-- dump date   	20140619_010849
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1407053000001	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
1407053000002	substrate binding site [chemical binding]; other site
1407053000003	active site
1407053000004	Predicted membrane protein [Function unknown]; Region: COG1981
1407053000005	transcription termination factor Rho; Provisional; Region: rho; PRK09376
1407053000006	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
1407053000007	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
1407053000008	RNA binding site [nucleotide binding]; other site
1407053000009	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
1407053000010	multimer interface [polypeptide binding]; other site
1407053000011	Walker A motif; other site
1407053000012	ATP binding site [chemical binding]; other site
1407053000013	Walker B motif; other site
1407053000014	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
1407053000015	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
1407053000016	catalytic residues [active]
1407053000017	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
1407053000018	Predicted GTPase [General function prediction only]; Region: ThdF; COG0486
1407053000019	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
1407053000020	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
1407053000021	trmE is a tRNA modification GTPase; Region: trmE; cd04164
1407053000022	G1 box; other site
1407053000023	G1 box; other site
1407053000024	GTP/Mg2+ binding site [chemical binding]; other site
1407053000025	GTP/Mg2+ binding site [chemical binding]; other site
1407053000026	Switch I region; other site
1407053000027	Switch I region; other site
1407053000028	G2 box; other site
1407053000029	G2 box; other site
1407053000030	Switch II region; other site
1407053000031	G3 box; other site
1407053000032	G4 box; other site
1407053000033	G5 box; other site
1407053000034	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
1407053000035	Flavin-dependent tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Cell cycle control, cell division, chromosome partitioning]; Region: GidA; COG0445
1407053000036	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
1407053000037	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
1407053000038	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
1407053000039	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1407053000040	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1407053000041	P-loop; other site
1407053000042	Magnesium ion binding site [ion binding]; other site
1407053000043	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1407053000044	Magnesium ion binding site [ion binding]; other site
1407053000045	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
1407053000046	ParB-like nuclease domain; Region: ParB; smart00470
1407053000047	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585
1407053000048	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1407053000049	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1407053000050	Walker A/P-loop; other site
1407053000051	ATP binding site [chemical binding]; other site
1407053000052	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1407053000053	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
1407053000054	TM-ABC transporter signature motif; other site
1407053000055	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
1407053000056	zinc binding site [ion binding]; other site
1407053000057	putative ligand binding site [chemical binding]; other site
1407053000058	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
1407053000059	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
1407053000060	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1407053000061	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1407053000062	DNA binding site [nucleotide binding]
1407053000063	domain linker motif; other site
1407053000064	Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289
1407053000065	putative dimerization interface [polypeptide binding]; other site
1407053000066	putative ligand binding site [chemical binding]; other site
1407053000067	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1407053000068	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1407053000069	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1407053000070	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
1407053000071	Coenzyme A transferase; Region: CoA_trans; smart00882
1407053000072	Coenzyme A transferase; Region: CoA_trans; cl17247
1407053000073	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1407053000074	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1407053000075	substrate binding site [chemical binding]; other site
1407053000076	oxyanion hole (OAH) forming residues; other site
1407053000077	trimer interface [polypeptide binding]; other site
1407053000078	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1407053000079	Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118
1407053000080	NAD(P) binding site [chemical binding]; other site
1407053000081	catalytic residues [active]
1407053000082	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
1407053000083	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1407053000084	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745
1407053000085	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1407053000086	NAD(P) binding site [chemical binding]; other site
1407053000087	active site
1407053000088	Domain of unknown function (DUF4354); Region: DUF4354; pfam14263
1407053000089	Uncharacterized conserved protein [Function unknown]; Region: COG3791
1407053000090	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1407053000091	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1407053000092	NAD(P) binding site [chemical binding]; other site
1407053000093	active site
1407053000094	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1407053000095	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
1407053000096	metal binding site [ion binding]; metal-binding site
1407053000097	putative dimer interface [polypeptide binding]; other site
1407053000098	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1407053000099	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1407053000100	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1407053000101	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
1407053000102	CPxP  motif; other site
1407053000103	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
1407053000104	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
1407053000105	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1407053000106	ADP binding site [chemical binding]; other site
1407053000107	magnesium binding site [ion binding]; other site
1407053000108	putative shikimate binding site; other site
1407053000109	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
1407053000110	active site
1407053000111	dimer interface [polypeptide binding]; other site
1407053000112	metal binding site [ion binding]; metal-binding site
1407053000113	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
1407053000114	Domain of unknown function DUF21; Region: DUF21; pfam01595
1407053000115	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1407053000116	Transporter associated domain; Region: CorC_HlyC; smart01091
1407053000117	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
1407053000118	DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214
1407053000119	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1407053000120	HSP70 interaction site [polypeptide binding]; other site
1407053000121	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
1407053000122	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1407053000123	Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase) [Coenzyme metabolism]; Region: CobT; COG4547
1407053000124	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
1407053000125	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
1407053000126	metal ion-dependent adhesion site (MIDAS); other site
1407053000127	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1407053000128	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1407053000129	metal-binding site [ion binding]
1407053000130	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1407053000131	metal-binding site [ion binding]
1407053000132	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1407053000133	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1407053000134	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
1407053000135	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1407053000136	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
1407053000137	DNA binding residues [nucleotide binding]
1407053000138	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
1407053000139	dimer interface [polypeptide binding]; other site
1407053000140	putative metal binding site [ion binding]; other site
1407053000141	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1407053000142	Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738
1407053000143	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
1407053000144	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1407053000145	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1407053000146	active site
1407053000147	phosphorylation site [posttranslational modification]
1407053000148	intermolecular recognition site; other site
1407053000149	dimerization interface [polypeptide binding]; other site
1407053000150	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1407053000151	DNA binding site [nucleotide binding]
1407053000152	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1407053000153	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1407053000154	ligand binding site [chemical binding]; other site
1407053000155	flexible hinge region; other site
1407053000156	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1407053000157	putative catalytic site [active]
1407053000158	putative metal binding site [ion binding]; other site
1407053000159	putative phosphate binding site [ion binding]; other site
1407053000160	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
1407053000161	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
1407053000162	aquaporin Z; Provisional; Region: PRK05420
1407053000163	amphipathic channel; other site
1407053000164	Asn-Pro-Ala signature motifs; other site
1407053000165	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
1407053000166	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1407053000167	Walker A/P-loop; other site
1407053000168	ATP binding site [chemical binding]; other site
1407053000169	Q-loop/lid; other site
1407053000170	ABC transporter signature motif; other site
1407053000171	Walker B; other site
1407053000172	D-loop; other site
1407053000173	H-loop/switch region; other site
1407053000174	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
1407053000175	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1407053000176	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1407053000177	putative acyl-acceptor binding pocket; other site
1407053000178	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
1407053000179	dimer interface [polypeptide binding]; other site
1407053000180	substrate binding site [chemical binding]; other site
1407053000181	metal binding sites [ion binding]; metal-binding site
1407053000182	YGGT family; Region: YGGT; pfam02325
1407053000183	Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703
1407053000184	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
1407053000185	putative active site pocket [active]
1407053000186	dimerization interface [polypeptide binding]; other site
1407053000187	putative catalytic residue [active]
1407053000188	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
1407053000189	prephenate dehydrogenase; Validated; Region: PRK08507
1407053000190	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1407053000191	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1407053000192	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1407053000193	active site
1407053000194	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
1407053000195	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1407053000196	active site
1407053000197	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1407053000198	substrate binding site [chemical binding]; other site
1407053000199	catalytic residues [active]
1407053000200	dimer interface [polypeptide binding]; other site
1407053000201	Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567
1407053000202	argininosuccinate lyase; Provisional; Region: PRK00855
1407053000203	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1407053000204	active sites [active]
1407053000205	tetramer interface [polypeptide binding]; other site
1407053000206	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1407053000207	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1407053000208	catalytic residues [active]
1407053000209	hypothetical protein; Validated; Region: PRK00124
1407053000210	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
1407053000211	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
1407053000212	7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365
1407053000213	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
1407053000214	6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720
1407053000215	active site
1407053000216	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
1407053000217	Ligand Binding Site [chemical binding]; other site
1407053000218	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1407053000219	Ligand binding site [chemical binding]; other site
1407053000220	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1407053000221	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
1407053000222	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
1407053000223	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1407053000224	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530
1407053000225	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1407053000226	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1407053000227	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1407053000228	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1407053000229	dimer interface [polypeptide binding]; other site
1407053000230	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1407053000231	catalytic residue [active]
1407053000232	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1407053000233	Ligand Binding Site [chemical binding]; other site
1407053000234	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1407053000235	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1407053000236	catalytic residue [active]
1407053000237	phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881
1407053000238	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1407053000239	putative substrate translocation pore; other site
1407053000240	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1407053000241	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1407053000242	DNA-binding site [nucleotide binding]; DNA binding site
1407053000243	FCD domain; Region: FCD; pfam07729
1407053000244	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
1407053000245	active site
1407053000246	homotetramer interface [polypeptide binding]; other site
1407053000247	homodimer interface [polypeptide binding]; other site
1407053000248	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1407053000249	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1407053000250	Walker A/P-loop; other site
1407053000251	ATP binding site [chemical binding]; other site
1407053000252	Q-loop/lid; other site
1407053000253	ABC transporter signature motif; other site
1407053000254	Walker B; other site
1407053000255	D-loop; other site
1407053000256	H-loop/switch region; other site
1407053000257	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
1407053000258	Aspartase; Region: Aspartase; cd01357
1407053000259	active sites [active]
1407053000260	tetramer interface [polypeptide binding]; other site
1407053000261	agmatinase; Region: agmatinase; TIGR01230
1407053000262	Agmatinase and related proteins; Region: Agmatinase_like_1; cd11589
1407053000263	oligomer interface [polypeptide binding]; other site
1407053000264	active site
1407053000265	Mn binding site [ion binding]; other site
1407053000266	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1407053000267	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1407053000268	Walker A/P-loop; other site
1407053000269	ATP binding site [chemical binding]; other site
1407053000270	Q-loop/lid; other site
1407053000271	ABC transporter signature motif; other site
1407053000272	Walker B; other site
1407053000273	D-loop; other site
1407053000274	H-loop/switch region; other site
1407053000275	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1407053000276	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053000277	dimer interface [polypeptide binding]; other site
1407053000278	conserved gate region; other site
1407053000279	putative PBP binding loops; other site
1407053000280	ABC-ATPase subunit interface; other site
1407053000281	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1407053000282	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053000283	dimer interface [polypeptide binding]; other site
1407053000284	conserved gate region; other site
1407053000285	putative PBP binding loops; other site
1407053000286	ABC-ATPase subunit interface; other site
1407053000287	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1407053000288	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1407053000289	substrate binding pocket [chemical binding]; other site
1407053000290	membrane-bound complex binding site; other site
1407053000291	hinge residues; other site
1407053000292	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1407053000293	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1407053000294	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1407053000295	dimerization interface [polypeptide binding]; other site
1407053000296	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
1407053000297	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
1407053000298	Sulfatase; Region: Sulfatase; pfam00884
1407053000299	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
1407053000300	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
1407053000301	Preprotein translocase subunit SecA (ATPase, RNA helicase) [Intracellular trafficking and secretion]; Region: SecA; COG0653
1407053000302	DEAD/DEAH box helicase; Region: DEAD; pfam00270
1407053000303	ATP binding site [chemical binding]; other site
1407053000304	putative Mg++ binding site [ion binding]; other site
1407053000305	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1407053000306	SEC-C motif; Region: SEC-C; pfam02810
1407053000307	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1407053000308	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
1407053000309	heterotetramer interface [polypeptide binding]; other site
1407053000310	active site pocket [active]
1407053000311	cleavage site
1407053000312	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1407053000313	Coenzyme A binding pocket [chemical binding]; other site
1407053000314	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
1407053000315	active site
1407053000316	8-oxo-dGMP binding site [chemical binding]; other site
1407053000317	nudix motif; other site
1407053000318	metal binding site [ion binding]; metal-binding site
1407053000319	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
1407053000320	intracellular septation protein A; Reviewed; Region: PRK00259
1407053000321	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1407053000322	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1407053000323	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1407053000324	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1407053000325	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
1407053000326	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1407053000327	FeS/SAM binding site; other site
1407053000328	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
1407053000329	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1407053000330	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1407053000331	Protease inhibitor Inh; Region: Inh; pfam02974
1407053000332	Predicted ATPase [General function prediction only]; Region: COG1485
1407053000333	malate dehydrogenase; Reviewed; Region: PRK06223
1407053000334	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
1407053000335	NAD(P) binding site [chemical binding]; other site
1407053000336	dimer interface [polypeptide binding]; other site
1407053000337	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1407053000338	substrate binding site [chemical binding]; other site
1407053000339	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
1407053000340	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
1407053000341	CoA-ligase; Region: Ligase_CoA; pfam00549
1407053000342	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
1407053000343	CoA binding domain; Region: CoA_binding; smart00881
1407053000344	CoA-ligase; Region: Ligase_CoA; pfam00549
1407053000345	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
1407053000346	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
1407053000347	TPP-binding site [chemical binding]; other site
1407053000348	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
1407053000349	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
1407053000350	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1407053000351	E3 interaction surface; other site
1407053000352	lipoyl attachment site [posttranslational modification]; other site
1407053000353	e3 binding domain; Region: E3_binding; pfam02817
1407053000354	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1407053000355	Predicted membrane protein [Function unknown]; Region: COG3686
1407053000356	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1407053000357	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
1407053000358	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1407053000359	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1407053000360	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1407053000361	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735
1407053000362	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
1407053000363	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1407053000364	active site
1407053000365	DNA binding site [nucleotide binding]
1407053000366	Int/Topo IB signature motif; other site
1407053000367	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1407053000368	RimM N-terminal domain; Region: RimM; pfam01782
1407053000369	PRC-barrel domain; Region: PRC; pfam05239
1407053000370	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1407053000371	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1407053000372	dimerization interface [polypeptide binding]; other site
1407053000373	putative DNA binding site [nucleotide binding]; other site
1407053000374	putative Zn2+ binding site [ion binding]; other site
1407053000375	NIPSNAP; Region: NIPSNAP; pfam07978
1407053000376	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1407053000377	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1407053000378	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1407053000379	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1407053000380	substrate binding site [chemical binding]; other site
1407053000381	ligand binding site [chemical binding]; other site
1407053000382	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1407053000383	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1407053000384	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1407053000385	Coenzyme A binding pocket [chemical binding]; other site
1407053000386	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
1407053000387	Iron-sulfur protein interface; other site
1407053000388	proximal quinone binding site [chemical binding]; other site
1407053000389	SdhD (CybS) interface [polypeptide binding]; other site
1407053000390	proximal heme binding site [chemical binding]; other site
1407053000391	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495
1407053000392	putative SdhC subunit interface [polypeptide binding]; other site
1407053000393	putative proximal heme binding site [chemical binding]; other site
1407053000394	putative Iron-sulfur protein interface [polypeptide binding]; other site
1407053000395	putative proximal quinone binding site; other site
1407053000396	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
1407053000397	L-aspartate oxidase; Provisional; Region: PRK06175
1407053000398	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1407053000399	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
1407053000400	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1407053000401	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333
1407053000402	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1407053000403	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
1407053000404	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
1407053000405	active site
1407053000406	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
1407053000407	catalytic triad [active]
1407053000408	dimer interface [polypeptide binding]; other site
1407053000409	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1407053000410	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1407053000411	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1407053000412	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1407053000413	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1407053000414	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1407053000415	DNA-binding site [nucleotide binding]; DNA binding site
1407053000416	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1407053000417	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1407053000418	homodimer interface [polypeptide binding]; other site
1407053000419	catalytic residue [active]
1407053000420	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1407053000421	EamA-like transporter family; Region: EamA; pfam00892
1407053000422	Predicted methyltransferase [General function prediction only]; Region: COG3897
1407053000423	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1407053000424	S-adenosylmethionine binding site [chemical binding]; other site
1407053000425	Uncharacterized conserved protein [Function unknown]; Region: COG2947
1407053000426	YciI-like protein; Reviewed; Region: PRK12863
1407053000427	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1407053000428	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1407053000429	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1407053000430	UGMP family protein; Validated; Region: PRK09604
1407053000431	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
1407053000432	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
1407053000433	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
1407053000434	domain interfaces; other site
1407053000435	active site
1407053000436	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
1407053000437	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1407053000438	active site
1407053000439	Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898
1407053000440	HemY protein N-terminus; Region: HemY_N; pfam07219
1407053000441	tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313
1407053000442	putative metal binding site [ion binding]; other site
1407053000443	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
1407053000444	Methyltransferase domain; Region: Methyltransf_11; pfam08241
1407053000445	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
1407053000446	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1407053000447	active site
1407053000448	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
1407053000449	GSH binding site [chemical binding]; other site
1407053000450	catalytic residues [active]
1407053000451	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1407053000452	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
1407053000453	putative active site [active]
1407053000454	catalytic triad [active]
1407053000455	dimer interface [polypeptide binding]; other site
1407053000456	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5319
1407053000457	EamA-like transporter family; Region: EamA; pfam00892
1407053000458	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1407053000459	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
1407053000460	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1407053000461	S-adenosylmethionine binding site [chemical binding]; other site
1407053000462	aspartate kinase; Reviewed; Region: PRK06635
1407053000463	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
1407053000464	putative nucleotide binding site [chemical binding]; other site
1407053000465	putative catalytic residues [active]
1407053000466	putative Mg ion binding site [ion binding]; other site
1407053000467	putative aspartate binding site [chemical binding]; other site
1407053000468	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
1407053000469	putative allosteric regulatory site; other site
1407053000470	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
1407053000471	putative allosteric regulatory residue; other site
1407053000472	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
1407053000473	GAF domain; Region: GAF; pfam01590
1407053000474	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1407053000475	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1407053000476	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1407053000477	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1407053000478	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1407053000479	RF-1 domain; Region: RF-1; pfam00472
1407053000480	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
1407053000481	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1407053000482	S-adenosylmethionine binding site [chemical binding]; other site
1407053000483	Domain of unknown function (DUF4167); Region: DUF4167; pfam13763
1407053000484	Clp amino terminal domain; Region: Clp_N; pfam02861
1407053000485	Clp amino terminal domain; Region: Clp_N; pfam02861
1407053000486	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1407053000487	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1407053000488	Walker A motif; other site
1407053000489	ATP binding site [chemical binding]; other site
1407053000490	Walker B motif; other site
1407053000491	arginine finger; other site
1407053000492	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1407053000493	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1407053000494	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1407053000495	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1407053000496	Peptidase family M23; Region: Peptidase_M23; pfam01551
1407053000497	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1407053000498	Integrase core domain; Region: rve; pfam00665
1407053000499	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
1407053000500	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
1407053000501	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1407053000502	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1407053000503	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1407053000504	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1407053000505	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1407053000506	GTPase CgtA; Reviewed; Region: obgE; PRK12299
1407053000507	GTP1/OBG; Region: GTP1_OBG; pfam01018
1407053000508	Obg GTPase; Region: Obg; cd01898
1407053000509	G1 box; other site
1407053000510	GTP/Mg2+ binding site [chemical binding]; other site
1407053000511	Switch I region; other site
1407053000512	G2 box; other site
1407053000513	G3 box; other site
1407053000514	Switch II region; other site
1407053000515	G4 box; other site
1407053000516	G5 box; other site
1407053000517	gamma-glutamyl kinase; Provisional; Region: PRK05429
1407053000518	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
1407053000519	nucleotide binding site [chemical binding]; other site
1407053000520	homotetrameric interface [polypeptide binding]; other site
1407053000521	putative phosphate binding site [ion binding]; other site
1407053000522	putative allosteric binding site; other site
1407053000523	PUA domain; Region: PUA; pfam01472
1407053000524	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
1407053000525	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
1407053000526	putative catalytic cysteine [active]
1407053000527	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1407053000528	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
1407053000529	active site
1407053000530	(T/H)XGH motif; other site
1407053000531	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
1407053000532	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
1407053000533	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
1407053000534	Peptidase family M23; Region: Peptidase_M23; pfam01551
1407053000535	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
1407053000536	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1407053000537	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1407053000538	protein binding site [polypeptide binding]; other site
1407053000539	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1407053000540	Catalytic dyad [active]
1407053000541	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
1407053000542	putative active site [active]
1407053000543	Ap4A binding site [chemical binding]; other site
1407053000544	nudix motif; other site
1407053000545	putative metal binding site [ion binding]; other site
1407053000546	Predicted membrane protein [Function unknown]; Region: COG3619
1407053000547	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1407053000548	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1407053000549	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1407053000550	putative effector binding pocket; other site
1407053000551	dimerization interface [polypeptide binding]; other site
1407053000552	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
1407053000553	active site clefts [active]
1407053000554	zinc binding site [ion binding]; other site
1407053000555	dimer interface [polypeptide binding]; other site
1407053000556	chorismate mutase; Provisional; Region: PRK09239
1407053000557	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
1407053000558	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
1407053000559	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
1407053000560	Repair protein; Region: Repair_PSII; pfam04536
1407053000561	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
1407053000562	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1407053000563	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1407053000564	purine monophosphate binding site [chemical binding]; other site
1407053000565	dimer interface [polypeptide binding]; other site
1407053000566	putative catalytic residues [active]
1407053000567	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1407053000568	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
1407053000569	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5360
1407053000570	NusB family; Region: NusB; pfam01029
1407053000571	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
1407053000572	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1407053000573	S-adenosylmethionine binding site [chemical binding]; other site
1407053000574	heat shock protein HtpX; Provisional; Region: PRK01345
1407053000575	Usg protein, probable subunit of phosphoribosylanthranilate isomerase [Amino acid transport and metabolism]; Region: COG5425
1407053000576	Predicted membrane protein [Function unknown]; Region: COG1289
1407053000577	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1407053000578	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
1407053000579	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1407053000580	catalytic residue [active]
1407053000581	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1407053000582	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1407053000583	HIGH motif; other site
1407053000584	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1407053000585	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1407053000586	active site
1407053000587	KMSKS motif; other site
1407053000588	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1407053000589	tRNA binding surface [nucleotide binding]; other site
1407053000590	Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5468
1407053000591	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
1407053000592	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
1407053000593	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1407053000594	core domain interface [polypeptide binding]; other site
1407053000595	delta subunit interface [polypeptide binding]; other site
1407053000596	epsilon subunit interface [polypeptide binding]; other site
1407053000597	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1407053000598	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1407053000599	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1407053000600	alpha subunit interaction interface [polypeptide binding]; other site
1407053000601	Walker A motif; other site
1407053000602	ATP binding site [chemical binding]; other site
1407053000603	Walker B motif; other site
1407053000604	inhibitor binding site; inhibition site
1407053000605	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1407053000606	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
1407053000607	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1407053000608	gamma subunit interface [polypeptide binding]; other site
1407053000609	LBP interface [polypeptide binding]; other site
1407053000610	MarR family; Region: MarR; pfam01047
1407053000611	transcriptional regulator SlyA; Provisional; Region: PRK03573
1407053000612	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1407053000613	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1407053000614	DNA-binding site [nucleotide binding]; DNA binding site
1407053000615	FCD domain; Region: FCD; pfam07729
1407053000616	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1407053000617	Proline racemase [Amino acid transport and metabolism]; Region: COG3938
1407053000618	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
1407053000619	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1407053000620	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1407053000621	TM-ABC transporter signature motif; other site
1407053000622	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1407053000623	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1407053000624	Walker A/P-loop; other site
1407053000625	ATP binding site [chemical binding]; other site
1407053000626	Q-loop/lid; other site
1407053000627	ABC transporter signature motif; other site
1407053000628	Walker B; other site
1407053000629	D-loop; other site
1407053000630	H-loop/switch region; other site
1407053000631	Uncharacterized conserved protein [Function unknown]; Region: COG3743
1407053000632	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1407053000633	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1407053000634	Walker A/P-loop; other site
1407053000635	ATP binding site [chemical binding]; other site
1407053000636	Q-loop/lid; other site
1407053000637	ABC transporter signature motif; other site
1407053000638	Walker B; other site
1407053000639	D-loop; other site
1407053000640	H-loop/switch region; other site
1407053000641	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1407053000642	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1407053000643	dimerization interface [polypeptide binding]; other site
1407053000644	ligand binding site [chemical binding]; other site
1407053000645	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1407053000646	pyruvate carboxylase subunit B; Validated; Region: PRK09282
1407053000647	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
1407053000648	active site
1407053000649	catalytic residues [active]
1407053000650	metal binding site [ion binding]; metal-binding site
1407053000651	homodimer binding site [polypeptide binding]; other site
1407053000652	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1407053000653	carboxyltransferase (CT) interaction site; other site
1407053000654	biotinylation site [posttranslational modification]; other site
1407053000655	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1407053000656	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1407053000657	putative substrate translocation pore; other site
1407053000658	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1407053000659	active site
1407053000660	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
1407053000661	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1407053000662	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1407053000663	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1407053000664	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1407053000665	substrate binding pocket [chemical binding]; other site
1407053000666	chain length determination region; other site
1407053000667	substrate-Mg2+ binding site; other site
1407053000668	catalytic residues [active]
1407053000669	aspartate-rich region 1; other site
1407053000670	active site lid residues [active]
1407053000671	aspartate-rich region 2; other site
1407053000672	Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333
1407053000673	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1407053000674	dimer interface [polypeptide binding]; other site
1407053000675	putative acyltransferase; Provisional; Region: PRK05790
1407053000676	active site
1407053000677	DEAD/DEAH box helicase; Region: DEAD; pfam00270
1407053000678	ATP binding site [chemical binding]; other site
1407053000679	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1407053000680	putative Mg++ binding site [ion binding]; other site
1407053000681	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1407053000682	nucleotide binding region [chemical binding]; other site
1407053000683	ATP-binding site [chemical binding]; other site
1407053000684	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1407053000685	RNA binding surface [nucleotide binding]; other site
1407053000686	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
1407053000687	4Fe-4S binding domain; Region: Fer4; pfam00037
1407053000688	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
1407053000689	RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500
1407053000690	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1407053000691	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1407053000692	DNA binding residues [nucleotide binding]
1407053000693	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
1407053000694	MOSC domain; Region: MOSC; pfam03473
1407053000695	3-alpha domain; Region: 3-alpha; pfam03475
1407053000696	Peptidase family M48; Region: Peptidase_M48; pfam01435
1407053000697	ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840
1407053000698	ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298
1407053000699	Walker A/P-loop; other site
1407053000700	ATP binding site [chemical binding]; other site
1407053000701	Q-loop/lid; other site
1407053000702	ABC transporter signature motif; other site
1407053000703	Walker B; other site
1407053000704	D-loop; other site
1407053000705	H-loop/switch region; other site
1407053000706	thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433
1407053000707	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053000708	dimer interface [polypeptide binding]; other site
1407053000709	conserved gate region; other site
1407053000710	putative PBP binding loops; other site
1407053000711	ABC-ATPase subunit interface; other site
1407053000712	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053000713	dimer interface [polypeptide binding]; other site
1407053000714	conserved gate region; other site
1407053000715	putative PBP binding loops; other site
1407053000716	ABC-ATPase subunit interface; other site
1407053000717	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
1407053000718	thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205
1407053000719	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
1407053000720	Thiamine pyrophosphokinase; Region: TPK; cd07995
1407053000721	active site
1407053000722	dimerization interface [polypeptide binding]; other site
1407053000723	thiamine binding site [chemical binding]; other site
1407053000724	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1407053000725	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1407053000726	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1407053000727	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3750
1407053000728	Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931
1407053000729	Predicted integral membrane protein [Function unknown]; Region: COG5480
1407053000730	Pyruvate kinase, alpha/beta domain; Region: PK_C; pfam02887
1407053000731	TPR repeat; Region: TPR_11; pfam13414
1407053000732	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1407053000733	TPR motif; other site
1407053000734	binding surface
1407053000735	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
1407053000736	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1407053000737	NAD binding site [chemical binding]; other site
1407053000738	ATP-grasp domain; Region: ATP-grasp; pfam02222
1407053000739	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
1407053000740	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1407053000741	putative substrate translocation pore; other site
1407053000742	Uncharacterized small protein containing a coiled-coil domain [Function unknown]; Region: COG5509
1407053000743	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
1407053000744	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
1407053000745	NAD(P) binding site [chemical binding]; other site
1407053000746	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1407053000747	CoenzymeA binding site [chemical binding]; other site
1407053000748	subunit interaction site [polypeptide binding]; other site
1407053000749	PHB binding site; other site
1407053000750	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
1407053000751	Predicted transcriptional regulator [Transcription]; Region: COG2378
1407053000752	HTH domain; Region: HTH_11; pfam08279
1407053000753	WYL domain; Region: WYL; pfam13280
1407053000754	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
1407053000755	Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967
1407053000756	acyl-activating enzyme (AAE) consensus motif; other site
1407053000757	putative AMP binding site [chemical binding]; other site
1407053000758	putative active site [active]
1407053000759	putative CoA binding site [chemical binding]; other site
1407053000760	Phosphoglycerate kinase; Region: PGK; pfam00162
1407053000761	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
1407053000762	substrate binding site [chemical binding]; other site
1407053000763	hinge regions; other site
1407053000764	ADP binding site [chemical binding]; other site
1407053000765	catalytic site [active]
1407053000766	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
1407053000767	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1407053000768	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1407053000769	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1407053000770	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1407053000771	TPP-binding site [chemical binding]; other site
1407053000772	dimer interface [polypeptide binding]; other site
1407053000773	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1407053000774	PYR/PP interface [polypeptide binding]; other site
1407053000775	dimer interface [polypeptide binding]; other site
1407053000776	TPP binding site [chemical binding]; other site
1407053000777	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1407053000778	Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division,    chromosome partitioning]; Region: zapA; COG3027
1407053000779	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
1407053000780	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
1407053000781	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1407053000782	putative active site [active]
1407053000783	metal binding site [ion binding]; metal-binding site
1407053000784	homodimer binding site [polypeptide binding]; other site
1407053000785	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
1407053000786	Uncharacterized conserved protein [Function unknown]; Region: COG3543
1407053000787	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
1407053000788	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1407053000789	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1407053000790	DNA-binding site [nucleotide binding]; DNA binding site
1407053000791	FCD domain; Region: FCD; pfam07729
1407053000792	hypothetical protein; Validated; Region: PRK00110
1407053000793	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528
1407053000794	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
1407053000795	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1407053000796	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1407053000797	Walker A/P-loop; other site
1407053000798	ATP binding site [chemical binding]; other site
1407053000799	Q-loop/lid; other site
1407053000800	ABC transporter signature motif; other site
1407053000801	Walker B; other site
1407053000802	D-loop; other site
1407053000803	H-loop/switch region; other site
1407053000804	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1407053000805	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
1407053000806	active site
1407053000807	dimerization interface [polypeptide binding]; other site
1407053000808	elongation factor P; Validated; Region: PRK00529
1407053000809	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1407053000810	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1407053000811	RNA binding site [nucleotide binding]; other site
1407053000812	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1407053000813	RNA binding site [nucleotide binding]; other site
1407053000814	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1407053000815	Sel1-like repeats; Region: SEL1; smart00671
1407053000816	Sel1-like repeats; Region: SEL1; smart00671
1407053000817	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1407053000818	active site
1407053000819	thiamine phosphate binding site [chemical binding]; other site
1407053000820	pyrophosphate binding site [ion binding]; other site
1407053000821	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4645
1407053000822	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1407053000823	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1407053000824	RuvA N terminal domain; Region: RuvA_N; pfam01330
1407053000825	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
1407053000826	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1407053000827	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1407053000828	Walker A motif; other site
1407053000829	ATP binding site [chemical binding]; other site
1407053000830	Walker B motif; other site
1407053000831	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1407053000832	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1407053000833	active site
1407053000834	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1407053000835	TolR protein; Region: tolR; TIGR02801
1407053000836	putative outer membrane lipoprotein; Provisional; Region: PRK09967
1407053000837	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1407053000838	ligand binding site [chemical binding]; other site
1407053000839	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
1407053000840	Tetratricopeptide repeat; Region: TPR_6; pfam13174
1407053000841	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1407053000842	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1407053000843	FtsH Extracellular; Region: FtsH_ext; pfam06480
1407053000844	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1407053000845	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1407053000846	Walker A motif; other site
1407053000847	ATP binding site [chemical binding]; other site
1407053000848	Walker B motif; other site
1407053000849	arginine finger; other site
1407053000850	Peptidase family M41; Region: Peptidase_M41; pfam01434
1407053000851	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315
1407053000852	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1407053000853	active site
1407053000854	substrate binding site [chemical binding]; other site
1407053000855	metal binding site [ion binding]; metal-binding site
1407053000856	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
1407053000857	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
1407053000858	Sodium Bile acid symporter family; Region: SBF; pfam01758
1407053000859	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
1407053000860	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1407053000861	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1407053000862	catalytic residue [active]
1407053000863	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
1407053000864	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
1407053000865	ligand binding site [chemical binding]; other site
1407053000866	NAD binding site [chemical binding]; other site
1407053000867	dimerization interface [polypeptide binding]; other site
1407053000868	catalytic site [active]
1407053000869	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
1407053000870	putative L-serine binding site [chemical binding]; other site
1407053000871	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1407053000872	Cytochrome P450; Region: p450; cl12078
1407053000873	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1407053000874	Coenzyme A binding pocket [chemical binding]; other site
1407053000875	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1407053000876	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1407053000877	GDP-binding site [chemical binding]; other site
1407053000878	ACT binding site; other site
1407053000879	IMP binding site; other site
1407053000880	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1407053000881	metabolite-proton symporter; Region: 2A0106; TIGR00883
1407053000882	putative substrate translocation pore; other site
1407053000883	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
1407053000884	diiron binding motif [ion binding]; other site
1407053000885	Uncharacterized conserved protein [Function unknown]; Region: COG1633
1407053000886	CCC1-related protein family; Region: CCC1_like_1; cd02437
1407053000887	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
1407053000888	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
1407053000889	putative active site [active]
1407053000890	putative dimer interface [polypeptide binding]; other site
1407053000891	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1407053000892	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1407053000893	dimerization interface [polypeptide binding]; other site
1407053000894	putative DNA binding site [nucleotide binding]; other site
1407053000895	putative Zn2+ binding site [ion binding]; other site
1407053000896	AsnC family; Region: AsnC_trans_reg; pfam01037
1407053000897	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1407053000898	trimer interface [polypeptide binding]; other site
1407053000899	active site
1407053000900	macrolide transporter subunit MacA; Provisional; Region: PRK11578
1407053000901	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1407053000902	HlyD family secretion protein; Region: HlyD_3; pfam13437
1407053000903	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
1407053000904	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1407053000905	Walker A/P-loop; other site
1407053000906	ATP binding site [chemical binding]; other site
1407053000907	Q-loop/lid; other site
1407053000908	ABC transporter signature motif; other site
1407053000909	Walker B; other site
1407053000910	D-loop; other site
1407053000911	H-loop/switch region; other site
1407053000912	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1407053000913	FtsX-like permease family; Region: FtsX; pfam02687
1407053000914	Predicted periplasmic protein [Function unknown]; Region: COG3698
1407053000915	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
1407053000916	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
1407053000917	TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352
1407053000918	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1407053000919	TonB system transport protein ExbD, group 1; Region: ExbD_1; TIGR02803
1407053000920	tonB-system energizer ExbB; Region: exbB; TIGR02797
1407053000921	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
1407053000922	CHASE3 domain; Region: CHASE3; pfam05227
1407053000923	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1407053000924	Histidine kinase; Region: HisKA_2; pfam07568
1407053000925	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1407053000926	ATP binding site [chemical binding]; other site
1407053000927	Mg2+ binding site [ion binding]; other site
1407053000928	G-X-G motif; other site
1407053000929	RNA polymerase sigma factor; Provisional; Region: PRK12516
1407053000930	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1407053000931	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1407053000932	DNA binding residues [nucleotide binding]
1407053000933	two-component response regulator; Provisional; Region: PRK09191
1407053000934	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1407053000935	active site
1407053000936	phosphorylation site [posttranslational modification]
1407053000937	intermolecular recognition site; other site
1407053000938	dimerization interface [polypeptide binding]; other site
1407053000939	PAS fold; Region: PAS_4; pfam08448
1407053000940	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1407053000941	HWE histidine kinase; Region: HWE_HK; pfam07536
1407053000942	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1407053000943	metal binding site 2 [ion binding]; metal-binding site
1407053000944	putative DNA binding helix; other site
1407053000945	metal binding site 1 [ion binding]; metal-binding site
1407053000946	dimer interface [polypeptide binding]; other site
1407053000947	structural Zn2+ binding site [ion binding]; other site
1407053000948	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1407053000949	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1407053000950	RNA binding surface [nucleotide binding]; other site
1407053000951	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1407053000952	active site
1407053000953	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
1407053000954	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1407053000955	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1407053000956	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1407053000957	DNA binding residues [nucleotide binding]
1407053000958	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1407053000959	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1407053000960	Coenzyme A binding pocket [chemical binding]; other site
1407053000961	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
1407053000962	Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008
1407053000963	active site
1407053000964	HIGH motif; other site
1407053000965	nucleotide binding site [chemical binding]; other site
1407053000966	active site
1407053000967	KMSKS motif; other site
1407053000968	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
1407053000969	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1407053000970	helix-hairpin-helix signature motif; other site
1407053000971	substrate binding pocket [chemical binding]; other site
1407053000972	active site
1407053000973	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
1407053000974	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1407053000975	active site
1407053000976	Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495
1407053000977	Predicted membrane protein [Function unknown]; Region: COG1238
1407053000978	succinic semialdehyde dehydrogenase; Region: PLN02278
1407053000979	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1407053000980	tetramerization interface [polypeptide binding]; other site
1407053000981	NAD(P) binding site [chemical binding]; other site
1407053000982	catalytic residues [active]
1407053000983	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
1407053000984	Uncharacterized conserved protein [Function unknown]; Region: COG5591
1407053000985	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
1407053000986	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1407053000987	putative ligand binding site [chemical binding]; other site
1407053000988	short chain dehydrogenase; Provisional; Region: PRK06841
1407053000989	classical (c) SDRs; Region: SDR_c; cd05233
1407053000990	NAD(P) binding site [chemical binding]; other site
1407053000991	active site
1407053000992	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
1407053000993	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
1407053000994	DAK2 domain; Region: Dak2; pfam02734
1407053000995	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1407053000996	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1407053000997	DNA binding residues [nucleotide binding]
1407053000998	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1407053000999	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
1407053001000	DAK2 domain; Region: Dak2; cl03685
1407053001001	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
1407053001002	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
1407053001003	7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113
1407053001004	7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365
1407053001005	NAD binding site [chemical binding]; other site
1407053001006	substrate binding site [chemical binding]; other site
1407053001007	homotetramer interface [polypeptide binding]; other site
1407053001008	homodimer interface [polypeptide binding]; other site
1407053001009	active site
1407053001010	7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113
1407053001011	7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365
1407053001012	NAD binding site [chemical binding]; other site
1407053001013	substrate binding site [chemical binding]; other site
1407053001014	homotetramer interface [polypeptide binding]; other site
1407053001015	homodimer interface [polypeptide binding]; other site
1407053001016	active site
1407053001017	isocitrate lyase; Provisional; Region: PRK15063
1407053001018	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1407053001019	tetramer interface [polypeptide binding]; other site
1407053001020	active site
1407053001021	Mg2+/Mn2+ binding site [ion binding]; other site
1407053001022	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
1407053001023	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1407053001024	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1407053001025	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
1407053001026	Walker A/P-loop; other site
1407053001027	ATP binding site [chemical binding]; other site
1407053001028	Q-loop/lid; other site
1407053001029	ABC transporter signature motif; other site
1407053001030	Walker B; other site
1407053001031	D-loop; other site
1407053001032	H-loop/switch region; other site
1407053001033	TOBE domain; Region: TOBE_2; pfam08402
1407053001034	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1407053001035	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
1407053001036	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1407053001037	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
1407053001038	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1407053001039	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1407053001040	inhibitor-cofactor binding pocket; inhibition site
1407053001041	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1407053001042	catalytic residue [active]
1407053001043	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1407053001044	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1407053001045	active site
1407053001046	phosphorylation site [posttranslational modification]
1407053001047	intermolecular recognition site; other site
1407053001048	dimerization interface [polypeptide binding]; other site
1407053001049	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1407053001050	DNA binding site [nucleotide binding]
1407053001051	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1407053001052	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
1407053001053	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1407053001054	Ligand Binding Site [chemical binding]; other site
1407053001055	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1407053001056	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
1407053001057	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1407053001058	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1407053001059	putative Zn2+ binding site [ion binding]; other site
1407053001060	putative DNA binding site [nucleotide binding]; other site
1407053001061	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1407053001062	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1407053001063	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1407053001064	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053001065	dimer interface [polypeptide binding]; other site
1407053001066	conserved gate region; other site
1407053001067	putative PBP binding loops; other site
1407053001068	ABC-ATPase subunit interface; other site
1407053001069	dipeptide transporter; Provisional; Region: PRK10913
1407053001070	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1407053001071	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053001072	dimer interface [polypeptide binding]; other site
1407053001073	conserved gate region; other site
1407053001074	putative PBP binding loops; other site
1407053001075	ABC-ATPase subunit interface; other site
1407053001076	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1407053001077	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1407053001078	Walker A/P-loop; other site
1407053001079	ATP binding site [chemical binding]; other site
1407053001080	Q-loop/lid; other site
1407053001081	ABC transporter signature motif; other site
1407053001082	Walker B; other site
1407053001083	D-loop; other site
1407053001084	H-loop/switch region; other site
1407053001085	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1407053001086	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053001087	dimer interface [polypeptide binding]; other site
1407053001088	conserved gate region; other site
1407053001089	putative PBP binding loops; other site
1407053001090	ABC-ATPase subunit interface; other site
1407053001091	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
1407053001092	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
1407053001093	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1407053001094	putative substrate translocation pore; other site
1407053001095	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1407053001096	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1407053001097	MarR family; Region: MarR_2; pfam12802
1407053001098	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
1407053001099	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1407053001100	putative DNA binding site [nucleotide binding]; other site
1407053001101	putative Zn2+ binding site [ion binding]; other site
1407053001102	AsnC family; Region: AsnC_trans_reg; pfam01037
1407053001103	anthranilate synthase; Provisional; Region: PRK13566
1407053001104	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1407053001105	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1407053001106	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1407053001107	glutamine binding [chemical binding]; other site
1407053001108	catalytic triad [active]
1407053001109	2-isopropylmalate synthase; Validated; Region: PRK03739
1407053001110	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
1407053001111	active site
1407053001112	catalytic residues [active]
1407053001113	metal binding site [ion binding]; metal-binding site
1407053001114	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
1407053001115	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1407053001116	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1407053001117	active site
1407053001118	metal binding site [ion binding]; metal-binding site
1407053001119	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680
1407053001120	nudix motif; other site
1407053001121	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
1407053001122	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
1407053001123	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
1407053001124	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
1407053001125	putative dimer interface [polypeptide binding]; other site
1407053001126	N-terminal domain interface [polypeptide binding]; other site
1407053001127	putative substrate binding pocket (H-site) [chemical binding]; other site
1407053001128	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1407053001129	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1407053001130	Coenzyme A binding pocket [chemical binding]; other site
1407053001131	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
1407053001132	N-terminal double-transmembrane domain; Region: two_anch; TIGR02226
1407053001133	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
1407053001134	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
1407053001135	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
1407053001136	Protein of unknown function DUF58; Region: DUF58; pfam01882
1407053001137	MoxR-like ATPases [General function prediction only]; Region: COG0714
1407053001138	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1407053001139	ATP binding site [chemical binding]; other site
1407053001140	Walker B motif; other site
1407053001141	arginine finger; other site
1407053001142	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
1407053001143	putative active site [active]
1407053001144	putative CoA binding site [chemical binding]; other site
1407053001145	nudix motif; other site
1407053001146	metal binding site [ion binding]; metal-binding site
1407053001147	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
1407053001148	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1407053001149	active site
1407053001150	NTP binding site [chemical binding]; other site
1407053001151	metal binding triad [ion binding]; metal-binding site
1407053001152	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1407053001153	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
1407053001154	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
1407053001155	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752
1407053001156	Purine nucleoside permease [Nucleotide transport and metabolism]; Region: NUP; COG5042
1407053001157	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
1407053001158	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1407053001159	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1407053001160	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1407053001161	Walker A/P-loop; other site
1407053001162	ATP binding site [chemical binding]; other site
1407053001163	Q-loop/lid; other site
1407053001164	ABC transporter signature motif; other site
1407053001165	Walker B; other site
1407053001166	D-loop; other site
1407053001167	H-loop/switch region; other site
1407053001168	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
1407053001169	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
1407053001170	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
1407053001171	[2Fe-2S] cluster binding site [ion binding]; other site
1407053001172	cytochrome b; Provisional; Region: CYTB; MTH00191
1407053001173	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
1407053001174	Qi binding site; other site
1407053001175	intrachain domain interface; other site
1407053001176	interchain domain interface [polypeptide binding]; other site
1407053001177	heme bH binding site [chemical binding]; other site
1407053001178	heme bL binding site [chemical binding]; other site
1407053001179	Qo binding site; other site
1407053001180	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
1407053001181	interchain domain interface [polypeptide binding]; other site
1407053001182	intrachain domain interface; other site
1407053001183	Qi binding site; other site
1407053001184	Qo binding site; other site
1407053001185	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
1407053001186	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1407053001187	active site
1407053001188	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
1407053001189	putative active site [active]
1407053001190	putative catalytic site [active]
1407053001191	GTP-binding protein YchF; Reviewed; Region: PRK09601
1407053001192	YchF GTPase; Region: YchF; cd01900
1407053001193	G1 box; other site
1407053001194	GTP/Mg2+ binding site [chemical binding]; other site
1407053001195	Switch I region; other site
1407053001196	G2 box; other site
1407053001197	Switch II region; other site
1407053001198	G3 box; other site
1407053001199	G4 box; other site
1407053001200	G5 box; other site
1407053001201	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1407053001202	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1407053001203	putative active site [active]
1407053001204	catalytic residue [active]
1407053001205	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
1407053001206	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
1407053001207	CTC domain interface [polypeptide binding]; other site
1407053001208	L16 interface [polypeptide binding]; other site
1407053001209	HerA helicase [Replication, recombination, and repair]; Region: COG0433
1407053001210	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
1407053001211	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1407053001212	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1407053001213	active site
1407053001214	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1407053001215	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1407053001216	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
1407053001217	active site
1407053001218	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
1407053001219	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
1407053001220	Uncharacterized conserved protein [Function unknown]; Region: COG1565
1407053001221	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
1407053001222	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960
1407053001223	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
1407053001224	dimer interface [polypeptide binding]; other site
1407053001225	putative tRNA-binding site [nucleotide binding]; other site
1407053001226	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
1407053001227	dimer interface [polypeptide binding]; other site
1407053001228	phosphorylation site [posttranslational modification]
1407053001229	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1407053001230	ATP binding site [chemical binding]; other site
1407053001231	Mg2+ binding site [ion binding]; other site
1407053001232	G-X-G motif; other site
1407053001233	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1407053001234	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1407053001235	active site
1407053001236	phosphorylation site [posttranslational modification]
1407053001237	intermolecular recognition site; other site
1407053001238	dimerization interface [polypeptide binding]; other site
1407053001239	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1407053001240	DNA binding site [nucleotide binding]
1407053001241	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1407053001242	MarR family; Region: MarR_2; pfam12802
1407053001243	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1407053001244	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1407053001245	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1407053001246	catalytic residue [active]
1407053001247	excinuclease ABC subunit B; Provisional; Region: PRK05298
1407053001248	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1407053001249	ATP binding site [chemical binding]; other site
1407053001250	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1407053001251	nucleotide binding region [chemical binding]; other site
1407053001252	ATP-binding site [chemical binding]; other site
1407053001253	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1407053001254	UvrB/uvrC motif; Region: UVR; pfam02151
1407053001255	Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991
1407053001256	Bacterial SH3 domain; Region: SH3_3; pfam08239
1407053001257	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1407053001258	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921
1407053001259	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
1407053001260	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1407053001261	EamA-like transporter family; Region: EamA; pfam00892
1407053001262	EamA-like transporter family; Region: EamA; pfam00892
1407053001263	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1407053001264	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1407053001265	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1407053001266	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1407053001267	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1407053001268	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1407053001269	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1407053001270	putative DNA binding site [nucleotide binding]; other site
1407053001271	putative Zn2+ binding site [ion binding]; other site
1407053001272	AsnC family; Region: AsnC_trans_reg; pfam01037
1407053001273	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1407053001274	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1407053001275	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1407053001276	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1407053001277	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1407053001278	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1407053001279	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1407053001280	putative effector binding pocket; other site
1407053001281	dimerization interface [polypeptide binding]; other site
1407053001282	aspartate aminotransferase; Provisional; Region: PRK05764
1407053001283	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1407053001284	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1407053001285	homodimer interface [polypeptide binding]; other site
1407053001286	catalytic residue [active]
1407053001287	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1407053001288	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
1407053001289	putative C-terminal domain interface [polypeptide binding]; other site
1407053001290	putative GSH binding site (G-site) [chemical binding]; other site
1407053001291	putative dimer interface [polypeptide binding]; other site
1407053001292	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1407053001293	N-terminal domain interface [polypeptide binding]; other site
1407053001294	dimer interface [polypeptide binding]; other site
1407053001295	substrate binding pocket (H-site) [chemical binding]; other site
1407053001296	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1407053001297	DNA-binding site [nucleotide binding]; DNA binding site
1407053001298	RNA-binding motif; other site
1407053001299	NUDIX domain; Region: NUDIX; pfam00293
1407053001300	nudix motif; other site
1407053001301	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
1407053001302	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
1407053001303	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
1407053001304	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
1407053001305	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1407053001306	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1407053001307	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1407053001308	IMP binding site; other site
1407053001309	dimer interface [polypeptide binding]; other site
1407053001310	partial ornithine binding site; other site
1407053001311	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1407053001312	Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458
1407053001313	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1407053001314	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1407053001315	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096
1407053001316	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1407053001317	LytTr DNA-binding domain; Region: LytTR; pfam04397
1407053001318	Predicted membrane protein [Function unknown]; Region: COG5395
1407053001319	Predicted metalloprotease [General function prediction only]; Region: COG2321
1407053001320	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
1407053001321	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1407053001322	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
1407053001323	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1407053001324	catalytic site [active]
1407053001325	subunit interface [polypeptide binding]; other site
1407053001326	DNA primase; Validated; Region: dnaG; PRK05667
1407053001327	CHC2 zinc finger; Region: zf-CHC2; pfam01807
1407053001328	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1407053001329	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1407053001330	active site
1407053001331	metal binding site [ion binding]; metal-binding site
1407053001332	interdomain interaction site; other site
1407053001333	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1407053001334	active site
1407053001335	metal binding site [ion binding]; metal-binding site
1407053001336	interdomain interaction site; other site
1407053001337	hypothetical protein; Provisional; Region: PRK05170
1407053001338	Uncharacterized conserved protein [Function unknown]; Region: COG2968
1407053001339	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
1407053001340	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1407053001341	active site
1407053001342	catalytic residues [active]
1407053001343	DNA binding site [nucleotide binding]
1407053001344	Int/Topo IB signature motif; other site
1407053001345	Invasion associated locus B (IalB) protein; Region: IalB; cl02207
1407053001346	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899
1407053001347	Isochorismatase family; Region: Isochorismatase; pfam00857
1407053001348	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
1407053001349	catalytic triad [active]
1407053001350	metal binding site [ion binding]; metal-binding site
1407053001351	conserved cis-peptide bond; other site
1407053001352	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
1407053001353	PhnA protein; Region: PhnA; pfam03831
1407053001354	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1407053001355	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
1407053001356	FAD binding pocket [chemical binding]; other site
1407053001357	FAD binding motif [chemical binding]; other site
1407053001358	phosphate binding motif [ion binding]; other site
1407053001359	beta-alpha-beta structure motif; other site
1407053001360	NAD binding pocket [chemical binding]; other site
1407053001361	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1407053001362	catalytic loop [active]
1407053001363	iron binding site [ion binding]; other site
1407053001364	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1407053001365	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1407053001366	[2Fe-2S] cluster binding site [ion binding]; other site
1407053001367	C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884
1407053001368	putative alpha subunit interface [polypeptide binding]; other site
1407053001369	putative active site [active]
1407053001370	putative substrate binding site [chemical binding]; other site
1407053001371	Fe binding site [ion binding]; other site
1407053001372	Protein of unknown function (DUF1498); Region: DUF1498; pfam07385
1407053001373	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1407053001374	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1407053001375	PGAP1-like protein; Region: PGAP1; pfam07819
1407053001376	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
1407053001377	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1407053001378	Walker A/P-loop; other site
1407053001379	ATP binding site [chemical binding]; other site
1407053001380	Q-loop/lid; other site
1407053001381	ABC transporter signature motif; other site
1407053001382	Walker B; other site
1407053001383	D-loop; other site
1407053001384	H-loop/switch region; other site
1407053001385	ABC transporter; Region: ABC_tran_2; pfam12848
1407053001386	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1407053001387	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
1407053001388	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1407053001389	S-adenosylmethionine binding site [chemical binding]; other site
1407053001390	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
1407053001391	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1407053001392	putative substrate translocation pore; other site
1407053001393	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1407053001394	dimerization interface [polypeptide binding]; other site
1407053001395	putative DNA binding site [nucleotide binding]; other site
1407053001396	putative Zn2+ binding site [ion binding]; other site
1407053001397	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1407053001398	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1407053001399	S-adenosylmethionine binding site [chemical binding]; other site
1407053001400	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
1407053001401	FAD binding site [chemical binding]; other site
1407053001402	Predicted permeases [General function prediction only]; Region: COG0679
1407053001403	Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757
1407053001404	Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413
1407053001405	active site
1407053001406	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
1407053001407	DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076
1407053001408	putative metal binding site [ion binding]; other site
1407053001409	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1407053001410	HSP70 interaction site [polypeptide binding]; other site
1407053001411	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1407053001412	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1407053001413	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1407053001414	catalytic residue [active]
1407053001415	manganese transport protein MntH; Reviewed; Region: PRK00701
1407053001416	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1407053001417	Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462
1407053001418	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1407053001419	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1407053001420	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1407053001421	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1407053001422	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1407053001423	Mg++ binding site [ion binding]; other site
1407053001424	putative catalytic motif [active]
1407053001425	putative substrate binding site [chemical binding]; other site
1407053001426	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390
1407053001427	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1407053001428	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1407053001429	cell division protein FtsW; Region: ftsW; TIGR02614
1407053001430	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1407053001431	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
1407053001432	active site
1407053001433	homodimer interface [polypeptide binding]; other site
1407053001434	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
1407053001435	FAD binding domain; Region: FAD_binding_4; pfam01565
1407053001436	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1407053001437	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
1407053001438	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1407053001439	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1407053001440	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
1407053001441	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1407053001442	Cell division protein FtsQ; Region: FtsQ; pfam03799
1407053001443	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
1407053001444	Cell division protein FtsA; Region: FtsA; smart00842
1407053001445	Cell division protein FtsA; Region: FtsA; pfam14450
1407053001446	cell division protein FtsZ; Validated; Region: PRK09330
1407053001447	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1407053001448	nucleotide binding site [chemical binding]; other site
1407053001449	SulA interaction site; other site
1407053001450	cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483
1407053001451	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
1407053001452	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
1407053001453	DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105
1407053001454	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1407053001455	binding surface
1407053001456	TPR motif; other site
1407053001457	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
1407053001458	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1407053001459	Walker A/P-loop; other site
1407053001460	ATP binding site [chemical binding]; other site
1407053001461	Q-loop/lid; other site
1407053001462	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1407053001463	ABC transporter signature motif; other site
1407053001464	Walker B; other site
1407053001465	D-loop; other site
1407053001466	H-loop/switch region; other site
1407053001467	Ligase N family; Region: LIGANc; smart00532
1407053001468	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1407053001469	nucleotide binding pocket [chemical binding]; other site
1407053001470	K-X-D-G motif; other site
1407053001471	catalytic site [active]
1407053001472	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1407053001473	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1407053001474	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
1407053001475	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
1407053001476	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1407053001477	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
1407053001478	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
1407053001479	Cu(I) binding site [ion binding]; other site
1407053001480	phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308
1407053001481	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
1407053001482	trimer interface [polypeptide binding]; other site
1407053001483	active site
1407053001484	substrate binding site [chemical binding]; other site
1407053001485	CoA binding site [chemical binding]; other site
1407053001486	Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045
1407053001487	CreA protein; Region: CreA; pfam05981
1407053001488	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
1407053001489	Part of AAA domain; Region: AAA_19; pfam13245
1407053001490	Family description; Region: UvrD_C_2; pfam13538
1407053001491	serine/threonine protein kinase; Provisional; Region: PRK09188
1407053001492	serine/threonine protein kinase; Provisional; Region: PRK12274
1407053001493	Uncharacterized conserved protein [Function unknown]; Region: COG4702
1407053001494	FAD binding domain; Region: FAD_binding_4; pfam01565
1407053001495	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1407053001496	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814
1407053001497	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
1407053001498	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1407053001499	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
1407053001500	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1407053001501	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
1407053001502	thymidylate synthase; Reviewed; Region: thyA; PRK01827
1407053001503	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1407053001504	dimerization interface [polypeptide binding]; other site
1407053001505	active site
1407053001506	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1407053001507	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1407053001508	folate binding site [chemical binding]; other site
1407053001509	NADP+ binding site [chemical binding]; other site
1407053001510	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
1407053001511	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
1407053001512	HflK protein; Region: hflK; TIGR01933
1407053001513	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1407053001514	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
1407053001515	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242
1407053001516	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
1407053001517	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1407053001518	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1407053001519	protein binding site [polypeptide binding]; other site
1407053001520	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1407053001521	protein binding site [polypeptide binding]; other site
1407053001522	Predicted flavoproteins [General function prediction only]; Region: COG2081
1407053001523	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1407053001524	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1407053001525	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1407053001526	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1407053001527	motif II; other site
1407053001528	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1407053001529	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1407053001530	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1407053001531	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
1407053001532	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1407053001533	putative valine binding site [chemical binding]; other site
1407053001534	dimer interface [polypeptide binding]; other site
1407053001535	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
1407053001536	ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507
1407053001537	AAA domain; Region: AAA_30; pfam13604
1407053001538	Family description; Region: UvrD_C_2; pfam13538
1407053001539	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cl00541
1407053001540	active site
1407053001541	hydrophilic channel; other site
1407053001542	catalytic residues [active]
1407053001543	active site lid [active]
1407053001544	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
1407053001545	potassium uptake protein; Region: kup; TIGR00794
1407053001546	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1407053001547	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1407053001548	ketol-acid reductoisomerase; Provisional; Region: PRK05479
1407053001549	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1407053001550	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1407053001551	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
1407053001552	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1407053001553	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1407053001554	homodimer interface [polypeptide binding]; other site
1407053001555	catalytic residue [active]
1407053001556	BA14K-like protein; Region: BA14K; pfam07886
1407053001557	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
1407053001558	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
1407053001559	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
1407053001560	camphor resistance protein CrcB; Provisional; Region: ccrB; PRK01636
1407053001561	Uncharacterized conserved protein [Function unknown]; Region: COG3439
1407053001562	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1407053001563	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1407053001564	Walker A/P-loop; other site
1407053001565	ATP binding site [chemical binding]; other site
1407053001566	Q-loop/lid; other site
1407053001567	ABC transporter signature motif; other site
1407053001568	Walker B; other site
1407053001569	D-loop; other site
1407053001570	H-loop/switch region; other site
1407053001571	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
1407053001572	cobalt transport protein CbiM; Validated; Region: PRK06265
1407053001573	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
1407053001574	ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266
1407053001575	Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413
1407053001576	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
1407053001577	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1407053001578	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
1407053001579	UreF; Region: UreF; pfam01730
1407053001580	urease accessory protein UreE; Provisional; Region: ureE; PRK14711
1407053001581	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
1407053001582	dimer interface [polypeptide binding]; other site
1407053001583	catalytic residues [active]
1407053001584	urease subunit alpha; Reviewed; Region: ureC; PRK13309
1407053001585	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
1407053001586	subunit interactions [polypeptide binding]; other site
1407053001587	active site
1407053001588	flap region; other site
1407053001589	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
1407053001590	alpha-beta subunit interface [polypeptide binding]; other site
1407053001591	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
1407053001592	alpha-gamma subunit interface [polypeptide binding]; other site
1407053001593	beta-gamma subunit interface [polypeptide binding]; other site
1407053001594	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1407053001595	HlyD family secretion protein; Region: HlyD_3; pfam13437
1407053001596	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1407053001597	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1407053001598	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
1407053001599	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1407053001600	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1407053001601	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
1407053001602	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1407053001603	N-terminal plug; other site
1407053001604	ligand-binding site [chemical binding]; other site
1407053001605	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1407053001606	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1407053001607	intersubunit interface [polypeptide binding]; other site
1407053001608	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1407053001609	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1407053001610	ABC-ATPase subunit  interface; other site
1407053001611	dimer interface [polypeptide binding]; other site
1407053001612	putative PBP binding regions; other site
1407053001613	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1407053001614	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1407053001615	Walker A/P-loop; other site
1407053001616	ATP binding site [chemical binding]; other site
1407053001617	Q-loop/lid; other site
1407053001618	ABC transporter signature motif; other site
1407053001619	Walker B; other site
1407053001620	D-loop; other site
1407053001621	H-loop/switch region; other site
1407053001622	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1407053001623	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1407053001624	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1407053001625	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312
1407053001626	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1407053001627	putative ligand binding site [chemical binding]; other site
1407053001628	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1407053001629	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1407053001630	ABC transporter signature motif; other site
1407053001631	Walker B; other site
1407053001632	D-loop; other site
1407053001633	H-loop/switch region; other site
1407053001634	short chain dehydrogenase; Provisional; Region: PRK06198
1407053001635	classical (c) SDRs; Region: SDR_c; cd05233
1407053001636	NAD(P) binding site [chemical binding]; other site
1407053001637	active site
1407053001638	Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154
1407053001639	EF-hand domain pair; Region: EF_hand_5; pfam13499
1407053001640	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
1407053001641	Ca2+ binding site [ion binding]; other site
1407053001642	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
1407053001643	Ca2+ binding site [ion binding]; other site
1407053001644	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1407053001645	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1407053001646	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
1407053001647	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1407053001648	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1407053001649	Transporter associated domain; Region: CorC_HlyC; smart01091
1407053001650	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1407053001651	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1407053001652	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1407053001653	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053001654	dimer interface [polypeptide binding]; other site
1407053001655	conserved gate region; other site
1407053001656	putative PBP binding loops; other site
1407053001657	ABC-ATPase subunit interface; other site
1407053001658	sulfate transport protein; Provisional; Region: cysT; CHL00187
1407053001659	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053001660	dimer interface [polypeptide binding]; other site
1407053001661	conserved gate region; other site
1407053001662	putative PBP binding loops; other site
1407053001663	ABC-ATPase subunit interface; other site
1407053001664	Serine hydrolase; Region: Ser_hydrolase; pfam06821
1407053001665	Predicted integral membrane protein [Function unknown]; Region: COG0392
1407053001666	putative cation:proton antiport protein; Provisional; Region: PRK10669
1407053001667	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
1407053001668	TrkA-N domain; Region: TrkA_N; pfam02254
1407053001669	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
1407053001670	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1407053001671	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1407053001672	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
1407053001673	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1407053001674	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
1407053001675	conserved cys residue [active]
1407053001676	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1407053001677	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1407053001678	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1407053001679	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1407053001680	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1407053001681	dimerization interface [polypeptide binding]; other site
1407053001682	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1407053001683	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
1407053001684	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1407053001685	Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162
1407053001686	substrate binding pocket [chemical binding]; other site
1407053001687	FAD binding site [chemical binding]; other site
1407053001688	catalytic base [active]
1407053001689	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
1407053001690	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1407053001691	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1407053001692	cobalt transporter subunit CbtB (proposed); Region: CbtB; TIGR02459
1407053001693	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
1407053001694	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
1407053001695	homotrimer interface [polypeptide binding]; other site
1407053001696	Walker A motif; other site
1407053001697	GTP binding site [chemical binding]; other site
1407053001698	Walker B motif; other site
1407053001699	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
1407053001700	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1407053001701	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1407053001702	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
1407053001703	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
1407053001704	homodimer interface [polypeptide binding]; other site
1407053001705	Walker A motif; other site
1407053001706	ATP binding site [chemical binding]; other site
1407053001707	hydroxycobalamin binding site [chemical binding]; other site
1407053001708	Walker B motif; other site
1407053001709	Predicted membrane protein [Function unknown]; Region: COG2510
1407053001710	hypothetical protein; Provisional; Region: PRK10621
1407053001711	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1407053001712	tellurium resistance terB-like protein; Region: terB_like; cd07177
1407053001713	metal binding site [ion binding]; metal-binding site
1407053001714	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
1407053001715	active site
1407053001716	SAM binding site [chemical binding]; other site
1407053001717	homodimer interface [polypeptide binding]; other site
1407053001718	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
1407053001719	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
1407053001720	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1407053001721	active site
1407053001722	SAM binding site [chemical binding]; other site
1407053001723	homodimer interface [polypeptide binding]; other site
1407053001724	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
1407053001725	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1407053001726	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
1407053001727	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
1407053001728	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1407053001729	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1407053001730	homodimer interface [polypeptide binding]; other site
1407053001731	catalytic residue [active]
1407053001732	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
1407053001733	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1407053001734	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
1407053001735	ligand binding site [chemical binding]; other site
1407053001736	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1407053001737	Flavin Reductases; Region: FlaRed; cl00801
1407053001738	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1407053001739	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
1407053001740	active site
1407053001741	SAM binding site [chemical binding]; other site
1407053001742	homodimer interface [polypeptide binding]; other site
1407053001743	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
1407053001744	Precorrin-8X methylmutase; Region: CbiC; pfam02570
1407053001745	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1407053001746	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
1407053001747	active site
1407053001748	SAM binding site [chemical binding]; other site
1407053001749	putative homodimer interface [polypeptide binding]; other site
1407053001750	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
1407053001751	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1407053001752	S-adenosylmethionine binding site [chemical binding]; other site
1407053001753	DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003
1407053001754	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1407053001755	MPN+ (JAMM) motif; other site
1407053001756	Zinc-binding site [ion binding]; other site
1407053001757	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1407053001758	active site
1407053001759	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
1407053001760	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
1407053001761	Peptidase M15; Region: Peptidase_M15_3; cl01194
1407053001762	homoserine dehydrogenase; Provisional; Region: PRK06349
1407053001763	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1407053001764	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1407053001765	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
1407053001766	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
1407053001767	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
1407053001768	putative active site [active]
1407053001769	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1407053001770	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
1407053001771	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1407053001772	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
1407053001773	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1407053001774	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1407053001775	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395
1407053001776	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1407053001777	DNA-binding site [nucleotide binding]; DNA binding site
1407053001778	RNA-binding motif; other site
1407053001779	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1407053001780	DNA-binding site [nucleotide binding]; DNA binding site
1407053001781	RNA-binding motif; other site
1407053001782	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1407053001783	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1407053001784	serine acetyltransferase; Provisional; Region: cysE; PRK11132
1407053001785	Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971
1407053001786	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1407053001787	trimer interface [polypeptide binding]; other site
1407053001788	active site
1407053001789	substrate binding site [chemical binding]; other site
1407053001790	CoA binding site [chemical binding]; other site
1407053001791	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
1407053001792	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
1407053001793	trimer interface [polypeptide binding]; other site
1407053001794	putative metal binding site [ion binding]; other site
1407053001795	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035
1407053001796	PAS domain; Region: PAS_5; pfam07310
1407053001797	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388
1407053001798	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
1407053001799	FOG: CBS domain [General function prediction only]; Region: COG0517
1407053001800	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
1407053001801	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1407053001802	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
1407053001803	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1407053001804	elongation factor Tu; Reviewed; Region: PRK00049
1407053001805	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1407053001806	G1 box; other site
1407053001807	GEF interaction site [polypeptide binding]; other site
1407053001808	GTP/Mg2+ binding site [chemical binding]; other site
1407053001809	Switch I region; other site
1407053001810	G2 box; other site
1407053001811	G3 box; other site
1407053001812	Switch II region; other site
1407053001813	G4 box; other site
1407053001814	G5 box; other site
1407053001815	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1407053001816	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1407053001817	Antibiotic Binding Site [chemical binding]; other site
1407053001818	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
1407053001819	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1407053001820	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1407053001821	putative homodimer interface [polypeptide binding]; other site
1407053001822	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1407053001823	heterodimer interface [polypeptide binding]; other site
1407053001824	homodimer interface [polypeptide binding]; other site
1407053001825	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1407053001826	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1407053001827	23S rRNA interface [nucleotide binding]; other site
1407053001828	L7/L12 interface [polypeptide binding]; other site
1407053001829	putative thiostrepton binding site; other site
1407053001830	L25 interface [polypeptide binding]; other site
1407053001831	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1407053001832	mRNA/rRNA interface [nucleotide binding]; other site
1407053001833	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1407053001834	23S rRNA interface [nucleotide binding]; other site
1407053001835	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1407053001836	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1407053001837	L11 interface [polypeptide binding]; other site
1407053001838	putative EF-Tu interaction site [polypeptide binding]; other site
1407053001839	putative EF-G interaction site [polypeptide binding]; other site
1407053001840	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
1407053001841	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
1407053001842	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
1407053001843	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
1407053001844	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1407053001845	DNA binding site [nucleotide binding]
1407053001846	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1407053001847	Ribosomal protein S12-like family; composed of prokaryotic 30S ribosomal protein S12, eukaryotic 40S ribosomal protein S23 and similar proteins. S12 and S23 are located at the interface of the large and small ribosomal subunits, adjacent to the decoding...; Region: Ribosomal_S12_like; cl00312
1407053001848	30S ribosomal protein S7; Validated; Region: PRK05302
1407053001849	elongation factor G; Reviewed; Region: PRK00007
1407053001850	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1407053001851	G1 box; other site
1407053001852	putative GEF interaction site [polypeptide binding]; other site
1407053001853	GTP/Mg2+ binding site [chemical binding]; other site
1407053001854	Switch I region; other site
1407053001855	G2 box; other site
1407053001856	G3 box; other site
1407053001857	Switch II region; other site
1407053001858	G4 box; other site
1407053001859	G5 box; other site
1407053001860	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1407053001861	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1407053001862	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1407053001863	elongation factor Tu; Reviewed; Region: PRK00049
1407053001864	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1407053001865	G1 box; other site
1407053001866	GEF interaction site [polypeptide binding]; other site
1407053001867	GTP/Mg2+ binding site [chemical binding]; other site
1407053001868	Switch I region; other site
1407053001869	G2 box; other site
1407053001870	G3 box; other site
1407053001871	Switch II region; other site
1407053001872	G4 box; other site
1407053001873	G5 box; other site
1407053001874	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1407053001875	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1407053001876	Antibiotic Binding Site [chemical binding]; other site
1407053001877	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1407053001878	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1407053001879	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1407053001880	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1407053001881	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1407053001882	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1407053001883	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1407053001884	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1407053001885	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1407053001886	G-X-X-G motif; other site
1407053001887	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1407053001888	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1407053001889	23S rRNA interface [nucleotide binding]; other site
1407053001890	5S rRNA interface [nucleotide binding]; other site
1407053001891	putative antibiotic binding site [chemical binding]; other site
1407053001892	L25 interface [polypeptide binding]; other site
1407053001893	L27 interface [polypeptide binding]; other site
1407053001894	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1407053001895	23S rRNA interface [nucleotide binding]; other site
1407053001896	putative translocon interaction site; other site
1407053001897	signal recognition particle (SRP54) interaction site; other site
1407053001898	L23 interface [polypeptide binding]; other site
1407053001899	trigger factor interaction site; other site
1407053001900	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1407053001901	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1407053001902	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1407053001903	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1407053001904	RNA binding site [nucleotide binding]; other site
1407053001905	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
1407053001906	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1407053001907	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1407053001908	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1407053001909	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1407053001910	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1407053001911	5S rRNA interface [nucleotide binding]; other site
1407053001912	23S rRNA interface [nucleotide binding]; other site
1407053001913	L5 interface [polypeptide binding]; other site
1407053001914	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1407053001915	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1407053001916	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1407053001917	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
1407053001918	23S rRNA binding site [nucleotide binding]; other site
1407053001919	adenylate kinase; Reviewed; Region: adk; PRK00279
1407053001920	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1407053001921	AMP-binding site [chemical binding]; other site
1407053001922	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1407053001923	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
1407053001924	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1407053001925	30S ribosomal protein S11; Validated; Region: PRK05309
1407053001926	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1407053001927	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1407053001928	alphaNTD homodimer interface [polypeptide binding]; other site
1407053001929	alphaNTD - beta interaction site [polypeptide binding]; other site
1407053001930	alphaNTD - beta' interaction site [polypeptide binding]; other site
1407053001931	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1407053001932	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1407053001933	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
1407053001934	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1407053001935	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1407053001936	protein binding site [polypeptide binding]; other site
1407053001937	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1407053001938	protein binding site [polypeptide binding]; other site
1407053001939	recombination factor protein RarA; Reviewed; Region: PRK13342
1407053001940	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1407053001941	Walker A motif; other site
1407053001942	ATP binding site [chemical binding]; other site
1407053001943	Walker B motif; other site
1407053001944	arginine finger; other site
1407053001945	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1407053001946	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1407053001947	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1407053001948	catalytic residue [active]
1407053001949	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1407053001950	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1407053001951	ligand binding site [chemical binding]; other site
1407053001952	recombinase A; Provisional; Region: recA; PRK09354
1407053001953	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1407053001954	hexamer interface [polypeptide binding]; other site
1407053001955	Walker A motif; other site
1407053001956	ATP binding site [chemical binding]; other site
1407053001957	Walker B motif; other site
1407053001958	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1407053001959	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1407053001960	motif 1; other site
1407053001961	active site
1407053001962	motif 2; other site
1407053001963	motif 3; other site
1407053001964	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1407053001965	alkaline phosphatase; Provisional; Region: PRK10518
1407053001966	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
1407053001967	dimer interface [polypeptide binding]; other site
1407053001968	active site
1407053001969	isocitrate dehydrogenase; Validated; Region: PRK08299
1407053001970	Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321
1407053001971	intracellular protease, PfpI family; Region: PfpI; TIGR01382
1407053001972	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
1407053001973	conserved cys residue [active]
1407053001974	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
1407053001975	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
1407053001976	glutamate racemase; Provisional; Region: PRK00865
1407053001977	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
1407053001978	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1407053001979	TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123
1407053001980	DctM-like transporters; Region: DctM; pfam06808
1407053001981	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
1407053001982	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
1407053001983	active site
1407053001984	substrate binding site [chemical binding]; other site
1407053001985	coenzyme B12 binding site [chemical binding]; other site
1407053001986	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
1407053001987	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1407053001988	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1407053001989	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1407053001990	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1407053001991	carboxyltransferase (CT) interaction site; other site
1407053001992	biotinylation site [posttranslational modification]; other site
1407053001993	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1407053001994	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1407053001995	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1407053001996	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1407053001997	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1407053001998	non-specific DNA binding site [nucleotide binding]; other site
1407053001999	salt bridge; other site
1407053002000	sequence-specific DNA binding site [nucleotide binding]; other site
1407053002001	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
1407053002002	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1407053002003	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
1407053002004	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
1407053002005	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1407053002006	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
1407053002007	DNA binding residues [nucleotide binding]
1407053002008	putative dimer interface [polypeptide binding]; other site
1407053002009	Predicted membrane protein [Function unknown]; Region: COG3503
1407053002010	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
1407053002011	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1407053002012	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
1407053002013	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1407053002014	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1407053002015	Uncharacterized conserved protein [Function unknown]; Region: COG2127
1407053002016	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_3; cd08585
1407053002017	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1407053002018	putative active site [active]
1407053002019	catalytic site [active]
1407053002020	putative metal binding site [ion binding]; other site
1407053002021	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
1407053002022	homotrimer interaction site [polypeptide binding]; other site
1407053002023	putative active site [active]
1407053002024	Domain of unknown function (DUF1849); Region: DUF1849; pfam08904
1407053002025	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
1407053002026	SnoaL-like domain; Region: SnoaL_3; pfam13474
1407053002027	elongation factor Ts; Provisional; Region: tsf; PRK09377
1407053002028	UBA/TS-N domain; Region: UBA; pfam00627
1407053002029	Elongation factor TS; Region: EF_TS; pfam00889
1407053002030	Elongation factor TS; Region: EF_TS; pfam00889
1407053002031	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1407053002032	putative nucleotide binding site [chemical binding]; other site
1407053002033	uridine monophosphate binding site [chemical binding]; other site
1407053002034	homohexameric interface [polypeptide binding]; other site
1407053002035	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1407053002036	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1407053002037	hinge region; other site
1407053002038	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
1407053002039	catalytic residue [active]
1407053002040	putative FPP diphosphate  binding site; other site
1407053002041	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240
1407053002042	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
1407053002043	dimer interface [polypeptide binding]; other site
1407053002044	putative IPP diphosphate binding site; other site
1407053002045	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1407053002046	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
1407053002047	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
1407053002048	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1407053002049	active site
1407053002050	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1407053002051	protein binding site [polypeptide binding]; other site
1407053002052	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1407053002053	putative substrate binding region [chemical binding]; other site
1407053002054	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
1407053002055	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
1407053002056	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
1407053002057	trimer interface [polypeptide binding]; other site
1407053002058	active site
1407053002059	UDP-GlcNAc binding site [chemical binding]; other site
1407053002060	lipid binding site [chemical binding]; lipid-binding site
1407053002061	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1407053002062	Acyl-[acyl carrier protein]; Region: LpxA; COG1043
1407053002063	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
1407053002064	active site
1407053002065	Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763
1407053002066	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
1407053002067	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
1407053002068	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
1407053002069	dimer interface [polypeptide binding]; other site
1407053002070	active site
1407053002071	citrylCoA binding site [chemical binding]; other site
1407053002072	NADH binding [chemical binding]; other site
1407053002073	cationic pore residues; other site
1407053002074	oxalacetate/citrate binding site [chemical binding]; other site
1407053002075	coenzyme A binding site [chemical binding]; other site
1407053002076	catalytic triad [active]
1407053002077	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1407053002078	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1407053002079	active site
1407053002080	HIGH motif; other site
1407053002081	nucleotide binding site [chemical binding]; other site
1407053002082	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1407053002083	active site
1407053002084	KMSKS motif; other site
1407053002085	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
1407053002086	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
1407053002087	Competence protein; Region: Competence; pfam03772
1407053002088	LexA repressor; Validated; Region: PRK00215
1407053002089	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
1407053002090	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1407053002091	Catalytic site [active]
1407053002092	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1407053002093	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1407053002094	dimer interface [polypeptide binding]; other site
1407053002095	putative functional site; other site
1407053002096	putative MPT binding site; other site
1407053002097	MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242
1407053002098	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1407053002099	active site
1407053002100	ribulose/triose binding site [chemical binding]; other site
1407053002101	phosphate binding site [ion binding]; other site
1407053002102	substrate (anthranilate) binding pocket [chemical binding]; other site
1407053002103	product (indole) binding pocket [chemical binding]; other site
1407053002104	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1407053002105	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1407053002106	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1407053002107	SurA N-terminal domain; Region: SurA_N_3; cl07813
1407053002108	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
1407053002109	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
1407053002110	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
1407053002111	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1407053002112	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1407053002113	CTP synthetase; Validated; Region: pyrG; PRK05380
1407053002114	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1407053002115	Catalytic site [active]
1407053002116	active site
1407053002117	UTP binding site [chemical binding]; other site
1407053002118	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1407053002119	active site
1407053002120	putative oxyanion hole; other site
1407053002121	catalytic triad [active]
1407053002122	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1407053002123	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
1407053002124	enolase; Provisional; Region: eno; PRK00077
1407053002125	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1407053002126	dimer interface [polypeptide binding]; other site
1407053002127	metal binding site [ion binding]; metal-binding site
1407053002128	substrate binding pocket [chemical binding]; other site
1407053002129	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1407053002130	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1407053002131	S-adenosylmethionine binding site [chemical binding]; other site
1407053002132	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
1407053002133	Septum formation initiator; Region: DivIC; pfam04977
1407053002134	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
1407053002135	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1407053002136	tetramer interface [polypeptide binding]; other site
1407053002137	TPP-binding site [chemical binding]; other site
1407053002138	heterodimer interface [polypeptide binding]; other site
1407053002139	phosphorylation loop region [posttranslational modification]
1407053002140	pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892
1407053002141	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1407053002142	E3 interaction surface; other site
1407053002143	lipoyl attachment site [posttranslational modification]; other site
1407053002144	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1407053002145	alpha subunit interface [polypeptide binding]; other site
1407053002146	TPP binding site [chemical binding]; other site
1407053002147	heterodimer interface [polypeptide binding]; other site
1407053002148	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1407053002149	lipoyl synthase; Provisional; Region: PRK05481
1407053002150	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1407053002151	FeS/SAM binding site; other site
1407053002152	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
1407053002153	putative coenzyme Q binding site [chemical binding]; other site
1407053002154	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
1407053002155	classical (c) SDRs; Region: SDR_c; cd05233
1407053002156	NAD(P) binding site [chemical binding]; other site
1407053002157	active site
1407053002158	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
1407053002159	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
1407053002160	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1407053002161	substrate binding site; other site
1407053002162	dimer interface; other site
1407053002163	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
1407053002164	homotrimer interaction site [polypeptide binding]; other site
1407053002165	zinc binding site [ion binding]; other site
1407053002166	CDP-binding sites; other site
1407053002167	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1407053002168	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1407053002169	dimer interface [polypeptide binding]; other site
1407053002170	phosphorylation site [posttranslational modification]
1407053002171	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1407053002172	ATP binding site [chemical binding]; other site
1407053002173	Mg2+ binding site [ion binding]; other site
1407053002174	G-X-G motif; other site
1407053002175	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1407053002176	dimerization interface [polypeptide binding]; other site
1407053002177	PAS domain; Region: PAS_9; pfam13426
1407053002178	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1407053002179	dimer interface [polypeptide binding]; other site
1407053002180	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1407053002181	phosphorylation site [posttranslational modification]
1407053002182	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1407053002183	Mg2+ binding site [ion binding]; other site
1407053002184	G-X-G motif; other site
1407053002185	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1407053002186	TrkA-N domain; Region: TrkA_N; pfam02254
1407053002187	TrkA-C domain; Region: TrkA_C; pfam02080
1407053002188	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1407053002189	TrkA-N domain; Region: TrkA_N; pfam02254
1407053002190	bacterial Hfq-like; Region: Hfq; cd01716
1407053002191	hexamer interface [polypeptide binding]; other site
1407053002192	Sm1 motif; other site
1407053002193	RNA binding site [nucleotide binding]; other site
1407053002194	Sm2 motif; other site
1407053002195	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
1407053002196	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1407053002197	HflX GTPase family; Region: HflX; cd01878
1407053002198	G1 box; other site
1407053002199	GTP/Mg2+ binding site [chemical binding]; other site
1407053002200	Switch I region; other site
1407053002201	G2 box; other site
1407053002202	G3 box; other site
1407053002203	Switch II region; other site
1407053002204	G4 box; other site
1407053002205	G5 box; other site
1407053002206	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
1407053002207	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1407053002208	oligomer interface [polypeptide binding]; other site
1407053002209	active site residues [active]
1407053002210	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1407053002211	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
1407053002212	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1407053002213	Walker A motif; other site
1407053002214	ATP binding site [chemical binding]; other site
1407053002215	Walker B motif; other site
1407053002216	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1407053002217	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
1407053002218	Found in ATP-dependent protease La (LON); Region: LON; smart00464
1407053002219	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1407053002220	Walker A motif; other site
1407053002221	ATP binding site [chemical binding]; other site
1407053002222	Walker B motif; other site
1407053002223	arginine finger; other site
1407053002224	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1407053002225	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1407053002226	IHF dimer interface [polypeptide binding]; other site
1407053002227	IHF - DNA interface [nucleotide binding]; other site
1407053002228	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1407053002229	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1407053002230	AAA domain; Region: AAA_21; pfam13304
1407053002231	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1407053002232	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1407053002233	dimer interface [polypeptide binding]; other site
1407053002234	ssDNA binding site [nucleotide binding]; other site
1407053002235	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1407053002236	phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325
1407053002237	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1407053002238	DNA-binding site [nucleotide binding]; DNA binding site
1407053002239	UTRA domain; Region: UTRA; pfam07702
1407053002240	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1407053002241	DNA gyrase subunit A; Validated; Region: PRK05560
1407053002242	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1407053002243	active site
1407053002244	primary dimer interface [polypeptide binding]; other site
1407053002245	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1407053002246	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1407053002247	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1407053002248	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1407053002249	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1407053002250	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1407053002251	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1407053002252	active site
1407053002253	(T/H)XGH motif; other site
1407053002254	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
1407053002255	active site
1407053002256	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
1407053002257	active site
1407053002258	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
1407053002259	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
1407053002260	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
1407053002261	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
1407053002262	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1407053002263	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1407053002264	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1407053002265	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1407053002266	HlyD family secretion protein; Region: HlyD_3; pfam13437
1407053002267	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1407053002268	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
1407053002269	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1407053002270	FAD binding site [chemical binding]; other site
1407053002271	substrate binding pocket [chemical binding]; other site
1407053002272	catalytic base [active]
1407053002273	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1407053002274	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1407053002275	Prophage antirepressor [Transcription]; Region: COG3617
1407053002276	BRO family, N-terminal domain; Region: Bro-N; smart01040
1407053002277	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1407053002278	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1407053002279	active site
1407053002280	DNA binding site [nucleotide binding]
1407053002281	Int/Topo IB signature motif; other site
1407053002282	hypothetical protein; Provisional; Region: PRK10279
1407053002283	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
1407053002284	nucleophile elbow; other site
1407053002285	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
1407053002286	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
1407053002287	homodecamer interface [polypeptide binding]; other site
1407053002288	GTP cyclohydrolase I; Provisional; Region: PLN03044
1407053002289	active site
1407053002290	putative catalytic site residues [active]
1407053002291	zinc binding site [ion binding]; other site
1407053002292	GTP-CH-I/GFRP interaction surface; other site
1407053002293	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
1407053002294	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1407053002295	trimerization site [polypeptide binding]; other site
1407053002296	active site
1407053002297	hypothetical protein; Validated; Region: PRK00041
1407053002298	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1407053002299	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1407053002300	Sporulation related domain; Region: SPOR; pfam05036
1407053002301	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
1407053002302	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
1407053002303	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1407053002304	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1407053002305	active site
1407053002306	dimer interface [polypeptide binding]; other site
1407053002307	motif 1; other site
1407053002308	motif 2; other site
1407053002309	motif 3; other site
1407053002310	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1407053002311	anticodon binding site; other site
1407053002312	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
1407053002313	putative FMN binding site [chemical binding]; other site
1407053002314	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1407053002315	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1407053002316	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
1407053002317	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
1407053002318	Tetratricopeptide repeat; Region: TPR_1; pfam00515
1407053002319	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1407053002320	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1407053002321	S-adenosylmethionine binding site [chemical binding]; other site
1407053002322	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1407053002323	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1407053002324	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
1407053002325	active site
1407053002326	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1407053002327	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
1407053002328	putative NAD(P) binding site [chemical binding]; other site
1407053002329	putative substrate binding site [chemical binding]; other site
1407053002330	catalytic Zn binding site [ion binding]; other site
1407053002331	structural Zn binding site [ion binding]; other site
1407053002332	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1407053002333	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1407053002334	HlyD family secretion protein; Region: HlyD_3; pfam13437
1407053002335	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1407053002336	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1407053002337	putative substrate translocation pore; other site
1407053002338	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
1407053002339	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
1407053002340	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
1407053002341	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1407053002342	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1407053002343	metal binding site [ion binding]; metal-binding site
1407053002344	active site
1407053002345	I-site; other site
1407053002346	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1407053002347	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1407053002348	Coenzyme A binding pocket [chemical binding]; other site
1407053002349	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1407053002350	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1407053002351	active site residue [active]
1407053002352	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1407053002353	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
1407053002354	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
1407053002355	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
1407053002356	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1407053002357	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
1407053002358	catalytic residue [active]
1407053002359	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1407053002360	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1407053002361	ATP binding site [chemical binding]; other site
1407053002362	Mg++ binding site [ion binding]; other site
1407053002363	motif III; other site
1407053002364	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1407053002365	nucleotide binding region [chemical binding]; other site
1407053002366	ATP-binding site [chemical binding]; other site
1407053002367	threonine dehydratase; Validated; Region: PRK08639
1407053002368	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1407053002369	tetramer interface [polypeptide binding]; other site
1407053002370	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1407053002371	catalytic residue [active]
1407053002372	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
1407053002373	putative Ile/Val binding site [chemical binding]; other site
1407053002374	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
1407053002375	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1407053002376	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
1407053002377	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
1407053002378	putative MPT binding site; other site
1407053002379	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1407053002380	Ligand Binding Site [chemical binding]; other site
1407053002381	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1407053002382	active site
1407053002383	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666
1407053002384	nudix motif; other site
1407053002385	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1407053002386	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1407053002387	Beta-lactamase; Region: Beta-lactamase; pfam00144
1407053002388	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1407053002389	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1407053002390	PAS domain; Region: PAS_9; pfam13426
1407053002391	putative active site [active]
1407053002392	heme pocket [chemical binding]; other site
1407053002393	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1407053002394	PAS fold; Region: PAS_4; pfam08448
1407053002395	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1407053002396	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1407053002397	dimer interface [polypeptide binding]; other site
1407053002398	phosphorylation site [posttranslational modification]
1407053002399	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1407053002400	ATP binding site [chemical binding]; other site
1407053002401	Mg2+ binding site [ion binding]; other site
1407053002402	G-X-G motif; other site
1407053002403	Response regulator receiver domain; Region: Response_reg; pfam00072
1407053002404	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1407053002405	active site
1407053002406	phosphorylation site [posttranslational modification]
1407053002407	intermolecular recognition site; other site
1407053002408	dimerization interface [polypeptide binding]; other site
1407053002409	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
1407053002410	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
1407053002411	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1407053002412	catalytic core [active]
1407053002413	Predicted membrane protein [Function unknown]; Region: COG3768
1407053002414	Domain of unknown function (DUF697); Region: DUF697; cl12064
1407053002415	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1407053002416	catalytic center binding site [active]
1407053002417	ATP binding site [chemical binding]; other site
1407053002418	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
1407053002419	homooctamer interface [polypeptide binding]; other site
1407053002420	active site
1407053002421	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1407053002422	dihydropteroate synthase; Region: DHPS; TIGR01496
1407053002423	substrate binding pocket [chemical binding]; other site
1407053002424	dimer interface [polypeptide binding]; other site
1407053002425	inhibitor binding site; inhibition site
1407053002426	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1407053002427	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1407053002428	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1407053002429	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1407053002430	catalytic loop [active]
1407053002431	iron binding site [ion binding]; other site
1407053002432	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
1407053002433	ABC-type uncharacterized transport system, auxiliary component [General function prediction only]; Region: COG3218
1407053002434	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
1407053002435	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1407053002436	mce related protein; Region: MCE; pfam02470
1407053002437	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
1407053002438	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
1407053002439	Walker A/P-loop; other site
1407053002440	ATP binding site [chemical binding]; other site
1407053002441	Q-loop/lid; other site
1407053002442	ABC transporter signature motif; other site
1407053002443	Walker B; other site
1407053002444	D-loop; other site
1407053002445	H-loop/switch region; other site
1407053002446	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1407053002447	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1407053002448	Permease; Region: Permease; pfam02405
1407053002449	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
1407053002450	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
1407053002451	active site
1407053002452	malic enzyme; Reviewed; Region: PRK12862
1407053002453	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1407053002454	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
1407053002455	putative NAD(P) binding site [chemical binding]; other site
1407053002456	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
1407053002457	glutamyl-tRNA synthetase; Provisional; Region: PRK12558
1407053002458	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1407053002459	active site
1407053002460	HIGH motif; other site
1407053002461	nucleotide binding site [chemical binding]; other site
1407053002462	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1407053002463	active site
1407053002464	KMSKS motif; other site
1407053002465	NAD synthetase; Provisional; Region: PRK13981
1407053002466	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
1407053002467	multimer interface [polypeptide binding]; other site
1407053002468	active site
1407053002469	catalytic triad [active]
1407053002470	protein interface 1 [polypeptide binding]; other site
1407053002471	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1407053002472	homodimer interface [polypeptide binding]; other site
1407053002473	NAD binding pocket [chemical binding]; other site
1407053002474	ATP binding pocket [chemical binding]; other site
1407053002475	Mg binding site [ion binding]; other site
1407053002476	active-site loop [active]
1407053002477	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
1407053002478	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
1407053002479	glutathione reductase; Validated; Region: PRK06116
1407053002480	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1407053002481	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1407053002482	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1407053002483	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
1407053002484	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1407053002485	active site
1407053002486	dimer interface [polypeptide binding]; other site
1407053002487	phosphoglycolate phosphatase; Provisional; Region: PRK13222
1407053002488	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1407053002489	motif II; other site
1407053002490	Uncharacterized conserved protein [Function unknown]; Region: COG0062
1407053002491	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1407053002492	putative substrate binding site [chemical binding]; other site
1407053002493	putative ATP binding site [chemical binding]; other site
1407053002494	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
1407053002495	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1407053002496	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1407053002497	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1407053002498	Chaperone required for the assembly of the mitochondrial F1-ATPase [Posttranslational modification, protein turnover, chaperones]; Region: COG5387
1407053002499	haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549
1407053002500	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1407053002501	motif I; other site
1407053002502	active site
1407053002503	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1407053002504	motif II; other site
1407053002505	EamA-like transporter family; Region: EamA; pfam00892
1407053002506	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1407053002507	EamA-like transporter family; Region: EamA; pfam00892
1407053002508	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1407053002509	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1407053002510	active site
1407053002511	cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657
1407053002512	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1407053002513	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1407053002514	Walker A/P-loop; other site
1407053002515	ATP binding site [chemical binding]; other site
1407053002516	Q-loop/lid; other site
1407053002517	ABC transporter signature motif; other site
1407053002518	Walker B; other site
1407053002519	D-loop; other site
1407053002520	H-loop/switch region; other site
1407053002521	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
1407053002522	putative hydrolase; Provisional; Region: PRK02113
1407053002523	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
1407053002524	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1407053002525	active site
1407053002526	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1407053002527	tRNA synthetases class I (M); Region: tRNA-synt_1g; pfam09334
1407053002528	active site
1407053002529	HIGH motif; other site
1407053002530	KMSKS motif; other site
1407053002531	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1407053002532	tRNA binding surface [nucleotide binding]; other site
1407053002533	anticodon binding site; other site
1407053002534	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
1407053002535	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1407053002536	TMP-binding site; other site
1407053002537	ATP-binding site [chemical binding]; other site
1407053002538	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1407053002539	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
1407053002540	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
1407053002541	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
1407053002542	ArsC family; Region: ArsC; pfam03960
1407053002543	catalytic residues [active]
1407053002544	Lysozyme family protein [General function prediction only]; Region: zliS; COG3926
1407053002545	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
1407053002546	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
1407053002547	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1407053002548	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1407053002549	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1407053002550	Phage portal protein; Region: Phage_portal; pfam04860
1407053002551	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
1407053002552	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1407053002553	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1407053002554	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
1407053002555	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
1407053002556	Domain of unknown function (DUF1508); Region: DUF1508; cl01356
1407053002557	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
1407053002558	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1407053002559	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1407053002560	active site
1407053002561	Int/Topo IB signature motif; other site
1407053002562	catalytic residues [active]
1407053002563	DNA binding site [nucleotide binding]
1407053002564	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
1407053002565	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1407053002566	fumarate hydratase; Provisional; Region: PRK15389
1407053002567	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
1407053002568	molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361
1407053002569	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1407053002570	FeS/SAM binding site; other site
1407053002571	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1407053002572	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
1407053002573	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
1407053002574	GTP binding site; other site
1407053002575	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
1407053002576	Walker A motif; other site
1407053002577	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1407053002578	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1407053002579	substrate binding pocket [chemical binding]; other site
1407053002580	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1407053002581	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1407053002582	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1407053002583	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1407053002584	HIGH motif; other site
1407053002585	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1407053002586	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1407053002587	active site
1407053002588	KMSKS motif; other site
1407053002589	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1407053002590	tRNA binding surface [nucleotide binding]; other site
1407053002591	anticodon binding site; other site
1407053002592	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1407053002593	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
1407053002594	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
1407053002595	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1407053002596	S-adenosylmethionine binding site [chemical binding]; other site
1407053002597	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
1407053002598	metal-binding site [ion binding]
1407053002599	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
1407053002600	helicase 45; Provisional; Region: PTZ00424
1407053002601	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1407053002602	ATP binding site [chemical binding]; other site
1407053002603	Mg++ binding site [ion binding]; other site
1407053002604	motif III; other site
1407053002605	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1407053002606	nucleotide binding region [chemical binding]; other site
1407053002607	ATP-binding site [chemical binding]; other site
1407053002608	ATP-NAD kinase; Region: NAD_kinase; pfam01513
1407053002609	inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761
1407053002610	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1407053002611	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1407053002612	active site
1407053002613	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
1407053002614	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
1407053002615	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1407053002616	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1407053002617	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1407053002618	catalytic residue [active]
1407053002619	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
1407053002620	FeS assembly protein SufD; Region: sufD; TIGR01981
1407053002621	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
1407053002622	putative ABC transporter; Region: ycf24; CHL00085
1407053002623	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
1407053002624	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
1407053002625	Predicted molecular chaperone distantly related to HSP70-fold metalloproteases [Posttranslational modification, protein turnover, chaperones]; Region: COG2377
1407053002626	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1407053002627	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1407053002628	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1407053002629	catalytic triad [active]
1407053002630	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
1407053002631	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1407053002632	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1407053002633	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1407053002634	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1407053002635	AMIN domain; Region: AMIN; pfam11741
1407053002636	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1407053002637	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1407053002638	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
1407053002639	aspartate aminotransferase; Provisional; Region: PRK05764
1407053002640	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1407053002641	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1407053002642	homodimer interface [polypeptide binding]; other site
1407053002643	catalytic residue [active]
1407053002644	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
1407053002645	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
1407053002646	catalytic residues [active]
1407053002647	Dehydroquinase class II; Region: DHquinase_II; pfam01220
1407053002648	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
1407053002649	trimer interface [polypeptide binding]; other site
1407053002650	active site
1407053002651	dimer interface [polypeptide binding]; other site
1407053002652	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
1407053002653	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1407053002654	carboxyltransferase (CT) interaction site; other site
1407053002655	biotinylation site [posttranslational modification]; other site
1407053002656	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1407053002657	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1407053002658	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1407053002659	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1407053002660	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
1407053002661	NADH dehydrogenase; Validated; Region: PRK08183
1407053002662	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1407053002663	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1407053002664	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1407053002665	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1407053002666	GatB domain; Region: GatB_Yqey; smart00845
1407053002667	trigger factor; Provisional; Region: tig; PRK01490
1407053002668	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1407053002669	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1407053002670	Uncharacterized membrane-anchored protein [Function unknown]; Region: COG4929
1407053002671	Predicted membrane protein (DUF2157); Region: DUF2157; cl10480
1407053002672	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
1407053002673	Glucose inhibited division protein A; Region: GIDA; pfam01134
1407053002674	Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562
1407053002675	substrate binding pocket [chemical binding]; other site
1407053002676	substrate-Mg2+ binding site; other site
1407053002677	aspartate-rich region 1; other site
1407053002678	aspartate-rich region 2; other site
1407053002679	Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248
1407053002680	Preprotein translocase subunit SecF [Intracellular trafficking and secretion]; Region: SecF; COG0341
1407053002681	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
1407053002682	Protein export membrane protein; Region: SecD_SecF; pfam02355
1407053002683	Preprotein translocase subunit YajC [Intracellular trafficking and secretion]; Region: YajC; COG1862
1407053002684	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
1407053002685	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1407053002686	Walker A motif; other site
1407053002687	ATP binding site [chemical binding]; other site
1407053002688	Walker B motif; other site
1407053002689	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1407053002690	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1407053002691	Peptidase family M23; Region: Peptidase_M23; pfam01551
1407053002692	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
1407053002693	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1407053002694	S-adenosylmethionine binding site [chemical binding]; other site
1407053002695	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
1407053002696	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
1407053002697	sec-independent translocase; Provisional; Region: PRK00708
1407053002698	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
1407053002699	twin arginine translocase protein A; Provisional; Region: tatA; PRK00720
1407053002700	Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386
1407053002701	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
1407053002702	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1407053002703	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
1407053002704	Sporulation related domain; Region: SPOR; pfam05036
1407053002705	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
1407053002706	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
1407053002707	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
1407053002708	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
1407053002709	putative catalytic site [active]
1407053002710	putative phosphate binding site [ion binding]; other site
1407053002711	active site
1407053002712	metal binding site A [ion binding]; metal-binding site
1407053002713	DNA binding site [nucleotide binding]
1407053002714	putative AP binding site [nucleotide binding]; other site
1407053002715	putative metal binding site B [ion binding]; other site
1407053002716	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1407053002717	Sel1-like repeats; Region: SEL1; smart00671
1407053002718	Staphylococcal nuclease homologues; Region: SNc; smart00318
1407053002719	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
1407053002720	Catalytic site; other site
1407053002721	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
1407053002722	putative uracil binding site [chemical binding]; other site
1407053002723	putative active site [active]
1407053002724	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1407053002725	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1407053002726	putative DNA binding site [nucleotide binding]; other site
1407053002727	putative Zn2+ binding site [ion binding]; other site
1407053002728	AsnC family; Region: AsnC_trans_reg; pfam01037
1407053002729	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
1407053002730	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
1407053002731	putative dimer interface [polypeptide binding]; other site
1407053002732	active site pocket [active]
1407053002733	putative cataytic base [active]
1407053002734	cobalamin synthase; Reviewed; Region: cobS; PRK00235
1407053002735	Predicted aspartyl protease [General function prediction only]; Region: COG3577
1407053002736	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
1407053002737	catalytic motif [active]
1407053002738	Catalytic residue [active]
1407053002739	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
1407053002740	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1407053002741	FMN binding site [chemical binding]; other site
1407053002742	active site
1407053002743	catalytic residues [active]
1407053002744	substrate binding site [chemical binding]; other site
1407053002745	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
1407053002746	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1407053002747	substrate binding pocket [chemical binding]; other site
1407053002748	membrane-bound complex binding site; other site
1407053002749	hinge residues; other site
1407053002750	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
1407053002751	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1407053002752	active site
1407053002753	motif I; other site
1407053002754	motif II; other site
1407053002755	putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223
1407053002756	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1407053002757	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1407053002758	substrate binding site [chemical binding]; other site
1407053002759	ATP binding site [chemical binding]; other site
1407053002760	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
1407053002761	active site
1407053002762	catalytic residues [active]
1407053002763	Lysozyme family protein [General function prediction only]; Region: zliS; COG3926
1407053002764	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
1407053002765	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
1407053002766	acyl carrier protein; Provisional; Region: PRK06508
1407053002767	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519
1407053002768	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
1407053002769	active site
1407053002770	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501
1407053002771	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1407053002772	dimer interface [polypeptide binding]; other site
1407053002773	active site
1407053002774	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1407053002775	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266
1407053002776	putative NAD(P) binding site [chemical binding]; other site
1407053002777	structural Zn binding site [ion binding]; other site
1407053002778	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
1407053002779	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1407053002780	putative acyl-acceptor binding pocket; other site
1407053002781	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
1407053002782	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1407053002783	substrate binding site [chemical binding]; other site
1407053002784	hexamer interface [polypeptide binding]; other site
1407053002785	metal binding site [ion binding]; metal-binding site
1407053002786	adenylosuccinate lyase; Provisional; Region: PRK07492
1407053002787	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
1407053002788	tetramer interface [polypeptide binding]; other site
1407053002789	active site
1407053002790	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
1407053002791	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1407053002792	putative metal binding site [ion binding]; other site
1407053002793	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
1407053002794	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1407053002795	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
1407053002796	Uncharacterized conserved protein [Function unknown]; Region: COG5467
1407053002797	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
1407053002798	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
1407053002799	ATP binding site [chemical binding]; other site
1407053002800	active site
1407053002801	substrate binding site [chemical binding]; other site
1407053002802	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
1407053002803	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
1407053002804	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1407053002805	putative active site [active]
1407053002806	catalytic triad [active]
1407053002807	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1407053002808	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
1407053002809	C-terminal domain interface [polypeptide binding]; other site
1407053002810	GSH binding site (G-site) [chemical binding]; other site
1407053002811	dimer interface [polypeptide binding]; other site
1407053002812	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
1407053002813	N-terminal domain interface [polypeptide binding]; other site
1407053002814	dimer interface [polypeptide binding]; other site
1407053002815	substrate binding pocket (H-site) [chemical binding]; other site
1407053002816	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1407053002817	dimerization interface [polypeptide binding]; other site
1407053002818	ATP binding site [chemical binding]; other site
1407053002819	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
1407053002820	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
1407053002821	putative GSH binding site [chemical binding]; other site
1407053002822	catalytic residues [active]
1407053002823	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
1407053002824	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1407053002825	putative substrate translocation pore; other site
1407053002826	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1407053002827	PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517
1407053002828	active site
1407053002829	putative lithium-binding site [ion binding]; other site
1407053002830	substrate binding site [chemical binding]; other site
1407053002831	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
1407053002832	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
1407053002833	Ligand Binding Site [chemical binding]; other site
1407053002834	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1407053002835	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1407053002836	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1407053002837	RNA binding surface [nucleotide binding]; other site
1407053002838	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921
1407053002839	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
1407053002840	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
1407053002841	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1407053002842	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1407053002843	Walker A/P-loop; other site
1407053002844	ATP binding site [chemical binding]; other site
1407053002845	Q-loop/lid; other site
1407053002846	ABC transporter signature motif; other site
1407053002847	Walker B; other site
1407053002848	D-loop; other site
1407053002849	H-loop/switch region; other site
1407053002850	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
1407053002851	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1407053002852	FtsX-like permease family; Region: FtsX; pfam02687
1407053002853	prolyl-tRNA synthetase; Provisional; Region: PRK12325
1407053002854	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1407053002855	dimer interface [polypeptide binding]; other site
1407053002856	motif 1; other site
1407053002857	active site
1407053002858	motif 2; other site
1407053002859	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1407053002860	active site
1407053002861	motif 3; other site
1407053002862	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1407053002863	anticodon binding site; other site
1407053002864	Predicted secreted protein [Function unknown]; Region: COG5454
1407053002865	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1407053002866	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
1407053002867	dimer interface [polypeptide binding]; other site
1407053002868	substrate binding site [chemical binding]; other site
1407053002869	metal binding site [ion binding]; metal-binding site
1407053002870	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
1407053002871	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
1407053002872	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
1407053002873	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
1407053002874	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1407053002875	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
1407053002876	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1407053002877	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
1407053002878	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
1407053002879	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1407053002880	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
1407053002881	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
1407053002882	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
1407053002883	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
1407053002884	4Fe-4S binding domain; Region: Fer4; pfam00037
1407053002885	4Fe-4S binding domain; Region: Fer4; pfam00037
1407053002886	NADH dehydrogenase subunit G; Validated; Region: PRK09130
1407053002887	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1407053002888	catalytic loop [active]
1407053002889	iron binding site [ion binding]; other site
1407053002890	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
1407053002891	MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773
1407053002892	Domain of unknown function (DUF1982); Region: DUF1982; pfam09326
1407053002893	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
1407053002894	SLBB domain; Region: SLBB; pfam10531
1407053002895	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
1407053002896	NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905
1407053002897	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
1407053002898	putative dimer interface [polypeptide binding]; other site
1407053002899	[2Fe-2S] cluster binding site [ion binding]; other site
1407053002900	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
1407053002901	NADH dehydrogenase subunit D; Validated; Region: PRK06075
1407053002902	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
1407053002903	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
1407053002904	NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377
1407053002905	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
1407053002906	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1407053002907	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1407053002908	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1407053002909	CoenzymeA binding site [chemical binding]; other site
1407053002910	subunit interaction site [polypeptide binding]; other site
1407053002911	PHB binding site; other site
1407053002912	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cl00333
1407053002913	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1407053002914	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
1407053002915	oligomer interface [polypeptide binding]; other site
1407053002916	putative active site [active]
1407053002917	Mn binding site [ion binding]; other site
1407053002918	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
1407053002919	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
1407053002920	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
1407053002921	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
1407053002922	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
1407053002923	SLBB domain; Region: SLBB; pfam10531
1407053002924	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
1407053002925	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
1407053002926	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
1407053002927	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1407053002928	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1407053002929	DNA binding residues [nucleotide binding]
1407053002930	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1407053002931	IHF dimer interface [polypeptide binding]; other site
1407053002932	IHF - DNA interface [nucleotide binding]; other site
1407053002933	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1407053002934	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1407053002935	dimer interface [polypeptide binding]; other site
1407053002936	active site
1407053002937	CoA binding pocket [chemical binding]; other site
1407053002938	putative phosphate acyltransferase; Provisional; Region: PRK05331
1407053002939	Uncharacterized conserved protein [Function unknown]; Region: COG5452
1407053002940	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
1407053002941	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
1407053002942	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
1407053002943	putative RNA binding site [nucleotide binding]; other site
1407053002944	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1407053002945	homopentamer interface [polypeptide binding]; other site
1407053002946	active site
1407053002947	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
1407053002948	Lumazine binding domain; Region: Lum_binding; pfam00677
1407053002949	Lumazine binding domain; Region: Lum_binding; pfam00677
1407053002950	Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes.  All members...; Region: cytidine_deaminase-like; cl00269
1407053002951	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
1407053002952	RibD C-terminal domain; Region: RibD_C; cl17279
1407053002953	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
1407053002954	ATP cone domain; Region: ATP-cone; pfam03477
1407053002955	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1407053002956	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1407053002957	dimer interface [polypeptide binding]; other site
1407053002958	active site
1407053002959	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1407053002960	folate binding site [chemical binding]; other site
1407053002961	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
1407053002962	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1407053002963	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1407053002964	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1407053002965	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1407053002966	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1407053002967	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
1407053002968	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1407053002969	substrate binding site [chemical binding]; other site
1407053002970	oxyanion hole (OAH) forming residues; other site
1407053002971	trimer interface [polypeptide binding]; other site
1407053002972	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
1407053002973	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
1407053002974	dimer interface [polypeptide binding]; other site
1407053002975	allosteric magnesium binding site [ion binding]; other site
1407053002976	active site
1407053002977	aspartate-rich active site metal binding site; other site
1407053002978	Schiff base residues; other site
1407053002979	Predicted membrane protein/domain [Function unknown]; Region: COG1714
1407053002980	Putative arginyl-tRNA:protein arginylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG2935
1407053002981	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
1407053002982	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
1407053002983	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1407053002984	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1407053002985	dimer interface [polypeptide binding]; other site
1407053002986	anticodon binding site; other site
1407053002987	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1407053002988	homodimer interface [polypeptide binding]; other site
1407053002989	motif 1; other site
1407053002990	active site
1407053002991	motif 2; other site
1407053002992	GAD domain; Region: GAD; pfam02938
1407053002993	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1407053002994	active site
1407053002995	motif 3; other site
1407053002996	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
1407053002997	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
1407053002998	catalytic site [active]
1407053002999	putative active site [active]
1407053003000	putative substrate binding site [chemical binding]; other site
1407053003001	HRDC domain; Region: HRDC; pfam00570
1407053003002	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
1407053003003	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1407053003004	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391
1407053003005	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1407053003006	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1407053003007	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1407053003008	Walker A/P-loop; other site
1407053003009	ATP binding site [chemical binding]; other site
1407053003010	Q-loop/lid; other site
1407053003011	ABC transporter signature motif; other site
1407053003012	Walker B; other site
1407053003013	D-loop; other site
1407053003014	H-loop/switch region; other site
1407053003015	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
1407053003016	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053003017	conserved gate region; other site
1407053003018	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053003019	putative PBP binding loops; other site
1407053003020	dimer interface [polypeptide binding]; other site
1407053003021	ABC-ATPase subunit interface; other site
1407053003022	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
1407053003023	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1407053003024	substrate binding pocket [chemical binding]; other site
1407053003025	membrane-bound complex binding site; other site
1407053003026	hinge residues; other site
1407053003027	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
1407053003028	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1407053003029	active site
1407053003030	cystathionine beta-lyase; Provisional; Region: PRK05967
1407053003031	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1407053003032	homodimer interface [polypeptide binding]; other site
1407053003033	substrate-cofactor binding pocket; other site
1407053003034	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1407053003035	catalytic residue [active]
1407053003036	Bacterial SH3 domain; Region: SH3_3; pfam08239
1407053003037	Uncharacterized protein containing a TIR (Toll-Interleukin 1-resistance) domain [Function unknown]; Region: COG4916
1407053003038	TIR domain; Region: TIR_2; pfam13676
1407053003039	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1407053003040	AAA domain; Region: AAA_22; pfam13401
1407053003041	AAA ATPase domain; Region: AAA_16; pfam13191
1407053003042	Integrase core domain; Region: rve; pfam00665
1407053003043	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
1407053003044	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1407053003045	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
1407053003046	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1407053003047	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1407053003048	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1407053003049	non-specific DNA binding site [nucleotide binding]; other site
1407053003050	salt bridge; other site
1407053003051	sequence-specific DNA binding site [nucleotide binding]; other site
1407053003052	Uncharacterized conserved protein [Function unknown]; Region: COG4933
1407053003053	Archaeal adenylate kinase [Nucleotide transport and metabolism]; Region: AdkA; COG2019
1407053003054	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
1407053003055	active site
1407053003056	catalytic site [active]
1407053003057	substrate binding site [chemical binding]; other site
1407053003058	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
1407053003059	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
1407053003060	L-lactate permease; Region: Lactate_perm; cl00701
1407053003061	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
1407053003062	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
1407053003063	putative NAD(P) binding site [chemical binding]; other site
1407053003064	putative active site [active]
1407053003065	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1407053003066	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1407053003067	NAD(P) binding site [chemical binding]; other site
1407053003068	active site
1407053003069	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1407053003070	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1407053003071	dimerization interface [polypeptide binding]; other site
1407053003072	putative ATP binding site [chemical binding]; other site
1407053003073	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
1407053003074	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1407053003075	active site
1407053003076	substrate binding site [chemical binding]; other site
1407053003077	cosubstrate binding site; other site
1407053003078	catalytic site [active]
1407053003079	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
1407053003080	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
1407053003081	putative [4Fe-4S] binding site [ion binding]; other site
1407053003082	putative molybdopterin cofactor binding site [chemical binding]; other site
1407053003083	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
1407053003084	putative molybdopterin cofactor binding site; other site
1407053003085	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
1407053003086	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
1407053003087	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1407053003088	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
1407053003089	putative C-terminal domain interface [polypeptide binding]; other site
1407053003090	putative GSH binding site (G-site) [chemical binding]; other site
1407053003091	putative dimer interface [polypeptide binding]; other site
1407053003092	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
1407053003093	dimer interface [polypeptide binding]; other site
1407053003094	N-terminal domain interface [polypeptide binding]; other site
1407053003095	putative substrate binding pocket (H-site) [chemical binding]; other site
1407053003096	short chain dehydrogenase; Provisional; Region: PRK09134
1407053003097	pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357
1407053003098	NADP binding site [chemical binding]; other site
1407053003099	substrate binding pocket [chemical binding]; other site
1407053003100	active site
1407053003101	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1407053003102	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1407053003103	GIY-YIG motif/motif A; other site
1407053003104	active site
1407053003105	catalytic site [active]
1407053003106	putative DNA binding site [nucleotide binding]; other site
1407053003107	metal binding site [ion binding]; metal-binding site
1407053003108	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1407053003109	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
1407053003110	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
1407053003111	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
1407053003112	MoaE interaction surface [polypeptide binding]; other site
1407053003113	MoeB interaction surface [polypeptide binding]; other site
1407053003114	thiocarboxylated glycine; other site
1407053003115	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1407053003116	MoaE homodimer interface [polypeptide binding]; other site
1407053003117	MoaD interaction [polypeptide binding]; other site
1407053003118	active site residues [active]
1407053003119	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126
1407053003120	Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187
1407053003121	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1407053003122	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
1407053003123	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1407053003124	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1407053003125	active site
1407053003126	multimer interface [polypeptide binding]; other site
1407053003127	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318
1407053003128	DinB superfamily; Region: DinB_2; pfam12867
1407053003129	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1407053003130	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1407053003131	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1407053003132	ABC transporter; Region: ABC_tran_2; pfam12848
1407053003133	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1407053003134	DNA polymerase III subunit chi; Validated; Region: PRK05728
1407053003135	multifunctional aminopeptidase A; Provisional; Region: PRK00913
1407053003136	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1407053003137	interface (dimer of trimers) [polypeptide binding]; other site
1407053003138	Substrate-binding/catalytic site; other site
1407053003139	Zn-binding sites [ion binding]; other site
1407053003140	Predicted permeases [General function prediction only]; Region: COG0795
1407053003141	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
1407053003142	Predicted permeases [General function prediction only]; Region: COG0795
1407053003143	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
1407053003144	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
1407053003145	OstA-like protein; Region: OstA; cl00844
1407053003146	Organic solvent tolerance protein; Region: OstA_C; pfam04453
1407053003147	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
1407053003148	SurA N-terminal domain; Region: SurA_N; pfam09312
1407053003149	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312
1407053003150	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
1407053003151	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1407053003152	Peptidase family M23; Region: Peptidase_M23; pfam01551
1407053003153	Predicted permeases [General function prediction only]; Region: RarD; COG2962
1407053003154	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
1407053003155	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
1407053003156	active site
1407053003157	metal binding site [ion binding]; metal-binding site
1407053003158	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
1407053003159	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1407053003160	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1407053003161	active site
1407053003162	HIGH motif; other site
1407053003163	nucleotide binding site [chemical binding]; other site
1407053003164	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1407053003165	KMSKS motif; other site
1407053003166	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1407053003167	Lysine efflux permease [General function prediction only]; Region: COG1279
1407053003168	Uncharacterized conserved protein [Function unknown]; Region: COG2135
1407053003169	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673
1407053003170	nudix motif; other site
1407053003171	dihydroorotase; Validated; Region: PRK09060
1407053003172	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1407053003173	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
1407053003174	active site
1407053003175	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
1407053003176	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
1407053003177	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1407053003178	Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896
1407053003179	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350
1407053003180	Recombination protein O N terminal; Region: RecO_N; pfam11967
1407053003181	DNA repair protein RecO; Region: reco; TIGR00613
1407053003182	Recombination protein O C terminal; Region: RecO_C; pfam02565
1407053003183	GTPase Era; Reviewed; Region: era; PRK00089
1407053003184	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1407053003185	G1 box; other site
1407053003186	GTP/Mg2+ binding site [chemical binding]; other site
1407053003187	Switch I region; other site
1407053003188	G2 box; other site
1407053003189	Switch II region; other site
1407053003190	G3 box; other site
1407053003191	G4 box; other site
1407053003192	G5 box; other site
1407053003193	KH domain; Region: KH_2; pfam07650
1407053003194	ribonuclease III; Reviewed; Region: PRK12371
1407053003195	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1407053003196	dimerization interface [polypeptide binding]; other site
1407053003197	active site
1407053003198	metal binding site [ion binding]; metal-binding site
1407053003199	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1407053003200	dsRNA binding site [nucleotide binding]; other site
1407053003201	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1407053003202	Catalytic site [active]
1407053003203	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
1407053003204	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1407053003205	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
1407053003206	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1407053003207	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1407053003208	Helix-turn-helix domain; Region: HTH_18; pfam12833
1407053003209	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1407053003210	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1407053003211	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1407053003212	putative substrate translocation pore; other site
1407053003213	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1407053003214	active site
1407053003215	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
1407053003216	Uncharacterized conserved protein [Function unknown]; Region: COG1432
1407053003217	LabA_like proteins; Region: LabA; cd10911
1407053003218	putative metal binding site [ion binding]; other site
1407053003219	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1407053003220	SmpB-tmRNA interface; other site
1407053003221	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1407053003222	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1407053003223	dimer interface [polypeptide binding]; other site
1407053003224	active site
1407053003225	catalytic residue [active]
1407053003226	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1407053003227	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1407053003228	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1407053003229	catalytic residue [active]
1407053003230	Uncharacterized conserved protein [Function unknown]; Region: COG3743
1407053003231	Porin subfamily; Region: Porin_2; pfam02530
1407053003232	Porin subfamily; Region: Porin_2; pfam02530
1407053003233	histidinol-phosphate aminotransferase; Provisional; Region: PRK08153
1407053003234	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1407053003235	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1407053003236	homodimer interface [polypeptide binding]; other site
1407053003237	catalytic residue [active]
1407053003238	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1407053003239	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4731
1407053003240	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
1407053003241	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
1407053003242	C-terminal domain interface [polypeptide binding]; other site
1407053003243	GSH binding site (G-site) [chemical binding]; other site
1407053003244	dimer interface [polypeptide binding]; other site
1407053003245	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
1407053003246	N-terminal domain interface [polypeptide binding]; other site
1407053003247	putative dimer interface [polypeptide binding]; other site
1407053003248	active site
1407053003249	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3021
1407053003250	putative catalytic site [active]
1407053003251	putative metal binding site [ion binding]; other site
1407053003252	putative phosphate binding site [ion binding]; other site
1407053003253	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
1407053003254	Fe-S cluster binding site [ion binding]; other site
1407053003255	active site
1407053003256	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1407053003257	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1407053003258	putative substrate translocation pore; other site
1407053003259	EamA-like transporter family; Region: EamA; pfam00892
1407053003260	aminopeptidase N; Provisional; Region: pepN; PRK14015
1407053003261	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
1407053003262	active site
1407053003263	Zn binding site [ion binding]; other site
1407053003264	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1407053003265	PAS fold; Region: PAS_3; pfam08447
1407053003266	putative active site [active]
1407053003267	heme pocket [chemical binding]; other site
1407053003268	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1407053003269	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1407053003270	dimer interface [polypeptide binding]; other site
1407053003271	phosphorylation site [posttranslational modification]
1407053003272	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1407053003273	ATP binding site [chemical binding]; other site
1407053003274	Mg2+ binding site [ion binding]; other site
1407053003275	G-X-G motif; other site
1407053003276	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108
1407053003277	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1407053003278	metal binding triad; other site
1407053003279	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1407053003280	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1407053003281	metal binding triad; other site
1407053003282	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1407053003283	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1407053003284	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1407053003285	active site
1407053003286	phosphorylation site [posttranslational modification]
1407053003287	intermolecular recognition site; other site
1407053003288	dimerization interface [polypeptide binding]; other site
1407053003289	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1407053003290	DNA binding site [nucleotide binding]
1407053003291	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1407053003292	protein binding site [polypeptide binding]; other site
1407053003293	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1407053003294	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1407053003295	protein binding site [polypeptide binding]; other site
1407053003296	Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088
1407053003297	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
1407053003298	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
1407053003299	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
1407053003300	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
1407053003301	Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520
1407053003302	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1407053003303	HAMP domain; Region: HAMP; pfam00672
1407053003304	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1407053003305	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1407053003306	active site
1407053003307	phosphorylation site [posttranslational modification]
1407053003308	intermolecular recognition site; other site
1407053003309	dimerization interface [polypeptide binding]; other site
1407053003310	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1407053003311	DNA binding site [nucleotide binding]
1407053003312	GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547
1407053003313	Putative phage tail protein; Region: Phage-tail_3; pfam13550
1407053003314	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1407053003315	putative phage cell wall peptidase, NlpC/P60 family; Region: phage_NlpC_fam; TIGR02219
1407053003316	Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931
1407053003317	phage conserved hypothetical protein BR0599; Region: phg_TIGR02218
1407053003318	Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356
1407053003319	Protein of unknown function (DUF3356); Region: DUF3356; pfam11836
1407053003320	Predicted secreted protein [Function unknown]; Region: COG5437
1407053003321	Phage-related protein [Function unknown]; Region: COG4695
1407053003322	phage portal protein, HK97 family; Region: portal_HK97; TIGR01537
1407053003323	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1407053003324	Transglycosylase; Region: Transgly; cl17702
1407053003325	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
1407053003326	Predicted integral membrane protein [Function unknown]; Region: COG5436
1407053003327	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1407053003328	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
1407053003329	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1407053003330	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330
1407053003331	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
1407053003332	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1407053003333	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1407053003334	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1407053003335	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1407053003336	putative active site [active]
1407053003337	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1407053003338	heme pocket [chemical binding]; other site
1407053003339	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1407053003340	dimer interface [polypeptide binding]; other site
1407053003341	phosphorylation site [posttranslational modification]
1407053003342	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1407053003343	ATP binding site [chemical binding]; other site
1407053003344	Mg2+ binding site [ion binding]; other site
1407053003345	G-X-G motif; other site
1407053003346	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
1407053003347	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cl07055
1407053003348	DnaA box-binding interface [nucleotide binding]; other site
1407053003349	Predicted transcriptional regulator [Transcription]; Region: COG4957
1407053003350	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
1407053003351	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1407053003352	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
1407053003353	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1407053003354	motif II; other site
1407053003355	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
1407053003356	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1407053003357	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
1407053003358	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1407053003359	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1407053003360	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1407053003361	DNA-binding site [nucleotide binding]; DNA binding site
1407053003362	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1407053003363	putative addiction module antidote; Region: doc_partner; TIGR02609
1407053003364	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
1407053003365	transcription elongation factor regulatory protein; Validated; Region: PRK06342
1407053003366	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1407053003367	L-asparaginase II [Amino acid transport and metabolism]; Region: AnsA; COG4448
1407053003368	transcriptional regulator BetI; Validated; Region: PRK00767
1407053003369	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1407053003370	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1407053003371	choline dehydrogenase; Validated; Region: PRK02106
1407053003372	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1407053003373	betaine aldehyde dehydrogenase; Provisional; Region: PRK13252
1407053003374	NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090
1407053003375	tetrameric interface [polypeptide binding]; other site
1407053003376	NAD binding site [chemical binding]; other site
1407053003377	catalytic residues [active]
1407053003378	Helix-turn-helix domain; Region: HTH_18; pfam12833
1407053003379	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1407053003380	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1407053003381	DNA binding site [nucleotide binding]
1407053003382	domain linker motif; other site
1407053003383	Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
1407053003384	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1407053003385	putative ligand binding site [chemical binding]; other site
1407053003386	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1407053003387	nucleotide binding site [chemical binding]; other site
1407053003388	xylose isomerase; Provisional; Region: PRK05474
1407053003389	xylose isomerase; Region: xylose_isom_A; TIGR02630
1407053003390	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1407053003391	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1407053003392	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1407053003393	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1407053003394	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1407053003395	Metal-binding active site; metal-binding site
1407053003396	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
1407053003397	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1407053003398	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_3; cd06311
1407053003399	putative ligand binding site [chemical binding]; other site
1407053003400	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1407053003401	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1407053003402	TM-ABC transporter signature motif; other site
1407053003403	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1407053003404	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1407053003405	Walker A/P-loop; other site
1407053003406	ATP binding site [chemical binding]; other site
1407053003407	Q-loop/lid; other site
1407053003408	ABC transporter signature motif; other site
1407053003409	Walker B; other site
1407053003410	D-loop; other site
1407053003411	H-loop/switch region; other site
1407053003412	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1407053003413	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1407053003414	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795
1407053003415	putative ADP-binding pocket [chemical binding]; other site
1407053003416	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249
1407053003417	dimerization interface [polypeptide binding]; other site
1407053003418	putative active cleft [active]
1407053003419	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
1407053003420	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
1407053003421	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
1407053003422	Integrase core domain; Region: rve; pfam00665
1407053003423	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1407053003424	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1407053003425	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1407053003426	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
1407053003427	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1407053003428	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
1407053003429	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1407053003430	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1407053003431	Integrase core domain; Region: rve; pfam00665
1407053003432	DDE domain; Region: DDE_Tnp_IS240; pfam13610
1407053003433	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1407053003434	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
1407053003435	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
1407053003436	NADP-binding site; other site
1407053003437	homotetramer interface [polypeptide binding]; other site
1407053003438	substrate binding site [chemical binding]; other site
1407053003439	homodimer interface [polypeptide binding]; other site
1407053003440	active site
1407053003441	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
1407053003442	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1407053003443	inhibitor-cofactor binding pocket; inhibition site
1407053003444	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1407053003445	catalytic residue [active]
1407053003446	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
1407053003447	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1407053003448	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1407053003449	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
1407053003450	Walker A/P-loop; other site
1407053003451	ATP binding site [chemical binding]; other site
1407053003452	Q-loop/lid; other site
1407053003453	ABC transporter signature motif; other site
1407053003454	Walker B; other site
1407053003455	D-loop; other site
1407053003456	H-loop/switch region; other site
1407053003457	HTH-like domain; Region: HTH_21; pfam13276
1407053003458	Integrase core domain; Region: rve; pfam00665
1407053003459	Integrase core domain; Region: rve_3; pfam13683
1407053003460	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1407053003461	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1407053003462	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
1407053003463	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
1407053003464	Mg++ binding site [ion binding]; other site
1407053003465	putative catalytic motif [active]
1407053003466	putative substrate binding site [chemical binding]; other site
1407053003467	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
1407053003468	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
1407053003469	NAD(P) binding site [chemical binding]; other site
1407053003470	homodimer interface [polypeptide binding]; other site
1407053003471	substrate binding site [chemical binding]; other site
1407053003472	active site
1407053003473	Protein of unknown function (DUF2793); Region: DUF2793; pfam10983
1407053003474	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
1407053003475	active site
1407053003476	homotetramer interface [polypeptide binding]; other site
1407053003477	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
1407053003478	ureidoglycolate hydrolase; Provisional; Region: PRK03606
1407053003479	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
1407053003480	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1407053003481	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1407053003482	Putative catalytic NodB homology domain of uncharacterized BH0857 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH0857_like; cd10955
1407053003483	NodB motif; other site
1407053003484	putative active site [active]
1407053003485	putative catalytic site [active]
1407053003486	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1407053003487	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1407053003488	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1407053003489	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
1407053003490	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1407053003491	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1407053003492	ABC transporter signature motif; other site
1407053003493	Walker B; other site
1407053003494	D-loop; other site
1407053003495	H-loop/switch region; other site
1407053003496	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1407053003497	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
1407053003498	catalytic residues [active]
1407053003499	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
1407053003500	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1407053003501	minor groove reading motif; other site
1407053003502	helix-hairpin-helix signature motif; other site
1407053003503	substrate binding pocket [chemical binding]; other site
1407053003504	active site
1407053003505	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
1407053003506	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
1407053003507	DNA binding and oxoG recognition site [nucleotide binding]
1407053003508	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
1407053003509	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1407053003510	motif II; other site
1407053003511	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
1407053003512	DNA methylase; Region: N6_N4_Mtase; pfam01555
1407053003513	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1407053003514	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
1407053003515	dimer interface [polypeptide binding]; other site
1407053003516	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1407053003517	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
1407053003518	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1407053003519	active site
1407053003520	motif I; other site
1407053003521	motif II; other site
1407053003522	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
1407053003523	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
1407053003524	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1407053003525	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
1407053003526	catalytic residue [active]
1407053003527	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1407053003528	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1407053003529	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1407053003530	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1407053003531	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1407053003532	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
1407053003533	PAS fold; Region: PAS_3; pfam08447
1407053003534	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1407053003535	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1407053003536	metal binding site [ion binding]; metal-binding site
1407053003537	active site
1407053003538	I-site; other site
1407053003539	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1407053003540	hypothetical protein; Validated; Region: PRK00228
1407053003541	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
1407053003542	catalytic triad [active]
1407053003543	dimer interface [polypeptide binding]; other site
1407053003544	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
1407053003545	RNA/DNA hybrid binding site [nucleotide binding]; other site
1407053003546	active site
1407053003547	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
1407053003548	Phosphotransferase enzyme family; Region: APH; pfam01636
1407053003549	putative active site [active]
1407053003550	putative substrate binding site [chemical binding]; other site
1407053003551	ATP binding site [chemical binding]; other site
1407053003552	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
1407053003553	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
1407053003554	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
1407053003555	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349
1407053003556	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
1407053003557	Subunit III/VIIa interface [polypeptide binding]; other site
1407053003558	Phospholipid binding site [chemical binding]; other site
1407053003559	Subunit I/III interface [polypeptide binding]; other site
1407053003560	Subunit III/VIb interface [polypeptide binding]; other site
1407053003561	Subunit III/VIa interface; other site
1407053003562	Subunit III/Vb interface [polypeptide binding]; other site
1407053003563	Cytochrome oxidase assembly factor [Posttranslational modification, protein turnover, chaperones]; Region: COX11; COG3175
1407053003564	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
1407053003565	UbiA prenyltransferase family; Region: UbiA; pfam01040
1407053003566	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1407053003567	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
1407053003568	Subunit I/VIa interface [polypeptide binding]; other site
1407053003569	Subunit I/III interface [polypeptide binding]; other site
1407053003570	Dimer interface; other site
1407053003571	Subunit I/II interface [polypeptide binding]; other site
1407053003572	Putative water exit pathway; other site
1407053003573	Binuclear center (heme a3/CuB) [ion binding]; other site
1407053003574	K-pathway; other site
1407053003575	Subunit I/Vb interface [polypeptide binding]; other site
1407053003576	Putative proton exit pathway; other site
1407053003577	Subunit I/VIb interface; other site
1407053003578	Subunit I/VIc interface [polypeptide binding]; other site
1407053003579	Electron transfer pathway; other site
1407053003580	Low-spin heme (heme a) binding site [chemical binding]; other site
1407053003581	Subunit I/IV interface [polypeptide binding]; other site
1407053003582	Subunit I/VIIIb interface [polypeptide binding]; other site
1407053003583	Subunit I/VIIb interface [polypeptide binding]; other site
1407053003584	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
1407053003585	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
1407053003586	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1407053003587	Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342
1407053003588	protease TldD; Provisional; Region: tldD; PRK10735
1407053003589	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1407053003590	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1407053003591	catalytic site [active]
1407053003592	G-X2-G-X-G-K; other site
1407053003593	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
1407053003594	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
1407053003595	dimerization interface [polypeptide binding]; other site
1407053003596	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
1407053003597	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1407053003598	dimer interface [polypeptide binding]; other site
1407053003599	active site
1407053003600	acyl carrier protein; Provisional; Region: acpP; PRK00982
1407053003601	3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936
1407053003602	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1407053003603	NAD(P) binding site [chemical binding]; other site
1407053003604	homotetramer interface [polypeptide binding]; other site
1407053003605	homodimer interface [polypeptide binding]; other site
1407053003606	active site
1407053003607	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1407053003608	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1407053003609	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1407053003610	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
1407053003611	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1407053003612	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1407053003613	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1407053003614	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
1407053003615	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1407053003616	S-adenosylmethionine binding site [chemical binding]; other site
1407053003617	replicative DNA helicase; Provisional; Region: PRK09165
1407053003618	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1407053003619	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1407053003620	Walker A motif; other site
1407053003621	ATP binding site [chemical binding]; other site
1407053003622	Walker B motif; other site
1407053003623	DNA binding loops [nucleotide binding]
1407053003624	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
1407053003625	Colicin V production protein; Region: Colicin_V; pfam02674
1407053003626	amidophosphoribosyltransferase; Provisional; Region: PRK09123
1407053003627	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1407053003628	active site
1407053003629	tetramer interface [polypeptide binding]; other site
1407053003630	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1407053003631	active site
1407053003632	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
1407053003633	classical (c) SDRs; Region: SDR_c; cd05233
1407053003634	NAD(P) binding site [chemical binding]; other site
1407053003635	active site
1407053003636	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
1407053003637	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
1407053003638	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
1407053003639	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1407053003640	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
1407053003641	Q-loop/lid; other site
1407053003642	ABC transporter signature motif; other site
1407053003643	Walker B; other site
1407053003644	D-loop; other site
1407053003645	H-loop/switch region; other site
1407053003646	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
1407053003647	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1407053003648	Predicted periplasmic protein [General function prediction only]; Region: COG3895
1407053003649	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
1407053003650	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
1407053003651	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
1407053003652	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1407053003653	RNA binding surface [nucleotide binding]; other site
1407053003654	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1407053003655	S-adenosylmethionine binding site [chemical binding]; other site
1407053003656	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
1407053003657	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
1407053003658	TPP-binding site; other site
1407053003659	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1407053003660	PYR/PP interface [polypeptide binding]; other site
1407053003661	dimer interface [polypeptide binding]; other site
1407053003662	TPP binding site [chemical binding]; other site
1407053003663	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1407053003664	Pirin-related protein [General function prediction only]; Region: COG1741
1407053003665	Pirin; Region: Pirin; pfam02678
1407053003666	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
1407053003667	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3753
1407053003668	Predicted membrane protein [Function unknown]; Region: COG2261
1407053003669	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1407053003670	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1407053003671	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
1407053003672	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
1407053003673	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
1407053003674	putative active site [active]
1407053003675	Zn binding site [ion binding]; other site
1407053003676	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09314
1407053003677	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1407053003678	GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807
1407053003679	dimerization interface [polypeptide binding]; other site
1407053003680	active site
1407053003681	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1407053003682	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1407053003683	Tetramer interface [polypeptide binding]; other site
1407053003684	active site
1407053003685	FMN-binding site [chemical binding]; other site
1407053003686	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
1407053003687	putative acyl-acceptor binding pocket; other site
1407053003688	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1407053003689	DNA-binding site [nucleotide binding]; DNA binding site
1407053003690	RNA-binding motif; other site
1407053003691	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1407053003692	catalytic core [active]
1407053003693	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159
1407053003694	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
1407053003695	NAD binding site [chemical binding]; other site
1407053003696	homotetramer interface [polypeptide binding]; other site
1407053003697	homodimer interface [polypeptide binding]; other site
1407053003698	substrate binding site [chemical binding]; other site
1407053003699	active site
1407053003700	chaperone protein DnaJ; Provisional; Region: PRK14299
1407053003701	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1407053003702	HSP70 interaction site [polypeptide binding]; other site
1407053003703	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1407053003704	dimer interface [polypeptide binding]; other site
1407053003705	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
1407053003706	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1407053003707	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
1407053003708	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878
1407053003709	UbiA prenyltransferase family; Region: UbiA; pfam01040
1407053003710	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1407053003711	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1407053003712	metal binding site [ion binding]; metal-binding site
1407053003713	active site
1407053003714	I-site; other site
1407053003715	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1407053003716	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1407053003717	active site
1407053003718	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
1407053003719	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
1407053003720	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1407053003721	FAD binding domain; Region: FAD_binding_4; pfam01565
1407053003722	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1407053003723	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
1407053003724	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
1407053003725	DALR anticodon binding domain; Region: DALR_1; pfam05746
1407053003726	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
1407053003727	glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348
1407053003728	motif 1; other site
1407053003729	dimer interface [polypeptide binding]; other site
1407053003730	active site
1407053003731	motif 2; other site
1407053003732	motif 3; other site
1407053003733	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1407053003734	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1407053003735	substrate binding pocket [chemical binding]; other site
1407053003736	chain length determination region; other site
1407053003737	substrate-Mg2+ binding site; other site
1407053003738	catalytic residues [active]
1407053003739	aspartate-rich region 1; other site
1407053003740	active site lid residues [active]
1407053003741	aspartate-rich region 2; other site
1407053003742	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
1407053003743	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1407053003744	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560
1407053003745	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
1407053003746	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
1407053003747	tandem repeat interface [polypeptide binding]; other site
1407053003748	oligomer interface [polypeptide binding]; other site
1407053003749	active site residues [active]
1407053003750	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608
1407053003751	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1407053003752	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1407053003753	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1407053003754	active site
1407053003755	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
1407053003756	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1407053003757	FeS/SAM binding site; other site
1407053003758	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1407053003759	RNA/DNA hybrid binding site [nucleotide binding]; other site
1407053003760	active site
1407053003761	F0F1 ATP synthase subunit B; Validated; Region: PRK09173
1407053003762	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1407053003763	F0F1 ATP synthase subunit B'; Validated; Region: PRK09174
1407053003764	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1407053003765	F0F1 ATP synthase subunit C; Validated; Region: PRK07558
1407053003766	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1407053003767	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1407053003768	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5336
1407053003769	Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773
1407053003770	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
1407053003771	GTP-binding protein Der; Reviewed; Region: PRK00093
1407053003772	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1407053003773	G1 box; other site
1407053003774	GTP/Mg2+ binding site [chemical binding]; other site
1407053003775	Switch I region; other site
1407053003776	G2 box; other site
1407053003777	Switch II region; other site
1407053003778	G3 box; other site
1407053003779	G4 box; other site
1407053003780	G5 box; other site
1407053003781	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1407053003782	G1 box; other site
1407053003783	GTP/Mg2+ binding site [chemical binding]; other site
1407053003784	Switch I region; other site
1407053003785	G2 box; other site
1407053003786	G3 box; other site
1407053003787	Switch II region; other site
1407053003788	G4 box; other site
1407053003789	G5 box; other site
1407053003790	Putative catalytic domain of uncharacterized bacterial hypothetical proteins similar to insect chitin deacetylase-like proteins; Region: CE4_CDA_like_3; cd10976
1407053003791	NodB motif; other site
1407053003792	putative active site [active]
1407053003793	putative catalytic site [active]
1407053003794	microcin B17 transporter; Reviewed; Region: PRK11098
1407053003795	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1407053003796	putative substrate translocation pore; other site
1407053003797	D-galactonate transporter; Region: 2A0114; TIGR00893
1407053003798	Predicted membrane protein [Function unknown]; Region: COG4129
1407053003799	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1407053003800	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
1407053003801	ArsC family; Region: ArsC; pfam03960
1407053003802	putative catalytic residues [active]
1407053003803	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1407053003804	Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105
1407053003805	NAD(P) binding site [chemical binding]; other site
1407053003806	catalytic residues [active]
1407053003807	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
1407053003808	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1407053003809	catalytic residues [active]
1407053003810	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1407053003811	metal binding site 2 [ion binding]; metal-binding site
1407053003812	putative DNA binding helix; other site
1407053003813	metal binding site 1 [ion binding]; metal-binding site
1407053003814	dimer interface [polypeptide binding]; other site
1407053003815	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
1407053003816	Low-spin heme binding site [chemical binding]; other site
1407053003817	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
1407053003818	Putative water exit pathway; other site
1407053003819	Binuclear center (active site) [active]
1407053003820	Putative proton exit pathway; other site
1407053003821	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
1407053003822	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433
1407053003823	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324
1407053003824	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
1407053003825	Cytochrome c; Region: Cytochrom_C; pfam00034
1407053003826	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1407053003827	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
1407053003828	4Fe-4S binding domain; Region: Fer4_5; pfam12801
1407053003829	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
1407053003830	Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456
1407053003831	FixH; Region: FixH; pfam05751
1407053003832	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1407053003833	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1407053003834	metal-binding site [ion binding]
1407053003835	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597
1407053003836	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
1407053003837	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
1407053003838	MOFRL family; Region: MOFRL; pfam05161
1407053003839	guanine deaminase; Provisional; Region: PRK09228
1407053003840	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
1407053003841	active site
1407053003842	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1407053003843	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1407053003844	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1407053003845	putative effector binding pocket; other site
1407053003846	dimerization interface [polypeptide binding]; other site
1407053003847	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
1407053003848	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
1407053003849	XdhC Rossmann domain; Region: XdhC_C; pfam13478
1407053003850	Xanthine dehydrogenase, molybdopterin-binding subunit B [Nucleotide transport and metabolism]; Region: XdhB; COG4631
1407053003851	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1407053003852	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1407053003853	Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [Nucleotide transport and metabolism]; Region: XdhA; COG4630
1407053003854	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1407053003855	catalytic loop [active]
1407053003856	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1407053003857	iron binding site [ion binding]; other site
1407053003858	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1407053003859	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
1407053003860	hypothetical protein; Provisional; Region: PRK11171
1407053003861	Protein of unknown function (DUF861); Region: Cupin_3; pfam05899
1407053003862	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
1407053003863	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
1407053003864	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
1407053003865	TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665
1407053003866	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1407053003867	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1407053003868	active site
1407053003869	phosphorylation site [posttranslational modification]
1407053003870	intermolecular recognition site; other site
1407053003871	dimerization interface [polypeptide binding]; other site
1407053003872	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1407053003873	DNA binding residues [nucleotide binding]
1407053003874	dimerization interface [polypeptide binding]; other site
1407053003875	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564
1407053003876	Cache domain; Region: Cache_2; pfam08269
1407053003877	Histidine kinase; Region: HisKA_3; pfam07730
1407053003878	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1407053003879	ATP binding site [chemical binding]; other site
1407053003880	Mg2+ binding site [ion binding]; other site
1407053003881	G-X-G motif; other site
1407053003882	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
1407053003883	multidrug efflux protein; Reviewed; Region: PRK01766
1407053003884	cation binding site [ion binding]; other site
1407053003885	Proline racemase [Amino acid transport and metabolism]; Region: COG3938
1407053003886	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
1407053003887	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
1407053003888	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
1407053003889	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
1407053003890	dimer interface [polypeptide binding]; other site
1407053003891	active site
1407053003892	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1407053003893	catalytic residues [active]
1407053003894	substrate binding site [chemical binding]; other site
1407053003895	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1407053003896	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1407053003897	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
1407053003898	FAD binding pocket [chemical binding]; other site
1407053003899	FAD binding motif [chemical binding]; other site
1407053003900	phosphate binding motif [ion binding]; other site
1407053003901	beta-alpha-beta structure motif; other site
1407053003902	NAD binding pocket [chemical binding]; other site
1407053003903	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
1407053003904	active site
1407053003905	oligomerization interface [polypeptide binding]; other site
1407053003906	metal binding site [ion binding]; metal-binding site
1407053003907	pantoate--beta-alanine ligase; Region: panC; TIGR00018
1407053003908	Pantoate-beta-alanine ligase; Region: PanC; cd00560
1407053003909	active site
1407053003910	ATP-binding site [chemical binding]; other site
1407053003911	pantoate-binding site; other site
1407053003912	HXXH motif; other site
1407053003913	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
1407053003914	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
1407053003915	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1407053003916	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1407053003917	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1407053003918	dimerization interface [polypeptide binding]; other site
1407053003919	Glycosyltransferase family 29 (sialyltransferase); Region: Glyco_transf_29; pfam00777
1407053003920	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
1407053003921	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1407053003922	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
1407053003923	putative active site [active]
1407053003924	putative metal binding site [ion binding]; other site
1407053003925	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1407053003926	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
1407053003927	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
1407053003928	Na binding site [ion binding]; other site
1407053003929	PAS fold; Region: PAS_7; pfam12860
1407053003930	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1407053003931	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1407053003932	dimer interface [polypeptide binding]; other site
1407053003933	phosphorylation site [posttranslational modification]
1407053003934	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1407053003935	ATP binding site [chemical binding]; other site
1407053003936	Mg2+ binding site [ion binding]; other site
1407053003937	G-X-G motif; other site
1407053003938	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1407053003939	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1407053003940	active site
1407053003941	phosphorylation site [posttranslational modification]
1407053003942	intermolecular recognition site; other site
1407053003943	dimerization interface [polypeptide binding]; other site
1407053003944	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1407053003945	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1407053003946	DNA binding residues [nucleotide binding]
1407053003947	dimerization interface [polypeptide binding]; other site
1407053003948	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
1407053003949	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1407053003950	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502
1407053003951	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
1407053003952	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
1407053003953	quinone interaction residues [chemical binding]; other site
1407053003954	active site
1407053003955	catalytic residues [active]
1407053003956	FMN binding site [chemical binding]; other site
1407053003957	substrate binding site [chemical binding]; other site
1407053003958	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
1407053003959	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
1407053003960	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
1407053003961	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1407053003962	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1407053003963	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
1407053003964	conserved cys residue [active]
1407053003965	2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559
1407053003966	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
1407053003967	trimer interface [polypeptide binding]; other site
1407053003968	active site
1407053003969	Deoxycytidine deaminase [Nucleotide transport and metabolism]; Region: Dcd; COG0717
1407053003970	trimer interface [polypeptide binding]; other site
1407053003971	active site
1407053003972	O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504
1407053003973	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1407053003974	homodimer interface [polypeptide binding]; other site
1407053003975	substrate-cofactor binding pocket; other site
1407053003976	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1407053003977	catalytic residue [active]
1407053003978	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
1407053003979	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
1407053003980	dimerization interface [polypeptide binding]; other site
1407053003981	domain crossover interface; other site
1407053003982	redox-dependent activation switch; other site
1407053003983	acetylornithine transaminase protein; Provisional; Region: argD; PRK01278
1407053003984	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1407053003985	inhibitor-cofactor binding pocket; inhibition site
1407053003986	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1407053003987	catalytic residue [active]
1407053003988	CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427
1407053003989	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1407053003990	DXD motif; other site
1407053003991	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1407053003992	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1407053003993	substrate binding pocket [chemical binding]; other site
1407053003994	membrane-bound complex binding site; other site
1407053003995	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1407053003996	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1407053003997	HlyD family secretion protein; Region: HlyD_3; pfam13437
1407053003998	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
1407053003999	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1407053004000	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
1407053004001	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
1407053004002	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1407053004003	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
1407053004004	acyl-activating enzyme (AAE) consensus motif; other site
1407053004005	putative AMP binding site [chemical binding]; other site
1407053004006	putative active site [active]
1407053004007	putative CoA binding site [chemical binding]; other site
1407053004008	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
1407053004009	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1407053004010	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1407053004011	motif II; other site
1407053004012	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
1407053004013	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
1407053004014	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
1407053004015	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1407053004016	active site
1407053004017	dimer interface [polypeptide binding]; other site
1407053004018	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1407053004019	dimer interface [polypeptide binding]; other site
1407053004020	active site
1407053004021	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
1407053004022	putative hydrophobic ligand binding site [chemical binding]; other site
1407053004023	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
1407053004024	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1407053004025	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1407053004026	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
1407053004027	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
1407053004028	homodimer interface [polypeptide binding]; other site
1407053004029	active site
1407053004030	FMN binding site [chemical binding]; other site
1407053004031	substrate binding site [chemical binding]; other site
1407053004032	4Fe-4S binding domain; Region: Fer4; cl02805
1407053004033	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
1407053004034	nudix motif; other site
1407053004035	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
1407053004036	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1407053004037	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
1407053004038	allantoate amidohydrolase; Reviewed; Region: PRK12893
1407053004039	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
1407053004040	active site
1407053004041	metal binding site [ion binding]; metal-binding site
1407053004042	dimer interface [polypeptide binding]; other site
1407053004043	phenylhydantoinase; Validated; Region: PRK08323
1407053004044	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
1407053004045	tetramer interface [polypeptide binding]; other site
1407053004046	active site
1407053004047	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1407053004048	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1407053004049	HlyD family secretion protein; Region: HlyD_3; pfam13437
1407053004050	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1407053004051	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1407053004052	ATP binding site [chemical binding]; other site
1407053004053	Mg2+ binding site [ion binding]; other site
1407053004054	G-X-G motif; other site
1407053004055	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1407053004056	Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371
1407053004057	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
1407053004058	dimer interface [polypeptide binding]; other site
1407053004059	catalytic residues [active]
1407053004060	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
1407053004061	gamma-beta subunit interface [polypeptide binding]; other site
1407053004062	alpha-beta subunit interface [polypeptide binding]; other site
1407053004063	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
1407053004064	alpha-gamma subunit interface [polypeptide binding]; other site
1407053004065	beta-gamma subunit interface [polypeptide binding]; other site
1407053004066	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
1407053004067	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1407053004068	non-specific DNA binding site [nucleotide binding]; other site
1407053004069	salt bridge; other site
1407053004070	sequence-specific DNA binding site [nucleotide binding]; other site
1407053004071	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1407053004072	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
1407053004073	catalytic nucleophile [active]
1407053004074	Prophage antirepressor [Transcription]; Region: COG3617
1407053004075	BRO family, N-terminal domain; Region: Bro-N; smart01040
1407053004076	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1407053004077	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1407053004078	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1407053004079	active site
1407053004080	DNA binding site [nucleotide binding]
1407053004081	Int/Topo IB signature motif; other site
1407053004082	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1407053004083	active site
1407053004084	hinge; other site
1407053004085	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
1407053004086	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1407053004087	NAD binding site [chemical binding]; other site
1407053004088	dimerization interface [polypeptide binding]; other site
1407053004089	product binding site; other site
1407053004090	substrate binding site [chemical binding]; other site
1407053004091	zinc binding site [ion binding]; other site
1407053004092	catalytic residues [active]
1407053004093	hypothetical protein; Provisional; Region: PRK02853
1407053004094	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1407053004095	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1407053004096	active site
1407053004097	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1407053004098	rRNA binding site [nucleotide binding]; other site
1407053004099	predicted 30S ribosome binding site; other site
1407053004100	Maf-like protein; Region: Maf; pfam02545
1407053004101	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1407053004102	active site
1407053004103	dimer interface [polypeptide binding]; other site
1407053004104	zinc-binding protein; Provisional; Region: PRK01343
1407053004105	TIR domain; Region: TIR_2; pfam13676
1407053004106	GcrA cell cycle regulator; Region: GcrA; cl11564
1407053004107	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1407053004108	non-specific DNA binding site [nucleotide binding]; other site
1407053004109	salt bridge; other site
1407053004110	sequence-specific DNA binding site [nucleotide binding]; other site
1407053004111	Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856
1407053004112	Toprim domain; Region: Toprim_3; pfam13362
1407053004113	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
1407053004114	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
1407053004115	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1407053004116	active site
1407053004117	Int/Topo IB signature motif; other site
1407053004118	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1407053004119	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1407053004120	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
1407053004121	human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368
1407053004122	NAD binding site [chemical binding]; other site
1407053004123	homotetramer interface [polypeptide binding]; other site
1407053004124	homodimer interface [polypeptide binding]; other site
1407053004125	active site
1407053004126	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1407053004127	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1407053004128	Uncharacterized conserved protein [Function unknown]; Region: COG3254
1407053004129	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1407053004130	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
1407053004131	substrate binding pocket [chemical binding]; other site
1407053004132	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1407053004133	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1407053004134	Walker A/P-loop; other site
1407053004135	ATP binding site [chemical binding]; other site
1407053004136	Q-loop/lid; other site
1407053004137	ABC transporter signature motif; other site
1407053004138	Walker B; other site
1407053004139	D-loop; other site
1407053004140	H-loop/switch region; other site
1407053004141	TOBE domain; Region: TOBE_2; pfam08402
1407053004142	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1407053004143	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053004144	dimer interface [polypeptide binding]; other site
1407053004145	conserved gate region; other site
1407053004146	putative PBP binding loops; other site
1407053004147	ABC-ATPase subunit interface; other site
1407053004148	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053004149	dimer interface [polypeptide binding]; other site
1407053004150	conserved gate region; other site
1407053004151	putative PBP binding loops; other site
1407053004152	ABC-ATPase subunit interface; other site
1407053004153	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1407053004154	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1407053004155	putative DNA binding site [nucleotide binding]; other site
1407053004156	putative Zn2+ binding site [ion binding]; other site
1407053004157	Bacterial transcriptional regulator; Region: IclR; pfam01614
1407053004158	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
1407053004159	Amidohydrolase; Region: Amidohydro_2; pfam04909
1407053004160	active site
1407053004161	Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583
1407053004162	Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311
1407053004163	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
1407053004164	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
1407053004165	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1407053004166	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
1407053004167	NAD(P) binding site [chemical binding]; other site
1407053004168	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
1407053004169	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053004170	dimer interface [polypeptide binding]; other site
1407053004171	conserved gate region; other site
1407053004172	ABC-ATPase subunit interface; other site
1407053004173	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
1407053004174	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
1407053004175	Walker A/P-loop; other site
1407053004176	ATP binding site [chemical binding]; other site
1407053004177	Q-loop/lid; other site
1407053004178	ABC transporter signature motif; other site
1407053004179	Walker B; other site
1407053004180	D-loop; other site
1407053004181	H-loop/switch region; other site
1407053004182	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1407053004183	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053004184	dimer interface [polypeptide binding]; other site
1407053004185	conserved gate region; other site
1407053004186	putative PBP binding loops; other site
1407053004187	ABC-ATPase subunit interface; other site
1407053004188	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
1407053004189	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
1407053004190	DNA binding residues [nucleotide binding]
1407053004191	dimer interface [polypeptide binding]; other site
1407053004192	copper binding site [ion binding]; other site
1407053004193	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1407053004194	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1407053004195	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1407053004196	metal-binding site [ion binding]
1407053004197	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1407053004198	metal-binding site [ion binding]
1407053004199	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1407053004200	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1407053004201	putative active site [active]
1407053004202	heme pocket [chemical binding]; other site
1407053004203	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1407053004204	putative active site [active]
1407053004205	heme pocket [chemical binding]; other site
1407053004206	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1407053004207	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1407053004208	metal binding site [ion binding]; metal-binding site
1407053004209	active site
1407053004210	I-site; other site
1407053004211	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1407053004212	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1407053004213	dimer interface [polypeptide binding]; other site
1407053004214	substrate binding site [chemical binding]; other site
1407053004215	ATP binding site [chemical binding]; other site
1407053004216	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
1407053004217	thiS-thiF/thiG interaction site; other site
1407053004218	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
1407053004219	ThiS interaction site; other site
1407053004220	putative active site [active]
1407053004221	tetramer interface [polypeptide binding]; other site
1407053004222	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1407053004223	active site
1407053004224	thiamine phosphate binding site [chemical binding]; other site
1407053004225	pyrophosphate binding site [ion binding]; other site
1407053004226	NMT1/THI5 like; Region: NMT1; pfam09084
1407053004227	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1407053004228	Putative transcription activator [Transcription]; Region: TenA; COG0819
1407053004229	Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097
1407053004230	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1407053004231	NAD(P) binding site [chemical binding]; other site
1407053004232	catalytic residues [active]
1407053004233	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1407053004234	ABC transporter signature motif; other site
1407053004235	Walker B; other site
1407053004236	D-loop; other site
1407053004237	H-loop/switch region; other site
1407053004238	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1407053004239	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1407053004240	DNA binding site [nucleotide binding]
1407053004241	domain linker motif; other site
1407053004242	Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545
1407053004243	putative dimerization interface [polypeptide binding]; other site
1407053004244	putative ligand binding site [chemical binding]; other site
1407053004245	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1407053004246	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
1407053004247	NAD binding site [chemical binding]; other site
1407053004248	substrate binding site [chemical binding]; other site
1407053004249	catalytic Zn binding site [ion binding]; other site
1407053004250	tetramer interface [polypeptide binding]; other site
1407053004251	structural Zn binding site [ion binding]; other site
1407053004252	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
1407053004253	GAF domain; Region: GAF; pfam01590
1407053004254	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1407053004255	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
1407053004256	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1407053004257	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
1407053004258	active site
1407053004259	dimerization interface [polypeptide binding]; other site
1407053004260	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1407053004261	DNA binding residues [nucleotide binding]
1407053004262	dimerization interface [polypeptide binding]; other site
1407053004263	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1407053004264	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1407053004265	ligand binding site [chemical binding]; other site
1407053004266	flexible hinge region; other site
1407053004267	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1407053004268	putative switch regulator; other site
1407053004269	non-specific DNA interactions [nucleotide binding]; other site
1407053004270	DNA binding site [nucleotide binding]
1407053004271	sequence specific DNA binding site [nucleotide binding]; other site
1407053004272	putative cAMP binding site [chemical binding]; other site
1407053004273	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
1407053004274	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1407053004275	active site
1407053004276	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
1407053004277	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
1407053004278	CysD dimerization site [polypeptide binding]; other site
1407053004279	G1 box; other site
1407053004280	putative GEF interaction site [polypeptide binding]; other site
1407053004281	GTP/Mg2+ binding site [chemical binding]; other site
1407053004282	Switch I region; other site
1407053004283	G2 box; other site
1407053004284	G3 box; other site
1407053004285	Switch II region; other site
1407053004286	G4 box; other site
1407053004287	G5 box; other site
1407053004288	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
1407053004289	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
1407053004290	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1407053004291	active site
1407053004292	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
1407053004293	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1407053004294	Active Sites [active]
1407053004295	aminotransferase; Provisional; Region: PRK06105
1407053004296	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1407053004297	inhibitor-cofactor binding pocket; inhibition site
1407053004298	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1407053004299	catalytic residue [active]
1407053004300	Autoinducer binding domain; Region: Autoind_bind; pfam03472
1407053004301	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1407053004302	DNA binding residues [nucleotide binding]
1407053004303	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
1407053004304	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
1407053004305	BA14K-like protein; Region: BA14K; pfam07886
1407053004306	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1407053004307	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1407053004308	active site
1407053004309	DNA binding site [nucleotide binding]
1407053004310	Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876
1407053004311	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1407053004312	Active Sites [active]
1407053004313	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
1407053004314	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1407053004315	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1407053004316	Protein of unknown function (DUF2849); Region: DUF2849; pfam11011
1407053004317	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
1407053004318	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
1407053004319	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
1407053004320	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1407053004321	active site
1407053004322	SAM binding site [chemical binding]; other site
1407053004323	homodimer interface [polypeptide binding]; other site
1407053004324	hypothetical protein; Reviewed; Region: PRK12497
1407053004325	Predicted methyltransferases [General function prediction only]; Region: COG0313
1407053004326	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1407053004327	putative SAM binding site [chemical binding]; other site
1407053004328	putative homodimer interface [polypeptide binding]; other site
1407053004329	coproporphyrinogen III oxidase; Provisional; Region: PRK09057
1407053004330	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1407053004331	FeS/SAM binding site; other site
1407053004332	HemN C-terminal domain; Region: HemN_C; pfam06969
1407053004333	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1407053004334	active site
1407053004335	dimerization interface [polypeptide binding]; other site
1407053004336	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1407053004337	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354
1407053004338	putative metal binding site [ion binding]; other site
1407053004339	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
1407053004340	heat shock protein GrpE; Provisional; Region: PRK14141
1407053004341	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1407053004342	dimer interface [polypeptide binding]; other site
1407053004343	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1407053004344	Predicted membrane protein [Function unknown]; Region: COG2860
1407053004345	UPF0126 domain; Region: UPF0126; pfam03458
1407053004346	UPF0126 domain; Region: UPF0126; pfam03458
1407053004347	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
1407053004348	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1407053004349	substrate binding site [chemical binding]; other site
1407053004350	ATP binding site [chemical binding]; other site
1407053004351	Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126
1407053004352	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
1407053004353	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1407053004354	minor groove reading motif; other site
1407053004355	helix-hairpin-helix signature motif; other site
1407053004356	substrate binding pocket [chemical binding]; other site
1407053004357	active site
1407053004358	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
1407053004359	Integral membrane protein [Function unknown]; Region: COG5488
1407053004360	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1407053004361	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
1407053004362	putative dimer interface [polypeptide binding]; other site
1407053004363	Uncharacterized small protein [Function unknown]; Region: COG5568
1407053004364	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1407053004365	active site
1407053004366	phosphorylation site [posttranslational modification]
1407053004367	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1407053004368	30S subunit binding site; other site
1407053004369	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
1407053004370	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
1407053004371	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
1407053004372	Walker A/P-loop; other site
1407053004373	ATP binding site [chemical binding]; other site
1407053004374	Q-loop/lid; other site
1407053004375	ABC transporter signature motif; other site
1407053004376	Walker B; other site
1407053004377	D-loop; other site
1407053004378	H-loop/switch region; other site
1407053004379	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
1407053004380	OstA-like protein; Region: OstA; pfam03968
1407053004381	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375
1407053004382	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
1407053004383	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
1407053004384	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
1407053004385	tandem repeat interface [polypeptide binding]; other site
1407053004386	oligomer interface [polypeptide binding]; other site
1407053004387	active site residues [active]
1407053004388	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1407053004389	IHF dimer interface [polypeptide binding]; other site
1407053004390	IHF - DNA interface [nucleotide binding]; other site
1407053004391	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
1407053004392	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1407053004393	S-adenosylmethionine binding site [chemical binding]; other site
1407053004394	Putative hemolysin [General function prediction only]; Region: COG3176
1407053004395	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
1407053004396	MutS domain I; Region: MutS_I; pfam01624
1407053004397	MutS domain II; Region: MutS_II; pfam05188
1407053004398	MutS domain III; Region: MutS_III; pfam05192
1407053004399	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
1407053004400	Walker A/P-loop; other site
1407053004401	ATP binding site [chemical binding]; other site
1407053004402	Q-loop/lid; other site
1407053004403	ABC transporter signature motif; other site
1407053004404	Walker B; other site
1407053004405	D-loop; other site
1407053004406	H-loop/switch region; other site
1407053004407	PII uridylyl-transferase; Provisional; Region: PRK05092
1407053004408	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1407053004409	metal binding triad; other site
1407053004410	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1407053004411	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1407053004412	Zn2+ binding site [ion binding]; other site
1407053004413	Mg2+ binding site [ion binding]; other site
1407053004414	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
1407053004415	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
1407053004416	integral membrane protein MviN; Region: mviN; TIGR01695
1407053004417	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
1407053004418	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1407053004419	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1407053004420	active site
1407053004421	HIGH motif; other site
1407053004422	dimer interface [polypeptide binding]; other site
1407053004423	KMSKS motif; other site
1407053004424	Universal stress protein family; Region: Usp; pfam00582
1407053004425	Ligand Binding Site [chemical binding]; other site
1407053004426	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
1407053004427	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
1407053004428	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1407053004429	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1407053004430	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
1407053004431	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1407053004432	active site
1407053004433	phosphorylation site [posttranslational modification]
1407053004434	intermolecular recognition site; other site
1407053004435	dimerization interface [polypeptide binding]; other site
1407053004436	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1407053004437	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
1407053004438	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1407053004439	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1407053004440	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1407053004441	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1407053004442	ATP binding site [chemical binding]; other site
1407053004443	Mg2+ binding site [ion binding]; other site
1407053004444	G-X-G motif; other site
1407053004445	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
1407053004446	putative metal binding site [ion binding]; other site
1407053004447	putative homodimer interface [polypeptide binding]; other site
1407053004448	putative homotetramer interface [polypeptide binding]; other site
1407053004449	putative homodimer-homodimer interface [polypeptide binding]; other site
1407053004450	putative allosteric switch controlling residues; other site
1407053004451	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
1407053004452	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
1407053004453	substrate binding site [chemical binding]; other site
1407053004454	catalytic Zn binding site [ion binding]; other site
1407053004455	NAD binding site [chemical binding]; other site
1407053004456	structural Zn binding site [ion binding]; other site
1407053004457	dimer interface [polypeptide binding]; other site
1407053004458	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1407053004459	Coenzyme A binding pocket [chemical binding]; other site
1407053004460	Predicted membrane protein [Function unknown]; Region: COG4291
1407053004461	S-formylglutathione hydrolase; Region: PLN02442
1407053004462	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
1407053004463	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1407053004464	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
1407053004465	Mg2+ binding site [ion binding]; other site
1407053004466	G-X-G motif; other site
1407053004467	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1407053004468	anchoring element; other site
1407053004469	dimer interface [polypeptide binding]; other site
1407053004470	ATP binding site [chemical binding]; other site
1407053004471	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1407053004472	active site
1407053004473	putative metal-binding site [ion binding]; other site
1407053004474	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1407053004475	5'-3' exonuclease; Region: 53EXOc; smart00475
1407053004476	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1407053004477	active site
1407053004478	metal binding site 1 [ion binding]; metal-binding site
1407053004479	putative 5' ssDNA interaction site; other site
1407053004480	metal binding site 3; metal-binding site
1407053004481	metal binding site 2 [ion binding]; metal-binding site
1407053004482	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1407053004483	putative DNA binding site [nucleotide binding]; other site
1407053004484	putative metal binding site [ion binding]; other site
1407053004485	hypothetical protein; Validated; Region: PRK09104
1407053004486	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
1407053004487	metal binding site [ion binding]; metal-binding site
1407053004488	putative dimer interface [polypeptide binding]; other site
1407053004489	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
1407053004490	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
1407053004491	catalytic site [active]
1407053004492	putative active site [active]
1407053004493	putative substrate binding site [chemical binding]; other site
1407053004494	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
1407053004495	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
1407053004496	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
1407053004497	Transglycosylase; Region: Transgly; pfam00912
1407053004498	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1407053004499	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1407053004500	classical (c) SDRs; Region: SDR_c; cd05233
1407053004501	NAD(P) binding site [chemical binding]; other site
1407053004502	active site
1407053004503	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1407053004504	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
1407053004505	putative substrate binding site [chemical binding]; other site
1407053004506	putative ATP binding site [chemical binding]; other site
1407053004507	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1407053004508	S-adenosylmethionine binding site [chemical binding]; other site
1407053004509	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
1407053004510	Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488
1407053004511	nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321
1407053004512	active site
1407053004513	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1407053004514	Protein of unknown function (DUF3131); Region: DUF3131; pfam11329
1407053004515	Putative glucoamylase; Region: Glycoamylase; pfam10091
1407053004516	Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753
1407053004517	First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756
1407053004518	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
1407053004519	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
1407053004520	Walker A/P-loop; other site
1407053004521	ATP binding site [chemical binding]; other site
1407053004522	Q-loop/lid; other site
1407053004523	ABC transporter signature motif; other site
1407053004524	Walker B; other site
1407053004525	D-loop; other site
1407053004526	H-loop/switch region; other site
1407053004527	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053004528	dimer interface [polypeptide binding]; other site
1407053004529	conserved gate region; other site
1407053004530	putative PBP binding loops; other site
1407053004531	ABC-ATPase subunit interface; other site
1407053004532	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1407053004533	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053004534	dimer interface [polypeptide binding]; other site
1407053004535	conserved gate region; other site
1407053004536	putative PBP binding loops; other site
1407053004537	ABC-ATPase subunit interface; other site
1407053004538	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
1407053004539	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1407053004540	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604
1407053004541	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1407053004542	AsnC family; Region: AsnC_trans_reg; pfam01037
1407053004543	response regulator; Provisional; Region: PRK13435
1407053004544	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
1407053004545	heme exporter protein CcmD; Region: cytochro_ccmD; TIGR03141
1407053004546	heme exporter protein CcmC; Region: ccmC; TIGR01191
1407053004547	ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmB; COG2386
1407053004548	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539
1407053004549	Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231
1407053004550	Walker A/P-loop; other site
1407053004551	ATP binding site [chemical binding]; other site
1407053004552	Q-loop/lid; other site
1407053004553	ABC transporter signature motif; other site
1407053004554	Walker B; other site
1407053004555	D-loop; other site
1407053004556	H-loop/switch region; other site
1407053004557	aconitate hydratase; Validated; Region: PRK09277
1407053004558	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
1407053004559	substrate binding site [chemical binding]; other site
1407053004560	ligand binding site [chemical binding]; other site
1407053004561	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
1407053004562	substrate binding site [chemical binding]; other site
1407053004563	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1407053004564	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1407053004565	Coenzyme A binding pocket [chemical binding]; other site
1407053004566	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
1407053004567	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
1407053004568	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
1407053004569	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
1407053004570	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1407053004571	Walker A/P-loop; other site
1407053004572	ATP binding site [chemical binding]; other site
1407053004573	Q-loop/lid; other site
1407053004574	ABC transporter signature motif; other site
1407053004575	Walker B; other site
1407053004576	D-loop; other site
1407053004577	H-loop/switch region; other site
1407053004578	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
1407053004579	active site
1407053004580	oxyanion hole [active]
1407053004581	switch loop; other site
1407053004582	catalytic triad [active]
1407053004583	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
1407053004584	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
1407053004585	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
1407053004586	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1407053004587	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1407053004588	active site
1407053004589	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
1407053004590	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1407053004591	FeS/SAM binding site; other site
1407053004592	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1407053004593	Invasion associated locus B (IalB) protein; Region: IalB; cl02207
1407053004594	Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295
1407053004595	Haemagglutinin; Region: HIM; pfam05662
1407053004596	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
1407053004597	trimer interface [polypeptide binding]; other site
1407053004598	Haemagglutinin; Region: HIM; pfam05662
1407053004599	YadA-like C-terminal region; Region: YadA; pfam03895
1407053004600	DNA Polymerase Y-family; Region: PolY_like; cd03468
1407053004601	active site
1407053004602	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
1407053004603	DNA binding site [nucleotide binding]
1407053004604	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
1407053004605	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1407053004606	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1407053004607	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1407053004608	catalytic residue [active]
1407053004609	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1407053004610	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1407053004611	nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270
1407053004612	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1407053004613	active site
1407053004614	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
1407053004615	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1407053004616	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1407053004617	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1407053004618	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
1407053004619	putative effector binding pocket; other site
1407053004620	putative dimerization interface [polypeptide binding]; other site
1407053004621	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
1407053004622	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
1407053004623	active site
1407053004624	substrate binding site [chemical binding]; other site
1407053004625	metal binding site [ion binding]; metal-binding site
1407053004626	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1407053004627	Walker A motif; other site
1407053004628	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1407053004629	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1407053004630	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1407053004631	active site
1407053004632	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
1407053004633	Copper(I)-binding protein [Inorganic ion transport and    metabolism]; Region: COG2847
1407053004634	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1407053004635	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1407053004636	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
1407053004637	Surface antigen; Region: Bac_surface_Ag; pfam01103
1407053004638	Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125
1407053004639	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
1407053004640	Subunit III/IV interface [polypeptide binding]; other site
1407053004641	Subunit I/III interface [polypeptide binding]; other site
1407053004642	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1407053004643	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1407053004644	D-pathway; other site
1407053004645	Putative ubiquinol binding site [chemical binding]; other site
1407053004646	Low-spin heme (heme b) binding site [chemical binding]; other site
1407053004647	Putative water exit pathway; other site
1407053004648	Binuclear center (heme o3/CuB) [ion binding]; other site
1407053004649	K-pathway; other site
1407053004650	Putative proton exit pathway; other site
1407053004651	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1407053004652	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
1407053004653	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1407053004654	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
1407053004655	putative MPT binding site; other site
1407053004656	Cytochrome c2 [Energy production and conversion]; Region: COG3474
1407053004657	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
1407053004658	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
1407053004659	Ligand binding site; other site
1407053004660	oligomer interface; other site
1407053004661	prephenate dehydratase; Provisional; Region: PRK11899
1407053004662	Prephenate dehydratase; Region: PDT; pfam00800
1407053004663	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1407053004664	putative L-Phe binding site [chemical binding]; other site
1407053004665	HIT domain; Region: HIT; pfam01230
1407053004666	DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111
1407053004667	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1407053004668	Walker A motif; other site
1407053004669	ATP binding site [chemical binding]; other site
1407053004670	Walker B motif; other site
1407053004671	arginine finger; other site
1407053004672	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
1407053004673	DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362
1407053004674	hypothetical protein; Validated; Region: PRK00153
1407053004675	recombination protein RecR; Reviewed; Region: recR; PRK00076
1407053004676	RecR protein; Region: RecR; pfam02132
1407053004677	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1407053004678	putative active site [active]
1407053004679	putative metal-binding site [ion binding]; other site
1407053004680	tetramer interface [polypeptide binding]; other site
1407053004681	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
1407053004682	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1407053004683	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
1407053004684	putative dimerization interface [polypeptide binding]; other site
1407053004685	Predicted membrane protein [Function unknown]; Region: COG2855
1407053004686	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
1407053004687	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1407053004688	RNA binding site [nucleotide binding]; other site
1407053004689	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1407053004690	RNA binding site [nucleotide binding]; other site
1407053004691	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
1407053004692	RNA binding site [nucleotide binding]; other site
1407053004693	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1407053004694	RNA binding site [nucleotide binding]; other site
1407053004695	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1407053004696	RNA binding site [nucleotide binding]; other site
1407053004697	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
1407053004698	RNA binding site [nucleotide binding]; other site
1407053004699	cytidylate kinase; Provisional; Region: cmk; PRK00023
1407053004700	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1407053004701	CMP-binding site; other site
1407053004702	The sites determining sugar specificity; other site
1407053004703	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1407053004704	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1407053004705	hinge; other site
1407053004706	active site
1407053004707	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4530
1407053004708	Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538
1407053004709	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1407053004710	CHRD domain; Region: CHRD; pfam07452
1407053004711	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
1407053004712	Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943
1407053004713	acyl-activating enzyme (AAE) consensus motif; other site
1407053004714	putative AMP binding site [chemical binding]; other site
1407053004715	putative active site [active]
1407053004716	putative CoA binding site [chemical binding]; other site
1407053004717	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
1407053004718	isovaleryl-CoA dehydrogenase; Region: PLN02519
1407053004719	substrate binding site [chemical binding]; other site
1407053004720	FAD binding site [chemical binding]; other site
1407053004721	catalytic base [active]
1407053004722	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1407053004723	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
1407053004724	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1407053004725	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1407053004726	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1407053004727	carboxyltransferase (CT) interaction site; other site
1407053004728	biotinylation site [posttranslational modification]; other site
1407053004729	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
1407053004730	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
1407053004731	active site
1407053004732	catalytic residues [active]
1407053004733	metal binding site [ion binding]; metal-binding site
1407053004734	enoyl-CoA hydratase; Provisional; Region: PRK07468
1407053004735	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1407053004736	substrate binding site [chemical binding]; other site
1407053004737	oxyanion hole (OAH) forming residues; other site
1407053004738	trimer interface [polypeptide binding]; other site
1407053004739	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1407053004740	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1407053004741	dimerization interface [polypeptide binding]; other site
1407053004742	ligand binding site [chemical binding]; other site
1407053004743	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
1407053004744	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053004745	dimer interface [polypeptide binding]; other site
1407053004746	conserved gate region; other site
1407053004747	putative PBP binding loops; other site
1407053004748	ABC-ATPase subunit interface; other site
1407053004749	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
1407053004750	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053004751	dimer interface [polypeptide binding]; other site
1407053004752	conserved gate region; other site
1407053004753	putative PBP binding loops; other site
1407053004754	ABC-ATPase subunit interface; other site
1407053004755	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
1407053004756	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1407053004757	Walker A/P-loop; other site
1407053004758	ATP binding site [chemical binding]; other site
1407053004759	Q-loop/lid; other site
1407053004760	ABC transporter signature motif; other site
1407053004761	Walker B; other site
1407053004762	D-loop; other site
1407053004763	H-loop/switch region; other site
1407053004764	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1407053004765	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1407053004766	Walker A/P-loop; other site
1407053004767	ATP binding site [chemical binding]; other site
1407053004768	Q-loop/lid; other site
1407053004769	ABC transporter signature motif; other site
1407053004770	Walker B; other site
1407053004771	D-loop; other site
1407053004772	H-loop/switch region; other site
1407053004773	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1407053004774	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1407053004775	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
1407053004776	putative ligand binding site [chemical binding]; other site
1407053004777	NAD binding site [chemical binding]; other site
1407053004778	dimerization interface [polypeptide binding]; other site
1407053004779	catalytic site [active]
1407053004780	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
1407053004781	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1407053004782	ATP binding site [chemical binding]; other site
1407053004783	substrate interface [chemical binding]; other site
1407053004784	recombination protein F; Reviewed; Region: recF; PRK00064
1407053004785	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
1407053004786	Walker A/P-loop; other site
1407053004787	ATP binding site [chemical binding]; other site
1407053004788	Q-loop/lid; other site
1407053004789	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1407053004790	ABC transporter signature motif; other site
1407053004791	Walker B; other site
1407053004792	D-loop; other site
1407053004793	H-loop/switch region; other site
1407053004794	DNA polymerase III subunit beta; Validated; Region: PRK05643
1407053004795	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1407053004796	putative DNA binding surface [nucleotide binding]; other site
1407053004797	dimer interface [polypeptide binding]; other site
1407053004798	beta-clamp/clamp loader binding surface; other site
1407053004799	beta-clamp/translesion DNA polymerase binding surface; other site
1407053004800	DnaA N-terminal domain; Region: DnaA_N; pfam11638
1407053004801	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
1407053004802	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1407053004803	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1407053004804	DnaA box-binding interface [nucleotide binding]; other site
1407053004805	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1407053004806	enoyl-CoA hydratase; Provisional; Region: PRK05862
1407053004807	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1407053004808	substrate binding site [chemical binding]; other site
1407053004809	oxyanion hole (OAH) forming residues; other site
1407053004810	trimer interface [polypeptide binding]; other site
1407053004811	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
1407053004812	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1407053004813	DNA binding site [nucleotide binding]
1407053004814	catalytic residue [active]
1407053004815	H2TH interface [polypeptide binding]; other site
1407053004816	putative catalytic residues [active]
1407053004817	turnover-facilitating residue; other site
1407053004818	intercalation triad [nucleotide binding]; other site
1407053004819	8OG recognition residue [nucleotide binding]; other site
1407053004820	putative reading head residues; other site
1407053004821	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1407053004822	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1407053004823	Flp/Fap pilin component; Region: Flp_Fap; cl01585
1407053004824	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1407053004825	MarR family; Region: MarR; pfam01047
1407053004826	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1407053004827	NlpC/P60 family; Region: NLPC_P60; cl17555
1407053004828	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1407053004829	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1407053004830	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
1407053004831	dimerization interface [polypeptide binding]; other site
1407053004832	ligand binding site [chemical binding]; other site
1407053004833	NADP binding site [chemical binding]; other site
1407053004834	catalytic site [active]
1407053004835	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807
1407053004836	Bacterial SH3 domain; Region: SH3_4; pfam06347
1407053004837	Bacterial SH3 domain; Region: SH3_4; pfam06347
1407053004838	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1407053004839	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1407053004840	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1407053004841	metal binding site 2 [ion binding]; metal-binding site
1407053004842	putative DNA binding helix; other site
1407053004843	metal binding site 1 [ion binding]; metal-binding site
1407053004844	dimer interface [polypeptide binding]; other site
1407053004845	structural Zn2+ binding site [ion binding]; other site
1407053004846	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
1407053004847	active site 1 [active]
1407053004848	dimer interface [polypeptide binding]; other site
1407053004849	active site 2 [active]
1407053004850	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
1407053004851	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1407053004852	dimer interface [polypeptide binding]; other site
1407053004853	active site
1407053004854	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505
1407053004855	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
1407053004856	NAD binding site [chemical binding]; other site
1407053004857	homotetramer interface [polypeptide binding]; other site
1407053004858	homodimer interface [polypeptide binding]; other site
1407053004859	substrate binding site [chemical binding]; other site
1407053004860	active site
1407053004861	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
1407053004862	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1407053004863	S-adenosylmethionine binding site [chemical binding]; other site
1407053004864	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
1407053004865	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
1407053004866	RNase E interface [polypeptide binding]; other site
1407053004867	trimer interface [polypeptide binding]; other site
1407053004868	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
1407053004869	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1407053004870	RNase E interface [polypeptide binding]; other site
1407053004871	trimer interface [polypeptide binding]; other site
1407053004872	active site
1407053004873	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1407053004874	putative nucleic acid binding region [nucleotide binding]; other site
1407053004875	G-X-X-G motif; other site
1407053004876	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1407053004877	RNA binding site [nucleotide binding]; other site
1407053004878	domain interface; other site
1407053004879	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1407053004880	16S/18S rRNA binding site [nucleotide binding]; other site
1407053004881	S13e-L30e interaction site [polypeptide binding]; other site
1407053004882	25S rRNA binding site [nucleotide binding]; other site
1407053004883	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389
1407053004884	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1407053004885	RNA binding site [nucleotide binding]; other site
1407053004886	active site
1407053004887	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
1407053004888	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1407053004889	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1407053004890	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
1407053004891	NusA N-terminal domain; Region: NusA_N; pfam08529
1407053004892	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1407053004893	RNA binding site [nucleotide binding]; other site
1407053004894	homodimer interface [polypeptide binding]; other site
1407053004895	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1407053004896	G-X-X-G motif; other site
1407053004897	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1407053004898	G-X-X-G motif; other site
1407053004899	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
1407053004900	ribosome maturation protein RimP; Reviewed; Region: PRK00092
1407053004901	Sm and related proteins; Region: Sm_like; cl00259
1407053004902	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1407053004903	putative oligomer interface [polypeptide binding]; other site
1407053004904	putative RNA binding site [nucleotide binding]; other site
1407053004905	Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only]; Region: COG0220
1407053004906	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1407053004907	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1407053004908	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1407053004909	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1407053004910	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1407053004911	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1407053004912	non-specific DNA binding site [nucleotide binding]; other site
1407053004913	salt bridge; other site
1407053004914	sequence-specific DNA binding site [nucleotide binding]; other site
1407053004915	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
1407053004916	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
1407053004917	putative active site [active]
1407053004918	catalytic triad [active]
1407053004919	putative dimer interface [polypeptide binding]; other site
1407053004920	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319
1407053004921	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1407053004922	PhoH-like protein; Region: PhoH; pfam02562
1407053004923	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
1407053004924	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1407053004925	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1407053004926	FeS/SAM binding site; other site
1407053004927	TRAM domain; Region: TRAM; cl01282
1407053004928	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1407053004929	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1407053004930	putative acyl-acceptor binding pocket; other site
1407053004931	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1407053004932	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1407053004933	Coenzyme A binding pocket [chemical binding]; other site
1407053004934	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
1407053004935	Glycoprotease family; Region: Peptidase_M22; pfam00814
1407053004936	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1407053004937	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1407053004938	dimerization interface [polypeptide binding]; other site
1407053004939	DPS ferroxidase diiron center [ion binding]; other site
1407053004940	ion pore; other site
1407053004941	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
1407053004942	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
1407053004943	Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773
1407053004944	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
1407053004945	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1407053004946	active site
1407053004947	phosphorylation site [posttranslational modification]
1407053004948	intermolecular recognition site; other site
1407053004949	dimerization interface [polypeptide binding]; other site
1407053004950	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1407053004951	DNA binding site [nucleotide binding]
1407053004952	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
1407053004953	PhoU domain; Region: PhoU; pfam01895
1407053004954	PhoU domain; Region: PhoU; pfam01895
1407053004955	phosphate transporter ATP-binding protein; Provisional; Region: PRK14235
1407053004956	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1407053004957	Walker A/P-loop; other site
1407053004958	ATP binding site [chemical binding]; other site
1407053004959	Q-loop/lid; other site
1407053004960	ABC transporter signature motif; other site
1407053004961	Walker B; other site
1407053004962	D-loop; other site
1407053004963	H-loop/switch region; other site
1407053004964	Domain of unknown function (DUF3333); Region: DUF3333; pfam11812
1407053004965	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
1407053004966	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053004967	dimer interface [polypeptide binding]; other site
1407053004968	conserved gate region; other site
1407053004969	putative PBP binding loops; other site
1407053004970	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1407053004971	ABC-ATPase subunit interface; other site
1407053004972	Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501
1407053004973	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053004974	dimer interface [polypeptide binding]; other site
1407053004975	conserved gate region; other site
1407053004976	ABC-ATPase subunit interface; other site
1407053004977	PBP superfamily domain; Region: PBP_like_2; pfam12849
1407053004978	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
1407053004979	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
1407053004980	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
1407053004981	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035
1407053004982	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
1407053004983	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1407053004984	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1407053004985	Walker A motif; other site
1407053004986	ATP binding site [chemical binding]; other site
1407053004987	Walker B motif; other site
1407053004988	arginine finger; other site
1407053004989	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
1407053004990	glutathione synthetase; Provisional; Region: PRK05246
1407053004991	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
1407053004992	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
1407053004993	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
1407053004994	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1407053004995	active site
1407053004996	dimer interface [polypeptide binding]; other site
1407053004997	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1407053004998	S-adenosylmethionine binding site [chemical binding]; other site
1407053004999	chaperone protein DnaJ; Provisional; Region: PRK10767
1407053005000	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1407053005001	HSP70 interaction site [polypeptide binding]; other site
1407053005002	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
1407053005003	substrate binding site [polypeptide binding]; other site
1407053005004	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1407053005005	Zn binding sites [ion binding]; other site
1407053005006	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1407053005007	dimer interface [polypeptide binding]; other site
1407053005008	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1407053005009	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
1407053005010	nucleotide binding site [chemical binding]; other site
1407053005011	NEF interaction site [polypeptide binding]; other site
1407053005012	SBD interface [polypeptide binding]; other site
1407053005013	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1407053005014	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1407053005015	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1407053005016	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1407053005017	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1407053005018	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1407053005019	dimer interface [polypeptide binding]; other site
1407053005020	motif 1; other site
1407053005021	active site
1407053005022	motif 2; other site
1407053005023	motif 3; other site
1407053005024	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1407053005025	23S rRNA binding site [nucleotide binding]; other site
1407053005026	L21 binding site [polypeptide binding]; other site
1407053005027	L13 binding site [polypeptide binding]; other site
1407053005028	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1407053005029	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
1407053005030	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
1407053005031	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1407053005032	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1407053005033	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1407053005034	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1407053005035	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1407053005036	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1407053005037	putative active site [active]
1407053005038	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
1407053005039	active site
1407053005040	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
1407053005041	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1407053005042	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
1407053005043	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1407053005044	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1407053005045	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1407053005046	catalytic residues [active]
1407053005047	double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786
1407053005048	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
1407053005049	PAS fold; Region: PAS_7; pfam12860
1407053005050	PAS fold; Region: PAS_7; pfam12860
1407053005051	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1407053005052	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1407053005053	dimer interface [polypeptide binding]; other site
1407053005054	phosphorylation site [posttranslational modification]
1407053005055	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1407053005056	ATP binding site [chemical binding]; other site
1407053005057	Mg2+ binding site [ion binding]; other site
1407053005058	G-X-G motif; other site
1407053005059	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
1407053005060	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
1407053005061	homotetramer interface [polypeptide binding]; other site
1407053005062	ligand binding site [chemical binding]; other site
1407053005063	catalytic site [active]
1407053005064	NAD binding site [chemical binding]; other site
1407053005065	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1407053005066	dimerization domain swap beta strand [polypeptide binding]; other site
1407053005067	regulatory protein interface [polypeptide binding]; other site
1407053005068	active site
1407053005069	regulatory phosphorylation site [posttranslational modification]; other site
1407053005070	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1407053005071	active pocket/dimerization site; other site
1407053005072	active site
1407053005073	phosphorylation site [posttranslational modification]
1407053005074	Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755
1407053005075	Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756
1407053005076	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1407053005077	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1407053005078	dimerization interface [polypeptide binding]; other site
1407053005079	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1407053005080	dimer interface [polypeptide binding]; other site
1407053005081	phosphorylation site [posttranslational modification]
1407053005082	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1407053005083	ATP binding site [chemical binding]; other site
1407053005084	Mg2+ binding site [ion binding]; other site
1407053005085	G-X-G motif; other site
1407053005086	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1407053005087	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1407053005088	active site
1407053005089	phosphorylation site [posttranslational modification]
1407053005090	intermolecular recognition site; other site
1407053005091	dimerization interface [polypeptide binding]; other site
1407053005092	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1407053005093	DNA binding site [nucleotide binding]
1407053005094	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
1407053005095	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
1407053005096	active site
1407053005097	substrate-binding site [chemical binding]; other site
1407053005098	metal-binding site [ion binding]
1407053005099	ATP binding site [chemical binding]; other site
1407053005100	hypothetical protein; Provisional; Region: PRK09256
1407053005101	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
1407053005102	pantothenate kinase; Provisional; Region: PRK05439
1407053005103	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
1407053005104	ATP-binding site [chemical binding]; other site
1407053005105	CoA-binding site [chemical binding]; other site
1407053005106	Mg2+-binding site [ion binding]; other site
1407053005107	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
1407053005108	metal binding site [ion binding]; metal-binding site
1407053005109	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1407053005110	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1407053005111	substrate binding site [chemical binding]; other site
1407053005112	glutamase interaction surface [polypeptide binding]; other site
1407053005113	hisA/hisF family protein; Region: hisAF_rel; TIGR00734
1407053005114	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
1407053005115	catalytic residues [active]
1407053005116	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
1407053005117	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1407053005118	putative active site [active]
1407053005119	oxyanion strand; other site
1407053005120	catalytic triad [active]
1407053005121	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cl00341
1407053005122	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
1407053005123	active site
1407053005124	HslU subunit interaction site [polypeptide binding]; other site
1407053005125	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
1407053005126	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1407053005127	Walker A motif; other site
1407053005128	ATP binding site [chemical binding]; other site
1407053005129	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
1407053005130	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1407053005131	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1407053005132	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1407053005133	sequence-specific DNA binding site [nucleotide binding]; other site
1407053005134	salt bridge; other site
1407053005135	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
1407053005136	Smr domain; Region: Smr; pfam01713
1407053005137	MltA specific insert domain; Region: MltA; pfam03562
1407053005138	3D domain; Region: 3D; pfam06725
1407053005139	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395
1407053005140	Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030
1407053005141	preprotein translocase subunit SecB; Validated; Region: PRK05751
1407053005142	SecA binding site; other site
1407053005143	Preprotein binding site; other site
1407053005144	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
1407053005145	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
1407053005146	active site
1407053005147	catalytic site [active]
1407053005148	substrate binding site [chemical binding]; other site
1407053005149	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
1407053005150	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1407053005151	CoA-binding site [chemical binding]; other site
1407053005152	ATP-binding [chemical binding]; other site
1407053005153	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
1407053005154	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1407053005155	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1407053005156	shikimate binding site; other site
1407053005157	NAD(P) binding site [chemical binding]; other site
1407053005158	Maf-like protein; Reviewed; Region: PRK00078
1407053005159	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1407053005160	active site
1407053005161	dimer interface [polypeptide binding]; other site
1407053005162	PEP synthetase regulatory protein; Provisional; Region: PRK05339
1407053005163	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1407053005164	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14267
1407053005165	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1407053005166	Walker A/P-loop; other site
1407053005167	ATP binding site [chemical binding]; other site
1407053005168	Q-loop/lid; other site
1407053005169	ABC transporter signature motif; other site
1407053005170	Walker B; other site
1407053005171	D-loop; other site
1407053005172	H-loop/switch region; other site
1407053005173	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053005174	dimer interface [polypeptide binding]; other site
1407053005175	conserved gate region; other site
1407053005176	putative PBP binding loops; other site
1407053005177	ABC-ATPase subunit interface; other site
1407053005178	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1407053005179	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1407053005180	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
1407053005181	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
1407053005182	active site residue [active]
1407053005183	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
1407053005184	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1407053005185	active site
1407053005186	intersubunit interface [polypeptide binding]; other site
1407053005187	catalytic residue [active]
1407053005188	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
1407053005189	Peptidase M15; Region: Peptidase_M15_3; cl01194
1407053005190	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1407053005191	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1407053005192	active site
1407053005193	phosphorylation site [posttranslational modification]
1407053005194	intermolecular recognition site; other site
1407053005195	dimerization interface [polypeptide binding]; other site
1407053005196	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1407053005197	Walker A motif; other site
1407053005198	ATP binding site [chemical binding]; other site
1407053005199	Walker B motif; other site
1407053005200	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1407053005201	aminodeoxychorismate synthase; Provisional; Region: PRK07508
1407053005202	chorismate binding enzyme; Region: Chorismate_bind; cl10555
1407053005203	Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310
1407053005204	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
1407053005205	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1407053005206	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
1407053005207	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
1407053005208	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1407053005209	active site
1407053005210	tetramer interface; other site
1407053005211	lytic murein transglycosylase; Region: MltB_2; TIGR02283
1407053005212	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1407053005213	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1407053005214	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1407053005215	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1407053005216	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1407053005217	catalytic residue [active]
1407053005218	TrbC/VIRB2 family; Region: TrbC; pfam04956
1407053005219	Type IV secretory pathway, VirB3 components [Intracellular trafficking and secretion]; Region: VirB3; COG3702
1407053005220	Type IV secretory pathway, VirB4 components [Intracellular trafficking and secretion]; Region: VirB4; COG3451
1407053005221	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
1407053005222	Type IV secretory pathway, VirB6 components [Intracellular trafficking and secretion]; Region: VirB6; COG3704
1407053005223	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
1407053005224	Type IV secretory pathway, component VirB8 [Intracellular trafficking and secretion]; Region: VirB8; COG3736
1407053005225	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423
1407053005226	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
1407053005227	VirB7 interaction site; other site
1407053005228	Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948
1407053005229	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
1407053005230	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
1407053005231	ATP binding site [chemical binding]; other site
1407053005232	Walker A motif; other site
1407053005233	hexamer interface [polypeptide binding]; other site
1407053005234	Walker B motif; other site
1407053005235	SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829
1407053005236	active site
1407053005237	oxyanion hole [active]
1407053005238	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
1407053005239	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
1407053005240	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
1407053005241	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
1407053005242	tetramer interface [polypeptide binding]; other site
1407053005243	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1407053005244	catalytic residue [active]
1407053005245	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1407053005246	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
1407053005247	putative dimer interface [polypeptide binding]; other site
1407053005248	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
1407053005249	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1407053005250	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1407053005251	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
1407053005252	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1407053005253	active site
1407053005254	N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: HutG; COG3741
1407053005255	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1407053005256	active site
1407053005257	phosphorylation site [posttranslational modification]
1407053005258	intermolecular recognition site; other site
1407053005259	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
1407053005260	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1407053005261	active site
1407053005262	phosphorylation site [posttranslational modification]
1407053005263	intermolecular recognition site; other site
1407053005264	dimerization interface [polypeptide binding]; other site
1407053005265	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1407053005266	dimerization interface [polypeptide binding]; other site
1407053005267	DNA binding residues [nucleotide binding]
1407053005268	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1407053005269	ATP binding site [chemical binding]; other site
1407053005270	Mg2+ binding site [ion binding]; other site
1407053005271	G-X-G motif; other site
1407053005272	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1407053005273	shikimate binding site; other site
1407053005274	NAD(P) binding site [chemical binding]; other site
1407053005275	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1407053005276	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1407053005277	E3 interaction surface; other site
1407053005278	lipoyl attachment site [posttranslational modification]; other site
1407053005279	e3 binding domain; Region: E3_binding; pfam02817
1407053005280	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1407053005281	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
1407053005282	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1407053005283	tetramer interface [polypeptide binding]; other site
1407053005284	TPP-binding site [chemical binding]; other site
1407053005285	heterodimer interface [polypeptide binding]; other site
1407053005286	phosphorylation loop region [posttranslational modification]
1407053005287	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
1407053005288	PYR/PP interface [polypeptide binding]; other site
1407053005289	dimer interface [polypeptide binding]; other site
1407053005290	TPP binding site [chemical binding]; other site
1407053005291	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1407053005292	classical (c) SDRs; Region: SDR_c; cd05233
1407053005293	NAD(P) binding site [chemical binding]; other site
1407053005294	active site
1407053005295	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1407053005296	classical (c) SDRs; Region: SDR_c; cd05233
1407053005297	NAD(P) binding site [chemical binding]; other site
1407053005298	active site
1407053005299	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1407053005300	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1407053005301	active site
1407053005302	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1407053005303	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1407053005304	TM-ABC transporter signature motif; other site
1407053005305	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1407053005306	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1407053005307	DNA-binding site [nucleotide binding]; DNA binding site
1407053005308	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1407053005309	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4944
1407053005310	RNA polymerase sigma factor; Provisional; Region: PRK12539
1407053005311	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1407053005312	pentapeptide MXKDX repeat protein; Region: penta_MxKDx; TIGR02953
1407053005313	Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117
1407053005314	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
1407053005315	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
1407053005316	bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108
1407053005317	Moco binding site; other site
1407053005318	metal coordination site [ion binding]; other site
1407053005319	Condensation domain; Region: Condensation; pfam00668
1407053005320	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
1407053005321	isochorismate synthases; Region: isochor_syn; TIGR00543
1407053005322	Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013
1407053005323	hydrophobic substrate binding pocket; other site
1407053005324	Isochorismatase family; Region: Isochorismatase; pfam00857
1407053005325	active site
1407053005326	conserved cis-peptide bond; other site
1407053005327	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
1407053005328	2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220
1407053005329	2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331
1407053005330	putative NAD(P) binding site [chemical binding]; other site
1407053005331	active site
1407053005332	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
1407053005333	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
1407053005334	Predicted secreted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5664
1407053005335	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
1407053005336	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
1407053005337	ligand binding site [chemical binding]; other site
1407053005338	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1407053005339	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1407053005340	Walker A/P-loop; other site
1407053005341	ATP binding site [chemical binding]; other site
1407053005342	Q-loop/lid; other site
1407053005343	ABC transporter signature motif; other site
1407053005344	Walker B; other site
1407053005345	D-loop; other site
1407053005346	H-loop/switch region; other site
1407053005347	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1407053005348	Walker A/P-loop; other site
1407053005349	ATP binding site [chemical binding]; other site
1407053005350	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1407053005351	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1407053005352	TM-ABC transporter signature motif; other site
1407053005353	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
1407053005354	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1407053005355	TM-ABC transporter signature motif; other site
1407053005356	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1407053005357	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1407053005358	substrate binding site [chemical binding]; other site
1407053005359	dimer interface [polypeptide binding]; other site
1407053005360	ATP binding site [chemical binding]; other site
1407053005361	replication initiation protein RepC; Provisional; Region: PRK13824
1407053005362	Replication protein C N-terminal domain; Region: RP-C; pfam03428
1407053005363	Replication protein C C-terminal region; Region: RP-C_C; pfam11800
1407053005364	plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454
1407053005365	ParB-like nuclease domain; Region: ParB; smart00470
1407053005366	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
1407053005367	MerR family regulatory protein; Region: MerR; pfam00376
1407053005368	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1407053005369	P-loop; other site
1407053005370	Magnesium ion binding site [ion binding]; other site
1407053005371	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1407053005372	P-loop; other site
1407053005373	Magnesium ion binding site [ion binding]; other site
1407053005374	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
1407053005375	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1407053005376	FeS/SAM binding site; other site
1407053005377	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
1407053005378	HemN C-terminal domain; Region: HemN_C; pfam06969
1407053005379	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
1407053005380	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1407053005381	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1407053005382	Walker A/P-loop; other site
1407053005383	ATP binding site [chemical binding]; other site
1407053005384	Q-loop/lid; other site
1407053005385	ABC transporter signature motif; other site
1407053005386	Walker B; other site
1407053005387	D-loop; other site
1407053005388	H-loop/switch region; other site
1407053005389	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1407053005390	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1407053005391	Walker A/P-loop; other site
1407053005392	ATP binding site [chemical binding]; other site
1407053005393	Q-loop/lid; other site
1407053005394	ABC transporter signature motif; other site
1407053005395	Walker B; other site
1407053005396	D-loop; other site
1407053005397	H-loop/switch region; other site
1407053005398	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
1407053005399	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1407053005400	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_5; cd06338
1407053005401	putative ligand binding site [chemical binding]; other site
1407053005402	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1407053005403	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1407053005404	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
1407053005405	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1407053005406	N-terminal plug; other site
1407053005407	ligand-binding site [chemical binding]; other site
1407053005408	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1407053005409	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1407053005410	nucleotide binding site [chemical binding]; other site
1407053005411	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1407053005412	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053005413	dimer interface [polypeptide binding]; other site
1407053005414	conserved gate region; other site
1407053005415	putative PBP binding loops; other site
1407053005416	ABC-ATPase subunit interface; other site
1407053005417	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1407053005418	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1407053005419	Walker A/P-loop; other site
1407053005420	ATP binding site [chemical binding]; other site
1407053005421	Q-loop/lid; other site
1407053005422	ABC transporter signature motif; other site
1407053005423	Walker B; other site
1407053005424	D-loop; other site
1407053005425	H-loop/switch region; other site
1407053005426	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1407053005427	NMT1-like family; Region: NMT1_2; pfam13379
1407053005428	substrate binding pocket [chemical binding]; other site
1407053005429	membrane-bound complex binding site; other site
1407053005430	hinge residues; other site
1407053005431	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1407053005432	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1407053005433	active site
1407053005434	metal binding site [ion binding]; metal-binding site
1407053005435	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1407053005436	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1407053005437	Walker A/P-loop; other site
1407053005438	ATP binding site [chemical binding]; other site
1407053005439	Q-loop/lid; other site
1407053005440	ABC transporter signature motif; other site
1407053005441	Walker B; other site
1407053005442	D-loop; other site
1407053005443	H-loop/switch region; other site
1407053005444	TOBE domain; Region: TOBE_2; pfam08402
1407053005445	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1407053005446	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1407053005447	DNA-binding site [nucleotide binding]; DNA binding site
1407053005448	UTRA domain; Region: UTRA; pfam07702
1407053005449	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1407053005450	Protein of unknown function (DUF1634); Region: DUF1634; pfam07843
1407053005451	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1407053005452	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1407053005453	Walker A/P-loop; other site
1407053005454	ATP binding site [chemical binding]; other site
1407053005455	Q-loop/lid; other site
1407053005456	ABC transporter signature motif; other site
1407053005457	Walker B; other site
1407053005458	D-loop; other site
1407053005459	H-loop/switch region; other site
1407053005460	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1407053005461	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1407053005462	TM-ABC transporter signature motif; other site
1407053005463	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1407053005464	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1407053005465	Walker A/P-loop; other site
1407053005466	ATP binding site [chemical binding]; other site
1407053005467	Q-loop/lid; other site
1407053005468	ABC transporter signature motif; other site
1407053005469	Walker B; other site
1407053005470	D-loop; other site
1407053005471	H-loop/switch region; other site
1407053005472	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1407053005473	TM-ABC transporter signature motif; other site
1407053005474	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1407053005475	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
1407053005476	putative ligand binding site [chemical binding]; other site
1407053005477	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
1407053005478	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
1407053005479	active site
1407053005480	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1407053005481	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
1407053005482	NAD(P) binding site [chemical binding]; other site
1407053005483	catalytic residues [active]
1407053005484	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1407053005485	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1407053005486	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1407053005487	Bacterial transcriptional regulator; Region: IclR; pfam01614
1407053005488	Uncharacterized conserved protein [Function unknown]; Region: COG5441; cl02262
1407053005489	Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792
1407053005490	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
1407053005491	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1407053005492	motif II; other site
1407053005493	hypothetical protein; Provisional; Region: PRK07481
1407053005494	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1407053005495	inhibitor-cofactor binding pocket; inhibition site
1407053005496	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1407053005497	catalytic residue [active]
1407053005498	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
1407053005499	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1407053005500	inhibitor-cofactor binding pocket; inhibition site
1407053005501	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1407053005502	catalytic residue [active]
1407053005503	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
1407053005504	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1407053005505	active site
1407053005506	ATP binding site [chemical binding]; other site
1407053005507	substrate binding site [chemical binding]; other site
1407053005508	homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337
1407053005509	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1407053005510	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
1407053005511	putative substrate binding pocket [chemical binding]; other site
1407053005512	trimer interface [polypeptide binding]; other site
1407053005513	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299
1407053005514	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
1407053005515	NAD binding site [chemical binding]; other site
1407053005516	catalytic residues [active]
1407053005517	3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295
1407053005518	N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266
1407053005519	tetramer interface [polypeptide binding]; other site
1407053005520	C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256
1407053005521	tetramer interface [polypeptide binding]; other site
1407053005522	active site
1407053005523	metal binding site [ion binding]; metal-binding site
1407053005524	2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312
1407053005525	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Region: HpaI; TIGR02311
1407053005526	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1407053005527	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
1407053005528	HTH domain; Region: HTH_11; cl17392
1407053005529	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1407053005530	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1407053005531	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1407053005532	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1407053005533	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1407053005534	TM-ABC transporter signature motif; other site
1407053005535	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
1407053005536	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1407053005537	Walker A/P-loop; other site
1407053005538	ATP binding site [chemical binding]; other site
1407053005539	Q-loop/lid; other site
1407053005540	ABC transporter signature motif; other site
1407053005541	Walker B; other site
1407053005542	D-loop; other site
1407053005543	H-loop/switch region; other site
1407053005544	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1407053005545	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
1407053005546	D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634
1407053005547	putative ligand binding site [chemical binding]; other site
1407053005548	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
1407053005549	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
1407053005550	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
1407053005551	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
1407053005552	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
1407053005553	Autotransporter beta-domain; Region: Autotransporter; pfam03797
1407053005554	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1407053005555	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
1407053005556	flagellar motor protein MotB; Validated; Region: motB; PRK05996
1407053005557	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
1407053005558	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1407053005559	ligand binding site [chemical binding]; other site
1407053005560	chemotaxis protein; Reviewed; Region: PRK12798
1407053005561	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
1407053005562	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1407053005563	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1407053005564	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1407053005565	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
1407053005566	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1407053005567	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
1407053005568	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1407053005569	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521
1407053005570	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1407053005571	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008
1407053005572	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1407053005573	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1407053005574	Flagellar biosynthesis regulator FlaF [Cell motility and secretion]; Region: FlaF; COG5442
1407053005575	flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793
1407053005576	Flagellar biosynthesis regulator FlbT [Cell motility and secretion]; Region: FlbT; COG5443
1407053005577	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009
1407053005578	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
1407053005579	flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010
1407053005580	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980
1407053005581	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
1407053005582	Rod binding protein; Region: Rod-binding; pfam10135
1407053005583	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1407053005584	metal binding site 2 [ion binding]; metal-binding site
1407053005585	putative DNA binding helix; other site
1407053005586	metal binding site 1 [ion binding]; metal-binding site
1407053005587	dimer interface [polypeptide binding]; other site
1407053005588	structural Zn2+ binding site [ion binding]; other site
1407053005589	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1407053005590	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1407053005591	ABC-ATPase subunit  interface; other site
1407053005592	dimer interface [polypeptide binding]; other site
1407053005593	putative PBP binding regions; other site
1407053005594	ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531
1407053005595	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
1407053005596	metal binding site [ion binding]; metal-binding site
1407053005597	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1407053005598	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1407053005599	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1407053005600	Rrf2 family protein; Region: rrf2_super; TIGR00738
1407053005601	Transcriptional regulator; Region: Rrf2; pfam02082
1407053005602	Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971
1407053005603	putative transposase OrfB; Reviewed; Region: PHA02517
1407053005604	HTH-like domain; Region: HTH_21; pfam13276
1407053005605	Integrase core domain; Region: rve; pfam00665
1407053005606	Integrase core domain; Region: rve_3; pfam13683
1407053005607	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
1407053005608	Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337
1407053005609	Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235
1407053005610	intersubunit interface [polypeptide binding]; other site
1407053005611	active site
1407053005612	Zn2+ binding site [ion binding]; other site
1407053005613	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1407053005614	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053005615	dimer interface [polypeptide binding]; other site
1407053005616	conserved gate region; other site
1407053005617	putative PBP binding loops; other site
1407053005618	ABC-ATPase subunit interface; other site
1407053005619	amidase; Provisional; Region: PRK07486
1407053005620	Amidase; Region: Amidase; cl11426
1407053005621	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1407053005622	Walker A/P-loop; other site
1407053005623	ATP binding site [chemical binding]; other site
1407053005624	Q-loop/lid; other site
1407053005625	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1407053005626	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1407053005627	Walker A/P-loop; other site
1407053005628	ATP binding site [chemical binding]; other site
1407053005629	Q-loop/lid; other site
1407053005630	ABC transporter signature motif; other site
1407053005631	Walker B; other site
1407053005632	D-loop; other site
1407053005633	H-loop/switch region; other site
1407053005634	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1407053005635	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1407053005636	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053005637	dimer interface [polypeptide binding]; other site
1407053005638	conserved gate region; other site
1407053005639	putative PBP binding loops; other site
1407053005640	ABC-ATPase subunit interface; other site
1407053005641	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1407053005642	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
1407053005643	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1407053005644	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
1407053005645	DNA-binding site [nucleotide binding]; DNA binding site
1407053005646	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1407053005647	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1407053005648	Walker A/P-loop; other site
1407053005649	ATP binding site [chemical binding]; other site
1407053005650	Q-loop/lid; other site
1407053005651	ABC transporter signature motif; other site
1407053005652	Walker B; other site
1407053005653	D-loop; other site
1407053005654	H-loop/switch region; other site
1407053005655	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1407053005656	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1407053005657	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053005658	dimer interface [polypeptide binding]; other site
1407053005659	conserved gate region; other site
1407053005660	putative PBP binding loops; other site
1407053005661	ABC-ATPase subunit interface; other site
1407053005662	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1407053005663	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053005664	dimer interface [polypeptide binding]; other site
1407053005665	conserved gate region; other site
1407053005666	putative PBP binding loops; other site
1407053005667	ABC-ATPase subunit interface; other site
1407053005668	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
1407053005669	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1407053005670	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1407053005671	active site
1407053005672	3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268
1407053005673	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1407053005674	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1407053005675	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1407053005676	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1407053005677	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
1407053005678	acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875
1407053005679	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1407053005680	E3 interaction surface; other site
1407053005681	lipoyl attachment site [posttranslational modification]; other site
1407053005682	e3 binding domain; Region: E3_binding; pfam02817
1407053005683	Serine hydrolase; Region: Ser_hydrolase; cl17834
1407053005684	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1407053005685	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1407053005686	Bacterial transcriptional regulator; Region: IclR; pfam01614
1407053005687	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1407053005688	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053005689	dimer interface [polypeptide binding]; other site
1407053005690	conserved gate region; other site
1407053005691	putative PBP binding loops; other site
1407053005692	ABC-ATPase subunit interface; other site
1407053005693	nickel transporter permease NikC; Provisional; Region: nikC; PRK10417
1407053005694	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
1407053005695	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1407053005696	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1407053005697	Walker A/P-loop; other site
1407053005698	ATP binding site [chemical binding]; other site
1407053005699	Q-loop/lid; other site
1407053005700	ABC transporter signature motif; other site
1407053005701	Walker B; other site
1407053005702	D-loop; other site
1407053005703	H-loop/switch region; other site
1407053005704	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1407053005705	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
1407053005706	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1407053005707	Walker A/P-loop; other site
1407053005708	ATP binding site [chemical binding]; other site
1407053005709	Q-loop/lid; other site
1407053005710	ABC transporter signature motif; other site
1407053005711	Walker B; other site
1407053005712	D-loop; other site
1407053005713	H-loop/switch region; other site
1407053005714	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1407053005715	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1407053005716	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1407053005717	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1407053005718	tetramerization interface [polypeptide binding]; other site
1407053005719	NAD(P) binding site [chemical binding]; other site
1407053005720	catalytic residues [active]
1407053005721	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1407053005722	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1407053005723	DNA-binding site [nucleotide binding]; DNA binding site
1407053005724	FCD domain; Region: FCD; pfam07729
1407053005725	putative transposase OrfB; Reviewed; Region: PHA02517
1407053005726	HTH-like domain; Region: HTH_21; pfam13276
1407053005727	Integrase core domain; Region: rve; pfam00665
1407053005728	Integrase core domain; Region: rve_3; pfam13683
1407053005729	methionine sulfoxide reductase A; Provisional; Region: PRK00058
1407053005730	hypothetical protein; Provisional; Region: PRK00736
1407053005731	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1407053005732	active site
1407053005733	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
1407053005734	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1407053005735	S-adenosylmethionine binding site [chemical binding]; other site
1407053005736	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
1407053005737	ABC1 family; Region: ABC1; pfam03109
1407053005738	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1407053005739	active site
1407053005740	ATP binding site [chemical binding]; other site
1407053005741	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1407053005742	substrate binding site [chemical binding]; other site
1407053005743	activation loop (A-loop); other site
1407053005744	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1407053005745	Flavoprotein; Region: Flavoprotein; pfam02441
1407053005746	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
1407053005747	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1407053005748	G1 box; other site
1407053005749	GTP/Mg2+ binding site [chemical binding]; other site
1407053005750	G2 box; other site
1407053005751	Switch I region; other site
1407053005752	G3 box; other site
1407053005753	Switch II region; other site
1407053005754	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
1407053005755	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
1407053005756	Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157
1407053005757	putative active site [active]
1407053005758	catalytic site [active]
1407053005759	Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163
1407053005760	putative active site [active]
1407053005761	catalytic site [active]
1407053005762	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
1407053005763	putative catalytic site [active]
1407053005764	putative metal binding site [ion binding]; other site
1407053005765	putative phosphate binding site [ion binding]; other site
1407053005766	Predicted membrane protein [Function unknown]; Region: COG3714
1407053005767	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1407053005768	Ligand Binding Site [chemical binding]; other site
1407053005769	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
1407053005770	putative FMN binding site [chemical binding]; other site
1407053005771	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
1407053005772	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
1407053005773	active site
1407053005774	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1407053005775	catalytic core [active]
1407053005776	Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289
1407053005777	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1407053005778	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1407053005779	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1407053005780	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1407053005781	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1407053005782	Walker A/P-loop; other site
1407053005783	ATP binding site [chemical binding]; other site
1407053005784	Q-loop/lid; other site
1407053005785	ABC transporter signature motif; other site
1407053005786	Walker B; other site
1407053005787	D-loop; other site
1407053005788	H-loop/switch region; other site
1407053005789	Glucokinase [Carbohydrate transport and metabolism]; Region: Glk; COG0837
1407053005790	glucokinase, proteobacterial type; Region: glk; TIGR00749
1407053005791	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
1407053005792	active site
1407053005793	dimer interfaces [polypeptide binding]; other site
1407053005794	catalytic residues [active]
1407053005795	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
1407053005796	Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770
1407053005797	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1407053005798	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
1407053005799	putative NAD(P) binding site [chemical binding]; other site
1407053005800	epoxyqueuosine reductase; Region: TIGR00276
1407053005801	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
1407053005802	HEAT repeat; Region: HEAT; pfam02985
1407053005803	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1407053005804	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
1407053005805	C-terminal domain interface [polypeptide binding]; other site
1407053005806	GSH binding site (G-site) [chemical binding]; other site
1407053005807	dimer interface [polypeptide binding]; other site
1407053005808	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
1407053005809	N-terminal domain interface [polypeptide binding]; other site
1407053005810	dimer interface [polypeptide binding]; other site
1407053005811	substrate binding pocket (H-site) [chemical binding]; other site
1407053005812	Undecaprenyl pyrophosphate phosphatase [Lipid transport and metabolism]; Region: BacA; COG1968
1407053005813	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1407053005814	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
1407053005815	putative NAD(P) binding site [chemical binding]; other site
1407053005816	active site
1407053005817	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
1407053005818	GIY-YIG motif/motif A; other site
1407053005819	putative active site [active]
1407053005820	putative metal binding site [ion binding]; other site
1407053005821	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
1407053005822	RmuC family; Region: RmuC; pfam02646
1407053005823	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1407053005824	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1407053005825	putative active site [active]
1407053005826	substrate binding site [chemical binding]; other site
1407053005827	putative cosubstrate binding site; other site
1407053005828	catalytic site [active]
1407053005829	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1407053005830	substrate binding site [chemical binding]; other site
1407053005831	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1407053005832	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1407053005833	dimerization interface 3.5A [polypeptide binding]; other site
1407053005834	active site
1407053005835	Predicted transglutaminase-like cysteine proteinase [General    function prediction only]; Region: COG3672
1407053005836	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
1407053005837	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
1407053005838	homohexameric interface [polypeptide binding]; other site
1407053005839	feedback inhibition sensing region; other site
1407053005840	nucleotide binding site [chemical binding]; other site
1407053005841	N-acetyl-L-glutamate binding site [chemical binding]; other site
1407053005842	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
1407053005843	G1 box; other site
1407053005844	GTP/Mg2+ binding site [chemical binding]; other site
1407053005845	Switch I region; other site
1407053005846	G2 box; other site
1407053005847	G3 box; other site
1407053005848	Switch II region; other site
1407053005849	G4 box; other site
1407053005850	G5 box; other site
1407053005851	membrane protein insertase; Provisional; Region: PRK01318
1407053005852	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
1407053005853	ribonuclease P; Reviewed; Region: rnpA; PRK01313
1407053005854	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
1407053005855	homotrimer interaction site [polypeptide binding]; other site
1407053005856	putative active site [active]
1407053005857	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1407053005858	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1407053005859	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1407053005860	DNA-binding site [nucleotide binding]; DNA binding site
1407053005861	FCD domain; Region: FCD; pfam07729
1407053005862	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1407053005863	Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109
1407053005864	NAD(P) binding site [chemical binding]; other site
1407053005865	catalytic residues [active]
1407053005866	catalytic residues [active]
1407053005867	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345
1407053005868	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
1407053005869	putative NAD(P) binding site [chemical binding]; other site
1407053005870	active site
1407053005871	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1407053005872	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494
1407053005873	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1407053005874	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053005875	dimer interface [polypeptide binding]; other site
1407053005876	conserved gate region; other site
1407053005877	putative PBP binding loops; other site
1407053005878	ABC-ATPase subunit interface; other site
1407053005879	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
1407053005880	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053005881	dimer interface [polypeptide binding]; other site
1407053005882	conserved gate region; other site
1407053005883	putative PBP binding loops; other site
1407053005884	ABC-ATPase subunit interface; other site
1407053005885	amidase; Provisional; Region: PRK07042
1407053005886	Amidase; Region: Amidase; cl11426
1407053005887	DNA polymerase III subunit epsilon; Validated; Region: PRK09182
1407053005888	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
1407053005889	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1407053005890	active site
1407053005891	catalytic site [active]
1407053005892	substrate binding site [chemical binding]; other site
1407053005893	glutathionine S-transferase; Provisional; Region: PRK10542
1407053005894	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
1407053005895	C-terminal domain interface [polypeptide binding]; other site
1407053005896	GSH binding site (G-site) [chemical binding]; other site
1407053005897	dimer interface [polypeptide binding]; other site
1407053005898	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
1407053005899	dimer interface [polypeptide binding]; other site
1407053005900	N-terminal domain interface [polypeptide binding]; other site
1407053005901	substrate binding pocket (H-site) [chemical binding]; other site
1407053005902	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
1407053005903	dimer interface [polypeptide binding]; other site
1407053005904	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
1407053005905	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1407053005906	N-terminal plug; other site
1407053005907	ligand-binding site [chemical binding]; other site
1407053005908	Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300
1407053005909	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1407053005910	putative ligand binding site [chemical binding]; other site
1407053005911	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1407053005912	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1407053005913	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1407053005914	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1407053005915	TM-ABC transporter signature motif; other site
1407053005916	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
1407053005917	homotrimer interaction site [polypeptide binding]; other site
1407053005918	putative active site [active]
1407053005919	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
1407053005920	TMAO/DMSO reductase; Reviewed; Region: PRK05363
1407053005921	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
1407053005922	Moco binding site; other site
1407053005923	metal coordination site [ion binding]; other site
1407053005924	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1407053005925	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
1407053005926	structural tetrad; other site
1407053005927	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1407053005928	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
1407053005929	P-loop, Walker A motif; other site
1407053005930	Base recognition motif; other site
1407053005931	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1407053005932	Creatinine amidohydrolase; Region: Creatininase; pfam02633
1407053005933	MarR family; Region: MarR_2; cl17246
1407053005934	transcriptional regulator SlyA; Provisional; Region: PRK03573
1407053005935	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1407053005936	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1407053005937	DNA binding site [nucleotide binding]
1407053005938	domain linker motif; other site
1407053005939	Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289
1407053005940	putative dimerization interface [polypeptide binding]; other site
1407053005941	putative ligand binding site [chemical binding]; other site
1407053005942	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1407053005943	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
1407053005944	putative ligand binding site [chemical binding]; other site
1407053005945	NAD binding site [chemical binding]; other site
1407053005946	catalytic site [active]
1407053005947	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
1407053005948	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
1407053005949	catalytic triad [active]
1407053005950	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
1407053005951	classical (c) SDRs; Region: SDR_c; cd05233
1407053005952	NAD(P) binding site [chemical binding]; other site
1407053005953	active site
1407053005954	PAS fold; Region: PAS_7; pfam12860
1407053005955	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1407053005956	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1407053005957	metal binding site [ion binding]; metal-binding site
1407053005958	active site
1407053005959	I-site; other site
1407053005960	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1407053005961	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1407053005962	Beta-lactamase; Region: Beta-lactamase; pfam00144
1407053005963	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
1407053005964	Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835
1407053005965	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
1407053005966	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
1407053005967	ligand binding site [chemical binding]; other site
1407053005968	homodimer interface [polypeptide binding]; other site
1407053005969	NAD(P) binding site [chemical binding]; other site
1407053005970	trimer interface B [polypeptide binding]; other site
1407053005971	trimer interface A [polypeptide binding]; other site
1407053005972	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
1407053005973	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
1407053005974	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
1407053005975	Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091
1407053005976	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1407053005977	SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616
1407053005978	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
1407053005979	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1407053005980	motif II; other site
1407053005981	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
1407053005982	putative active site [active]
1407053005983	putative catalytic site [active]
1407053005984	Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990
1407053005985	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
1407053005986	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1407053005987	TPR repeat; Region: TPR_11; pfam13414
1407053005988	TPR motif; other site
1407053005989	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1407053005990	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
1407053005991	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1407053005992	ABC transporter signature motif; other site
1407053005993	Walker B; other site
1407053005994	D-loop; other site
1407053005995	H-loop/switch region; other site
1407053005996	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
1407053005997	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053005998	dimer interface [polypeptide binding]; other site
1407053005999	conserved gate region; other site
1407053006000	ABC-ATPase subunit interface; other site
1407053006001	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1407053006002	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1407053006003	choline dehydrogenase; Validated; Region: PRK02106
1407053006004	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1407053006005	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1407053006006	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1407053006007	TM-ABC transporter signature motif; other site
1407053006008	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1407053006009	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1407053006010	TM-ABC transporter signature motif; other site
1407053006011	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1407053006012	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1407053006013	Walker A/P-loop; other site
1407053006014	ATP binding site [chemical binding]; other site
1407053006015	Q-loop/lid; other site
1407053006016	ABC transporter signature motif; other site
1407053006017	Walker B; other site
1407053006018	D-loop; other site
1407053006019	H-loop/switch region; other site
1407053006020	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1407053006021	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1407053006022	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
1407053006023	putative ligand binding site [chemical binding]; other site
1407053006024	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1407053006025	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1407053006026	LysR substrate binding domain; Region: LysR_substrate; pfam03466
1407053006027	dimerization interface [polypeptide binding]; other site
1407053006028	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1407053006029	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
1407053006030	AsnC family; Region: AsnC_trans_reg; pfam01037
1407053006031	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
1407053006032	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1407053006033	substrate binding pocket [chemical binding]; other site
1407053006034	membrane-bound complex binding site; other site
1407053006035	hinge residues; other site
1407053006036	D-aminopeptidase; Reviewed; Region: PRK13128
1407053006037	Beta-lactamase; Region: Beta-lactamase; pfam00144
1407053006038	D-aminopeptidase, domain B; Region: DAP_B; pfam07930
1407053006039	D-aminopeptidase, domain C; Region: DAP_C; pfam07932
1407053006040	thiamine pyrophosphate protein; Validated; Region: PRK08199
1407053006041	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1407053006042	PYR/PP interface [polypeptide binding]; other site
1407053006043	dimer interface [polypeptide binding]; other site
1407053006044	TPP binding site [chemical binding]; other site
1407053006045	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1407053006046	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
1407053006047	TPP-binding site [chemical binding]; other site
1407053006048	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1407053006049	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1407053006050	DNA-binding site [nucleotide binding]; DNA binding site
1407053006051	FCD domain; Region: FCD; pfam07729
1407053006052	Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802
1407053006053	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
1407053006054	dihydroxy-acid dehydratase; Provisional; Region: PRK13017
1407053006055	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
1407053006056	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
1407053006057	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
1407053006058	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1407053006059	active site
1407053006060	intersubunit interface [polypeptide binding]; other site
1407053006061	catalytic residue [active]
1407053006062	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
1407053006063	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
1407053006064	putative ligand binding site [chemical binding]; other site
1407053006065	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1407053006066	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1407053006067	Walker A/P-loop; other site
1407053006068	ATP binding site [chemical binding]; other site
1407053006069	Q-loop/lid; other site
1407053006070	ABC transporter signature motif; other site
1407053006071	Walker B; other site
1407053006072	D-loop; other site
1407053006073	H-loop/switch region; other site
1407053006074	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1407053006075	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1407053006076	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
1407053006077	homodimer interface [polypeptide binding]; other site
1407053006078	substrate-cofactor binding pocket; other site
1407053006079	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1407053006080	catalytic residue [active]
1407053006081	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3758
1407053006082	urocanate hydratase; Provisional; Region: PRK05414
1407053006083	N-formylglutamate amidohydrolase; Region: hutG_amidohyd; TIGR02017
1407053006084	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
1407053006085	tetramer interface [polypeptide binding]; other site
1407053006086	imidazolonepropionase; Validated; Region: PRK09356
1407053006087	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
1407053006088	active site
1407053006089	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
1407053006090	Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313
1407053006091	active site
1407053006092	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
1407053006093	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1407053006094	DNA-binding site [nucleotide binding]; DNA binding site
1407053006095	UTRA domain; Region: UTRA; pfam07702
1407053006096	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
1407053006097	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1407053006098	inhibitor-cofactor binding pocket; inhibition site
1407053006099	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1407053006100	catalytic residue [active]
1407053006101	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
1407053006102	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1407053006103	non-specific DNA binding site [nucleotide binding]; other site
1407053006104	salt bridge; other site
1407053006105	sequence-specific DNA binding site [nucleotide binding]; other site
1407053006106	Cupin domain; Region: Cupin_2; pfam07883
1407053006107	D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409
1407053006108	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1407053006109	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1407053006110	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
1407053006111	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1407053006112	active site
1407053006113	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1407053006114	dimer interface [polypeptide binding]; other site
1407053006115	substrate binding site [chemical binding]; other site
1407053006116	catalytic residues [active]
1407053006117	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1407053006118	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1407053006119	putative DNA binding site [nucleotide binding]; other site
1407053006120	putative Zn2+ binding site [ion binding]; other site
1407053006121	AsnC family; Region: AsnC_trans_reg; pfam01037
1407053006122	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
1407053006123	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1407053006124	phosphate binding site [ion binding]; other site
1407053006125	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
1407053006126	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
1407053006127	putative molybdopterin cofactor binding site [chemical binding]; other site
1407053006128	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
1407053006129	putative molybdopterin cofactor binding site; other site
1407053006130	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1407053006131	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1407053006132	HlyD family secretion protein; Region: HlyD_3; pfam13437
1407053006133	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1407053006134	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1407053006135	HlyD family secretion protein; Region: HlyD_3; pfam13437
1407053006136	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1407053006137	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1407053006138	DNA-binding site [nucleotide binding]; DNA binding site
1407053006139	UTRA domain; Region: UTRA; pfam07702
1407053006140	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
1407053006141	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1407053006142	dimer interface [polypeptide binding]; other site
1407053006143	active site
1407053006144	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1407053006145	dimer interface [polypeptide binding]; other site
1407053006146	active site
1407053006147	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
1407053006148	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
1407053006149	active site
1407053006150	dimer interface [polypeptide binding]; other site
1407053006151	hypothetical protein; Provisional; Region: PRK02947
1407053006152	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1407053006153	putative active site [active]
1407053006154	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
1407053006155	aldehyde dehydrogenase family 7 member; Region: PLN02315
1407053006156	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
1407053006157	tetrameric interface [polypeptide binding]; other site
1407053006158	NAD binding site [chemical binding]; other site
1407053006159	catalytic residues [active]
1407053006160	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1407053006161	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1407053006162	putative Zn2+ binding site [ion binding]; other site
1407053006163	putative DNA binding site [nucleotide binding]; other site
1407053006164	dimerization interface [polypeptide binding]; other site
1407053006165	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1407053006166	dimerization interface [polypeptide binding]; other site
1407053006167	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1407053006168	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1407053006169	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
1407053006170	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
1407053006171	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
1407053006172	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
1407053006173	RNA binding site [nucleotide binding]; other site
1407053006174	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1407053006175	dimerization interface [polypeptide binding]; other site
1407053006176	putative DNA binding site [nucleotide binding]; other site
1407053006177	putative Zn2+ binding site [ion binding]; other site
1407053006178	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1407053006179	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
1407053006180	active site
1407053006181	FMN binding site [chemical binding]; other site
1407053006182	substrate binding site [chemical binding]; other site
1407053006183	catalytic residue [active]
1407053006184	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1407053006185	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
1407053006186	AsnC family; Region: AsnC_trans_reg; pfam01037
1407053006187	Arginase family; Region: Arginase; cd09989
1407053006188	agmatinase; Region: agmatinase; TIGR01230
1407053006189	active site
1407053006190	Mn binding site [ion binding]; other site
1407053006191	oligomer interface [polypeptide binding]; other site
1407053006192	ornithine cyclodeaminase; Validated; Region: PRK07589
1407053006193	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
1407053006194	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
1407053006195	apolar tunnel; other site
1407053006196	heme binding site [chemical binding]; other site
1407053006197	dimerization interface [polypeptide binding]; other site
1407053006198	This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335
1407053006199	putative deacylase active site [active]
1407053006200	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
1407053006201	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
1407053006202	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1407053006203	catalytic residues [active]
1407053006204	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
1407053006205	Uncharacterized conserved protein [Function unknown]; Region: COG2835
1407053006206	tartrate dehydrogenase; Region: TTC; TIGR02089
1407053006207	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
1407053006208	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
1407053006209	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
1407053006210	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1407053006211	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1407053006212	DNA binding site [nucleotide binding]
1407053006213	active site
1407053006214	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
1407053006215	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1407053006216	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1407053006217	MarR family; Region: MarR; pfam01047
1407053006218	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
1407053006219	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
1407053006220	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
1407053006221	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1407053006222	substrate binding site [chemical binding]; other site
1407053006223	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
1407053006224	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1407053006225	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
1407053006226	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
1407053006227	active site
1407053006228	Zn binding site [ion binding]; other site
1407053006229	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
1407053006230	MgtE intracellular N domain; Region: MgtE_N; pfam03448
1407053006231	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1407053006232	Divalent cation transporter; Region: MgtE; pfam01769
1407053006233	Uncharacterized conserved protein [Function unknown]; Region: COG1739
1407053006234	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1407053006235	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
1407053006236	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
1407053006237	AMP binding site [chemical binding]; other site
1407053006238	metal binding site [ion binding]; metal-binding site
1407053006239	active site
1407053006240	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1407053006241	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1407053006242	intersubunit interface [polypeptide binding]; other site
1407053006243	active site
1407053006244	zinc binding site [ion binding]; other site
1407053006245	Na+ binding site [ion binding]; other site
1407053006246	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
1407053006247	triosephosphate isomerase; Provisional; Region: PRK14565
1407053006248	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1407053006249	substrate binding site [chemical binding]; other site
1407053006250	dimer interface [polypeptide binding]; other site
1407053006251	catalytic triad [active]
1407053006252	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1407053006253	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1407053006254	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1407053006255	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1407053006256	PCI domain; Region: PCI; cl02111
1407053006257	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1407053006258	glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369
1407053006259	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1407053006260	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1407053006261	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1407053006262	Walker A/P-loop; other site
1407053006263	ATP binding site [chemical binding]; other site
1407053006264	Q-loop/lid; other site
1407053006265	ABC transporter signature motif; other site
1407053006266	Walker B; other site
1407053006267	D-loop; other site
1407053006268	H-loop/switch region; other site
1407053006269	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1407053006270	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1407053006271	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1407053006272	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1407053006273	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
1407053006274	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1407053006275	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1407053006276	FAD binding domain; Region: FAD_binding_4; pfam01565
1407053006277	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
1407053006278	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1407053006279	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1407053006280	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1407053006281	NAD(P) binding site [chemical binding]; other site
1407053006282	active site
1407053006283	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
1407053006284	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1407053006285	inhibitor-cofactor binding pocket; inhibition site
1407053006286	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1407053006287	catalytic residue [active]
1407053006288	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1407053006289	Protein of unknown function DUF91; Region: DUF91; cl00709
1407053006290	Uncharacterized conserved protein [Function unknown]; Region: COG3586
1407053006291	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
1407053006292	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
1407053006293	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1407053006294	ATP binding site [chemical binding]; other site
1407053006295	putative Mg++ binding site [ion binding]; other site
1407053006296	helicase superfamily c-terminal domain; Region: HELICc; smart00490
1407053006297	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
1407053006298	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1407053006299	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1407053006300	Uncharacterized phage-associated protein [Function unknown]; Region: GepA; COG3600
1407053006301	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
1407053006302	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1407053006303	FMN binding site [chemical binding]; other site
1407053006304	substrate binding site [chemical binding]; other site
1407053006305	putative catalytic residue [active]
1407053006306	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1407053006307	nucleotide binding region [chemical binding]; other site
1407053006308	ATP-binding site [chemical binding]; other site
1407053006309	DEAD/H associated; Region: DEAD_assoc; pfam08494
1407053006310	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
1407053006311	putative active site [active]
1407053006312	putative metal binding site [ion binding]; other site
1407053006313	conserved hypothetical protein; Region: alph_Pro_TM; TIGR02186
1407053006314	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1407053006315	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1407053006316	Sel1-like repeats; Region: SEL1; smart00671
1407053006317	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
1407053006318	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1407053006319	DNA binding residues [nucleotide binding]
1407053006320	putative dimer interface [polypeptide binding]; other site
1407053006321	PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993
1407053006322	camphor resistance protein CrcB; Provisional; Region: PRK14225
1407053006323	camphor resistance protein CrcB; Provisional; Region: PRK14233
1407053006324	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1407053006325	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1407053006326	HlyD family secretion protein; Region: HlyD_3; pfam13437
1407053006327	mannonate dehydratase; Region: uxuA; TIGR00695
1407053006328	mannonate dehydratase; Provisional; Region: PRK03906
1407053006329	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1407053006330	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1407053006331	DNA-binding site [nucleotide binding]; DNA binding site
1407053006332	FCD domain; Region: FCD; pfam07729
1407053006333	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
1407053006334	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1407053006335	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1407053006336	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134
1407053006337	hypothetical protein; Provisional; Region: PRK11622
1407053006338	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1407053006339	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1407053006340	Walker A/P-loop; other site
1407053006341	ATP binding site [chemical binding]; other site
1407053006342	Q-loop/lid; other site
1407053006343	ABC transporter signature motif; other site
1407053006344	Walker B; other site
1407053006345	D-loop; other site
1407053006346	H-loop/switch region; other site
1407053006347	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
1407053006348	galactarate dehydratase; Region: galactar-dH20; TIGR03248
1407053006349	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
1407053006350	nickel responsive regulator; Provisional; Region: PRK02967
1407053006351	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
1407053006352	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
1407053006353	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1407053006354	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1407053006355	nickel transporter permease NikB; Provisional; Region: PRK10352
1407053006356	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053006357	dimer interface [polypeptide binding]; other site
1407053006358	conserved gate region; other site
1407053006359	putative PBP binding loops; other site
1407053006360	ABC-ATPase subunit interface; other site
1407053006361	nickel transporter permease NikC; Provisional; Region: nikC; PRK10417
1407053006362	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053006363	dimer interface [polypeptide binding]; other site
1407053006364	conserved gate region; other site
1407053006365	putative PBP binding loops; other site
1407053006366	ABC-ATPase subunit interface; other site
1407053006367	nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418
1407053006368	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1407053006369	Walker A/P-loop; other site
1407053006370	ATP binding site [chemical binding]; other site
1407053006371	Q-loop/lid; other site
1407053006372	ABC transporter signature motif; other site
1407053006373	Walker B; other site
1407053006374	D-loop; other site
1407053006375	H-loop/switch region; other site
1407053006376	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1407053006377	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1407053006378	active site
1407053006379	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1407053006380	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1407053006381	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
1407053006382	putative dimerization interface [polypeptide binding]; other site
1407053006383	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
1407053006384	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
1407053006385	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
1407053006386	FAD binding site [chemical binding]; other site
1407053006387	substrate binding site [chemical binding]; other site
1407053006388	catalytic residues [active]
1407053006389	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
1407053006390	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
1407053006391	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1407053006392	dimer interface [polypeptide binding]; other site
1407053006393	active site
1407053006394	Predicted transcriptional regulator [Transcription]; Region: COG2932
1407053006395	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1407053006396	Catalytic site [active]
1407053006397	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
1407053006398	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
1407053006399	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1407053006400	active site
1407053006401	nucleotide binding site [chemical binding]; other site
1407053006402	HIGH motif; other site
1407053006403	KMSKS motif; other site
1407053006404	tellurite resistance protein terB; Region: terB; cd07176
1407053006405	putative metal binding site [ion binding]; other site
1407053006406	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
1407053006407	active site clefts [active]
1407053006408	zinc binding site [ion binding]; other site
1407053006409	dimer interface [polypeptide binding]; other site
1407053006410	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1407053006411	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517
1407053006412	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1407053006413	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1407053006414	Walker A/P-loop; other site
1407053006415	ATP binding site [chemical binding]; other site
1407053006416	Q-loop/lid; other site
1407053006417	ABC transporter signature motif; other site
1407053006418	Walker B; other site
1407053006419	D-loop; other site
1407053006420	H-loop/switch region; other site
1407053006421	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1407053006422	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
1407053006423	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1407053006424	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1407053006425	homodimer interface [polypeptide binding]; other site
1407053006426	NADP binding site [chemical binding]; other site
1407053006427	substrate binding site [chemical binding]; other site
1407053006428	phosphogluconate dehydratase; Validated; Region: PRK09054
1407053006429	6-phosphogluconate dehydratase; Region: edd; TIGR01196
1407053006430	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1407053006431	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
1407053006432	putative active site [active]
1407053006433	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1407053006434	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1407053006435	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1407053006436	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345
1407053006437	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
1407053006438	putative NAD(P) binding site [chemical binding]; other site
1407053006439	active site
1407053006440	drug efflux system protein MdtG; Provisional; Region: PRK09874
1407053006441	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1407053006442	putative substrate translocation pore; other site
1407053006443	Predicted membrane protein [Function unknown]; Region: COG4541
1407053006444	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
1407053006445	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1407053006446	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1407053006447	putative DNA binding site [nucleotide binding]; other site
1407053006448	putative Zn2+ binding site [ion binding]; other site
1407053006449	AsnC family; Region: AsnC_trans_reg; pfam01037
1407053006450	Hint domain; Region: Hint_2; pfam13403
1407053006451	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1407053006452	hypothetical protein; Reviewed; Region: PRK12275
1407053006453	four helix bundle protein; Region: TIGR02436
1407053006454	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1407053006455	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1407053006456	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1407053006457	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1407053006458	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1407053006459	dimerization interface [polypeptide binding]; other site
1407053006460	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1407053006461	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1407053006462	generic binding surface II; other site
1407053006463	generic binding surface I; other site
1407053006464	Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572
1407053006465	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
1407053006466	RNA methyltransferase, RsmE family; Region: TIGR00046
1407053006467	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1407053006468	MarR family; Region: MarR_2; pfam12802
1407053006469	Fusaric acid resistance protein family; Region: FUSC; pfam04632
1407053006470	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1407053006471	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1407053006472	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1407053006473	HlyD family secretion protein; Region: HlyD_3; pfam13437
1407053006474	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
1407053006475	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
1407053006476	putative ligand binding residues [chemical binding]; other site
1407053006477	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1407053006478	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1407053006479	ABC-ATPase subunit  interface; other site
1407053006480	dimer interface [polypeptide binding]; other site
1407053006481	putative PBP binding regions; other site
1407053006482	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1407053006483	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1407053006484	Walker A/P-loop; other site
1407053006485	ATP binding site [chemical binding]; other site
1407053006486	Q-loop/lid; other site
1407053006487	ABC transporter signature motif; other site
1407053006488	Walker B; other site
1407053006489	D-loop; other site
1407053006490	H-loop/switch region; other site
1407053006491	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1407053006492	EamA-like transporter family; Region: EamA; pfam00892
1407053006493	BA14K-like protein; Region: BA14K; pfam07886
1407053006494	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1407053006495	Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192
1407053006496	putative active site [active]
1407053006497	metal binding site [ion binding]; metal-binding site
1407053006498	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1407053006499	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1407053006500	Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931
1407053006501	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1407053006502	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1407053006503	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1407053006504	putative active site [active]
1407053006505	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
1407053006506	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1407053006507	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1407053006508	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
1407053006509	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
1407053006510	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1407053006511	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1407053006512	lipoyl attachment site [posttranslational modification]; other site
1407053006513	glycine dehydrogenase; Provisional; Region: PRK05367
1407053006514	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1407053006515	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1407053006516	catalytic residue [active]
1407053006517	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1407053006518	tetramer interface [polypeptide binding]; other site
1407053006519	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1407053006520	catalytic residue [active]
1407053006521	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
1407053006522	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1407053006523	putative DNA binding site [nucleotide binding]; other site
1407053006524	putative Zn2+ binding site [ion binding]; other site
1407053006525	AsnC family; Region: AsnC_trans_reg; pfam01037
1407053006526	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
1407053006527	delta-1-pyrroline-5-carboxylate dehydrogenase (PutA C-terminal domain); Region: D1pyr5carbox3; TIGR01238
1407053006528	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
1407053006529	Glutamate binding site [chemical binding]; other site
1407053006530	NAD binding site [chemical binding]; other site
1407053006531	catalytic residues [active]
1407053006532	2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046
1407053006533	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1407053006534	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1407053006535	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053006536	dimer interface [polypeptide binding]; other site
1407053006537	conserved gate region; other site
1407053006538	putative PBP binding loops; other site
1407053006539	ABC-ATPase subunit interface; other site
1407053006540	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1407053006541	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1407053006542	dimer interface [polypeptide binding]; other site
1407053006543	conserved gate region; other site
1407053006544	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1407053006545	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1407053006546	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1407053006547	Walker A/P-loop; other site
1407053006548	ATP binding site [chemical binding]; other site
1407053006549	Q-loop/lid; other site
1407053006550	ABC transporter signature motif; other site
1407053006551	Walker B; other site
1407053006552	D-loop; other site
1407053006553	H-loop/switch region; other site
1407053006554	TOBE domain; Region: TOBE_2; pfam08402
1407053006555	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1407053006556	Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643
1407053006557	active site
1407053006558	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
1407053006559	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1407053006560	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
1407053006561	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1407053006562	PYR/PP interface [polypeptide binding]; other site
1407053006563	dimer interface [polypeptide binding]; other site
1407053006564	TPP binding site [chemical binding]; other site
1407053006565	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1407053006566	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1407053006567	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1407053006568	substrate binding site [chemical binding]; other site
1407053006569	ATP binding site [chemical binding]; other site
1407053006570	Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863
1407053006571	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1407053006572	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1407053006573	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1407053006574	putative active site [active]
1407053006575	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1407053006576	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1407053006577	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1407053006578	Protein of unknown function (DUF1612); Region: DUF1612; pfam07756
1407053006579	HTH DNA binding domain; Region: HTH_13; pfam11972
1407053006580	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
1407053006581	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1407053006582	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
1407053006583	dimerization interface [polypeptide binding]; other site
1407053006584	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1407053006585	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1407053006586	dimer interface [polypeptide binding]; other site
1407053006587	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1407053006588	catalytic triad [active]
1407053006589	peroxidatic and resolving cysteines [active]
1407053006590	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
1407053006591	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1407053006592	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1407053006593	metabolite-proton symporter; Region: 2A0106; TIGR00883
1407053006594	putative substrate translocation pore; other site
1407053006595	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1407053006596	Multicopper oxidase; Region: Cu-oxidase; pfam00394
1407053006597	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
1407053006598	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
1407053006599	E-class dimer interface [polypeptide binding]; other site
1407053006600	P-class dimer interface [polypeptide binding]; other site
1407053006601	active site
1407053006602	Cu2+ binding site [ion binding]; other site
1407053006603	Zn2+ binding site [ion binding]; other site
1407053006604	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1407053006605	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1407053006606	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1407053006607	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
1407053006608	Walker A/P-loop; other site
1407053006609	ATP binding site [chemical binding]; other site
1407053006610	Q-loop/lid; other site
1407053006611	ABC transporter signature motif; other site
1407053006612	Walker B; other site
1407053006613	D-loop; other site
1407053006614	H-loop/switch region; other site
1407053006615	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1407053006616	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1407053006617	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1407053006618	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053006619	dimer interface [polypeptide binding]; other site
1407053006620	conserved gate region; other site
1407053006621	putative PBP binding loops; other site
1407053006622	ABC-ATPase subunit interface; other site
1407053006623	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053006624	dimer interface [polypeptide binding]; other site
1407053006625	conserved gate region; other site
1407053006626	putative PBP binding loops; other site
1407053006627	ABC-ATPase subunit interface; other site
1407053006628	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
1407053006629	lumazine synthase and riboflavin synthase; involved in the riboflavin (vitamin B2) biosynthetic pathway; Region: Lumazine_synthase-like; cl00317
1407053006630	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109
1407053006631	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1407053006632	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053006633	dimer interface [polypeptide binding]; other site
1407053006634	conserved gate region; other site
1407053006635	putative PBP binding loops; other site
1407053006636	ABC-ATPase subunit interface; other site
1407053006637	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1407053006638	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1407053006639	Walker A/P-loop; other site
1407053006640	ATP binding site [chemical binding]; other site
1407053006641	Q-loop/lid; other site
1407053006642	ABC transporter signature motif; other site
1407053006643	Walker B; other site
1407053006644	D-loop; other site
1407053006645	H-loop/switch region; other site
1407053006646	TOBE domain; Region: TOBE_2; pfam08402
1407053006647	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1407053006648	putative transporter; Provisional; Region: PRK10504
1407053006649	putative substrate translocation pore; other site
1407053006650	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1407053006651	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
1407053006652	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1407053006653	S-adenosylmethionine binding site [chemical binding]; other site
1407053006654	exopolyphosphatase; Region: exo_poly_only; TIGR03706
1407053006655	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1407053006656	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053006657	dimer interface [polypeptide binding]; other site
1407053006658	conserved gate region; other site
1407053006659	putative PBP binding loops; other site
1407053006660	ABC-ATPase subunit interface; other site
1407053006661	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1407053006662	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1407053006663	substrate binding pocket [chemical binding]; other site
1407053006664	membrane-bound complex binding site; other site
1407053006665	hinge residues; other site
1407053006666	5-oxoprolinase; Region: PLN02666
1407053006667	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
1407053006668	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
1407053006669	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
1407053006670	Predicted transcription regulator, contains HTH domain (MarR family) [Transcription]; Region: COG5631
1407053006671	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
1407053006672	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1407053006673	Walker A/P-loop; other site
1407053006674	ATP binding site [chemical binding]; other site
1407053006675	Q-loop/lid; other site
1407053006676	ABC transporter signature motif; other site
1407053006677	Walker B; other site
1407053006678	D-loop; other site
1407053006679	H-loop/switch region; other site
1407053006680	ABC-type enterochelin transport system, permease component [Inorganic ion transport and metabolism]; Region: CeuC; COG4605
1407053006681	ABC-ATPase subunit  interface; other site
1407053006682	dimer interface [polypeptide binding]; other site
1407053006683	putative PBP binding regions; other site
1407053006684	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
1407053006685	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1407053006686	putative ligand binding residues [chemical binding]; other site
1407053006687	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
1407053006688	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1407053006689	NAD binding site [chemical binding]; other site
1407053006690	catalytic residues [active]
1407053006691	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
1407053006692	FAD binding domain; Region: FAD_binding_2; pfam00890
1407053006693	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1407053006694	aminotransferase; Provisional; Region: PRK13356
1407053006695	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1407053006696	homodimer interface [polypeptide binding]; other site
1407053006697	substrate-cofactor binding pocket; other site
1407053006698	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1407053006699	catalytic residue [active]
1407053006700	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1407053006701	EamA-like transporter family; Region: EamA; pfam00892
1407053006702	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1407053006703	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1407053006704	nucleoside/Zn binding site; other site
1407053006705	dimer interface [polypeptide binding]; other site
1407053006706	catalytic motif [active]
1407053006707	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1407053006708	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1407053006709	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1407053006710	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1407053006711	Walker A/P-loop; other site
1407053006712	ATP binding site [chemical binding]; other site
1407053006713	Q-loop/lid; other site
1407053006714	ABC transporter signature motif; other site
1407053006715	Walker B; other site
1407053006716	D-loop; other site
1407053006717	H-loop/switch region; other site
1407053006718	TOBE domain; Region: TOBE_2; pfam08402
1407053006719	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1407053006720	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053006721	dimer interface [polypeptide binding]; other site
1407053006722	conserved gate region; other site
1407053006723	ABC-ATPase subunit interface; other site
1407053006724	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1407053006725	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1407053006726	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
1407053006727	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
1407053006728	active site
1407053006729	dimer interface [polypeptide binding]; other site
1407053006730	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1407053006731	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1407053006732	Walker A/P-loop; other site
1407053006733	ATP binding site [chemical binding]; other site
1407053006734	Q-loop/lid; other site
1407053006735	ABC transporter signature motif; other site
1407053006736	Walker B; other site
1407053006737	D-loop; other site
1407053006738	H-loop/switch region; other site
1407053006739	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1407053006740	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1407053006741	TM-ABC transporter signature motif; other site
1407053006742	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1407053006743	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1407053006744	TM-ABC transporter signature motif; other site
1407053006745	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1407053006746	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1407053006747	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
1407053006748	Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463
1407053006749	heterodimer interface [polypeptide binding]; other site
1407053006750	active site
1407053006751	4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425
1407053006752	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
1407053006753	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
1407053006754	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1407053006755	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1407053006756	dimerization interface [polypeptide binding]; other site
1407053006757	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
1407053006758	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1407053006759	hypothetical protein; Provisional; Region: PRK07236
1407053006760	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
1407053006761	Cupin domain; Region: Cupin_2; cl17218
1407053006762	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1407053006763	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
1407053006764	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1407053006765	Bacterial transcriptional regulator; Region: IclR; pfam01614
1407053006766	3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429
1407053006767	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
1407053006768	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
1407053006769	active site
1407053006770	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
1407053006771	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1407053006772	active site
1407053006773	catalytic site [active]
1407053006774	substrate binding site [chemical binding]; other site
1407053006775	Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013
1407053006776	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1407053006777	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1407053006778	metal binding site [ion binding]; metal-binding site
1407053006779	active site
1407053006780	I-site; other site
1407053006781	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
1407053006782	DNA polymerase IV; Provisional; Region: PRK02794
1407053006783	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1407053006784	active site
1407053006785	DNA binding site [nucleotide binding]
1407053006786	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
1407053006787	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1407053006788	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1407053006789	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1407053006790	active site
1407053006791	phosphorylation site [posttranslational modification]
1407053006792	intermolecular recognition site; other site
1407053006793	dimerization interface [polypeptide binding]; other site
1407053006794	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1407053006795	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1407053006796	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1407053006797	putative substrate translocation pore; other site
1407053006798	hypothetical protein; Provisional; Region: PRK05978
1407053006799	RNB domain; Region: RNB; pfam00773
1407053006800	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
1407053006801	RNA binding site [nucleotide binding]; other site
1407053006802	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
1407053006803	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1407053006804	active site
1407053006805	interdomain interaction site; other site
1407053006806	putative metal-binding site [ion binding]; other site
1407053006807	nucleotide binding site [chemical binding]; other site
1407053006808	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1407053006809	domain I; other site
1407053006810	DNA binding groove [nucleotide binding]
1407053006811	phosphate binding site [ion binding]; other site
1407053006812	domain II; other site
1407053006813	domain III; other site
1407053006814	nucleotide binding site [chemical binding]; other site
1407053006815	catalytic site [active]
1407053006816	domain IV; other site
1407053006817	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1407053006818	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1407053006819	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1407053006820	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1407053006821	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
1407053006822	DNA protecting protein DprA; Region: dprA; TIGR00732
1407053006823	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
1407053006824	dihydroorotase; Validated; Region: PRK09059
1407053006825	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1407053006826	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
1407053006827	active site
1407053006828	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1407053006829	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1407053006830	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1407053006831	Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816
1407053006832	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
1407053006833	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1407053006834	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
1407053006835	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
1407053006836	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1407053006837	Mg2+ binding site [ion binding]; other site
1407053006838	G-X-G motif; other site
1407053006839	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1407053006840	anchoring element; other site
1407053006841	dimer interface [polypeptide binding]; other site
1407053006842	ATP binding site [chemical binding]; other site
1407053006843	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
1407053006844	active site
1407053006845	metal binding site [ion binding]; metal-binding site
1407053006846	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1407053006847	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1407053006848	EamA-like transporter family; Region: EamA; pfam00892
1407053006849	lipoate-protein ligase B; Provisional; Region: PRK14341
1407053006850	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1407053006851	PAS domain; Region: PAS_9; pfam13426
1407053006852	putative active site [active]
1407053006853	heme pocket [chemical binding]; other site
1407053006854	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1407053006855	PAS fold; Region: PAS_3; pfam08447
1407053006856	putative active site [active]
1407053006857	heme pocket [chemical binding]; other site
1407053006858	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1407053006859	HWE histidine kinase; Region: HWE_HK; pfam07536
1407053006860	Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946
1407053006861	Bacterial virulence protein (VirJ); Region: VirJ; pfam06057
1407053006862	Predicted integral membrane protein [Function unknown]; Region: COG0392
1407053006863	Uncharacterized conserved protein [Function unknown]; Region: COG2898
1407053006864	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
1407053006865	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1407053006866	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
1407053006867	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353
1407053006868	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1407053006869	Substrate binding site; other site
1407053006870	Mg++ binding site; other site
1407053006871	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1407053006872	active site
1407053006873	substrate binding site [chemical binding]; other site
1407053006874	CoA binding site [chemical binding]; other site
1407053006875	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1407053006876	Glutamine amidotransferases class-II; Region: GATase_2; pfam00310
1407053006877	glutaminase active site [active]
1407053006878	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1407053006879	dimer interface [polypeptide binding]; other site
1407053006880	active site
1407053006881	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1407053006882	generic binding surface II; other site
1407053006883	ssDNA binding site; other site
1407053006884	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1407053006885	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1407053006886	ATP binding site [chemical binding]; other site
1407053006887	putative Mg++ binding site [ion binding]; other site
1407053006888	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1407053006889	nucleotide binding region [chemical binding]; other site
1407053006890	ATP-binding site [chemical binding]; other site
1407053006891	Uncharacterized conserved protein [Function unknown]; Region: COG2938
1407053006892	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
1407053006893	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
1407053006894	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1407053006895	ATP binding site [chemical binding]; other site
1407053006896	putative Mg++ binding site [ion binding]; other site
1407053006897	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1407053006898	nucleotide binding region [chemical binding]; other site
1407053006899	ATP-binding site [chemical binding]; other site
1407053006900	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
1407053006901	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1407053006902	fosfomycin resistance protein FosB; Provisional; Region: PRK04101
1407053006903	active site
1407053006904	metal binding site [ion binding]; metal-binding site
1407053006905	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
1407053006906	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
1407053006907	catalytic residues [active]
1407053006908	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1407053006909	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
1407053006910	Hemimethylated DNA-binding protein YccV like; Region: YccV-like; cl01548
1407053006911	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
1407053006912	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
1407053006913	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
1407053006914	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
1407053006915	NADP binding site [chemical binding]; other site
1407053006916	dimer interface [polypeptide binding]; other site
1407053006917	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
1407053006918	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1407053006919	Walker A/P-loop; other site
1407053006920	ATP binding site [chemical binding]; other site
1407053006921	Q-loop/lid; other site
1407053006922	ABC transporter signature motif; other site
1407053006923	Walker B; other site
1407053006924	D-loop; other site
1407053006925	H-loop/switch region; other site
1407053006926	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1407053006927	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1407053006928	TM-ABC transporter signature motif; other site
1407053006929	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
1407053006930	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
1407053006931	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
1407053006932	putative ligand binding site [chemical binding]; other site
1407053006933	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
1407053006934	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1407053006935	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1407053006936	FeS/SAM binding site; other site
1407053006937	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
1407053006938	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
1407053006939	heme binding site [chemical binding]; other site
1407053006940	ferroxidase pore; other site
1407053006941	ferroxidase diiron center [ion binding]; other site
1407053006942	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1407053006943	iron-responsive transcriptional regulator; Reviewed; Region: rirA; PRK11920
1407053006944	Predicted transcriptional regulator [Transcription]; Region: COG1959
1407053006945	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
1407053006946	putative deacylase active site [active]
1407053006947	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1407053006948	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1407053006949	Transposase; Region: HTH_Tnp_1; pfam01527
1407053006950	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1407053006951	Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173
1407053006952	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1407053006953	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1407053006954	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1407053006955	Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124
1407053006956	Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124
1407053006957	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
1407053006958	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1407053006959	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1407053006960	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1407053006961	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
1407053006962	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1407053006963	active site
1407053006964	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
1407053006965	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1407053006966	NAD binding site [chemical binding]; other site
1407053006967	homodimer interface [polypeptide binding]; other site
1407053006968	active site
1407053006969	substrate binding site [chemical binding]; other site
1407053006970	Predicted integral membrane protein [Function unknown]; Region: COG5455
1407053006971	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1407053006972	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1407053006973	peptide binding site [polypeptide binding]; other site
1407053006974	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1407053006975	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1407053006976	peptide binding site [polypeptide binding]; other site
1407053006977	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
1407053006978	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053006979	dimer interface [polypeptide binding]; other site
1407053006980	conserved gate region; other site
1407053006981	putative PBP binding loops; other site
1407053006982	ABC-ATPase subunit interface; other site
1407053006983	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053006984	dimer interface [polypeptide binding]; other site
1407053006985	conserved gate region; other site
1407053006986	ABC-ATPase subunit interface; other site
1407053006987	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
1407053006988	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1407053006989	Walker A/P-loop; other site
1407053006990	ATP binding site [chemical binding]; other site
1407053006991	Q-loop/lid; other site
1407053006992	ABC transporter signature motif; other site
1407053006993	Walker B; other site
1407053006994	D-loop; other site
1407053006995	H-loop/switch region; other site
1407053006996	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1407053006997	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1407053006998	Walker A/P-loop; other site
1407053006999	ATP binding site [chemical binding]; other site
1407053007000	Q-loop/lid; other site
1407053007001	ABC transporter signature motif; other site
1407053007002	Walker B; other site
1407053007003	D-loop; other site
1407053007004	H-loop/switch region; other site
1407053007005	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1407053007006	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
1407053007007	benzoate transport; Region: 2A0115; TIGR00895
1407053007008	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1407053007009	putative substrate translocation pore; other site
1407053007010	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1407053007011	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1407053007012	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1407053007013	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
1407053007014	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1407053007015	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1407053007016	alpha subunit interface [polypeptide binding]; other site
1407053007017	TPP binding site [chemical binding]; other site
1407053007018	heterodimer interface [polypeptide binding]; other site
1407053007019	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1407053007020	2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573
1407053007021	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
1407053007022	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1407053007023	tetramer interface [polypeptide binding]; other site
1407053007024	TPP-binding site [chemical binding]; other site
1407053007025	heterodimer interface [polypeptide binding]; other site
1407053007026	phosphorylation loop region [posttranslational modification]
1407053007027	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1407053007028	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1407053007029	Walker A/P-loop; other site
1407053007030	ATP binding site [chemical binding]; other site
1407053007031	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1407053007032	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1407053007033	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1407053007034	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1407053007035	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1407053007036	nucleotide binding site [chemical binding]; other site
1407053007037	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1407053007038	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1407053007039	DNA-binding site [nucleotide binding]; DNA binding site
1407053007040	UTRA domain; Region: UTRA; pfam07702
1407053007041	Predicted outer membrane lipoprotein [Function unknown]; Region: COG4890
1407053007042	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1407053007043	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1407053007044	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1407053007045	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
1407053007046	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
1407053007047	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1407053007048	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1407053007049	Walker A/P-loop; other site
1407053007050	ATP binding site [chemical binding]; other site
1407053007051	Q-loop/lid; other site
1407053007052	ABC transporter signature motif; other site
1407053007053	Walker B; other site
1407053007054	D-loop; other site
1407053007055	H-loop/switch region; other site
1407053007056	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12671
1407053007057	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161
1407053007058	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12596
1407053007059	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
1407053007060	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1407053007061	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094
1407053007062	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
1407053007063	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
1407053007064	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
1407053007065	dimer interface [polypeptide binding]; other site
1407053007066	FMN binding site [chemical binding]; other site
1407053007067	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1407053007068	MPT binding site; other site
1407053007069	trimer interface [polypeptide binding]; other site
1407053007070	biotin synthase; Region: bioB; TIGR00433
1407053007071	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1407053007072	FeS/SAM binding site; other site
1407053007073	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
1407053007074	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
1407053007075	hypothetical protein; Provisional; Region: PRK07505
1407053007076	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1407053007077	catalytic residue [active]
1407053007078	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
1407053007079	AAA domain; Region: AAA_26; pfam13500
1407053007080	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
1407053007081	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1407053007082	inhibitor-cofactor binding pocket; inhibition site
1407053007083	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1407053007084	catalytic residue [active]
1407053007085	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05963
1407053007086	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1407053007087	dimer interface [polypeptide binding]; other site
1407053007088	active site
1407053007089	CoA binding pocket [chemical binding]; other site
1407053007090	Homoserine trans-succinylase [Amino acid transport and metabolism]; Region: MetA; COG1897
1407053007091	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
1407053007092	proposed active site lysine [active]
1407053007093	conserved cys residue [active]
1407053007094	Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757
1407053007095	Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413
1407053007096	active site
1407053007097	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1407053007098	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1407053007099	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1407053007100	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1407053007101	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1407053007102	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1407053007103	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1407053007104	Uncharacterized conserved protein [Function unknown]; Region: COG3189
1407053007105	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1407053007106	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1407053007107	active site
1407053007108	phosphorylation site [posttranslational modification]
1407053007109	intermolecular recognition site; other site
1407053007110	dimerization interface [polypeptide binding]; other site
1407053007111	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1407053007112	DNA binding site [nucleotide binding]
1407053007113	HAMP domain; Region: HAMP; pfam00672
1407053007114	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1407053007115	dimer interface [polypeptide binding]; other site
1407053007116	phosphorylation site [posttranslational modification]
1407053007117	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1407053007118	ATP binding site [chemical binding]; other site
1407053007119	Mg2+ binding site [ion binding]; other site
1407053007120	G-X-G motif; other site
1407053007121	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
1407053007122	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1407053007123	HlyD family secretion protein; Region: HlyD_3; pfam13437
1407053007124	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1407053007125	putative substrate translocation pore; other site
1407053007126	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1407053007127	MarR family; Region: MarR_2; pfam12802
1407053007128	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1407053007129	H-loop/switch region; other site
1407053007130	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1407053007131	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053007132	dimer interface [polypeptide binding]; other site
1407053007133	conserved gate region; other site
1407053007134	putative PBP binding loops; other site
1407053007135	ABC-ATPase subunit interface; other site
1407053007136	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
1407053007137	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1407053007138	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1407053007139	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552
1407053007140	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1407053007141	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
1407053007142	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1407053007143	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1407053007144	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1407053007145	FCD domain; Region: FCD; pfam07729
1407053007146	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
1407053007147	Predicted transporter component [General function prediction only]; Region: COG2391
1407053007148	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1407053007149	dimerization interface [polypeptide binding]; other site
1407053007150	putative DNA binding site [nucleotide binding]; other site
1407053007151	putative Zn2+ binding site [ion binding]; other site
1407053007152	Protein of unknown function (DUF808); Region: DUF808; cl01002
1407053007153	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1407053007154	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
1407053007155	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1407053007156	acyl-activating enzyme (AAE) consensus motif; other site
1407053007157	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
1407053007158	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
1407053007159	NAD binding site [chemical binding]; other site
1407053007160	homodimer interface [polypeptide binding]; other site
1407053007161	homotetramer interface [polypeptide binding]; other site
1407053007162	active site
1407053007163	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
1407053007164	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1407053007165	dimer interface [polypeptide binding]; other site
1407053007166	active site
1407053007167	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
1407053007168	putative dimerization interface [polypeptide binding]; other site
1407053007169	putative substrate binding pocket [chemical binding]; other site
1407053007170	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
1407053007171	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
1407053007172	N- and C-terminal domain interface [polypeptide binding]; other site
1407053007173	active site
1407053007174	MgATP binding site [chemical binding]; other site
1407053007175	catalytic site [active]
1407053007176	metal binding site [ion binding]; metal-binding site
1407053007177	glycerol binding site [chemical binding]; other site
1407053007178	homotetramer interface [polypeptide binding]; other site
1407053007179	homodimer interface [polypeptide binding]; other site
1407053007180	FBP binding site [chemical binding]; other site
1407053007181	protein IIAGlc interface [polypeptide binding]; other site
1407053007182	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
1407053007183	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
1407053007184	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1407053007185	active site
1407053007186	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
1407053007187	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1407053007188	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1407053007189	S-adenosylmethionine binding site [chemical binding]; other site
1407053007190	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
1407053007191	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
1407053007192	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1407053007193	extended (e) SDRs; Region: SDR_e; cd08946
1407053007194	NAD(P) binding site [chemical binding]; other site
1407053007195	active site
1407053007196	substrate binding site [chemical binding]; other site
1407053007197	Protein of unknown function (DUF4038); Region: DUF4038; pfam13204
1407053007198	glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209
1407053007199	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1407053007200	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1407053007201	catalytic residue [active]
1407053007202	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1407053007203	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1407053007204	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
1407053007205	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
1407053007206	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
1407053007207	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
1407053007208	Mg++ binding site [ion binding]; other site
1407053007209	putative catalytic motif [active]
1407053007210	substrate binding site [chemical binding]; other site
1407053007211	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1407053007212	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
1407053007213	putative metal binding site; other site
1407053007214	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1407053007215	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1407053007216	putative active site [active]
1407053007217	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
1407053007218	putative trimer interface [polypeptide binding]; other site
1407053007219	putative active site [active]
1407053007220	putative substrate binding site [chemical binding]; other site
1407053007221	putative CoA binding site [chemical binding]; other site
1407053007222	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
1407053007223	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1407053007224	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1407053007225	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1407053007226	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
1407053007227	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
1407053007228	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
1407053007229	NADP-binding site; other site
1407053007230	homotetramer interface [polypeptide binding]; other site
1407053007231	substrate binding site [chemical binding]; other site
1407053007232	homodimer interface [polypeptide binding]; other site
1407053007233	active site
1407053007234	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
1407053007235	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
1407053007236	NADP binding site [chemical binding]; other site
1407053007237	active site
1407053007238	putative substrate binding site [chemical binding]; other site
1407053007239	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
1407053007240	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
1407053007241	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
1407053007242	Chain length determinant protein; Region: Wzz; cl15801
1407053007243	AAA domain; Region: AAA_31; pfam13614
1407053007244	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1407053007245	G3 box; other site
1407053007246	Switch II region; other site
1407053007247	G4 box; other site
1407053007248	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1407053007249	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1407053007250	DNA binding residues [nucleotide binding]
1407053007251	dimerization interface [polypeptide binding]; other site
1407053007252	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1407053007253	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1407053007254	ligand binding site [chemical binding]; other site
1407053007255	flexible hinge region; other site
1407053007256	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1407053007257	putative switch regulator; other site
1407053007258	non-specific DNA interactions [nucleotide binding]; other site
1407053007259	DNA binding site [nucleotide binding]
1407053007260	sequence specific DNA binding site [nucleotide binding]; other site
1407053007261	putative cAMP binding site [chemical binding]; other site
1407053007262	N-acetylmannosamine kinase; Provisional; Region: PRK05082
1407053007263	Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010
1407053007264	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
1407053007265	putative active site cavity [active]
1407053007266	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1407053007267	nucleotide binding site [chemical binding]; other site
1407053007268	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1407053007269	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1407053007270	DNA-binding site [nucleotide binding]; DNA binding site
1407053007271	FCD domain; Region: FCD; pfam07729
1407053007272	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
1407053007273	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1407053007274	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1407053007275	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053007276	dimer interface [polypeptide binding]; other site
1407053007277	conserved gate region; other site
1407053007278	putative PBP binding loops; other site
1407053007279	ABC-ATPase subunit interface; other site
1407053007280	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1407053007281	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053007282	dimer interface [polypeptide binding]; other site
1407053007283	conserved gate region; other site
1407053007284	putative PBP binding loops; other site
1407053007285	ABC-ATPase subunit interface; other site
1407053007286	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1407053007287	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1407053007288	inhibitor site; inhibition site
1407053007289	active site
1407053007290	dimer interface [polypeptide binding]; other site
1407053007291	catalytic residue [active]
1407053007292	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1407053007293	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1407053007294	Walker A/P-loop; other site
1407053007295	ATP binding site [chemical binding]; other site
1407053007296	Q-loop/lid; other site
1407053007297	ABC transporter signature motif; other site
1407053007298	Walker B; other site
1407053007299	D-loop; other site
1407053007300	H-loop/switch region; other site
1407053007301	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1407053007302	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
1407053007303	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1407053007304	Walker A/P-loop; other site
1407053007305	ATP binding site [chemical binding]; other site
1407053007306	Q-loop/lid; other site
1407053007307	ABC transporter signature motif; other site
1407053007308	Walker B; other site
1407053007309	D-loop; other site
1407053007310	H-loop/switch region; other site
1407053007311	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1407053007312	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1407053007313	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1407053007314	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
1407053007315	Zinc-dependent alcohol dehydrogenases (ADH) and class III ADG (AKA formaldehyde dehydrogenase); Region: liver_ADH_like1; cd08281
1407053007316	NAD binding site [chemical binding]; other site
1407053007317	catalytic Zn binding site [ion binding]; other site
1407053007318	substrate binding site [chemical binding]; other site
1407053007319	structural Zn binding site [ion binding]; other site
1407053007320	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1407053007321	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1407053007322	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1407053007323	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1407053007324	tetramerization interface [polypeptide binding]; other site
1407053007325	NAD(P) binding site [chemical binding]; other site
1407053007326	catalytic residues [active]
1407053007327	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341
1407053007328	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
1407053007329	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
1407053007330	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1407053007331	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1407053007332	shikimate binding site; other site
1407053007333	NAD(P) binding site [chemical binding]; other site
1407053007334	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1407053007335	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1407053007336	NAD(P) binding site [chemical binding]; other site
1407053007337	active site
1407053007338	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1407053007339	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1407053007340	Walker A/P-loop; other site
1407053007341	ATP binding site [chemical binding]; other site
1407053007342	Q-loop/lid; other site
1407053007343	ABC transporter signature motif; other site
1407053007344	Walker B; other site
1407053007345	D-loop; other site
1407053007346	H-loop/switch region; other site
1407053007347	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1407053007348	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1407053007349	TM-ABC transporter signature motif; other site
1407053007350	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1407053007351	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1407053007352	Walker A/P-loop; other site
1407053007353	ATP binding site [chemical binding]; other site
1407053007354	Q-loop/lid; other site
1407053007355	ABC transporter signature motif; other site
1407053007356	Walker B; other site
1407053007357	D-loop; other site
1407053007358	H-loop/switch region; other site
1407053007359	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1407053007360	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1407053007361	TM-ABC transporter signature motif; other site
1407053007362	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1407053007363	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1407053007364	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
1407053007365	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
1407053007366	NAD(P) binding site [chemical binding]; other site
1407053007367	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1407053007368	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1407053007369	DNA-binding site [nucleotide binding]; DNA binding site
1407053007370	FCD domain; Region: FCD; pfam07729
1407053007371	putative phosphoketolase; Provisional; Region: PRK05261
1407053007372	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
1407053007373	TPP-binding site; other site
1407053007374	XFP C-terminal domain; Region: XFP_C; pfam09363
1407053007375	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
1407053007376	GMP synthase; Reviewed; Region: guaA; PRK00074
1407053007377	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1407053007378	AMP/PPi binding site [chemical binding]; other site
1407053007379	candidate oxyanion hole; other site
1407053007380	catalytic triad [active]
1407053007381	potential glutamine specificity residues [chemical binding]; other site
1407053007382	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1407053007383	ATP Binding subdomain [chemical binding]; other site
1407053007384	Ligand Binding sites [chemical binding]; other site
1407053007385	Dimerization subdomain; other site
1407053007386	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06026
1407053007387	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, putative; Region: MTA/SAH-nuc-hyp; TIGR01705
1407053007388	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1407053007389	CoenzymeA binding site [chemical binding]; other site
1407053007390	subunit interaction site [polypeptide binding]; other site
1407053007391	PHB binding site; other site
1407053007392	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
1407053007393	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
1407053007394	Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495
1407053007395	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
1407053007396	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
1407053007397	tetramer interface [polypeptide binding]; other site
1407053007398	heme binding pocket [chemical binding]; other site
1407053007399	NADPH binding site [chemical binding]; other site
1407053007400	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1407053007401	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
1407053007402	dimerization interface [polypeptide binding]; other site
1407053007403	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1407053007404	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1407053007405	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1407053007406	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1407053007407	active site
1407053007408	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1407053007409	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
1407053007410	putative ion selectivity filter; other site
1407053007411	putative pore gating glutamate residue; other site
1407053007412	putative H+/Cl- coupling transport residue; other site
1407053007413	DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603
1407053007414	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
1407053007415	ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088
1407053007416	active site
1407053007417	substrate binding site [chemical binding]; other site
1407053007418	metal binding site [ion binding]; metal-binding site
1407053007419	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
1407053007420	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
1407053007421	Substrate binding site; other site
1407053007422	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
1407053007423	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1407053007424	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1407053007425	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1407053007426	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
1407053007427	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
1407053007428	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1407053007429	acid-resistance protein; Provisional; Region: PRK10208
1407053007430	glutaminase; Reviewed; Region: PRK12356
1407053007431	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
1407053007432	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
1407053007433	tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812
1407053007434	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1407053007435	catalytic residue [active]
1407053007436	Predicted membrane protein [Function unknown]; Region: COG4803
1407053007437	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1407053007438	HlyD family secretion protein; Region: HlyD_3; pfam13437
1407053007439	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1407053007440	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
1407053007441	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1407053007442	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053007443	dimer interface [polypeptide binding]; other site
1407053007444	conserved gate region; other site
1407053007445	putative PBP binding loops; other site
1407053007446	ABC-ATPase subunit interface; other site
1407053007447	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053007448	dimer interface [polypeptide binding]; other site
1407053007449	conserved gate region; other site
1407053007450	putative PBP binding loops; other site
1407053007451	ABC-ATPase subunit interface; other site
1407053007452	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1407053007453	Walker A/P-loop; other site
1407053007454	ATP binding site [chemical binding]; other site
1407053007455	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
1407053007456	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
1407053007457	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
1407053007458	Switch I; other site
1407053007459	Switch II; other site
1407053007460	septum formation inhibitor; Reviewed; Region: minC; PRK05177
1407053007461	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
1407053007462	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
1407053007463	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1407053007464	dimer interface [polypeptide binding]; other site
1407053007465	putative radical transfer pathway; other site
1407053007466	diiron center [ion binding]; other site
1407053007467	tyrosyl radical; other site
1407053007468	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
1407053007469	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
1407053007470	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1407053007471	active site
1407053007472	dimer interface [polypeptide binding]; other site
1407053007473	catalytic residues [active]
1407053007474	effector binding site; other site
1407053007475	R2 peptide binding site; other site
1407053007476	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
1407053007477	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
1407053007478	catalytic residues [active]
1407053007479	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1407053007480	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1407053007481	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1407053007482	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1407053007483	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1407053007484	Walker A/P-loop; other site
1407053007485	ATP binding site [chemical binding]; other site
1407053007486	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1407053007487	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1407053007488	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053007489	dimer interface [polypeptide binding]; other site
1407053007490	conserved gate region; other site
1407053007491	putative PBP binding loops; other site
1407053007492	ABC-ATPase subunit interface; other site
1407053007493	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1407053007494	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1407053007495	DNA binding site [nucleotide binding]
1407053007496	domain linker motif; other site
1407053007497	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
1407053007498	ligand binding site [chemical binding]; other site
1407053007499	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1407053007500	ligand binding site [chemical binding]; other site
1407053007501	flexible hinge region; other site
1407053007502	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
1407053007503	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
1407053007504	[4Fe-4S] binding site [ion binding]; other site
1407053007505	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1407053007506	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1407053007507	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1407053007508	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
1407053007509	molybdopterin cofactor binding site; other site
1407053007510	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
1407053007511	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
1407053007512	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
1407053007513	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
1407053007514	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959
1407053007515	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
1407053007516	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1407053007517	Protein of unknown function (DUF2478); Region: DUF2478; pfam10649
1407053007518	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
1407053007519	Flavoprotein; Region: Flavoprotein; pfam02441
1407053007520	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
1407053007521	Putative lipid carrier protein [Lipid metabolism]; Region: COG3154
1407053007522	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1407053007523	Peptidase family U32; Region: Peptidase_U32; pfam01136
1407053007524	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1407053007525	putative protease; Provisional; Region: PRK15447
1407053007526	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1407053007527	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1407053007528	Walker A/P-loop; other site
1407053007529	ATP binding site [chemical binding]; other site
1407053007530	Q-loop/lid; other site
1407053007531	ABC transporter signature motif; other site
1407053007532	Walker B; other site
1407053007533	D-loop; other site
1407053007534	H-loop/switch region; other site
1407053007535	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1407053007536	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1407053007537	dimer interface [polypeptide binding]; other site
1407053007538	conserved gate region; other site
1407053007539	putative PBP binding loops; other site
1407053007540	ABC-ATPase subunit interface; other site
1407053007541	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1407053007542	NMT1-like family; Region: NMT1_2; pfam13379
1407053007543	Uncharacterized protein involved in response to NO [Inorganic ion transport and metabolism]; Region: NnrS; COG3213
1407053007544	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
1407053007545	pseudoazurin; Region: pseudoazurin; TIGR02375
1407053007546	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1407053007547	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1407053007548	ligand binding site [chemical binding]; other site
1407053007549	flexible hinge region; other site
1407053007550	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1407053007551	putative switch regulator; other site
1407053007552	non-specific DNA interactions [nucleotide binding]; other site
1407053007553	DNA binding site [nucleotide binding]
1407053007554	sequence specific DNA binding site [nucleotide binding]; other site
1407053007555	putative cAMP binding site [chemical binding]; other site
1407053007556	Predicted lipoprotein involved in nitrous oxide reduction [Energy production and conversion]; Region: NosL; COG4314
1407053007557	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
1407053007558	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1407053007559	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1407053007560	Walker A/P-loop; other site
1407053007561	ATP binding site [chemical binding]; other site
1407053007562	Q-loop/lid; other site
1407053007563	ABC transporter signature motif; other site
1407053007564	Walker B; other site
1407053007565	D-loop; other site
1407053007566	H-loop/switch region; other site
1407053007567	Domain present in carbohydrate binding proteins and sugar hydrolses; Region: CASH; smart00722
1407053007568	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
1407053007569	Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048
1407053007570	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1407053007571	Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901
1407053007572	4Fe-4S binding domain; Region: Fer4_5; pfam12801
1407053007573	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
1407053007574	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
1407053007575	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
1407053007576	RES domain; Region: RES; smart00953
1407053007577	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1407053007578	classical (c) SDRs; Region: SDR_c; cd05233
1407053007579	NAD(P) binding site [chemical binding]; other site
1407053007580	active site
1407053007581	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1407053007582	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1407053007583	TM-ABC transporter signature motif; other site
1407053007584	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1407053007585	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1407053007586	Walker A/P-loop; other site
1407053007587	ATP binding site [chemical binding]; other site
1407053007588	Q-loop/lid; other site
1407053007589	ABC transporter signature motif; other site
1407053007590	Walker B; other site
1407053007591	D-loop; other site
1407053007592	H-loop/switch region; other site
1407053007593	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
1407053007594	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
1407053007595	putative ligand binding site [chemical binding]; other site
1407053007596	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1407053007597	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1407053007598	DNA binding site [nucleotide binding]
1407053007599	domain linker motif; other site
1407053007600	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1407053007601	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1407053007602	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1407053007603	ligand binding site [chemical binding]; other site
1407053007604	flexible hinge region; other site
1407053007605	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1407053007606	putative switch regulator; other site
1407053007607	non-specific DNA interactions [nucleotide binding]; other site
1407053007608	DNA binding site [nucleotide binding]
1407053007609	sequence specific DNA binding site [nucleotide binding]; other site
1407053007610	putative cAMP binding site [chemical binding]; other site
1407053007611	Uncharacterized conserved protein [Function unknown]; Region: COG1262
1407053007612	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1407053007613	nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376
1407053007614	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1407053007615	Multicopper oxidase; Region: Cu-oxidase; pfam00394
1407053007616	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
1407053007617	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
1407053007618	nucleophilic elbow; other site
1407053007619	catalytic triad; other site
1407053007620	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
1407053007621	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1407053007622	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
1407053007623	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
1407053007624	metal ion-dependent adhesion site (MIDAS); other site
1407053007625	MoxR-like ATPases [General function prediction only]; Region: COG0714
1407053007626	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1407053007627	Walker A motif; other site
1407053007628	ATP binding site [chemical binding]; other site
1407053007629	Walker B motif; other site
1407053007630	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
1407053007631	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
1407053007632	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
1407053007633	Binuclear center (active site) [active]
1407053007634	K-pathway; other site
1407053007635	Putative proton exit pathway; other site
1407053007636	Cytochrome c; Region: Cytochrom_C; pfam00034
1407053007637	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
1407053007638	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
1407053007639	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1407053007640	Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440
1407053007641	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
1407053007642	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1407053007643	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1407053007644	inhibitor site; inhibition site
1407053007645	active site
1407053007646	dimer interface [polypeptide binding]; other site
1407053007647	catalytic residue [active]
1407053007648	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1407053007649	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1407053007650	DNA-binding site [nucleotide binding]; DNA binding site
1407053007651	FCD domain; Region: FCD; pfam07729
1407053007652	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1407053007653	EamA-like transporter family; Region: EamA; pfam00892
1407053007654	EamA-like transporter family; Region: EamA; cl17759
1407053007655	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1407053007656	GAF domain; Region: GAF; pfam01590
1407053007657	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1407053007658	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1407053007659	metal binding site [ion binding]; metal-binding site
1407053007660	active site
1407053007661	I-site; other site
1407053007662	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
1407053007663	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
1407053007664	Flavodoxin; Region: Flavodoxin_1; pfam00258
1407053007665	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide.  Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like2; cd06201
1407053007666	FAD binding pocket [chemical binding]; other site
1407053007667	FAD binding motif [chemical binding]; other site
1407053007668	catalytic residues [active]
1407053007669	NAD binding pocket [chemical binding]; other site
1407053007670	phosphate binding motif [ion binding]; other site
1407053007671	beta-alpha-beta structure motif; other site
1407053007672	Uncharacterized conserved protein [Function unknown]; Region: COG5591
1407053007673	HAMP domain; Region: HAMP; pfam00672
1407053007674	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1407053007675	dimer interface [polypeptide binding]; other site
1407053007676	phosphorylation site [posttranslational modification]
1407053007677	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1407053007678	Mg2+ binding site [ion binding]; other site
1407053007679	G-X-G motif; other site
1407053007680	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
1407053007681	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
1407053007682	potential catalytic triad [active]
1407053007683	conserved cys residue [active]
1407053007684	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg7; cd04786
1407053007685	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1407053007686	DNA binding residues [nucleotide binding]
1407053007687	putative dimer interface [polypeptide binding]; other site
1407053007688	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1407053007689	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1407053007690	3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268
1407053007691	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1407053007692	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1407053007693	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1407053007694	enoyl-CoA hydratase; Provisional; Region: PRK08138
1407053007695	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1407053007696	substrate binding site [chemical binding]; other site
1407053007697	oxyanion hole (OAH) forming residues; other site
1407053007698	trimer interface [polypeptide binding]; other site
1407053007699	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1407053007700	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1407053007701	Bacterial transcriptional regulator; Region: IclR; pfam01614
1407053007702	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1407053007703	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1407053007704	active site
1407053007705	benzoate transport; Region: 2A0115; TIGR00895
1407053007706	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1407053007707	putative substrate translocation pore; other site
1407053007708	3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519
1407053007709	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
1407053007710	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1407053007711	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
1407053007712	putative acyl-acceptor binding pocket; other site
1407053007713	Domain of unknown function (DUF4170); Region: DUF4170; pfam13773
1407053007714	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1407053007715	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
1407053007716	active site
1407053007717	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
1407053007718	glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659
1407053007719	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1407053007720	TrkA-N domain; Region: TrkA_N; pfam02254
1407053007721	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
1407053007722	pseudouridine synthase; Region: TIGR00093
1407053007723	active site
1407053007724	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
1407053007725	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1407053007726	S-adenosylmethionine binding site [chemical binding]; other site
1407053007727	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1407053007728	nucleoside/Zn binding site; other site
1407053007729	dimer interface [polypeptide binding]; other site
1407053007730	catalytic motif [active]
1407053007731	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1407053007732	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1407053007733	Riboflavin kinase; Region: Flavokinase; smart00904
1407053007734	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
1407053007735	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
1407053007736	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1407053007737	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1407053007738	oligomerisation interface [polypeptide binding]; other site
1407053007739	mobile loop; other site
1407053007740	roof hairpin; other site
1407053007741	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1407053007742	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1407053007743	ring oligomerisation interface [polypeptide binding]; other site
1407053007744	ATP/Mg binding site [chemical binding]; other site
1407053007745	stacking interactions; other site
1407053007746	hinge regions; other site
1407053007747	fumarate hydratase; Reviewed; Region: fumC; PRK00485
1407053007748	Class II fumarases; Region: Fumarase_classII; cd01362
1407053007749	active site
1407053007750	tetramer interface [polypeptide binding]; other site
1407053007751	Predicted membrane protein [Function unknown]; Region: COG2259
1407053007752	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
1407053007753	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1407053007754	putative substrate translocation pore; other site
1407053007755	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295
1407053007756	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1407053007757	motif 1; other site
1407053007758	dimer interface [polypeptide binding]; other site
1407053007759	active site
1407053007760	motif 2; other site
1407053007761	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1407053007762	active site
1407053007763	motif 3; other site
1407053007764	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1407053007765	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
1407053007766	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1407053007767	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1407053007768	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
1407053007769	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1407053007770	Cysteine-rich domain; Region: CCG; pfam02754
1407053007771	Cysteine-rich domain; Region: CCG; pfam02754
1407053007772	FAD binding domain; Region: FAD_binding_4; pfam01565
1407053007773	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
1407053007774	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
1407053007775	FAD binding domain; Region: FAD_binding_4; pfam01565
1407053007776	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1407053007777	transcriptional activator TtdR; Provisional; Region: PRK09801
1407053007778	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1407053007779	putative effector binding pocket; other site
1407053007780	dimerization interface [polypeptide binding]; other site
1407053007781	transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464
1407053007782	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1407053007783	DNA-binding site [nucleotide binding]; DNA binding site
1407053007784	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1407053007785	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841
1407053007786	Cytochrome c2 [Energy production and conversion]; Region: COG3474
1407053007787	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
1407053007788	Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468
1407053007789	Autotransporter beta-domain; Region: Autotransporter; pfam03797
1407053007790	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
1407053007791	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
1407053007792	Uncharacterized conserved protein [Function unknown]; Region: COG3777
1407053007793	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1407053007794	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1407053007795	active site 2 [active]
1407053007796	active site 1 [active]
1407053007797	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1407053007798	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1407053007799	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1407053007800	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1407053007801	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
1407053007802	putative dimerization interface [polypeptide binding]; other site
1407053007803	FliP family; Region: FliP; cl00593
1407053007804	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
1407053007805	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
1407053007806	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
1407053007807	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
1407053007808	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
1407053007809	flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK06005
1407053007810	Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261
1407053007811	flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506
1407053007812	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
1407053007813	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790
1407053007814	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782
1407053007815	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1407053007816	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1407053007817	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003
1407053007818	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1407053007819	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1407053007820	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
1407053007821	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1407053007822	Metal-binding active site; metal-binding site
1407053007823	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1407053007824	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1407053007825	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1407053007826	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1407053007827	Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238
1407053007828	putative NAD(P) binding site [chemical binding]; other site
1407053007829	active site
1407053007830	putative substrate binding site [chemical binding]; other site
1407053007831	putative aldolase; Validated; Region: PRK08130
1407053007832	intersubunit interface [polypeptide binding]; other site
1407053007833	active site
1407053007834	Zn2+ binding site [ion binding]; other site
1407053007835	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1407053007836	D-galactonate transporter; Region: 2A0114; TIGR00893
1407053007837	putative substrate translocation pore; other site
1407053007838	Transposase; Region: HTH_Tnp_1; cl17663
1407053007839	Helix-turn-helix domain; Region: HTH_18; pfam12833
1407053007840	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1407053007841	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
1407053007842	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
1407053007843	uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807
1407053007844	putative active site [active]
1407053007845	YdjC motif; other site
1407053007846	Mg binding site [ion binding]; other site
1407053007847	putative homodimer interface [polypeptide binding]; other site
1407053007848	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1407053007849	Putative Catalytic site; other site
1407053007850	DXD motif; other site
1407053007851	Peptidase family M48; Region: Peptidase_M48; cl12018
1407053007852	GtrA-like protein; Region: GtrA; pfam04138
1407053007853	PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389
1407053007854	active site
1407053007855	flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002
1407053007856	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1407053007857	Walker A motif; other site
1407053007858	ATP binding site [chemical binding]; other site
1407053007859	Walker B motif; other site
1407053007860	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642
1407053007861	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1407053007862	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
1407053007863	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
1407053007864	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
1407053007865	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
1407053007866	flagellar motor protein MotA; Validated; Region: PRK09110
1407053007867	Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868
1407053007868	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
1407053007869	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
1407053007870	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
1407053007871	FliG C-terminal domain; Region: FliG_C; pfam01706
1407053007872	Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377
1407053007873	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
1407053007874	Autoinducer binding domain; Region: Autoind_bind; pfam03472
1407053007875	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1407053007876	DNA binding residues [nucleotide binding]
1407053007877	dimerization interface [polypeptide binding]; other site
1407053007878	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1407053007879	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1407053007880	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
1407053007881	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1407053007882	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1407053007883	HlyD family secretion protein; Region: HlyD_3; pfam13437
1407053007884	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1407053007885	putative substrate translocation pore; other site
1407053007886	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1407053007887	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1407053007888	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1407053007889	Walker A/P-loop; other site
1407053007890	ATP binding site [chemical binding]; other site
1407053007891	Q-loop/lid; other site
1407053007892	ABC transporter signature motif; other site
1407053007893	Walker B; other site
1407053007894	D-loop; other site
1407053007895	H-loop/switch region; other site
1407053007896	TOBE domain; Region: TOBE_2; pfam08402
1407053007897	6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG0362
1407053007898	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1407053007899	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
1407053007900	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1407053007901	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1407053007902	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1407053007903	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1407053007904	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1407053007905	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
1407053007906	active site
1407053007907	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
1407053007908	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
1407053007909	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
1407053007910	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
1407053007911	Chain length determinant protein; Region: Wzz; pfam02706
1407053007912	amidase; Provisional; Region: PRK08310
1407053007913	indole-3-acetamide amidohydrolase; Region: PLN02722
1407053007914	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683
1407053007915	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215