [polypeptide binding]; other site 1423891004312 active site 1423891004313 FMN-binding site [chemical binding]; other site 1423891004314 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 1423891004315 putative acyl-acceptor binding pocket; other site 1423891004316 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1423891004317 DNA-binding site [nucleotide binding]; DNA binding site 1423891004318 RNA-binding motif; other site 1423891004319 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1423891004320 catalytic core [active] 1423891004321 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 1423891004322 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1423891004323 NAD binding site [chemical binding]; other site 1423891004324 homotetramer interface [polypeptide binding]; other site 1423891004325 homodimer interface [polypeptide binding]; other site 1423891004326 substrate binding site [chemical binding]; other site 1423891004327 active site 1423891004328 chaperone protein DnaJ; Provisional; Region: PRK14299 1423891004329 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1423891004330 HSP70 interaction site [polypeptide binding]; other site 1423891004331 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1423891004332 dimer interface [polypeptide binding]; other site 1423891004333 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1423891004334 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1423891004335 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1423891004336 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878 1423891004337 UbiA prenyltransferase family; Region: UbiA; pfam01040 1423891004338 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1423891004339 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1423891004340 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1423891004341 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1423891004342 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1423891004343 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1423891004344 metal binding site [ion binding]; metal-binding site 1423891004345 active site 1423891004346 I-site; other site 1423891004347 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1423891004348 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1423891004349 active site 1423891004350 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1423891004351 enoyl-CoA hydratase; Provisional; Region: PRK06688 1423891004352 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1423891004353 substrate binding site [chemical binding]; other site 1423891004354 oxyanion hole (OAH) forming residues; other site 1423891004355 trimer interface [polypeptide binding]; other site 1423891004356 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1423891004357 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1423891004358 FAD binding domain; Region: FAD_binding_4; pfam01565 1423891004359 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1423891004360 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1423891004361 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1423891004362 DALR anticodon binding domain; Region: DALR_1; pfam05746 1423891004363 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1423891004364 dimer interface [polypeptide binding]; other site 1423891004365 motif 1; other site 1423891004366 active site 1423891004367 motif 2; other site 1423891004368 motif 3; other site 1423891004369 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1423891004370 binding surface 1423891004371 TPR motif; other site 1423891004372 TPR repeat; Region: TPR_11; pfam13414 1423891004373 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1423891004374 binding surface 1423891004375 TPR motif; other site 1423891004376 TPR repeat; Region: TPR_11; pfam13414 1423891004377 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1423891004378 binding surface 1423891004379 TPR motif; other site 1423891004380 TPR repeat; Region: TPR_11; pfam13414 1423891004381 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1423891004382 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1423891004383 substrate binding pocket [chemical binding]; other site 1423891004384 chain length determination region; other site 1423891004385 substrate-Mg2+ binding site; other site 1423891004386 catalytic residues [active] 1423891004387 aspartate-rich region 1; other site 1423891004388 active site lid residues [active] 1423891004389 aspartate-rich region 2; other site 1423891004390 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1423891004391 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1423891004392 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 1423891004393 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1423891004394 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1423891004395 tandem repeat interface [polypeptide binding]; other site 1423891004396 oligomer interface [polypeptide binding]; other site 1423891004397 active site residues [active] 1423891004398 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 1423891004399 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1423891004400 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1423891004401 active site 1423891004402 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1423891004403 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1423891004404 FeS/SAM binding site; other site 1423891004405 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1423891004406 RNA/DNA hybrid binding site [nucleotide binding]; other site 1423891004407 active site 1423891004408 F0F1 ATP synthase subunit B; Validated; Region: PRK09173 1423891004409 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1423891004410 F0F1 ATP synthase subunit B'; Validated; Region: PRK09174 1423891004411 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1423891004412 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 1423891004413 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1423891004414 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1423891004415 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5336 1423891004416 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 1423891004417 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1423891004418 GTP-binding protein Der; Reviewed; Region: PRK00093 1423891004419 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1423891004420 G1 box; other site 1423891004421 GTP/Mg2+ binding site [chemical binding]; other site 1423891004422 Switch I region; other site 1423891004423 G2 box; other site 1423891004424 Switch II region; other site 1423891004425 G3 box; other site 1423891004426 G4 box; other site 1423891004427 G5 box; other site 1423891004428 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1423891004429 G1 box; other site 1423891004430 GTP/Mg2+ binding site [chemical binding]; other site 1423891004431 Switch I region; other site 1423891004432 G2 box; other site 1423891004433 G3 box; other site 1423891004434 Switch II region; other site 1423891004435 G4 box; other site 1423891004436 G5 box; other site 1423891004437 Putative catalytic domain of uncharacterized bacterial hypothetical proteins similar to insect chitin deacetylase-like proteins; Region: CE4_CDA_like_3; cd10976 1423891004438 NodB motif; other site 1423891004439 putative active site [active] 1423891004440 putative catalytic site [active] 1423891004441 microcin B17 transporter; Reviewed; Region: PRK11098 1423891004442 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1423891004443 putative substrate translocation pore; other site 1423891004444 D-galactonate transporter; Region: 2A0114; TIGR00893 1423891004445 Predicted membrane protein [Function unknown]; Region: COG4129 1423891004446 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1423891004447 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 1423891004448 ArsC family; Region: ArsC; pfam03960 1423891004449 putative catalytic residues [active] 1423891004450 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 1423891004451 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1423891004452 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1423891004453 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1423891004454 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1423891004455 DNA binding site [nucleotide binding] 1423891004456 active site 1423891004457 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1423891004458 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 1423891004459 NAD(P) binding site [chemical binding]; other site 1423891004460 catalytic residues [active] 1423891004461 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 1423891004462 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1423891004463 catalytic residues [active] 1423891004464 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1423891004465 metal binding site 2 [ion binding]; metal-binding site 1423891004466 putative DNA binding helix; other site 1423891004467 metal binding site 1 [ion binding]; metal-binding site 1423891004468 dimer interface [polypeptide binding]; other site 1423891004469 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 1423891004470 Low-spin heme binding site [chemical binding]; other site 1423891004471 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1423891004472 Putative water exit pathway; other site 1423891004473 Binuclear center (active site) [active] 1423891004474 Putative proton exit pathway; other site 1423891004475 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 1423891004476 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 1423891004477 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 1423891004478 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 1423891004479 Cytochrome c; Region: Cytochrom_C; pfam00034 1423891004480 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1423891004481 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 1423891004482 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1423891004483 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 1423891004484 Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456 1423891004485 FixH; Region: FixH; pfam05751 1423891004486 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1423891004487 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1423891004488 metal-binding site [ion binding] 1423891004489 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 1423891004490 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 1423891004491 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 1423891004492 MOFRL family; Region: MOFRL; pfam05161 1423891004493 guanine deaminase; Provisional; Region: PRK09228 1423891004494 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 1423891004495 active site 1423891004496 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1423891004497 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1423891004498 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1423891004499 putative effector binding pocket; other site 1423891004500 dimerization interface [polypeptide binding]; other site 1423891004501 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1423891004502 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 1423891004503 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1423891004504 Xanthine dehydrogenase, molybdopterin-binding subunit B [Nucleotide transport and metabolism]; Region: XdhB; COG4631 1423891004505 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1423891004506 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1423891004507 Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [Nucleotide transport and metabolism]; Region: XdhA; COG4630 1423891004508 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1423891004509 catalytic loop [active] 1423891004510 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1423891004511 iron binding site [ion binding]; other site 1423891004512 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1423891004513 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1423891004514 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 1423891004515 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 1423891004516 active site 1423891004517 catalytic site [active] 1423891004518 tetramer interface [polypeptide binding]; other site 1423891004519 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 1423891004520 hypothetical protein; Provisional; Region: PRK11171 1423891004521 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 1423891004522 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1423891004523 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1423891004524 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1423891004525 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 1423891004526 DctM-like transporters; Region: DctM; pfam06808 1423891004527 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 1423891004528 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1423891004529 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1423891004530 active site 1423891004531 phosphorylation site [posttranslational modification] 1423891004532 intermolecular recognition site; other site 1423891004533 dimerization interface [polypeptide binding]; other site 1423891004534 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1423891004535 DNA binding residues [nucleotide binding] 1423891004536 dimerization interface [polypeptide binding]; other site 1423891004537 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 1423891004538 Cache domain; Region: Cache_2; pfam08269 1423891004539 Histidine kinase; Region: HisKA_3; pfam07730 1423891004540 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1423891004541 ATP binding site [chemical binding]; other site 1423891004542 Mg2+ binding site [ion binding]; other site 1423891004543 G-X-G motif; other site 1423891004544 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1423891004545 multidrug efflux protein; Reviewed; Region: PRK01766 1423891004546 cation binding site [ion binding]; other site 1423891004547 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 1423891004548 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1423891004549 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 1423891004550 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 1423891004551 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 1423891004552 dimer interface [polypeptide binding]; other site 1423891004553 active site 1423891004554 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1423891004555 catalytic residues [active] 1423891004556 substrate binding site [chemical binding]; other site 1423891004557 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1423891004558 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1423891004559 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1423891004560 FAD binding pocket [chemical binding]; other site 1423891004561 FAD binding motif [chemical binding]; other site 1423891004562 phosphate binding motif [ion binding]; other site 1423891004563 beta-alpha-beta structure motif; other site 1423891004564 NAD binding pocket [chemical binding]; other site 1423891004565 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1423891004566 active site 1423891004567 oligomerization interface [polypeptide binding]; other site 1423891004568 metal binding site [ion binding]; metal-binding site 1423891004569 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1423891004570 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1423891004571 active site 1423891004572 ATP-binding site [chemical binding]; other site 1423891004573 pantoate-binding site; other site 1423891004574 HXXH motif; other site 1423891004575 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 1423891004576 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1423891004577 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 1423891004578 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1423891004579 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1423891004580 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1423891004581 dimerization interface [polypeptide binding]; other site 1423891004582 Glycosyltransferase family 29 (sialyltransferase); Region: Glyco_transf_29; pfam00777 1423891004583 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 1423891004584 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1423891004585 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1423891004586 putative active site [active] 1423891004587 putative metal binding site [ion binding]; other site 1423891004588 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1423891004589 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1423891004590 substrate-cofactor binding pocket; other site 1423891004591 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1423891004592 catalytic residue [active] 1423891004593 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1423891004594 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 1423891004595 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 1423891004596 Na binding site [ion binding]; other site 1423891004597 PAS fold; Region: PAS_7; pfam12860 1423891004598 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1423891004599 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1423891004600 dimer interface [polypeptide binding]; other site 1423891004601 phosphorylation site [posttranslational modification] 1423891004602 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1423891004603 ATP binding site [chemical binding]; other site 1423891004604 Mg2+ binding site [ion binding]; other site 1423891004605 G-X-G motif; other site 1423891004606 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1423891004607 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1423891004608 active site 1423891004609 phosphorylation site [posttranslational modification] 1423891004610 intermolecular recognition site; other site 1423891004611 dimerization interface [polypeptide binding]; other site 1423891004612 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1423891004613 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1423891004614 intermolecular recognition site; other site 1423891004615 active site 1423891004616 dimerization interface [polypeptide binding]; other site 1423891004617 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1423891004618 DNA binding residues [nucleotide binding] 1423891004619 dimerization interface [polypeptide binding]; other site 1423891004620 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1423891004621 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1423891004622 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 1423891004623 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1423891004624 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1423891004625 quinone interaction residues [chemical binding]; other site 1423891004626 active site 1423891004627 catalytic residues [active] 1423891004628 FMN binding site [chemical binding]; other site 1423891004629 substrate binding site [chemical binding]; other site 1423891004630 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1423891004631 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 1423891004632 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1423891004633 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1423891004634 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1423891004635 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1423891004636 conserved cys residue [active] 1423891004637 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 1423891004638 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 1423891004639 trimer interface [polypeptide binding]; other site 1423891004640 active site 1423891004641 Deoxycytidine deaminase [Nucleotide transport and metabolism]; Region: Dcd; COG0717 1423891004642 trimer interface [polypeptide binding]; other site 1423891004643 active site 1423891004644 O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504 1423891004645 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1423891004646 homodimer interface [polypeptide binding]; other site 1423891004647 substrate-cofactor binding pocket; other site 1423891004648 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1423891004649 catalytic residue [active] 1423891004650 Protein of unknown function (DUF525); Region: DUF525; cl01119 1423891004651 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 1423891004652 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1423891004653 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1423891004654 dimerization interface [polypeptide binding]; other site 1423891004655 domain crossover interface; other site 1423891004656 redox-dependent activation switch; other site 1423891004657 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1423891004658 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1423891004659 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1423891004660 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 1423891004661 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1423891004662 inhibitor-cofactor binding pocket; inhibition site 1423891004663 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1423891004664 catalytic residue [active] 1423891004665 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1423891004666 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1423891004667 dimer interface [polypeptide binding]; other site 1423891004668 phosphorylation site [posttranslational modification] 1423891004669 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1423891004670 ATP binding site [chemical binding]; other site 1423891004671 Mg2+ binding site [ion binding]; other site 1423891004672 G-X-G motif; other site 1423891004673 CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427 1423891004674 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1423891004675 DXD motif; other site 1423891004676 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1423891004677 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1423891004678 substrate binding pocket [chemical binding]; other site 1423891004679 membrane-bound complex binding site; other site 1423891004680 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1423891004681 Protein export membrane protein; Region: SecD_SecF; cl14618 1423891004682 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1423891004683 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1423891004684 HlyD family secretion protein; Region: HlyD_3; pfam13437 1423891004685 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 1423891004686 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1423891004687 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1423891004688 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 1423891004689 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1423891004690 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1423891004691 acyl-activating enzyme (AAE) consensus motif; other site 1423891004692 putative AMP binding site [chemical binding]; other site 1423891004693 putative active site [active] 1423891004694 putative CoA binding site [chemical binding]; other site 1423891004695 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 1423891004696 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1423891004697 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1423891004698 motif II; other site 1423891004699 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1423891004700 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1423891004701 Zn binding site [ion binding]; other site 1423891004702 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1423891004703 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1423891004704 active site 1423891004705 dimer interface [polypeptide binding]; other site 1423891004706 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1423891004707 dimer interface [polypeptide binding]; other site 1423891004708 active site 1423891004709 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 1423891004710 putative hydrophobic ligand binding site [chemical binding]; other site 1423891004711 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 1423891004712 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1423891004713 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1423891004714 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 1423891004715 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 1423891004716 homodimer interface [polypeptide binding]; other site 1423891004717 active site 1423891004718 FMN binding site [chemical binding]; other site 1423891004719 substrate binding site [chemical binding]; other site 1423891004720 4Fe-4S binding domain; Region: Fer4; cl02805 1423891004721 4Fe-4S binding domain; Region: Fer4; pfam00037 1423891004722 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1423891004723 nudix motif; other site 1423891004724 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1423891004725 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1423891004726 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1423891004727 allantoate amidohydrolase; Reviewed; Region: PRK12893 1423891004728 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1423891004729 active site 1423891004730 metal binding site [ion binding]; metal-binding site 1423891004731 dimer interface [polypeptide binding]; other site 1423891004732 phenylhydantoinase; Validated; Region: PRK08323 1423891004733 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 1423891004734 tetramer interface [polypeptide binding]; other site 1423891004735 active site 1423891004736 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1423891004737 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1423891004738 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1423891004739 HlyD family secretion protein; Region: HlyD_3; pfam13437 1423891004740 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1423891004741 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1423891004742 ATP binding site [chemical binding]; other site 1423891004743 Mg2+ binding site [ion binding]; other site 1423891004744 G-X-G motif; other site 1423891004745 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1423891004746 Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371 1423891004747 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1423891004748 dimer interface [polypeptide binding]; other site 1423891004749 catalytic residues [active] 1423891004750 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1423891004751 gamma-beta subunit interface [polypeptide binding]; other site 1423891004752 alpha-beta subunit interface [polypeptide binding]; other site 1423891004753 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1423891004754 alpha-gamma subunit interface [polypeptide binding]; other site 1423891004755 beta-gamma subunit interface [polypeptide binding]; other site 1423891004756 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 1423891004757 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1423891004758 non-specific DNA binding site [nucleotide binding]; other site 1423891004759 salt bridge; other site 1423891004760 sequence-specific DNA binding site [nucleotide binding]; other site 1423891004761 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1423891004762 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1423891004763 catalytic nucleophile [active] 1423891004764 Prophage antirepressor [Transcription]; Region: COG3617 1423891004765 BRO family, N-terminal domain; Region: Bro-N; smart01040 1423891004766 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1423891004767 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1423891004768 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1423891004769 active site 1423891004770 DNA binding site [nucleotide binding] 1423891004771 Int/Topo IB signature motif; other site 1423891004772 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1423891004773 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1423891004774 hinge; other site 1423891004775 active site 1423891004776 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1423891004777 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1423891004778 NAD binding site [chemical binding]; other site 1423891004779 dimerization interface [polypeptide binding]; other site 1423891004780 product binding site; other site 1423891004781 substrate binding site [chemical binding]; other site 1423891004782 zinc binding site [ion binding]; other site 1423891004783 catalytic residues [active] 1423891004784 hypothetical protein; Provisional; Region: PRK02853 1423891004785 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1423891004786 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1423891004787 active site 1423891004788 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1423891004789 rRNA binding site [nucleotide binding]; other site 1423891004790 predicted 30S ribosome binding site; other site 1423891004791 Maf-like protein; Region: Maf; pfam02545 1423891004792 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1423891004793 active site 1423891004794 dimer interface [polypeptide binding]; other site 1423891004795 zinc-binding protein; Provisional; Region: PRK01343 1423891004796 TIR domain; Region: TIR_2; pfam13676 1423891004797 GcrA cell cycle regulator; Region: GcrA; cl11564 1423891004798 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1423891004799 non-specific DNA binding site [nucleotide binding]; other site 1423891004800 salt bridge; other site 1423891004801 sequence-specific DNA binding site [nucleotide binding]; other site 1423891004802 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 1423891004803 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1423891004804 Toprim domain; Region: Toprim_3; pfam13362 1423891004805 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 1423891004806 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1423891004807 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1423891004808 active site 1423891004809 Int/Topo IB signature motif; other site 1423891004810 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1423891004811 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 1423891004812 putative active site pocket [active] 1423891004813 metal binding site [ion binding]; metal-binding site 1423891004814 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1423891004815 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1423891004816 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1423891004817 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 1423891004818 NAD binding site [chemical binding]; other site 1423891004819 homotetramer interface [polypeptide binding]; other site 1423891004820 homodimer interface [polypeptide binding]; other site 1423891004821 active site 1423891004822 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1423891004823 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1423891004824 Uncharacterized conserved protein [Function unknown]; Region: COG3254 1423891004825 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1423891004826 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1423891004827 active site pocket [active] 1423891004828 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1423891004829 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1423891004830 Walker A/P-loop; other site 1423891004831 ATP binding site [chemical binding]; other site 1423891004832 Q-loop/lid; other site 1423891004833 ABC transporter signature motif; other site 1423891004834 Walker B; other site 1423891004835 D-loop; other site 1423891004836 H-loop/switch region; other site 1423891004837 TOBE domain; Region: TOBE_2; pfam08402 1423891004838 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1423891004839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891004840 dimer interface [polypeptide binding]; other site 1423891004841 conserved gate region; other site 1423891004842 putative PBP binding loops; other site 1423891004843 ABC-ATPase subunit interface; other site 1423891004844 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891004845 dimer interface [polypeptide binding]; other site 1423891004846 conserved gate region; other site 1423891004847 putative PBP binding loops; other site 1423891004848 ABC-ATPase subunit interface; other site 1423891004849 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1423891004850 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1423891004851 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1423891004852 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1423891004853 putative DNA binding site [nucleotide binding]; other site 1423891004854 putative Zn2+ binding site [ion binding]; other site 1423891004855 Bacterial transcriptional regulator; Region: IclR; pfam01614 1423891004856 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1423891004857 Amidohydrolase; Region: Amidohydro_2; pfam04909 1423891004858 active site 1423891004859 Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583 1423891004860 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 1423891004861 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1423891004862 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1423891004863 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 1423891004864 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 1423891004865 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1423891004866 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1423891004867 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1423891004868 NAD(P) binding site [chemical binding]; other site 1423891004869 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1423891004870 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891004871 dimer interface [polypeptide binding]; other site 1423891004872 conserved gate region; other site 1423891004873 ABC-ATPase subunit interface; other site 1423891004874 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1423891004875 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1423891004876 Walker A/P-loop; other site 1423891004877 ATP binding site [chemical binding]; other site 1423891004878 Q-loop/lid; other site 1423891004879 ABC transporter signature motif; other site 1423891004880 Walker B; other site 1423891004881 D-loop; other site 1423891004882 H-loop/switch region; other site 1423891004883 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1423891004884 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891004885 dimer interface [polypeptide binding]; other site 1423891004886 conserved gate region; other site 1423891004887 putative PBP binding loops; other site 1423891004888 ABC-ATPase subunit interface; other site 1423891004889 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1423891004890 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1423891004891 DNA binding residues [nucleotide binding] 1423891004892 dimer interface [polypeptide binding]; other site 1423891004893 copper binding site [ion binding]; other site 1423891004894 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1423891004895 metal-binding site [ion binding] 1423891004896 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1423891004897 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1423891004898 metal-binding site [ion binding] 1423891004899 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1423891004900 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1423891004901 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1423891004902 putative active site [active] 1423891004903 heme pocket [chemical binding]; other site 1423891004904 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1423891004905 putative active site [active] 1423891004906 heme pocket [chemical binding]; other site 1423891004907 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1423891004908 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1423891004909 metal binding site [ion binding]; metal-binding site 1423891004910 active site 1423891004911 I-site; other site 1423891004912 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1423891004913 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1423891004914 dimer interface [polypeptide binding]; other site 1423891004915 substrate binding site [chemical binding]; other site 1423891004916 ATP binding site [chemical binding]; other site 1423891004917 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1423891004918 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1423891004919 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1423891004920 thiS-thiF/thiG interaction site; other site 1423891004921 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1423891004922 ThiS interaction site; other site 1423891004923 putative active site [active] 1423891004924 tetramer interface [polypeptide binding]; other site 1423891004925 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1423891004926 active site 1423891004927 thiamine phosphate binding site [chemical binding]; other site 1423891004928 pyrophosphate binding site [ion binding]; other site 1423891004929 NMT1/THI5 like; Region: NMT1; pfam09084 1423891004930 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1423891004931 Putative transcription activator [Transcription]; Region: TenA; COG0819 1423891004932 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1423891004933 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891004934 dimer interface [polypeptide binding]; other site 1423891004935 conserved gate region; other site 1423891004936 putative PBP binding loops; other site 1423891004937 ABC-ATPase subunit interface; other site 1423891004938 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 1423891004939 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1423891004940 NAD(P) binding site [chemical binding]; other site 1423891004941 catalytic residues [active] 1423891004942 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1423891004943 ABC transporter signature motif; other site 1423891004944 Walker B; other site 1423891004945 D-loop; other site 1423891004946 H-loop/switch region; other site 1423891004947 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1423891004948 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1423891004949 DNA binding site [nucleotide binding] 1423891004950 domain linker motif; other site 1423891004951 Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545 1423891004952 putative dimerization interface [polypeptide binding]; other site 1423891004953 putative ligand binding site [chemical binding]; other site 1423891004954 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1423891004955 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1423891004956 NAD binding site [chemical binding]; other site 1423891004957 substrate binding site [chemical binding]; other site 1423891004958 catalytic Zn binding site [ion binding]; other site 1423891004959 tetramer interface [polypeptide binding]; other site 1423891004960 structural Zn binding site [ion binding]; other site 1423891004961 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1423891004962 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1423891004963 NAD(P) binding site [chemical binding]; other site 1423891004964 catalytic residues [active] 1423891004965 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1423891004966 GAF domain; Region: GAF; pfam01590 1423891004967 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1423891004968 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 1423891004969 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1423891004970 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1423891004971 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1423891004972 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1423891004973 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1423891004974 active site 1423891004975 dimerization interface [polypeptide binding]; other site 1423891004976 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1423891004977 DNA binding residues [nucleotide binding] 1423891004978 dimerization interface [polypeptide binding]; other site 1423891004979 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1423891004980 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1423891004981 ligand binding site [chemical binding]; other site 1423891004982 flexible hinge region; other site 1423891004983 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1423891004984 putative switch regulator; other site 1423891004985 non-specific DNA interactions [nucleotide binding]; other site 1423891004986 DNA binding site [nucleotide binding] 1423891004987 sequence specific DNA binding site [nucleotide binding]; other site 1423891004988 putative cAMP binding site [chemical binding]; other site 1423891004989 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1423891004990 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1423891004991 active site 1423891004992 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1423891004993 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1423891004994 CysD dimerization site [polypeptide binding]; other site 1423891004995 G1 box; other site 1423891004996 putative GEF interaction site [polypeptide binding]; other site 1423891004997 GTP/Mg2+ binding site [chemical binding]; other site 1423891004998 Switch I region; other site 1423891004999 G2 box; other site 1423891005000 G3 box; other site 1423891005001 Switch II region; other site 1423891005002 G4 box; other site 1423891005003 G5 box; other site 1423891005004 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1423891005005 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1423891005006 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1423891005007 ligand-binding site [chemical binding]; other site 1423891005008 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1423891005009 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1423891005010 Active Sites [active] 1423891005011 aminotransferase; Provisional; Region: PRK06105 1423891005012 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1423891005013 inhibitor-cofactor binding pocket; inhibition site 1423891005014 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1423891005015 catalytic residue [active] 1423891005016 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1423891005017 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1423891005018 DNA binding residues [nucleotide binding] 1423891005019 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1423891005020 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1423891005021 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1423891005022 substrate binding pocket [chemical binding]; other site 1423891005023 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1423891005024 B12 binding site [chemical binding]; other site 1423891005025 cobalt ligand [ion binding]; other site 1423891005026 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1423891005027 BA14K-like protein; Region: BA14K; pfam07886 1423891005028 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1423891005029 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1423891005030 active site 1423891005031 DNA binding site [nucleotide binding] 1423891005032 Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876 1423891005033 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3749 1423891005034 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1423891005035 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1423891005036 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1423891005037 Protein of unknown function (DUF2849); Region: DUF2849; pfam11011 1423891005038 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1423891005039 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1423891005040 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1423891005041 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1423891005042 active site 1423891005043 SAM binding site [chemical binding]; other site 1423891005044 homodimer interface [polypeptide binding]; other site 1423891005045 hypothetical protein; Reviewed; Region: PRK12497 1423891005046 Predicted methyltransferases [General function prediction only]; Region: COG0313 1423891005047 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1423891005048 putative SAM binding site [chemical binding]; other site 1423891005049 putative homodimer interface [polypeptide binding]; other site 1423891005050 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 1423891005051 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1423891005052 FeS/SAM binding site; other site 1423891005053 HemN C-terminal domain; Region: HemN_C; pfam06969 1423891005054 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1423891005055 active site 1423891005056 dimerization interface [polypeptide binding]; other site 1423891005057 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1423891005058 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 1423891005059 putative metal binding site [ion binding]; other site 1423891005060 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1423891005061 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1423891005062 heat shock protein GrpE; Provisional; Region: PRK14141 1423891005063 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1423891005064 dimer interface [polypeptide binding]; other site 1423891005065 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1423891005066 Predicted membrane protein [Function unknown]; Region: COG2860 1423891005067 UPF0126 domain; Region: UPF0126; pfam03458 1423891005068 UPF0126 domain; Region: UPF0126; pfam03458 1423891005069 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 1423891005070 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1423891005071 substrate binding site [chemical binding]; other site 1423891005072 ATP binding site [chemical binding]; other site 1423891005073 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 1423891005074 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1423891005075 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1423891005076 minor groove reading motif; other site 1423891005077 helix-hairpin-helix signature motif; other site 1423891005078 substrate binding pocket [chemical binding]; other site 1423891005079 active site 1423891005080 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1423891005081 Integral membrane protein [Function unknown]; Region: COG5488 1423891005082 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1423891005083 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1423891005084 putative dimer interface [polypeptide binding]; other site 1423891005085 Uncharacterized small protein [Function unknown]; Region: COG5568 1423891005086 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1423891005087 active site 1423891005088 phosphorylation site [posttranslational modification] 1423891005089 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1423891005090 30S subunit binding site; other site 1423891005091 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1423891005092 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1423891005093 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1423891005094 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1423891005095 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1423891005096 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1423891005097 Walker A/P-loop; other site 1423891005098 ATP binding site [chemical binding]; other site 1423891005099 Q-loop/lid; other site 1423891005100 ABC transporter signature motif; other site 1423891005101 Walker B; other site 1423891005102 D-loop; other site 1423891005103 H-loop/switch region; other site 1423891005104 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 1423891005105 OstA-like protein; Region: OstA; pfam03968 1423891005106 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 1423891005107 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1423891005108 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1423891005109 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1423891005110 tandem repeat interface [polypeptide binding]; other site 1423891005111 oligomer interface [polypeptide binding]; other site 1423891005112 active site residues [active] 1423891005113 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1423891005114 IHF dimer interface [polypeptide binding]; other site 1423891005115 IHF - DNA interface [nucleotide binding]; other site 1423891005116 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1423891005117 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1423891005118 S-adenosylmethionine binding site [chemical binding]; other site 1423891005119 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1423891005120 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1423891005121 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1423891005122 lipoprotein signal peptidase; Provisional; Region: PRK14795 1423891005123 lipoprotein signal peptidase; Provisional; Region: PRK14787 1423891005124 Putative hemolysin [General function prediction only]; Region: COG3176 1423891005125 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1423891005126 MutS domain I; Region: MutS_I; pfam01624 1423891005127 MutS domain II; Region: MutS_II; pfam05188 1423891005128 MutS domain III; Region: MutS_III; pfam05192 1423891005129 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1423891005130 Walker A/P-loop; other site 1423891005131 ATP binding site [chemical binding]; other site 1423891005132 Q-loop/lid; other site 1423891005133 ABC transporter signature motif; other site 1423891005134 Walker B; other site 1423891005135 D-loop; other site 1423891005136 H-loop/switch region; other site 1423891005137 PII uridylyl-transferase; Provisional; Region: PRK05092 1423891005138 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1423891005139 metal binding triad; other site 1423891005140 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1423891005141 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1423891005142 Zn2+ binding site [ion binding]; other site 1423891005143 Mg2+ binding site [ion binding]; other site 1423891005144 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1423891005145 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1423891005146 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1423891005147 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1423891005148 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1423891005149 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1423891005150 active site 1423891005151 HIGH motif; other site 1423891005152 dimer interface [polypeptide binding]; other site 1423891005153 KMSKS motif; other site 1423891005154 Universal stress protein family; Region: Usp; pfam00582 1423891005155 Ligand Binding Site [chemical binding]; other site 1423891005156 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 1423891005157 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1423891005158 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1423891005159 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1423891005160 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 1423891005161 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1423891005162 active site 1423891005163 phosphorylation site [posttranslational modification] 1423891005164 intermolecular recognition site; other site 1423891005165 dimerization interface [polypeptide binding]; other site 1423891005166 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1423891005167 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 1423891005168 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1423891005169 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1423891005170 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1423891005171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1423891005172 ATP binding site [chemical binding]; other site 1423891005173 Mg2+ binding site [ion binding]; other site 1423891005174 G-X-G motif; other site 1423891005175 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 1423891005176 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1423891005177 ATP binding site [chemical binding]; other site 1423891005178 putative Mg++ binding site [ion binding]; other site 1423891005179 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1423891005180 nucleotide binding region [chemical binding]; other site 1423891005181 ATP-binding site [chemical binding]; other site 1423891005182 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 1423891005183 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1423891005184 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1423891005185 putative metal binding site [ion binding]; other site 1423891005186 putative homodimer interface [polypeptide binding]; other site 1423891005187 putative homotetramer interface [polypeptide binding]; other site 1423891005188 putative homodimer-homodimer interface [polypeptide binding]; other site 1423891005189 putative allosteric switch controlling residues; other site 1423891005190 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1423891005191 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1423891005192 substrate binding site [chemical binding]; other site 1423891005193 catalytic Zn binding site [ion binding]; other site 1423891005194 NAD binding site [chemical binding]; other site 1423891005195 structural Zn binding site [ion binding]; other site 1423891005196 dimer interface [polypeptide binding]; other site 1423891005197 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1423891005198 Coenzyme A binding pocket [chemical binding]; other site 1423891005199 Predicted membrane protein [Function unknown]; Region: COG4291 1423891005200 S-formylglutathione hydrolase; Region: PLN02442 1423891005201 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1423891005202 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1423891005203 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1423891005204 Mg2+ binding site [ion binding]; other site 1423891005205 G-X-G motif; other site 1423891005206 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1423891005207 anchoring element; other site 1423891005208 dimer interface [polypeptide binding]; other site 1423891005209 ATP binding site [chemical binding]; other site 1423891005210 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1423891005211 active site 1423891005212 metal binding site [ion binding]; metal-binding site 1423891005213 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1423891005214 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1423891005215 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1423891005216 ATP binding site [chemical binding]; other site 1423891005217 Mg++ binding site [ion binding]; other site 1423891005218 motif III; other site 1423891005219 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1423891005220 nucleotide binding region [chemical binding]; other site 1423891005221 ATP-binding site [chemical binding]; other site 1423891005222 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 1423891005223 RNA binding site [nucleotide binding]; other site 1423891005224 DNA polymerase I; Region: pola; TIGR00593 1423891005225 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1423891005226 active site 1423891005227 metal binding site 1 [ion binding]; metal-binding site 1423891005228 putative 5' ssDNA interaction site; other site 1423891005229 metal binding site 3; metal-binding site 1423891005230 metal binding site 2 [ion binding]; metal-binding site 1423891005231 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1423891005232 putative DNA binding site [nucleotide binding]; other site 1423891005233 putative metal binding site [ion binding]; other site 1423891005234 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1423891005235 active site 1423891005236 catalytic site [active] 1423891005237 substrate binding site [chemical binding]; other site 1423891005238 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1423891005239 active site 1423891005240 DNA binding site [nucleotide binding] 1423891005241 catalytic site [active] 1423891005242 hypothetical protein; Validated; Region: PRK09104 1423891005243 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 1423891005244 metal binding site [ion binding]; metal-binding site 1423891005245 putative dimer interface [polypeptide binding]; other site 1423891005246 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1423891005247 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1423891005248 catalytic site [active] 1423891005249 putative active site [active] 1423891005250 putative substrate binding site [chemical binding]; other site 1423891005251 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1423891005252 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1423891005253 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1423891005254 Transglycosylase; Region: Transgly; pfam00912 1423891005255 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1423891005256 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1423891005257 classical (c) SDRs; Region: SDR_c; cd05233 1423891005258 NAD(P) binding site [chemical binding]; other site 1423891005259 active site 1423891005260 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1423891005261 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1423891005262 putative substrate binding site [chemical binding]; other site 1423891005263 putative ATP binding site [chemical binding]; other site 1423891005264 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1423891005265 S-adenosylmethionine binding site [chemical binding]; other site 1423891005266 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1423891005267 Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488 1423891005268 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 1423891005269 active site 1423891005270 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1423891005271 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 1423891005272 Putative glucoamylase; Region: Glycoamylase; pfam10091 1423891005273 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 1423891005274 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 1423891005275 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 1423891005276 Protein of unknown function, DUF608; Region: DUF608; pfam04685 1423891005277 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1423891005278 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1423891005279 Walker A/P-loop; other site 1423891005280 ATP binding site [chemical binding]; other site 1423891005281 Q-loop/lid; other site 1423891005282 ABC transporter signature motif; other site 1423891005283 Walker B; other site 1423891005284 D-loop; other site 1423891005285 H-loop/switch region; other site 1423891005286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891005287 dimer interface [polypeptide binding]; other site 1423891005288 conserved gate region; other site 1423891005289 putative PBP binding loops; other site 1423891005290 ABC-ATPase subunit interface; other site 1423891005291 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1423891005292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891005293 dimer interface [polypeptide binding]; other site 1423891005294 conserved gate region; other site 1423891005295 putative PBP binding loops; other site 1423891005296 ABC-ATPase subunit interface; other site 1423891005297 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 1423891005298 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1423891005299 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604 1423891005300 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1423891005301 AsnC family; Region: AsnC_trans_reg; pfam01037 1423891005302 response regulator; Provisional; Region: PRK13435 1423891005303 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1423891005304 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 1423891005305 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1423891005306 catalytic residues [active] 1423891005307 central insert; other site 1423891005308 heme exporter protein CcmD; Region: cytochro_ccmD; TIGR03141 1423891005309 heme exporter protein CcmC; Region: ccmC; TIGR01191 1423891005310 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmB; COG2386 1423891005311 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 1423891005312 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 1423891005313 Walker A/P-loop; other site 1423891005314 ATP binding site [chemical binding]; other site 1423891005315 Q-loop/lid; other site 1423891005316 ABC transporter signature motif; other site 1423891005317 Walker B; other site 1423891005318 D-loop; other site 1423891005319 H-loop/switch region; other site 1423891005320 aconitate hydratase; Validated; Region: PRK09277 1423891005321 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1423891005322 substrate binding site [chemical binding]; other site 1423891005323 ligand binding site [chemical binding]; other site 1423891005324 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1423891005325 substrate binding site [chemical binding]; other site 1423891005326 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1423891005327 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1423891005328 Coenzyme A binding pocket [chemical binding]; other site 1423891005329 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1423891005330 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1423891005331 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1423891005332 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 1423891005333 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1423891005334 Walker A/P-loop; other site 1423891005335 ATP binding site [chemical binding]; other site 1423891005336 Q-loop/lid; other site 1423891005337 ABC transporter signature motif; other site 1423891005338 Walker B; other site 1423891005339 D-loop; other site 1423891005340 H-loop/switch region; other site 1423891005341 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1423891005342 active site 1423891005343 catalytic triad [active] 1423891005344 oxyanion hole [active] 1423891005345 switch loop; other site 1423891005346 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1423891005347 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1423891005348 active site 1423891005349 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 1423891005350 aromatic arch; other site 1423891005351 DCoH dimer interaction site [polypeptide binding]; other site 1423891005352 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1423891005353 DCoH tetramer interaction site [polypeptide binding]; other site 1423891005354 substrate binding site [chemical binding]; other site 1423891005355 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 1423891005356 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1423891005357 FeS/SAM binding site; other site 1423891005358 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1423891005359 argininosuccinate synthase; Provisional; Region: PRK13820 1423891005360 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1423891005361 ANP binding site [chemical binding]; other site 1423891005362 Substrate Binding Site II [chemical binding]; other site 1423891005363 Substrate Binding Site I [chemical binding]; other site 1423891005364 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 1423891005365 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 1423891005366 Haemagglutinin; Region: HIM; pfam05662 1423891005367 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 1423891005368 trimer interface [polypeptide binding]; other site 1423891005369 Haemagglutinin; Region: HIM; pfam05662 1423891005370 YadA-like C-terminal region; Region: YadA; pfam03895 1423891005371 DNA Polymerase Y-family; Region: PolY_like; cd03468 1423891005372 active site 1423891005373 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1423891005374 DNA binding site [nucleotide binding] 1423891005375 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1423891005376 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 1423891005377 putative active site [active] 1423891005378 putative PHP Thumb interface [polypeptide binding]; other site 1423891005379 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1423891005380 generic binding surface II; other site 1423891005381 generic binding surface I; other site 1423891005382 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1423891005383 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1423891005384 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1423891005385 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1423891005386 catalytic residue [active] 1423891005387 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1423891005388 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1423891005389 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 1423891005390 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1423891005391 active site 1423891005392 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1423891005393 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1423891005394 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1423891005395 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1423891005396 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1423891005397 putative effector binding pocket; other site 1423891005398 putative dimerization interface [polypeptide binding]; other site 1423891005399 phosphoglucomutase; Region: PLN02307 1423891005400 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 1423891005401 substrate binding site [chemical binding]; other site 1423891005402 dimer interface [polypeptide binding]; other site 1423891005403 active site 1423891005404 metal binding site [ion binding]; metal-binding site 1423891005405 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1423891005406 Walker A motif; other site 1423891005407 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1423891005408 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1423891005409 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1423891005410 dimer interface [polypeptide binding]; other site 1423891005411 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1423891005412 active site 1423891005413 metal binding site [ion binding]; metal-binding site 1423891005414 glutathione binding site [chemical binding]; other site 1423891005415 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1423891005416 Copper(I)-binding protein [Inorganic ion transport and metabolism]; Region: COG2847 1423891005417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1423891005418 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1423891005419 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1423891005420 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1423891005421 Family of unknown function (DUF490); Region: DUF490; pfam04357 1423891005422 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 1423891005423 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1423891005424 Surface antigen; Region: Bac_surface_Ag; pfam01103 1423891005425 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 1423891005426 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1423891005427 Subunit I/III interface [polypeptide binding]; other site 1423891005428 Subunit III/IV interface [polypeptide binding]; other site 1423891005429 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1423891005430 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1423891005431 D-pathway; other site 1423891005432 Putative ubiquinol binding site [chemical binding]; other site 1423891005433 Low-spin heme (heme b) binding site [chemical binding]; other site 1423891005434 Putative water exit pathway; other site 1423891005435 Binuclear center (heme o3/CuB) [ion binding]; other site 1423891005436 K-pathway; other site 1423891005437 Putative proton exit pathway; other site 1423891005438 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 1423891005439 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1423891005440 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1423891005441 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1423891005442 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 1423891005443 putative MPT binding site; other site 1423891005444 Cytochrome c2 [Energy production and conversion]; Region: COG3474 1423891005445 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1423891005446 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1423891005447 Ligand binding site; other site 1423891005448 oligomer interface; other site 1423891005449 prephenate dehydratase; Provisional; Region: PRK11899 1423891005450 Prephenate dehydratase; Region: PDT; pfam00800 1423891005451 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1423891005452 putative L-Phe binding site [chemical binding]; other site 1423891005453 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 1423891005454 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1423891005455 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1423891005456 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1423891005457 putative NADH binding site [chemical binding]; other site 1423891005458 putative active site [active] 1423891005459 nudix motif; other site 1423891005460 putative metal binding site [ion binding]; other site 1423891005461 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1423891005462 DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111 1423891005463 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1423891005464 Walker A motif; other site 1423891005465 ATP binding site [chemical binding]; other site 1423891005466 Walker B motif; other site 1423891005467 arginine finger; other site 1423891005468 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1423891005469 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 1423891005470 hypothetical protein; Validated; Region: PRK00153 1423891005471 recombination protein RecR; Reviewed; Region: recR; PRK00076 1423891005472 RecR protein; Region: RecR; pfam02132 1423891005473 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1423891005474 putative active site [active] 1423891005475 putative metal-binding site [ion binding]; other site 1423891005476 tetramer interface [polypeptide binding]; other site 1423891005477 lytic murein transglycosylase; Region: MltB_2; TIGR02283 1423891005478 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1423891005479 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1423891005480 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 1423891005481 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1423891005482 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1423891005483 putative dimerization interface [polypeptide binding]; other site 1423891005484 Predicted membrane protein [Function unknown]; Region: COG2855 1423891005485 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1423891005486 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1423891005487 RNA binding site [nucleotide binding]; other site 1423891005488 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1423891005489 RNA binding site [nucleotide binding]; other site 1423891005490 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1423891005491 RNA binding site [nucleotide binding]; other site 1423891005492 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1423891005493 RNA binding site [nucleotide binding]; other site 1423891005494 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1423891005495 RNA binding site [nucleotide binding]; other site 1423891005496 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1423891005497 RNA binding site [nucleotide binding]; other site 1423891005498 cytidylate kinase; Provisional; Region: cmk; PRK00023 1423891005499 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1423891005500 CMP-binding site; other site 1423891005501 The sites determining sugar specificity; other site 1423891005502 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1423891005503 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1423891005504 hinge; other site 1423891005505 active site 1423891005506 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4530 1423891005507 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 1423891005508 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1423891005509 CHRD domain; Region: CHRD; pfam07452 1423891005510 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 1423891005511 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 1423891005512 acyl-activating enzyme (AAE) consensus motif; other site 1423891005513 putative AMP binding site [chemical binding]; other site 1423891005514 putative active site [active] 1423891005515 putative CoA binding site [chemical binding]; other site 1423891005516 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 1423891005517 isovaleryl-CoA dehydrogenase; Region: PLN02519 1423891005518 substrate binding site [chemical binding]; other site 1423891005519 FAD binding site [chemical binding]; other site 1423891005520 catalytic base [active] 1423891005521 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1423891005522 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1423891005523 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1423891005524 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1423891005525 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1423891005526 carboxyltransferase (CT) interaction site; other site 1423891005527 biotinylation site [posttranslational modification]; other site 1423891005528 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1423891005529 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1423891005530 active site 1423891005531 catalytic residues [active] 1423891005532 metal binding site [ion binding]; metal-binding site 1423891005533 enoyl-CoA hydratase; Provisional; Region: PRK07468 1423891005534 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1423891005535 substrate binding site [chemical binding]; other site 1423891005536 oxyanion hole (OAH) forming residues; other site 1423891005537 trimer interface [polypeptide binding]; other site 1423891005538 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1423891005539 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1423891005540 dimerization interface [polypeptide binding]; other site 1423891005541 ligand binding site [chemical binding]; other site 1423891005542 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1423891005543 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1423891005544 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1423891005545 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1423891005546 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 1423891005547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891005548 dimer interface [polypeptide binding]; other site 1423891005549 conserved gate region; other site 1423891005550 putative PBP binding loops; other site 1423891005551 ABC-ATPase subunit interface; other site 1423891005552 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 1423891005553 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891005554 dimer interface [polypeptide binding]; other site 1423891005555 conserved gate region; other site 1423891005556 putative PBP binding loops; other site 1423891005557 ABC-ATPase subunit interface; other site 1423891005558 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 1423891005559 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1423891005560 Walker A/P-loop; other site 1423891005561 ATP binding site [chemical binding]; other site 1423891005562 Q-loop/lid; other site 1423891005563 ABC transporter signature motif; other site 1423891005564 Walker B; other site 1423891005565 D-loop; other site 1423891005566 H-loop/switch region; other site 1423891005567 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1423891005568 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1423891005569 Walker A/P-loop; other site 1423891005570 ATP binding site [chemical binding]; other site 1423891005571 Q-loop/lid; other site 1423891005572 ABC transporter signature motif; other site 1423891005573 Walker B; other site 1423891005574 D-loop; other site 1423891005575 H-loop/switch region; other site 1423891005576 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1423891005577 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1423891005578 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 1423891005579 putative ligand binding site [chemical binding]; other site 1423891005580 NAD binding site [chemical binding]; other site 1423891005581 dimerization interface [polypeptide binding]; other site 1423891005582 catalytic site [active] 1423891005583 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1423891005584 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1423891005585 ATP binding site [chemical binding]; other site 1423891005586 substrate interface [chemical binding]; other site 1423891005587 recombination protein F; Reviewed; Region: recF; PRK00064 1423891005588 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1423891005589 Walker A/P-loop; other site 1423891005590 ATP binding site [chemical binding]; other site 1423891005591 Q-loop/lid; other site 1423891005592 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1423891005593 ABC transporter signature motif; other site 1423891005594 Walker B; other site 1423891005595 D-loop; other site 1423891005596 H-loop/switch region; other site 1423891005597 DNA polymerase III subunit beta; Validated; Region: PRK05643 1423891005598 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1423891005599 putative DNA binding surface [nucleotide binding]; other site 1423891005600 dimer interface [polypeptide binding]; other site 1423891005601 beta-clamp/clamp loader binding surface; other site 1423891005602 beta-clamp/translesion DNA polymerase binding surface; other site 1423891005603 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1423891005604 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1423891005605 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1423891005606 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1423891005607 DnaA box-binding interface [nucleotide binding]; other site 1423891005608 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1423891005609 enoyl-CoA hydratase; Provisional; Region: PRK05862 1423891005610 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1423891005611 substrate binding site [chemical binding]; other site 1423891005612 oxyanion hole (OAH) forming residues; other site 1423891005613 trimer interface [polypeptide binding]; other site 1423891005614 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1423891005615 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1423891005616 DNA binding site [nucleotide binding] 1423891005617 catalytic residue [active] 1423891005618 H2TH interface [polypeptide binding]; other site 1423891005619 putative catalytic residues [active] 1423891005620 turnover-facilitating residue; other site 1423891005621 intercalation triad [nucleotide binding]; other site 1423891005622 8OG recognition residue [nucleotide binding]; other site 1423891005623 putative reading head residues; other site 1423891005624 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1423891005625 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1423891005626 Flp/Fap pilin component; Region: Flp_Fap; cl01585 1423891005627 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1423891005628 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1423891005629 interface (dimer of trimers) [polypeptide binding]; other site 1423891005630 Substrate-binding/catalytic site; other site 1423891005631 Zn-binding sites [ion binding]; other site 1423891005632 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1423891005633 MarR family; Region: MarR; pfam01047 1423891005634 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1423891005635 NlpC/P60 family; Region: NLPC_P60; cl17555 1423891005636 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1423891005637 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1423891005638 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1423891005639 dimerization interface [polypeptide binding]; other site 1423891005640 ligand binding site [chemical binding]; other site 1423891005641 NADP binding site [chemical binding]; other site 1423891005642 catalytic site [active] 1423891005643 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 1423891005644 Bacterial SH3 domain; Region: SH3_4; pfam06347 1423891005645 Bacterial SH3 domain; Region: SH3_4; pfam06347 1423891005646 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1423891005647 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1423891005648 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1423891005649 metal binding site 2 [ion binding]; metal-binding site 1423891005650 putative DNA binding helix; other site 1423891005651 metal binding site 1 [ion binding]; metal-binding site 1423891005652 dimer interface [polypeptide binding]; other site 1423891005653 structural Zn2+ binding site [ion binding]; other site 1423891005654 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 1423891005655 active site 1 [active] 1423891005656 dimer interface [polypeptide binding]; other site 1423891005657 active site 2 [active] 1423891005658 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1423891005659 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1423891005660 dimer interface [polypeptide binding]; other site 1423891005661 active site 1423891005662 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505 1423891005663 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1423891005664 NAD binding site [chemical binding]; other site 1423891005665 homotetramer interface [polypeptide binding]; other site 1423891005666 homodimer interface [polypeptide binding]; other site 1423891005667 substrate binding site [chemical binding]; other site 1423891005668 active site 1423891005669 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1423891005670 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1423891005671 S-adenosylmethionine binding site [chemical binding]; other site 1423891005672 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1423891005673 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1423891005674 RNase E interface [polypeptide binding]; other site 1423891005675 trimer interface [polypeptide binding]; other site 1423891005676 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1423891005677 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1423891005678 RNase E interface [polypeptide binding]; other site 1423891005679 trimer interface [polypeptide binding]; other site 1423891005680 active site 1423891005681 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1423891005682 putative nucleic acid binding region [nucleotide binding]; other site 1423891005683 G-X-X-G motif; other site 1423891005684 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1423891005685 RNA binding site [nucleotide binding]; other site 1423891005686 domain interface; other site 1423891005687 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1423891005688 16S/18S rRNA binding site [nucleotide binding]; other site 1423891005689 S13e-L30e interaction site [polypeptide binding]; other site 1423891005690 25S rRNA binding site [nucleotide binding]; other site 1423891005691 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 1423891005692 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1423891005693 RNA binding site [nucleotide binding]; other site 1423891005694 active site 1423891005695 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1423891005696 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1423891005697 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1423891005698 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1423891005699 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 1423891005700 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1423891005701 G1 box; other site 1423891005702 putative GEF interaction site [polypeptide binding]; other site 1423891005703 GTP/Mg2+ binding site [chemical binding]; other site 1423891005704 Switch I region; other site 1423891005705 G2 box; other site 1423891005706 G3 box; other site 1423891005707 Switch II region; other site 1423891005708 G4 box; other site 1423891005709 G5 box; other site 1423891005710 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1423891005711 Translation-initiation factor 2; Region: IF-2; pfam11987 1423891005712 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1423891005713 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1423891005714 NusA N-terminal domain; Region: NusA_N; pfam08529 1423891005715 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1423891005716 RNA binding site [nucleotide binding]; other site 1423891005717 homodimer interface [polypeptide binding]; other site 1423891005718 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1423891005719 G-X-X-G motif; other site 1423891005720 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1423891005721 G-X-X-G motif; other site 1423891005722 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1423891005723 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1423891005724 Sm and related proteins; Region: Sm_like; cl00259 1423891005725 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1423891005726 putative oligomer interface [polypeptide binding]; other site 1423891005727 putative RNA binding site [nucleotide binding]; other site 1423891005728 Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only]; Region: COG0220 1423891005729 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1423891005730 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1423891005731 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1423891005732 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1423891005733 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1423891005734 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1423891005735 non-specific DNA binding site [nucleotide binding]; other site 1423891005736 salt bridge; other site 1423891005737 sequence-specific DNA binding site [nucleotide binding]; other site 1423891005738 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1423891005739 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1423891005740 putative active site [active] 1423891005741 catalytic triad [active] 1423891005742 putative dimer interface [polypeptide binding]; other site 1423891005743 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 1423891005744 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1423891005745 Transporter associated domain; Region: CorC_HlyC; smart01091 1423891005746 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 1423891005747 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1423891005748 PhoH-like protein; Region: PhoH; pfam02562 1423891005749 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1423891005750 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1423891005751 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1423891005752 FeS/SAM binding site; other site 1423891005753 TRAM domain; Region: TRAM; cl01282 1423891005754 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1423891005755 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1423891005756 putative acyl-acceptor binding pocket; other site 1423891005757 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1423891005758 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1423891005759 Coenzyme A binding pocket [chemical binding]; other site 1423891005760 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 1423891005761 Glycoprotease family; Region: Peptidase_M22; pfam00814 1423891005762 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1423891005763 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1423891005764 dimerization interface [polypeptide binding]; other site 1423891005765 DPS ferroxidase diiron center [ion binding]; other site 1423891005766 ion pore; other site 1423891005767 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1423891005768 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1423891005769 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 1423891005770 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1423891005771 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 1423891005772 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1423891005773 active site 1423891005774 phosphorylation site [posttranslational modification] 1423891005775 intermolecular recognition site; other site 1423891005776 dimerization interface [polypeptide binding]; other site 1423891005777 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1423891005778 DNA binding site [nucleotide binding] 1423891005779 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1423891005780 PhoU domain; Region: PhoU; pfam01895 1423891005781 PhoU domain; Region: PhoU; pfam01895 1423891005782 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 1423891005783 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1423891005784 Walker A/P-loop; other site 1423891005785 ATP binding site [chemical binding]; other site 1423891005786 Q-loop/lid; other site 1423891005787 ABC transporter signature motif; other site 1423891005788 Walker B; other site 1423891005789 D-loop; other site 1423891005790 H-loop/switch region; other site 1423891005791 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 1423891005792 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1423891005793 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891005794 dimer interface [polypeptide binding]; other site 1423891005795 conserved gate region; other site 1423891005796 putative PBP binding loops; other site 1423891005797 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1423891005798 ABC-ATPase subunit interface; other site 1423891005799 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 1423891005800 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1423891005801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891005802 dimer interface [polypeptide binding]; other site 1423891005803 conserved gate region; other site 1423891005804 putative PBP binding loops; other site 1423891005805 ABC-ATPase subunit interface; other site 1423891005806 PBP superfamily domain; Region: PBP_like_2; pfam12849 1423891005807 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 1423891005808 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1423891005809 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1423891005810 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 1423891005811 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1423891005812 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1423891005813 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1423891005814 Walker A motif; other site 1423891005815 ATP binding site [chemical binding]; other site 1423891005816 Walker B motif; other site 1423891005817 arginine finger; other site 1423891005818 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1423891005819 glutathione synthetase; Provisional; Region: PRK05246 1423891005820 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1423891005821 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1423891005822 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1423891005823 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1423891005824 active site 1423891005825 dimer interface [polypeptide binding]; other site 1423891005826 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1423891005827 S-adenosylmethionine binding site [chemical binding]; other site 1423891005828 chaperone protein DnaJ; Provisional; Region: PRK10767 1423891005829 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1423891005830 HSP70 interaction site [polypeptide binding]; other site 1423891005831 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1423891005832 substrate binding site [polypeptide binding]; other site 1423891005833 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1423891005834 Zn binding sites [ion binding]; other site 1423891005835 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1423891005836 dimer interface [polypeptide binding]; other site 1423891005837 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1423891005838 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 1423891005839 nucleotide binding site [chemical binding]; other site 1423891005840 NEF interaction site [polypeptide binding]; other site 1423891005841 SBD interface [polypeptide binding]; other site 1423891005842 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1423891005843 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1423891005844 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1423891005845 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1423891005846 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1423891005847 putative tRNA-binding site [nucleotide binding]; other site 1423891005848 B3/4 domain; Region: B3_4; pfam03483 1423891005849 tRNA synthetase B5 domain; Region: B5; smart00874 1423891005850 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1423891005851 dimer interface [polypeptide binding]; other site 1423891005852 motif 1; other site 1423891005853 motif 3; other site 1423891005854 motif 2; other site 1423891005855 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 1423891005856 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1423891005857 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1423891005858 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1423891005859 dimer interface [polypeptide binding]; other site 1423891005860 motif 1; other site 1423891005861 active site 1423891005862 motif 2; other site 1423891005863 motif 3; other site 1423891005864 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1423891005865 23S rRNA binding site [nucleotide binding]; other site 1423891005866 L21 binding site [polypeptide binding]; other site 1423891005867 L13 binding site [polypeptide binding]; other site 1423891005868 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1423891005869 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1423891005870 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1423891005871 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1423891005872 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1423891005873 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1423891005874 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1423891005875 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 1423891005876 benzoate transporter; Region: benE; TIGR00843 1423891005877 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 1423891005878 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1423891005879 active site 1423891005880 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1423891005881 substrate binding site [chemical binding]; other site 1423891005882 active site 1423891005883 catalytic residues [active] 1423891005884 heterodimer interface [polypeptide binding]; other site 1423891005885 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1423891005886 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1423891005887 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1423891005888 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1423891005889 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1423891005890 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1423891005891 catalytic residues [active] 1423891005892 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 1423891005893 Part of AAA domain; Region: AAA_19; pfam13245 1423891005894 Family description; Region: UvrD_C_2; pfam13538 1423891005895 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1423891005896 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 1423891005897 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1423891005898 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1423891005899 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 1423891005900 Substrate binding site; other site 1423891005901 metal-binding site 1423891005902 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1423891005903 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 1423891005904 Phosphotransferase enzyme family; Region: APH; pfam01636 1423891005905 PAS fold; Region: PAS_7; pfam12860 1423891005906 PAS fold; Region: PAS_7; pfam12860 1423891005907 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1423891005908 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1423891005909 dimer interface [polypeptide binding]; other site 1423891005910 phosphorylation site [posttranslational modification] 1423891005911 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1423891005912 ATP binding site [chemical binding]; other site 1423891005913 Mg2+ binding site [ion binding]; other site 1423891005914 G-X-G motif; other site 1423891005915 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1423891005916 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1423891005917 homotetramer interface [polypeptide binding]; other site 1423891005918 ligand binding site [chemical binding]; other site 1423891005919 catalytic site [active] 1423891005920 NAD binding site [chemical binding]; other site 1423891005921 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1423891005922 dimerization domain swap beta strand [polypeptide binding]; other site 1423891005923 regulatory protein interface [polypeptide binding]; other site 1423891005924 active site 1423891005925 regulatory phosphorylation site [posttranslational modification]; other site 1423891005926 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1423891005927 active pocket/dimerization site; other site 1423891005928 active site 1423891005929 phosphorylation site [posttranslational modification] 1423891005930 Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755 1423891005931 Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756 1423891005932 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1423891005933 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1423891005934 dimerization interface [polypeptide binding]; other site 1423891005935 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1423891005936 dimer interface [polypeptide binding]; other site 1423891005937 phosphorylation site [posttranslational modification] 1423891005938 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1423891005939 ATP binding site [chemical binding]; other site 1423891005940 Mg2+ binding site [ion binding]; other site 1423891005941 G-X-G motif; other site 1423891005942 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1423891005943 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1423891005944 active site 1423891005945 phosphorylation site [posttranslational modification] 1423891005946 intermolecular recognition site; other site 1423891005947 dimerization interface [polypeptide binding]; other site 1423891005948 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1423891005949 DNA binding site [nucleotide binding] 1423891005950 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1423891005951 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1423891005952 active site 1423891005953 substrate-binding site [chemical binding]; other site 1423891005954 metal-binding site [ion binding] 1423891005955 ATP binding site [chemical binding]; other site 1423891005956 hypothetical protein; Provisional; Region: PRK09256 1423891005957 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1423891005958 pantothenate kinase; Provisional; Region: PRK05439 1423891005959 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1423891005960 ATP-binding site [chemical binding]; other site 1423891005961 CoA-binding site [chemical binding]; other site 1423891005962 Mg2+-binding site [ion binding]; other site 1423891005963 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1423891005964 metal binding site [ion binding]; metal-binding site 1423891005965 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1423891005966 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1423891005967 substrate binding site [chemical binding]; other site 1423891005968 glutamase interaction surface [polypeptide binding]; other site 1423891005969 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1423891005970 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1423891005971 catalytic residues [active] 1423891005972 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1423891005973 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1423891005974 putative active site [active] 1423891005975 oxyanion strand; other site 1423891005976 catalytic triad [active] 1423891005977 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1423891005978 putative active site pocket [active] 1423891005979 4-fold oligomerization interface [polypeptide binding]; other site 1423891005980 metal binding residues [ion binding]; metal-binding site 1423891005981 3-fold/trimer interface [polypeptide binding]; other site 1423891005982 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1423891005983 active site 1423891005984 HslU subunit interaction site [polypeptide binding]; other site 1423891005985 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1423891005986 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1423891005987 Walker A motif; other site 1423891005988 ATP binding site [chemical binding]; other site 1423891005989 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1423891005990 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1423891005991 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1423891005992 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1423891005993 sequence-specific DNA binding site [nucleotide binding]; other site 1423891005994 salt bridge; other site 1423891005995 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 1423891005996 Smr domain; Region: Smr; pfam01713 1423891005997 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 1423891005998 MltA specific insert domain; Region: MltA; pfam03562 1423891005999 3D domain; Region: 3D; pfam06725 1423891006000 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 1423891006001 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 1423891006002 preprotein translocase subunit SecB; Validated; Region: PRK05751 1423891006003 SecA binding site; other site 1423891006004 Preprotein binding site; other site 1423891006005 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1423891006006 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1423891006007 active site 1423891006008 catalytic site [active] 1423891006009 substrate binding site [chemical binding]; other site 1423891006010 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1423891006011 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1423891006012 CoA-binding site [chemical binding]; other site 1423891006013 ATP-binding [chemical binding]; other site 1423891006014 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1423891006015 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1423891006016 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1423891006017 shikimate binding site; other site 1423891006018 NAD(P) binding site [chemical binding]; other site 1423891006019 Maf-like protein; Reviewed; Region: PRK00078 1423891006020 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1423891006021 active site 1423891006022 dimer interface [polypeptide binding]; other site 1423891006023 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1423891006024 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1423891006025 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 1423891006026 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1423891006027 Walker A/P-loop; other site 1423891006028 ATP binding site [chemical binding]; other site 1423891006029 Q-loop/lid; other site 1423891006030 ABC transporter signature motif; other site 1423891006031 Walker B; other site 1423891006032 D-loop; other site 1423891006033 H-loop/switch region; other site 1423891006034 TOBE domain; Region: TOBE; cl01440 1423891006035 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891006036 dimer interface [polypeptide binding]; other site 1423891006037 conserved gate region; other site 1423891006038 putative PBP binding loops; other site 1423891006039 ABC-ATPase subunit interface; other site 1423891006040 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1423891006041 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1423891006042 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 1423891006043 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1423891006044 active site residue [active] 1423891006045 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 1423891006046 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1423891006047 active site 1423891006048 intersubunit interface [polypeptide binding]; other site 1423891006049 catalytic residue [active] 1423891006050 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 1423891006051 Bacterial protein of unknown function (DUF882); Region: Peptidase_M15_2; pfam05951 1423891006052 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1423891006053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1423891006054 active site 1423891006055 phosphorylation site [posttranslational modification] 1423891006056 intermolecular recognition site; other site 1423891006057 dimerization interface [polypeptide binding]; other site 1423891006058 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1423891006059 Walker A motif; other site 1423891006060 ATP binding site [chemical binding]; other site 1423891006061 Walker B motif; other site 1423891006062 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1423891006063 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 1423891006064 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 1423891006065 active site 1423891006066 Zn binding site [ion binding]; other site 1423891006067 aminodeoxychorismate synthase; Provisional; Region: PRK07508 1423891006068 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1423891006069 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 1423891006070 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 1423891006071 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1423891006072 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1423891006073 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1423891006074 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1423891006075 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1423891006076 putative active site [active] 1423891006077 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1423891006078 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1423891006079 active site 1423891006080 tetramer interface; other site 1423891006081 lytic murein transglycosylase; Region: MltB_2; TIGR02283 1423891006082 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1423891006083 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1423891006084 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1423891006085 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1423891006086 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1423891006087 catalytic residue [active] 1423891006088 TrbC/VIRB2 family; Region: TrbC; pfam04956 1423891006089 Type IV secretory pathway, VirB3 components [Intracellular trafficking and secretion]; Region: VirB3; COG3702 1423891006090 Type IV secretory pathway, VirB4 components [Intracellular trafficking and secretion]; Region: VirB4; COG3451 1423891006091 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 1423891006092 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 1423891006093 Type IV secretion system proteins; Region: T4SS; pfam07996 1423891006094 Type IV secretory pathway, VirB6 components [Intracellular trafficking and secretion]; Region: VirB6; COG3704 1423891006095 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1423891006096 Type IV secretory pathway, component VirB8 [Intracellular trafficking and secretion]; Region: VirB8; COG3736 1423891006097 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 1423891006098 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 1423891006099 VirB7 interaction site; other site 1423891006100 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 1423891006101 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 1423891006102 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1423891006103 ATP binding site [chemical binding]; other site 1423891006104 Walker A motif; other site 1423891006105 hexamer interface [polypeptide binding]; other site 1423891006106 Walker B motif; other site 1423891006107 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1423891006108 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1423891006109 ligand binding site [chemical binding]; other site 1423891006110 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 1423891006111 active site 1423891006112 oxyanion hole [active] 1423891006113 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1423891006114 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1423891006115 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1423891006116 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1423891006117 active site 1423891006118 dimer interface [polypeptide binding]; other site 1423891006119 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1423891006120 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1423891006121 active site 1423891006122 FMN binding site [chemical binding]; other site 1423891006123 substrate binding site [chemical binding]; other site 1423891006124 3Fe-4S cluster binding site [ion binding]; other site 1423891006125 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1423891006126 domain interface; other site 1423891006127 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1423891006128 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1423891006129 tetramer interface [polypeptide binding]; other site 1423891006130 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1423891006131 catalytic residue [active] 1423891006132 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1423891006133 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1423891006134 putative dimer interface [polypeptide binding]; other site 1423891006135 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 1423891006136 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1423891006137 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1423891006138 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 1423891006139 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1423891006140 active site 1423891006141 N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: HutG; COG3741 1423891006142 Response regulator receiver domain; Region: Response_reg; pfam00072 1423891006143 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1423891006144 active site 1423891006145 phosphorylation site [posttranslational modification] 1423891006146 intermolecular recognition site; other site 1423891006147 dimerization interface [polypeptide binding]; other site 1423891006148 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1423891006149 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1423891006150 active site 1423891006151 phosphorylation site [posttranslational modification] 1423891006152 intermolecular recognition site; other site 1423891006153 dimerization interface [polypeptide binding]; other site 1423891006154 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1423891006155 dimerization interface [polypeptide binding]; other site 1423891006156 DNA binding residues [nucleotide binding] 1423891006157 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1423891006158 ATP binding site [chemical binding]; other site 1423891006159 Mg2+ binding site [ion binding]; other site 1423891006160 G-X-G motif; other site 1423891006161 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1423891006162 MgtC family; Region: MgtC; pfam02308 1423891006163 magnesium-transporting ATPase; Provisional; Region: PRK15122 1423891006164 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1423891006165 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1423891006166 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1423891006167 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1423891006168 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1423891006169 shikimate binding site; other site 1423891006170 NAD(P) binding site [chemical binding]; other site 1423891006171 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1423891006172 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1423891006173 E3 interaction surface; other site 1423891006174 lipoyl attachment site [posttranslational modification]; other site 1423891006175 e3 binding domain; Region: E3_binding; pfam02817 1423891006176 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1423891006177 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1423891006178 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1423891006179 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1423891006180 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1423891006181 tetramer interface [polypeptide binding]; other site 1423891006182 TPP-binding site [chemical binding]; other site 1423891006183 heterodimer interface [polypeptide binding]; other site 1423891006184 phosphorylation loop region [posttranslational modification] 1423891006185 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1423891006186 PYR/PP interface [polypeptide binding]; other site 1423891006187 dimer interface [polypeptide binding]; other site 1423891006188 TPP binding site [chemical binding]; other site 1423891006189 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1423891006190 classical (c) SDRs; Region: SDR_c; cd05233 1423891006191 NAD(P) binding site [chemical binding]; other site 1423891006192 active site 1423891006193 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1423891006194 classical (c) SDRs; Region: SDR_c; cd05233 1423891006195 NAD(P) binding site [chemical binding]; other site 1423891006196 active site 1423891006197 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1423891006198 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1423891006199 active site 1423891006200 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1423891006201 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1423891006202 Walker A/P-loop; other site 1423891006203 ATP binding site [chemical binding]; other site 1423891006204 Q-loop/lid; other site 1423891006205 ABC transporter signature motif; other site 1423891006206 Walker B; other site 1423891006207 D-loop; other site 1423891006208 H-loop/switch region; other site 1423891006209 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1423891006210 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1423891006211 TM-ABC transporter signature motif; other site 1423891006212 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1423891006213 TM-ABC transporter signature motif; other site 1423891006214 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1423891006215 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 1423891006216 putative ligand binding site [chemical binding]; other site 1423891006217 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1423891006218 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1423891006219 DNA-binding site [nucleotide binding]; DNA binding site 1423891006220 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1423891006221 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4944 1423891006222 RNA polymerase sigma factor; Provisional; Region: PRK12539 1423891006223 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1423891006224 pentapeptide MXKDX repeat protein; Region: penta_MxKDx; TIGR02953 1423891006225 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 1423891006226 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 1423891006227 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1423891006228 bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108 1423891006229 Moco binding site; other site 1423891006230 metal coordination site [ion binding]; other site 1423891006231 Condensation domain; Region: Condensation; pfam00668 1423891006232 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1423891006233 isochorismate synthases; Region: isochor_syn; TIGR00543 1423891006234 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 1423891006235 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1423891006236 acyl-activating enzyme (AAE) consensus motif; other site 1423891006237 active site 1423891006238 AMP binding site [chemical binding]; other site 1423891006239 substrate binding site [chemical binding]; other site 1423891006240 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1423891006241 hydrophobic substrate binding pocket; other site 1423891006242 Isochorismatase family; Region: Isochorismatase; pfam00857 1423891006243 active site 1423891006244 conserved cis-peptide bond; other site 1423891006245 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1423891006246 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 1423891006247 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 1423891006248 putative NAD(P) binding site [chemical binding]; other site 1423891006249 active site 1423891006250 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1423891006251 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1423891006252 Predicted secreted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5664 1423891006253 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1423891006254 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1423891006255 ligand binding site [chemical binding]; other site 1423891006256 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1423891006257 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1423891006258 Walker A/P-loop; other site 1423891006259 ATP binding site [chemical binding]; other site 1423891006260 Q-loop/lid; other site 1423891006261 ABC transporter signature motif; other site 1423891006262 Walker B; other site 1423891006263 D-loop; other site 1423891006264 H-loop/switch region; other site 1423891006265 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1423891006266 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1423891006267 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1423891006268 TM-ABC transporter signature motif; other site 1423891006269 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1423891006270 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1423891006271 TM-ABC transporter signature motif; other site 1423891006272 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1423891006273 active site 1423891006274 tetramer interface [polypeptide binding]; other site 1423891006275 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1423891006276 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1423891006277 substrate binding site [chemical binding]; other site 1423891006278 dimer interface [polypeptide binding]; other site 1423891006279 ATP binding site [chemical binding]; other site 1423891006280 replication initiation protein RepC; Provisional; Region: PRK13824 1423891006281 Replication protein C N-terminal domain; Region: RP-C; pfam03428 1423891006282 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 1423891006283 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 1423891006284 ParB-like nuclease domain; Region: ParB; smart00470 1423891006285 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 1423891006286 MerR family regulatory protein; Region: MerR; pfam00376 1423891006287 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1423891006288 P-loop; other site 1423891006289 Magnesium ion binding site [ion binding]; other site 1423891006290 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1423891006291 P-loop; other site 1423891006292 Magnesium ion binding site [ion binding]; other site 1423891006293 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1423891006294 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1423891006295 FeS/SAM binding site; other site 1423891006296 HemN C-terminal domain; Region: HemN_C; pfam06969 1423891006297 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1423891006298 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1423891006299 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1423891006300 Walker A/P-loop; other site 1423891006301 ATP binding site [chemical binding]; other site 1423891006302 Q-loop/lid; other site 1423891006303 ABC transporter signature motif; other site 1423891006304 Walker B; other site 1423891006305 D-loop; other site 1423891006306 H-loop/switch region; other site 1423891006307 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1423891006308 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1423891006309 Walker A/P-loop; other site 1423891006310 ATP binding site [chemical binding]; other site 1423891006311 Q-loop/lid; other site 1423891006312 ABC transporter signature motif; other site 1423891006313 Walker B; other site 1423891006314 D-loop; other site 1423891006315 H-loop/switch region; other site 1423891006316 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1423891006317 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1423891006318 TM-ABC transporter signature motif; other site 1423891006319 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1423891006320 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1423891006321 TM-ABC transporter signature motif; other site 1423891006322 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1423891006323 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_5; cd06338 1423891006324 putative ligand binding site [chemical binding]; other site 1423891006325 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1423891006326 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1423891006327 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 1423891006328 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1423891006329 N-terminal plug; other site 1423891006330 ligand-binding site [chemical binding]; other site 1423891006331 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1423891006332 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1423891006333 nucleotide binding site [chemical binding]; other site 1423891006334 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1423891006335 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891006336 dimer interface [polypeptide binding]; other site 1423891006337 conserved gate region; other site 1423891006338 putative PBP binding loops; other site 1423891006339 ABC-ATPase subunit interface; other site 1423891006340 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1423891006341 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1423891006342 Walker A/P-loop; other site 1423891006343 ATP binding site [chemical binding]; other site 1423891006344 Q-loop/lid; other site 1423891006345 ABC transporter signature motif; other site 1423891006346 Walker B; other site 1423891006347 D-loop; other site 1423891006348 H-loop/switch region; other site 1423891006349 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1423891006350 NMT1-like family; Region: NMT1_2; pfam13379 1423891006351 substrate binding pocket [chemical binding]; other site 1423891006352 membrane-bound complex binding site; other site 1423891006353 hinge residues; other site 1423891006354 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1423891006355 Sulfatase; Region: Sulfatase; cl17466 1423891006356 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1423891006357 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1423891006358 active site 1423891006359 metal binding site [ion binding]; metal-binding site 1423891006360 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1423891006361 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1423891006362 Walker A/P-loop; other site 1423891006363 ATP binding site [chemical binding]; other site 1423891006364 Q-loop/lid; other site 1423891006365 ABC transporter signature motif; other site 1423891006366 Walker B; other site 1423891006367 D-loop; other site 1423891006368 H-loop/switch region; other site 1423891006369 TOBE domain; Region: TOBE_2; pfam08402 1423891006370 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1423891006371 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891006372 dimer interface [polypeptide binding]; other site 1423891006373 conserved gate region; other site 1423891006374 putative PBP binding loops; other site 1423891006375 ABC-ATPase subunit interface; other site 1423891006376 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1423891006377 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1423891006378 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1423891006379 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1423891006380 DNA-binding site [nucleotide binding]; DNA binding site 1423891006381 UTRA domain; Region: UTRA; pfam07702 1423891006382 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1423891006383 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 1423891006384 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1423891006385 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1423891006386 Walker A/P-loop; other site 1423891006387 ATP binding site [chemical binding]; other site 1423891006388 Q-loop/lid; other site 1423891006389 ABC transporter signature motif; other site 1423891006390 Walker B; other site 1423891006391 D-loop; other site 1423891006392 H-loop/switch region; other site 1423891006393 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1423891006394 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1423891006395 TM-ABC transporter signature motif; other site 1423891006396 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1423891006397 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1423891006398 Walker A/P-loop; other site 1423891006399 ATP binding site [chemical binding]; other site 1423891006400 Q-loop/lid; other site 1423891006401 ABC transporter signature motif; other site 1423891006402 Walker B; other site 1423891006403 D-loop; other site 1423891006404 H-loop/switch region; other site 1423891006405 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1423891006406 TM-ABC transporter signature motif; other site 1423891006407 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1423891006408 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 1423891006409 putative ligand binding site [chemical binding]; other site 1423891006410 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1423891006411 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1423891006412 active site 1423891006413 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1423891006414 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 1423891006415 NAD(P) binding site [chemical binding]; other site 1423891006416 catalytic residues [active] 1423891006417 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1423891006418 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1423891006419 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1423891006420 Bacterial transcriptional regulator; Region: IclR; pfam01614 1423891006421 Uncharacterized conserved protein [Function unknown]; Region: COG5441; cl02262 1423891006422 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 1423891006423 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1423891006424 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1423891006425 motif II; other site 1423891006426 hypothetical protein; Provisional; Region: PRK07481 1423891006427 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1423891006428 inhibitor-cofactor binding pocket; inhibition site 1423891006429 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1423891006430 catalytic residue [active] 1423891006431 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1423891006432 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1423891006433 inhibitor-cofactor binding pocket; inhibition site 1423891006434 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1423891006435 catalytic residue [active] 1423891006436 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1423891006437 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1423891006438 active site 1423891006439 ATP binding site [chemical binding]; other site 1423891006440 substrate binding site [chemical binding]; other site 1423891006441 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 1423891006442 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1423891006443 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 1423891006444 putative substrate binding pocket [chemical binding]; other site 1423891006445 trimer interface [polypeptide binding]; other site 1423891006446 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 1423891006447 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1423891006448 NAD binding site [chemical binding]; other site 1423891006449 catalytic residues [active] 1423891006450 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 1423891006451 N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266 1423891006452 tetramer interface [polypeptide binding]; other site 1423891006453 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 1423891006454 tetramer interface [polypeptide binding]; other site 1423891006455 active site 1423891006456 metal binding site [ion binding]; metal-binding site 1423891006457 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1423891006458 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1423891006459 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 1423891006460 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Region: HpaI; TIGR02311 1423891006461 choline dehydrogenase; Validated; Region: PRK02106 1423891006462 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 1423891006463 HTH domain; Region: HTH_11; cl17392 1423891006464 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1423891006465 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1423891006466 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1423891006467 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1423891006468 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1423891006469 TM-ABC transporter signature motif; other site 1423891006470 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 1423891006471 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1423891006472 Walker A/P-loop; other site 1423891006473 ATP binding site [chemical binding]; other site 1423891006474 Q-loop/lid; other site 1423891006475 ABC transporter signature motif; other site 1423891006476 Walker B; other site 1423891006477 D-loop; other site 1423891006478 H-loop/switch region; other site 1423891006479 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1423891006480 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1423891006481 D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634 1423891006482 putative ligand binding site [chemical binding]; other site 1423891006483 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1423891006484 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1423891006485 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1423891006486 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1423891006487 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 1423891006488 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1423891006489 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1423891006490 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1423891006491 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1423891006492 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1423891006493 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1423891006494 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1423891006495 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1423891006496 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1423891006497 flagellar motor protein MotB; Validated; Region: motB; PRK05996 1423891006498 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1423891006499 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1423891006500 ligand binding site [chemical binding]; other site 1423891006501 chemotaxis protein; Reviewed; Region: PRK12798 1423891006502 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1423891006503 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1423891006504 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1423891006505 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1423891006506 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1423891006507 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1423891006508 DNA binding site [nucleotide binding] 1423891006509 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1423891006510 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1423891006511 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1423891006512 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1423891006513 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 1423891006514 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1423891006515 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008 1423891006516 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1423891006517 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1423891006518 Flagellar biosynthesis regulator FlaF [Cell motility and secretion]; Region: FlaF; COG5442 1423891006519 flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793 1423891006520 Flagellar biosynthesis regulator FlbT [Cell motility and secretion]; Region: FlbT; COG5443 1423891006521 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009 1423891006522 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1423891006523 flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010 1423891006524 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 1423891006525 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 1423891006526 Rod binding protein; Region: Rod-binding; pfam10135 1423891006527 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1423891006528 metal binding site 2 [ion binding]; metal-binding site 1423891006529 putative DNA binding helix; other site 1423891006530 metal binding site 1 [ion binding]; metal-binding site 1423891006531 dimer interface [polypeptide binding]; other site 1423891006532 structural Zn2+ binding site [ion binding]; other site 1423891006533 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1423891006534 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1423891006535 ABC-ATPase subunit interface; other site 1423891006536 dimer interface [polypeptide binding]; other site 1423891006537 putative PBP binding regions; other site 1423891006538 ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531 1423891006539 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 1423891006540 metal binding site [ion binding]; metal-binding site 1423891006541 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1423891006542 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1423891006543 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1423891006544 Rrf2 family protein; Region: rrf2_super; TIGR00738 1423891006545 Transcriptional regulator; Region: Rrf2; pfam02082 1423891006546 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 1423891006547 putative transposase OrfB; Reviewed; Region: PHA02517 1423891006548 HTH-like domain; Region: HTH_21; pfam13276 1423891006549 Integrase core domain; Region: rve; pfam00665 1423891006550 Integrase core domain; Region: rve_3; pfam13683 1423891006551 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 1423891006552 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1423891006553 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235 1423891006554 intersubunit interface [polypeptide binding]; other site 1423891006555 active site 1423891006556 Zn2+ binding site [ion binding]; other site 1423891006557 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1423891006558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891006559 dimer interface [polypeptide binding]; other site 1423891006560 conserved gate region; other site 1423891006561 putative PBP binding loops; other site 1423891006562 ABC-ATPase subunit interface; other site 1423891006563 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1423891006564 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1423891006565 amidase; Provisional; Region: PRK07486 1423891006566 Amidase; Region: Amidase; cl11426 1423891006567 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1423891006568 Walker A/P-loop; other site 1423891006569 ATP binding site [chemical binding]; other site 1423891006570 Q-loop/lid; other site 1423891006571 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1423891006572 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1423891006573 Walker A/P-loop; other site 1423891006574 ATP binding site [chemical binding]; other site 1423891006575 Q-loop/lid; other site 1423891006576 ABC transporter signature motif; other site 1423891006577 Walker B; other site 1423891006578 D-loop; other site 1423891006579 H-loop/switch region; other site 1423891006580 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1423891006581 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1423891006582 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891006583 dimer interface [polypeptide binding]; other site 1423891006584 conserved gate region; other site 1423891006585 putative PBP binding loops; other site 1423891006586 ABC-ATPase subunit interface; other site 1423891006587 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1423891006588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891006589 dimer interface [polypeptide binding]; other site 1423891006590 conserved gate region; other site 1423891006591 putative PBP binding loops; other site 1423891006592 ABC-ATPase subunit interface; other site 1423891006593 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1423891006594 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 1423891006595 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1423891006596 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1423891006597 DNA-binding site [nucleotide binding]; DNA binding site 1423891006598 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1423891006599 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1423891006600 Walker A/P-loop; other site 1423891006601 ATP binding site [chemical binding]; other site 1423891006602 Q-loop/lid; other site 1423891006603 ABC transporter signature motif; other site 1423891006604 Walker B; other site 1423891006605 D-loop; other site 1423891006606 H-loop/switch region; other site 1423891006607 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1423891006608 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1423891006609 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1423891006610 Walker A/P-loop; other site 1423891006611 ATP binding site [chemical binding]; other site 1423891006612 Q-loop/lid; other site 1423891006613 ABC transporter signature motif; other site 1423891006614 Walker B; other site 1423891006615 D-loop; other site 1423891006616 H-loop/switch region; other site 1423891006617 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1423891006618 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1423891006619 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891006620 dimer interface [polypeptide binding]; other site 1423891006621 conserved gate region; other site 1423891006622 putative PBP binding loops; other site 1423891006623 ABC-ATPase subunit interface; other site 1423891006624 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1423891006625 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891006626 dimer interface [polypeptide binding]; other site 1423891006627 conserved gate region; other site 1423891006628 putative PBP binding loops; other site 1423891006629 ABC-ATPase subunit interface; other site 1423891006630 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1423891006631 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 1423891006632 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 1423891006633 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1423891006634 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 1423891006635 active site 1423891006636 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1423891006637 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1423891006638 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1423891006639 active site 1423891006640 enoyl-CoA hydratase; Provisional; Region: PRK08138 1423891006641 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1423891006642 substrate binding site [chemical binding]; other site 1423891006643 oxyanion hole (OAH) forming residues; other site 1423891006644 trimer interface [polypeptide binding]; other site 1423891006645 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 1423891006646 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1423891006647 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1423891006648 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1423891006649 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1423891006650 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1423891006651 tetramer interface [polypeptide binding]; other site 1423891006652 TPP-binding site [chemical binding]; other site 1423891006653 heterodimer interface [polypeptide binding]; other site 1423891006654 phosphorylation loop region [posttranslational modification] 1423891006655 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1423891006656 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1423891006657 alpha subunit interface [polypeptide binding]; other site 1423891006658 TPP binding site [chemical binding]; other site 1423891006659 heterodimer interface [polypeptide binding]; other site 1423891006660 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1423891006661 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1423891006662 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 1423891006663 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 1423891006664 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1423891006665 E3 interaction surface; other site 1423891006666 lipoyl attachment site [posttranslational modification]; other site 1423891006667 e3 binding domain; Region: E3_binding; pfam02817 1423891006668 Serine hydrolase; Region: Ser_hydrolase; cl17834 1423891006669 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1423891006670 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1423891006671 Bacterial transcriptional regulator; Region: IclR; pfam01614 1423891006672 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1423891006673 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891006674 dimer interface [polypeptide binding]; other site 1423891006675 conserved gate region; other site 1423891006676 putative PBP binding loops; other site 1423891006677 ABC-ATPase subunit interface; other site 1423891006678 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1423891006679 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 1423891006680 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1423891006681 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1423891006682 Walker A/P-loop; other site 1423891006683 ATP binding site [chemical binding]; other site 1423891006684 Q-loop/lid; other site 1423891006685 ABC transporter signature motif; other site 1423891006686 Walker B; other site 1423891006687 D-loop; other site 1423891006688 H-loop/switch region; other site 1423891006689 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1423891006690 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1423891006691 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1423891006692 Walker A/P-loop; other site 1423891006693 ATP binding site [chemical binding]; other site 1423891006694 Q-loop/lid; other site 1423891006695 ABC transporter signature motif; other site 1423891006696 Walker B; other site 1423891006697 D-loop; other site 1423891006698 H-loop/switch region; other site 1423891006699 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1423891006700 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1423891006701 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1423891006702 tetramerization interface [polypeptide binding]; other site 1423891006703 NAD(P) binding site [chemical binding]; other site 1423891006704 catalytic residues [active] 1423891006705 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1423891006706 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1423891006707 DNA-binding site [nucleotide binding]; DNA binding site 1423891006708 FCD domain; Region: FCD; pfam07729 1423891006709 putative transposase OrfB; Reviewed; Region: PHA02517 1423891006710 HTH-like domain; Region: HTH_21; pfam13276 1423891006711 Integrase core domain; Region: rve; pfam00665 1423891006712 Integrase core domain; Region: rve_3; pfam13683 1423891006713 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1423891006714 hypothetical protein; Provisional; Region: PRK00736 1423891006715 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1423891006716 active site 1423891006717 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1423891006718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1423891006719 S-adenosylmethionine binding site [chemical binding]; other site 1423891006720 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1423891006721 ABC1 family; Region: ABC1; pfam03109 1423891006722 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1423891006723 active site 1423891006724 ATP binding site [chemical binding]; other site 1423891006725 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1423891006726 substrate binding site [chemical binding]; other site 1423891006727 activation loop (A-loop); other site 1423891006728 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1423891006729 Flavoprotein; Region: Flavoprotein; pfam02441 1423891006730 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1423891006731 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1423891006732 G1 box; other site 1423891006733 GTP/Mg2+ binding site [chemical binding]; other site 1423891006734 G2 box; other site 1423891006735 Switch I region; other site 1423891006736 G3 box; other site 1423891006737 Switch II region; other site 1423891006738 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1423891006739 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1423891006740 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 1423891006741 putative active site [active] 1423891006742 catalytic site [active] 1423891006743 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 1423891006744 putative active site [active] 1423891006745 catalytic site [active] 1423891006746 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 1423891006747 putative catalytic site [active] 1423891006748 putative metal binding site [ion binding]; other site 1423891006749 putative phosphate binding site [ion binding]; other site 1423891006750 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1423891006751 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 1423891006752 NAD(P) binding site [chemical binding]; other site 1423891006753 catalytic residues [active] 1423891006754 Predicted membrane protein [Function unknown]; Region: COG3714 1423891006755 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1423891006756 Ligand Binding Site [chemical binding]; other site 1423891006757 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 1423891006758 putative FMN binding site [chemical binding]; other site 1423891006759 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1423891006760 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1423891006761 active site 1423891006762 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1423891006763 catalytic core [active] 1423891006764 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 1423891006765 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1423891006766 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1423891006767 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1423891006768 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1423891006769 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1423891006770 Walker A/P-loop; other site 1423891006771 ATP binding site [chemical binding]; other site 1423891006772 Q-loop/lid; other site 1423891006773 ABC transporter signature motif; other site 1423891006774 Walker B; other site 1423891006775 D-loop; other site 1423891006776 H-loop/switch region; other site 1423891006777 Glucokinase [Carbohydrate transport and metabolism]; Region: Glk; COG0837 1423891006778 glucokinase, proteobacterial type; Region: glk; TIGR00749 1423891006779 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1423891006780 active site 1423891006781 dimer interfaces [polypeptide binding]; other site 1423891006782 catalytic residues [active] 1423891006783 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 1423891006784 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 1423891006785 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1423891006786 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1423891006787 putative NAD(P) binding site [chemical binding]; other site 1423891006788 epoxyqueuosine reductase; Region: TIGR00276 1423891006789 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1423891006790 HEAT repeat; Region: HEAT; pfam02985 1423891006791 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1423891006792 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1423891006793 C-terminal domain interface [polypeptide binding]; other site 1423891006794 GSH binding site (G-site) [chemical binding]; other site 1423891006795 dimer interface [polypeptide binding]; other site 1423891006796 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 1423891006797 N-terminal domain interface [polypeptide binding]; other site 1423891006798 dimer interface [polypeptide binding]; other site 1423891006799 substrate binding pocket (H-site) [chemical binding]; other site 1423891006800 Undecaprenyl pyrophosphate phosphatase [Lipid transport and metabolism]; Region: BacA; COG1968 1423891006801 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1423891006802 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 1423891006803 putative NAD(P) binding site [chemical binding]; other site 1423891006804 active site 1423891006805 GTP-binding protein LepA; Provisional; Region: PRK05433 1423891006806 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1423891006807 G1 box; other site 1423891006808 putative GEF interaction site [polypeptide binding]; other site 1423891006809 GTP/Mg2+ binding site [chemical binding]; other site 1423891006810 Switch I region; other site 1423891006811 G2 box; other site 1423891006812 G3 box; other site 1423891006813 Switch II region; other site 1423891006814 G4 box; other site 1423891006815 G5 box; other site 1423891006816 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1423891006817 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1423891006818 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1423891006819 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1423891006820 GIY-YIG motif/motif A; other site 1423891006821 putative active site [active] 1423891006822 putative metal binding site [ion binding]; other site 1423891006823 Uncharacterized protein conserved in bacteria [Posttranslational modification, protein turnover, chaperones]; Region: COG3526 1423891006824 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 1423891006825 RmuC family; Region: RmuC; pfam02646 1423891006826 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1423891006827 active site 1423891006828 catalytic residues [active] 1423891006829 metal binding site [ion binding]; metal-binding site 1423891006830 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1423891006831 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1423891006832 putative active site [active] 1423891006833 substrate binding site [chemical binding]; other site 1423891006834 putative cosubstrate binding site; other site 1423891006835 catalytic site [active] 1423891006836 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1423891006837 substrate binding site [chemical binding]; other site 1423891006838 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1423891006839 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1423891006840 dimerization interface 3.5A [polypeptide binding]; other site 1423891006841 active site 1423891006842 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1423891006843 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1423891006844 metal binding site [ion binding]; metal-binding site 1423891006845 dimer interface [polypeptide binding]; other site 1423891006846 Predicted transglutaminase-like cysteine proteinase [General function prediction only]; Region: COG3672 1423891006847 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1423891006848 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1423891006849 trimer interface [polypeptide binding]; other site 1423891006850 active site 1423891006851 substrate binding site [chemical binding]; other site 1423891006852 CoA binding site [chemical binding]; other site 1423891006853 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1423891006854 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 1423891006855 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 1423891006856 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1423891006857 homohexameric interface [polypeptide binding]; other site 1423891006858 feedback inhibition sensing region; other site 1423891006859 nucleotide binding site [chemical binding]; other site 1423891006860 N-acetyl-L-glutamate binding site [chemical binding]; other site 1423891006861 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1423891006862 G1 box; other site 1423891006863 GTP/Mg2+ binding site [chemical binding]; other site 1423891006864 Switch I region; other site 1423891006865 G2 box; other site 1423891006866 G3 box; other site 1423891006867 Switch II region; other site 1423891006868 G4 box; other site 1423891006869 G5 box; other site 1423891006870 membrane protein insertase; Provisional; Region: PRK01318 1423891006871 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1423891006872 ribonuclease P; Reviewed; Region: rnpA; PRK01313 1423891006873 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1423891006874 homotrimer interaction site [polypeptide binding]; other site 1423891006875 putative active site [active] 1423891006876 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1423891006877 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1423891006878 putative substrate translocation pore; other site 1423891006879 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1423891006880 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1423891006881 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1423891006882 DNA-binding site [nucleotide binding]; DNA binding site 1423891006883 FCD domain; Region: FCD; pfam07729 1423891006884 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1423891006885 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 1423891006886 NAD(P) binding site [chemical binding]; other site 1423891006887 catalytic residues [active] 1423891006888 catalytic residues [active] 1423891006889 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345 1423891006890 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1423891006891 putative NAD(P) binding site [chemical binding]; other site 1423891006892 active site 1423891006893 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1423891006894 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 1423891006895 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1423891006896 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891006897 dimer interface [polypeptide binding]; other site 1423891006898 conserved gate region; other site 1423891006899 putative PBP binding loops; other site 1423891006900 ABC-ATPase subunit interface; other site 1423891006901 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1423891006902 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891006903 dimer interface [polypeptide binding]; other site 1423891006904 conserved gate region; other site 1423891006905 putative PBP binding loops; other site 1423891006906 ABC-ATPase subunit interface; other site 1423891006907 amidase; Provisional; Region: PRK07042 1423891006908 Amidase; Region: Amidase; cl11426 1423891006909 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1423891006910 DNA polymerase III subunit epsilon; Validated; Region: PRK09182 1423891006911 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1423891006912 active site 1423891006913 catalytic site [active] 1423891006914 substrate binding site [chemical binding]; other site 1423891006915 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1423891006916 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1423891006917 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1423891006918 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1423891006919 metal binding site [ion binding]; metal-binding site 1423891006920 active site 1423891006921 I-site; other site 1423891006922 glutathionine S-transferase; Provisional; Region: PRK10542 1423891006923 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1423891006924 C-terminal domain interface [polypeptide binding]; other site 1423891006925 GSH binding site (G-site) [chemical binding]; other site 1423891006926 dimer interface [polypeptide binding]; other site 1423891006927 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1423891006928 dimer interface [polypeptide binding]; other site 1423891006929 N-terminal domain interface [polypeptide binding]; other site 1423891006930 substrate binding pocket (H-site) [chemical binding]; other site 1423891006931 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 1423891006932 dimer interface [polypeptide binding]; other site 1423891006933 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 1423891006934 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1423891006935 N-terminal plug; other site 1423891006936 ligand-binding site [chemical binding]; other site 1423891006937 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1423891006938 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1423891006939 Bacterial transcriptional regulator; Region: IclR; pfam01614 1423891006940 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 1423891006941 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1423891006942 putative ligand binding site [chemical binding]; other site 1423891006943 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1423891006944 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1423891006945 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1423891006946 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1423891006947 TM-ABC transporter signature motif; other site 1423891006948 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1423891006949 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1423891006950 TM-ABC transporter signature motif; other site 1423891006951 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1423891006952 homotrimer interaction site [polypeptide binding]; other site 1423891006953 putative active site [active] 1423891006954 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 1423891006955 TMAO/DMSO reductase; Reviewed; Region: PRK05363 1423891006956 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1423891006957 Moco binding site; other site 1423891006958 metal coordination site [ion binding]; other site 1423891006959 Predicted esterase [General function prediction only]; Region: COG0400 1423891006960 putative hydrolase; Provisional; Region: PRK11460 1423891006961 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1423891006962 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1423891006963 structural tetrad; other site 1423891006964 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1423891006965 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1423891006966 P-loop, Walker A motif; other site 1423891006967 Base recognition motif; other site 1423891006968 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1423891006969 Creatinine amidohydrolase; Region: Creatininase; pfam02633 1423891006970 MarR family; Region: MarR_2; cl17246 1423891006971 transcriptional regulator SlyA; Provisional; Region: PRK03573 1423891006972 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1423891006973 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1423891006974 DNA binding site [nucleotide binding] 1423891006975 domain linker motif; other site 1423891006976 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 1423891006977 putative dimerization interface [polypeptide binding]; other site 1423891006978 putative ligand binding site [chemical binding]; other site 1423891006979 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 1423891006980 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1423891006981 putative ligand binding site [chemical binding]; other site 1423891006982 NAD binding site [chemical binding]; other site 1423891006983 catalytic site [active] 1423891006984 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1423891006985 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1423891006986 catalytic triad [active] 1423891006987 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 1423891006988 classical (c) SDRs; Region: SDR_c; cd05233 1423891006989 NAD(P) binding site [chemical binding]; other site 1423891006990 active site 1423891006991 PAS fold; Region: PAS_7; pfam12860 1423891006992 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1423891006993 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1423891006994 metal binding site [ion binding]; metal-binding site 1423891006995 active site 1423891006996 I-site; other site 1423891006997 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1423891006998 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1423891006999 Beta-lactamase; Region: Beta-lactamase; pfam00144 1423891007000 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 1423891007001 Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835 1423891007002 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1423891007003 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1423891007004 ligand binding site [chemical binding]; other site 1423891007005 homodimer interface [polypeptide binding]; other site 1423891007006 NAD(P) binding site [chemical binding]; other site 1423891007007 trimer interface B [polypeptide binding]; other site 1423891007008 trimer interface A [polypeptide binding]; other site 1423891007009 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1423891007010 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1423891007011 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1423891007012 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 1423891007013 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1423891007014 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 1423891007015 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1423891007016 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1423891007017 motif II; other site 1423891007018 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1423891007019 putative active site [active] 1423891007020 putative catalytic site [active] 1423891007021 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 1423891007022 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1423891007023 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 1423891007024 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1423891007025 TPR motif; other site 1423891007026 binding surface 1423891007027 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1423891007028 binding surface 1423891007029 TPR motif; other site 1423891007030 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1423891007031 binding surface 1423891007032 TPR motif; other site 1423891007033 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891007034 dimer interface [polypeptide binding]; other site 1423891007035 conserved gate region; other site 1423891007036 ABC-ATPase subunit interface; other site 1423891007037 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1423891007038 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1423891007039 ABC transporter signature motif; other site 1423891007040 Walker B; other site 1423891007041 D-loop; other site 1423891007042 H-loop/switch region; other site 1423891007043 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1423891007044 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1423891007045 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1423891007046 choline dehydrogenase; Validated; Region: PRK02106 1423891007047 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1423891007048 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1423891007049 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1423891007050 TM-ABC transporter signature motif; other site 1423891007051 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1423891007052 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1423891007053 TM-ABC transporter signature motif; other site 1423891007054 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1423891007055 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1423891007056 Walker A/P-loop; other site 1423891007057 ATP binding site [chemical binding]; other site 1423891007058 Q-loop/lid; other site 1423891007059 ABC transporter signature motif; other site 1423891007060 Walker B; other site 1423891007061 D-loop; other site 1423891007062 H-loop/switch region; other site 1423891007063 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1423891007064 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1423891007065 Walker A/P-loop; other site 1423891007066 ATP binding site [chemical binding]; other site 1423891007067 Q-loop/lid; other site 1423891007068 ABC transporter signature motif; other site 1423891007069 Walker B; other site 1423891007070 D-loop; other site 1423891007071 H-loop/switch region; other site 1423891007072 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1423891007073 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 1423891007074 putative ligand binding site [chemical binding]; other site 1423891007075 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1423891007076 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1423891007077 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1423891007078 dimerization interface [polypeptide binding]; other site 1423891007079 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1423891007080 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1423891007081 AsnC family; Region: AsnC_trans_reg; pfam01037 1423891007082 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1423891007083 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1423891007084 substrate binding pocket [chemical binding]; other site 1423891007085 membrane-bound complex binding site; other site 1423891007086 hinge residues; other site 1423891007087 D-aminopeptidase; Reviewed; Region: PRK13128 1423891007088 Beta-lactamase; Region: Beta-lactamase; pfam00144 1423891007089 D-aminopeptidase, domain B; Region: DAP_B; pfam07930 1423891007090 D-aminopeptidase, domain C; Region: DAP_C; pfam07932 1423891007091 thiamine pyrophosphate protein; Validated; Region: PRK08199 1423891007092 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1423891007093 PYR/PP interface [polypeptide binding]; other site 1423891007094 dimer interface [polypeptide binding]; other site 1423891007095 TPP binding site [chemical binding]; other site 1423891007096 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1423891007097 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1423891007098 TPP-binding site [chemical binding]; other site 1423891007099 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1423891007100 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1423891007101 DNA-binding site [nucleotide binding]; DNA binding site 1423891007102 FCD domain; Region: FCD; pfam07729 1423891007103 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 1423891007104 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1423891007105 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 1423891007106 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 1423891007107 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 1423891007108 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 1423891007109 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1423891007110 active site 1423891007111 intersubunit interface [polypeptide binding]; other site 1423891007112 catalytic residue [active] 1423891007113 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 1423891007114 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1423891007115 putative ligand binding site [chemical binding]; other site 1423891007116 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1423891007117 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1423891007118 Walker A/P-loop; other site 1423891007119 ATP binding site [chemical binding]; other site 1423891007120 Q-loop/lid; other site 1423891007121 ABC transporter signature motif; other site 1423891007122 Walker B; other site 1423891007123 D-loop; other site 1423891007124 H-loop/switch region; other site 1423891007125 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1423891007126 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1423891007127 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1423891007128 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1423891007129 TM-ABC transporter signature motif; other site 1423891007130 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1423891007131 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1423891007132 homodimer interface [polypeptide binding]; other site 1423891007133 substrate-cofactor binding pocket; other site 1423891007134 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1423891007135 catalytic residue [active] 1423891007136 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3758 1423891007137 urocanate hydratase; Provisional; Region: PRK05414 1423891007138 N-formylglutamate amidohydrolase; Region: hutG_amidohyd; TIGR02017 1423891007139 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1423891007140 active sites [active] 1423891007141 tetramer interface [polypeptide binding]; other site 1423891007142 imidazolonepropionase; Validated; Region: PRK09356 1423891007143 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1423891007144 active site 1423891007145 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 1423891007146 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 1423891007147 active site 1423891007148 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 1423891007149 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1423891007150 DNA-binding site [nucleotide binding]; DNA binding site 1423891007151 UTRA domain; Region: UTRA; pfam07702 1423891007152 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 1423891007153 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1423891007154 inhibitor-cofactor binding pocket; inhibition site 1423891007155 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1423891007156 catalytic residue [active] 1423891007157 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1423891007158 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1423891007159 non-specific DNA binding site [nucleotide binding]; other site 1423891007160 salt bridge; other site 1423891007161 sequence-specific DNA binding site [nucleotide binding]; other site 1423891007162 Cupin domain; Region: Cupin_2; pfam07883 1423891007163 D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409 1423891007164 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1423891007165 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1423891007166 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1423891007167 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1423891007168 active site 1423891007169 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1423891007170 dimer interface [polypeptide binding]; other site 1423891007171 substrate binding site [chemical binding]; other site 1423891007172 catalytic residues [active] 1423891007173 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1423891007174 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1423891007175 putative DNA binding site [nucleotide binding]; other site 1423891007176 putative Zn2+ binding site [ion binding]; other site 1423891007177 AsnC family; Region: AsnC_trans_reg; pfam01037 1423891007178 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1423891007179 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 1423891007180 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1423891007181 phosphate binding site [ion binding]; other site 1423891007182 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1423891007183 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1423891007184 putative molybdopterin cofactor binding site [chemical binding]; other site 1423891007185 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1423891007186 putative molybdopterin cofactor binding site; other site 1423891007187 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1423891007188 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1423891007189 HlyD family secretion protein; Region: HlyD_3; pfam13437 1423891007190 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1423891007191 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1423891007192 HlyD family secretion protein; Region: HlyD_3; pfam13437 1423891007193 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1423891007194 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1423891007195 DNA-binding site [nucleotide binding]; DNA binding site 1423891007196 UTRA domain; Region: UTRA; pfam07702 1423891007197 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1423891007198 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1423891007199 dimer interface [polypeptide binding]; other site 1423891007200 active site 1423891007201 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1423891007202 dimer interface [polypeptide binding]; other site 1423891007203 active site 1423891007204 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1423891007205 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1423891007206 active site 1423891007207 dimer interface [polypeptide binding]; other site 1423891007208 hypothetical protein; Provisional; Region: PRK02947 1423891007209 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1423891007210 putative active site [active] 1423891007211 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1423891007212 aldehyde dehydrogenase family 7 member; Region: PLN02315 1423891007213 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 1423891007214 tetrameric interface [polypeptide binding]; other site 1423891007215 NAD binding site [chemical binding]; other site 1423891007216 catalytic residues [active] 1423891007217 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1423891007218 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1423891007219 putative Zn2+ binding site [ion binding]; other site 1423891007220 putative DNA binding site [nucleotide binding]; other site 1423891007221 dimerization interface [polypeptide binding]; other site 1423891007222 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1423891007223 dimerization interface [polypeptide binding]; other site 1423891007224 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1423891007225 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1423891007226 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1423891007227 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1423891007228 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1423891007229 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1423891007230 RNA binding site [nucleotide binding]; other site 1423891007231 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1423891007232 dimerization interface [polypeptide binding]; other site 1423891007233 putative DNA binding site [nucleotide binding]; other site 1423891007234 putative Zn2+ binding site [ion binding]; other site 1423891007235 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1423891007236 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1423891007237 FMN binding site [chemical binding]; other site 1423891007238 active site 1423891007239 substrate binding site [chemical binding]; other site 1423891007240 catalytic residue [active] 1423891007241 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1423891007242 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1423891007243 AsnC family; Region: AsnC_trans_reg; pfam01037 1423891007244 Arginase family; Region: Arginase; cd09989 1423891007245 agmatinase; Region: agmatinase; TIGR01230 1423891007246 active site 1423891007247 Mn binding site [ion binding]; other site 1423891007248 oligomer interface [polypeptide binding]; other site 1423891007249 ornithine cyclodeaminase; Validated; Region: PRK07589 1423891007250 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1423891007251 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1423891007252 apolar tunnel; other site 1423891007253 heme binding site [chemical binding]; other site 1423891007254 dimerization interface [polypeptide binding]; other site 1423891007255 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 1423891007256 putative deacylase active site [active] 1423891007257 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1423891007258 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1423891007259 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1423891007260 catalytic residues [active] 1423891007261 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 1423891007262 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1423891007263 tartrate dehydrogenase; Region: TTC; TIGR02089 1423891007264 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1423891007265 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1423891007266 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1423891007267 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1423891007268 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1423891007269 DNA binding site [nucleotide binding] 1423891007270 active site 1423891007271 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1423891007272 putative substrate translocation pore; other site 1423891007273 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1423891007274 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1423891007275 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1423891007276 MarR family; Region: MarR; pfam01047 1423891007277 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1423891007278 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1423891007279 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1423891007280 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1423891007281 substrate binding site [chemical binding]; other site 1423891007282 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1423891007283 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1423891007284 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1423891007285 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1423891007286 active site 1423891007287 Zn binding site [ion binding]; other site 1423891007288 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1423891007289 MgtE intracellular N domain; Region: MgtE_N; pfam03448 1423891007290 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1423891007291 Divalent cation transporter; Region: MgtE; pfam01769 1423891007292 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1423891007293 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1423891007294 G1 box; other site 1423891007295 putative GEF interaction site [polypeptide binding]; other site 1423891007296 GTP/Mg2+ binding site [chemical binding]; other site 1423891007297 Switch I region; other site 1423891007298 G2 box; other site 1423891007299 G3 box; other site 1423891007300 Switch II region; other site 1423891007301 G4 box; other site 1423891007302 G5 box; other site 1423891007303 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1423891007304 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1423891007305 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1423891007306 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1423891007307 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1423891007308 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1423891007309 AMP binding site [chemical binding]; other site 1423891007310 metal binding site [ion binding]; metal-binding site 1423891007311 active site 1423891007312 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1423891007313 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1423891007314 intersubunit interface [polypeptide binding]; other site 1423891007315 active site 1423891007316 zinc binding site [ion binding]; other site 1423891007317 Na+ binding site [ion binding]; other site 1423891007318 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1423891007319 triosephosphate isomerase; Provisional; Region: PRK14565 1423891007320 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1423891007321 substrate binding site [chemical binding]; other site 1423891007322 dimer interface [polypeptide binding]; other site 1423891007323 catalytic triad [active] 1423891007324 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1423891007325 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1423891007326 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1423891007327 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1423891007328 PCI domain; Region: PCI; cl02111 1423891007329 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1423891007330 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1423891007331 glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369 1423891007332 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1423891007333 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1423891007334 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 1423891007335 putative N- and C-terminal domain interface [polypeptide binding]; other site 1423891007336 putative active site [active] 1423891007337 putative xylulose binding site [chemical binding]; other site 1423891007338 MgATP binding site [chemical binding]; other site 1423891007339 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1423891007340 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1423891007341 Walker A/P-loop; other site 1423891007342 ATP binding site [chemical binding]; other site 1423891007343 Q-loop/lid; other site 1423891007344 ABC transporter signature motif; other site 1423891007345 Walker B; other site 1423891007346 D-loop; other site 1423891007347 H-loop/switch region; other site 1423891007348 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1423891007349 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1423891007350 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1423891007351 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1423891007352 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1423891007353 ligand binding site [chemical binding]; other site 1423891007354 dimerization interface [polypeptide binding]; other site 1423891007355 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1423891007356 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1423891007357 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1423891007358 hypothetical protein; Validated; Region: PRK08238 1423891007359 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1423891007360 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 1423891007361 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1423891007362 FAD binding domain; Region: FAD_binding_4; pfam01565 1423891007363 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 1423891007364 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1423891007365 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1423891007366 NAD(P) binding site [chemical binding]; other site 1423891007367 active site 1423891007368 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 1423891007369 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1423891007370 inhibitor-cofactor binding pocket; inhibition site 1423891007371 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1423891007372 catalytic residue [active] 1423891007373 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1423891007374 Protein of unknown function DUF91; Region: DUF91; cl00709 1423891007375 Uncharacterized conserved protein [Function unknown]; Region: COG3586 1423891007376 Protein of unknown function DUF45; Region: DUF45; pfam01863 1423891007377 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1423891007378 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1423891007379 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1423891007380 ATP binding site [chemical binding]; other site 1423891007381 putative Mg++ binding site [ion binding]; other site 1423891007382 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1423891007383 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 1423891007384 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1423891007385 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1423891007386 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1423891007387 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1423891007388 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1423891007389 Uncharacterized phage-associated protein [Function unknown]; Region: GepA; COG3600 1423891007390 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1423891007391 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1423891007392 FMN binding site [chemical binding]; other site 1423891007393 substrate binding site [chemical binding]; other site 1423891007394 putative catalytic residue [active] 1423891007395 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 1423891007396 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1423891007397 ATP binding site [chemical binding]; other site 1423891007398 putative Mg++ binding site [ion binding]; other site 1423891007399 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1423891007400 nucleotide binding region [chemical binding]; other site 1423891007401 ATP-binding site [chemical binding]; other site 1423891007402 DEAD/H associated; Region: DEAD_assoc; pfam08494 1423891007403 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 1423891007404 putative active site [active] 1423891007405 putative metal binding site [ion binding]; other site 1423891007406 conserved hypothetical protein; Region: alph_Pro_TM; TIGR02186 1423891007407 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1423891007408 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1423891007409 Sel1-like repeats; Region: SEL1; smart00671 1423891007410 Sel1-like repeats; Region: SEL1; smart00671 1423891007411 Sel1-like repeats; Region: SEL1; smart00671 1423891007412 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1423891007413 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 1423891007414 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1423891007415 DNA binding residues [nucleotide binding] 1423891007416 putative dimer interface [polypeptide binding]; other site 1423891007417 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 1423891007418 camphor resistance protein CrcB; Provisional; Region: PRK14225 1423891007419 camphor resistance protein CrcB; Provisional; Region: PRK14233 1423891007420 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1423891007421 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1423891007422 HlyD family secretion protein; Region: HlyD_3; pfam13437 1423891007423 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1423891007424 mannonate dehydratase; Region: uxuA; TIGR00695 1423891007425 mannonate dehydratase; Provisional; Region: PRK03906 1423891007426 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1423891007427 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1423891007428 DNA-binding site [nucleotide binding]; DNA binding site 1423891007429 FCD domain; Region: FCD; pfam07729 1423891007430 glucuronate isomerase; Reviewed; Region: PRK02925 1423891007431 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1423891007432 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1423891007433 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1423891007434 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1423891007435 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 1423891007436 hypothetical protein; Provisional; Region: PRK11622 1423891007437 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1423891007438 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1423891007439 Walker A/P-loop; other site 1423891007440 ATP binding site [chemical binding]; other site 1423891007441 Q-loop/lid; other site 1423891007442 ABC transporter signature motif; other site 1423891007443 Walker B; other site 1423891007444 D-loop; other site 1423891007445 H-loop/switch region; other site 1423891007446 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1423891007447 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1423891007448 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1423891007449 nickel responsive regulator; Provisional; Region: PRK02967 1423891007450 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1423891007451 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 1423891007452 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1423891007453 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 1423891007454 substrate binding site [chemical binding]; other site 1423891007455 nickel transporter permease NikB; Provisional; Region: PRK10352 1423891007456 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891007457 dimer interface [polypeptide binding]; other site 1423891007458 conserved gate region; other site 1423891007459 putative PBP binding loops; other site 1423891007460 ABC-ATPase subunit interface; other site 1423891007461 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 1423891007462 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891007463 dimer interface [polypeptide binding]; other site 1423891007464 conserved gate region; other site 1423891007465 putative PBP binding loops; other site 1423891007466 ABC-ATPase subunit interface; other site 1423891007467 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 1423891007468 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1423891007469 Walker A/P-loop; other site 1423891007470 ATP binding site [chemical binding]; other site 1423891007471 Q-loop/lid; other site 1423891007472 ABC transporter signature motif; other site 1423891007473 Walker B; other site 1423891007474 D-loop; other site 1423891007475 H-loop/switch region; other site 1423891007476 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1423891007477 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1423891007478 active site 1423891007479 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1423891007480 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1423891007481 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1423891007482 putative dimerization interface [polypeptide binding]; other site 1423891007483 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1423891007484 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1423891007485 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 1423891007486 FAD binding site [chemical binding]; other site 1423891007487 substrate binding site [chemical binding]; other site 1423891007488 catalytic residues [active] 1423891007489 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1423891007490 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1423891007491 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1423891007492 dimer interface [polypeptide binding]; other site 1423891007493 active site 1423891007494 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1423891007495 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1423891007496 substrate binding site [chemical binding]; other site 1423891007497 oxyanion hole (OAH) forming residues; other site 1423891007498 trimer interface [polypeptide binding]; other site 1423891007499 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1423891007500 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1423891007501 Predicted transcriptional regulator [Transcription]; Region: COG2932 1423891007502 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1423891007503 Catalytic site [active] 1423891007504 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 1423891007505 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 1423891007506 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1423891007507 active site 1423891007508 nucleotide binding site [chemical binding]; other site 1423891007509 HIGH motif; other site 1423891007510 KMSKS motif; other site 1423891007511 tellurite resistance protein terB; Region: terB; cd07176 1423891007512 putative metal binding site [ion binding]; other site 1423891007513 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1423891007514 active site clefts [active] 1423891007515 zinc binding site [ion binding]; other site 1423891007516 dimer interface [polypeptide binding]; other site 1423891007517 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1423891007518 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 1423891007519 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1423891007520 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891007521 dimer interface [polypeptide binding]; other site 1423891007522 conserved gate region; other site 1423891007523 putative PBP binding loops; other site 1423891007524 ABC-ATPase subunit interface; other site 1423891007525 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1423891007526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891007527 dimer interface [polypeptide binding]; other site 1423891007528 conserved gate region; other site 1423891007529 putative PBP binding loops; other site 1423891007530 ABC-ATPase subunit interface; other site 1423891007531 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1423891007532 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1423891007533 Walker A/P-loop; other site 1423891007534 ATP binding site [chemical binding]; other site 1423891007535 Q-loop/lid; other site 1423891007536 ABC transporter signature motif; other site 1423891007537 Walker B; other site 1423891007538 D-loop; other site 1423891007539 H-loop/switch region; other site 1423891007540 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1423891007541 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1423891007542 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1423891007543 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 1423891007544 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1423891007545 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1423891007546 homodimer interface [polypeptide binding]; other site 1423891007547 NADP binding site [chemical binding]; other site 1423891007548 substrate binding site [chemical binding]; other site 1423891007549 phosphogluconate dehydratase; Validated; Region: PRK09054 1423891007550 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1423891007551 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1423891007552 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1423891007553 putative active site [active] 1423891007554 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1423891007555 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1423891007556 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1423891007557 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345 1423891007558 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1423891007559 putative NAD(P) binding site [chemical binding]; other site 1423891007560 active site 1423891007561 drug efflux system protein MdtG; Provisional; Region: PRK09874 1423891007562 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1423891007563 putative substrate translocation pore; other site 1423891007564 Predicted membrane protein [Function unknown]; Region: COG4541 1423891007565 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1423891007566 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1423891007567 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1423891007568 putative DNA binding site [nucleotide binding]; other site 1423891007569 putative Zn2+ binding site [ion binding]; other site 1423891007570 AsnC family; Region: AsnC_trans_reg; pfam01037 1423891007571 Hint domain; Region: Hint_2; pfam13403 1423891007572 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1423891007573 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1423891007574 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1423891007575 hypothetical protein; Reviewed; Region: PRK12275 1423891007576 four helix bundle protein; Region: TIGR02436 1423891007577 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1423891007578 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1423891007579 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1423891007580 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1423891007581 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1423891007582 dimerization interface [polypeptide binding]; other site 1423891007583 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1423891007584 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1423891007585 generic binding surface II; other site 1423891007586 generic binding surface I; other site 1423891007587 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 1423891007588 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1423891007589 RNA methyltransferase, RsmE family; Region: TIGR00046 1423891007590 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1423891007591 MarR family; Region: MarR_2; pfam12802 1423891007592 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1423891007593 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1423891007594 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1423891007595 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1423891007596 HlyD family secretion protein; Region: HlyD_3; pfam13437 1423891007597 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 1423891007598 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1423891007599 putative ligand binding residues [chemical binding]; other site 1423891007600 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1423891007601 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1423891007602 ABC-ATPase subunit interface; other site 1423891007603 dimer interface [polypeptide binding]; other site 1423891007604 putative PBP binding regions; other site 1423891007605 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1423891007606 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1423891007607 Walker A/P-loop; other site 1423891007608 ATP binding site [chemical binding]; other site 1423891007609 Q-loop/lid; other site 1423891007610 ABC transporter signature motif; other site 1423891007611 Walker B; other site 1423891007612 D-loop; other site 1423891007613 H-loop/switch region; other site 1423891007614 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1423891007615 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1423891007616 EamA-like transporter family; Region: EamA; pfam00892 1423891007617 BA14K-like protein; Region: BA14K; pfam07886 1423891007618 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1423891007619 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 1423891007620 putative active site [active] 1423891007621 metal binding site [ion binding]; metal-binding site 1423891007622 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1423891007623 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1423891007624 Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931 1423891007625 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1423891007626 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1423891007627 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1423891007628 putative active site [active] 1423891007629 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1423891007630 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1423891007631 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1423891007632 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 1423891007633 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1423891007634 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1423891007635 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1423891007636 lipoyl attachment site [posttranslational modification]; other site 1423891007637 glycine dehydrogenase; Provisional; Region: PRK05367 1423891007638 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1423891007639 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1423891007640 catalytic residue [active] 1423891007641 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1423891007642 tetramer interface [polypeptide binding]; other site 1423891007643 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1423891007644 catalytic residue [active] 1423891007645 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1423891007646 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1423891007647 putative DNA binding site [nucleotide binding]; other site 1423891007648 putative Zn2+ binding site [ion binding]; other site 1423891007649 AsnC family; Region: AsnC_trans_reg; pfam01037 1423891007650 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 1423891007651 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1423891007652 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1423891007653 Glutamate binding site [chemical binding]; other site 1423891007654 NAD binding site [chemical binding]; other site 1423891007655 catalytic residues [active] 1423891007656 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 1423891007657 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1423891007658 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1423891007659 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891007660 dimer interface [polypeptide binding]; other site 1423891007661 conserved gate region; other site 1423891007662 putative PBP binding loops; other site 1423891007663 ABC-ATPase subunit interface; other site 1423891007664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891007665 dimer interface [polypeptide binding]; other site 1423891007666 conserved gate region; other site 1423891007667 putative PBP binding loops; other site 1423891007668 ABC-ATPase subunit interface; other site 1423891007669 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1423891007670 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1423891007671 Walker A/P-loop; other site 1423891007672 ATP binding site [chemical binding]; other site 1423891007673 Q-loop/lid; other site 1423891007674 ABC transporter signature motif; other site 1423891007675 Walker B; other site 1423891007676 D-loop; other site 1423891007677 H-loop/switch region; other site 1423891007678 TOBE domain; Region: TOBE_2; pfam08402 1423891007679 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1423891007680 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 1423891007681 active site 1423891007682 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 1423891007683 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1423891007684 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1423891007685 TPP-binding site [chemical binding]; other site 1423891007686 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1423891007687 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1423891007688 substrate binding site [chemical binding]; other site 1423891007689 ATP binding site [chemical binding]; other site 1423891007690 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 1423891007691 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1423891007692 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1423891007693 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1423891007694 putative active site [active] 1423891007695 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1423891007696 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1423891007697 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1423891007698 Protein of unknown function (DUF1612); Region: DUF1612; pfam07756 1423891007699 HTH DNA binding domain; Region: HTH_13; pfam11972 1423891007700 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1423891007701 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1423891007702 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1423891007703 dimerization interface [polypeptide binding]; other site 1423891007704 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1423891007705 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1423891007706 dimer interface [polypeptide binding]; other site 1423891007707 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1423891007708 catalytic triad [active] 1423891007709 peroxidatic and resolving cysteines [active] 1423891007710 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 1423891007711 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1423891007712 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1423891007713 metabolite-proton symporter; Region: 2A0106; TIGR00883 1423891007714 putative substrate translocation pore; other site 1423891007715 multicopper oxidase; Provisional; Region: PRK10965 1423891007716 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1423891007717 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1423891007718 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1423891007719 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1423891007720 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1423891007721 E-class dimer interface [polypeptide binding]; other site 1423891007722 P-class dimer interface [polypeptide binding]; other site 1423891007723 active site 1423891007724 Cu2+ binding site [ion binding]; other site 1423891007725 Zn2+ binding site [ion binding]; other site 1423891007726 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1423891007727 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1423891007728 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1423891007729 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1423891007730 Walker A/P-loop; other site 1423891007731 ATP binding site [chemical binding]; other site 1423891007732 Q-loop/lid; other site 1423891007733 ABC transporter signature motif; other site 1423891007734 Walker B; other site 1423891007735 D-loop; other site 1423891007736 H-loop/switch region; other site 1423891007737 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1423891007738 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1423891007739 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1423891007740 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891007741 dimer interface [polypeptide binding]; other site 1423891007742 conserved gate region; other site 1423891007743 putative PBP binding loops; other site 1423891007744 ABC-ATPase subunit interface; other site 1423891007745 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891007746 dimer interface [polypeptide binding]; other site 1423891007747 conserved gate region; other site 1423891007748 putative PBP binding loops; other site 1423891007749 ABC-ATPase subunit interface; other site 1423891007750 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1423891007751 lumazine synthase and riboflavin synthase; involved in the riboflavin (vitamin B2) biosynthetic pathway; Region: Lumazine_synthase-like; cl00317 1423891007752 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1423891007753 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1423891007754 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891007755 dimer interface [polypeptide binding]; other site 1423891007756 conserved gate region; other site 1423891007757 putative PBP binding loops; other site 1423891007758 ABC-ATPase subunit interface; other site 1423891007759 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1423891007760 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1423891007761 Walker A/P-loop; other site 1423891007762 ATP binding site [chemical binding]; other site 1423891007763 Q-loop/lid; other site 1423891007764 ABC transporter signature motif; other site 1423891007765 Walker B; other site 1423891007766 D-loop; other site 1423891007767 H-loop/switch region; other site 1423891007768 TOBE domain; Region: TOBE_2; pfam08402 1423891007769 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1423891007770 putative transporter; Provisional; Region: PRK10504 1423891007771 putative substrate translocation pore; other site 1423891007772 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1423891007773 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1423891007774 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1423891007775 S-adenosylmethionine binding site [chemical binding]; other site 1423891007776 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1423891007777 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1423891007778 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891007779 dimer interface [polypeptide binding]; other site 1423891007780 conserved gate region; other site 1423891007781 putative PBP binding loops; other site 1423891007782 ABC-ATPase subunit interface; other site 1423891007783 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1423891007784 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1423891007785 substrate binding pocket [chemical binding]; other site 1423891007786 membrane-bound complex binding site; other site 1423891007787 hinge residues; other site 1423891007788 5-oxoprolinase; Region: PLN02666 1423891007789 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1423891007790 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1423891007791 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1423891007792 Predicted transcription regulator, contains HTH domain (MarR family) [Transcription]; Region: COG5631 1423891007793 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1423891007794 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1423891007795 Walker A/P-loop; other site 1423891007796 ATP binding site [chemical binding]; other site 1423891007797 Q-loop/lid; other site 1423891007798 ABC transporter signature motif; other site 1423891007799 Walker B; other site 1423891007800 D-loop; other site 1423891007801 H-loop/switch region; other site 1423891007802 ABC-type enterochelin transport system, permease component [Inorganic ion transport and metabolism]; Region: CeuC; COG4605 1423891007803 ABC-ATPase subunit interface; other site 1423891007804 dimer interface [polypeptide binding]; other site 1423891007805 putative PBP binding regions; other site 1423891007806 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1423891007807 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1423891007808 ABC-ATPase subunit interface; other site 1423891007809 dimer interface [polypeptide binding]; other site 1423891007810 putative PBP binding regions; other site 1423891007811 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1423891007812 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1423891007813 putative ligand binding residues [chemical binding]; other site 1423891007814 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 1423891007815 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1423891007816 NAD binding site [chemical binding]; other site 1423891007817 catalytic residues [active] 1423891007818 aminotransferase; Provisional; Region: PRK13356 1423891007819 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1423891007820 homodimer interface [polypeptide binding]; other site 1423891007821 substrate-cofactor binding pocket; other site 1423891007822 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1423891007823 catalytic residue [active] 1423891007824 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1423891007825 EamA-like transporter family; Region: EamA; pfam00892 1423891007826 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1423891007827 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1423891007828 nucleoside/Zn binding site; other site 1423891007829 dimer interface [polypeptide binding]; other site 1423891007830 catalytic motif [active] 1423891007831 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1423891007832 TrkA-C domain; Region: TrkA_C; pfam02080 1423891007833 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1423891007834 TrkA-C domain; Region: TrkA_C; pfam02080 1423891007835 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1423891007836 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1423891007837 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1423891007838 Walker A/P-loop; other site 1423891007839 ATP binding site [chemical binding]; other site 1423891007840 Q-loop/lid; other site 1423891007841 ABC transporter signature motif; other site 1423891007842 Walker B; other site 1423891007843 D-loop; other site 1423891007844 H-loop/switch region; other site 1423891007845 TOBE domain; Region: TOBE_2; pfam08402 1423891007846 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1423891007847 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891007848 dimer interface [polypeptide binding]; other site 1423891007849 conserved gate region; other site 1423891007850 ABC-ATPase subunit interface; other site 1423891007851 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1423891007852 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1423891007853 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1423891007854 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 1423891007855 active site 1423891007856 dimer interface [polypeptide binding]; other site 1423891007857 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1423891007858 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1423891007859 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1423891007860 active site 1423891007861 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1423891007862 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1423891007863 Walker A/P-loop; other site 1423891007864 ATP binding site [chemical binding]; other site 1423891007865 Q-loop/lid; other site 1423891007866 ABC transporter signature motif; other site 1423891007867 Walker B; other site 1423891007868 D-loop; other site 1423891007869 H-loop/switch region; other site 1423891007870 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1423891007871 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1423891007872 Walker A/P-loop; other site 1423891007873 ATP binding site [chemical binding]; other site 1423891007874 Q-loop/lid; other site 1423891007875 ABC transporter signature motif; other site 1423891007876 Walker B; other site 1423891007877 D-loop; other site 1423891007878 H-loop/switch region; other site 1423891007879 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1423891007880 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1423891007881 TM-ABC transporter signature motif; other site 1423891007882 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1423891007883 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1423891007884 TM-ABC transporter signature motif; other site 1423891007885 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1423891007886 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1423891007887 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 1423891007888 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 1423891007889 heterodimer interface [polypeptide binding]; other site 1423891007890 active site 1423891007891 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1423891007892 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 1423891007893 active site 1423891007894 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 1423891007895 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1423891007896 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1423891007897 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1423891007898 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1423891007899 dimerization interface [polypeptide binding]; other site 1423891007900 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 1423891007901 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1423891007902 hypothetical protein; Provisional; Region: PRK07236 1423891007903 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 1423891007904 Cupin domain; Region: Cupin_2; cl17218 1423891007905 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1423891007906 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1423891007907 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1423891007908 Bacterial transcriptional regulator; Region: IclR; pfam01614 1423891007909 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 1423891007910 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1423891007911 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1423891007912 active site 1423891007913 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1423891007914 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1423891007915 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1423891007916 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1423891007917 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1423891007918 active site 1423891007919 catalytic site [active] 1423891007920 substrate binding site [chemical binding]; other site 1423891007921 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 1423891007922 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1423891007923 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1423891007924 metal binding site [ion binding]; metal-binding site 1423891007925 active site 1423891007926 I-site; other site 1423891007927 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 1423891007928 DNA polymerase IV; Provisional; Region: PRK02794 1423891007929 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1423891007930 active site 1423891007931 DNA binding site [nucleotide binding] 1423891007932 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 1423891007933 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1423891007934 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1423891007935 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1423891007936 active site 1423891007937 phosphorylation site [posttranslational modification] 1423891007938 intermolecular recognition site; other site 1423891007939 dimerization interface [polypeptide binding]; other site 1423891007940 response regulator PleD; Reviewed; Region: pleD; PRK09581 1423891007941 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1423891007942 active site 1423891007943 phosphorylation site [posttranslational modification] 1423891007944 intermolecular recognition site; other site 1423891007945 dimerization interface [polypeptide binding]; other site 1423891007946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1423891007947 active site 1423891007948 phosphorylation site [posttranslational modification] 1423891007949 intermolecular recognition site; other site 1423891007950 dimerization interface [polypeptide binding]; other site 1423891007951 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1423891007952 metal binding site [ion binding]; metal-binding site 1423891007953 active site 1423891007954 I-site; other site 1423891007955 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1423891007956 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1423891007957 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1423891007958 putative substrate translocation pore; other site 1423891007959 hypothetical protein; Provisional; Region: PRK05978 1423891007960 ribonuclease R; Region: RNase_R; TIGR02063 1423891007961 RNB domain; Region: RNB; pfam00773 1423891007962 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1423891007963 RNA binding site [nucleotide binding]; other site 1423891007964 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1423891007965 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1423891007966 active site 1423891007967 interdomain interaction site; other site 1423891007968 putative metal-binding site [ion binding]; other site 1423891007969 nucleotide binding site [chemical binding]; other site 1423891007970 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1423891007971 domain I; other site 1423891007972 DNA binding groove [nucleotide binding] 1423891007973 phosphate binding site [ion binding]; other site 1423891007974 domain II; other site 1423891007975 domain III; other site 1423891007976 nucleotide binding site [chemical binding]; other site 1423891007977 catalytic site [active] 1423891007978 domain IV; other site 1423891007979 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1423891007980 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1423891007981 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1423891007982 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1423891007983 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1423891007984 DNA protecting protein DprA; Region: dprA; TIGR00732 1423891007985 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1423891007986 dihydroorotase; Validated; Region: PRK09059 1423891007987 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1423891007988 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1423891007989 active site 1423891007990 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1423891007991 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1423891007992 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1423891007993 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1423891007994 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1423891007995 active site 1423891007996 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 1423891007997 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1423891007998 metal-dependent hydrolase; Provisional; Region: PRK00685 1423891007999 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1423891008000 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1423891008001 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1423891008002 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1423891008003 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1423891008004 Mg2+ binding site [ion binding]; other site 1423891008005 G-X-G motif; other site 1423891008006 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1423891008007 anchoring element; other site 1423891008008 dimer interface [polypeptide binding]; other site 1423891008009 ATP binding site [chemical binding]; other site 1423891008010 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1423891008011 active site 1423891008012 metal binding site [ion binding]; metal-binding site 1423891008013 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1423891008014 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1423891008015 EamA-like transporter family; Region: EamA; pfam00892 1423891008016 lipoate-protein ligase B; Provisional; Region: PRK14341 1423891008017 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1423891008018 PAS domain; Region: PAS_9; pfam13426 1423891008019 putative active site [active] 1423891008020 heme pocket [chemical binding]; other site 1423891008021 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1423891008022 PAS fold; Region: PAS_3; pfam08447 1423891008023 putative active site [active] 1423891008024 heme pocket [chemical binding]; other site 1423891008025 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1423891008026 HWE histidine kinase; Region: HWE_HK; pfam07536 1423891008027 BA14K-like protein; Region: BA14K; pfam07886 1423891008028 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 1423891008029 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 1423891008030 Predicted integral membrane protein [Function unknown]; Region: COG0392 1423891008031 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1423891008032 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1423891008033 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1423891008034 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1423891008035 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 1423891008036 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1423891008037 Substrate binding site; other site 1423891008038 Mg++ binding site; other site 1423891008039 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1423891008040 active site 1423891008041 substrate binding site [chemical binding]; other site 1423891008042 CoA binding site [chemical binding]; other site 1423891008043 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1423891008044 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1423891008045 glutaminase active site [active] 1423891008046 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1423891008047 dimer interface [polypeptide binding]; other site 1423891008048 active site 1423891008049 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1423891008050 dimer interface [polypeptide binding]; other site 1423891008051 active site 1423891008052 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 1423891008053 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1423891008054 generic binding surface II; other site 1423891008055 ssDNA binding site; other site 1423891008056 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1423891008057 ATP binding site [chemical binding]; other site 1423891008058 putative Mg++ binding site [ion binding]; other site 1423891008059 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1423891008060 nucleotide binding region [chemical binding]; other site 1423891008061 ATP-binding site [chemical binding]; other site 1423891008062 Uncharacterized conserved protein [Function unknown]; Region: COG2938 1423891008063 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1423891008064 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1423891008065 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1423891008066 ATP binding site [chemical binding]; other site 1423891008067 putative Mg++ binding site [ion binding]; other site 1423891008068 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1423891008069 nucleotide binding region [chemical binding]; other site 1423891008070 ATP-binding site [chemical binding]; other site 1423891008071 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1423891008072 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1423891008073 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 1423891008074 active site 1423891008075 metal binding site [ion binding]; metal-binding site 1423891008076 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1423891008077 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1423891008078 catalytic residues [active] 1423891008079 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1423891008080 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1423891008081 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 1423891008082 Uncharacterized conserved protein [Function unknown]; Region: COG3785 1423891008083 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494 1423891008084 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1423891008085 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1423891008086 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1423891008087 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1423891008088 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1423891008089 NADP binding site [chemical binding]; other site 1423891008090 dimer interface [polypeptide binding]; other site 1423891008091 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1423891008092 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1423891008093 Walker A/P-loop; other site 1423891008094 ATP binding site [chemical binding]; other site 1423891008095 Q-loop/lid; other site 1423891008096 ABC transporter signature motif; other site 1423891008097 Walker B; other site 1423891008098 D-loop; other site 1423891008099 H-loop/switch region; other site 1423891008100 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1423891008101 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1423891008102 TM-ABC transporter signature motif; other site 1423891008103 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1423891008104 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1423891008105 TM-ABC transporter signature motif; other site 1423891008106 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1423891008107 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1423891008108 putative ligand binding site [chemical binding]; other site 1423891008109 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 1423891008110 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1423891008111 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1423891008112 FeS/SAM binding site; other site 1423891008113 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1423891008114 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1423891008115 heme binding site [chemical binding]; other site 1423891008116 ferroxidase pore; other site 1423891008117 ferroxidase diiron center [ion binding]; other site 1423891008118 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1423891008119 iron-responsive transcriptional regulator; Reviewed; Region: rirA; PRK11920 1423891008120 Predicted transcriptional regulator [Transcription]; Region: COG1959 1423891008121 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1423891008122 putative deacylase active site [active] 1423891008123 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1423891008124 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1423891008125 Transposase; Region: HTH_Tnp_1; pfam01527 1423891008126 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1423891008127 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1423891008128 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1423891008129 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1423891008130 yecA family protein; Region: ygfB_yecA; TIGR02292 1423891008131 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1423891008132 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1423891008133 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1423891008134 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 1423891008135 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 1423891008136 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1423891008137 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1423891008138 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1423891008139 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1423891008140 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1423891008141 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1423891008142 active site 1423891008143 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1423891008144 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1423891008145 NAD binding site [chemical binding]; other site 1423891008146 homodimer interface [polypeptide binding]; other site 1423891008147 active site 1423891008148 substrate binding site [chemical binding]; other site 1423891008149 Predicted integral membrane protein [Function unknown]; Region: COG5455 1423891008150 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1423891008151 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1423891008152 peptide binding site [polypeptide binding]; other site 1423891008153 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1423891008154 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1423891008155 peptide binding site [polypeptide binding]; other site 1423891008156 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1423891008157 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891008158 dimer interface [polypeptide binding]; other site 1423891008159 conserved gate region; other site 1423891008160 putative PBP binding loops; other site 1423891008161 ABC-ATPase subunit interface; other site 1423891008162 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1423891008163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891008164 dimer interface [polypeptide binding]; other site 1423891008165 conserved gate region; other site 1423891008166 ABC-ATPase subunit interface; other site 1423891008167 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 1423891008168 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1423891008169 Walker A/P-loop; other site 1423891008170 ATP binding site [chemical binding]; other site 1423891008171 Q-loop/lid; other site 1423891008172 ABC transporter signature motif; other site 1423891008173 Walker B; other site 1423891008174 D-loop; other site 1423891008175 H-loop/switch region; other site 1423891008176 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1423891008177 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1423891008178 Walker A/P-loop; other site 1423891008179 ATP binding site [chemical binding]; other site 1423891008180 Q-loop/lid; other site 1423891008181 ABC transporter signature motif; other site 1423891008182 Walker B; other site 1423891008183 D-loop; other site 1423891008184 H-loop/switch region; other site 1423891008185 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1423891008186 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 1423891008187 benzoate transport; Region: 2A0115; TIGR00895 1423891008188 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1423891008189 putative substrate translocation pore; other site 1423891008190 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 1423891008191 homodimer interface [polypeptide binding]; other site 1423891008192 homotetramer interface [polypeptide binding]; other site 1423891008193 active site pocket [active] 1423891008194 cleavage site 1423891008195 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1423891008196 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1423891008197 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1423891008198 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1423891008199 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1423891008200 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1423891008201 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1423891008202 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1423891008203 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1423891008204 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1423891008205 alpha subunit interface [polypeptide binding]; other site 1423891008206 TPP binding site [chemical binding]; other site 1423891008207 heterodimer interface [polypeptide binding]; other site 1423891008208 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1423891008209 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573 1423891008210 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1423891008211 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1423891008212 tetramer interface [polypeptide binding]; other site 1423891008213 TPP-binding site [chemical binding]; other site 1423891008214 heterodimer interface [polypeptide binding]; other site 1423891008215 phosphorylation loop region [posttranslational modification] 1423891008216 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1423891008217 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1423891008218 Walker A/P-loop; other site 1423891008219 ATP binding site [chemical binding]; other site 1423891008220 Q-loop/lid; other site 1423891008221 ABC transporter signature motif; other site 1423891008222 Walker B; other site 1423891008223 D-loop; other site 1423891008224 H-loop/switch region; other site 1423891008225 TOBE domain; Region: TOBE_2; pfam08402 1423891008226 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1423891008227 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1423891008228 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1423891008229 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891008230 dimer interface [polypeptide binding]; other site 1423891008231 conserved gate region; other site 1423891008232 putative PBP binding loops; other site 1423891008233 ABC-ATPase subunit interface; other site 1423891008234 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1423891008235 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891008236 dimer interface [polypeptide binding]; other site 1423891008237 conserved gate region; other site 1423891008238 putative PBP binding loops; other site 1423891008239 ABC-ATPase subunit interface; other site 1423891008240 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1423891008241 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1423891008242 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1423891008243 nucleotide binding site [chemical binding]; other site 1423891008244 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1423891008245 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1423891008246 DNA-binding site [nucleotide binding]; DNA binding site 1423891008247 UTRA domain; Region: UTRA; pfam07702 1423891008248 Predicted outer membrane lipoprotein [Function unknown]; Region: COG4890 1423891008249 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1423891008250 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1423891008251 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1423891008252 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1423891008253 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1423891008254 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1423891008255 Walker A/P-loop; other site 1423891008256 ATP binding site [chemical binding]; other site 1423891008257 Q-loop/lid; other site 1423891008258 ABC transporter signature motif; other site 1423891008259 Walker B; other site 1423891008260 D-loop; other site 1423891008261 H-loop/switch region; other site 1423891008262 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1423891008263 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1423891008264 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1423891008265 Walker A/P-loop; other site 1423891008266 ATP binding site [chemical binding]; other site 1423891008267 Q-loop/lid; other site 1423891008268 ABC transporter signature motif; other site 1423891008269 Walker B; other site 1423891008270 D-loop; other site 1423891008271 H-loop/switch region; other site 1423891008272 Predicted transcriptional regulators [Transcription]; Region: COG1510 1423891008273 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1423891008274 dimerization interface [polypeptide binding]; other site 1423891008275 putative DNA binding site [nucleotide binding]; other site 1423891008276 putative Zn2+ binding site [ion binding]; other site 1423891008277 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12671 1423891008278 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 1423891008279 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12596 1423891008280 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 1423891008281 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1423891008282 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 1423891008283 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 1423891008284 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1423891008285 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1423891008286 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1423891008287 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1423891008288 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1423891008289 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1423891008290 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1423891008291 dimer interface [polypeptide binding]; other site 1423891008292 FMN binding site [chemical binding]; other site 1423891008293 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1423891008294 MPT binding site; other site 1423891008295 trimer interface [polypeptide binding]; other site 1423891008296 biotin synthase; Region: bioB; TIGR00433 1423891008297 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1423891008298 FeS/SAM binding site; other site 1423891008299 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1423891008300 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1423891008301 hypothetical protein; Provisional; Region: PRK07505 1423891008302 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1423891008303 catalytic residue [active] 1423891008304 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1423891008305 AAA domain; Region: AAA_26; pfam13500 1423891008306 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 1423891008307 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1423891008308 inhibitor-cofactor binding pocket; inhibition site 1423891008309 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1423891008310 catalytic residue [active] 1423891008311 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05963 1423891008312 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1423891008313 dimer interface [polypeptide binding]; other site 1423891008314 active site 1423891008315 CoA binding pocket [chemical binding]; other site 1423891008316 Homoserine trans-succinylase [Amino acid transport and metabolism]; Region: MetA; COG1897 1423891008317 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1423891008318 proposed active site lysine [active] 1423891008319 conserved cys residue [active] 1423891008320 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 1423891008321 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 1423891008322 active site 1423891008323 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1423891008324 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1423891008325 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1423891008326 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1423891008327 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1423891008328 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1423891008329 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1423891008330 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1423891008331 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1423891008332 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1423891008333 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1423891008334 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1423891008335 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1423891008336 active site 1423891008337 phosphorylation site [posttranslational modification] 1423891008338 intermolecular recognition site; other site 1423891008339 dimerization interface [polypeptide binding]; other site 1423891008340 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1423891008341 DNA binding site [nucleotide binding] 1423891008342 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1423891008343 HAMP domain; Region: HAMP; pfam00672 1423891008344 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1423891008345 dimer interface [polypeptide binding]; other site 1423891008346 phosphorylation site [posttranslational modification] 1423891008347 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1423891008348 ATP binding site [chemical binding]; other site 1423891008349 Mg2+ binding site [ion binding]; other site 1423891008350 G-X-G motif; other site 1423891008351 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1423891008352 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1423891008353 HlyD family secretion protein; Region: HlyD_3; pfam13437 1423891008354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1423891008355 putative substrate translocation pore; other site 1423891008356 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1423891008357 MarR family; Region: MarR_2; pfam12802 1423891008358 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1423891008359 NMT1/THI5 like; Region: NMT1; pfam09084 1423891008360 substrate binding pocket [chemical binding]; other site 1423891008361 membrane-bound complex binding site; other site 1423891008362 hinge residues; other site 1423891008363 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1423891008364 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1423891008365 Walker A/P-loop; other site 1423891008366 ATP binding site [chemical binding]; other site 1423891008367 Q-loop/lid; other site 1423891008368 ABC transporter signature motif; other site 1423891008369 Walker B; other site 1423891008370 D-loop; other site 1423891008371 H-loop/switch region; other site 1423891008372 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1423891008373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891008374 dimer interface [polypeptide binding]; other site 1423891008375 conserved gate region; other site 1423891008376 putative PBP binding loops; other site 1423891008377 ABC-ATPase subunit interface; other site 1423891008378 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1423891008379 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1423891008380 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1423891008381 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1423891008382 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 1423891008383 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1423891008384 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 1423891008385 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1423891008386 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1423891008387 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1423891008388 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1423891008389 DNA-binding site [nucleotide binding]; DNA binding site 1423891008390 FCD domain; Region: FCD; pfam07729 1423891008391 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 1423891008392 Predicted transporter component [General function prediction only]; Region: COG2391 1423891008393 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1423891008394 dimerization interface [polypeptide binding]; other site 1423891008395 putative DNA binding site [nucleotide binding]; other site 1423891008396 putative Zn2+ binding site [ion binding]; other site 1423891008397 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 1423891008398 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1423891008399 active site 1423891008400 catalytic residues [active] 1423891008401 metal binding site [ion binding]; metal-binding site 1423891008402 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1423891008403 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1423891008404 ligand binding site [chemical binding]; other site 1423891008405 NAD binding site [chemical binding]; other site 1423891008406 tetramer interface [polypeptide binding]; other site 1423891008407 catalytic site [active] 1423891008408 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1423891008409 L-serine binding site [chemical binding]; other site 1423891008410 ACT domain interface; other site 1423891008411 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1423891008412 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1423891008413 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1423891008414 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1423891008415 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_2; cd05973 1423891008416 active site 1423891008417 acyl-activating enzyme (AAE) consensus motif; other site 1423891008418 putative CoA binding site [chemical binding]; other site 1423891008419 AMP binding site [chemical binding]; other site 1423891008420 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 1423891008421 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 1423891008422 NAD binding site [chemical binding]; other site 1423891008423 homodimer interface [polypeptide binding]; other site 1423891008424 homotetramer interface [polypeptide binding]; other site 1423891008425 active site 1423891008426 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 1423891008427 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1423891008428 dimer interface [polypeptide binding]; other site 1423891008429 active site 1423891008430 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1423891008431 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1423891008432 active site 1423891008433 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1423891008434 SelR domain; Region: SelR; pfam01641 1423891008435 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 1423891008436 putative dimerization interface [polypeptide binding]; other site 1423891008437 putative substrate binding pocket [chemical binding]; other site 1423891008438 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1423891008439 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1423891008440 putative substrate translocation pore; other site 1423891008441 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 1423891008442 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1423891008443 N- and C-terminal domain interface [polypeptide binding]; other site 1423891008444 active site 1423891008445 MgATP binding site [chemical binding]; other site 1423891008446 catalytic site [active] 1423891008447 metal binding site [ion binding]; metal-binding site 1423891008448 glycerol binding site [chemical binding]; other site 1423891008449 homotetramer interface [polypeptide binding]; other site 1423891008450 homodimer interface [polypeptide binding]; other site 1423891008451 FBP binding site [chemical binding]; other site 1423891008452 protein IIAGlc interface [polypeptide binding]; other site 1423891008453 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1423891008454 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1423891008455 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1423891008456 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1423891008457 active site 1423891008458 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 1423891008459 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1423891008460 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1423891008461 S-adenosylmethionine binding site [chemical binding]; other site 1423891008462 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 1423891008463 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1423891008464 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1423891008465 extended (e) SDRs; Region: SDR_e; cd08946 1423891008466 NAD(P) binding site [chemical binding]; other site 1423891008467 active site 1423891008468 substrate binding site [chemical binding]; other site 1423891008469 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 1423891008470 glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209 1423891008471 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1423891008472 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1423891008473 catalytic residue [active] 1423891008474 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1423891008475 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1423891008476 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 1423891008477 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1423891008478 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1423891008479 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1423891008480 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1423891008481 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1423891008482 Mg++ binding site [ion binding]; other site 1423891008483 putative catalytic motif [active] 1423891008484 substrate binding site [chemical binding]; other site 1423891008485 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1423891008486 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1423891008487 putative metal binding site; other site 1423891008488 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1423891008489 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1423891008490 putative active site [active] 1423891008491 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 1423891008492 putative trimer interface [polypeptide binding]; other site 1423891008493 putative active site [active] 1423891008494 putative substrate binding site [chemical binding]; other site 1423891008495 putative CoA binding site [chemical binding]; other site 1423891008496 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1423891008497 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 1423891008498 putative ADP-binding pocket [chemical binding]; other site 1423891008499 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1423891008500 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1423891008501 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1423891008502 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1423891008503 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1423891008504 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1423891008505 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1423891008506 NADP-binding site; other site 1423891008507 homotetramer interface [polypeptide binding]; other site 1423891008508 substrate binding site [chemical binding]; other site 1423891008509 homodimer interface [polypeptide binding]; other site 1423891008510 active site 1423891008511 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1423891008512 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1423891008513 NADP binding site [chemical binding]; other site 1423891008514 active site 1423891008515 putative substrate binding site [chemical binding]; other site 1423891008516 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 1423891008517 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1423891008518 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1423891008519 Chain length determinant protein; Region: Wzz; cl15801 1423891008520 AAA domain; Region: AAA_31; pfam13614 1423891008521 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1423891008522 G3 box; other site 1423891008523 Switch II region; other site 1423891008524 G4 box; other site 1423891008525 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1423891008526 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1423891008527 DNA binding residues [nucleotide binding] 1423891008528 dimerization interface [polypeptide binding]; other site 1423891008529 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1423891008530 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1423891008531 ligand binding site [chemical binding]; other site 1423891008532 flexible hinge region; other site 1423891008533 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1423891008534 putative switch regulator; other site 1423891008535 non-specific DNA interactions [nucleotide binding]; other site 1423891008536 DNA binding site [nucleotide binding] 1423891008537 sequence specific DNA binding site [nucleotide binding]; other site 1423891008538 putative cAMP binding site [chemical binding]; other site 1423891008539 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 1423891008540 N-acetylmannosamine kinase; Provisional; Region: PRK05082 1423891008541 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 1423891008542 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1423891008543 putative active site cavity [active] 1423891008544 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1423891008545 nucleotide binding site [chemical binding]; other site 1423891008546 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1423891008547 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1423891008548 DNA-binding site [nucleotide binding]; DNA binding site 1423891008549 FCD domain; Region: FCD; pfam07729 1423891008550 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1423891008551 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1423891008552 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1423891008553 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891008554 dimer interface [polypeptide binding]; other site 1423891008555 conserved gate region; other site 1423891008556 putative PBP binding loops; other site 1423891008557 ABC-ATPase subunit interface; other site 1423891008558 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1423891008559 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891008560 dimer interface [polypeptide binding]; other site 1423891008561 conserved gate region; other site 1423891008562 putative PBP binding loops; other site 1423891008563 ABC-ATPase subunit interface; other site 1423891008564 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1423891008565 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1423891008566 inhibitor site; inhibition site 1423891008567 active site 1423891008568 dimer interface [polypeptide binding]; other site 1423891008569 catalytic residue [active] 1423891008570 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1423891008571 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1423891008572 Walker A/P-loop; other site 1423891008573 ATP binding site [chemical binding]; other site 1423891008574 Q-loop/lid; other site 1423891008575 ABC transporter signature motif; other site 1423891008576 Walker B; other site 1423891008577 D-loop; other site 1423891008578 H-loop/switch region; other site 1423891008579 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1423891008580 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1423891008581 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1423891008582 Walker A/P-loop; other site 1423891008583 ATP binding site [chemical binding]; other site 1423891008584 Q-loop/lid; other site 1423891008585 ABC transporter signature motif; other site 1423891008586 Walker B; other site 1423891008587 D-loop; other site 1423891008588 H-loop/switch region; other site 1423891008589 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1423891008590 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1423891008591 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1423891008592 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1423891008593 Zinc-dependent alcohol dehydrogenases (ADH) and class III ADG (AKA formaldehyde dehydrogenase); Region: liver_ADH_like1; cd08281 1423891008594 NAD binding site [chemical binding]; other site 1423891008595 catalytic Zn binding site [ion binding]; other site 1423891008596 substrate binding site [chemical binding]; other site 1423891008597 structural Zn binding site [ion binding]; other site 1423891008598 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1423891008599 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1423891008600 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1423891008601 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1423891008602 tetramerization interface [polypeptide binding]; other site 1423891008603 NAD(P) binding site [chemical binding]; other site 1423891008604 catalytic residues [active] 1423891008605 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 1423891008606 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1423891008607 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 1423891008608 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1423891008609 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1423891008610 shikimate binding site; other site 1423891008611 NAD(P) binding site [chemical binding]; other site 1423891008612 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1423891008613 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1423891008614 NAD(P) binding site [chemical binding]; other site 1423891008615 active site 1423891008616 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1423891008617 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1423891008618 Walker A/P-loop; other site 1423891008619 ATP binding site [chemical binding]; other site 1423891008620 Q-loop/lid; other site 1423891008621 ABC transporter signature motif; other site 1423891008622 Walker B; other site 1423891008623 D-loop; other site 1423891008624 H-loop/switch region; other site 1423891008625 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1423891008626 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1423891008627 TM-ABC transporter signature motif; other site 1423891008628 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1423891008629 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1423891008630 Walker A/P-loop; other site 1423891008631 ATP binding site [chemical binding]; other site 1423891008632 Q-loop/lid; other site 1423891008633 ABC transporter signature motif; other site 1423891008634 Walker B; other site 1423891008635 D-loop; other site 1423891008636 H-loop/switch region; other site 1423891008637 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1423891008638 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1423891008639 TM-ABC transporter signature motif; other site 1423891008640 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1423891008641 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1423891008642 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1423891008643 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1423891008644 NAD(P) binding site [chemical binding]; other site 1423891008645 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1423891008646 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1423891008647 DNA-binding site [nucleotide binding]; DNA binding site 1423891008648 FCD domain; Region: FCD; pfam07729 1423891008649 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1423891008650 Cytochrome P450; Region: p450; cl12078 1423891008651 acetate kinase; Provisional; Region: PRK07058 1423891008652 propionate/acetate kinase; Provisional; Region: PRK12379 1423891008653 putative phosphoketolase; Provisional; Region: PRK05261 1423891008654 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1423891008655 TPP-binding site; other site 1423891008656 XFP C-terminal domain; Region: XFP_C; pfam09363 1423891008657 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 1423891008658 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1423891008659 Uncharacterized protein probably involved in high-affinity Fe2+ transport [Inorganic ion transport and metabolism]; Region: Tpd; COG3470 1423891008660 GMP synthase; Reviewed; Region: guaA; PRK00074 1423891008661 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1423891008662 AMP/PPi binding site [chemical binding]; other site 1423891008663 candidate oxyanion hole; other site 1423891008664 catalytic triad [active] 1423891008665 potential glutamine specificity residues [chemical binding]; other site 1423891008666 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1423891008667 ATP Binding subdomain [chemical binding]; other site 1423891008668 Ligand Binding sites [chemical binding]; other site 1423891008669 Dimerization subdomain; other site 1423891008670 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06026 1423891008671 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, putative; Region: MTA/SAH-nuc-hyp; TIGR01705 1423891008672 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1423891008673 CoenzymeA binding site [chemical binding]; other site 1423891008674 subunit interaction site [polypeptide binding]; other site 1423891008675 PHB binding site; other site 1423891008676 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 1423891008677 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 1423891008678 Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495 1423891008679 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1423891008680 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1423891008681 tetramer interface [polypeptide binding]; other site 1423891008682 heme binding pocket [chemical binding]; other site 1423891008683 NADPH binding site [chemical binding]; other site 1423891008684 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1423891008685 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1423891008686 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1423891008687 dimerization interface [polypeptide binding]; other site 1423891008688 Cytochrome c [Energy production and conversion]; Region: COG3258 1423891008689 Cytochrome c; Region: Cytochrom_C; pfam00034 1423891008690 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1423891008691 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1423891008692 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1423891008693 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1423891008694 active site 1423891008695 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1423891008696 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 1423891008697 putative ion selectivity filter; other site 1423891008698 putative pore gating glutamate residue; other site 1423891008699 putative H+/Cl- coupling transport residue; other site 1423891008700 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1423891008701 putative active site pocket [active] 1423891008702 cleavage site 1423891008703 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1423891008704 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 1423891008705 active site 1423891008706 substrate binding site [chemical binding]; other site 1423891008707 metal binding site [ion binding]; metal-binding site 1423891008708 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1423891008709 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1423891008710 Substrate binding site; other site 1423891008711 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1423891008712 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1423891008713 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1423891008714 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1423891008715 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1423891008716 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1423891008717 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1423891008718 acid-resistance protein; Provisional; Region: PRK10208 1423891008719 glutaminase; Reviewed; Region: PRK12356 1423891008720 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1423891008721 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 1423891008722 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1423891008723 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 1423891008724 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1423891008725 catalytic residue [active] 1423891008726 Predicted membrane protein [Function unknown]; Region: COG4803 1423891008727 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1423891008728 HlyD family secretion protein; Region: HlyD_3; pfam13437 1423891008729 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1423891008730 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1423891008731 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891008732 dimer interface [polypeptide binding]; other site 1423891008733 conserved gate region; other site 1423891008734 putative PBP binding loops; other site 1423891008735 ABC-ATPase subunit interface; other site 1423891008736 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891008737 dimer interface [polypeptide binding]; other site 1423891008738 conserved gate region; other site 1423891008739 putative PBP binding loops; other site 1423891008740 ABC-ATPase subunit interface; other site 1423891008741 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1423891008742 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1423891008743 Walker A/P-loop; other site 1423891008744 ATP binding site [chemical binding]; other site 1423891008745 Q-loop/lid; other site 1423891008746 ABC transporter signature motif; other site 1423891008747 Walker B; other site 1423891008748 D-loop; other site 1423891008749 H-loop/switch region; other site 1423891008750 TOBE domain; Region: TOBE_2; pfam08402 1423891008751 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1423891008752 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1423891008753 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 1423891008754 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 1423891008755 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1423891008756 Switch I; other site 1423891008757 Switch II; other site 1423891008758 septum formation inhibitor; Reviewed; Region: minC; PRK05177 1423891008759 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1423891008760 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1423891008761 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1423891008762 dimer interface [polypeptide binding]; other site 1423891008763 putative radical transfer pathway; other site 1423891008764 diiron center [ion binding]; other site 1423891008765 tyrosyl radical; other site 1423891008766 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1423891008767 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1423891008768 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1423891008769 active site 1423891008770 dimer interface [polypeptide binding]; other site 1423891008771 catalytic residues [active] 1423891008772 effector binding site; other site 1423891008773 R2 peptide binding site; other site 1423891008774 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1423891008775 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1423891008776 catalytic residues [active] 1423891008777 Transmembrane secretion effector; Region: MFS_3; pfam05977 1423891008778 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1423891008779 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1423891008780 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1423891008781 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1423891008782 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1423891008783 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1423891008784 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1423891008785 Walker A/P-loop; other site 1423891008786 ATP binding site [chemical binding]; other site 1423891008787 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1423891008788 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891008789 dimer interface [polypeptide binding]; other site 1423891008790 conserved gate region; other site 1423891008791 putative PBP binding loops; other site 1423891008792 ABC-ATPase subunit interface; other site 1423891008793 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1423891008794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891008795 dimer interface [polypeptide binding]; other site 1423891008796 conserved gate region; other site 1423891008797 putative PBP binding loops; other site 1423891008798 ABC-ATPase subunit interface; other site 1423891008799 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1423891008800 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1423891008801 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1423891008802 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1423891008803 DNA binding site [nucleotide binding] 1423891008804 domain linker motif; other site 1423891008805 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 1423891008806 ligand binding site [chemical binding]; other site 1423891008807 transcriptional activator FtrB; Provisional; Region: ftrB; PRK09392 1423891008808 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1423891008809 ligand binding site [chemical binding]; other site 1423891008810 flexible hinge region; other site 1423891008811 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 1423891008812 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1423891008813 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1423891008814 putative substrate translocation pore; other site 1423891008815 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1423891008816 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1423891008817 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1423891008818 [4Fe-4S] binding site [ion binding]; other site 1423891008819 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1423891008820 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1423891008821 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1423891008822 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1423891008823 molybdopterin cofactor binding site; other site 1423891008824 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1423891008825 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1423891008826 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 1423891008827 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1423891008828 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1423891008829 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1423891008830 Protein of unknown function (DUF2478); Region: DUF2478; pfam10649 1423891008831 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 1423891008832 Flavoprotein; Region: Flavoprotein; pfam02441 1423891008833 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 1423891008834 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 1423891008835 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1423891008836 Peptidase family U32; Region: Peptidase_U32; pfam01136 1423891008837 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1423891008838 putative protease; Provisional; Region: PRK15447 1423891008839 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1423891008840 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1423891008841 Walker A/P-loop; other site 1423891008842 ATP binding site [chemical binding]; other site 1423891008843 Q-loop/lid; other site 1423891008844 ABC transporter signature motif; other site 1423891008845 Walker B; other site 1423891008846 D-loop; other site 1423891008847 H-loop/switch region; other site 1423891008848 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1423891008849 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891008850 dimer interface [polypeptide binding]; other site 1423891008851 conserved gate region; other site 1423891008852 putative PBP binding loops; other site 1423891008853 ABC-ATPase subunit interface; other site 1423891008854 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1423891008855 NMT1-like family; Region: NMT1_2; pfam13379 1423891008856 Uncharacterized protein involved in response to NO [Inorganic ion transport and metabolism]; Region: NnrS; COG3213 1423891008857 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 1423891008858 pseudoazurin; Region: pseudoazurin; TIGR02375 1423891008859 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1423891008860 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1423891008861 ligand binding site [chemical binding]; other site 1423891008862 flexible hinge region; other site 1423891008863 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1423891008864 putative switch regulator; other site 1423891008865 non-specific DNA interactions [nucleotide binding]; other site 1423891008866 DNA binding site [nucleotide binding] 1423891008867 sequence specific DNA binding site [nucleotide binding]; other site 1423891008868 putative cAMP binding site [chemical binding]; other site 1423891008869 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 1423891008870 ApbE family; Region: ApbE; pfam02424 1423891008871 Predicted lipoprotein involved in nitrous oxide reduction [Energy production and conversion]; Region: NosL; COG4314 1423891008872 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1423891008873 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1423891008874 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1423891008875 Walker A/P-loop; other site 1423891008876 ATP binding site [chemical binding]; other site 1423891008877 Q-loop/lid; other site 1423891008878 ABC transporter signature motif; other site 1423891008879 Walker B; other site 1423891008880 D-loop; other site 1423891008881 H-loop/switch region; other site 1423891008882 Domain present in carbohydrate binding proteins and sugar hydrolses; Region: CASH; smart00722 1423891008883 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 1423891008884 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 1423891008885 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1423891008886 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 1423891008887 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 1423891008888 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1423891008889 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1423891008890 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1423891008891 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1423891008892 RES domain; Region: RES; smart00953 1423891008893 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 1423891008894 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 1423891008895 N- and C-terminal domain interface [polypeptide binding]; other site 1423891008896 active site 1423891008897 MgATP binding site [chemical binding]; other site 1423891008898 catalytic site [active] 1423891008899 metal binding site [ion binding]; metal-binding site 1423891008900 carbohydrate binding site [chemical binding]; other site 1423891008901 putative homodimer interface [polypeptide binding]; other site 1423891008902 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1423891008903 classical (c) SDRs; Region: SDR_c; cd05233 1423891008904 NAD(P) binding site [chemical binding]; other site 1423891008905 active site 1423891008906 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1423891008907 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1423891008908 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1423891008909 TM-ABC transporter signature motif; other site 1423891008910 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1423891008911 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1423891008912 Walker A/P-loop; other site 1423891008913 ATP binding site [chemical binding]; other site 1423891008914 Q-loop/lid; other site 1423891008915 ABC transporter signature motif; other site 1423891008916 Walker B; other site 1423891008917 D-loop; other site 1423891008918 H-loop/switch region; other site 1423891008919 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 1423891008920 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1423891008921 putative ligand binding site [chemical binding]; other site 1423891008922 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1423891008923 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1423891008924 DNA binding site [nucleotide binding] 1423891008925 domain linker motif; other site 1423891008926 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1423891008927 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1423891008928 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1423891008929 ligand binding site [chemical binding]; other site 1423891008930 flexible hinge region; other site 1423891008931 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1423891008932 putative switch regulator; other site 1423891008933 non-specific DNA interactions [nucleotide binding]; other site 1423891008934 DNA binding site [nucleotide binding] 1423891008935 sequence specific DNA binding site [nucleotide binding]; other site 1423891008936 putative cAMP binding site [chemical binding]; other site 1423891008937 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1423891008938 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1423891008939 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 1423891008940 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1423891008941 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1423891008942 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1423891008943 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1423891008944 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 1423891008945 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1423891008946 metal ion-dependent adhesion site (MIDAS); other site 1423891008947 MoxR-like ATPases [General function prediction only]; Region: COG0714 1423891008948 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1423891008949 Walker A motif; other site 1423891008950 ATP binding site [chemical binding]; other site 1423891008951 Walker B motif; other site 1423891008952 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1423891008953 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1423891008954 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 1423891008955 Binuclear center (active site) [active] 1423891008956 K-pathway; other site 1423891008957 Putative proton exit pathway; other site 1423891008958 Cytochrome c; Region: Cytochrom_C; pfam00034 1423891008959 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 1423891008960 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 1423891008961 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1423891008962 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 1423891008963 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 1423891008964 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1423891008965 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1423891008966 inhibitor site; inhibition site 1423891008967 active site 1423891008968 dimer interface [polypeptide binding]; other site 1423891008969 catalytic residue [active] 1423891008970 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1423891008971 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1423891008972 DNA-binding site [nucleotide binding]; DNA binding site 1423891008973 FCD domain; Region: FCD; pfam07729 1423891008974 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1423891008975 EamA-like transporter family; Region: EamA; pfam00892 1423891008976 EamA-like transporter family; Region: EamA; cl17759 1423891008977 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1423891008978 GAF domain; Region: GAF; pfam01590 1423891008979 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1423891008980 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1423891008981 metal binding site [ion binding]; metal-binding site 1423891008982 active site 1423891008983 I-site; other site 1423891008984 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1423891008985 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1423891008986 Flavodoxin; Region: Flavodoxin_1; pfam00258 1423891008987 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like2; cd06201 1423891008988 FAD binding pocket [chemical binding]; other site 1423891008989 FAD binding motif [chemical binding]; other site 1423891008990 catalytic residues [active] 1423891008991 NAD binding pocket [chemical binding]; other site 1423891008992 phosphate binding motif [ion binding]; other site 1423891008993 beta-alpha-beta structure motif; other site 1423891008994 Uncharacterized conserved protein [Function unknown]; Region: COG5591 1423891008995 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1423891008996 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1423891008997 active site 1423891008998 phosphorylation site [posttranslational modification] 1423891008999 intermolecular recognition site; other site 1423891009000 dimerization interface [polypeptide binding]; other site 1423891009001 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1423891009002 DNA binding site [nucleotide binding] 1423891009003 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1423891009004 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1423891009005 potential catalytic triad [active] 1423891009006 conserved cys residue [active] 1423891009007 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg7; cd04786 1423891009008 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1423891009009 DNA binding residues [nucleotide binding] 1423891009010 putative dimer interface [polypeptide binding]; other site 1423891009011 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1423891009012 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 1423891009013 putative active site [active] 1423891009014 putative FMN binding site [chemical binding]; other site 1423891009015 putative substrate binding site [chemical binding]; other site 1423891009016 putative catalytic residue [active] 1423891009017 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 1423891009018 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1423891009019 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1423891009020 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1423891009021 enoyl-CoA hydratase; Provisional; Region: PRK08138 1423891009022 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1423891009023 substrate binding site [chemical binding]; other site 1423891009024 oxyanion hole (OAH) forming residues; other site 1423891009025 trimer interface [polypeptide binding]; other site 1423891009026 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1423891009027 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1423891009028 Bacterial transcriptional regulator; Region: IclR; pfam01614 1423891009029 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1423891009030 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1423891009031 active site 1423891009032 benzoate transport; Region: 2A0115; TIGR00895 1423891009033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1423891009034 putative substrate translocation pore; other site 1423891009035 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1423891009036 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1423891009037 ATP binding site [chemical binding]; other site 1423891009038 Mg2+ binding site [ion binding]; other site 1423891009039 G-X-G motif; other site 1423891009040 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1423891009041 ATP binding site [chemical binding]; other site 1423891009042 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1423891009043 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 1423891009044 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1423891009045 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 1423891009046 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1423891009047 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1423891009048 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 1423891009049 putative acyl-acceptor binding pocket; other site 1423891009050 Domain of unknown function (DUF4170); Region: DUF4170; pfam13773 1423891009051 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1423891009052 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1423891009053 active site 1423891009054 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1423891009055 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 1423891009056 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1423891009057 TrkA-N domain; Region: TrkA_N; pfam02254 1423891009058 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1423891009059 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1423891009060 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1423891009061 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1423891009062 S-adenosylmethionine binding site [chemical binding]; other site 1423891009063 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1423891009064 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1423891009065 RNA binding surface [nucleotide binding]; other site 1423891009066 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1423891009067 active site 1423891009068 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1423891009069 nucleoside/Zn binding site; other site 1423891009070 dimer interface [polypeptide binding]; other site 1423891009071 catalytic motif [active] 1423891009072 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1423891009073 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 1423891009074 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1423891009075 active site 1423891009076 HIGH motif; other site 1423891009077 nucleotide binding site [chemical binding]; other site 1423891009078 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1423891009079 active site 1423891009080 KMSKS motif; other site 1423891009081 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1423891009082 tRNA binding surface [nucleotide binding]; other site 1423891009083 anticodon binding site; other site 1423891009084 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1423891009085 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1423891009086 active site 1423891009087 Riboflavin kinase; Region: Flavokinase; smart00904 1423891009088 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1423891009089 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 1423891009090 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1423891009091 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1423891009092 oligomerisation interface [polypeptide binding]; other site 1423891009093 mobile loop; other site 1423891009094 roof hairpin; other site 1423891009095 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1423891009096 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1423891009097 ring oligomerisation interface [polypeptide binding]; other site 1423891009098 ATP/Mg binding site [chemical binding]; other site 1423891009099 stacking interactions; other site 1423891009100 hinge regions; other site 1423891009101 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1423891009102 Class II fumarases; Region: Fumarase_classII; cd01362 1423891009103 active site 1423891009104 tetramer interface [polypeptide binding]; other site 1423891009105 Predicted membrane protein [Function unknown]; Region: COG2259 1423891009106 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1423891009107 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1423891009108 putative substrate translocation pore; other site 1423891009109 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583 1423891009110 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1423891009111 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295 1423891009112 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1423891009113 motif 1; other site 1423891009114 dimer interface [polypeptide binding]; other site 1423891009115 active site 1423891009116 motif 2; other site 1423891009117 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1423891009118 active site 1423891009119 motif 3; other site 1423891009120 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 1423891009121 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1423891009122 dimer interface [polypeptide binding]; other site 1423891009123 motif 1; other site 1423891009124 motif 2; other site 1423891009125 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1423891009126 active site 1423891009127 motif 3; other site 1423891009128 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1423891009129 anticodon binding site; other site 1423891009130 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1423891009131 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1423891009132 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1423891009133 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1423891009134 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1423891009135 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1423891009136 active site 1423891009137 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 1423891009138 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1423891009139 Cysteine-rich domain; Region: CCG; pfam02754 1423891009140 Cysteine-rich domain; Region: CCG; pfam02754 1423891009141 FAD binding domain; Region: FAD_binding_4; pfam01565 1423891009142 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 1423891009143 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 1423891009144 FAD binding domain; Region: FAD_binding_4; pfam01565 1423891009145 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1423891009146 transcriptional activator TtdR; Provisional; Region: PRK09801 1423891009147 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1423891009148 putative effector binding pocket; other site 1423891009149 dimerization interface [polypeptide binding]; other site 1423891009150 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 1423891009151 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1423891009152 DNA-binding site [nucleotide binding]; DNA binding site 1423891009153 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1423891009154 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841 1423891009155 Cytochrome c2 [Energy production and conversion]; Region: COG3474 1423891009156 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1423891009157 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1423891009158 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1423891009159 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1423891009160 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1423891009161 Uncharacterized conserved protein [Function unknown]; Region: COG3777 1423891009162 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1423891009163 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1423891009164 active site 2 [active] 1423891009165 active site 1 [active] 1423891009166 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1423891009167 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1423891009168 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1423891009169 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1423891009170 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 1423891009171 putative dimerization interface [polypeptide binding]; other site 1423891009172 FliP family; Region: FliP; cl00593 1423891009173 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 1423891009174 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 1423891009175 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 1423891009176 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1423891009177 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1423891009178 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK06005 1423891009179 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 1423891009180 flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506 1423891009181 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1423891009182 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790 1423891009183 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782 1423891009184 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1423891009185 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1423891009186 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003 1423891009187 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1423891009188 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1423891009189 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 1423891009190 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1423891009191 Metal-binding active site; metal-binding site 1423891009192 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1423891009193 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1423891009194 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1423891009195 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1423891009196 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 1423891009197 putative NAD(P) binding site [chemical binding]; other site 1423891009198 active site 1423891009199 putative substrate binding site [chemical binding]; other site 1423891009200 putative aldolase; Validated; Region: PRK08130 1423891009201 intersubunit interface [polypeptide binding]; other site 1423891009202 active site 1423891009203 Zn2+ binding site [ion binding]; other site 1423891009204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1423891009205 D-galactonate transporter; Region: 2A0114; TIGR00893 1423891009206 putative substrate translocation pore; other site 1423891009207 Transposase; Region: HTH_Tnp_1; cl17663 1423891009208 Helix-turn-helix domain; Region: HTH_18; pfam12833 1423891009209 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1423891009210 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1423891009211 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1423891009212 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807 1423891009213 putative active site [active] 1423891009214 YdjC motif; other site 1423891009215 Mg binding site [ion binding]; other site 1423891009216 putative homodimer interface [polypeptide binding]; other site 1423891009217 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1423891009218 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1423891009219 Ligand binding site; other site 1423891009220 Putative Catalytic site; other site 1423891009221 DXD motif; other site 1423891009222 Peptidase family M48; Region: Peptidase_M48; cl12018 1423891009223 GtrA-like protein; Region: GtrA; pfam04138 1423891009224 PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389 1423891009225 active site 1423891009226 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002 1423891009227 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1423891009228 Walker A motif; other site 1423891009229 ATP binding site [chemical binding]; other site 1423891009230 Walker B motif; other site 1423891009231 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642 1423891009232 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1423891009233 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1423891009234 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 1423891009235 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 1423891009236 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1423891009237 flagellar motor protein MotA; Validated; Region: PRK09110 1423891009238 Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868 1423891009239 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1423891009240 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 1423891009241 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1423891009242 FliG C-terminal domain; Region: FliG_C; pfam01706 1423891009243 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377 1423891009244 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1423891009245 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1423891009246 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1423891009247 DNA binding residues [nucleotide binding] 1423891009248 dimerization interface [polypeptide binding]; other site 1423891009249 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1423891009250 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1423891009251 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 1423891009252 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1423891009253 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1423891009254 HlyD family secretion protein; Region: HlyD_3; pfam13437 1423891009255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1423891009256 putative substrate translocation pore; other site 1423891009257 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1423891009258 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1423891009259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891009260 dimer interface [polypeptide binding]; other site 1423891009261 conserved gate region; other site 1423891009262 putative PBP binding loops; other site 1423891009263 ABC-ATPase subunit interface; other site 1423891009264 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1423891009265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1423891009266 dimer interface [polypeptide binding]; other site 1423891009267 conserved gate region; other site 1423891009268 putative PBP binding loops; other site 1423891009269 ABC-ATPase subunit interface; other site 1423891009270 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1423891009271 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1423891009272 Walker A/P-loop; other site 1423891009273 ATP binding site [chemical binding]; other site 1423891009274 Q-loop/lid; other site 1423891009275 ABC transporter signature motif; other site 1423891009276 Walker B; other site 1423891009277 D-loop; other site 1423891009278 H-loop/switch region; other site 1423891009279 TOBE domain; Region: TOBE_2; pfam08402 1423891009280 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG0362 1423891009281 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1423891009282 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1423891009283 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1423891009284 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1423891009285 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1423891009286 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1423891009287 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1423891009288 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1423891009289 active site 1423891009290 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 1423891009291 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1423891009292 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1423891009293 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1423891009294 Chain length determinant protein; Region: Wzz; pfam02706 1423891009295 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1423891009296 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 1423891009297 dimer interface [polypeptide binding]; other site 1423891009298 active site 1423891009299 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1423891009300 catalytic residues [active] 1423891009301 substrate binding site [chemical binding]; other site 1423891009302 amidase; Provisional; Region: PRK08310 1423891009303 indole-3-acetamide amidohydrolase; Region: PLN02722 1423891009304 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1423891009305 LysR family transcriptional regulator; Provisional; Region: PRK14997 1423891009306 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1423891009307 putative effector binding pocket; other site 1423891009308 dimerization interface [polypeptide binding]; other site 1423891009309 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 1423891009310 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215