-- dump date 20140619_011110 -- class Genbank::misc_feature -- table misc_feature_note -- id note 941967000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 941967000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 941967000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 941967000004 Walker A motif; other site 941967000005 ATP binding site [chemical binding]; other site 941967000006 Walker B motif; other site 941967000007 arginine finger; other site 941967000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 941967000009 DnaA box-binding interface [nucleotide binding]; other site 941967000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 941967000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 941967000012 putative DNA binding surface [nucleotide binding]; other site 941967000013 dimer interface [polypeptide binding]; other site 941967000014 beta-clamp/clamp loader binding surface; other site 941967000015 beta-clamp/translesion DNA polymerase binding surface; other site 941967000016 recombination protein F; Reviewed; Region: recF; PRK00064 941967000017 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 941967000018 Walker A/P-loop; other site 941967000019 ATP binding site [chemical binding]; other site 941967000020 Q-loop/lid; other site 941967000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941967000022 ABC transporter signature motif; other site 941967000023 Walker B; other site 941967000024 D-loop; other site 941967000025 H-loop/switch region; other site 941967000026 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 941967000027 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 941967000028 ATP binding site [chemical binding]; other site 941967000029 substrate interface [chemical binding]; other site 941967000030 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 941967000031 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 941967000032 putative ligand binding site [chemical binding]; other site 941967000033 NAD binding site [chemical binding]; other site 941967000034 dimerization interface [polypeptide binding]; other site 941967000035 catalytic site [active] 941967000036 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 941967000037 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 941967000038 Walker A/P-loop; other site 941967000039 ATP binding site [chemical binding]; other site 941967000040 Q-loop/lid; other site 941967000041 ABC transporter signature motif; other site 941967000042 Walker B; other site 941967000043 D-loop; other site 941967000044 H-loop/switch region; other site 941967000045 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 941967000046 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 941967000047 Walker A/P-loop; other site 941967000048 ATP binding site [chemical binding]; other site 941967000049 Q-loop/lid; other site 941967000050 ABC transporter signature motif; other site 941967000051 Walker B; other site 941967000052 D-loop; other site 941967000053 H-loop/switch region; other site 941967000054 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 941967000055 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 941967000056 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967000057 dimer interface [polypeptide binding]; other site 941967000058 conserved gate region; other site 941967000059 putative PBP binding loops; other site 941967000060 ABC-ATPase subunit interface; other site 941967000061 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 941967000062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967000063 dimer interface [polypeptide binding]; other site 941967000064 conserved gate region; other site 941967000065 putative PBP binding loops; other site 941967000066 ABC-ATPase subunit interface; other site 941967000067 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 941967000068 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 941967000069 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 941967000070 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 941967000071 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 941967000072 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 941967000073 dimerization interface [polypeptide binding]; other site 941967000074 ligand binding site [chemical binding]; other site 941967000075 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 941967000076 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 941967000077 substrate binding site [chemical binding]; other site 941967000078 oxyanion hole (OAH) forming residues; other site 941967000079 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 941967000080 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 941967000081 active site 941967000082 catalytic residues [active] 941967000083 metal binding site [ion binding]; metal-binding site 941967000084 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 941967000085 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 941967000086 ATP-grasp domain; Region: ATP-grasp_4; cl17255 941967000087 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 941967000088 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 941967000089 carboxyltransferase (CT) interaction site; other site 941967000090 biotinylation site [posttranslational modification]; other site 941967000091 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 941967000092 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 941967000093 isovaleryl-CoA dehydrogenase; Region: PLN02519 941967000094 substrate binding site [chemical binding]; other site 941967000095 FAD binding site [chemical binding]; other site 941967000096 catalytic base [active] 941967000097 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 941967000098 active site 941967000099 CoA binding site [chemical binding]; other site 941967000100 AMP binding site [chemical binding]; other site 941967000101 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 941967000102 acyl-activating enzyme (AAE) consensus motif; other site 941967000103 CHRD domain; Region: CHRD; pfam07452 941967000104 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 941967000105 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4530 941967000106 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 941967000107 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 941967000108 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 941967000109 hinge; other site 941967000110 active site 941967000111 cytidylate kinase; Provisional; Region: cmk; PRK00023 941967000112 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 941967000113 CMP-binding site; other site 941967000114 The sites determining sugar specificity; other site 941967000115 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 941967000116 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 941967000117 RNA binding site [nucleotide binding]; other site 941967000118 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 941967000119 RNA binding site [nucleotide binding]; other site 941967000120 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 941967000121 RNA binding site [nucleotide binding]; other site 941967000122 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 941967000123 RNA binding site [nucleotide binding]; other site 941967000124 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 941967000125 RNA binding site [nucleotide binding]; other site 941967000126 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 941967000127 RNA binding site [nucleotide binding]; other site 941967000128 Predicted membrane protein [Function unknown]; Region: COG2855 941967000129 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 941967000130 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941967000131 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 941967000132 putative dimerization interface [polypeptide binding]; other site 941967000133 lytic murein transglycosylase; Region: MltB_2; TIGR02283 941967000134 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 941967000135 N-acetyl-D-glucosamine binding site [chemical binding]; other site 941967000136 recombination protein RecR; Reviewed; Region: recR; PRK00076 941967000137 RecR protein; Region: RecR; pfam02132 941967000138 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 941967000139 putative active site [active] 941967000140 putative metal-binding site [ion binding]; other site 941967000141 tetramer interface [polypeptide binding]; other site 941967000142 hypothetical protein; Validated; Region: PRK00153 941967000143 DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111 941967000144 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941967000145 Walker A motif; other site 941967000146 ATP binding site [chemical binding]; other site 941967000147 Walker B motif; other site 941967000148 arginine finger; other site 941967000149 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 941967000150 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 941967000151 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 941967000152 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 941967000153 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 941967000154 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 941967000155 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 941967000156 putative NADH binding site [chemical binding]; other site 941967000157 putative active site [active] 941967000158 nudix motif; other site 941967000159 putative metal binding site [ion binding]; other site 941967000160 prephenate dehydratase; Provisional; Region: PRK11899 941967000161 Prephenate dehydratase; Region: PDT; pfam00800 941967000162 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 941967000163 putative L-Phe binding site [chemical binding]; other site 941967000164 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 941967000165 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 941967000166 Ligand binding site; other site 941967000167 oligomer interface; other site 941967000168 Cytochrome c2 [Energy production and conversion]; Region: COG3474 941967000169 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 941967000170 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 941967000171 putative MPT binding site; other site 941967000172 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 941967000173 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 941967000174 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 941967000175 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 941967000176 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 941967000177 D-pathway; other site 941967000178 Putative ubiquinol binding site [chemical binding]; other site 941967000179 Low-spin heme (heme b) binding site [chemical binding]; other site 941967000180 Putative water exit pathway; other site 941967000181 Binuclear center (heme o3/CuB) [ion binding]; other site 941967000182 K-pathway; other site 941967000183 Putative proton exit pathway; other site 941967000184 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 941967000185 Subunit I/III interface [polypeptide binding]; other site 941967000186 Subunit III/IV interface [polypeptide binding]; other site 941967000187 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 941967000188 Bacterial SH3 domain; Region: SH3_3; pfam08239 941967000189 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 941967000190 Surface antigen; Region: Bac_surface_Ag; pfam01103 941967000191 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 941967000192 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 941967000193 Family of unknown function (DUF490); Region: DUF490; pfam04357 941967000194 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 941967000195 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 941967000196 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 941967000197 Copper(I)-binding protein [Inorganic ion transport and metabolism]; Region: COG2847 941967000198 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 941967000199 dimer interface [polypeptide binding]; other site 941967000200 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 941967000201 active site 941967000202 metal binding site [ion binding]; metal-binding site 941967000203 glutathione binding site [chemical binding]; other site 941967000204 Domain of unknown function DUF59; Region: DUF59; pfam01883 941967000205 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 941967000206 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 941967000207 Walker A motif; other site 941967000208 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 941967000209 phosphoglucomutase; Region: PLN02307 941967000210 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 941967000211 substrate binding site [chemical binding]; other site 941967000212 dimer interface [polypeptide binding]; other site 941967000213 active site 941967000214 metal binding site [ion binding]; metal-binding site 941967000215 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941967000216 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941967000217 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 941967000218 putative effector binding pocket; other site 941967000219 putative dimerization interface [polypeptide binding]; other site 941967000220 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 941967000221 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 941967000222 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 941967000223 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 941967000224 active site 941967000225 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 941967000226 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 941967000227 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 941967000228 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 941967000229 N-acetyl-D-glucosamine binding site [chemical binding]; other site 941967000230 catalytic residue [active] 941967000231 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 941967000232 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 941967000233 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 941967000234 putative active site [active] 941967000235 putative PHP Thumb interface [polypeptide binding]; other site 941967000236 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 941967000237 generic binding surface II; other site 941967000238 generic binding surface I; other site 941967000239 DNA Polymerase Y-family; Region: PolY_like; cd03468 941967000240 active site 941967000241 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 941967000242 DNA binding site [nucleotide binding] 941967000243 Uncharacterized conserved protein [Function unknown]; Region: COG4544 941967000244 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 941967000245 Haemagglutinin; Region: HIM; pfam05662 941967000246 Haemagglutinin; Region: HIM; pfam05662 941967000247 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 941967000248 Haemagglutinin; Region: HIM; pfam05662 941967000249 Haemagglutinin; Region: HIM; pfam05662 941967000250 YadA-like C-terminal region; Region: YadA; pfam03895 941967000251 argininosuccinate synthase; Provisional; Region: PRK13820 941967000252 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 941967000253 ANP binding site [chemical binding]; other site 941967000254 Substrate Binding Site II [chemical binding]; other site 941967000255 Substrate Binding Site I [chemical binding]; other site 941967000256 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 941967000257 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 941967000258 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941967000259 FeS/SAM binding site; other site 941967000260 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 941967000261 Uncharacterized conserved protein [Function unknown]; Region: COG3339 941967000262 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 941967000263 aromatic arch; other site 941967000264 DCoH dimer interaction site [polypeptide binding]; other site 941967000265 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 941967000266 DCoH tetramer interaction site [polypeptide binding]; other site 941967000267 substrate binding site [chemical binding]; other site 941967000268 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 941967000269 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 941967000270 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 941967000271 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 941967000272 active site 941967000273 catalytic triad [active] 941967000274 oxyanion hole [active] 941967000275 switch loop; other site 941967000276 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941967000277 H-loop/switch region; other site 941967000278 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 941967000279 FtsX-like permease family; Region: FtsX; pfam02687 941967000280 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 941967000281 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 941967000282 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 941967000283 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941967000284 Coenzyme A binding pocket [chemical binding]; other site 941967000285 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 941967000286 Uncharacterized secreted protein [Function unknown]; Region: COG5429 941967000287 aconitate hydratase; Validated; Region: PRK09277 941967000288 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 941967000289 substrate binding site [chemical binding]; other site 941967000290 ligand binding site [chemical binding]; other site 941967000291 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 941967000292 substrate binding site [chemical binding]; other site 941967000293 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 941967000294 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 941967000295 Walker A/P-loop; other site 941967000296 ATP binding site [chemical binding]; other site 941967000297 Q-loop/lid; other site 941967000298 ABC transporter signature motif; other site 941967000299 Walker B; other site 941967000300 D-loop; other site 941967000301 H-loop/switch region; other site 941967000302 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmB; COG2386 941967000303 heme exporter protein CcmC; Region: ccmC; TIGR01191 941967000304 heme exporter protein CcmD; Region: cytochro_ccmD; TIGR03141 941967000305 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 941967000306 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 941967000307 catalytic residues [active] 941967000308 central insert; other site 941967000309 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 941967000310 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 941967000311 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 941967000312 active site 941967000313 phosphorylation site [posttranslational modification] 941967000314 intermolecular recognition site; other site 941967000315 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 941967000316 AsnC family; Region: AsnC_trans_reg; pfam01037 941967000317 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941967000318 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941967000319 active site 941967000320 metal binding site [ion binding]; metal-binding site 941967000321 Domain of Unknown Function (DUF930); Region: DUF930; pfam06059 941967000322 Uncharacterized conserved protein [Function unknown]; Region: COG1434 941967000323 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 941967000324 putative active site [active] 941967000325 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 941967000326 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 941967000327 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 941967000328 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967000329 dimer interface [polypeptide binding]; other site 941967000330 conserved gate region; other site 941967000331 putative PBP binding loops; other site 941967000332 ABC-ATPase subunit interface; other site 941967000333 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967000334 dimer interface [polypeptide binding]; other site 941967000335 conserved gate region; other site 941967000336 putative PBP binding loops; other site 941967000337 ABC-ATPase subunit interface; other site 941967000338 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 941967000339 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 941967000340 Walker A/P-loop; other site 941967000341 ATP binding site [chemical binding]; other site 941967000342 Q-loop/lid; other site 941967000343 ABC transporter signature motif; other site 941967000344 Walker B; other site 941967000345 D-loop; other site 941967000346 H-loop/switch region; other site 941967000347 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 941967000348 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 941967000349 Putative glucoamylase; Region: Glycoamylase; pfam10091 941967000350 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 941967000351 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 941967000352 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 941967000353 Protein of unknown function, DUF608; Region: DUF608; pfam04685 941967000354 Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488 941967000355 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 941967000356 active site 941967000357 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 941967000358 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941967000359 S-adenosylmethionine binding site [chemical binding]; other site 941967000360 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 941967000361 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 941967000362 putative substrate binding site [chemical binding]; other site 941967000363 putative ATP binding site [chemical binding]; other site 941967000364 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 941967000365 classical (c) SDRs; Region: SDR_c; cd05233 941967000366 NAD(P) binding site [chemical binding]; other site 941967000367 active site 941967000368 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 941967000369 Transglycosylase; Region: Transgly; pfam00912 941967000370 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 941967000371 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 941967000372 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 941967000373 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 941967000374 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 941967000375 catalytic site [active] 941967000376 putative active site [active] 941967000377 putative substrate binding site [chemical binding]; other site 941967000378 hypothetical protein; Validated; Region: PRK09104 941967000379 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 941967000380 metal binding site [ion binding]; metal-binding site 941967000381 putative dimer interface [polypeptide binding]; other site 941967000382 DNA polymerase I; Region: pola; TIGR00593 941967000383 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 941967000384 active site 941967000385 metal binding site 1 [ion binding]; metal-binding site 941967000386 putative 5' ssDNA interaction site; other site 941967000387 metal binding site 3; metal-binding site 941967000388 metal binding site 2 [ion binding]; metal-binding site 941967000389 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 941967000390 putative DNA binding site [nucleotide binding]; other site 941967000391 putative metal binding site [ion binding]; other site 941967000392 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 941967000393 active site 941967000394 catalytic site [active] 941967000395 substrate binding site [chemical binding]; other site 941967000396 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 941967000397 active site 941967000398 DNA binding site [nucleotide binding] 941967000399 catalytic site [active] 941967000400 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 941967000401 DEAD-like helicases superfamily; Region: DEXDc; smart00487 941967000402 ATP binding site [chemical binding]; other site 941967000403 Mg++ binding site [ion binding]; other site 941967000404 motif III; other site 941967000405 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941967000406 nucleotide binding region [chemical binding]; other site 941967000407 ATP-binding site [chemical binding]; other site 941967000408 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 941967000409 RNA binding site [nucleotide binding]; other site 941967000410 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 941967000411 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941967000412 Mg2+ binding site [ion binding]; other site 941967000413 G-X-G motif; other site 941967000414 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 941967000415 anchoring element; other site 941967000416 dimer interface [polypeptide binding]; other site 941967000417 ATP binding site [chemical binding]; other site 941967000418 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 941967000419 active site 941967000420 putative metal-binding site [ion binding]; other site 941967000421 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 941967000422 S-formylglutathione hydrolase; Region: PLN02442 941967000423 S-formylglutathione hydrolase; Region: PLN02442 941967000424 Protein of unknown function (DUF1345); Region: DUF1345; cl01753 941967000425 Protein of unknown function (DUF1345); Region: DUF1345; cl01753 941967000426 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941967000427 Coenzyme A binding pocket [chemical binding]; other site 941967000428 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 941967000429 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 941967000430 substrate binding site [chemical binding]; other site 941967000431 catalytic Zn binding site [ion binding]; other site 941967000432 NAD binding site [chemical binding]; other site 941967000433 structural Zn binding site [ion binding]; other site 941967000434 dimer interface [polypeptide binding]; other site 941967000435 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 941967000436 putative homodimer interface [polypeptide binding]; other site 941967000437 putative homotetramer interface [polypeptide binding]; other site 941967000438 putative metal binding site [ion binding]; other site 941967000439 putative homodimer-homodimer interface [polypeptide binding]; other site 941967000440 putative allosteric switch controlling residues; other site 941967000441 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 941967000442 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 941967000443 ATP binding site [chemical binding]; other site 941967000444 putative Mg++ binding site [ion binding]; other site 941967000445 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941967000446 nucleotide binding region [chemical binding]; other site 941967000447 ATP-binding site [chemical binding]; other site 941967000448 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 941967000449 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 941967000450 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941967000451 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941967000452 ATP binding site [chemical binding]; other site 941967000453 Mg2+ binding site [ion binding]; other site 941967000454 G-X-G motif; other site 941967000455 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 941967000456 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 941967000457 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 941967000458 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 941967000459 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941967000460 active site 941967000461 phosphorylation site [posttranslational modification] 941967000462 intermolecular recognition site; other site 941967000463 dimerization interface [polypeptide binding]; other site 941967000464 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 941967000465 Protein of unknown function (DUF1052); Region: DUF1052; pfam06319 941967000466 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 941967000467 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 941967000468 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 941967000469 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 941967000470 Universal stress protein family; Region: Usp; pfam00582 941967000471 Ligand Binding Site [chemical binding]; other site 941967000472 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 941967000473 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 941967000474 active site 941967000475 HIGH motif; other site 941967000476 dimer interface [polypeptide binding]; other site 941967000477 KMSKS motif; other site 941967000478 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 941967000479 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 941967000480 PII uridylyl-transferase; Provisional; Region: PRK05092 941967000481 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 941967000482 metal binding triad; other site 941967000483 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 941967000484 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 941967000485 Zn2+ binding site [ion binding]; other site 941967000486 Mg2+ binding site [ion binding]; other site 941967000487 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 941967000488 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 941967000489 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 941967000490 Malic enzyme, N-terminal domain; Region: malic; pfam00390 941967000491 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 941967000492 putative NAD(P) binding site [chemical binding]; other site 941967000493 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 941967000494 MutS domain I; Region: MutS_I; pfam01624 941967000495 MutS domain II; Region: MutS_II; pfam05188 941967000496 MutS domain III; Region: MutS_III; pfam05192 941967000497 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 941967000498 Walker A/P-loop; other site 941967000499 ATP binding site [chemical binding]; other site 941967000500 Q-loop/lid; other site 941967000501 ABC transporter signature motif; other site 941967000502 Walker B; other site 941967000503 D-loop; other site 941967000504 H-loop/switch region; other site 941967000505 Putative hemolysin [General function prediction only]; Region: COG3176 941967000506 lipoprotein signal peptidase; Provisional; Region: PRK14795 941967000507 lipoprotein signal peptidase; Provisional; Region: PRK14787 941967000508 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 941967000509 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 941967000510 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 941967000511 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 941967000512 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 941967000513 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 941967000514 IHF dimer interface [polypeptide binding]; other site 941967000515 IHF - DNA interface [nucleotide binding]; other site 941967000516 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 941967000517 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 941967000518 tandem repeat interface [polypeptide binding]; other site 941967000519 oligomer interface [polypeptide binding]; other site 941967000520 active site residues [active] 941967000521 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 941967000522 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 941967000523 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 941967000524 OstA-like protein; Region: OstA; pfam03968 941967000525 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 941967000526 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 941967000527 Walker A/P-loop; other site 941967000528 ATP binding site [chemical binding]; other site 941967000529 Q-loop/lid; other site 941967000530 ABC transporter signature motif; other site 941967000531 Walker B; other site 941967000532 D-loop; other site 941967000533 H-loop/switch region; other site 941967000534 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 941967000535 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 941967000536 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 941967000537 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 941967000538 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 941967000539 30S subunit binding site; other site 941967000540 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 941967000541 active site 941967000542 phosphorylation site [posttranslational modification] 941967000543 Uncharacterized small protein [Function unknown]; Region: COG5568 941967000544 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 941967000545 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 941967000546 putative dimer interface [polypeptide binding]; other site 941967000547 Integral membrane protein [Function unknown]; Region: COG5488 941967000548 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 941967000549 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 941967000550 minor groove reading motif; other site 941967000551 helix-hairpin-helix signature motif; other site 941967000552 substrate binding pocket [chemical binding]; other site 941967000553 active site 941967000554 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 941967000555 CysZ-like protein; Reviewed; Region: PRK12768 941967000556 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 941967000557 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 941967000558 substrate binding site [chemical binding]; other site 941967000559 ATP binding site [chemical binding]; other site 941967000560 UPF0126 domain; Region: UPF0126; pfam03458 941967000561 Predicted membrane protein [Function unknown]; Region: COG2860 941967000562 UPF0126 domain; Region: UPF0126; pfam03458 941967000563 heat shock protein GrpE; Provisional; Region: PRK14141 941967000564 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 941967000565 dimer interface [polypeptide binding]; other site 941967000566 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 941967000567 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 941967000568 ribonuclease PH; Reviewed; Region: rph; PRK00173 941967000569 Ribonuclease PH; Region: RNase_PH_bact; cd11362 941967000570 hexamer interface [polypeptide binding]; other site 941967000571 active site 941967000572 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 941967000573 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 941967000574 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 941967000575 active site 941967000576 dimerization interface [polypeptide binding]; other site 941967000577 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 941967000578 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941967000579 FeS/SAM binding site; other site 941967000580 HemN C-terminal domain; Region: HemN_C; pfam06969 941967000581 Predicted methyltransferases [General function prediction only]; Region: COG0313 941967000582 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 941967000583 putative SAM binding site [chemical binding]; other site 941967000584 putative homodimer interface [polypeptide binding]; other site 941967000585 hypothetical protein; Reviewed; Region: PRK12497 941967000586 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 941967000587 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 941967000588 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 941967000589 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 941967000590 active site 941967000591 SAM binding site [chemical binding]; other site 941967000592 homodimer interface [polypeptide binding]; other site 941967000593 Protein of unknown function (DUF2849); Region: DUF2849; pfam11011 941967000594 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 941967000595 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 941967000596 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 941967000597 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 941967000598 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 941967000599 Active Sites [active] 941967000600 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3749 941967000601 Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876 941967000602 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 941967000603 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 941967000604 active site 941967000605 DNA binding site [nucleotide binding] 941967000606 BA14K-like protein; Region: BA14K; pfam07886 941967000607 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 941967000608 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 941967000609 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 941967000610 substrate binding pocket [chemical binding]; other site 941967000611 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 941967000612 B12 binding site [chemical binding]; other site 941967000613 cobalt ligand [ion binding]; other site 941967000614 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 941967000615 Autoinducer binding domain; Region: Autoind_bind; pfam03472 941967000616 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 941967000617 DNA binding residues [nucleotide binding] 941967000618 aminotransferase; Provisional; Region: PRK06105 941967000619 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 941967000620 inhibitor-cofactor binding pocket; inhibition site 941967000621 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941967000622 catalytic residue [active] 941967000623 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 941967000624 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 941967000625 Active Sites [active] 941967000626 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 941967000627 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 941967000628 CysD dimerization site [polypeptide binding]; other site 941967000629 G1 box; other site 941967000630 putative GEF interaction site [polypeptide binding]; other site 941967000631 GTP/Mg2+ binding site [chemical binding]; other site 941967000632 Switch I region; other site 941967000633 G2 box; other site 941967000634 G3 box; other site 941967000635 Switch II region; other site 941967000636 G4 box; other site 941967000637 G5 box; other site 941967000638 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 941967000639 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 941967000640 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 941967000641 ligand-binding site [chemical binding]; other site 941967000642 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 941967000643 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 941967000644 active site 941967000645 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 941967000646 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 941967000647 ligand binding site [chemical binding]; other site 941967000648 flexible hinge region; other site 941967000649 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 941967000650 putative switch regulator; other site 941967000651 non-specific DNA interactions [nucleotide binding]; other site 941967000652 DNA binding site [nucleotide binding] 941967000653 sequence specific DNA binding site [nucleotide binding]; other site 941967000654 putative cAMP binding site [chemical binding]; other site 941967000655 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 941967000656 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 941967000657 active site 941967000658 dimerization interface [polypeptide binding]; other site 941967000659 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 941967000660 DNA binding residues [nucleotide binding] 941967000661 dimerization interface [polypeptide binding]; other site 941967000662 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 941967000663 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 941967000664 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 941967000665 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 941967000666 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 941967000667 GAF domain; Region: GAF; pfam01590 941967000668 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 941967000669 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 941967000670 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 941967000671 NAD(P) binding site [chemical binding]; other site 941967000672 catalytic residues [active] 941967000673 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 941967000674 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 941967000675 NAD binding site [chemical binding]; other site 941967000676 substrate binding site [chemical binding]; other site 941967000677 catalytic Zn binding site [ion binding]; other site 941967000678 tetramer interface [polypeptide binding]; other site 941967000679 structural Zn binding site [ion binding]; other site 941967000680 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3564 941967000681 Transcriptional regulators [Transcription]; Region: PurR; COG1609 941967000682 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 941967000683 DNA binding site [nucleotide binding] 941967000684 domain linker motif; other site 941967000685 Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545 941967000686 putative dimerization interface [polypeptide binding]; other site 941967000687 putative ligand binding site [chemical binding]; other site 941967000688 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941967000689 ABC transporter; Region: ABC_tran; pfam00005 941967000690 Q-loop/lid; other site 941967000691 ABC transporter signature motif; other site 941967000692 Walker B; other site 941967000693 D-loop; other site 941967000694 H-loop/switch region; other site 941967000695 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 941967000696 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 941967000697 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941967000698 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 941967000699 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 941967000700 NAD(P) binding site [chemical binding]; other site 941967000701 catalytic residues [active] 941967000702 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 941967000703 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 941967000704 Putative transcription activator [Transcription]; Region: TenA; COG0819 941967000705 NMT1/THI5 like; Region: NMT1; pfam09084 941967000706 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 941967000707 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 941967000708 active site 941967000709 thiamine phosphate binding site [chemical binding]; other site 941967000710 pyrophosphate binding site [ion binding]; other site 941967000711 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 941967000712 ThiS interaction site; other site 941967000713 putative active site [active] 941967000714 tetramer interface [polypeptide binding]; other site 941967000715 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 941967000716 thiS-thiF/thiG interaction site; other site 941967000717 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 941967000718 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 941967000719 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 941967000720 dimer interface [polypeptide binding]; other site 941967000721 substrate binding site [chemical binding]; other site 941967000722 ATP binding site [chemical binding]; other site 941967000723 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941967000724 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 941967000725 putative active site [active] 941967000726 heme pocket [chemical binding]; other site 941967000727 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941967000728 putative active site [active] 941967000729 heme pocket [chemical binding]; other site 941967000730 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941967000731 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941967000732 metal binding site [ion binding]; metal-binding site 941967000733 active site 941967000734 I-site; other site 941967000735 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 941967000736 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 941967000737 metal-binding site [ion binding] 941967000738 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 941967000739 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 941967000740 metal-binding site [ion binding] 941967000741 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 941967000742 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 941967000743 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 941967000744 DNA binding residues [nucleotide binding] 941967000745 dimer interface [polypeptide binding]; other site 941967000746 copper binding site [ion binding]; other site 941967000747 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967000748 dimer interface [polypeptide binding]; other site 941967000749 conserved gate region; other site 941967000750 putative PBP binding loops; other site 941967000751 ABC-ATPase subunit interface; other site 941967000752 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 941967000753 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 941967000754 Walker A/P-loop; other site 941967000755 ATP binding site [chemical binding]; other site 941967000756 Q-loop/lid; other site 941967000757 ABC transporter signature motif; other site 941967000758 Walker B; other site 941967000759 D-loop; other site 941967000760 H-loop/switch region; other site 941967000761 CBS domain; Region: CBS; pfam00571 941967000762 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967000763 dimer interface [polypeptide binding]; other site 941967000764 conserved gate region; other site 941967000765 ABC-ATPase subunit interface; other site 941967000766 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 941967000767 nitrobindin heme-binding domain; Region: nitrobindin; cl10502 941967000768 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 941967000769 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 941967000770 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 941967000771 NAD(P) binding site [chemical binding]; other site 941967000772 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 941967000773 hydroxyglutarate oxidase; Provisional; Region: PRK11728 941967000774 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 941967000775 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 941967000776 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 941967000777 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 941967000778 Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583 941967000779 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 941967000780 Amidohydrolase; Region: Amidohydro_2; pfam04909 941967000781 active site 941967000782 Transcriptional regulator [Transcription]; Region: IclR; COG1414 941967000783 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 941967000784 putative DNA binding site [nucleotide binding]; other site 941967000785 putative Zn2+ binding site [ion binding]; other site 941967000786 Bacterial transcriptional regulator; Region: IclR; pfam01614 941967000787 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 941967000788 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 941967000789 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967000790 dimer interface [polypeptide binding]; other site 941967000791 conserved gate region; other site 941967000792 putative PBP binding loops; other site 941967000793 ABC-ATPase subunit interface; other site 941967000794 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 941967000795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967000796 dimer interface [polypeptide binding]; other site 941967000797 conserved gate region; other site 941967000798 putative PBP binding loops; other site 941967000799 ABC-ATPase subunit interface; other site 941967000800 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 941967000801 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 941967000802 Walker A/P-loop; other site 941967000803 ATP binding site [chemical binding]; other site 941967000804 Q-loop/lid; other site 941967000805 ABC transporter signature motif; other site 941967000806 Walker B; other site 941967000807 D-loop; other site 941967000808 H-loop/switch region; other site 941967000809 TOBE domain; Region: TOBE_2; pfam08402 941967000810 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 941967000811 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 941967000812 active site pocket [active] 941967000813 Uncharacterized conserved protein [Function unknown]; Region: COG3254 941967000814 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 941967000815 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 941967000816 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 941967000817 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 941967000818 NAD binding site [chemical binding]; other site 941967000819 homotetramer interface [polypeptide binding]; other site 941967000820 homodimer interface [polypeptide binding]; other site 941967000821 active site 941967000822 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 941967000823 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 941967000824 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 941967000825 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 941967000826 putative active site pocket [active] 941967000827 metal binding site [ion binding]; metal-binding site 941967000828 integrase; Provisional; Region: PRK09692 941967000829 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 941967000830 active site 941967000831 Int/Topo IB signature motif; other site 941967000832 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 941967000833 Toprim domain; Region: Toprim_3; pfam13362 941967000834 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 941967000835 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 941967000836 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 941967000837 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 941967000838 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 941967000839 non-specific DNA binding site [nucleotide binding]; other site 941967000840 salt bridge; other site 941967000841 sequence-specific DNA binding site [nucleotide binding]; other site 941967000842 TIR domain; Region: TIR_2; pfam13676 941967000843 zinc-binding protein; Provisional; Region: PRK01343 941967000844 Maf-like protein; Region: Maf; pfam02545 941967000845 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 941967000846 active site 941967000847 dimer interface [polypeptide binding]; other site 941967000848 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 941967000849 rRNA binding site [nucleotide binding]; other site 941967000850 predicted 30S ribosome binding site; other site 941967000851 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 941967000852 Low molecular weight phosphatase family; Region: LMWPc; cd00115 941967000853 active site 941967000854 hypothetical protein; Provisional; Region: PRK02853 941967000855 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 941967000856 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 941967000857 NAD binding site [chemical binding]; other site 941967000858 dimerization interface [polypeptide binding]; other site 941967000859 product binding site; other site 941967000860 substrate binding site [chemical binding]; other site 941967000861 zinc binding site [ion binding]; other site 941967000862 catalytic residues [active] 941967000863 Protein of unknown function (DUF2948); Region: DUF2948; pfam11164 941967000864 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 941967000865 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 941967000866 hinge; other site 941967000867 active site 941967000868 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 941967000869 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 941967000870 INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184 941967000871 Int/Topo IB signature motif; other site 941967000872 BRO family, N-terminal domain; Region: Bro-N; smart01040 941967000873 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 941967000874 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 941967000875 catalytic residues [active] 941967000876 catalytic nucleophile [active] 941967000877 Presynaptic Site I dimer interface [polypeptide binding]; other site 941967000878 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 941967000879 Synaptic Flat tetramer interface [polypeptide binding]; other site 941967000880 Synaptic Site I dimer interface [polypeptide binding]; other site 941967000881 DNA binding site [nucleotide binding] 941967000882 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cl00541 941967000883 dimerization interface [polypeptide binding]; other site 941967000884 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 941967000885 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 941967000886 alpha-gamma subunit interface [polypeptide binding]; other site 941967000887 beta-gamma subunit interface [polypeptide binding]; other site 941967000888 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 941967000889 gamma-beta subunit interface [polypeptide binding]; other site 941967000890 alpha-beta subunit interface [polypeptide binding]; other site 941967000891 urease subunit alpha; Reviewed; Region: ureC; PRK13207 941967000892 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 941967000893 subunit interactions [polypeptide binding]; other site 941967000894 active site 941967000895 flap region; other site 941967000896 Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371 941967000897 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 941967000898 dimer interface [polypeptide binding]; other site 941967000899 catalytic residues [active] 941967000900 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 941967000901 UreF; Region: UreF; pfam01730 941967000902 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 941967000903 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941967000904 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941967000905 ATP binding site [chemical binding]; other site 941967000906 Mg2+ binding site [ion binding]; other site 941967000907 G-X-G motif; other site 941967000908 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 941967000909 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 941967000910 HlyD family secretion protein; Region: HlyD_3; pfam13437 941967000911 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 941967000912 phenylhydantoinase; Validated; Region: PRK08323 941967000913 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 941967000914 tetramer interface [polypeptide binding]; other site 941967000915 active site 941967000916 allantoate amidohydrolase; Reviewed; Region: PRK12893 941967000917 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 941967000918 active site 941967000919 metal binding site [ion binding]; metal-binding site 941967000920 dimer interface [polypeptide binding]; other site 941967000921 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941967000922 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 941967000923 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 941967000924 nudix motif; other site 941967000925 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 941967000926 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 941967000927 homodimer interface [polypeptide binding]; other site 941967000928 active site 941967000929 FMN binding site [chemical binding]; other site 941967000930 substrate binding site [chemical binding]; other site 941967000931 4Fe-4S binding domain; Region: Fer4; cl02805 941967000932 4Fe-4S binding domain; Region: Fer4; pfam00037 941967000933 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 941967000934 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 941967000935 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 941967000936 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 941967000937 putative hydrophobic ligand binding site [chemical binding]; other site 941967000938 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 941967000939 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 941967000940 active site 941967000941 dimer interface [polypeptide binding]; other site 941967000942 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 941967000943 dimer interface [polypeptide binding]; other site 941967000944 active site 941967000945 Predicted deacylase [General function prediction only]; Region: COG3608 941967000946 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 941967000947 active site 941967000948 Zn binding site [ion binding]; other site 941967000949 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 941967000950 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941967000951 motif II; other site 941967000952 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 941967000953 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 941967000954 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 941967000955 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 941967000956 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 941967000957 acyl-activating enzyme (AAE) consensus motif; other site 941967000958 putative AMP binding site [chemical binding]; other site 941967000959 putative active site [active] 941967000960 putative CoA binding site [chemical binding]; other site 941967000961 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 941967000962 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941967000963 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 941967000964 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 941967000965 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 941967000966 HlyD family secretion protein; Region: HlyD_3; pfam13437 941967000967 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 941967000968 Protein export membrane protein; Region: SecD_SecF; cl14618 941967000969 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 941967000970 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941967000971 substrate binding pocket [chemical binding]; other site 941967000972 membrane-bound complex binding site; other site 941967000973 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 941967000974 CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427 941967000975 DXD motif; other site 941967000976 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 941967000977 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941967000978 dimer interface [polypeptide binding]; other site 941967000979 phosphorylation site [posttranslational modification] 941967000980 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941967000981 ATP binding site [chemical binding]; other site 941967000982 Mg2+ binding site [ion binding]; other site 941967000983 G-X-G motif; other site 941967000984 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5352 941967000985 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 941967000986 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 941967000987 inhibitor-cofactor binding pocket; inhibition site 941967000988 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941967000989 catalytic residue [active] 941967000990 ornithine carbamoyltransferase; Provisional; Region: PRK00779 941967000991 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 941967000992 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 941967000993 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 941967000994 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 941967000995 dimerization interface [polypeptide binding]; other site 941967000996 domain crossover interface; other site 941967000997 redox-dependent activation switch; other site 941967000998 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 941967000999 O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504 941967001000 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 941967001001 homodimer interface [polypeptide binding]; other site 941967001002 substrate-cofactor binding pocket; other site 941967001003 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941967001004 catalytic residue [active] 941967001005 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 941967001006 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 941967001007 trimer interface [polypeptide binding]; other site 941967001008 active site 941967001009 Deoxycytidine deaminase [Nucleotide transport and metabolism]; Region: Dcd; COG0717 941967001010 trimer interface [polypeptide binding]; other site 941967001011 active site 941967001012 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 941967001013 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 941967001014 conserved cys residue [active] 941967001015 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 941967001016 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 941967001017 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 941967001018 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 941967001019 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 941967001020 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 941967001021 quinone interaction residues [chemical binding]; other site 941967001022 active site 941967001023 catalytic residues [active] 941967001024 FMN binding site [chemical binding]; other site 941967001025 substrate binding site [chemical binding]; other site 941967001026 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 941967001027 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 941967001028 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 941967001029 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 941967001030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941967001031 active site 941967001032 phosphorylation site [posttranslational modification] 941967001033 intermolecular recognition site; other site 941967001034 dimerization interface [polypeptide binding]; other site 941967001035 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 941967001036 DNA binding residues [nucleotide binding] 941967001037 dimerization interface [polypeptide binding]; other site 941967001038 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 941967001039 Na binding site [ion binding]; other site 941967001040 PAS fold; Region: PAS_7; pfam12860 941967001041 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941967001042 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941967001043 dimer interface [polypeptide binding]; other site 941967001044 phosphorylation site [posttranslational modification] 941967001045 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941967001046 ATP binding site [chemical binding]; other site 941967001047 Mg2+ binding site [ion binding]; other site 941967001048 G-X-G motif; other site 941967001049 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 941967001050 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941967001051 active site 941967001052 phosphorylation site [posttranslational modification] 941967001053 intermolecular recognition site; other site 941967001054 dimerization interface [polypeptide binding]; other site 941967001055 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 941967001056 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 941967001057 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 941967001058 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 941967001059 substrate-cofactor binding pocket; other site 941967001060 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941967001061 catalytic residue [active] 941967001062 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 941967001063 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 941967001064 putative active site [active] 941967001065 putative metal binding site [ion binding]; other site 941967001066 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 941967001067 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 941967001068 Glycosyltransferase family 29 (sialyltransferase); Region: Glyco_transf_29; pfam00777 941967001069 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941967001070 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941967001071 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 941967001072 putative dimerization interface [polypeptide binding]; other site 941967001073 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 941967001074 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 941967001075 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 941967001076 pantoate--beta-alanine ligase; Region: panC; TIGR00018 941967001077 Pantoate-beta-alanine ligase; Region: PanC; cd00560 941967001078 active site 941967001079 ATP-binding site [chemical binding]; other site 941967001080 pantoate-binding site; other site 941967001081 HXXH motif; other site 941967001082 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 941967001083 active site 941967001084 oligomerization interface [polypeptide binding]; other site 941967001085 metal binding site [ion binding]; metal-binding site 941967001086 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 941967001087 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 941967001088 FAD binding pocket [chemical binding]; other site 941967001089 FAD binding motif [chemical binding]; other site 941967001090 phosphate binding motif [ion binding]; other site 941967001091 beta-alpha-beta structure motif; other site 941967001092 NAD binding pocket [chemical binding]; other site 941967001093 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 941967001094 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 941967001095 dimer interface [polypeptide binding]; other site 941967001096 active site 941967001097 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 941967001098 catalytic residues [active] 941967001099 substrate binding site [chemical binding]; other site 941967001100 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 941967001101 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 941967001102 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 941967001103 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 941967001104 multidrug efflux protein; Reviewed; Region: PRK01766 941967001105 cation binding site [ion binding]; other site 941967001106 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 941967001107 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 941967001108 Cache domain; Region: Cache_2; pfam08269 941967001109 Histidine kinase; Region: HisKA_3; pfam07730 941967001110 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941967001111 ATP binding site [chemical binding]; other site 941967001112 Mg2+ binding site [ion binding]; other site 941967001113 G-X-G motif; other site 941967001114 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 941967001115 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941967001116 active site 941967001117 phosphorylation site [posttranslational modification] 941967001118 intermolecular recognition site; other site 941967001119 dimerization interface [polypeptide binding]; other site 941967001120 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 941967001121 DNA binding residues [nucleotide binding] 941967001122 dimerization interface [polypeptide binding]; other site 941967001123 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 941967001124 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 941967001125 DctM-like transporters; Region: DctM; pfam06808 941967001126 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 941967001127 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 941967001128 hypothetical protein; Provisional; Region: PRK11171 941967001129 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 941967001130 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 941967001131 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 941967001132 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 941967001133 active site 941967001134 catalytic site [active] 941967001135 tetramer interface [polypeptide binding]; other site 941967001136 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 941967001137 Transthyretin_like. This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase). TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl17222 941967001138 homotetramer interface [polypeptide binding]; other site 941967001139 active site 941967001140 Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [Nucleotide transport and metabolism]; Region: XdhA; COG4630 941967001141 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 941967001142 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 941967001143 Xanthine dehydrogenase, molybdopterin-binding subunit B [Nucleotide transport and metabolism]; Region: XdhB; COG4631 941967001144 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 941967001145 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 941967001146 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 941967001147 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 941967001148 XdhC Rossmann domain; Region: XdhC_C; pfam13478 941967001149 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 941967001150 putative effector binding pocket; other site 941967001151 dimerization interface [polypeptide binding]; other site 941967001152 Predicted membrane protein [Function unknown]; Region: COG3748 941967001153 Protein of unknown function (DUF989); Region: DUF989; pfam06181 941967001154 Cytochrome c; Region: Cytochrom_C; pfam00034 941967001155 guanine deaminase; Provisional; Region: PRK09228 941967001156 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 941967001157 active site 941967001158 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 941967001159 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 941967001160 MOFRL family; Region: MOFRL; pfam05161 941967001161 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 941967001162 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 941967001163 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 941967001164 metal-binding site [ion binding] 941967001165 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 941967001166 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941967001167 motif II; other site 941967001168 Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456 941967001169 FixH; Region: FixH; pfam05751 941967001170 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 941967001171 4Fe-4S binding domain; Region: Fer4_5; pfam12801 941967001172 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 941967001173 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 941967001174 Cytochrome c; Region: Cytochrom_C; pfam00034 941967001175 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 941967001176 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 941967001177 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 941967001178 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 941967001179 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 941967001180 Low-spin heme binding site [chemical binding]; other site 941967001181 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 941967001182 Putative water exit pathway; other site 941967001183 Binuclear center (active site) [active] 941967001184 Putative proton exit pathway; other site 941967001185 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 941967001186 metal binding site 2 [ion binding]; metal-binding site 941967001187 putative DNA binding helix; other site 941967001188 metal binding site 1 [ion binding]; metal-binding site 941967001189 dimer interface [polypeptide binding]; other site 941967001190 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 941967001191 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 941967001192 catalytic residues [active] 941967001193 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 941967001194 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 941967001195 NAD(P) binding site [chemical binding]; other site 941967001196 catalytic residues [active] 941967001197 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 941967001198 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 941967001199 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 941967001200 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941967001201 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941967001202 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 941967001203 DNA binding site [nucleotide binding] 941967001204 active site 941967001205 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 941967001206 ArsC family; Region: ArsC; pfam03960 941967001207 putative catalytic residues [active] 941967001208 Predicted membrane protein [Function unknown]; Region: COG4129 941967001209 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 941967001210 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941967001211 putative substrate translocation pore; other site 941967001212 D-galactonate transporter; Region: 2A0114; TIGR00893 941967001213 microcin B17 transporter; Reviewed; Region: PRK11098 941967001214 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 941967001215 GTP-binding protein Der; Reviewed; Region: PRK00093 941967001216 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 941967001217 G1 box; other site 941967001218 GTP/Mg2+ binding site [chemical binding]; other site 941967001219 Switch I region; other site 941967001220 G2 box; other site 941967001221 Switch II region; other site 941967001222 G3 box; other site 941967001223 G4 box; other site 941967001224 G5 box; other site 941967001225 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 941967001226 G1 box; other site 941967001227 GTP/Mg2+ binding site [chemical binding]; other site 941967001228 Switch I region; other site 941967001229 G2 box; other site 941967001230 G3 box; other site 941967001231 Switch II region; other site 941967001232 G4 box; other site 941967001233 G5 box; other site 941967001234 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 941967001235 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 941967001236 nucleotide binding site [chemical binding]; other site 941967001237 putative NEF/HSP70 interaction site [polypeptide binding]; other site 941967001238 SBD interface [polypeptide binding]; other site 941967001239 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 941967001240 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 941967001241 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5336 941967001242 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 941967001243 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 941967001244 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 941967001245 F0F1 ATP synthase subunit B'; Validated; Region: PRK09174 941967001246 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 941967001247 F0F1 ATP synthase subunit B; Validated; Region: PRK09173 941967001248 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 941967001249 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 941967001250 RNA/DNA hybrid binding site [nucleotide binding]; other site 941967001251 active site 941967001252 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 941967001253 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941967001254 FeS/SAM binding site; other site 941967001255 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 941967001256 active site 941967001257 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 941967001258 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 941967001259 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 941967001260 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 941967001261 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 941967001262 tandem repeat interface [polypeptide binding]; other site 941967001263 oligomer interface [polypeptide binding]; other site 941967001264 active site residues [active] 941967001265 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 941967001266 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941967001267 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 941967001268 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 941967001269 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 941967001270 substrate binding pocket [chemical binding]; other site 941967001271 chain length determination region; other site 941967001272 substrate-Mg2+ binding site; other site 941967001273 catalytic residues [active] 941967001274 aspartate-rich region 1; other site 941967001275 active site lid residues [active] 941967001276 aspartate-rich region 2; other site 941967001277 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 941967001278 binding surface 941967001279 TPR motif; other site 941967001280 TPR repeat; Region: TPR_11; pfam13414 941967001281 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 941967001282 binding surface 941967001283 TPR motif; other site 941967001284 TPR repeat; Region: TPR_11; pfam13414 941967001285 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 941967001286 binding surface 941967001287 TPR motif; other site 941967001288 TPR repeat; Region: TPR_11; pfam13414 941967001289 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 941967001290 dimer interface [polypeptide binding]; other site 941967001291 motif 1; other site 941967001292 active site 941967001293 motif 2; other site 941967001294 motif 3; other site 941967001295 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 941967001296 DALR anticodon binding domain; Region: DALR_1; pfam05746 941967001297 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 941967001298 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 941967001299 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 941967001300 FAD binding domain; Region: FAD_binding_4; pfam01565 941967001301 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 941967001302 enoyl-CoA hydratase; Provisional; Region: PRK06688 941967001303 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 941967001304 substrate binding site [chemical binding]; other site 941967001305 oxyanion hole (OAH) forming residues; other site 941967001306 trimer interface [polypeptide binding]; other site 941967001307 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 941967001308 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 941967001309 active site 941967001310 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 941967001311 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941967001312 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941967001313 metal binding site [ion binding]; metal-binding site 941967001314 active site 941967001315 I-site; other site 941967001316 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 941967001317 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 941967001318 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 941967001319 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 941967001320 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878 941967001321 UbiA prenyltransferase family; Region: UbiA; pfam01040 941967001322 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 941967001323 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 941967001324 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 941967001325 chaperone protein DnaJ; Provisional; Region: PRK14299 941967001326 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 941967001327 HSP70 interaction site [polypeptide binding]; other site 941967001328 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 941967001329 dimer interface [polypeptide binding]; other site 941967001330 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 941967001331 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 941967001332 NAD binding site [chemical binding]; other site 941967001333 homotetramer interface [polypeptide binding]; other site 941967001334 homodimer interface [polypeptide binding]; other site 941967001335 substrate binding site [chemical binding]; other site 941967001336 active site 941967001337 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 941967001338 catalytic core [active] 941967001339 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 941967001340 DNA-binding site [nucleotide binding]; DNA binding site 941967001341 RNA-binding motif; other site 941967001342 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 941967001343 putative acyl-acceptor binding pocket; other site 941967001344 Protein of unknown function (DUF1344); Region: DUF1344; pfam07076 941967001345 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 941967001346 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 941967001347 Tetramer interface [polypeptide binding]; other site 941967001348 active site 941967001349 FMN-binding site [chemical binding]; other site 941967001350 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 941967001351 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 941967001352 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 941967001353 dimerization interface [polypeptide binding]; other site 941967001354 active site 941967001355 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 941967001356 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 941967001357 putative active site [active] 941967001358 Zn binding site [ion binding]; other site 941967001359 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 941967001360 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 941967001361 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 941967001362 Predicted membrane protein [Function unknown]; Region: COG2261 941967001363 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3753 941967001364 Pirin-related protein [General function prediction only]; Region: COG1741 941967001365 Pirin; Region: Pirin; pfam02678 941967001366 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 941967001367 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 941967001368 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 941967001369 TPP-binding site; other site 941967001370 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 941967001371 PYR/PP interface [polypeptide binding]; other site 941967001372 dimer interface [polypeptide binding]; other site 941967001373 TPP binding site [chemical binding]; other site 941967001374 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 941967001375 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 941967001376 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 941967001377 RNA binding surface [nucleotide binding]; other site 941967001378 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941967001379 S-adenosylmethionine binding site [chemical binding]; other site 941967001380 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 941967001381 Methyltransferase domain; Region: Methyltransf_26; pfam13659 941967001382 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 941967001383 Predicted periplasmic protein [General function prediction only]; Region: COG3895 941967001384 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 941967001385 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 941967001386 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 941967001387 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 941967001388 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 941967001389 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 941967001390 Walker A/P-loop; other site 941967001391 ATP binding site [chemical binding]; other site 941967001392 Q-loop/lid; other site 941967001393 ABC transporter signature motif; other site 941967001394 Walker B; other site 941967001395 D-loop; other site 941967001396 H-loop/switch region; other site 941967001397 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 941967001398 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 941967001399 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 941967001400 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 941967001401 classical (c) SDRs; Region: SDR_c; cd05233 941967001402 NAD(P) binding site [chemical binding]; other site 941967001403 active site 941967001404 amidophosphoribosyltransferase; Provisional; Region: PRK09123 941967001405 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 941967001406 active site 941967001407 tetramer interface [polypeptide binding]; other site 941967001408 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 941967001409 active site 941967001410 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 941967001411 Colicin V production protein; Region: Colicin_V; pfam02674 941967001412 DNA repair protein RadA; Provisional; Region: PRK11823 941967001413 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 941967001414 Walker A motif/ATP binding site; other site 941967001415 ATP binding site [chemical binding]; other site 941967001416 Walker B motif; other site 941967001417 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 941967001418 replicative DNA helicase; Provisional; Region: PRK09165 941967001419 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 941967001420 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 941967001421 Walker A motif; other site 941967001422 ATP binding site [chemical binding]; other site 941967001423 Walker B motif; other site 941967001424 DNA binding loops [nucleotide binding] 941967001425 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 941967001426 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941967001427 S-adenosylmethionine binding site [chemical binding]; other site 941967001428 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 941967001429 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 941967001430 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 941967001431 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 941967001432 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 941967001433 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 941967001434 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 941967001435 3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936 941967001436 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 941967001437 NAD(P) binding site [chemical binding]; other site 941967001438 homotetramer interface [polypeptide binding]; other site 941967001439 homodimer interface [polypeptide binding]; other site 941967001440 active site 941967001441 acyl carrier protein; Provisional; Region: acpP; PRK00982 941967001442 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 941967001443 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 941967001444 dimer interface [polypeptide binding]; other site 941967001445 active site 941967001446 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 941967001447 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 941967001448 dimerization interface [polypeptide binding]; other site 941967001449 Uncharacterized stress-induced protein [Function unknown]; Region: COG1561 941967001450 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 941967001451 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 941967001452 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 941967001453 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 941967001454 catalytic site [active] 941967001455 G-X2-G-X-G-K; other site 941967001456 protease TldD; Provisional; Region: tldD; PRK10735 941967001457 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 941967001458 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 941967001459 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 941967001460 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 941967001461 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 941967001462 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 941967001463 Subunit I/III interface [polypeptide binding]; other site 941967001464 D-pathway; other site 941967001465 Subunit I/VIIc interface [polypeptide binding]; other site 941967001466 Subunit I/IV interface [polypeptide binding]; other site 941967001467 Subunit I/II interface [polypeptide binding]; other site 941967001468 Low-spin heme (heme a) binding site [chemical binding]; other site 941967001469 Subunit I/VIIa interface [polypeptide binding]; other site 941967001470 Subunit I/VIa interface [polypeptide binding]; other site 941967001471 Dimer interface; other site 941967001472 Putative water exit pathway; other site 941967001473 Binuclear center (heme a3/CuB) [ion binding]; other site 941967001474 K-pathway; other site 941967001475 Subunit I/Vb interface [polypeptide binding]; other site 941967001476 Putative proton exit pathway; other site 941967001477 Subunit I/VIb interface; other site 941967001478 Subunit I/VIc interface [polypeptide binding]; other site 941967001479 Electron transfer pathway; other site 941967001480 Subunit I/VIIIb interface [polypeptide binding]; other site 941967001481 Subunit I/VIIb interface [polypeptide binding]; other site 941967001482 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 941967001483 UbiA prenyltransferase family; Region: UbiA; pfam01040 941967001484 Cytochrome oxidase assembly factor [Posttranslational modification, protein turnover, chaperones]; Region: COX11; COG3175 941967001485 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 941967001486 Subunit III/VIIa interface [polypeptide binding]; other site 941967001487 Phospholipid binding site [chemical binding]; other site 941967001488 Subunit I/III interface [polypeptide binding]; other site 941967001489 Subunit III/VIb interface [polypeptide binding]; other site 941967001490 Subunit III/VIa interface; other site 941967001491 Subunit III/Vb interface [polypeptide binding]; other site 941967001492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349 941967001493 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 941967001494 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 941967001495 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 941967001496 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 941967001497 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 941967001498 putative active site [active] 941967001499 putative substrate binding site [chemical binding]; other site 941967001500 ATP binding site [chemical binding]; other site 941967001501 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 941967001502 RNA/DNA hybrid binding site [nucleotide binding]; other site 941967001503 active site 941967001504 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 941967001505 catalytic triad [active] 941967001506 dimer interface [polypeptide binding]; other site 941967001507 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 941967001508 hypothetical protein; Validated; Region: PRK00228 941967001509 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 941967001510 PAS fold; Region: PAS_3; pfam08447 941967001511 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941967001512 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941967001513 metal binding site [ion binding]; metal-binding site 941967001514 active site 941967001515 I-site; other site 941967001516 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 941967001517 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 941967001518 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 941967001519 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 941967001520 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 941967001521 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 941967001522 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 941967001523 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 941967001524 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941967001525 catalytic residue [active] 941967001526 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 941967001527 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 941967001528 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 941967001529 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 941967001530 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941967001531 active site 941967001532 motif I; other site 941967001533 motif II; other site 941967001534 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 941967001535 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 941967001536 Cl- selectivity filter; other site 941967001537 Cl- binding residues [ion binding]; other site 941967001538 pore gating glutamate residue; other site 941967001539 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 941967001540 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 941967001541 DNA methylase; Region: N6_N4_Mtase; pfam01555 941967001542 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 941967001543 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941967001544 motif II; other site 941967001545 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 941967001546 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 941967001547 minor groove reading motif; other site 941967001548 helix-hairpin-helix signature motif; other site 941967001549 substrate binding pocket [chemical binding]; other site 941967001550 active site 941967001551 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 941967001552 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 941967001553 DNA binding and oxoG recognition site [nucleotide binding] 941967001554 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5389 941967001555 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 941967001556 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 941967001557 catalytic residues [active] 941967001558 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 941967001559 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 941967001560 Walker A/P-loop; other site 941967001561 ATP binding site [chemical binding]; other site 941967001562 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 941967001563 ABC transporter signature motif; other site 941967001564 Walker B; other site 941967001565 D-loop; other site 941967001566 H-loop/switch region; other site 941967001567 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 941967001568 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 941967001569 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 941967001570 pyruvate phosphate dikinase; Provisional; Region: PRK09279 941967001571 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 941967001572 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 941967001573 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 941967001574 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 941967001575 Putative catalytic NodB homology domain of uncharacterized BH0857 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH0857_like; cd10955 941967001576 NodB motif; other site 941967001577 putative active site [active] 941967001578 putative catalytic site [active] 941967001579 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 941967001580 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 941967001581 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 941967001582 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 941967001583 ureidoglycolate hydrolase; Provisional; Region: PRK03606 941967001584 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 941967001585 active site 941967001586 homotetramer interface [polypeptide binding]; other site 941967001587 Protein of unknown function (DUF2793); Region: DUF2793; pfam10983 941967001588 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 941967001589 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 941967001590 NAD(P) binding site [chemical binding]; other site 941967001591 homodimer interface [polypeptide binding]; other site 941967001592 substrate binding site [chemical binding]; other site 941967001593 active site 941967001594 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 941967001595 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 941967001596 Mg++ binding site [ion binding]; other site 941967001597 putative catalytic motif [active] 941967001598 putative substrate binding site [chemical binding]; other site 941967001599 Homeodomain-like domain; Region: HTH_23; cl17451 941967001600 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 941967001601 Integrase core domain; Region: rve_3; pfam13683 941967001602 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 941967001603 Integrase core domain; Region: rve; pfam00665 941967001604 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 941967001605 catalytic site [active] 941967001606 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 941967001607 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 941967001608 inhibitor-cofactor binding pocket; inhibition site 941967001609 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941967001610 catalytic residue [active] 941967001611 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 941967001612 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 941967001613 NADP-binding site; other site 941967001614 homotetramer interface [polypeptide binding]; other site 941967001615 substrate binding site [chemical binding]; other site 941967001616 homodimer interface [polypeptide binding]; other site 941967001617 active site 941967001618 Integrase core domain; Region: rve; pfam00665 941967001619 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 941967001620 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 941967001621 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 941967001622 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 941967001623 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 941967001624 Integrase core domain; Region: rve; pfam00665 941967001625 Integrase core domain; Region: rve; pfam00665 941967001626 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 941967001627 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 941967001628 Integrase core domain; Region: rve_3; cl15866 941967001629 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 941967001630 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 941967001631 active site 941967001632 substrate binding site [chemical binding]; other site 941967001633 metal binding site [ion binding]; metal-binding site 941967001634 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 941967001635 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 941967001636 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 941967001637 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 941967001638 dimerization interface [polypeptide binding]; other site 941967001639 putative active cleft [active] 941967001640 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 941967001641 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 941967001642 putative ADP-binding pocket [chemical binding]; other site 941967001643 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 941967001644 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 941967001645 Walker A/P-loop; other site 941967001646 ATP binding site [chemical binding]; other site 941967001647 Q-loop/lid; other site 941967001648 ABC transporter signature motif; other site 941967001649 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 941967001650 Q-loop/lid; other site 941967001651 ABC transporter signature motif; other site 941967001652 Walker B; other site 941967001653 D-loop; other site 941967001654 H-loop/switch region; other site 941967001655 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 941967001656 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 941967001657 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 941967001658 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 941967001659 TM-ABC transporter signature motif; other site 941967001660 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 941967001661 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_3; cd06311 941967001662 putative ligand binding site [chemical binding]; other site 941967001663 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 941967001664 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 941967001665 Metal-binding active site; metal-binding site 941967001666 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 941967001667 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 941967001668 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 941967001669 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 941967001670 xylose isomerase; Provisional; Region: PRK05474 941967001671 xylose isomerase; Region: xylose_isom_A; TIGR02630 941967001672 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 941967001673 N- and C-terminal domain interface [polypeptide binding]; other site 941967001674 D-xylulose kinase; Region: XylB; TIGR01312 941967001675 active site 941967001676 MgATP binding site [chemical binding]; other site 941967001677 catalytic site [active] 941967001678 metal binding site [ion binding]; metal-binding site 941967001679 xylulose binding site [chemical binding]; other site 941967001680 homodimer interface [polypeptide binding]; other site 941967001681 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 941967001682 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 941967001683 putative ligand binding site [chemical binding]; other site 941967001684 Helix-turn-helix domain; Region: HTH_18; pfam12833 941967001685 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941967001686 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 941967001687 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 941967001688 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 941967001689 NAD(P) binding site [chemical binding]; other site 941967001690 catalytic residues [active] 941967001691 choline dehydrogenase; Validated; Region: PRK02106 941967001692 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 941967001693 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 941967001694 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941967001695 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 941967001696 L-asparaginase II [Amino acid transport and metabolism]; Region: AnsA; COG4448 941967001697 transcription elongation factor regulatory protein; Validated; Region: PRK06342 941967001698 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 941967001699 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 941967001700 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 941967001701 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 941967001702 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 941967001703 Cl binding site [ion binding]; other site 941967001704 oligomer interface [polypeptide binding]; other site 941967001705 Transcriptional regulators [Transcription]; Region: FadR; COG2186 941967001706 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941967001707 DNA-binding site [nucleotide binding]; DNA binding site 941967001708 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 941967001709 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 941967001710 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941967001711 putative substrate translocation pore; other site 941967001712 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 941967001713 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 941967001714 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 941967001715 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 941967001716 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 941967001717 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941967001718 motif II; other site 941967001719 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 941967001720 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 941967001721 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 941967001722 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 941967001723 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 941967001724 Predicted transcriptional regulator [Transcription]; Region: COG4957 941967001725 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 941967001726 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 941967001727 DnaA box-binding interface [nucleotide binding]; other site 941967001728 amidase; Validated; Region: PRK05962 941967001729 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 941967001730 Flavin Reductases; Region: FlaRed; cl00801 941967001731 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 941967001732 putative active site [active] 941967001733 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941967001734 heme pocket [chemical binding]; other site 941967001735 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941967001736 dimer interface [polypeptide binding]; other site 941967001737 phosphorylation site [posttranslational modification] 941967001738 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941967001739 ATP binding site [chemical binding]; other site 941967001740 Mg2+ binding site [ion binding]; other site 941967001741 G-X-G motif; other site 941967001742 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 941967001743 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 941967001744 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 941967001745 Uncharacterized conserved protein [Function unknown]; Region: COG5447 941967001746 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330 941967001747 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 941967001748 Predicted integral membrane protein [Function unknown]; Region: COG5436 941967001749 Uncharacterized conserved protein [Function unknown]; Region: COG5402 941967001750 Transglycosylase; Region: Transgly; pfam00912 941967001751 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 941967001752 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 941967001753 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 941967001754 Uncharacterized conserved protein [Function unknown]; Region: COG5323 941967001755 Terminase-like family; Region: Terminase_6; pfam03237 941967001756 Phage-related protein [Function unknown]; Region: COG4695 941967001757 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 941967001758 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 941967001759 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 941967001760 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 941967001761 Phage capsid family; Region: Phage_capsid; pfam05065 941967001762 phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215 941967001763 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 941967001764 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 941967001765 oligomerization interface [polypeptide binding]; other site 941967001766 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 941967001767 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 941967001768 Predicted secreted protein [Function unknown]; Region: COG5437 941967001769 Protein of unknown function (DUF3356); Region: DUF3356; pfam11836 941967001770 Phage-related minor tail protein [Function unknown]; Region: COG5281 941967001771 TIGR02217 family protein; Region: chp_TIGR02217 941967001772 Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931 941967001773 phage conserved hypothetical protein BR0599; Region: phg_TIGR02218 941967001774 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 941967001775 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 941967001776 putative phage cell wall peptidase, NlpC/P60 family; Region: phage_NlpC_fam; TIGR02219 941967001777 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 941967001778 Putative phage tail protein; Region: Phage-tail_3; pfam13550 941967001779 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941967001780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941967001781 active site 941967001782 phosphorylation site [posttranslational modification] 941967001783 intermolecular recognition site; other site 941967001784 dimerization interface [polypeptide binding]; other site 941967001785 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941967001786 DNA binding site [nucleotide binding] 941967001787 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941967001788 HAMP domain; Region: HAMP; pfam00672 941967001789 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941967001790 ATP binding site [chemical binding]; other site 941967001791 Mg2+ binding site [ion binding]; other site 941967001792 G-X-G motif; other site 941967001793 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 941967001794 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 941967001795 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 941967001796 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 941967001797 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 941967001798 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 941967001799 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 941967001800 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 941967001801 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 941967001802 protein binding site [polypeptide binding]; other site 941967001803 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 941967001804 protein binding site [polypeptide binding]; other site 941967001805 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941967001806 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941967001807 active site 941967001808 phosphorylation site [posttranslational modification] 941967001809 intermolecular recognition site; other site 941967001810 dimerization interface [polypeptide binding]; other site 941967001811 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941967001812 DNA binding site [nucleotide binding] 941967001813 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941967001814 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 941967001815 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941967001816 dimerization interface [polypeptide binding]; other site 941967001817 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941967001818 dimer interface [polypeptide binding]; other site 941967001819 phosphorylation site [posttranslational modification] 941967001820 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941967001821 ATP binding site [chemical binding]; other site 941967001822 Mg2+ binding site [ion binding]; other site 941967001823 G-X-G motif; other site 941967001824 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 941967001825 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 941967001826 metal binding triad; other site 941967001827 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 941967001828 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 941967001829 metal binding triad; other site 941967001830 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 941967001831 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 941967001832 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298 941967001833 O-Antigen ligase; Region: Wzy_C; pfam04932 941967001834 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941967001835 PAS fold; Region: PAS_3; pfam08447 941967001836 putative active site [active] 941967001837 heme pocket [chemical binding]; other site 941967001838 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 941967001839 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941967001840 dimer interface [polypeptide binding]; other site 941967001841 phosphorylation site [posttranslational modification] 941967001842 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941967001843 ATP binding site [chemical binding]; other site 941967001844 Mg2+ binding site [ion binding]; other site 941967001845 G-X-G motif; other site 941967001846 aminopeptidase N; Provisional; Region: pepN; PRK14015 941967001847 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 941967001848 active site 941967001849 Zn binding site [ion binding]; other site 941967001850 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 941967001851 EamA-like transporter family; Region: EamA; pfam00892 941967001852 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941967001853 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941967001854 putative substrate translocation pore; other site 941967001855 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 941967001856 Fe-S cluster binding site [ion binding]; other site 941967001857 active site 941967001858 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 941967001859 hydroxyglutarate oxidase; Provisional; Region: PRK11728 941967001860 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 941967001861 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3021 941967001862 putative catalytic site [active] 941967001863 putative metal binding site [ion binding]; other site 941967001864 putative phosphate binding site [ion binding]; other site 941967001865 AMP nucleosidase; Provisional; Region: PRK08292 941967001866 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 941967001867 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 941967001868 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 941967001869 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 941967001870 C-terminal domain interface [polypeptide binding]; other site 941967001871 GSH binding site (G-site) [chemical binding]; other site 941967001872 dimer interface [polypeptide binding]; other site 941967001873 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 941967001874 N-terminal domain interface [polypeptide binding]; other site 941967001875 putative dimer interface [polypeptide binding]; other site 941967001876 active site 941967001877 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4731 941967001878 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 941967001879 Uncharacterized conserved protein [Function unknown]; Region: COG1284 941967001880 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 941967001881 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 941967001882 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 941967001883 histidinol-phosphate aminotransferase; Provisional; Region: PRK08153 941967001884 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941967001885 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941967001886 homodimer interface [polypeptide binding]; other site 941967001887 catalytic residue [active] 941967001888 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 941967001889 active site 941967001890 DNA binding site [nucleotide binding] 941967001891 Int/Topo IB signature motif; other site 941967001892 Porin subfamily; Region: Porin_2; pfam02530 941967001893 Porin subfamily; Region: Porin_2; pfam02530 941967001894 Uncharacterized conserved protein [Function unknown]; Region: COG3743 941967001895 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 941967001896 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 941967001897 N-acetyl-D-glucosamine binding site [chemical binding]; other site 941967001898 catalytic residue [active] 941967001899 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 941967001900 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 941967001901 dimer interface [polypeptide binding]; other site 941967001902 active site 941967001903 catalytic residue [active] 941967001904 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 941967001905 SmpB-tmRNA interface; other site 941967001906 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 941967001907 Fe-S cluster binding site [ion binding]; other site 941967001908 DNA binding site [nucleotide binding] 941967001909 active site 941967001910 Uncharacterized conserved protein [Function unknown]; Region: COG1432 941967001911 LabA_like proteins; Region: LabA; cd10911 941967001912 putative metal binding site [ion binding]; other site 941967001913 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 941967001914 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 941967001915 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 941967001916 Zn2+ binding site [ion binding]; other site 941967001917 Mg2+ binding site [ion binding]; other site 941967001918 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 941967001919 synthetase active site [active] 941967001920 NTP binding site [chemical binding]; other site 941967001921 metal binding site [ion binding]; metal-binding site 941967001922 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 941967001923 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 941967001924 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 941967001925 active site 941967001926 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 941967001927 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 941967001928 ligand binding site [chemical binding]; other site 941967001929 flexible hinge region; other site 941967001930 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 941967001931 putative switch regulator; other site 941967001932 non-specific DNA interactions [nucleotide binding]; other site 941967001933 DNA binding site [nucleotide binding] 941967001934 sequence specific DNA binding site [nucleotide binding]; other site 941967001935 putative cAMP binding site [chemical binding]; other site 941967001936 coproporphyrinogen III oxidase; Provisional; Region: PRK13347 941967001937 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941967001938 FeS/SAM binding site; other site 941967001939 HemN C-terminal domain; Region: HemN_C; pfam06969 941967001940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941967001941 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941967001942 putative substrate translocation pore; other site 941967001943 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 941967001944 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941967001945 Helix-turn-helix domain; Region: HTH_18; pfam12833 941967001946 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941967001947 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3216 941967001948 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 941967001949 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 941967001950 Catalytic site [active] 941967001951 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 941967001952 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 941967001953 ribonuclease III; Reviewed; Region: PRK12371 941967001954 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 941967001955 dimerization interface [polypeptide binding]; other site 941967001956 active site 941967001957 metal binding site [ion binding]; metal-binding site 941967001958 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 941967001959 dsRNA binding site [nucleotide binding]; other site 941967001960 GTPase Era; Reviewed; Region: era; PRK00089 941967001961 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 941967001962 G1 box; other site 941967001963 GTP/Mg2+ binding site [chemical binding]; other site 941967001964 Switch I region; other site 941967001965 G2 box; other site 941967001966 Switch II region; other site 941967001967 G3 box; other site 941967001968 G4 box; other site 941967001969 G5 box; other site 941967001970 KH domain; Region: KH_2; pfam07650 941967001971 Recombination protein O N terminal; Region: RecO_N; pfam11967 941967001972 DNA repair protein RecO; Region: reco; TIGR00613 941967001973 Recombination protein O C terminal; Region: RecO_C; pfam02565 941967001974 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 941967001975 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 941967001976 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 941967001977 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 941967001978 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 941967001979 dihydroorotase; Validated; Region: PRK09060 941967001980 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 941967001981 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 941967001982 active site 941967001983 Protein of unknown function (DUF2385); Region: DUF2385; cl11490 941967001984 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 941967001985 nudix motif; other site 941967001986 Uncharacterized conserved protein [Function unknown]; Region: COG2135 941967001987 Lysine efflux permease [General function prediction only]; Region: COG1279 941967001988 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 941967001989 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 941967001990 active site 941967001991 HIGH motif; other site 941967001992 nucleotide binding site [chemical binding]; other site 941967001993 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 941967001994 KMSKS motif; other site 941967001995 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 941967001996 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 941967001997 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 941967001998 active site 941967001999 catalytic residues [active] 941967002000 metal binding site [ion binding]; metal-binding site 941967002001 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 941967002002 Predicted permeases [General function prediction only]; Region: RarD; COG2962 941967002003 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 941967002004 Peptidase family M23; Region: Peptidase_M23; pfam01551 941967002005 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 941967002006 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941967002007 S-adenosylmethionine binding site [chemical binding]; other site 941967002008 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312 941967002009 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 941967002010 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 941967002011 SurA N-terminal domain; Region: SurA_N; pfam09312 941967002012 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 941967002013 OstA-like protein; Region: OstA; cl00844 941967002014 Organic solvent tolerance protein; Region: OstA_C; pfam04453 941967002015 Predicted permeases [General function prediction only]; Region: COG0795 941967002016 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 941967002017 Predicted permeases [General function prediction only]; Region: COG0795 941967002018 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 941967002019 multifunctional aminopeptidase A; Provisional; Region: PRK00913 941967002020 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 941967002021 interface (dimer of trimers) [polypeptide binding]; other site 941967002022 Substrate-binding/catalytic site; other site 941967002023 Zn-binding sites [ion binding]; other site 941967002024 DNA polymerase III subunit chi; Validated; Region: PRK05728 941967002025 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 941967002026 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 941967002027 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941967002028 Walker A/P-loop; other site 941967002029 ATP binding site [chemical binding]; other site 941967002030 ABC transporter signature motif; other site 941967002031 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 941967002032 Walker B; other site 941967002033 D-loop; other site 941967002034 ABC transporter; Region: ABC_tran_2; pfam12848 941967002035 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 941967002036 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 941967002037 DinB superfamily; Region: DinB_2; pfam12867 941967002038 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 941967002039 active site 941967002040 multimer interface [polypeptide binding]; other site 941967002041 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 941967002042 Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187 941967002043 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 941967002044 MoaE homodimer interface [polypeptide binding]; other site 941967002045 MoaD interaction [polypeptide binding]; other site 941967002046 active site residues [active] 941967002047 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 941967002048 MoaE interaction surface [polypeptide binding]; other site 941967002049 MoeB interaction surface [polypeptide binding]; other site 941967002050 thiocarboxylated glycine; other site 941967002051 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 941967002052 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 941967002053 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 941967002054 GIY-YIG motif/motif A; other site 941967002055 active site 941967002056 catalytic site [active] 941967002057 putative DNA binding site [nucleotide binding]; other site 941967002058 metal binding site [ion binding]; metal-binding site 941967002059 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 941967002060 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 941967002061 short chain dehydrogenase; Provisional; Region: PRK09134 941967002062 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 941967002063 NADP binding site [chemical binding]; other site 941967002064 substrate binding pocket [chemical binding]; other site 941967002065 active site 941967002066 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 941967002067 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 941967002068 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 941967002069 putative C-terminal domain interface [polypeptide binding]; other site 941967002070 putative GSH binding site (G-site) [chemical binding]; other site 941967002071 putative dimer interface [polypeptide binding]; other site 941967002072 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 941967002073 dimer interface [polypeptide binding]; other site 941967002074 N-terminal domain interface [polypeptide binding]; other site 941967002075 putative substrate binding pocket (H-site) [chemical binding]; other site 941967002076 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 941967002077 B1 nucleotide binding pocket [chemical binding]; other site 941967002078 B2 nucleotide binding pocket [chemical binding]; other site 941967002079 CAS motifs; other site 941967002080 active site 941967002081 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 941967002082 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 941967002083 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 941967002084 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 941967002085 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 941967002086 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 941967002087 putative molybdopterin cofactor binding site [chemical binding]; other site 941967002088 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 941967002089 putative molybdopterin cofactor binding site; other site 941967002090 Protein of unknown function (DUF992); Region: DUF992; pfam06186 941967002091 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 941967002092 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 941967002093 active site 941967002094 substrate binding site [chemical binding]; other site 941967002095 cosubstrate binding site; other site 941967002096 catalytic site [active] 941967002097 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 941967002098 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 941967002099 dimerization interface [polypeptide binding]; other site 941967002100 putative ATP binding site [chemical binding]; other site 941967002101 Domain of unknown function DUF20; Region: UPF0118; pfam01594 941967002102 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 941967002103 hypothetical protein; Validated; Region: PRK09087 941967002104 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 941967002105 Walker A motif; other site 941967002106 ATP binding site [chemical binding]; other site 941967002107 Walker B motif; other site 941967002108 arginine finger; other site 941967002109 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941967002110 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 941967002111 NAD(P) binding site [chemical binding]; other site 941967002112 active site 941967002113 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 941967002114 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 941967002115 putative NAD(P) binding site [chemical binding]; other site 941967002116 putative active site [active] 941967002117 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 941967002118 L-lactate permease; Region: Lactate_perm; cl00701 941967002119 L-lactate permease; Region: Lactate_perm; cl00701 941967002120 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 941967002121 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 941967002122 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 941967002123 active site 941967002124 catalytic site [active] 941967002125 substrate binding site [chemical binding]; other site 941967002126 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 941967002127 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 941967002128 Integrase core domain; Region: rve; pfam00665 941967002129 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 941967002130 Domain of unknown function (DUF955); Region: DUF955; pfam06114 941967002131 Uncharacterized protein containing a TIR (Toll-Interleukin 1-resistance) domain [Function unknown]; Region: COG4916 941967002132 TIR domain; Region: TIR_2; pfam13676 941967002133 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 941967002134 Bacterial SH3 domain; Region: SH3_3; pfam08239 941967002135 cystathionine beta-lyase; Provisional; Region: PRK05967 941967002136 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 941967002137 homodimer interface [polypeptide binding]; other site 941967002138 substrate-cofactor binding pocket; other site 941967002139 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941967002140 catalytic residue [active] 941967002141 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 941967002142 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 941967002143 active site 941967002144 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 941967002145 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941967002146 substrate binding pocket [chemical binding]; other site 941967002147 membrane-bound complex binding site; other site 941967002148 hinge residues; other site 941967002149 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 941967002150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967002151 conserved gate region; other site 941967002152 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967002153 putative PBP binding loops; other site 941967002154 dimer interface [polypeptide binding]; other site 941967002155 ABC-ATPase subunit interface; other site 941967002156 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 941967002157 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967002158 dimer interface [polypeptide binding]; other site 941967002159 conserved gate region; other site 941967002160 putative PBP binding loops; other site 941967002161 ABC-ATPase subunit interface; other site 941967002162 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 941967002163 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 941967002164 Walker A/P-loop; other site 941967002165 ATP binding site [chemical binding]; other site 941967002166 Q-loop/lid; other site 941967002167 ABC transporter signature motif; other site 941967002168 Walker B; other site 941967002169 D-loop; other site 941967002170 H-loop/switch region; other site 941967002171 salicylate hydroxylase; Provisional; Region: PRK06475 941967002172 salicylate hydroxylase; Provisional; Region: PRK08163 941967002173 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391 941967002174 polyphosphate kinase; Provisional; Region: PRK05443 941967002175 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 941967002176 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 941967002177 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 941967002178 putative domain interface [polypeptide binding]; other site 941967002179 putative active site [active] 941967002180 catalytic site [active] 941967002181 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 941967002182 putative domain interface [polypeptide binding]; other site 941967002183 putative active site [active] 941967002184 catalytic site [active] 941967002185 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 941967002186 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 941967002187 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 941967002188 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 941967002189 catalytic site [active] 941967002190 putative active site [active] 941967002191 putative substrate binding site [chemical binding]; other site 941967002192 HRDC domain; Region: HRDC; pfam00570 941967002193 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 941967002194 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 941967002195 dimer interface [polypeptide binding]; other site 941967002196 anticodon binding site; other site 941967002197 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 941967002198 homodimer interface [polypeptide binding]; other site 941967002199 motif 1; other site 941967002200 active site 941967002201 motif 2; other site 941967002202 GAD domain; Region: GAD; pfam02938 941967002203 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 941967002204 active site 941967002205 motif 3; other site 941967002206 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 941967002207 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 941967002208 CAP-like domain; other site 941967002209 active site 941967002210 primary dimer interface [polypeptide binding]; other site 941967002211 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 941967002212 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 941967002213 Putative arginyl-tRNA:protein arginylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG2935 941967002214 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 941967002215 Predicted membrane protein/domain [Function unknown]; Region: COG1714 941967002216 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 941967002217 dimer interface [polypeptide binding]; other site 941967002218 allosteric magnesium binding site [ion binding]; other site 941967002219 active site 941967002220 aspartate-rich active site metal binding site; other site 941967002221 Schiff base residues; other site 941967002222 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 941967002223 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 941967002224 substrate binding site [chemical binding]; other site 941967002225 oxyanion hole (OAH) forming residues; other site 941967002226 trimer interface [polypeptide binding]; other site 941967002227 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 941967002228 Transcriptional regulators [Transcription]; Region: MarR; COG1846 941967002229 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 941967002230 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 941967002231 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 941967002232 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 941967002233 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 941967002234 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 941967002235 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 941967002236 dimer interface [polypeptide binding]; other site 941967002237 active site 941967002238 glycine-pyridoxal phosphate binding site [chemical binding]; other site 941967002239 folate binding site [chemical binding]; other site 941967002240 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 941967002241 ATP cone domain; Region: ATP-cone; pfam03477 941967002242 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 941967002243 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 941967002244 catalytic motif [active] 941967002245 Zn binding site [ion binding]; other site 941967002246 RibD C-terminal domain; Region: RibD_C; cl17279 941967002247 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 941967002248 Lumazine binding domain; Region: Lum_binding; pfam00677 941967002249 Lumazine binding domain; Region: Lum_binding; pfam00677 941967002250 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 941967002251 homopentamer interface [polypeptide binding]; other site 941967002252 active site 941967002253 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 941967002254 putative RNA binding site [nucleotide binding]; other site 941967002255 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; COG3808 941967002256 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 941967002257 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 941967002258 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 941967002259 Uncharacterized conserved protein [Function unknown]; Region: COG5452 941967002260 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 941967002261 putative phosphate acyltransferase; Provisional; Region: PRK05331 941967002262 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 941967002263 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 941967002264 dimer interface [polypeptide binding]; other site 941967002265 active site 941967002266 CoA binding pocket [chemical binding]; other site 941967002267 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 941967002268 IHF - DNA interface [nucleotide binding]; other site 941967002269 IHF dimer interface [polypeptide binding]; other site 941967002270 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 941967002271 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 941967002272 DNA binding residues [nucleotide binding] 941967002273 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 941967002274 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 941967002275 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 941967002276 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 941967002277 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 941967002278 SLBB domain; Region: SLBB; pfam10531 941967002279 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 941967002280 Protein of unknown function (DUF2842); Region: DUF2842; pfam11003 941967002281 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 941967002282 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 941967002283 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 941967002284 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 941967002285 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 941967002286 oligomer interface [polypeptide binding]; other site 941967002287 putative active site [active] 941967002288 Mn binding site [ion binding]; other site 941967002289 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 941967002290 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 941967002291 23S rRNA interface [nucleotide binding]; other site 941967002292 L3 interface [polypeptide binding]; other site 941967002293 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 941967002294 CoenzymeA binding site [chemical binding]; other site 941967002295 subunit interaction site [polypeptide binding]; other site 941967002296 PHB binding site; other site 941967002297 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994 941967002298 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 941967002299 homodimer interface [polypeptide binding]; other site 941967002300 substrate-cofactor binding pocket; other site 941967002301 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941967002302 catalytic residue [active] 941967002303 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 941967002304 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 941967002305 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 941967002306 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 941967002307 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 941967002308 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 941967002309 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 941967002310 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 941967002311 NADH dehydrogenase subunit D; Validated; Region: PRK06075 941967002312 NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905 941967002313 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 941967002314 putative dimer interface [polypeptide binding]; other site 941967002315 [2Fe-2S] cluster binding site [ion binding]; other site 941967002316 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 941967002317 SLBB domain; Region: SLBB; pfam10531 941967002318 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 941967002319 NADH dehydrogenase subunit G; Validated; Region: PRK09130 941967002320 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 941967002321 catalytic loop [active] 941967002322 iron binding site [ion binding]; other site 941967002323 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 941967002324 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 941967002325 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 941967002326 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 941967002327 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 941967002328 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 941967002329 4Fe-4S binding domain; Region: Fer4; pfam00037 941967002330 4Fe-4S binding domain; Region: Fer4; pfam00037 941967002331 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 941967002332 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 941967002333 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 941967002334 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 941967002335 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 941967002336 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 941967002337 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 941967002338 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 941967002339 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 941967002340 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 941967002341 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 941967002342 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 941967002343 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 941967002344 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 941967002345 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 941967002346 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 941967002347 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 941967002348 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 941967002349 dimer interface [polypeptide binding]; other site 941967002350 substrate binding site [chemical binding]; other site 941967002351 metal binding site [ion binding]; metal-binding site 941967002352 Predicted secreted protein [Function unknown]; Region: COG5454 941967002353 prolyl-tRNA synthetase; Provisional; Region: PRK12325 941967002354 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 941967002355 dimer interface [polypeptide binding]; other site 941967002356 motif 1; other site 941967002357 active site 941967002358 motif 2; other site 941967002359 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 941967002360 active site 941967002361 motif 3; other site 941967002362 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 941967002363 anticodon binding site; other site 941967002364 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 941967002365 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 941967002366 FtsX-like permease family; Region: FtsX; pfam02687 941967002367 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 941967002368 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 941967002369 Walker A/P-loop; other site 941967002370 ATP binding site [chemical binding]; other site 941967002371 Q-loop/lid; other site 941967002372 ABC transporter signature motif; other site 941967002373 Walker B; other site 941967002374 D-loop; other site 941967002375 H-loop/switch region; other site 941967002376 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 941967002377 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 941967002378 putative active site [active] 941967002379 putative PHP Thumb interface [polypeptide binding]; other site 941967002380 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 941967002381 generic binding surface II; other site 941967002382 generic binding surface I; other site 941967002383 Protein of unknwon function (DUF3008); Region: DUF3008; pfam11450 941967002384 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 941967002385 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 941967002386 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 941967002387 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 941967002388 RNA binding surface [nucleotide binding]; other site 941967002389 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 941967002390 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 941967002391 Ligand Binding Site [chemical binding]; other site 941967002392 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 941967002393 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 941967002394 active site 941967002395 putative lithium-binding site [ion binding]; other site 941967002396 substrate binding site [chemical binding]; other site 941967002397 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 941967002398 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941967002399 putative substrate translocation pore; other site 941967002400 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 941967002401 putative GSH binding site [chemical binding]; other site 941967002402 catalytic residues [active] 941967002403 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 941967002404 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 941967002405 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 941967002406 dimerization interface [polypeptide binding]; other site 941967002407 ATP binding site [chemical binding]; other site 941967002408 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 941967002409 dimerization interface [polypeptide binding]; other site 941967002410 ATP binding site [chemical binding]; other site 941967002411 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 941967002412 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 941967002413 C-terminal domain interface [polypeptide binding]; other site 941967002414 GSH binding site (G-site) [chemical binding]; other site 941967002415 dimer interface [polypeptide binding]; other site 941967002416 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 941967002417 N-terminal domain interface [polypeptide binding]; other site 941967002418 dimer interface [polypeptide binding]; other site 941967002419 substrate binding pocket (H-site) [chemical binding]; other site 941967002420 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 941967002421 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 941967002422 putative active site [active] 941967002423 catalytic triad [active] 941967002424 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 941967002425 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 941967002426 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 941967002427 ATP binding site [chemical binding]; other site 941967002428 active site 941967002429 substrate binding site [chemical binding]; other site 941967002430 Uncharacterized conserved protein [Function unknown]; Region: COG5467 941967002431 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 941967002432 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 941967002433 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 941967002434 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 941967002435 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 941967002436 putative metal binding site [ion binding]; other site 941967002437 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 941967002438 active site 941967002439 adenylosuccinate lyase; Provisional; Region: PRK07492 941967002440 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 941967002441 tetramer interface [polypeptide binding]; other site 941967002442 active site 941967002443 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 941967002444 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 941967002445 substrate binding site [chemical binding]; other site 941967002446 hexamer interface [polypeptide binding]; other site 941967002447 metal binding site [ion binding]; metal-binding site 941967002448 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 941967002449 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 941967002450 putative acyl-acceptor binding pocket; other site 941967002451 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 941967002452 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266 941967002453 putative NAD(P) binding site [chemical binding]; other site 941967002454 structural Zn binding site [ion binding]; other site 941967002455 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501 941967002456 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 941967002457 dimer interface [polypeptide binding]; other site 941967002458 active site 941967002459 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519 941967002460 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 941967002461 active site 941967002462 acyl carrier protein; Provisional; Region: PRK06508 941967002463 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 941967002464 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 941967002465 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 941967002466 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 941967002467 active site 941967002468 catalytic residues [active] 941967002469 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 941967002470 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 941967002471 substrate binding site [chemical binding]; other site 941967002472 ATP binding site [chemical binding]; other site 941967002473 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 941967002474 Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454 941967002475 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 941967002476 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 941967002477 active site 941967002478 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 941967002479 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941967002480 active site 941967002481 motif I; other site 941967002482 motif II; other site 941967002483 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 941967002484 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941967002485 substrate binding pocket [chemical binding]; other site 941967002486 membrane-bound complex binding site; other site 941967002487 hinge residues; other site 941967002488 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 941967002489 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 941967002490 FMN binding site [chemical binding]; other site 941967002491 active site 941967002492 catalytic residues [active] 941967002493 substrate binding site [chemical binding]; other site 941967002494 Predicted aspartyl protease [General function prediction only]; Region: COG3577 941967002495 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 941967002496 catalytic motif [active] 941967002497 Catalytic residue [active] 941967002498 Predicted Fe-S protein [General function prediction only]; Region: COG3313 941967002499 cobalamin synthase; Reviewed; Region: cobS; PRK00235 941967002500 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 941967002501 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 941967002502 putative dimer interface [polypeptide binding]; other site 941967002503 active site pocket [active] 941967002504 putative cataytic base [active] 941967002505 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 941967002506 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 941967002507 putative DNA binding site [nucleotide binding]; other site 941967002508 putative Zn2+ binding site [ion binding]; other site 941967002509 AsnC family; Region: AsnC_trans_reg; pfam01037 941967002510 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 941967002511 putative uracil binding site [chemical binding]; other site 941967002512 putative active site [active] 941967002513 Staphylococcal nuclease homologues; Region: SNc; smart00318 941967002514 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 941967002515 Catalytic site; other site 941967002516 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 941967002517 Sel1-like repeats; Region: SEL1; smart00671 941967002518 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 941967002519 putative catalytic site [active] 941967002520 putative phosphate binding site [ion binding]; other site 941967002521 active site 941967002522 metal binding site A [ion binding]; metal-binding site 941967002523 DNA binding site [nucleotide binding] 941967002524 putative AP binding site [nucleotide binding]; other site 941967002525 putative metal binding site B [ion binding]; other site 941967002526 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 941967002527 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 941967002528 putative metal binding site [ion binding]; other site 941967002529 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 941967002530 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 941967002531 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 941967002532 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 941967002533 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 941967002534 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 941967002535 active site 941967002536 HIGH motif; other site 941967002537 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 941967002538 KMSK motif region; other site 941967002539 tRNA binding surface [nucleotide binding]; other site 941967002540 DALR anticodon binding domain; Region: DALR_1; smart00836 941967002541 anticodon binding site; other site 941967002542 Sporulation related domain; Region: SPOR; pfam05036 941967002543 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 941967002544 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 941967002545 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 941967002546 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 941967002547 twin arginine translocase protein A; Provisional; Region: tatA; PRK00720 941967002548 sec-independent translocase; Provisional; Region: PRK00708 941967002549 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 941967002550 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 941967002551 seryl-tRNA synthetase; Provisional; Region: PRK05431 941967002552 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 941967002553 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 941967002554 dimer interface [polypeptide binding]; other site 941967002555 active site 941967002556 motif 1; other site 941967002557 motif 2; other site 941967002558 motif 3; other site 941967002559 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 941967002560 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 941967002561 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941967002562 S-adenosylmethionine binding site [chemical binding]; other site 941967002563 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 941967002564 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 941967002565 Peptidase family M23; Region: Peptidase_M23; pfam01551 941967002566 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 941967002567 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941967002568 Walker A motif; other site 941967002569 ATP binding site [chemical binding]; other site 941967002570 Walker B motif; other site 941967002571 Preprotein translocase subunit YajC [Intracellular trafficking and secretion]; Region: YajC; COG1862 941967002572 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13023 941967002573 Protein export membrane protein; Region: SecD_SecF; cl14618 941967002574 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 941967002575 Protein export membrane protein; Region: SecD_SecF; pfam02355 941967002576 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 941967002577 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 941967002578 substrate binding pocket [chemical binding]; other site 941967002579 substrate-Mg2+ binding site; other site 941967002580 aspartate-rich region 1; other site 941967002581 aspartate-rich region 2; other site 941967002582 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 941967002583 Glucose inhibited division protein A; Region: GIDA; pfam01134 941967002584 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 941967002585 Predicted membrane protein [Function unknown]; Region: COG4872 941967002586 Uncharacterized membrane-anchored protein [Function unknown]; Region: COG4929 941967002587 trigger factor; Provisional; Region: tig; PRK01490 941967002588 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 941967002589 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 941967002590 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 941967002591 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 941967002592 GatB domain; Region: GatB_Yqey; smart00845 941967002593 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 941967002594 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 941967002595 Coenzyme A binding pocket [chemical binding]; other site 941967002596 NADH dehydrogenase; Validated; Region: PRK08183 941967002597 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4765 941967002598 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 941967002599 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 941967002600 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 941967002601 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 941967002602 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 941967002603 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 941967002604 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 941967002605 carboxyltransferase (CT) interaction site; other site 941967002606 biotinylation site [posttranslational modification]; other site 941967002607 Dehydroquinase class II; Region: DHquinase_II; pfam01220 941967002608 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 941967002609 trimer interface [polypeptide binding]; other site 941967002610 active site 941967002611 dimer interface [polypeptide binding]; other site 941967002612 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 941967002613 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 941967002614 catalytic residues [active] 941967002615 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 941967002616 Peptidase family M48; Region: Peptidase_M48; cl12018 941967002617 aspartate aminotransferase; Provisional; Region: PRK05764 941967002618 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941967002619 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941967002620 homodimer interface [polypeptide binding]; other site 941967002621 catalytic residue [active] 941967002622 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 941967002623 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 941967002624 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 941967002625 AMIN domain; Region: AMIN; pfam11741 941967002626 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 941967002627 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 941967002628 active site 941967002629 metal binding site [ion binding]; metal-binding site 941967002630 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 941967002631 Transglycosylase; Region: Transgly; pfam00912 941967002632 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 941967002633 peptide chain release factor 2; Provisional; Region: PRK07342 941967002634 This domain is found in peptide chain release factors; Region: PCRF; smart00937 941967002635 RF-1 domain; Region: RF-1; pfam00472 941967002636 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 941967002637 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 941967002638 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 941967002639 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 941967002640 dinuclear metal binding motif [ion binding]; other site 941967002641 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 941967002642 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 941967002643 catalytic triad [active] 941967002644 AsmA family; Region: AsmA; pfam05170 941967002645 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 941967002646 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 941967002647 active site 941967002648 HIGH motif; other site 941967002649 dimer interface [polypeptide binding]; other site 941967002650 KMSKS motif; other site 941967002651 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 941967002652 RNA binding surface [nucleotide binding]; other site 941967002653 Predicted molecular chaperone distantly related to HSP70-fold metalloproteases [Posttranslational modification, protein turnover, chaperones]; Region: COG2377 941967002654 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 941967002655 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 941967002656 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 941967002657 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 941967002658 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 941967002659 catalytic residue [active] 941967002660 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 941967002661 putative ABC transporter; Region: ycf24; CHL00085 941967002662 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 941967002663 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 941967002664 Walker A/P-loop; other site 941967002665 ATP binding site [chemical binding]; other site 941967002666 Q-loop/lid; other site 941967002667 ABC transporter signature motif; other site 941967002668 Walker B; other site 941967002669 D-loop; other site 941967002670 H-loop/switch region; other site 941967002671 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 941967002672 FeS assembly protein SufD; Region: sufD; TIGR01981 941967002673 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 941967002674 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 941967002675 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 941967002676 catalytic residue [active] 941967002677 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 941967002678 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 941967002679 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 941967002680 active site 941967002681 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 941967002682 ATP-NAD kinase; Region: NAD_kinase; pfam01513 941967002683 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 941967002684 helicase 45; Provisional; Region: PTZ00424 941967002685 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 941967002686 ATP binding site [chemical binding]; other site 941967002687 Mg++ binding site [ion binding]; other site 941967002688 motif III; other site 941967002689 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941967002690 nucleotide binding region [chemical binding]; other site 941967002691 ATP-binding site [chemical binding]; other site 941967002692 FeS assembly scaffold SufA; Region: sufA_proteo; TIGR01997 941967002693 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 941967002694 metal-binding site [ion binding] 941967002695 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 941967002696 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941967002697 S-adenosylmethionine binding site [chemical binding]; other site 941967002698 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 941967002699 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3827 941967002700 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 941967002701 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 941967002702 HIGH motif; other site 941967002703 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 941967002704 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 941967002705 active site 941967002706 KMSKS motif; other site 941967002707 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 941967002708 tRNA binding surface [nucleotide binding]; other site 941967002709 anticodon binding site; other site 941967002710 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 941967002711 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 941967002712 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 941967002713 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 941967002714 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 941967002715 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 941967002716 putative N-terminal domain interface [polypeptide binding]; other site 941967002717 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941967002718 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 941967002719 substrate binding pocket [chemical binding]; other site 941967002720 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 941967002721 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 941967002722 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 941967002723 GTP binding site; other site 941967002724 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 941967002725 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941967002726 FeS/SAM binding site; other site 941967002727 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 941967002728 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 941967002729 hypothetical protein; Provisional; Region: PRK06753 941967002730 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 941967002731 fumarate hydratase; Provisional; Region: PRK15389 941967002732 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 941967002733 Fumarase C-terminus; Region: Fumerase_C; pfam05683 941967002734 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 941967002735 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 941967002736 Transglycosylase associated protein; Region: Transgly_assoc; pfam04226 941967002737 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 941967002738 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 941967002739 active site 941967002740 Int/Topo IB signature motif; other site 941967002741 catalytic residues [active] 941967002742 DNA binding site [nucleotide binding] 941967002743 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 941967002744 Domain of unknown function (DUF4415); Region: DUF4415; cl01401 941967002745 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929 941967002746 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 941967002747 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 941967002748 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 941967002749 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 941967002750 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 941967002751 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 941967002752 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 941967002753 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 941967002754 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 941967002755 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 941967002756 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 941967002757 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 941967002758 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 941967002759 ArsC family; Region: ArsC; pfam03960 941967002760 catalytic residues [active] 941967002761 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 941967002762 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 941967002763 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 941967002764 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 941967002765 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 941967002766 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 941967002767 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 941967002768 TMP-binding site; other site 941967002769 ATP-binding site [chemical binding]; other site 941967002770 DNA polymerase III subunit delta'; Validated; Region: PRK09112 941967002771 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 941967002772 DNA polymerase III subunit delta'; Validated; Region: PRK08485 941967002773 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 941967002774 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 941967002775 active site 941967002776 HIGH motif; other site 941967002777 KMSKS motif; other site 941967002778 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 941967002779 tRNA binding surface [nucleotide binding]; other site 941967002780 anticodon binding site; other site 941967002781 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 941967002782 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 941967002783 active site 941967002784 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 941967002785 putative hydrolase; Provisional; Region: PRK02113 941967002786 cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657 941967002787 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 941967002788 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941967002789 Walker A/P-loop; other site 941967002790 ATP binding site [chemical binding]; other site 941967002791 Q-loop/lid; other site 941967002792 ABC transporter signature motif; other site 941967002793 Walker B; other site 941967002794 D-loop; other site 941967002795 H-loop/switch region; other site 941967002796 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 941967002797 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 941967002798 active site 941967002799 EamA-like transporter family; Region: EamA; pfam00892 941967002800 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 941967002801 EamA-like transporter family; Region: EamA; pfam00892 941967002802 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 941967002803 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 941967002804 motif I; other site 941967002805 active site 941967002806 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941967002807 motif II; other site 941967002808 Chaperone required for the assembly of the mitochondrial F1-ATPase [Posttranslational modification, protein turnover, chaperones]; Region: COG5387 941967002809 glutamine synthetase; Provisional; Region: glnA; PRK09469 941967002810 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 941967002811 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 941967002812 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 941967002813 Nitrogen regulatory protein P-II; Region: P-II; smart00938 941967002814 Uncharacterized conserved protein [Function unknown]; Region: COG0062 941967002815 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 941967002816 putative substrate binding site [chemical binding]; other site 941967002817 putative ATP binding site [chemical binding]; other site 941967002818 phosphoglycolate phosphatase; Provisional; Region: PRK13222 941967002819 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941967002820 motif II; other site 941967002821 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 941967002822 tetramer (dimer of dimers) interface [polypeptide binding]; other site 941967002823 active site 941967002824 dimer interface [polypeptide binding]; other site 941967002825 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3184 941967002826 glutathione reductase; Validated; Region: PRK06116 941967002827 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 941967002828 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 941967002829 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 941967002830 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 941967002831 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 941967002832 NAD synthetase; Provisional; Region: PRK13981 941967002833 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 941967002834 multimer interface [polypeptide binding]; other site 941967002835 active site 941967002836 catalytic triad [active] 941967002837 protein interface 1 [polypeptide binding]; other site 941967002838 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 941967002839 homodimer interface [polypeptide binding]; other site 941967002840 NAD binding pocket [chemical binding]; other site 941967002841 ATP binding pocket [chemical binding]; other site 941967002842 Mg binding site [ion binding]; other site 941967002843 active-site loop [active] 941967002844 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 941967002845 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 941967002846 active site 941967002847 HIGH motif; other site 941967002848 nucleotide binding site [chemical binding]; other site 941967002849 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 941967002850 active site 941967002851 KMSKS motif; other site 941967002852 malic enzyme; Reviewed; Region: PRK12862 941967002853 Malic enzyme, N-terminal domain; Region: malic; pfam00390 941967002854 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 941967002855 putative NAD(P) binding site [chemical binding]; other site 941967002856 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 941967002857 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 941967002858 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 941967002859 active site 941967002860 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 941967002861 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 941967002862 Permease; Region: Permease; pfam02405 941967002863 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 941967002864 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 941967002865 Walker A/P-loop; other site 941967002866 ATP binding site [chemical binding]; other site 941967002867 Q-loop/lid; other site 941967002868 ABC transporter signature motif; other site 941967002869 Walker B; other site 941967002870 D-loop; other site 941967002871 H-loop/switch region; other site 941967002872 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 941967002873 mce related protein; Region: MCE; pfam02470 941967002874 ABC-type uncharacterized transport system, auxiliary component [General function prediction only]; Region: COG3218 941967002875 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 941967002876 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 941967002877 chromosome segregation protein; Provisional; Region: PRK02224 941967002878 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 941967002879 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 941967002880 catalytic loop [active] 941967002881 iron binding site [ion binding]; other site 941967002882 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 941967002883 Predicted secreted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5661 941967002884 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 941967002885 dihydropteroate synthase; Region: DHPS; TIGR01496 941967002886 substrate binding pocket [chemical binding]; other site 941967002887 dimer interface [polypeptide binding]; other site 941967002888 inhibitor binding site; inhibition site 941967002889 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 941967002890 homooctamer interface [polypeptide binding]; other site 941967002891 active site 941967002892 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 941967002893 catalytic center binding site [active] 941967002894 ATP binding site [chemical binding]; other site 941967002895 Predicted membrane protein [Function unknown]; Region: COG3768 941967002896 Domain of unknown function (DUF697); Region: DUF697; cl12064 941967002897 YcjX-like family, DUF463; Region: DUF463; cl01193 941967002898 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 941967002899 catalytic core [active] 941967002900 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 941967002901 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 941967002902 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941967002903 PAS domain; Region: PAS_9; pfam13426 941967002904 putative active site [active] 941967002905 heme pocket [chemical binding]; other site 941967002906 PAS fold; Region: PAS_4; pfam08448 941967002907 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941967002908 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941967002909 dimer interface [polypeptide binding]; other site 941967002910 phosphorylation site [posttranslational modification] 941967002911 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941967002912 ATP binding site [chemical binding]; other site 941967002913 Mg2+ binding site [ion binding]; other site 941967002914 G-X-G motif; other site 941967002915 Response regulator receiver domain; Region: Response_reg; pfam00072 941967002916 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941967002917 active site 941967002918 phosphorylation site [posttranslational modification] 941967002919 intermolecular recognition site; other site 941967002920 dimerization interface [polypeptide binding]; other site 941967002921 Predicted flavoproteins [General function prediction only]; Region: COG2081 941967002922 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 941967002923 Beta-lactamase; Region: Beta-lactamase; pfam00144 941967002924 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 941967002925 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 941967002926 Mechanosensitive ion channel; Region: MS_channel; pfam00924 941967002927 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 941967002928 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 941967002929 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 941967002930 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 941967002931 active site 941967002932 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 941967002933 TSCPD domain; Region: TSCPD; pfam12637 941967002934 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 941967002935 nudix motif; other site 941967002936 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 941967002937 active site 941967002938 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 941967002939 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 941967002940 Ligand Binding Site [chemical binding]; other site 941967002941 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 941967002942 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 941967002943 putative MPT binding site; other site 941967002944 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 941967002945 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 941967002946 threonine dehydratase; Validated; Region: PRK08639 941967002947 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 941967002948 tetramer interface [polypeptide binding]; other site 941967002949 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941967002950 catalytic residue [active] 941967002951 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 941967002952 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 941967002953 DEAD-like helicases superfamily; Region: DEXDc; smart00487 941967002954 ATP binding site [chemical binding]; other site 941967002955 Mg++ binding site [ion binding]; other site 941967002956 motif III; other site 941967002957 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941967002958 nucleotide binding region [chemical binding]; other site 941967002959 ATP-binding site [chemical binding]; other site 941967002960 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 941967002961 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 941967002962 dimer interface [polypeptide binding]; other site 941967002963 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941967002964 catalytic residue [active] 941967002965 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 941967002966 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 941967002967 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 941967002968 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 941967002969 active site residue [active] 941967002970 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 941967002971 active site residue [active] 941967002972 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 941967002973 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941967002974 Coenzyme A binding pocket [chemical binding]; other site 941967002975 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941967002976 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941967002977 metal binding site [ion binding]; metal-binding site 941967002978 active site 941967002979 I-site; other site 941967002980 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 941967002981 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 941967002982 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 941967002983 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 941967002984 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941967002985 putative substrate translocation pore; other site 941967002986 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 941967002987 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 941967002988 HlyD family secretion protein; Region: HlyD_3; pfam13437 941967002989 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 941967002990 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 941967002991 putative NAD(P) binding site [chemical binding]; other site 941967002992 putative substrate binding site [chemical binding]; other site 941967002993 catalytic Zn binding site [ion binding]; other site 941967002994 structural Zn binding site [ion binding]; other site 941967002995 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 941967002996 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 941967002997 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 941967002998 active site 941967002999 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 941967003000 Tetratricopeptide repeat; Region: TPR_1; pfam00515 941967003001 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941967003002 S-adenosylmethionine binding site [chemical binding]; other site 941967003003 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 941967003004 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 941967003005 UDP-glucose 4-epimerase; Region: PLN02240 941967003006 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 941967003007 NAD binding site [chemical binding]; other site 941967003008 homodimer interface [polypeptide binding]; other site 941967003009 active site 941967003010 substrate binding site [chemical binding]; other site 941967003011 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 941967003012 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 941967003013 homodimer interface [polypeptide binding]; other site 941967003014 metal binding site [ion binding]; metal-binding site 941967003015 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 941967003016 homodimer interface [polypeptide binding]; other site 941967003017 active site 941967003018 putative chemical substrate binding site [chemical binding]; other site 941967003019 metal binding site [ion binding]; metal-binding site 941967003020 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 941967003021 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 941967003022 putative FMN binding site [chemical binding]; other site 941967003023 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 941967003024 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 941967003025 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 941967003026 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 941967003027 active site 941967003028 dimer interface [polypeptide binding]; other site 941967003029 motif 1; other site 941967003030 motif 2; other site 941967003031 motif 3; other site 941967003032 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 941967003033 anticodon binding site; other site 941967003034 Sporulation related domain; Region: SPOR; pfam05036 941967003035 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 941967003036 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 941967003037 hypothetical protein; Validated; Region: PRK00041 941967003038 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 941967003039 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 941967003040 trimerization site [polypeptide binding]; other site 941967003041 active site 941967003042 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 941967003043 homodecamer interface [polypeptide binding]; other site 941967003044 GTP cyclohydrolase I; Provisional; Region: PLN03044 941967003045 active site 941967003046 putative catalytic site residues [active] 941967003047 zinc binding site [ion binding]; other site 941967003048 GTP-CH-I/GFRP interaction surface; other site 941967003049 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 941967003050 hypothetical protein; Provisional; Region: PRK10279 941967003051 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 941967003052 nucleophile elbow; other site 941967003053 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 941967003054 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 941967003055 catalytic residues [active] 941967003056 catalytic nucleophile [active] 941967003057 Presynaptic Site I dimer interface [polypeptide binding]; other site 941967003058 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 941967003059 Synaptic Flat tetramer interface [polypeptide binding]; other site 941967003060 Synaptic Site I dimer interface [polypeptide binding]; other site 941967003061 DNA binding site [nucleotide binding] 941967003062 Prophage antirepressor [Transcription]; Region: COG3617 941967003063 BRO family, N-terminal domain; Region: Bro-N; smart01040 941967003064 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 941967003065 CoA-transferase family III; Region: CoA_transf_3; pfam02515 941967003066 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 941967003067 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 941967003068 FAD binding site [chemical binding]; other site 941967003069 substrate binding pocket [chemical binding]; other site 941967003070 catalytic base [active] 941967003071 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941967003072 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941967003073 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 941967003074 dimerization interface [polypeptide binding]; other site 941967003075 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 941967003076 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 941967003077 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 941967003078 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 941967003079 multidrug efflux protein; Reviewed; Region: PRK09579 941967003080 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 941967003081 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 941967003082 HlyD family secretion protein; Region: HlyD_3; pfam13437 941967003083 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941967003084 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941967003085 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 941967003086 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 941967003087 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 941967003088 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 941967003089 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 941967003090 active site 941967003091 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 941967003092 active site 941967003093 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 941967003094 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 941967003095 active site 941967003096 (T/H)XGH motif; other site 941967003097 DNA gyrase subunit A; Validated; Region: PRK05560 941967003098 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 941967003099 CAP-like domain; other site 941967003100 active site 941967003101 primary dimer interface [polypeptide binding]; other site 941967003102 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 941967003103 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 941967003104 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 941967003105 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 941967003106 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 941967003107 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 941967003108 Uncharacterized component of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3709 941967003109 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 941967003110 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941967003111 DNA-binding site [nucleotide binding]; DNA binding site 941967003112 UTRA domain; Region: UTRA; pfam07702 941967003113 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 941967003114 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 941967003115 dimer interface [polypeptide binding]; other site 941967003116 ssDNA binding site [nucleotide binding]; other site 941967003117 tetramer (dimer of dimers) interface [polypeptide binding]; other site 941967003118 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 941967003119 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 941967003120 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 941967003121 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 941967003122 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 941967003123 IHF dimer interface [polypeptide binding]; other site 941967003124 IHF - DNA interface [nucleotide binding]; other site 941967003125 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 941967003126 Found in ATP-dependent protease La (LON); Region: LON; smart00464 941967003127 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941967003128 Walker A motif; other site 941967003129 ATP binding site [chemical binding]; other site 941967003130 Walker B motif; other site 941967003131 arginine finger; other site 941967003132 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 941967003133 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 941967003134 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 941967003135 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941967003136 Walker A motif; other site 941967003137 ATP binding site [chemical binding]; other site 941967003138 Walker B motif; other site 941967003139 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 941967003140 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 941967003141 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 941967003142 oligomer interface [polypeptide binding]; other site 941967003143 active site residues [active] 941967003144 GTPases [General function prediction only]; Region: HflX; COG2262 941967003145 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 941967003146 HflX GTPase family; Region: HflX; cd01878 941967003147 G1 box; other site 941967003148 GTP/Mg2+ binding site [chemical binding]; other site 941967003149 Switch I region; other site 941967003150 G2 box; other site 941967003151 G3 box; other site 941967003152 Switch II region; other site 941967003153 G4 box; other site 941967003154 G5 box; other site 941967003155 bacterial Hfq-like; Region: Hfq; cd01716 941967003156 hexamer interface [polypeptide binding]; other site 941967003157 Sm1 motif; other site 941967003158 RNA binding site [nucleotide binding]; other site 941967003159 Sm2 motif; other site 941967003160 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 941967003161 TrkA-N domain; Region: TrkA_N; pfam02254 941967003162 TrkA-C domain; Region: TrkA_C; pfam02080 941967003163 TrkA-N domain; Region: TrkA_N; pfam02254 941967003164 TrkA-C domain; Region: TrkA_C; pfam02080 941967003165 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 941967003166 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941967003167 active site 941967003168 phosphorylation site [posttranslational modification] 941967003169 intermolecular recognition site; other site 941967003170 dimerization interface [polypeptide binding]; other site 941967003171 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941967003172 Walker A motif; other site 941967003173 ATP binding site [chemical binding]; other site 941967003174 Walker B motif; other site 941967003175 arginine finger; other site 941967003176 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 941967003177 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 941967003178 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941967003179 dimerization interface [polypeptide binding]; other site 941967003180 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941967003181 dimer interface [polypeptide binding]; other site 941967003182 phosphorylation site [posttranslational modification] 941967003183 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941967003184 ATP binding site [chemical binding]; other site 941967003185 Mg2+ binding site [ion binding]; other site 941967003186 G-X-G motif; other site 941967003187 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 941967003188 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941967003189 active site 941967003190 phosphorylation site [posttranslational modification] 941967003191 intermolecular recognition site; other site 941967003192 dimerization interface [polypeptide binding]; other site 941967003193 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941967003194 Walker A motif; other site 941967003195 ATP binding site [chemical binding]; other site 941967003196 Walker B motif; other site 941967003197 arginine finger; other site 941967003198 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 941967003199 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 941967003200 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941967003201 dimer interface [polypeptide binding]; other site 941967003202 phosphorylation site [posttranslational modification] 941967003203 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941967003204 ATP binding site [chemical binding]; other site 941967003205 Mg2+ binding site [ion binding]; other site 941967003206 G-X-G motif; other site 941967003207 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 941967003208 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 941967003209 FMN binding site [chemical binding]; other site 941967003210 active site 941967003211 catalytic residues [active] 941967003212 substrate binding site [chemical binding]; other site 941967003213 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 941967003214 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 941967003215 substrate binding site; other site 941967003216 dimer interface; other site 941967003217 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 941967003218 homotrimer interaction site [polypeptide binding]; other site 941967003219 zinc binding site [ion binding]; other site 941967003220 CDP-binding sites; other site 941967003221 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 941967003222 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 941967003223 classical (c) SDRs; Region: SDR_c; cd05233 941967003224 NAD(P) binding site [chemical binding]; other site 941967003225 active site 941967003226 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 941967003227 putative coenzyme Q binding site [chemical binding]; other site 941967003228 lipoyl synthase; Provisional; Region: PRK05481 941967003229 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941967003230 FeS/SAM binding site; other site 941967003231 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 941967003232 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 941967003233 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 941967003234 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 941967003235 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 941967003236 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 941967003237 E3 interaction surface; other site 941967003238 lipoyl attachment site [posttranslational modification]; other site 941967003239 e3 binding domain; Region: E3_binding; pfam02817 941967003240 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 941967003241 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 941967003242 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 941967003243 E3 interaction surface; other site 941967003244 lipoyl attachment site [posttranslational modification]; other site 941967003245 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 941967003246 alpha subunit interface [polypeptide binding]; other site 941967003247 TPP binding site [chemical binding]; other site 941967003248 heterodimer interface [polypeptide binding]; other site 941967003249 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 941967003250 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 941967003251 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 941967003252 tetramer interface [polypeptide binding]; other site 941967003253 TPP-binding site [chemical binding]; other site 941967003254 heterodimer interface [polypeptide binding]; other site 941967003255 phosphorylation loop region [posttranslational modification] 941967003256 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 941967003257 Septum formation initiator; Region: DivIC; pfam04977 941967003258 Methyltransferase domain; Region: Methyltransf_23; pfam13489 941967003259 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941967003260 S-adenosylmethionine binding site [chemical binding]; other site 941967003261 enolase; Provisional; Region: eno; PRK00077 941967003262 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 941967003263 dimer interface [polypeptide binding]; other site 941967003264 metal binding site [ion binding]; metal-binding site 941967003265 substrate binding pocket [chemical binding]; other site 941967003266 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 941967003267 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 941967003268 CTP synthetase; Validated; Region: pyrG; PRK05380 941967003269 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 941967003270 Catalytic site [active] 941967003271 active site 941967003272 UTP binding site [chemical binding]; other site 941967003273 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 941967003274 active site 941967003275 putative oxyanion hole; other site 941967003276 catalytic triad [active] 941967003277 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 941967003278 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 941967003279 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 941967003280 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 941967003281 triosephosphate isomerase; Provisional; Region: PRK14565 941967003282 substrate binding site [chemical binding]; other site 941967003283 dimer interface [polypeptide binding]; other site 941967003284 catalytic triad [active] 941967003285 SurA N-terminal domain; Region: SurA_N_3; cl07813 941967003286 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 941967003287 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 941967003288 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 941967003289 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 941967003290 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 941967003291 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 941967003292 active site 941967003293 ribulose/triose binding site [chemical binding]; other site 941967003294 phosphate binding site [ion binding]; other site 941967003295 substrate (anthranilate) binding pocket [chemical binding]; other site 941967003296 product (indole) binding pocket [chemical binding]; other site 941967003297 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 941967003298 trimer interface [polypeptide binding]; other site 941967003299 dimer interface [polypeptide binding]; other site 941967003300 putative active site [active] 941967003301 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 941967003302 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 941967003303 dimer interface [polypeptide binding]; other site 941967003304 putative functional site; other site 941967003305 putative MPT binding site; other site 941967003306 LexA repressor; Validated; Region: PRK00215 941967003307 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 941967003308 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 941967003309 Catalytic site [active] 941967003310 Competence protein; Region: Competence; pfam03772 941967003311 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 941967003312 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 941967003313 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 941967003314 active site 941967003315 HIGH motif; other site 941967003316 nucleotide binding site [chemical binding]; other site 941967003317 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 941967003318 active site 941967003319 KMSKS motif; other site 941967003320 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 941967003321 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 941967003322 dimer interface [polypeptide binding]; other site 941967003323 active site 941967003324 citrylCoA binding site [chemical binding]; other site 941967003325 NADH binding [chemical binding]; other site 941967003326 cationic pore residues; other site 941967003327 oxalacetate/citrate binding site [chemical binding]; other site 941967003328 coenzyme A binding site [chemical binding]; other site 941967003329 catalytic triad [active] 941967003330 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 941967003331 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 941967003332 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3494 941967003333 Acyl-[acyl carrier protein]; Region: LpxA; COG1043 941967003334 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 941967003335 active site 941967003336 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 941967003337 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 941967003338 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 941967003339 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 941967003340 trimer interface [polypeptide binding]; other site 941967003341 active site 941967003342 UDP-GlcNAc binding site [chemical binding]; other site 941967003343 lipid binding site [chemical binding]; lipid-binding site 941967003344 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 941967003345 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 941967003346 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 941967003347 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 941967003348 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 941967003349 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 941967003350 Surface antigen; Region: Bac_surface_Ag; pfam01103 941967003351 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 941967003352 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 941967003353 active site 941967003354 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 941967003355 protein binding site [polypeptide binding]; other site 941967003356 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 941967003357 putative substrate binding region [chemical binding]; other site 941967003358 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 941967003359 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 941967003360 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834 941967003361 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 941967003362 catalytic residue [active] 941967003363 putative FPP diphosphate binding site; other site 941967003364 putative FPP binding hydrophobic cleft; other site 941967003365 dimer interface [polypeptide binding]; other site 941967003366 putative IPP diphosphate binding site; other site 941967003367 ribosome recycling factor; Reviewed; Region: frr; PRK00083 941967003368 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 941967003369 hinge region; other site 941967003370 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 941967003371 putative nucleotide binding site [chemical binding]; other site 941967003372 uridine monophosphate binding site [chemical binding]; other site 941967003373 homohexameric interface [polypeptide binding]; other site 941967003374 elongation factor Ts; Provisional; Region: tsf; PRK09377 941967003375 UBA/TS-N domain; Region: UBA; pfam00627 941967003376 Elongation factor TS; Region: EF_TS; pfam00889 941967003377 Elongation factor TS; Region: EF_TS; pfam00889 941967003378 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 941967003379 rRNA interaction site [nucleotide binding]; other site 941967003380 S8 interaction site; other site 941967003381 putative laminin-1 binding site; other site 941967003382 Uncharacterized protein conserved in bacteria with a cystatin-like fold [Function unknown]; Region: COG4875 941967003383 SnoaL-like domain; Region: SnoaL_3; pfam13474 941967003384 Domain of unknown function (DUF1849); Region: DUF1849; pfam08904 941967003385 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 941967003386 homotrimer interaction site [polypeptide binding]; other site 941967003387 putative active site [active] 941967003388 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_3; cd08585 941967003389 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 941967003390 putative active site [active] 941967003391 catalytic site [active] 941967003392 putative metal binding site [ion binding]; other site 941967003393 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146 941967003394 Protein of unknown function, DUF482; Region: DUF482; pfam04339 941967003395 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 941967003396 HIT family signature motif; other site 941967003397 catalytic residue [active] 941967003398 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 941967003399 Clp amino terminal domain; Region: Clp_N; pfam02861 941967003400 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941967003401 Walker A motif; other site 941967003402 ATP binding site [chemical binding]; other site 941967003403 Walker B motif; other site 941967003404 arginine finger; other site 941967003405 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941967003406 Walker A motif; other site 941967003407 ATP binding site [chemical binding]; other site 941967003408 Walker B motif; other site 941967003409 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 941967003410 Uncharacterized conserved protein [Function unknown]; Region: COG2127 941967003411 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 941967003412 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 941967003413 Sporulation related domain; Region: SPOR; pfam05036 941967003414 Uncharacterized conserved protein [Function unknown]; Region: COG5458 941967003415 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 941967003416 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 941967003417 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 941967003418 Uncharacterized conserved protein [Function unknown]; Region: COG1434 941967003419 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 941967003420 putative active site [active] 941967003421 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 941967003422 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 941967003423 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 941967003424 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 941967003425 DNA binding residues [nucleotide binding] 941967003426 putative dimer interface [polypeptide binding]; other site 941967003427 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 941967003428 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 941967003429 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3803 941967003430 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 941967003431 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941967003432 non-specific DNA binding site [nucleotide binding]; other site 941967003433 salt bridge; other site 941967003434 sequence-specific DNA binding site [nucleotide binding]; other site 941967003435 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 941967003436 Domain of unknown function (DUF955); Region: DUF955; pfam06114 941967003437 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 941967003438 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 941967003439 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 941967003440 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 941967003441 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 941967003442 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 941967003443 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 941967003444 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 941967003445 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 941967003446 carboxyltransferase (CT) interaction site; other site 941967003447 biotinylation site [posttranslational modification]; other site 941967003448 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 941967003449 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 941967003450 active site 941967003451 substrate binding site [chemical binding]; other site 941967003452 coenzyme B12 binding site [chemical binding]; other site 941967003453 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 941967003454 B12 binding site [chemical binding]; other site 941967003455 cobalt ligand [ion binding]; other site 941967003456 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 941967003457 DctM-like transporters; Region: DctM; pfam06808 941967003458 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 941967003459 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 941967003460 glutamate racemase; Provisional; Region: PRK00865 941967003461 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 941967003462 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 941967003463 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 941967003464 intracellular protease, PfpI family; Region: PfpI; TIGR01382 941967003465 conserved cys residue [active] 941967003466 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 941967003467 isocitrate dehydrogenase; Validated; Region: PRK08299 941967003468 alkaline phosphatase; Provisional; Region: PRK10518 941967003469 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 941967003470 dimer interface [polypeptide binding]; other site 941967003471 active site 941967003472 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 941967003473 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 941967003474 motif 1; other site 941967003475 active site 941967003476 motif 2; other site 941967003477 motif 3; other site 941967003478 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 941967003479 recombinase A; Provisional; Region: recA; PRK09354 941967003480 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 941967003481 hexamer interface [polypeptide binding]; other site 941967003482 Walker A motif; other site 941967003483 ATP binding site [chemical binding]; other site 941967003484 Walker B motif; other site 941967003485 putative outer membrane lipoprotein; Provisional; Region: PRK10510 941967003486 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 941967003487 ligand binding site [chemical binding]; other site 941967003488 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 941967003489 N-acetyl-D-glucosamine binding site [chemical binding]; other site 941967003490 catalytic residue [active] 941967003491 recombination factor protein RarA; Reviewed; Region: PRK13342 941967003492 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941967003493 Walker A motif; other site 941967003494 ATP binding site [chemical binding]; other site 941967003495 Walker B motif; other site 941967003496 arginine finger; other site 941967003497 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 941967003498 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 941967003499 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 941967003500 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 941967003501 protein binding site [polypeptide binding]; other site 941967003502 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 941967003503 protein binding site [polypeptide binding]; other site 941967003504 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 941967003505 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 941967003506 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 941967003507 alphaNTD homodimer interface [polypeptide binding]; other site 941967003508 alphaNTD - beta interaction site [polypeptide binding]; other site 941967003509 alphaNTD - beta' interaction site [polypeptide binding]; other site 941967003510 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 941967003511 30S ribosomal protein S11; Validated; Region: PRK05309 941967003512 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 941967003513 30S ribosomal protein S13; Region: bact_S13; TIGR03631 941967003514 adenylate kinase; Reviewed; Region: adk; PRK00279 941967003515 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 941967003516 AMP-binding site [chemical binding]; other site 941967003517 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 941967003518 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 941967003519 SecY translocase; Region: SecY; pfam00344 941967003520 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 941967003521 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 941967003522 23S rRNA binding site [nucleotide binding]; other site 941967003523 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 941967003524 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 941967003525 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 941967003526 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 941967003527 5S rRNA interface [nucleotide binding]; other site 941967003528 23S rRNA interface [nucleotide binding]; other site 941967003529 L5 interface [polypeptide binding]; other site 941967003530 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 941967003531 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 941967003532 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 941967003533 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 941967003534 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 941967003535 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 941967003536 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 941967003537 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 941967003538 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 941967003539 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 941967003540 RNA binding site [nucleotide binding]; other site 941967003541 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 941967003542 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 941967003543 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 941967003544 23S rRNA interface [nucleotide binding]; other site 941967003545 putative translocon interaction site; other site 941967003546 signal recognition particle (SRP54) interaction site; other site 941967003547 L23 interface [polypeptide binding]; other site 941967003548 trigger factor interaction site; other site 941967003549 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 941967003550 23S rRNA interface [nucleotide binding]; other site 941967003551 5S rRNA interface [nucleotide binding]; other site 941967003552 putative antibiotic binding site [chemical binding]; other site 941967003553 L25 interface [polypeptide binding]; other site 941967003554 L27 interface [polypeptide binding]; other site 941967003555 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 941967003556 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 941967003557 G-X-X-G motif; other site 941967003558 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 941967003559 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 941967003560 putative translocon binding site; other site 941967003561 protein-rRNA interface [nucleotide binding]; other site 941967003562 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 941967003563 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 941967003564 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 941967003565 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 941967003566 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 941967003567 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 941967003568 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 941967003569 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 941967003570 elongation factor Tu; Reviewed; Region: PRK00049 941967003571 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 941967003572 G1 box; other site 941967003573 GEF interaction site [polypeptide binding]; other site 941967003574 GTP/Mg2+ binding site [chemical binding]; other site 941967003575 Switch I region; other site 941967003576 G2 box; other site 941967003577 G3 box; other site 941967003578 Switch II region; other site 941967003579 G4 box; other site 941967003580 G5 box; other site 941967003581 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 941967003582 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 941967003583 Antibiotic Binding Site [chemical binding]; other site 941967003584 elongation factor G; Reviewed; Region: PRK00007 941967003585 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 941967003586 G1 box; other site 941967003587 putative GEF interaction site [polypeptide binding]; other site 941967003588 GTP/Mg2+ binding site [chemical binding]; other site 941967003589 Switch I region; other site 941967003590 G2 box; other site 941967003591 G3 box; other site 941967003592 Switch II region; other site 941967003593 G4 box; other site 941967003594 G5 box; other site 941967003595 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 941967003596 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 941967003597 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 941967003598 30S ribosomal protein S7; Validated; Region: PRK05302 941967003599 Ribosomal protein S12-like family; composed of prokaryotic 30S ribosomal protein S12, eukaryotic 40S ribosomal protein S23 and similar proteins. S12 and S23 are located at the interface of the large and small ribosomal subunits, adjacent to the decoding...; Region: Ribosomal_S12_like; cl00312 941967003600 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 941967003601 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 941967003602 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 941967003603 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 941967003604 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 941967003605 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 941967003606 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 941967003607 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 941967003608 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 941967003609 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 941967003610 DNA binding site [nucleotide binding] 941967003611 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 941967003612 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 941967003613 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 941967003614 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 941967003615 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 941967003616 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 941967003617 RPB11 interaction site [polypeptide binding]; other site 941967003618 RPB12 interaction site [polypeptide binding]; other site 941967003619 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 941967003620 RPB1 interaction site [polypeptide binding]; other site 941967003621 RPB11 interaction site [polypeptide binding]; other site 941967003622 RPB10 interaction site [polypeptide binding]; other site 941967003623 RPB3 interaction site [polypeptide binding]; other site 941967003624 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 941967003625 L11 interface [polypeptide binding]; other site 941967003626 putative EF-Tu interaction site [polypeptide binding]; other site 941967003627 putative EF-G interaction site [polypeptide binding]; other site 941967003628 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 941967003629 23S rRNA interface [nucleotide binding]; other site 941967003630 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 941967003631 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 941967003632 mRNA/rRNA interface [nucleotide binding]; other site 941967003633 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 941967003634 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 941967003635 23S rRNA interface [nucleotide binding]; other site 941967003636 L7/L12 interface [polypeptide binding]; other site 941967003637 putative thiostrepton binding site; other site 941967003638 L25 interface [polypeptide binding]; other site 941967003639 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 941967003640 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 941967003641 putative homodimer interface [polypeptide binding]; other site 941967003642 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 941967003643 heterodimer interface [polypeptide binding]; other site 941967003644 homodimer interface [polypeptide binding]; other site 941967003645 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 941967003646 elongation factor Tu; Reviewed; Region: PRK00049 941967003647 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 941967003648 G1 box; other site 941967003649 GEF interaction site [polypeptide binding]; other site 941967003650 GTP/Mg2+ binding site [chemical binding]; other site 941967003651 Switch I region; other site 941967003652 G2 box; other site 941967003653 G3 box; other site 941967003654 Switch II region; other site 941967003655 G4 box; other site 941967003656 G5 box; other site 941967003657 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 941967003658 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 941967003659 Antibiotic Binding Site [chemical binding]; other site 941967003660 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 941967003661 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 941967003662 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 941967003663 FOG: CBS domain [General function prediction only]; Region: COG0517 941967003664 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 941967003665 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 941967003666 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 941967003667 PAS domain; Region: PAS_5; pfam07310 941967003668 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 941967003669 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 941967003670 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 941967003671 trimer interface [polypeptide binding]; other site 941967003672 putative metal binding site [ion binding]; other site 941967003673 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 941967003674 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 941967003675 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 941967003676 Protein of unknown function (DUF3126); Region: DUF3126; pfam11324 941967003677 serine acetyltransferase; Provisional; Region: cysE; PRK11132 941967003678 Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971 941967003679 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 941967003680 trimer interface [polypeptide binding]; other site 941967003681 active site 941967003682 substrate binding site [chemical binding]; other site 941967003683 CoA binding site [chemical binding]; other site 941967003684 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 941967003685 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 941967003686 Uncharacterized conserved protein [Function unknown]; Region: COG1430 941967003687 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 941967003688 DNA-binding site [nucleotide binding]; DNA binding site 941967003689 RNA-binding motif; other site 941967003690 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 941967003691 DNA-binding site [nucleotide binding]; DNA binding site 941967003692 RNA-binding motif; other site 941967003693 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 941967003694 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 941967003695 dimer interface [polypeptide binding]; other site 941967003696 active site 941967003697 metal binding site [ion binding]; metal-binding site 941967003698 glutathione binding site [chemical binding]; other site 941967003699 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 941967003700 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 941967003701 DHH family; Region: DHH; pfam01368 941967003702 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 941967003703 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 941967003704 ATP-grasp domain; Region: ATP-grasp_4; cl17255 941967003705 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 941967003706 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 941967003707 putative active site [active] 941967003708 homoserine dehydrogenase; Provisional; Region: PRK06349 941967003709 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 941967003710 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 941967003711 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 941967003712 aminotransferase; Validated; Region: PRK09148 941967003713 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941967003714 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941967003715 homodimer interface [polypeptide binding]; other site 941967003716 catalytic residue [active] 941967003717 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 941967003718 Peptidase M15; Region: Peptidase_M15_3; cl01194 941967003719 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3553 941967003720 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 941967003721 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 941967003722 active site 941967003723 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 941967003724 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 941967003725 MPN+ (JAMM) motif; other site 941967003726 Zinc-binding site [ion binding]; other site 941967003727 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 941967003728 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 941967003729 active site 941967003730 SAM binding site [chemical binding]; other site 941967003731 putative homodimer interface [polypeptide binding]; other site 941967003732 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 941967003733 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941967003734 S-adenosylmethionine binding site [chemical binding]; other site 941967003735 precorrin-3B synthase; Region: CobG; TIGR02435 941967003736 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 941967003737 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 941967003738 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 941967003739 Precorrin-8X methylmutase; Region: CbiC; pfam02570 941967003740 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 941967003741 active site 941967003742 SAM binding site [chemical binding]; other site 941967003743 homodimer interface [polypeptide binding]; other site 941967003744 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 941967003745 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 941967003746 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 941967003747 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 941967003748 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 941967003749 active site 941967003750 SAM binding site [chemical binding]; other site 941967003751 homodimer interface [polypeptide binding]; other site 941967003752 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 941967003753 TIGR02099 family protein; Region: TIGR02099 941967003754 Flavin Reductases; Region: FlaRed; cl00801 941967003755 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 941967003756 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 941967003757 ligand binding site [chemical binding]; other site 941967003758 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 941967003759 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 941967003760 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 941967003761 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941967003762 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941967003763 homodimer interface [polypeptide binding]; other site 941967003764 catalytic residue [active] 941967003765 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 941967003766 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 941967003767 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 941967003768 active site 941967003769 SAM binding site [chemical binding]; other site 941967003770 homodimer interface [polypeptide binding]; other site 941967003771 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 941967003772 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 941967003773 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 941967003774 active site 941967003775 SAM binding site [chemical binding]; other site 941967003776 homodimer interface [polypeptide binding]; other site 941967003777 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 941967003778 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 941967003779 tellurium resistance terB-like protein; Region: terB_like; cd07177 941967003780 metal binding site [ion binding]; metal-binding site 941967003781 hypothetical protein; Provisional; Region: PRK10621 941967003782 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 941967003783 Predicted membrane protein [Function unknown]; Region: COG2510 941967003784 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 941967003785 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 941967003786 homodimer interface [polypeptide binding]; other site 941967003787 Walker A motif; other site 941967003788 ATP binding site [chemical binding]; other site 941967003789 hydroxycobalamin binding site [chemical binding]; other site 941967003790 Walker B motif; other site 941967003791 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 941967003792 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 941967003793 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 941967003794 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 941967003795 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 941967003796 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 941967003797 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 941967003798 homotrimer interface [polypeptide binding]; other site 941967003799 Walker A motif; other site 941967003800 GTP binding site [chemical binding]; other site 941967003801 Walker B motif; other site 941967003802 Predicted integral membrane protein [Function unknown]; Region: COG5446 941967003803 cobalt transporter subunit CbtB (proposed); Region: CbtB; TIGR02459 941967003804 cobyric acid synthase; Provisional; Region: PRK00784 941967003805 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 941967003806 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 941967003807 catalytic triad [active] 941967003808 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 941967003809 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 941967003810 substrate binding pocket [chemical binding]; other site 941967003811 FAD binding site [chemical binding]; other site 941967003812 catalytic base [active] 941967003813 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 941967003814 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 941967003815 Predicted small secreted protein [Function unknown]; Region: COG5510 941967003816 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941967003817 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941967003818 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 941967003819 dimerization interface [polypeptide binding]; other site 941967003820 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 941967003821 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 941967003822 conserved cys residue [active] 941967003823 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941967003824 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941967003825 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 941967003826 hydroxyglutarate oxidase; Provisional; Region: PRK11728 941967003827 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 941967003828 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 941967003829 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 941967003830 Mechanosensitive ion channel; Region: MS_channel; pfam00924 941967003831 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 941967003832 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 941967003833 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 941967003834 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 941967003835 Protein export membrane protein; Region: SecD_SecF; pfam02355 941967003836 putative cation:proton antiport protein; Provisional; Region: PRK10669 941967003837 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 941967003838 TrkA-N domain; Region: TrkA_N; pfam02254 941967003839 Predicted integral membrane protein [Function unknown]; Region: COG0392 941967003840 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 941967003841 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 941967003842 sulfate transport protein; Provisional; Region: cysT; CHL00187 941967003843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967003844 dimer interface [polypeptide binding]; other site 941967003845 conserved gate region; other site 941967003846 putative PBP binding loops; other site 941967003847 ABC-ATPase subunit interface; other site 941967003848 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 941967003849 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967003850 dimer interface [polypeptide binding]; other site 941967003851 conserved gate region; other site 941967003852 putative PBP binding loops; other site 941967003853 ABC-ATPase subunit interface; other site 941967003854 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 941967003855 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 941967003856 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 941967003857 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 941967003858 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 941967003859 Transporter associated domain; Region: CorC_HlyC; smart01091 941967003860 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 941967003861 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 941967003862 Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154 941967003863 short chain dehydrogenase; Provisional; Region: PRK06198 941967003864 classical (c) SDRs; Region: SDR_c; cd05233 941967003865 NAD(P) binding site [chemical binding]; other site 941967003866 active site 941967003867 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 941967003868 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 941967003869 Walker A/P-loop; other site 941967003870 ATP binding site [chemical binding]; other site 941967003871 Q-loop/lid; other site 941967003872 ABC transporter signature motif; other site 941967003873 Walker B; other site 941967003874 D-loop; other site 941967003875 H-loop/switch region; other site 941967003876 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 941967003877 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 941967003878 TM-ABC transporter signature motif; other site 941967003879 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 941967003880 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 941967003881 putative ligand binding site [chemical binding]; other site 941967003882 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 941967003883 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 941967003884 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 941967003885 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 941967003886 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 941967003887 Walker A/P-loop; other site 941967003888 ATP binding site [chemical binding]; other site 941967003889 Q-loop/lid; other site 941967003890 ABC transporter signature motif; other site 941967003891 Walker B; other site 941967003892 D-loop; other site 941967003893 H-loop/switch region; other site 941967003894 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 941967003895 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 941967003896 ABC-ATPase subunit interface; other site 941967003897 dimer interface [polypeptide binding]; other site 941967003898 putative PBP binding regions; other site 941967003899 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 941967003900 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 941967003901 intersubunit interface [polypeptide binding]; other site 941967003902 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 941967003903 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 941967003904 N-terminal plug; other site 941967003905 ligand-binding site [chemical binding]; other site 941967003906 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 941967003907 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 941967003908 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 941967003909 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 941967003910 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 941967003911 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 941967003912 Walker A/P-loop; other site 941967003913 ATP binding site [chemical binding]; other site 941967003914 Q-loop/lid; other site 941967003915 ABC transporter signature motif; other site 941967003916 Walker B; other site 941967003917 D-loop; other site 941967003918 H-loop/switch region; other site 941967003919 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 941967003920 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 941967003921 Walker A/P-loop; other site 941967003922 ATP binding site [chemical binding]; other site 941967003923 Q-loop/lid; other site 941967003924 ABC transporter signature motif; other site 941967003925 Walker B; other site 941967003926 D-loop; other site 941967003927 H-loop/switch region; other site 941967003928 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 941967003929 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 941967003930 HlyD family secretion protein; Region: HlyD_3; pfam13437 941967003931 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 941967003932 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 941967003933 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 941967003934 alpha-gamma subunit interface [polypeptide binding]; other site 941967003935 beta-gamma subunit interface [polypeptide binding]; other site 941967003936 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 941967003937 alpha-beta subunit interface [polypeptide binding]; other site 941967003938 urease subunit alpha; Reviewed; Region: ureC; PRK13309 941967003939 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 941967003940 subunit interactions [polypeptide binding]; other site 941967003941 active site 941967003942 flap region; other site 941967003943 urease accessory protein UreE; Provisional; Region: ureE; PRK14711 941967003944 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 941967003945 dimer interface [polypeptide binding]; other site 941967003946 catalytic residues [active] 941967003947 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 941967003948 UreF; Region: UreF; pfam01730 941967003949 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 941967003950 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 941967003951 Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413 941967003952 ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266 941967003953 cobalt transport protein CbiM; Validated; Region: PRK06265 941967003954 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 941967003955 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 941967003956 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 941967003957 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 941967003958 Walker A/P-loop; other site 941967003959 ATP binding site [chemical binding]; other site 941967003960 Q-loop/lid; other site 941967003961 ABC transporter signature motif; other site 941967003962 Walker B; other site 941967003963 D-loop; other site 941967003964 H-loop/switch region; other site 941967003965 camphor resistance protein CrcB; Provisional; Region: ccrB; PRK01636 941967003966 Uncharacterized conserved protein [Function unknown]; Region: COG3439 941967003967 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 941967003968 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 941967003969 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 941967003970 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 941967003971 nudix motif; other site 941967003972 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 941967003973 putative catalytic site [active] 941967003974 putative metal binding site [ion binding]; other site 941967003975 putative phosphate binding site [ion binding]; other site 941967003976 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 941967003977 putative metal binding site [ion binding]; other site 941967003978 BA14K-like protein; Region: BA14K; pfam07886 941967003979 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 941967003980 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941967003981 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941967003982 homodimer interface [polypeptide binding]; other site 941967003983 catalytic residue [active] 941967003984 ketol-acid reductoisomerase; Provisional; Region: PRK05479 941967003985 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 941967003986 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 941967003987 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941967003988 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941967003989 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 941967003990 potassium uptake protein; Region: kup; TIGR00794 941967003991 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 941967003992 active site 941967003993 hydrophilic channel; other site 941967003994 dimerization interface [polypeptide binding]; other site 941967003995 catalytic residues [active] 941967003996 active site lid [active] 941967003997 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 941967003998 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 941967003999 AAA domain; Region: AAA_30; pfam13604 941967004000 Family description; Region: UvrD_C_2; pfam13538 941967004001 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 941967004002 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 941967004003 putative valine binding site [chemical binding]; other site 941967004004 dimer interface [polypeptide binding]; other site 941967004005 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 941967004006 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 941967004007 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 941967004008 PYR/PP interface [polypeptide binding]; other site 941967004009 dimer interface [polypeptide binding]; other site 941967004010 TPP binding site [chemical binding]; other site 941967004011 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 941967004012 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 941967004013 TPP-binding site [chemical binding]; other site 941967004014 dimer interface [polypeptide binding]; other site 941967004015 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 941967004016 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 941967004017 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 941967004018 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 941967004019 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941967004020 motif II; other site 941967004021 Predicted flavoproteins [General function prediction only]; Region: COG2081 941967004022 Predicted flavoproteins [General function prediction only]; Region: COG2081 941967004023 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 941967004024 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 941967004025 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 941967004026 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 941967004027 protein binding site [polypeptide binding]; other site 941967004028 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 941967004029 protein binding site [polypeptide binding]; other site 941967004030 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 941967004031 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 941967004032 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 941967004033 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 941967004034 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 941967004035 HflK protein; Region: hflK; TIGR01933 941967004036 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 941967004037 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 941967004038 folate binding site [chemical binding]; other site 941967004039 NADP+ binding site [chemical binding]; other site 941967004040 thymidylate synthase; Reviewed; Region: thyA; PRK01827 941967004041 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 941967004042 dimerization interface [polypeptide binding]; other site 941967004043 active site 941967004044 Protein of unknown function (DUF2853); Region: DUF2853; pfam11015 941967004045 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941967004046 putative substrate translocation pore; other site 941967004047 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 941967004048 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941967004049 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 941967004050 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814 941967004051 Domain of unknown function (DUF4169); Region: DUF4169; pfam13770 941967004052 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 941967004053 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 941967004054 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 941967004055 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 941967004056 FAD binding domain; Region: FAD_binding_4; pfam01565 941967004057 Uncharacterized conserved protein [Function unknown]; Region: COG4702 941967004058 serine/threonine protein kinase; Provisional; Region: PRK09188 941967004059 serine/threonine protein kinase; Provisional; Region: PRK12274 941967004060 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 941967004061 Part of AAA domain; Region: AAA_19; pfam13245 941967004062 Family description; Region: UvrD_C_2; pfam13538 941967004063 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 941967004064 CreA protein; Region: CreA; pfam05981 941967004065 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 941967004066 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 941967004067 trimer interface [polypeptide binding]; other site 941967004068 active site 941967004069 substrate binding site [chemical binding]; other site 941967004070 CoA binding site [chemical binding]; other site 941967004071 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 941967004072 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 941967004073 Cu(I) binding site [ion binding]; other site 941967004074 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 941967004075 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941967004076 S-adenosylmethionine binding site [chemical binding]; other site 941967004077 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 941967004078 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 941967004079 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 941967004080 active site 941967004081 Uncharacterized conserved protein [Function unknown]; Region: COG5587 941967004082 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 941967004083 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 941967004084 nucleotide binding pocket [chemical binding]; other site 941967004085 K-X-D-G motif; other site 941967004086 catalytic site [active] 941967004087 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 941967004088 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 941967004089 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 941967004090 Dimer interface [polypeptide binding]; other site 941967004091 BRCT sequence motif; other site 941967004092 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 941967004093 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 941967004094 Walker A/P-loop; other site 941967004095 ATP binding site [chemical binding]; other site 941967004096 Q-loop/lid; other site 941967004097 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 941967004098 ABC transporter signature motif; other site 941967004099 Walker B; other site 941967004100 D-loop; other site 941967004101 H-loop/switch region; other site 941967004102 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 941967004103 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 941967004104 binding surface 941967004105 TPR motif; other site 941967004106 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 941967004107 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 941967004108 cell division protein FtsZ; Validated; Region: PRK09330 941967004109 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 941967004110 nucleotide binding site [chemical binding]; other site 941967004111 SulA interaction site; other site 941967004112 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 941967004113 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 941967004114 Cell division protein FtsA; Region: FtsA; smart00842 941967004115 Cell division protein FtsA; Region: FtsA; pfam14450 941967004116 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 941967004117 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 941967004118 Cell division protein FtsQ; Region: FtsQ; pfam03799 941967004119 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 941967004120 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 941967004121 ATP-grasp domain; Region: ATP-grasp_4; cl17255 941967004122 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 941967004123 FAD binding domain; Region: FAD_binding_4; pfam01565 941967004124 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 941967004125 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 941967004126 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 941967004127 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 941967004128 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 941967004129 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 941967004130 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 941967004131 active site 941967004132 homodimer interface [polypeptide binding]; other site 941967004133 cell division protein FtsW; Region: ftsW; TIGR02614 941967004134 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 941967004135 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 941967004136 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 941967004137 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 941967004138 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 941967004139 Mg++ binding site [ion binding]; other site 941967004140 putative catalytic motif [active] 941967004141 putative substrate binding site [chemical binding]; other site 941967004142 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093 941967004143 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 941967004144 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 941967004145 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 941967004146 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 941967004147 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 941967004148 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 941967004149 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 941967004150 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 941967004151 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 941967004152 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 941967004153 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 941967004154 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 941967004155 MraW methylase family; Region: Methyltransf_5; cl17771 941967004156 manganese transport protein MntH; Reviewed; Region: PRK00701 941967004157 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 941967004158 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 941967004159 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 941967004160 N-acetyl-D-glucosamine binding site [chemical binding]; other site 941967004161 catalytic residue [active] 941967004162 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 941967004163 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 941967004164 amidase catalytic site [active] 941967004165 Zn binding residues [ion binding]; other site 941967004166 substrate binding site [chemical binding]; other site 941967004167 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 941967004168 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 941967004169 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 941967004170 putative metal binding site [ion binding]; other site 941967004171 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 941967004172 HSP70 interaction site [polypeptide binding]; other site 941967004173 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 941967004174 active site 941967004175 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 941967004176 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 941967004177 murein hydrolase B; Provisional; Region: PRK10760; cl17906 941967004178 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 941967004179 Predicted permeases [General function prediction only]; Region: COG0679 941967004180 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 941967004181 FAD binding site [chemical binding]; other site 941967004182 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 941967004183 dimerization interface [polypeptide binding]; other site 941967004184 putative DNA binding site [nucleotide binding]; other site 941967004185 putative Zn2+ binding site [ion binding]; other site 941967004186 Methyltransferase domain; Region: Methyltransf_23; pfam13489 941967004187 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941967004188 S-adenosylmethionine binding site [chemical binding]; other site 941967004189 Uncharacterized conserved protein [Function unknown]; Region: COG5586 941967004190 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 941967004191 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941967004192 putative substrate translocation pore; other site 941967004193 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 941967004194 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941967004195 S-adenosylmethionine binding site [chemical binding]; other site 941967004196 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 941967004197 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941967004198 Walker A/P-loop; other site 941967004199 ATP binding site [chemical binding]; other site 941967004200 Q-loop/lid; other site 941967004201 ABC transporter signature motif; other site 941967004202 Walker B; other site 941967004203 D-loop; other site 941967004204 H-loop/switch region; other site 941967004205 ABC transporter; Region: ABC_tran_2; pfam12848 941967004206 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 941967004207 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 941967004208 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 941967004209 PGAP1-like protein; Region: PGAP1; pfam07819 941967004210 Protein of unknown function (DUF1498); Region: DUF1498; pfam07385 941967004211 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 941967004212 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 941967004213 [2Fe-2S] cluster binding site [ion binding]; other site 941967004214 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 941967004215 putative alpha subunit interface [polypeptide binding]; other site 941967004216 putative active site [active] 941967004217 putative substrate binding site [chemical binding]; other site 941967004218 Fe binding site [ion binding]; other site 941967004219 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 941967004220 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 941967004221 FAD binding pocket [chemical binding]; other site 941967004222 FAD binding motif [chemical binding]; other site 941967004223 phosphate binding motif [ion binding]; other site 941967004224 beta-alpha-beta structure motif; other site 941967004225 NAD binding pocket [chemical binding]; other site 941967004226 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 941967004227 catalytic loop [active] 941967004228 iron binding site [ion binding]; other site 941967004229 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 941967004230 PhnA protein; Region: PhnA; pfam03831 941967004231 Isochorismatase family; Region: Isochorismatase; pfam00857 941967004232 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 941967004233 catalytic triad [active] 941967004234 metal binding site [ion binding]; metal-binding site 941967004235 conserved cis-peptide bond; other site 941967004236 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899 941967004237 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 941967004238 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 941967004239 active site 941967004240 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 941967004241 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 941967004242 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 941967004243 DNA binding site [nucleotide binding] 941967004244 active site 941967004245 Int/Topo IB signature motif; other site 941967004246 Uncharacterized conserved protein [Function unknown]; Region: COG2968 941967004247 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 941967004248 hypothetical protein; Provisional; Region: PRK05170 941967004249 Uncharacterized conserved protein [Function unknown]; Region: COG5453 941967004250 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 941967004251 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 941967004252 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 941967004253 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 941967004254 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941967004255 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 941967004256 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941967004257 DNA binding residues [nucleotide binding] 941967004258 DNA primase; Validated; Region: dnaG; PRK05667 941967004259 CHC2 zinc finger; Region: zf-CHC2; pfam01807 941967004260 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 941967004261 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 941967004262 active site 941967004263 metal binding site [ion binding]; metal-binding site 941967004264 interdomain interaction site; other site 941967004265 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 941967004266 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 941967004267 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 941967004268 PhoU domain; Region: PhoU; pfam01895 941967004269 PhoU domain; Region: PhoU; pfam01895 941967004270 Uncharacterized conserved protein [Function unknown]; Region: COG1610 941967004271 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 941967004272 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 941967004273 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 941967004274 catalytic site [active] 941967004275 subunit interface [polypeptide binding]; other site 941967004276 Predicted metalloprotease [General function prediction only]; Region: COG2321 941967004277 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 941967004278 Predicted membrane protein [Function unknown]; Region: COG5395 941967004279 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 941967004280 LytTr DNA-binding domain; Region: LytTR; cl04498 941967004281 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 941967004282 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 941967004283 ATP-grasp domain; Region: ATP-grasp_4; cl17255 941967004284 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 941967004285 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 941967004286 ATP-grasp domain; Region: ATP-grasp_4; cl17255 941967004287 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 941967004288 IMP binding site; other site 941967004289 dimer interface [polypeptide binding]; other site 941967004290 partial ornithine binding site; other site 941967004291 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 941967004292 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 941967004293 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 941967004294 NUDIX domain; Region: NUDIX; pfam00293 941967004295 nudix motif; other site 941967004296 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 941967004297 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 941967004298 putative C-terminal domain interface [polypeptide binding]; other site 941967004299 putative GSH binding site (G-site) [chemical binding]; other site 941967004300 putative dimer interface [polypeptide binding]; other site 941967004301 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 941967004302 N-terminal domain interface [polypeptide binding]; other site 941967004303 dimer interface [polypeptide binding]; other site 941967004304 substrate binding pocket (H-site) [chemical binding]; other site 941967004305 aspartate aminotransferase; Provisional; Region: PRK05764 941967004306 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941967004307 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941967004308 homodimer interface [polypeptide binding]; other site 941967004309 catalytic residue [active] 941967004310 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941967004311 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941967004312 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 941967004313 putative effector binding pocket; other site 941967004314 dimerization interface [polypeptide binding]; other site 941967004315 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 941967004316 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 941967004317 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 941967004318 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 941967004319 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 941967004320 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 941967004321 putative DNA binding site [nucleotide binding]; other site 941967004322 putative Zn2+ binding site [ion binding]; other site 941967004323 AsnC family; Region: AsnC_trans_reg; pfam01037 941967004324 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 941967004325 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 941967004326 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 941967004327 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 941967004328 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 941967004329 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 941967004330 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 941967004331 EamA-like transporter family; Region: EamA; pfam00892 941967004332 EamA-like transporter family; Region: EamA; pfam00892 941967004333 Protein of unknown function, DUF486; Region: DUF486; cl01236 941967004334 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921 941967004335 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 941967004336 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 941967004337 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 941967004338 Bacterial SH3 domain; Region: SH3_3; pfam08239 941967004339 excinuclease ABC subunit B; Provisional; Region: PRK05298 941967004340 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 941967004341 ATP binding site [chemical binding]; other site 941967004342 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941967004343 nucleotide binding region [chemical binding]; other site 941967004344 ATP-binding site [chemical binding]; other site 941967004345 Ultra-violet resistance protein B; Region: UvrB; pfam12344 941967004346 UvrB/uvrC motif; Region: UVR; pfam02151 941967004347 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 941967004348 N-acetyl-D-glucosamine binding site [chemical binding]; other site 941967004349 catalytic residue [active] 941967004350 BA14K-like protein; Region: BA14K; pfam07886 941967004351 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 941967004352 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 941967004353 MarR family; Region: MarR_2; pfam12802 941967004354 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941967004355 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941967004356 active site 941967004357 phosphorylation site [posttranslational modification] 941967004358 intermolecular recognition site; other site 941967004359 dimerization interface [polypeptide binding]; other site 941967004360 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941967004361 DNA binding site [nucleotide binding] 941967004362 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 941967004363 dimer interface [polypeptide binding]; other site 941967004364 phosphorylation site [posttranslational modification] 941967004365 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941967004366 ATP binding site [chemical binding]; other site 941967004367 Mg2+ binding site [ion binding]; other site 941967004368 G-X-G motif; other site 941967004369 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 941967004370 dimer interface [polypeptide binding]; other site 941967004371 putative tRNA-binding site [nucleotide binding]; other site 941967004372 Uncharacterized conserved protein [Function unknown]; Region: COG5465 941967004373 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 941967004374 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 941967004375 Uncharacterized conserved protein [Function unknown]; Region: COG1565 941967004376 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 941967004377 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 941967004378 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 941967004379 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 941967004380 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 941967004381 active site 941967004382 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 941967004383 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 941967004384 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 941967004385 active site 941967004386 HerA helicase [Replication, recombination, and repair]; Region: COG0433 941967004387 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 941967004388 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 941967004389 5S rRNA interface [nucleotide binding]; other site 941967004390 CTC domain interface [polypeptide binding]; other site 941967004391 L16 interface [polypeptide binding]; other site 941967004392 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 941967004393 putative active site [active] 941967004394 catalytic residue [active] 941967004395 GTP-binding protein YchF; Reviewed; Region: PRK09601 941967004396 YchF GTPase; Region: YchF; cd01900 941967004397 G1 box; other site 941967004398 GTP/Mg2+ binding site [chemical binding]; other site 941967004399 Switch I region; other site 941967004400 G2 box; other site 941967004401 Switch II region; other site 941967004402 G3 box; other site 941967004403 G4 box; other site 941967004404 G5 box; other site 941967004405 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 941967004406 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 941967004407 putative active site [active] 941967004408 putative catalytic site [active] 941967004409 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 941967004410 putative active site [active] 941967004411 putative catalytic site [active] 941967004412 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 941967004413 active site 941967004414 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 941967004415 cytochrome b; Provisional; Region: CYTB; MTH00191 941967004416 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 941967004417 Qi binding site; other site 941967004418 intrachain domain interface; other site 941967004419 interchain domain interface [polypeptide binding]; other site 941967004420 heme bH binding site [chemical binding]; other site 941967004421 heme bL binding site [chemical binding]; other site 941967004422 Qo binding site; other site 941967004423 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 941967004424 interchain domain interface [polypeptide binding]; other site 941967004425 intrachain domain interface; other site 941967004426 Qi binding site; other site 941967004427 Qo binding site; other site 941967004428 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 941967004429 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 941967004430 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 941967004431 [2Fe-2S] cluster binding site [ion binding]; other site 941967004432 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 941967004433 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 941967004434 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941967004435 Walker A/P-loop; other site 941967004436 ATP binding site [chemical binding]; other site 941967004437 Q-loop/lid; other site 941967004438 ABC transporter signature motif; other site 941967004439 Walker B; other site 941967004440 D-loop; other site 941967004441 H-loop/switch region; other site 941967004442 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 941967004443 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 941967004444 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 941967004445 Walker A/P-loop; other site 941967004446 ATP binding site [chemical binding]; other site 941967004447 Q-loop/lid; other site 941967004448 ABC transporter signature motif; other site 941967004449 Walker B; other site 941967004450 D-loop; other site 941967004451 H-loop/switch region; other site 941967004452 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 941967004453 Purine nucleoside permease [Nucleotide transport and metabolism]; Region: NUP; COG5042 941967004454 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 941967004455 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752 941967004456 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941967004457 Coenzyme A binding pocket [chemical binding]; other site 941967004458 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 941967004459 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 941967004460 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 941967004461 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 941967004462 active site 941967004463 NTP binding site [chemical binding]; other site 941967004464 metal binding triad [ion binding]; metal-binding site 941967004465 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 941967004466 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 941967004467 putative active site [active] 941967004468 putative CoA binding site [chemical binding]; other site 941967004469 nudix motif; other site 941967004470 metal binding site [ion binding]; metal-binding site 941967004471 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816 941967004472 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 941967004473 MoxR-like ATPases [General function prediction only]; Region: COG0714 941967004474 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 941967004475 ATP binding site [chemical binding]; other site 941967004476 Walker B motif; other site 941967004477 arginine finger; other site 941967004478 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 941967004479 Protein of unknown function DUF58; Region: DUF58; pfam01882 941967004480 N-terminal double-transmembrane domain; Region: two_anch; TIGR02226 941967004481 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 941967004482 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 941967004483 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 941967004484 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 941967004485 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941967004486 Coenzyme A binding pocket [chemical binding]; other site 941967004487 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 941967004488 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 941967004489 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 941967004490 putative dimer interface [polypeptide binding]; other site 941967004491 N-terminal domain interface [polypeptide binding]; other site 941967004492 putative substrate binding pocket (H-site) [chemical binding]; other site 941967004493 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 941967004494 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 941967004495 nudix motif; other site 941967004496 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 941967004497 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 941967004498 active site 941967004499 metal binding site [ion binding]; metal-binding site 941967004500 2-isopropylmalate synthase; Validated; Region: PRK03739 941967004501 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 941967004502 active site 941967004503 catalytic residues [active] 941967004504 metal binding site [ion binding]; metal-binding site 941967004505 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 941967004506 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 941967004507 Cation efflux family; Region: Cation_efflux; pfam01545 941967004508 anthranilate synthase; Provisional; Region: PRK13566 941967004509 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 941967004510 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 941967004511 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 941967004512 glutamine binding [chemical binding]; other site 941967004513 catalytic triad [active] 941967004514 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 941967004515 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 941967004516 putative DNA binding site [nucleotide binding]; other site 941967004517 putative Zn2+ binding site [ion binding]; other site 941967004518 AsnC family; Region: AsnC_trans_reg; pfam01037 941967004519 Transcriptional regulators [Transcription]; Region: MarR; COG1846 941967004520 MarR family; Region: MarR_2; pfam12802 941967004521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941967004522 putative substrate translocation pore; other site 941967004523 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941967004524 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG5459 941967004525 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5345 941967004526 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 941967004527 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 941967004528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967004529 dimer interface [polypeptide binding]; other site 941967004530 conserved gate region; other site 941967004531 putative PBP binding loops; other site 941967004532 ABC-ATPase subunit interface; other site 941967004533 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 941967004534 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941967004535 Walker A/P-loop; other site 941967004536 ATP binding site [chemical binding]; other site 941967004537 Q-loop/lid; other site 941967004538 ABC transporter signature motif; other site 941967004539 Walker B; other site 941967004540 D-loop; other site 941967004541 H-loop/switch region; other site 941967004542 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 941967004543 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 941967004544 Walker A/P-loop; other site 941967004545 ATP binding site [chemical binding]; other site 941967004546 Q-loop/lid; other site 941967004547 ABC transporter signature motif; other site 941967004548 Walker B; other site 941967004549 D-loop; other site 941967004550 H-loop/switch region; other site 941967004551 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 941967004552 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 941967004553 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 941967004554 Walker A/P-loop; other site 941967004555 ATP binding site [chemical binding]; other site 941967004556 Q-loop/lid; other site 941967004557 ABC transporter signature motif; other site 941967004558 Walker B; other site 941967004559 D-loop; other site 941967004560 H-loop/switch region; other site 941967004561 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 941967004562 dipeptide transporter; Provisional; Region: PRK10913 941967004563 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 941967004564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967004565 dimer interface [polypeptide binding]; other site 941967004566 conserved gate region; other site 941967004567 putative PBP binding loops; other site 941967004568 ABC-ATPase subunit interface; other site 941967004569 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 941967004570 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967004571 dimer interface [polypeptide binding]; other site 941967004572 conserved gate region; other site 941967004573 putative PBP binding loops; other site 941967004574 ABC-ATPase subunit interface; other site 941967004575 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 941967004576 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 941967004577 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 941967004578 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 941967004579 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 941967004580 putative DNA binding site [nucleotide binding]; other site 941967004581 putative Zn2+ binding site [ion binding]; other site 941967004582 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 941967004583 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 941967004584 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 941967004585 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 941967004586 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 941967004587 Ligand Binding Site [chemical binding]; other site 941967004588 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 941967004589 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 941967004590 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5400 941967004591 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5385 941967004592 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941967004593 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941967004594 active site 941967004595 phosphorylation site [posttranslational modification] 941967004596 intermolecular recognition site; other site 941967004597 dimerization interface [polypeptide binding]; other site 941967004598 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941967004599 DNA binding site [nucleotide binding] 941967004600 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 941967004601 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 941967004602 inhibitor-cofactor binding pocket; inhibition site 941967004603 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941967004604 catalytic residue [active] 941967004605 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 941967004606 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 941967004607 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 941967004608 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 941967004609 PAS domain; Region: PAS_8; pfam13188 941967004610 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 941967004611 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941967004612 putative active site [active] 941967004613 heme pocket [chemical binding]; other site 941967004614 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941967004615 dimer interface [polypeptide binding]; other site 941967004616 phosphorylation site [posttranslational modification] 941967004617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941967004618 ATP binding site [chemical binding]; other site 941967004619 Mg2+ binding site [ion binding]; other site 941967004620 G-X-G motif; other site 941967004621 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 941967004622 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 941967004623 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 941967004624 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967004625 dimer interface [polypeptide binding]; other site 941967004626 conserved gate region; other site 941967004627 putative PBP binding loops; other site 941967004628 ABC-ATPase subunit interface; other site 941967004629 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967004630 dimer interface [polypeptide binding]; other site 941967004631 conserved gate region; other site 941967004632 putative PBP binding loops; other site 941967004633 ABC-ATPase subunit interface; other site 941967004634 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 941967004635 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 941967004636 Walker A/P-loop; other site 941967004637 ATP binding site [chemical binding]; other site 941967004638 Q-loop/lid; other site 941967004639 ABC transporter signature motif; other site 941967004640 Walker B; other site 941967004641 D-loop; other site 941967004642 H-loop/switch region; other site 941967004643 TOBE domain; Region: TOBE_2; pfam08402 941967004644 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 941967004645 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 941967004646 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 941967004647 Domain of unknown function (DUF955); Region: DUF955; pfam06114 941967004648 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 941967004649 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941967004650 non-specific DNA binding site [nucleotide binding]; other site 941967004651 salt bridge; other site 941967004652 sequence-specific DNA binding site [nucleotide binding]; other site 941967004653 isocitrate lyase; Provisional; Region: PRK15063 941967004654 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 941967004655 tetramer interface [polypeptide binding]; other site 941967004656 active site 941967004657 Mg2+/Mn2+ binding site [ion binding]; other site 941967004658 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 941967004659 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 941967004660 NAD binding site [chemical binding]; other site 941967004661 substrate binding site [chemical binding]; other site 941967004662 homotetramer interface [polypeptide binding]; other site 941967004663 homodimer interface [polypeptide binding]; other site 941967004664 active site 941967004665 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 941967004666 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 941967004667 NAD binding site [chemical binding]; other site 941967004668 substrate binding site [chemical binding]; other site 941967004669 homotetramer interface [polypeptide binding]; other site 941967004670 homodimer interface [polypeptide binding]; other site 941967004671 active site 941967004672 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 941967004673 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 941967004674 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 941967004675 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 941967004676 active site 941967004677 nucleophile elbow; other site 941967004678 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 941967004679 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 941967004680 DAK2 domain; Region: Dak2; cl03685 941967004681 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 941967004682 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941967004683 DNA binding residues [nucleotide binding] 941967004684 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 941967004685 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 941967004686 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 941967004687 DAK2 domain; Region: Dak2; pfam02734 941967004688 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 941967004689 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 941967004690 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941967004691 classical (c) SDRs; Region: SDR_c; cd05233 941967004692 NAD(P) binding site [chemical binding]; other site 941967004693 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 941967004694 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 941967004695 putative ligand binding site [chemical binding]; other site 941967004696 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 941967004697 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 941967004698 TM-ABC transporter signature motif; other site 941967004699 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 941967004700 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 941967004701 Q-loop/lid; other site 941967004702 ABC transporter signature motif; other site 941967004703 Walker B; other site 941967004704 D-loop; other site 941967004705 H-loop/switch region; other site 941967004706 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 941967004707 Uncharacterized conserved protein [Function unknown]; Region: COG5591 941967004708 choline dehydrogenase; Validated; Region: PRK02106 941967004709 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 941967004710 Transcriptional regulator [Transcription]; Region: IclR; COG1414 941967004711 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 941967004712 Bacterial transcriptional regulator; Region: IclR; pfam01614 941967004713 succinic semialdehyde dehydrogenase; Region: PLN02278 941967004714 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 941967004715 tetramerization interface [polypeptide binding]; other site 941967004716 NAD(P) binding site [chemical binding]; other site 941967004717 catalytic residues [active] 941967004718 Predicted membrane protein [Function unknown]; Region: COG1238 941967004719 Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495 941967004720 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 941967004721 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 941967004722 active site 941967004723 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 941967004724 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 941967004725 helix-hairpin-helix signature motif; other site 941967004726 substrate binding pocket [chemical binding]; other site 941967004727 active site 941967004728 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 941967004729 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 941967004730 active site 941967004731 HIGH motif; other site 941967004732 nucleotide binding site [chemical binding]; other site 941967004733 active site 941967004734 KMSKS motif; other site 941967004735 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 941967004736 active site 941967004737 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 941967004738 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941967004739 Coenzyme A binding pocket [chemical binding]; other site 941967004740 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 941967004741 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 941967004742 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941967004743 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941967004744 DNA binding residues [nucleotide binding] 941967004745 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 941967004746 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 941967004747 RNA binding surface [nucleotide binding]; other site 941967004748 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 941967004749 active site 941967004750 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 941967004751 metal binding site 2 [ion binding]; metal-binding site 941967004752 putative DNA binding helix; other site 941967004753 metal binding site 1 [ion binding]; metal-binding site 941967004754 dimer interface [polypeptide binding]; other site 941967004755 structural Zn2+ binding site [ion binding]; other site 941967004756 PAS fold; Region: PAS_4; pfam08448 941967004757 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 941967004758 HWE histidine kinase; Region: HWE_HK; pfam07536 941967004759 two-component response regulator; Provisional; Region: PRK09191 941967004760 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941967004761 active site 941967004762 phosphorylation site [posttranslational modification] 941967004763 intermolecular recognition site; other site 941967004764 dimerization interface [polypeptide binding]; other site 941967004765 RNA polymerase sigma factor; Provisional; Region: PRK12516 941967004766 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941967004767 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941967004768 DNA binding residues [nucleotide binding] 941967004769 CHASE3 domain; Region: CHASE3; pfam05227 941967004770 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 941967004771 Histidine kinase; Region: HisKA_2; pfam07568 941967004772 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941967004773 ATP binding site [chemical binding]; other site 941967004774 Mg2+ binding site [ion binding]; other site 941967004775 G-X-G motif; other site 941967004776 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 941967004777 PRC-barrel domain; Region: PRC; pfam05239 941967004778 PRC-barrel domain; Region: PRC; pfam05239 941967004779 tonB-system energizer ExbB; Region: exbB; TIGR02797 941967004780 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 941967004781 TonB system transport protein ExbD, group 1; Region: ExbD_1; TIGR02803 941967004782 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 941967004783 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 941967004784 Predicted periplasmic protein [Function unknown]; Region: COG3698 941967004785 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 941967004786 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 941967004787 FtsX-like permease family; Region: FtsX; pfam02687 941967004788 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 941967004789 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 941967004790 Walker A/P-loop; other site 941967004791 ATP binding site [chemical binding]; other site 941967004792 ABC transporter; Region: ABC_tran; pfam00005 941967004793 Q-loop/lid; other site 941967004794 ABC transporter signature motif; other site 941967004795 Walker B; other site 941967004796 D-loop; other site 941967004797 macrolide transporter subunit MacA; Provisional; Region: PRK11578 941967004798 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 941967004799 HlyD family secretion protein; Region: HlyD_3; pfam13437 941967004800 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 941967004801 trimer interface [polypeptide binding]; other site 941967004802 active site 941967004803 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 941967004804 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 941967004805 dimerization interface [polypeptide binding]; other site 941967004806 putative DNA binding site [nucleotide binding]; other site 941967004807 putative Zn2+ binding site [ion binding]; other site 941967004808 AsnC family; Region: AsnC_trans_reg; pfam01037 941967004809 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 941967004810 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 941967004811 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 941967004812 putative dimer interface [polypeptide binding]; other site 941967004813 putative active site [active] 941967004814 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 941967004815 diiron binding motif [ion binding]; other site 941967004816 Uncharacterized conserved protein [Function unknown]; Region: COG1633 941967004817 CCC1-related protein family; Region: CCC1_like_1; cd02437 941967004818 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941967004819 metabolite-proton symporter; Region: 2A0106; TIGR00883 941967004820 putative substrate translocation pore; other site 941967004821 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 941967004822 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 941967004823 GDP-binding site [chemical binding]; other site 941967004824 ACT binding site; other site 941967004825 IMP binding site; other site 941967004826 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 941967004827 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941967004828 Coenzyme A binding pocket [chemical binding]; other site 941967004829 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 941967004830 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 941967004831 ligand binding site [chemical binding]; other site 941967004832 NAD binding site [chemical binding]; other site 941967004833 dimerization interface [polypeptide binding]; other site 941967004834 catalytic site [active] 941967004835 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 941967004836 putative L-serine binding site [chemical binding]; other site 941967004837 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 941967004838 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 941967004839 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 941967004840 catalytic residue [active] 941967004841 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 941967004842 Sodium Bile acid symporter family; Region: SBF; pfam01758 941967004843 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 941967004844 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 941967004845 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 941967004846 active site 941967004847 substrate binding site [chemical binding]; other site 941967004848 metal binding site [ion binding]; metal-binding site 941967004849 FtsH Extracellular; Region: FtsH_ext; pfam06480 941967004850 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 941967004851 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941967004852 Walker A motif; other site 941967004853 ATP binding site [chemical binding]; other site 941967004854 Walker B motif; other site 941967004855 arginine finger; other site 941967004856 Peptidase family M41; Region: Peptidase_M41; pfam01434 941967004857 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 941967004858 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 941967004859 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 941967004860 Tetratricopeptide repeat; Region: TPR_6; pfam13174 941967004861 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 941967004862 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 941967004863 ligand binding site [chemical binding]; other site 941967004864 translocation protein TolB; Provisional; Region: tolB; PRK05137 941967004865 TolB amino-terminal domain; Region: TolB_N; pfam04052 941967004866 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 941967004867 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 941967004868 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 941967004869 TolR protein; Region: tolR; TIGR02801 941967004870 TolQ protein; Region: tolQ; TIGR02796 941967004871 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 941967004872 active site 941967004873 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 941967004874 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941967004875 Walker A motif; other site 941967004876 ATP binding site [chemical binding]; other site 941967004877 Walker B motif; other site 941967004878 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 941967004879 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 941967004880 RuvA N terminal domain; Region: RuvA_N; pfam01330 941967004881 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 941967004882 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 941967004883 active site 941967004884 putative DNA-binding cleft [nucleotide binding]; other site 941967004885 dimer interface [polypeptide binding]; other site 941967004886 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5317 941967004887 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4645 941967004888 Acyltransferase family; Region: Acyl_transf_3; pfam01757 941967004889 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 941967004890 active site 941967004891 thiamine phosphate binding site [chemical binding]; other site 941967004892 pyrophosphate binding site [ion binding]; other site 941967004893 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 941967004894 Sel1-like repeats; Region: SEL1; smart00671 941967004895 Sel1-like repeats; Region: SEL1; smart00671 941967004896 elongation factor P; Validated; Region: PRK00529 941967004897 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 941967004898 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 941967004899 RNA binding site [nucleotide binding]; other site 941967004900 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 941967004901 RNA binding site [nucleotide binding]; other site 941967004902 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 941967004903 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 941967004904 active site 941967004905 dimerization interface [polypeptide binding]; other site 941967004906 hypothetical protein; Validated; Region: PRK09039 941967004907 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 941967004908 ligand binding site [chemical binding]; other site 941967004909 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 941967004910 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 941967004911 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941967004912 Walker A/P-loop; other site 941967004913 ATP binding site [chemical binding]; other site 941967004914 Q-loop/lid; other site 941967004915 ABC transporter signature motif; other site 941967004916 Walker B; other site 941967004917 D-loop; other site 941967004918 H-loop/switch region; other site 941967004919 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 941967004920 hypothetical protein; Validated; Region: PRK00110 941967004921 Transcriptional regulators [Transcription]; Region: GntR; COG1802 941967004922 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 941967004923 DNA-binding site [nucleotide binding]; DNA binding site 941967004924 FCD domain; Region: FCD; pfam07729 941967004925 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 941967004926 Uncharacterized conserved protein [Function unknown]; Region: COG3543 941967004927 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 941967004928 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 941967004929 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 941967004930 putative active site [active] 941967004931 metal binding site [ion binding]; metal-binding site 941967004932 homodimer binding site [polypeptide binding]; other site 941967004933 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 941967004934 Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division, chromosome partitioning]; Region: zapA; COG3027 941967004935 Domain of unknown function (DUF4164); Region: DUF4164; pfam13747 941967004936 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 941967004937 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 941967004938 TPP-binding site [chemical binding]; other site 941967004939 dimer interface [polypeptide binding]; other site 941967004940 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 941967004941 PYR/PP interface [polypeptide binding]; other site 941967004942 dimer interface [polypeptide binding]; other site 941967004943 TPP binding site [chemical binding]; other site 941967004944 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 941967004945 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 941967004946 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 941967004947 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 941967004948 Phosphoglycerate kinase; Region: PGK; pfam00162 941967004949 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 941967004950 substrate binding site [chemical binding]; other site 941967004951 hinge regions; other site 941967004952 ADP binding site [chemical binding]; other site 941967004953 catalytic site [active] 941967004954 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 941967004955 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 941967004956 acyl-activating enzyme (AAE) consensus motif; other site 941967004957 putative AMP binding site [chemical binding]; other site 941967004958 putative active site [active] 941967004959 putative CoA binding site [chemical binding]; other site 941967004960 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941967004961 Predicted transcriptional regulator [Transcription]; Region: COG2378 941967004962 HTH domain; Region: HTH_11; pfam08279 941967004963 WYL domain; Region: WYL; pfam13280 941967004964 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 941967004965 CoenzymeA binding site [chemical binding]; other site 941967004966 subunit interaction site [polypeptide binding]; other site 941967004967 PHB binding site; other site 941967004968 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 941967004969 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820 941967004970 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 941967004971 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 941967004972 NAD(P) binding site [chemical binding]; other site 941967004973 Uncharacterized small protein containing a coiled-coil domain [Function unknown]; Region: COG5509 941967004974 putative MFS family transporter protein; Provisional; Region: PRK03633 941967004975 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941967004976 putative substrate translocation pore; other site 941967004977 Uncharacterized small protein [Function unknown]; Region: COG5570 941967004978 Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481 941967004979 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 941967004980 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 941967004981 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 941967004982 NAD binding site [chemical binding]; other site 941967004983 ATP-grasp domain; Region: ATP-grasp; pfam02222 941967004984 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 941967004985 TPR repeat; Region: TPR_11; pfam13414 941967004986 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 941967004987 TPR motif; other site 941967004988 binding surface 941967004989 pyruvate kinase; Provisional; Region: PRK06247 941967004990 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 941967004991 domain interfaces; other site 941967004992 active site 941967004993 Predicted integral membrane protein [Function unknown]; Region: COG5480 941967004994 Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931 941967004995 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3750 941967004996 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 941967004997 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 941967004998 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 941967004999 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 941967005000 Thiamine pyrophosphokinase; Region: TPK; cd07995 941967005001 active site 941967005002 dimerization interface [polypeptide binding]; other site 941967005003 thiamine binding site [chemical binding]; other site 941967005004 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 941967005005 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 941967005006 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 941967005007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967005008 dimer interface [polypeptide binding]; other site 941967005009 conserved gate region; other site 941967005010 putative PBP binding loops; other site 941967005011 ABC-ATPase subunit interface; other site 941967005012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967005013 dimer interface [polypeptide binding]; other site 941967005014 conserved gate region; other site 941967005015 putative PBP binding loops; other site 941967005016 ABC-ATPase subunit interface; other site 941967005017 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 941967005018 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 941967005019 Walker A/P-loop; other site 941967005020 ATP binding site [chemical binding]; other site 941967005021 Q-loop/lid; other site 941967005022 ABC transporter signature motif; other site 941967005023 Walker B; other site 941967005024 D-loop; other site 941967005025 H-loop/switch region; other site 941967005026 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 941967005027 Peptidase family M48; Region: Peptidase_M48; pfam01435 941967005028 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 941967005029 MOSC domain; Region: MOSC; pfam03473 941967005030 3-alpha domain; Region: 3-alpha; pfam03475 941967005031 RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500 941967005032 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941967005033 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941967005034 DNA binding residues [nucleotide binding] 941967005035 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 941967005036 Ferredoxin [Energy production and conversion]; Region: COG1146 941967005037 4Fe-4S binding domain; Region: Fer4; pfam00037 941967005038 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 941967005039 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 941967005040 RNA binding surface [nucleotide binding]; other site 941967005041 DEAD/DEAH box helicase; Region: DEAD; pfam00270 941967005042 ATP binding site [chemical binding]; other site 941967005043 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 941967005044 putative Mg++ binding site [ion binding]; other site 941967005045 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941967005046 nucleotide binding region [chemical binding]; other site 941967005047 ATP-binding site [chemical binding]; other site 941967005048 putative acyltransferase; Provisional; Region: PRK05790 941967005049 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 941967005050 dimer interface [polypeptide binding]; other site 941967005051 active site 941967005052 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 941967005053 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 941967005054 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 941967005055 Transglycosylase; Region: Transgly; pfam00912 941967005056 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 941967005057 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 941967005058 substrate binding pocket [chemical binding]; other site 941967005059 chain length determination region; other site 941967005060 substrate-Mg2+ binding site; other site 941967005061 catalytic residues [active] 941967005062 aspartate-rich region 1; other site 941967005063 active site lid residues [active] 941967005064 aspartate-rich region 2; other site 941967005065 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 941967005066 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 941967005067 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 941967005068 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 941967005069 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941967005070 NAD(P) binding site [chemical binding]; other site 941967005071 active site 941967005072 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941967005073 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941967005074 putative substrate translocation pore; other site 941967005075 pyruvate carboxylase; Reviewed; Region: PRK12999 941967005076 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 941967005077 ATP-grasp domain; Region: ATP-grasp_4; cl17255 941967005078 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 941967005079 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 941967005080 active site 941967005081 catalytic residues [active] 941967005082 metal binding site [ion binding]; metal-binding site 941967005083 homodimer binding site [polypeptide binding]; other site 941967005084 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 941967005085 carboxyltransferase (CT) interaction site; other site 941967005086 biotinylation site [posttranslational modification]; other site 941967005087 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 941967005088 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 941967005089 dimerization interface [polypeptide binding]; other site 941967005090 ligand binding site [chemical binding]; other site 941967005091 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 941967005092 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 941967005093 dimerization interface [polypeptide binding]; other site 941967005094 ligand binding site [chemical binding]; other site 941967005095 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 941967005096 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 941967005097 Walker A/P-loop; other site 941967005098 ATP binding site [chemical binding]; other site 941967005099 Q-loop/lid; other site 941967005100 ABC transporter signature motif; other site 941967005101 Walker B; other site 941967005102 D-loop; other site 941967005103 H-loop/switch region; other site 941967005104 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 941967005105 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 941967005106 Walker A/P-loop; other site 941967005107 ATP binding site [chemical binding]; other site 941967005108 Q-loop/lid; other site 941967005109 ABC transporter signature motif; other site 941967005110 Walker B; other site 941967005111 D-loop; other site 941967005112 H-loop/switch region; other site 941967005113 Uncharacterized conserved protein [Function unknown]; Region: COG3743 941967005114 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 941967005115 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 941967005116 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 941967005117 TM-ABC transporter signature motif; other site 941967005118 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 941967005119 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 941967005120 TM-ABC transporter signature motif; other site 941967005121 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 941967005122 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 941967005123 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 941967005124 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 941967005125 FAD dependent oxidoreductase; Region: DAO; pfam01266 941967005126 Transcriptional regulators [Transcription]; Region: FadR; COG2186 941967005127 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941967005128 DNA-binding site [nucleotide binding]; DNA binding site 941967005129 FCD domain; Region: FCD; pfam07729 941967005130 MarR family; Region: MarR; pfam01047 941967005131 transcriptional regulator SlyA; Provisional; Region: PRK03573 941967005132 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 941967005133 F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]; Region: AtpC; COG0355 941967005134 gamma subunit interface [polypeptide binding]; other site 941967005135 epsilon subunit interface [polypeptide binding]; other site 941967005136 LBP interface [polypeptide binding]; other site 941967005137 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 941967005138 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 941967005139 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 941967005140 alpha subunit interaction interface [polypeptide binding]; other site 941967005141 Walker A motif; other site 941967005142 ATP binding site [chemical binding]; other site 941967005143 Walker B motif; other site 941967005144 inhibitor binding site; inhibition site 941967005145 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 941967005146 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 941967005147 core domain interface [polypeptide binding]; other site 941967005148 delta subunit interface [polypeptide binding]; other site 941967005149 epsilon subunit interface [polypeptide binding]; other site 941967005150 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 941967005151 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 941967005152 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 941967005153 beta subunit interaction interface [polypeptide binding]; other site 941967005154 Walker A motif; other site 941967005155 ATP binding site [chemical binding]; other site 941967005156 Walker B motif; other site 941967005157 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 941967005158 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 941967005159 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 941967005160 primosome assembly protein PriA; Validated; Region: PRK05580 941967005161 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 941967005162 ATP binding site [chemical binding]; other site 941967005163 putative Mg++ binding site [ion binding]; other site 941967005164 helicase superfamily c-terminal domain; Region: HELICc; smart00490 941967005165 nucleotide binding region [chemical binding]; other site 941967005166 ATP-binding site [chemical binding]; other site 941967005167 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 941967005168 active site 941967005169 intersubunit interactions; other site 941967005170 catalytic residue [active] 941967005171 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5468 941967005172 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 941967005173 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 941967005174 HIGH motif; other site 941967005175 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 941967005176 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 941967005177 active site 941967005178 KMSKS motif; other site 941967005179 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 941967005180 tRNA binding surface [nucleotide binding]; other site 941967005181 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 941967005182 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 941967005183 catalytic residue [active] 941967005184 Predicted membrane protein [Function unknown]; Region: COG1289 941967005185 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 941967005186 Usg protein, probable subunit of phosphoribosylanthranilate isomerase [Amino acid transport and metabolism]; Region: COG5425 941967005187 acetyl-CoA synthetase; Provisional; Region: PRK00174 941967005188 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 941967005189 active site 941967005190 CoA binding site [chemical binding]; other site 941967005191 acyl-activating enzyme (AAE) consensus motif; other site 941967005192 AMP binding site [chemical binding]; other site 941967005193 acetate binding site [chemical binding]; other site 941967005194 Uncharacterized conserved small protein [Function unknown]; Region: COG5508 941967005195 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 941967005196 heat shock protein HtpX; Provisional; Region: PRK01345 941967005197 NusB family; Region: NusB; pfam01029 941967005198 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 941967005199 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941967005200 S-adenosylmethionine binding site [chemical binding]; other site 941967005201 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5360 941967005202 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 941967005203 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 941967005204 purine monophosphate binding site [chemical binding]; other site 941967005205 dimer interface [polypeptide binding]; other site 941967005206 putative catalytic residues [active] 941967005207 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 941967005208 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 941967005209 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 941967005210 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 941967005211 Predicted membrane protein [Function unknown]; Region: COG3762 941967005212 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 941967005213 Repair protein; Region: Repair_PSII; pfam04536 941967005214 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 941967005215 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 941967005216 chorismate mutase; Provisional; Region: PRK09239 941967005217 signal recognition particle protein; Provisional; Region: PRK10867 941967005218 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 941967005219 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 941967005220 P loop; other site 941967005221 GTP binding site [chemical binding]; other site 941967005222 Signal peptide binding domain; Region: SRP_SPB; pfam02978 941967005223 lytic murein transglycosylase; Region: MltB_2; TIGR02283 941967005224 murein hydrolase B; Provisional; Region: PRK10760; cl17906 941967005225 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 941967005226 active site clefts [active] 941967005227 zinc binding site [ion binding]; other site 941967005228 dimer interface [polypeptide binding]; other site 941967005229 pyridoxamine kinase; Validated; Region: PRK05756 941967005230 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 941967005231 dimer interface [polypeptide binding]; other site 941967005232 pyridoxal binding site [chemical binding]; other site 941967005233 ATP binding site [chemical binding]; other site 941967005234 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 941967005235 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 941967005236 tetrameric interface [polypeptide binding]; other site 941967005237 NAD binding site [chemical binding]; other site 941967005238 catalytic residues [active] 941967005239 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941967005240 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941967005241 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 941967005242 dimerization interface [polypeptide binding]; other site 941967005243 Predicted membrane protein [Function unknown]; Region: COG3619 941967005244 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 941967005245 putative active site [active] 941967005246 Ap4A binding site [chemical binding]; other site 941967005247 nudix motif; other site 941967005248 putative metal binding site [ion binding]; other site 941967005249 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 941967005250 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 941967005251 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 941967005252 protein binding site [polypeptide binding]; other site 941967005253 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 941967005254 Catalytic dyad [active] 941967005255 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 941967005256 Peptidase family M23; Region: Peptidase_M23; pfam01551 941967005257 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 941967005258 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 941967005259 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 941967005260 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 941967005261 active site 941967005262 (T/H)XGH motif; other site 941967005263 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 941967005264 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 941967005265 putative catalytic cysteine [active] 941967005266 gamma-glutamyl kinase; Provisional; Region: PRK05429 941967005267 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 941967005268 nucleotide binding site [chemical binding]; other site 941967005269 homotetrameric interface [polypeptide binding]; other site 941967005270 putative phosphate binding site [ion binding]; other site 941967005271 putative allosteric binding site; other site 941967005272 PUA domain; Region: PUA; pfam01472 941967005273 GTPase CgtA; Reviewed; Region: obgE; PRK12299 941967005274 GTP1/OBG; Region: GTP1_OBG; pfam01018 941967005275 Obg GTPase; Region: Obg; cd01898 941967005276 G1 box; other site 941967005277 GTP/Mg2+ binding site [chemical binding]; other site 941967005278 Switch I region; other site 941967005279 G2 box; other site 941967005280 G3 box; other site 941967005281 Switch II region; other site 941967005282 G4 box; other site 941967005283 G5 box; other site 941967005284 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 941967005285 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 941967005286 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 941967005287 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 941967005288 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 941967005289 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 941967005290 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 941967005291 Integrase core domain; Region: rve; pfam00665 941967005292 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941967005293 non-specific DNA binding site [nucleotide binding]; other site 941967005294 salt bridge; other site 941967005295 sequence-specific DNA binding site [nucleotide binding]; other site 941967005296 Cupin domain; Region: Cupin_2; cl17218 941967005297 Methyltransferase domain; Region: Methyltransf_31; pfam13847 941967005298 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941967005299 S-adenosylmethionine binding site [chemical binding]; other site 941967005300 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 941967005301 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 941967005302 Integrase core domain; Region: rve; pfam00665 941967005303 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 941967005304 Peptidase family M23; Region: Peptidase_M23; pfam01551 941967005305 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 941967005306 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 941967005307 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 941967005308 Clp amino terminal domain; Region: Clp_N; pfam02861 941967005309 Clp amino terminal domain; Region: Clp_N; pfam02861 941967005310 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941967005311 Walker A motif; other site 941967005312 ATP binding site [chemical binding]; other site 941967005313 Walker B motif; other site 941967005314 arginine finger; other site 941967005315 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941967005316 Walker A motif; other site 941967005317 ATP binding site [chemical binding]; other site 941967005318 Walker B motif; other site 941967005319 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 941967005320 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 941967005321 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 941967005322 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941967005323 S-adenosylmethionine binding site [chemical binding]; other site 941967005324 peptide chain release factor 1; Validated; Region: prfA; PRK00591 941967005325 This domain is found in peptide chain release factors; Region: PCRF; smart00937 941967005326 RF-1 domain; Region: RF-1; pfam00472 941967005327 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 941967005328 GAF domain; Region: GAF; pfam01590 941967005329 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 941967005330 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 941967005331 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 941967005332 aspartate kinase; Reviewed; Region: PRK06635 941967005333 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 941967005334 putative nucleotide binding site [chemical binding]; other site 941967005335 putative catalytic residues [active] 941967005336 putative Mg ion binding site [ion binding]; other site 941967005337 putative aspartate binding site [chemical binding]; other site 941967005338 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 941967005339 putative allosteric regulatory site; other site 941967005340 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 941967005341 putative allosteric regulatory residue; other site 941967005342 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 941967005343 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941967005344 S-adenosylmethionine binding site [chemical binding]; other site 941967005345 EamA-like transporter family; Region: EamA; pfam00892 941967005346 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5319 941967005347 Predicted amidohydrolase [General function prediction only]; Region: COG0388 941967005348 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 941967005349 putative active site [active] 941967005350 catalytic triad [active] 941967005351 dimer interface [polypeptide binding]; other site 941967005352 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 941967005353 GSH binding site [chemical binding]; other site 941967005354 catalytic residues [active] 941967005355 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 941967005356 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 941967005357 active site 941967005358 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 941967005359 Methyltransferase domain; Region: Methyltransf_11; pfam08241 941967005360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941967005361 putative substrate translocation pore; other site 941967005362 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 941967005363 putative metal binding site [ion binding]; other site 941967005364 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 941967005365 HemY protein N-terminus; Region: HemY_N; pfam07219 941967005366 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223 941967005367 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 941967005368 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 941967005369 active site 941967005370 porphobilinogen deaminase; Region: hemC; TIGR00212 941967005371 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 941967005372 active site 941967005373 domain interfaces; other site 941967005374 UGMP family protein; Validated; Region: PRK09604 941967005375 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 941967005376 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 941967005377 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 941967005378 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 941967005379 YCII-related domain; Region: YCII; cl00999 941967005380 Uncharacterized conserved protein [Function unknown]; Region: COG2947 941967005381 Predicted methyltransferase [General function prediction only]; Region: COG3897 941967005382 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941967005383 S-adenosylmethionine binding site [chemical binding]; other site 941967005384 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 941967005385 EamA-like transporter family; Region: EamA; pfam00892 941967005386 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 941967005387 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941967005388 DNA-binding site [nucleotide binding]; DNA binding site 941967005389 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941967005390 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941967005391 homodimer interface [polypeptide binding]; other site 941967005392 catalytic residue [active] 941967005393 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 941967005394 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 941967005395 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 941967005396 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 941967005397 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 941967005398 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 941967005399 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 941967005400 active site 941967005401 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 941967005402 catalytic triad [active] 941967005403 dimer interface [polypeptide binding]; other site 941967005404 hypothetical protein; Provisional; Region: PRK05415 941967005405 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333 941967005406 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 941967005407 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 941967005408 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 941967005409 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 941967005410 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 941967005411 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 941967005412 L-aspartate oxidase; Provisional; Region: PRK06175 941967005413 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 941967005414 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 941967005415 putative SdhC subunit interface [polypeptide binding]; other site 941967005416 putative proximal heme binding site [chemical binding]; other site 941967005417 putative Iron-sulfur protein interface [polypeptide binding]; other site 941967005418 putative proximal quinone binding site; other site 941967005419 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 941967005420 Iron-sulfur protein interface; other site 941967005421 proximal quinone binding site [chemical binding]; other site 941967005422 SdhD (CybS) interface [polypeptide binding]; other site 941967005423 proximal heme binding site [chemical binding]; other site 941967005424 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 941967005425 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941967005426 Coenzyme A binding pocket [chemical binding]; other site 941967005427 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 941967005428 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 941967005429 substrate binding site [chemical binding]; other site 941967005430 ligand binding site [chemical binding]; other site 941967005431 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 941967005432 Cytosine/uracil/thiamine/allantoin permeases [Nucleotide transport and metabolism / Coenzyme metabolism]; Region: FUI1; COG1953 941967005433 Na binding site [ion binding]; other site 941967005434 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 941967005435 NIPSNAP; Region: NIPSNAP; pfam07978 941967005436 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 941967005437 dimerization interface [polypeptide binding]; other site 941967005438 putative DNA binding site [nucleotide binding]; other site 941967005439 putative Zn2+ binding site [ion binding]; other site 941967005440 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 941967005441 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 941967005442 RimM N-terminal domain; Region: RimM; pfam01782 941967005443 PRC-barrel domain; Region: PRC; pfam05239 941967005444 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 941967005445 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 941967005446 active site 941967005447 DNA binding site [nucleotide binding] 941967005448 Int/Topo IB signature motif; other site 941967005449 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 941967005450 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 941967005451 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 941967005452 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 941967005453 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 941967005454 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 941967005455 Predicted membrane protein [Function unknown]; Region: COG3686 941967005456 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 941967005457 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 941967005458 E3 interaction surface; other site 941967005459 lipoyl attachment site [posttranslational modification]; other site 941967005460 e3 binding domain; Region: E3_binding; pfam02817 941967005461 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 941967005462 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 941967005463 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 941967005464 TPP-binding site [chemical binding]; other site 941967005465 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 941967005466 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 941967005467 CoA binding domain; Region: CoA_binding; smart00881 941967005468 CoA-ligase; Region: Ligase_CoA; pfam00549 941967005469 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 941967005470 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 941967005471 CoA-ligase; Region: Ligase_CoA; pfam00549 941967005472 malate dehydrogenase; Reviewed; Region: PRK06223 941967005473 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 941967005474 NAD(P) binding site [chemical binding]; other site 941967005475 dimer interface [polypeptide binding]; other site 941967005476 tetramer (dimer of dimers) interface [polypeptide binding]; other site 941967005477 substrate binding site [chemical binding]; other site 941967005478 Predicted ATPase [General function prediction only]; Region: COG1485 941967005479 Protease inhibitor Inh; Region: Inh; pfam02974 941967005480 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 941967005481 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 941967005482 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 941967005483 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 941967005484 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 941967005485 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941967005486 FeS/SAM binding site; other site 941967005487 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 941967005488 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 941967005489 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 941967005490 intracellular septation protein A; Reviewed; Region: PRK00259 941967005491 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 941967005492 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 941967005493 active site 941967005494 8-oxo-dGMP binding site [chemical binding]; other site 941967005495 nudix motif; other site 941967005496 metal binding site [ion binding]; metal-binding site 941967005497 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941967005498 Coenzyme A binding pocket [chemical binding]; other site 941967005499 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 941967005500 heterotetramer interface [polypeptide binding]; other site 941967005501 active site pocket [active] 941967005502 cleavage site 941967005503 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 941967005504 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 941967005505 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 941967005506 DEAD/DEAH box helicase; Region: DEAD; pfam00270 941967005507 ATP binding site [chemical binding]; other site 941967005508 putative Mg++ binding site [ion binding]; other site 941967005509 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 941967005510 SEC-C motif; Region: SEC-C; pfam02810 941967005511 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 941967005512 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 941967005513 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 941967005514 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 941967005515 Sulfatase; Region: Sulfatase; pfam00884 941967005516 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941967005517 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941967005518 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 941967005519 dimerization interface [polypeptide binding]; other site 941967005520 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941967005521 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 941967005522 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941967005523 membrane-bound complex binding site; other site 941967005524 hinge residues; other site 941967005525 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 941967005526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967005527 dimer interface [polypeptide binding]; other site 941967005528 conserved gate region; other site 941967005529 putative PBP binding loops; other site 941967005530 ABC-ATPase subunit interface; other site 941967005531 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 941967005532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967005533 dimer interface [polypeptide binding]; other site 941967005534 conserved gate region; other site 941967005535 putative PBP binding loops; other site 941967005536 ABC-ATPase subunit interface; other site 941967005537 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 941967005538 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 941967005539 Walker A/P-loop; other site 941967005540 ATP binding site [chemical binding]; other site 941967005541 Q-loop/lid; other site 941967005542 ABC transporter signature motif; other site 941967005543 Walker B; other site 941967005544 D-loop; other site 941967005545 H-loop/switch region; other site 941967005546 agmatinase; Region: agmatinase; TIGR01230 941967005547 Agmatinase and related proteins; Region: Agmatinase_like_1; cd11589 941967005548 oligomer interface [polypeptide binding]; other site 941967005549 active site 941967005550 Mn binding site [ion binding]; other site 941967005551 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 941967005552 Aspartase; Region: Aspartase; cd01357 941967005553 active sites [active] 941967005554 tetramer interface [polypeptide binding]; other site 941967005555 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 941967005556 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 941967005557 Walker A/P-loop; other site 941967005558 ATP binding site [chemical binding]; other site 941967005559 Q-loop/lid; other site 941967005560 ABC transporter signature motif; other site 941967005561 Walker B; other site 941967005562 D-loop; other site 941967005563 H-loop/switch region; other site 941967005564 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 941967005565 active site 941967005566 homotetramer interface [polypeptide binding]; other site 941967005567 homodimer interface [polypeptide binding]; other site 941967005568 Transcriptional regulators [Transcription]; Region: GntR; COG1802 941967005569 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941967005570 DNA-binding site [nucleotide binding]; DNA binding site 941967005571 FCD domain; Region: FCD; pfam07729 941967005572 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 941967005573 active site 941967005574 homodimer interface [polypeptide binding]; other site 941967005575 homotetramer interface [polypeptide binding]; other site 941967005576 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941967005577 D-galactonate transporter; Region: 2A0114; TIGR00893 941967005578 putative substrate translocation pore; other site 941967005579 methionine gamma-lyase; Validated; Region: PRK07049 941967005580 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 941967005581 homodimer interface [polypeptide binding]; other site 941967005582 substrate-cofactor binding pocket; other site 941967005583 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941967005584 catalytic residue [active] 941967005585 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 941967005586 Ligand Binding Site [chemical binding]; other site 941967005587 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 941967005588 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 941967005589 dimer interface [polypeptide binding]; other site 941967005590 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941967005591 catalytic residue [active] 941967005592 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 941967005593 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 941967005594 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 941967005595 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 941967005596 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 941967005597 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 941967005598 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 941967005599 Ligand binding site [chemical binding]; other site 941967005600 Electron transfer flavoprotein domain; Region: ETF; pfam01012 941967005601 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 941967005602 Ligand Binding Site [chemical binding]; other site 941967005603 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 941967005604 active site 941967005605 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 941967005606 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 941967005607 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 941967005608 Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588 941967005609 short chain dehydrogenase; Provisional; Region: PRK05993 941967005610 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 941967005611 NADP binding site [chemical binding]; other site 941967005612 active site 941967005613 steroid binding site; other site 941967005614 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 941967005615 hypothetical protein; Validated; Region: PRK00124 941967005616 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 941967005617 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 941967005618 catalytic residues [active] 941967005619 argininosuccinate lyase; Provisional; Region: PRK00855 941967005620 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 941967005621 active sites [active] 941967005622 tetramer interface [polypeptide binding]; other site 941967005623 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 941967005624 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 941967005625 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 941967005626 active site 941967005627 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 941967005628 substrate binding site [chemical binding]; other site 941967005629 catalytic residues [active] 941967005630 dimer interface [polypeptide binding]; other site 941967005631 TIGR02302 family protein; Region: aProt_lowcomp 941967005632 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 941967005633 active site 941967005634 Methyltransferase domain; Region: Methyltransf_23; pfam13489 941967005635 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941967005636 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 941967005637 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941967005638 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941967005639 homodimer interface [polypeptide binding]; other site 941967005640 catalytic residue [active] 941967005641 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 941967005642 prephenate dehydrogenase; Validated; Region: PRK08507 941967005643 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4093 941967005644 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 941967005645 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 941967005646 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 941967005647 putative active site pocket [active] 941967005648 dimerization interface [polypeptide binding]; other site 941967005649 putative catalytic residue [active] 941967005650 YGGT family; Region: YGGT; pfam02325 941967005651 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 941967005652 dimer interface [polypeptide binding]; other site 941967005653 substrate binding site [chemical binding]; other site 941967005654 metal binding sites [ion binding]; metal-binding site 941967005655 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 941967005656 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 941967005657 putative acyl-acceptor binding pocket; other site 941967005658 Uncharacterized conserved protein [Function unknown]; Region: COG1434 941967005659 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 941967005660 putative active site [active] 941967005661 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 941967005662 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 941967005663 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 941967005664 Walker A/P-loop; other site 941967005665 ATP binding site [chemical binding]; other site 941967005666 Q-loop/lid; other site 941967005667 ABC transporter signature motif; other site 941967005668 Walker B; other site 941967005669 D-loop; other site 941967005670 H-loop/switch region; other site 941967005671 aquaporin Z; Provisional; Region: PRK05420 941967005672 amphipathic channel; other site 941967005673 Asn-Pro-Ala signature motifs; other site 941967005674 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 941967005675 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 941967005676 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 941967005677 putative catalytic site [active] 941967005678 putative phosphate binding site [ion binding]; other site 941967005679 active site 941967005680 metal binding site A [ion binding]; metal-binding site 941967005681 DNA binding site [nucleotide binding] 941967005682 putative AP binding site [nucleotide binding]; other site 941967005683 putative metal binding site B [ion binding]; other site 941967005684 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 941967005685 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 941967005686 ligand binding site [chemical binding]; other site 941967005687 flexible hinge region; other site 941967005688 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941967005689 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941967005690 active site 941967005691 phosphorylation site [posttranslational modification] 941967005692 intermolecular recognition site; other site 941967005693 dimerization interface [polypeptide binding]; other site 941967005694 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941967005695 DNA binding site [nucleotide binding] 941967005696 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 941967005697 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 941967005698 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 941967005699 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 941967005700 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 941967005701 Autotransporter beta-domain; Region: Autotransporter; smart00869 941967005702 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 941967005703 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 941967005704 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 941967005705 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 941967005706 DNA binding residues [nucleotide binding] 941967005707 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 941967005708 dimer interface [polypeptide binding]; other site 941967005709 putative metal binding site [ion binding]; other site 941967005710 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 941967005711 metal-binding site [ion binding] 941967005712 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 941967005713 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 941967005714 metal-binding site [ion binding] 941967005715 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 941967005716 Soluble P-type ATPase [General function prediction only]; Region: COG4087 941967005717 Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase) [Coenzyme metabolism]; Region: CobT; COG4547 941967005718 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 941967005719 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 941967005720 metal ion-dependent adhesion site (MIDAS); other site 941967005721 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 941967005722 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 941967005723 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 941967005724 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 941967005725 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 941967005726 HSP70 interaction site [polypeptide binding]; other site 941967005727 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 941967005728 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 941967005729 Domain of unknown function DUF21; Region: DUF21; pfam01595 941967005730 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 941967005731 Transporter associated domain; Region: CorC_HlyC; smart01091 941967005732 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 941967005733 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 941967005734 active site 941967005735 dimer interface [polypeptide binding]; other site 941967005736 metal binding site [ion binding]; metal-binding site 941967005737 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 941967005738 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 941967005739 ADP binding site [chemical binding]; other site 941967005740 magnesium binding site [ion binding]; other site 941967005741 putative shikimate binding site; other site 941967005742 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 941967005743 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 941967005744 active site 941967005745 DNA binding site [nucleotide binding] 941967005746 Int/Topo IB signature motif; other site 941967005747 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 941967005748 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 941967005749 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 941967005750 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 941967005751 CPxP motif; other site 941967005752 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 941967005753 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 941967005754 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 941967005755 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 941967005756 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 941967005757 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 941967005758 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 941967005759 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 941967005760 metal binding site [ion binding]; metal-binding site 941967005761 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 941967005762 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941967005763 NAD(P) binding site [chemical binding]; other site 941967005764 active site 941967005765 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 941967005766 Domain of unknown function (DUF4354); Region: DUF4354; pfam14263 941967005767 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 941967005768 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 941967005769 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 941967005770 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 941967005771 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941967005772 NAD(P) binding site [chemical binding]; other site 941967005773 active site 941967005774 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 941967005775 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 941967005776 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 941967005777 Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118 941967005778 NAD(P) binding site [chemical binding]; other site 941967005779 catalytic residues [active] 941967005780 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 941967005781 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 941967005782 substrate binding site [chemical binding]; other site 941967005783 oxyanion hole (OAH) forming residues; other site 941967005784 trimer interface [polypeptide binding]; other site 941967005785 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 941967005786 Coenzyme A transferase; Region: CoA_trans; smart00882 941967005787 Coenzyme A transferase; Region: CoA_trans; cl17247 941967005788 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 941967005789 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 941967005790 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 941967005791 Transcriptional regulators [Transcription]; Region: PurR; COG1609 941967005792 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 941967005793 DNA binding site [nucleotide binding] 941967005794 domain linker motif; other site 941967005795 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 941967005796 putative dimerization interface [polypeptide binding]; other site 941967005797 putative ligand binding site [chemical binding]; other site 941967005798 Protein of unknown function (DUF993); Region: DUF993; pfam06187 941967005799 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 941967005800 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 941967005801 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 941967005802 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 941967005803 zinc binding site [ion binding]; other site 941967005804 putative ligand binding site [chemical binding]; other site 941967005805 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 941967005806 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 941967005807 TM-ABC transporter signature motif; other site 941967005808 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 941967005809 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941967005810 Walker A/P-loop; other site 941967005811 ATP binding site [chemical binding]; other site 941967005812 Q-loop/lid; other site 941967005813 ABC transporter signature motif; other site 941967005814 Walker B; other site 941967005815 D-loop; other site 941967005816 H-loop/switch region; other site 941967005817 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 941967005818 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 941967005819 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 941967005820 ParB-like nuclease domain; Region: ParB; smart00470 941967005821 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 941967005822 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 941967005823 P-loop; other site 941967005824 Magnesium ion binding site [ion binding]; other site 941967005825 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 941967005826 Magnesium ion binding site [ion binding]; other site 941967005827 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 941967005828 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 941967005829 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 941967005830 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 941967005831 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 941967005832 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 941967005833 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 941967005834 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 941967005835 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 941967005836 trmE is a tRNA modification GTPase; Region: trmE; cd04164 941967005837 G1 box; other site 941967005838 G1 box; other site 941967005839 GTP/Mg2+ binding site [chemical binding]; other site 941967005840 GTP/Mg2+ binding site [chemical binding]; other site 941967005841 Switch I region; other site 941967005842 Switch I region; other site 941967005843 G2 box; other site 941967005844 G2 box; other site 941967005845 Switch II region; other site 941967005846 G3 box; other site 941967005847 G4 box; other site 941967005848 G5 box; other site 941967005849 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 941967005850 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 941967005851 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 941967005852 catalytic residues [active] 941967005853 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 941967005854 transcription termination factor Rho; Provisional; Region: rho; PRK09376 941967005855 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 941967005856 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 941967005857 RNA binding site [nucleotide binding]; other site 941967005858 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 941967005859 multimer interface [polypeptide binding]; other site 941967005860 Walker A motif; other site 941967005861 ATP binding site [chemical binding]; other site 941967005862 Walker B motif; other site 941967005863 Predicted membrane protein [Function unknown]; Region: COG1981 941967005864 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 941967005865 substrate binding site [chemical binding]; other site 941967005866 active site 941967005867 PEP synthetase regulatory protein; Provisional; Region: PRK05339 941967005868 Maf-like protein; Reviewed; Region: PRK00078 941967005869 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 941967005870 active site 941967005871 dimer interface [polypeptide binding]; other site 941967005872 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 941967005873 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 941967005874 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 941967005875 shikimate binding site; other site 941967005876 NAD(P) binding site [chemical binding]; other site 941967005877 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 941967005878 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 941967005879 CoA-binding site [chemical binding]; other site 941967005880 ATP-binding [chemical binding]; other site 941967005881 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 941967005882 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 941967005883 active site 941967005884 catalytic site [active] 941967005885 substrate binding site [chemical binding]; other site 941967005886 preprotein translocase subunit SecB; Validated; Region: PRK05751 941967005887 SecA binding site; other site 941967005888 Preprotein binding site; other site 941967005889 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 941967005890 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 941967005891 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 941967005892 MltA specific insert domain; Region: MltA; pfam03562 941967005893 3D domain; Region: 3D; pfam06725 941967005894 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 941967005895 Smr domain; Region: Smr; pfam01713 941967005896 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 941967005897 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941967005898 sequence-specific DNA binding site [nucleotide binding]; other site 941967005899 salt bridge; other site 941967005900 Protein of unknown function (DUF1402); Region: DUF1402; pfam07182 941967005901 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 941967005902 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941967005903 Walker A motif; other site 941967005904 ATP binding site [chemical binding]; other site 941967005905 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 941967005906 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 941967005907 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 941967005908 active site 941967005909 HslU subunit interaction site [polypeptide binding]; other site 941967005910 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 941967005911 putative active site pocket [active] 941967005912 4-fold oligomerization interface [polypeptide binding]; other site 941967005913 metal binding residues [ion binding]; metal-binding site 941967005914 3-fold/trimer interface [polypeptide binding]; other site 941967005915 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 941967005916 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 941967005917 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 941967005918 putative active site [active] 941967005919 oxyanion strand; other site 941967005920 catalytic triad [active] 941967005921 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 941967005922 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 941967005923 catalytic residues [active] 941967005924 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 941967005925 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 941967005926 substrate binding site [chemical binding]; other site 941967005927 glutamase interaction surface [polypeptide binding]; other site 941967005928 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 941967005929 metal binding site [ion binding]; metal-binding site 941967005930 pantothenate kinase; Provisional; Region: PRK05439 941967005931 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 941967005932 ATP-binding site [chemical binding]; other site 941967005933 CoA-binding site [chemical binding]; other site 941967005934 Mg2+-binding site [ion binding]; other site 941967005935 hypothetical protein; Provisional; Region: PRK09256 941967005936 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 941967005937 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 941967005938 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 941967005939 active site 941967005940 substrate-binding site [chemical binding]; other site 941967005941 metal-binding site [ion binding] 941967005942 ATP binding site [chemical binding]; other site 941967005943 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941967005944 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941967005945 active site 941967005946 phosphorylation site [posttranslational modification] 941967005947 intermolecular recognition site; other site 941967005948 dimerization interface [polypeptide binding]; other site 941967005949 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941967005950 DNA binding site [nucleotide binding] 941967005951 Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755 941967005952 Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756 941967005953 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941967005954 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941967005955 dimerization interface [polypeptide binding]; other site 941967005956 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941967005957 dimer interface [polypeptide binding]; other site 941967005958 phosphorylation site [posttranslational modification] 941967005959 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941967005960 ATP binding site [chemical binding]; other site 941967005961 Mg2+ binding site [ion binding]; other site 941967005962 G-X-G motif; other site 941967005963 Serine kinase of the HPr protein, regulates carbohydrate metabolism [Signal transduction mechanisms]; Region: HprK; COG1493 941967005964 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 941967005965 Hpr binding site; other site 941967005966 active site 941967005967 homohexamer subunit interaction site [polypeptide binding]; other site 941967005968 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 941967005969 active pocket/dimerization site; other site 941967005970 active site 941967005971 phosphorylation site [posttranslational modification] 941967005972 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 941967005973 dimerization domain swap beta strand [polypeptide binding]; other site 941967005974 regulatory protein interface [polypeptide binding]; other site 941967005975 active site 941967005976 regulatory phosphorylation site [posttranslational modification]; other site 941967005977 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 941967005978 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 941967005979 homotetramer interface [polypeptide binding]; other site 941967005980 ligand binding site [chemical binding]; other site 941967005981 catalytic site [active] 941967005982 NAD binding site [chemical binding]; other site 941967005983 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 941967005984 PAS fold; Region: PAS_7; pfam12860 941967005985 PAS fold; Region: PAS_7; pfam12860 941967005986 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941967005987 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941967005988 dimer interface [polypeptide binding]; other site 941967005989 phosphorylation site [posttranslational modification] 941967005990 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941967005991 ATP binding site [chemical binding]; other site 941967005992 Mg2+ binding site [ion binding]; other site 941967005993 G-X-G motif; other site 941967005994 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 941967005995 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 941967005996 Phosphotransferase enzyme family; Region: APH; pfam01636 941967005997 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 941967005998 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 941967005999 Substrate binding site; other site 941967006000 metal-binding site 941967006001 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 941967006002 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 941967006003 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 941967006004 Part of AAA domain; Region: AAA_19; pfam13245 941967006005 Family description; Region: UvrD_C_2; pfam13538 941967006006 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 941967006007 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 941967006008 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 941967006009 catalytic residues [active] 941967006010 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 941967006011 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 941967006012 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 941967006013 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 941967006014 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 941967006015 substrate binding site [chemical binding]; other site 941967006016 active site 941967006017 catalytic residues [active] 941967006018 heterodimer interface [polypeptide binding]; other site 941967006019 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 941967006020 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 941967006021 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941967006022 catalytic residue [active] 941967006023 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 941967006024 active site 941967006025 Uncharacterized conserved protein [Function unknown]; Region: COG1434 941967006026 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 941967006027 putative active site [active] 941967006028 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 941967006029 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 941967006030 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 941967006031 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 941967006032 benzoate transporter; Region: benE; TIGR00843 941967006033 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 941967006034 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 941967006035 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 941967006036 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 941967006037 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 941967006038 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 941967006039 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 941967006040 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 941967006041 23S rRNA binding site [nucleotide binding]; other site 941967006042 L21 binding site [polypeptide binding]; other site 941967006043 L13 binding site [polypeptide binding]; other site 941967006044 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 941967006045 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 941967006046 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 941967006047 dimer interface [polypeptide binding]; other site 941967006048 motif 1; other site 941967006049 active site 941967006050 motif 2; other site 941967006051 motif 3; other site 941967006052 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 941967006053 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 941967006054 putative tRNA-binding site [nucleotide binding]; other site 941967006055 B3/4 domain; Region: B3_4; pfam03483 941967006056 tRNA synthetase B5 domain; Region: B5; smart00874 941967006057 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 941967006058 dimer interface [polypeptide binding]; other site 941967006059 motif 1; other site 941967006060 motif 3; other site 941967006061 motif 2; other site 941967006062 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 941967006063 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 941967006064 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 941967006065 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 941967006066 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 941967006067 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 941967006068 nucleotide binding site [chemical binding]; other site 941967006069 NEF interaction site [polypeptide binding]; other site 941967006070 SBD interface [polypeptide binding]; other site 941967006071 chaperone protein DnaJ; Provisional; Region: PRK10767 941967006072 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 941967006073 HSP70 interaction site [polypeptide binding]; other site 941967006074 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 941967006075 substrate binding site [polypeptide binding]; other site 941967006076 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 941967006077 Zn binding sites [ion binding]; other site 941967006078 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 941967006079 dimer interface [polypeptide binding]; other site 941967006080 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941967006081 S-adenosylmethionine binding site [chemical binding]; other site 941967006082 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 941967006083 active site 941967006084 dimer interface [polypeptide binding]; other site 941967006085 Uncharacterized conserved protein [Function unknown]; Region: COG5470 941967006086 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 941967006087 glutathione synthetase; Provisional; Region: PRK05246 941967006088 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 941967006089 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 941967006090 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 941967006091 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 941967006092 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941967006093 Walker A motif; other site 941967006094 ATP binding site [chemical binding]; other site 941967006095 Walker B motif; other site 941967006096 arginine finger; other site 941967006097 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 941967006098 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 941967006099 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 941967006100 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 941967006101 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 941967006102 PBP superfamily domain; Region: PBP_like_2; pfam12849 941967006103 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 941967006104 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 941967006105 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967006106 dimer interface [polypeptide binding]; other site 941967006107 conserved gate region; other site 941967006108 putative PBP binding loops; other site 941967006109 ABC-ATPase subunit interface; other site 941967006110 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 941967006111 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 941967006112 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967006113 dimer interface [polypeptide binding]; other site 941967006114 conserved gate region; other site 941967006115 putative PBP binding loops; other site 941967006116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 941967006117 ABC-ATPase subunit interface; other site 941967006118 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 941967006119 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 941967006120 Walker A/P-loop; other site 941967006121 ATP binding site [chemical binding]; other site 941967006122 Q-loop/lid; other site 941967006123 ABC transporter signature motif; other site 941967006124 Walker B; other site 941967006125 D-loop; other site 941967006126 H-loop/switch region; other site 941967006127 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 941967006128 PhoU domain; Region: PhoU; pfam01895 941967006129 PhoU domain; Region: PhoU; pfam01895 941967006130 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 941967006131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941967006132 active site 941967006133 phosphorylation site [posttranslational modification] 941967006134 intermolecular recognition site; other site 941967006135 dimerization interface [polypeptide binding]; other site 941967006136 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941967006137 DNA binding site [nucleotide binding] 941967006138 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 941967006139 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 941967006140 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 941967006141 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 941967006142 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 941967006143 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 941967006144 dimerization interface [polypeptide binding]; other site 941967006145 DPS ferroxidase diiron center [ion binding]; other site 941967006146 ion pore; other site 941967006147 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 941967006148 Glycoprotease family; Region: Peptidase_M22; pfam00814 941967006149 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 941967006150 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941967006151 Coenzyme A binding pocket [chemical binding]; other site 941967006152 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 941967006153 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 941967006154 putative acyl-acceptor binding pocket; other site 941967006155 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 941967006156 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 941967006157 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941967006158 FeS/SAM binding site; other site 941967006159 TRAM domain; Region: TRAM; cl01282 941967006160 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 941967006161 PhoH-like protein; Region: PhoH; pfam02562 941967006162 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 941967006163 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 941967006164 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 941967006165 Transporter associated domain; Region: CorC_HlyC; smart01091 941967006166 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 941967006167 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 941967006168 putative active site [active] 941967006169 catalytic triad [active] 941967006170 putative dimer interface [polypeptide binding]; other site 941967006171 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 941967006172 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941967006173 non-specific DNA binding site [nucleotide binding]; other site 941967006174 salt bridge; other site 941967006175 sequence-specific DNA binding site [nucleotide binding]; other site 941967006176 S-adenosylmethionine synthetase; Validated; Region: PRK05250 941967006177 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 941967006178 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 941967006179 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 941967006180 Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only]; Region: COG0220 941967006181 ribosome maturation protein RimP; Reviewed; Region: PRK00092 941967006182 Sm and related proteins; Region: Sm_like; cl00259 941967006183 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 941967006184 putative oligomer interface [polypeptide binding]; other site 941967006185 putative RNA binding site [nucleotide binding]; other site 941967006186 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 941967006187 NusA N-terminal domain; Region: NusA_N; pfam08529 941967006188 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 941967006189 RNA binding site [nucleotide binding]; other site 941967006190 homodimer interface [polypeptide binding]; other site 941967006191 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 941967006192 G-X-X-G motif; other site 941967006193 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 941967006194 G-X-X-G motif; other site 941967006195 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 941967006196 hypothetical protein; Provisional; Region: PRK09190 941967006197 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 941967006198 putative RNA binding cleft [nucleotide binding]; other site 941967006199 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 941967006200 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 941967006201 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 941967006202 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 941967006203 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 941967006204 G1 box; other site 941967006205 putative GEF interaction site [polypeptide binding]; other site 941967006206 GTP/Mg2+ binding site [chemical binding]; other site 941967006207 Switch I region; other site 941967006208 G2 box; other site 941967006209 G3 box; other site 941967006210 Switch II region; other site 941967006211 G4 box; other site 941967006212 G5 box; other site 941967006213 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 941967006214 Translation-initiation factor 2; Region: IF-2; pfam11987 941967006215 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 941967006216 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 941967006217 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 941967006218 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 941967006219 RNA binding site [nucleotide binding]; other site 941967006220 active site 941967006221 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 941967006222 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 941967006223 16S/18S rRNA binding site [nucleotide binding]; other site 941967006224 S13e-L30e interaction site [polypeptide binding]; other site 941967006225 25S rRNA binding site [nucleotide binding]; other site 941967006226 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 941967006227 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 941967006228 RNase E interface [polypeptide binding]; other site 941967006229 trimer interface [polypeptide binding]; other site 941967006230 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 941967006231 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 941967006232 RNase E interface [polypeptide binding]; other site 941967006233 trimer interface [polypeptide binding]; other site 941967006234 active site 941967006235 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 941967006236 putative nucleic acid binding region [nucleotide binding]; other site 941967006237 G-X-X-G motif; other site 941967006238 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 941967006239 RNA binding site [nucleotide binding]; other site 941967006240 domain interface; other site 941967006241 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 941967006242 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 941967006243 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 941967006244 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505 941967006245 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 941967006246 NAD binding site [chemical binding]; other site 941967006247 homotetramer interface [polypeptide binding]; other site 941967006248 homodimer interface [polypeptide binding]; other site 941967006249 substrate binding site [chemical binding]; other site 941967006250 active site 941967006251 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 941967006252 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 941967006253 dimer interface [polypeptide binding]; other site 941967006254 active site 941967006255 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 941967006256 active site 1 [active] 941967006257 dimer interface [polypeptide binding]; other site 941967006258 active site 2 [active] 941967006259 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 941967006260 metal binding site 2 [ion binding]; metal-binding site 941967006261 putative DNA binding helix; other site 941967006262 metal binding site 1 [ion binding]; metal-binding site 941967006263 dimer interface [polypeptide binding]; other site 941967006264 structural Zn2+ binding site [ion binding]; other site 941967006265 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 941967006266 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 941967006267 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 941967006268 Bacterial SH3 domain; Region: SH3_4; pfam06347 941967006269 Bacterial SH3 domain; Region: SH3_4; pfam06347 941967006270 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 941967006271 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 941967006272 dimerization interface [polypeptide binding]; other site 941967006273 ligand binding site [chemical binding]; other site 941967006274 NADP binding site [chemical binding]; other site 941967006275 catalytic site [active] 941967006276 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 941967006277 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 941967006278 NlpC/P60 family; Region: NLPC_P60; cl17555 941967006279 Transcriptional regulators [Transcription]; Region: MarR; COG1846 941967006280 MarR family; Region: MarR; pfam01047 941967006281 multifunctional aminopeptidase A; Provisional; Region: PRK00913 941967006282 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 941967006283 interface (dimer of trimers) [polypeptide binding]; other site 941967006284 Substrate-binding/catalytic site; other site 941967006285 Zn-binding sites [ion binding]; other site 941967006286 Flp/Fap pilin component; Region: Flp_Fap; cl01585 941967006287 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 941967006288 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 941967006289 DNA binding site [nucleotide binding] 941967006290 catalytic residue [active] 941967006291 H2TH interface [polypeptide binding]; other site 941967006292 putative catalytic residues [active] 941967006293 turnover-facilitating residue; other site 941967006294 intercalation triad [nucleotide binding]; other site 941967006295 8OG recognition residue [nucleotide binding]; other site 941967006296 putative reading head residues; other site 941967006297 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 941967006298 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 941967006299 enoyl-CoA hydratase; Provisional; Region: PRK05862 941967006300 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 941967006301 substrate binding site [chemical binding]; other site 941967006302 oxyanion hole (OAH) forming residues; other site 941967006303 trimer interface [polypeptide binding]; other site 941967006304 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 941967006305 replication initiation protein RepC; Provisional; Region: PRK13824 941967006306 Replication protein C N-terminal domain; Region: RP-C; pfam03428 941967006307 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 941967006308 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 941967006309 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 941967006310 substrate binding site [chemical binding]; other site 941967006311 dimer interface [polypeptide binding]; other site 941967006312 ATP binding site [chemical binding]; other site 941967006313 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 941967006314 active site 941967006315 tetramer interface [polypeptide binding]; other site 941967006316 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 941967006317 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 941967006318 TM-ABC transporter signature motif; other site 941967006319 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 941967006320 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 941967006321 TM-ABC transporter signature motif; other site 941967006322 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 941967006323 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 941967006324 Walker A/P-loop; other site 941967006325 ATP binding site [chemical binding]; other site 941967006326 Q-loop/lid; other site 941967006327 ABC transporter signature motif; other site 941967006328 Walker B; other site 941967006329 D-loop; other site 941967006330 H-loop/switch region; other site 941967006331 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 941967006332 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 941967006333 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 941967006334 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 941967006335 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 941967006336 Predicted secreted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5664 941967006337 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 941967006338 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 941967006339 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 941967006340 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 941967006341 putative NAD(P) binding site [chemical binding]; other site 941967006342 active site 941967006343 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 941967006344 hydrophobic substrate binding pocket; other site 941967006345 Isochorismatase family; Region: Isochorismatase; pfam00857 941967006346 active site 941967006347 conserved cis-peptide bond; other site 941967006348 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 941967006349 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 941967006350 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 941967006351 acyl-activating enzyme (AAE) consensus motif; other site 941967006352 active site 941967006353 AMP binding site [chemical binding]; other site 941967006354 substrate binding site [chemical binding]; other site 941967006355 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 941967006356 isochorismate synthases; Region: isochor_syn; TIGR00543 941967006357 Condensation domain; Region: Condensation; pfam00668 941967006358 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 941967006359 bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108 941967006360 Moco binding site; other site 941967006361 metal coordination site [ion binding]; other site 941967006362 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 941967006363 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 941967006364 pentapeptide MXKDX repeat protein; Region: penta_MxKDx; TIGR02953 941967006365 RNA polymerase sigma factor; Provisional; Region: PRK12539 941967006366 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941967006367 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 941967006368 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4944 941967006369 Transcriptional regulators [Transcription]; Region: FadR; COG2186 941967006370 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941967006371 DNA-binding site [nucleotide binding]; DNA binding site 941967006372 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 941967006373 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 941967006374 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 941967006375 putative ligand binding site [chemical binding]; other site 941967006376 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 941967006377 TM-ABC transporter signature motif; other site 941967006378 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 941967006379 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 941967006380 TM-ABC transporter signature motif; other site 941967006381 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 941967006382 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 941967006383 Walker A/P-loop; other site 941967006384 ATP binding site [chemical binding]; other site 941967006385 Q-loop/lid; other site 941967006386 ABC transporter signature motif; other site 941967006387 Walker B; other site 941967006388 D-loop; other site 941967006389 H-loop/switch region; other site 941967006390 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 941967006391 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 941967006392 Walker A/P-loop; other site 941967006393 ATP binding site [chemical binding]; other site 941967006394 Q-loop/lid; other site 941967006395 ABC transporter signature motif; other site 941967006396 Walker B; other site 941967006397 D-loop; other site 941967006398 H-loop/switch region; other site 941967006399 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 941967006400 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 941967006401 active site 941967006402 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 941967006403 classical (c) SDRs; Region: SDR_c; cd05233 941967006404 NAD(P) binding site [chemical binding]; other site 941967006405 active site 941967006406 classical (c) SDRs; Region: SDR_c; cd05233 941967006407 NAD(P) binding site [chemical binding]; other site 941967006408 active site 941967006409 potential frameshift: common BLAST hit: gi|376270582|ref|YP_005113627.1| dehydrogenase E1 component 941967006410 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 941967006411 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 941967006412 tetramer interface [polypeptide binding]; other site 941967006413 TPP-binding site [chemical binding]; other site 941967006414 heterodimer interface [polypeptide binding]; other site 941967006415 phosphorylation loop region [posttranslational modification] 941967006416 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 941967006417 PYR/PP interface [polypeptide binding]; other site 941967006418 TPP binding site [chemical binding]; other site 941967006419 dimer interface [polypeptide binding]; other site 941967006420 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 941967006421 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 941967006422 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 941967006423 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 941967006424 E3 interaction surface; other site 941967006425 lipoyl attachment site [posttranslational modification]; other site 941967006426 e3 binding domain; Region: E3_binding; pfam02817 941967006427 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 941967006428 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 941967006429 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 941967006430 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 941967006431 shikimate binding site; other site 941967006432 NAD(P) binding site [chemical binding]; other site 941967006433 magnesium-transporting ATPase; Provisional; Region: PRK15122 941967006434 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 941967006435 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 941967006436 Soluble P-type ATPase [General function prediction only]; Region: COG4087 941967006437 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 941967006438 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 941967006439 MgtC family; Region: MgtC; pfam02308 941967006440 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941967006441 ATP binding site [chemical binding]; other site 941967006442 Mg2+ binding site [ion binding]; other site 941967006443 G-X-G motif; other site 941967006444 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 941967006445 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941967006446 active site 941967006447 phosphorylation site [posttranslational modification] 941967006448 intermolecular recognition site; other site 941967006449 dimerization interface [polypeptide binding]; other site 941967006450 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 941967006451 dimerization interface [polypeptide binding]; other site 941967006452 DNA binding residues [nucleotide binding] 941967006453 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941967006454 Response regulator receiver domain; Region: Response_reg; pfam00072 941967006455 active site 941967006456 phosphorylation site [posttranslational modification] 941967006457 intermolecular recognition site; other site 941967006458 dimerization interface [polypeptide binding]; other site 941967006459 N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: HutG; COG3741 941967006460 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 941967006461 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 941967006462 active site 941967006463 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 941967006464 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 941967006465 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 941967006466 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 941967006467 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 941967006468 putative dimer interface [polypeptide binding]; other site 941967006469 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 941967006470 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 941967006471 tetramer interface [polypeptide binding]; other site 941967006472 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941967006473 catalytic residue [active] 941967006474 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 941967006475 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 941967006476 active site 941967006477 dimer interface [polypeptide binding]; other site 941967006478 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 941967006479 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 941967006480 active site 941967006481 FMN binding site [chemical binding]; other site 941967006482 substrate binding site [chemical binding]; other site 941967006483 3Fe-4S cluster binding site [ion binding]; other site 941967006484 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 941967006485 domain interface; other site 941967006486 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 941967006487 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 941967006488 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 941967006489 active site 941967006490 catalytic triad [active] 941967006491 oxyanion hole [active] 941967006492 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 941967006493 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 941967006494 ligand binding site [chemical binding]; other site 941967006495 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 941967006496 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 941967006497 ATP binding site [chemical binding]; other site 941967006498 Walker A motif; other site 941967006499 hexamer interface [polypeptide binding]; other site 941967006500 Walker B motif; other site 941967006501 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 941967006502 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 941967006503 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 941967006504 VirB7 interaction site; other site 941967006505 Type IV secretory pathway, component VirB8 [Intracellular trafficking and secretion]; Region: VirB8; COG3736 941967006506 Type IV secretory pathway, VirB6 components [Intracellular trafficking and secretion]; Region: VirB6; COG3704 941967006507 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 941967006508 Type IV secretion system proteins; Region: T4SS; pfam07996 941967006509 Type IV secretory pathway, VirB4 components [Intracellular trafficking and secretion]; Region: VirB4; COG3451 941967006510 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 941967006511 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 941967006512 TrbC/VIRB2 family; Region: TrbC; cl01583 941967006513 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 941967006514 N-acetyl-D-glucosamine binding site [chemical binding]; other site 941967006515 catalytic residue [active] 941967006516 lytic murein transglycosylase; Region: MltB_2; TIGR02283 941967006517 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 941967006518 N-acetyl-D-glucosamine binding site [chemical binding]; other site 941967006519 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 941967006520 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 941967006521 active site 941967006522 tetramer interface; other site 941967006523 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5338 941967006524 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 941967006525 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 941967006526 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 941967006527 putative active site [active] 941967006528 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 941967006529 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 941967006530 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 941967006531 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 941967006532 ferrochelatase; Reviewed; Region: hemH; PRK00035 941967006533 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 941967006534 C-terminal domain interface [polypeptide binding]; other site 941967006535 active site 941967006536 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 941967006537 active site 941967006538 N-terminal domain interface [polypeptide binding]; other site 941967006539 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 941967006540 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 941967006541 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 941967006542 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 941967006543 hypothetical protein; Provisional; Region: PRK07546 941967006544 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 941967006545 substrate-cofactor binding pocket; other site 941967006546 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941967006547 homodimer interface [polypeptide binding]; other site 941967006548 catalytic residue [active] 941967006549 aminodeoxychorismate synthase; Provisional; Region: PRK07508 941967006550 chorismate binding enzyme; Region: Chorismate_bind; cl10555 941967006551 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 941967006552 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 941967006553 active site 941967006554 Zn binding site [ion binding]; other site 941967006555 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 941967006556 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941967006557 active site 941967006558 phosphorylation site [posttranslational modification] 941967006559 intermolecular recognition site; other site 941967006560 dimerization interface [polypeptide binding]; other site 941967006561 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941967006562 Walker A motif; other site 941967006563 ATP binding site [chemical binding]; other site 941967006564 Walker B motif; other site 941967006565 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 941967006566 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 941967006567 Bacterial protein of unknown function (DUF882); Region: Peptidase_M15_2; pfam05951 941967006568 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 941967006569 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 941967006570 active site 941967006571 intersubunit interface [polypeptide binding]; other site 941967006572 catalytic residue [active] 941967006573 Protein of unknown function (DUF3380); Region: DUF3380; pfam11860 941967006574 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 941967006575 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 941967006576 active site residue [active] 941967006577 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 941967006578 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 941967006579 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967006580 dimer interface [polypeptide binding]; other site 941967006581 conserved gate region; other site 941967006582 putative PBP binding loops; other site 941967006583 ABC-ATPase subunit interface; other site 941967006584 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 941967006585 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941967006586 Walker A/P-loop; other site 941967006587 ATP binding site [chemical binding]; other site 941967006588 Q-loop/lid; other site 941967006589 ABC transporter signature motif; other site 941967006590 Walker B; other site 941967006591 D-loop; other site 941967006592 H-loop/switch region; other site 941967006593 TOBE domain; Region: TOBE; cl01440 941967006594 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 941967006595 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 941967006596 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 941967006597 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941967006598 LysR family transcriptional regulator; Provisional; Region: PRK14997 941967006599 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 941967006600 putative effector binding pocket; other site 941967006601 dimerization interface [polypeptide binding]; other site 941967006602 amidase; Provisional; Region: PRK08310 941967006603 indole-3-acetamide amidohydrolase; Region: PLN02722 941967006604 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 941967006605 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 941967006606 dimer interface [polypeptide binding]; other site 941967006607 active site 941967006608 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 941967006609 catalytic residues [active] 941967006610 substrate binding site [chemical binding]; other site 941967006611 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 941967006612 Chain length determinant protein; Region: Wzz; pfam02706 941967006613 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 941967006614 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 941967006615 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 941967006616 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 941967006617 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 941967006618 active site 941967006619 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 941967006620 O-Antigen ligase; Region: Wzy_C; pfam04932 941967006621 potential frameshift: common BLAST hit: gi|376278097|ref|YP_005108130.1| Gfo/Idh/MocA family oxidoreductase 941967006622 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 941967006623 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 941967006624 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 941967006625 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 941967006626 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 941967006627 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG0362 941967006628 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 941967006629 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 941967006630 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 941967006631 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941967006632 Walker A/P-loop; other site 941967006633 ATP binding site [chemical binding]; other site 941967006634 Q-loop/lid; other site 941967006635 ABC transporter signature motif; other site 941967006636 Walker B; other site 941967006637 D-loop; other site 941967006638 H-loop/switch region; other site 941967006639 TOBE domain; Region: TOBE_2; pfam08402 941967006640 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 941967006641 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967006642 dimer interface [polypeptide binding]; other site 941967006643 conserved gate region; other site 941967006644 putative PBP binding loops; other site 941967006645 ABC-ATPase subunit interface; other site 941967006646 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967006647 dimer interface [polypeptide binding]; other site 941967006648 conserved gate region; other site 941967006649 putative PBP binding loops; other site 941967006650 ABC-ATPase subunit interface; other site 941967006651 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 941967006652 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 941967006653 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 941967006654 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941967006655 putative substrate translocation pore; other site 941967006656 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 941967006657 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 941967006658 HlyD family secretion protein; Region: HlyD_3; pfam13437 941967006659 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941967006660 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941967006661 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 941967006662 Autoinducer binding domain; Region: Autoind_bind; pfam03472 941967006663 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 941967006664 DNA binding residues [nucleotide binding] 941967006665 dimerization interface [polypeptide binding]; other site 941967006666 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377 941967006667 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 941967006668 FliG C-terminal domain; Region: FliG_C; pfam01706 941967006669 Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536 941967006670 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 941967006671 Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868 941967006672 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 941967006673 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 941967006674 flagellar motor protein MotA; Validated; Region: PRK09110 941967006675 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 941967006676 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 941967006677 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642 941967006678 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 941967006679 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 941967006680 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002 941967006681 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 941967006682 Walker A motif; other site 941967006683 ATP binding site [chemical binding]; other site 941967006684 Walker B motif; other site 941967006685 PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389 941967006686 active site 941967006687 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 941967006688 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 941967006689 Ligand binding site; other site 941967006690 Putative Catalytic site; other site 941967006691 DXD motif; other site 941967006692 Peptidase family M48; Region: Peptidase_M48; cl12018 941967006693 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807 941967006694 putative active site [active] 941967006695 YdjC motif; other site 941967006696 Mg binding site [ion binding]; other site 941967006697 putative homodimer interface [polypeptide binding]; other site 941967006698 potential frameshift: common BLAST hit: gi|376278123|ref|YP_005108156.1| dolichyl-phosphate-mannose-protein mannosyltransferase family 941967006699 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 941967006700 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 941967006701 Helix-turn-helix domain; Region: HTH_18; pfam12833 941967006702 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941967006703 Transposase; Region: HTH_Tnp_1; cl17663 941967006704 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941967006705 D-galactonate transporter; Region: 2A0114; TIGR00893 941967006706 putative substrate translocation pore; other site 941967006707 putative aldolase; Validated; Region: PRK08130 941967006708 intersubunit interface [polypeptide binding]; other site 941967006709 active site 941967006710 Zn2+ binding site [ion binding]; other site 941967006711 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941967006712 NAD(P) binding site [chemical binding]; other site 941967006713 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 941967006714 active site 941967006715 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 941967006716 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 941967006717 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 941967006718 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 941967006719 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 941967006720 Metal-binding active site; metal-binding site 941967006721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 941967006722 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 941967006723 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003 941967006724 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782 941967006725 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 941967006726 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 941967006727 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790 941967006728 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 941967006729 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 941967006730 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK06005 941967006731 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 941967006732 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 941967006733 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 941967006734 Uncharacterized conserved protein [Function unknown]; Region: COG3334 941967006735 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 941967006736 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 941967006737 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 941967006738 FliP family; Region: FliP; cl00593 941967006739 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4893 941967006740 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941967006741 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941967006742 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 941967006743 putative dimerization interface [polypeptide binding]; other site 941967006744 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 941967006745 CoA-transferase family III; Region: CoA_transf_3; pfam02515 941967006746 Uncharacterized conserved protein [Function unknown]; Region: COG3777 941967006747 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 941967006748 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 941967006749 active site 2 [active] 941967006750 active site 1 [active] 941967006751 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 941967006752 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 941967006753 potential frameshift: common BLAST hit: gi|189022382|ref|YP_001932123.1| outermembrane transporter 941967006754 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 941967006755 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 941967006756 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 941967006757 Autotransporter beta-domain; Region: Autotransporter; pfam03797 941967006758 Cytochrome c2 [Energy production and conversion]; Region: COG3474 941967006759 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841 941967006760 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 941967006761 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941967006762 DNA-binding site [nucleotide binding]; DNA binding site 941967006763 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 941967006764 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941967006765 transcriptional activator TtdR; Provisional; Region: PRK09801 941967006766 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 941967006767 putative effector binding pocket; other site 941967006768 dimerization interface [polypeptide binding]; other site 941967006769 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 941967006770 FAD binding domain; Region: FAD_binding_4; pfam01565 941967006771 FAD binding domain; Region: FAD_binding_4; pfam01565 941967006772 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 941967006773 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 941967006774 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 941967006775 Cysteine-rich domain; Region: CCG; pfam02754 941967006776 Cysteine-rich domain; Region: CCG; pfam02754 941967006777 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 941967006778 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 941967006779 active site 941967006780 catalytic tetrad [active] 941967006781 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 941967006782 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 941967006783 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 941967006784 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 941967006785 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 941967006786 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 941967006787 dimer interface [polypeptide binding]; other site 941967006788 motif 1; other site 941967006789 motif 2; other site 941967006790 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 941967006791 active site 941967006792 motif 3; other site 941967006793 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 941967006794 anticodon binding site; other site 941967006795 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295 941967006796 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 941967006797 motif 1; other site 941967006798 dimer interface [polypeptide binding]; other site 941967006799 active site 941967006800 motif 2; other site 941967006801 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 941967006802 active site 941967006803 motif 3; other site 941967006804 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583 941967006805 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 941967006806 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 941967006807 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941967006808 putative substrate translocation pore; other site 941967006809 Predicted membrane protein [Function unknown]; Region: COG2259 941967006810 fumarate hydratase; Reviewed; Region: fumC; PRK00485 941967006811 Class II fumarases; Region: Fumarase_classII; cd01362 941967006812 active site 941967006813 tetramer interface [polypeptide binding]; other site 941967006814 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 941967006815 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 941967006816 ring oligomerisation interface [polypeptide binding]; other site 941967006817 ATP/Mg binding site [chemical binding]; other site 941967006818 stacking interactions; other site 941967006819 hinge regions; other site 941967006820 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 941967006821 oligomerisation interface [polypeptide binding]; other site 941967006822 mobile loop; other site 941967006823 roof hairpin; other site 941967006824 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 941967006825 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 941967006826 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941967006827 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 941967006828 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 941967006829 active site 941967006830 Riboflavin kinase; Region: Flavokinase; smart00904 941967006831 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 941967006832 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 941967006833 active site 941967006834 HIGH motif; other site 941967006835 nucleotide binding site [chemical binding]; other site 941967006836 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 941967006837 active site 941967006838 KMSKS motif; other site 941967006839 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 941967006840 tRNA binding surface [nucleotide binding]; other site 941967006841 anticodon binding site; other site 941967006842 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 941967006843 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 941967006844 nucleoside/Zn binding site; other site 941967006845 dimer interface [polypeptide binding]; other site 941967006846 catalytic motif [active] 941967006847 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 941967006848 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 941967006849 RNA binding surface [nucleotide binding]; other site 941967006850 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 941967006851 active site 941967006852 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 941967006853 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941967006854 S-adenosylmethionine binding site [chemical binding]; other site 941967006855 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 941967006856 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 941967006857 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 941967006858 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 941967006859 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 941967006860 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 941967006861 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 941967006862 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 941967006863 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 941967006864 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 941967006865 TrkA-N domain; Region: TrkA_N; pfam02254 941967006866 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 941967006867 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 941967006868 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 941967006869 active site 941967006870 Domain of unknown function (DUF4170); Region: DUF4170; pfam13773 941967006871 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 941967006872 putative acyl-acceptor binding pocket; other site 941967006873 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 941967006874 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 941967006875 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 941967006876 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 941967006877 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 941967006878 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3908 941967006879 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 941967006880 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941967006881 ATP binding site [chemical binding]; other site 941967006882 Mg2+ binding site [ion binding]; other site 941967006883 G-X-G motif; other site 941967006884 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 941967006885 ATP binding site [chemical binding]; other site 941967006886 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 941967006887 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941967006888 putative substrate translocation pore; other site 941967006889 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 941967006890 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 941967006891 active site 941967006892 Transcriptional regulator [Transcription]; Region: IclR; COG1414 941967006893 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 941967006894 Bacterial transcriptional regulator; Region: IclR; pfam01614 941967006895 enoyl-CoA hydratase; Provisional; Region: PRK08138 941967006896 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 941967006897 substrate binding site [chemical binding]; other site 941967006898 oxyanion hole (OAH) forming residues; other site 941967006899 trimer interface [polypeptide binding]; other site 941967006900 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 941967006901 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 941967006902 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 941967006903 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 941967006904 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 941967006905 CoA-transferase family III; Region: CoA_transf_3; pfam02515 941967006906 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 941967006907 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 941967006908 putative active site [active] 941967006909 putative FMN binding site [chemical binding]; other site 941967006910 putative substrate binding site [chemical binding]; other site 941967006911 putative catalytic residue [active] 941967006912 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg7; cd04786 941967006913 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 941967006914 DNA binding residues [nucleotide binding] 941967006915 putative dimer interface [polypeptide binding]; other site 941967006916 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 941967006917 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 941967006918 potential catalytic triad [active] 941967006919 conserved cys residue [active] 941967006920 sensor protein QseC; Provisional; Region: PRK10337 941967006921 HAMP domain; Region: HAMP; pfam00672 941967006922 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941967006923 dimer interface [polypeptide binding]; other site 941967006924 phosphorylation site [posttranslational modification] 941967006925 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941967006926 Mg2+ binding site [ion binding]; other site 941967006927 G-X-G motif; other site 941967006928 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941967006929 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941967006930 active site 941967006931 phosphorylation site [posttranslational modification] 941967006932 intermolecular recognition site; other site 941967006933 dimerization interface [polypeptide binding]; other site 941967006934 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941967006935 DNA binding site [nucleotide binding] 941967006936 Uncharacterized conserved protein [Function unknown]; Region: COG5591 941967006937 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 941967006938 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 941967006939 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 941967006940 Flavodoxin; Region: Flavodoxin_1; pfam00258 941967006941 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like2; cd06201 941967006942 FAD binding pocket [chemical binding]; other site 941967006943 FAD binding motif [chemical binding]; other site 941967006944 catalytic residues [active] 941967006945 NAD binding pocket [chemical binding]; other site 941967006946 phosphate binding motif [ion binding]; other site 941967006947 beta-alpha-beta structure motif; other site 941967006948 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 941967006949 ApbE family; Region: ApbE; pfam02424 941967006950 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 941967006951 GAF domain; Region: GAF; pfam01590 941967006952 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941967006953 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941967006954 metal binding site [ion binding]; metal-binding site 941967006955 active site 941967006956 I-site; other site 941967006957 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 941967006958 EamA-like transporter family; Region: EamA; pfam00892 941967006959 EamA-like transporter family; Region: EamA; cl17759 941967006960 Transcriptional regulators [Transcription]; Region: GntR; COG1802 941967006961 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941967006962 DNA-binding site [nucleotide binding]; DNA binding site 941967006963 FCD domain; Region: FCD; pfam07729 941967006964 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 941967006965 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 941967006966 inhibitor site; inhibition site 941967006967 active site 941967006968 dimer interface [polypeptide binding]; other site 941967006969 catalytic residue [active] 941967006970 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 941967006971 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 941967006972 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 941967006973 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 941967006974 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 941967006975 Cytochrome c; Region: Cytochrom_C; pfam00034 941967006976 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 941967006977 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 941967006978 Binuclear center (active site) [active] 941967006979 K-pathway; other site 941967006980 Putative proton exit pathway; other site 941967006981 MoxR-like ATPases [General function prediction only]; Region: COG0714 941967006982 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941967006983 Walker A motif; other site 941967006984 ATP binding site [chemical binding]; other site 941967006985 Walker B motif; other site 941967006986 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 941967006987 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 941967006988 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 941967006989 metal ion-dependent adhesion site (MIDAS); other site 941967006990 Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719 941967006991 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 941967006992 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 941967006993 CPxP motif; other site 941967006994 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 941967006995 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 941967006996 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 941967006997 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 941967006998 nucleophilic elbow; other site 941967006999 catalytic triad; other site 941967007000 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 941967007001 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 941967007002 Multicopper oxidase; Region: Cu-oxidase; pfam00394 941967007003 Uncharacterized conserved protein [Function unknown]; Region: COG1262 941967007004 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 941967007005 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 941967007006 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 941967007007 ligand binding site [chemical binding]; other site 941967007008 flexible hinge region; other site 941967007009 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 941967007010 putative switch regulator; other site 941967007011 non-specific DNA interactions [nucleotide binding]; other site 941967007012 DNA binding site [nucleotide binding] 941967007013 sequence specific DNA binding site [nucleotide binding]; other site 941967007014 putative cAMP binding site [chemical binding]; other site 941967007015 Transcriptional regulators [Transcription]; Region: PurR; COG1609 941967007016 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 941967007017 DNA binding site [nucleotide binding] 941967007018 domain linker motif; other site 941967007019 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 941967007020 dimerization interface [polypeptide binding]; other site 941967007021 ligand binding site [chemical binding]; other site 941967007022 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 941967007023 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 941967007024 putative ligand binding site [chemical binding]; other site 941967007025 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 941967007026 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941967007027 Walker A/P-loop; other site 941967007028 ATP binding site [chemical binding]; other site 941967007029 Q-loop/lid; other site 941967007030 ABC transporter signature motif; other site 941967007031 Walker B; other site 941967007032 D-loop; other site 941967007033 H-loop/switch region; other site 941967007034 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 941967007035 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 941967007036 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 941967007037 TM-ABC transporter signature motif; other site 941967007038 short chain dehydrogenase; Provisional; Region: PRK08219 941967007039 classical (c) SDRs; Region: SDR_c; cd05233 941967007040 NAD(P) binding site [chemical binding]; other site 941967007041 active site 941967007042 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 941967007043 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 941967007044 N- and C-terminal domain interface [polypeptide binding]; other site 941967007045 active site 941967007046 MgATP binding site [chemical binding]; other site 941967007047 catalytic site [active] 941967007048 metal binding site [ion binding]; metal-binding site 941967007049 carbohydrate binding site [chemical binding]; other site 941967007050 putative homodimer interface [polypeptide binding]; other site 941967007051 RES domain; Region: RES; smart00953 941967007052 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 941967007053 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 941967007054 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 941967007055 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 941967007056 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 941967007057 ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163 941967007058 4Fe-4S binding domain; Region: Fer4_5; pfam12801 941967007059 4Fe-4S binding domain; Region: Fer4_5; pfam12801 941967007060 potential frameshift: common BLAST hit: gi|376278253|ref|YP_005108286.1| nitrous-oxide reductase 941967007061 nitrous-oxide reductase; Validated; Region: PRK02888 941967007062 nitrous-oxide reductase; Validated; Region: PRK02888 941967007063 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 941967007064 Nitrous oxidase accessory protein [Inorganic ion transport and metabolism]; Region: NosD; COG3420 941967007065 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 941967007066 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 941967007067 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 941967007068 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 941967007069 Walker A/P-loop; other site 941967007070 ATP binding site [chemical binding]; other site 941967007071 Q-loop/lid; other site 941967007072 ABC transporter signature motif; other site 941967007073 Walker B; other site 941967007074 D-loop; other site 941967007075 H-loop/switch region; other site 941967007076 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 941967007077 Predicted lipoprotein involved in nitrous oxide reduction [Energy production and conversion]; Region: NosL; COG4314 941967007078 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 941967007079 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 941967007080 ApbE family; Region: ApbE; pfam02424 941967007081 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 941967007082 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 941967007083 ligand binding site [chemical binding]; other site 941967007084 flexible hinge region; other site 941967007085 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 941967007086 putative switch regulator; other site 941967007087 non-specific DNA interactions [nucleotide binding]; other site 941967007088 DNA binding site [nucleotide binding] 941967007089 sequence specific DNA binding site [nucleotide binding]; other site 941967007090 putative cAMP binding site [chemical binding]; other site 941967007091 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 941967007092 pseudoazurin; Region: pseudoazurin; TIGR02375 941967007093 Uncharacterized protein involved in response to NO [Inorganic ion transport and metabolism]; Region: NnrS; COG3213 941967007094 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 941967007095 NMT1-like family; Region: NMT1_2; pfam13379 941967007096 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 941967007097 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967007098 dimer interface [polypeptide binding]; other site 941967007099 conserved gate region; other site 941967007100 putative PBP binding loops; other site 941967007101 ABC-ATPase subunit interface; other site 941967007102 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 941967007103 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941967007104 ABC transporter signature motif; other site 941967007105 Walker B; other site 941967007106 D-loop; other site 941967007107 H-loop/switch region; other site 941967007108 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 941967007109 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941967007110 Walker A/P-loop; other site 941967007111 ATP binding site [chemical binding]; other site 941967007112 Q-loop/lid; other site 941967007113 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 941967007114 putative protease; Provisional; Region: PRK15447 941967007115 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 941967007116 Peptidase family U32; Region: Peptidase_U32; pfam01136 941967007117 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 941967007118 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 941967007119 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 941967007120 Flavoprotein; Region: Flavoprotein; pfam02441 941967007121 Protein of unknown function (DUF2478); Region: DUF2478; pfam10649 941967007122 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 941967007123 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 941967007124 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 941967007125 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 941967007126 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 941967007127 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 941967007128 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 941967007129 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 941967007130 [4Fe-4S] binding site [ion binding]; other site 941967007131 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 941967007132 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 941967007133 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 941967007134 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 941967007135 molybdopterin cofactor binding site; other site 941967007136 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 941967007137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941967007138 putative substrate translocation pore; other site 941967007139 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 941967007140 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941967007141 transcriptional activator FtrB; Provisional; Region: ftrB; PRK09392 941967007142 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 941967007143 ligand binding site [chemical binding]; other site 941967007144 flexible hinge region; other site 941967007145 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 941967007146 Transcriptional regulators [Transcription]; Region: PurR; COG1609 941967007147 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 941967007148 DNA binding site [nucleotide binding] 941967007149 domain linker motif; other site 941967007150 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 941967007151 ligand binding site [chemical binding]; other site 941967007152 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 941967007153 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 941967007154 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 941967007155 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967007156 dimer interface [polypeptide binding]; other site 941967007157 conserved gate region; other site 941967007158 putative PBP binding loops; other site 941967007159 ABC-ATPase subunit interface; other site 941967007160 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 941967007161 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967007162 dimer interface [polypeptide binding]; other site 941967007163 conserved gate region; other site 941967007164 putative PBP binding loops; other site 941967007165 ABC-ATPase subunit interface; other site 941967007166 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 941967007167 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 941967007168 Walker A/P-loop; other site 941967007169 ATP binding site [chemical binding]; other site 941967007170 Q-loop/lid; other site 941967007171 ABC transporter signature motif; other site 941967007172 Walker B; other site 941967007173 D-loop; other site 941967007174 H-loop/switch region; other site 941967007175 TOBE domain; Region: TOBE_2; pfam08402 941967007176 Trehalose utilization protein [Carbohydrate transport and metabolism]; Region: ThuA; COG4813 941967007177 conserved cys residue [active] 941967007178 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 941967007179 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 941967007180 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 941967007181 Transmembrane secretion effector; Region: MFS_3; pfam05977 941967007182 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941967007183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941967007184 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 941967007185 catalytic residues [active] 941967007186 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 941967007187 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 941967007188 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 941967007189 Class I ribonucleotide reductase; Region: RNR_I; cd01679 941967007190 active site 941967007191 dimer interface [polypeptide binding]; other site 941967007192 catalytic residues [active] 941967007193 effector binding site; other site 941967007194 R2 peptide binding site; other site 941967007195 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 941967007196 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 941967007197 dimer interface [polypeptide binding]; other site 941967007198 putative radical transfer pathway; other site 941967007199 diiron center [ion binding]; other site 941967007200 tyrosyl radical; other site 941967007201 septum formation inhibitor; Reviewed; Region: minC; PRK05177 941967007202 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 941967007203 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 941967007204 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 941967007205 Switch I; other site 941967007206 Switch II; other site 941967007207 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 941967007208 Domain of unknown function (DUF3597); Region: DUF3597; pfam12200 941967007209 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 941967007210 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 941967007211 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 941967007212 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 941967007213 Walker A/P-loop; other site 941967007214 ATP binding site [chemical binding]; other site 941967007215 Q-loop/lid; other site 941967007216 ABC transporter signature motif; other site 941967007217 Walker B; other site 941967007218 D-loop; other site 941967007219 H-loop/switch region; other site 941967007220 TOBE domain; Region: TOBE_2; pfam08402 941967007221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967007222 dimer interface [polypeptide binding]; other site 941967007223 conserved gate region; other site 941967007224 putative PBP binding loops; other site 941967007225 ABC-ATPase subunit interface; other site 941967007226 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 941967007227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967007228 dimer interface [polypeptide binding]; other site 941967007229 conserved gate region; other site 941967007230 putative PBP binding loops; other site 941967007231 ABC-ATPase subunit interface; other site 941967007232 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 941967007233 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 941967007234 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 941967007235 HlyD family secretion protein; Region: HlyD_3; pfam13437 941967007236 Predicted membrane protein [Function unknown]; Region: COG4803 941967007237 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 941967007238 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 941967007239 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 941967007240 catalytic residue [active] 941967007241 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 941967007242 Glutaminase; Region: Glutaminase; cl00907 941967007243 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 941967007244 Glutaminase; Region: Glutaminase; cl00907 941967007245 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 941967007246 acid-resistance protein; Provisional; Region: PRK10208 941967007247 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 941967007248 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 941967007249 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 941967007250 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941967007251 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 941967007252 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 941967007253 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 941967007254 Substrate binding site; other site 941967007255 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 941967007256 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 941967007257 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 941967007258 active site 941967007259 substrate binding site [chemical binding]; other site 941967007260 metal binding site [ion binding]; metal-binding site 941967007261 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 941967007262 putative active site pocket [active] 941967007263 cleavage site 941967007264 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 941967007265 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 941967007266 putative ion selectivity filter; other site 941967007267 putative pore gating glutamate residue; other site 941967007268 putative H+/Cl- coupling transport residue; other site 941967007269 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 941967007270 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 941967007271 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 941967007272 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 941967007273 active site 941967007274 Cytochrome c [Energy production and conversion]; Region: COG3258 941967007275 Cytochrome c; Region: Cytochrom_C; pfam00034 941967007276 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 941967007277 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941967007278 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 941967007279 dimerization interface [polypeptide binding]; other site 941967007280 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 941967007281 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 941967007282 tetramer interface [polypeptide binding]; other site 941967007283 heme binding pocket [chemical binding]; other site 941967007284 NADPH binding site [chemical binding]; other site 941967007285 Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495 941967007286 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 941967007287 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 941967007288 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 941967007289 CoenzymeA binding site [chemical binding]; other site 941967007290 subunit interaction site [polypeptide binding]; other site 941967007291 PHB binding site; other site 941967007292 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06026 941967007293 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, putative; Region: MTA/SAH-nuc-hyp; TIGR01705 941967007294 GMP synthase; Reviewed; Region: guaA; PRK00074 941967007295 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 941967007296 AMP/PPi binding site [chemical binding]; other site 941967007297 candidate oxyanion hole; other site 941967007298 catalytic triad [active] 941967007299 potential glutamine specificity residues [chemical binding]; other site 941967007300 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 941967007301 ATP Binding subdomain [chemical binding]; other site 941967007302 Ligand Binding sites [chemical binding]; other site 941967007303 Dimerization subdomain; other site 941967007304 Uncharacterized protein probably involved in high-affinity Fe2+ transport [Inorganic ion transport and metabolism]; Region: Tpd; COG3470 941967007305 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 941967007306 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 941967007307 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 941967007308 4Fe-4S binding domain; Region: Fer4_5; pfam12801 941967007309 putative phosphoketolase; Provisional; Region: PRK05261 941967007310 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 941967007311 TPP-binding site; other site 941967007312 XFP C-terminal domain; Region: XFP_C; pfam09363 941967007313 acetate kinase; Provisional; Region: PRK07058 941967007314 propionate/acetate kinase; Provisional; Region: PRK12379 941967007315 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 941967007316 Cytochrome P450; Region: p450; cl12078 941967007317 Transcriptional regulators [Transcription]; Region: GntR; COG1802 941967007318 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941967007319 DNA-binding site [nucleotide binding]; DNA binding site 941967007320 FCD domain; Region: FCD; pfam07729 941967007321 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 941967007322 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 941967007323 NAD(P) binding site [chemical binding]; other site 941967007324 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 941967007325 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 941967007326 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 941967007327 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 941967007328 TM-ABC transporter signature motif; other site 941967007329 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 941967007330 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 941967007331 TM-ABC transporter signature motif; other site 941967007332 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 941967007333 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 941967007334 Walker A/P-loop; other site 941967007335 ATP binding site [chemical binding]; other site 941967007336 Q-loop/lid; other site 941967007337 ABC transporter signature motif; other site 941967007338 Walker B; other site 941967007339 D-loop; other site 941967007340 H-loop/switch region; other site 941967007341 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 941967007342 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 941967007343 Walker A/P-loop; other site 941967007344 ATP binding site [chemical binding]; other site 941967007345 Q-loop/lid; other site 941967007346 ABC transporter signature motif; other site 941967007347 Walker B; other site 941967007348 D-loop; other site 941967007349 H-loop/switch region; other site 941967007350 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 941967007351 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941967007352 NAD(P) binding site [chemical binding]; other site 941967007353 active site 941967007354 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 941967007355 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 941967007356 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 941967007357 shikimate binding site; other site 941967007358 NAD(P) binding site [chemical binding]; other site 941967007359 choline dehydrogenase; Validated; Region: PRK02106 941967007360 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 941967007361 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 941967007362 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 941967007363 tetramerization interface [polypeptide binding]; other site 941967007364 NAD(P) binding site [chemical binding]; other site 941967007365 catalytic residues [active] 941967007366 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 941967007367 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 941967007368 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 941967007369 Zinc-dependent alcohol dehydrogenases (ADH) and class III ADG (AKA formaldehyde dehydrogenase); Region: liver_ADH_like1; cd08281 941967007370 NAD binding site [chemical binding]; other site 941967007371 catalytic Zn binding site [ion binding]; other site 941967007372 substrate binding site [chemical binding]; other site 941967007373 structural Zn binding site [ion binding]; other site 941967007374 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 941967007375 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 941967007376 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 941967007377 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 941967007378 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 941967007379 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 941967007380 Walker A/P-loop; other site 941967007381 ATP binding site [chemical binding]; other site 941967007382 Q-loop/lid; other site 941967007383 ABC transporter signature motif; other site 941967007384 Walker B; other site 941967007385 D-loop; other site 941967007386 H-loop/switch region; other site 941967007387 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 941967007388 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 941967007389 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 941967007390 Walker A/P-loop; other site 941967007391 ATP binding site [chemical binding]; other site 941967007392 Q-loop/lid; other site 941967007393 ABC transporter signature motif; other site 941967007394 Walker B; other site 941967007395 D-loop; other site 941967007396 H-loop/switch region; other site 941967007397 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 941967007398 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 941967007399 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 941967007400 inhibitor site; inhibition site 941967007401 active site 941967007402 dimer interface [polypeptide binding]; other site 941967007403 catalytic residue [active] 941967007404 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 941967007405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967007406 dimer interface [polypeptide binding]; other site 941967007407 conserved gate region; other site 941967007408 putative PBP binding loops; other site 941967007409 ABC-ATPase subunit interface; other site 941967007410 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 941967007411 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967007412 dimer interface [polypeptide binding]; other site 941967007413 conserved gate region; other site 941967007414 putative PBP binding loops; other site 941967007415 ABC-ATPase subunit interface; other site 941967007416 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 941967007417 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 941967007418 Transcriptional regulators [Transcription]; Region: FadR; COG2186 941967007419 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941967007420 DNA-binding site [nucleotide binding]; DNA binding site 941967007421 FCD domain; Region: FCD; pfam07729 941967007422 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 941967007423 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 941967007424 putative active site cavity [active] 941967007425 N-acetylmannosamine kinase; Provisional; Region: PRK05082 941967007426 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 941967007427 nucleotide binding site [chemical binding]; other site 941967007428 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 941967007429 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 941967007430 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 941967007431 ligand binding site [chemical binding]; other site 941967007432 flexible hinge region; other site 941967007433 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 941967007434 putative switch regulator; other site 941967007435 non-specific DNA interactions [nucleotide binding]; other site 941967007436 DNA binding site [nucleotide binding] 941967007437 sequence specific DNA binding site [nucleotide binding]; other site 941967007438 putative cAMP binding site [chemical binding]; other site 941967007439 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 941967007440 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 941967007441 DNA binding residues [nucleotide binding] 941967007442 dimerization interface [polypeptide binding]; other site 941967007443 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 941967007444 Chain length determinant protein; Region: Wzz; cl15801 941967007445 AAA domain; Region: AAA_31; pfam13614 941967007446 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 941967007447 G3 box; other site 941967007448 Switch II region; other site 941967007449 G4 box; other site 941967007450 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 941967007451 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 941967007452 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941967007453 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941967007454 NAD(P) binding site [chemical binding]; other site 941967007455 active site 941967007456 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 941967007457 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 941967007458 NADP-binding site; other site 941967007459 homotetramer interface [polypeptide binding]; other site 941967007460 substrate binding site [chemical binding]; other site 941967007461 homodimer interface [polypeptide binding]; other site 941967007462 active site 941967007463 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 941967007464 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 941967007465 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 941967007466 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 941967007467 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 941967007468 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 941967007469 putative ADP-binding pocket [chemical binding]; other site 941967007470 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 941967007471 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 941967007472 putative trimer interface [polypeptide binding]; other site 941967007473 putative active site [active] 941967007474 putative substrate binding site [chemical binding]; other site 941967007475 putative CoA binding site [chemical binding]; other site 941967007476 Uncharacterized conserved protein [Function unknown]; Region: COG1434 941967007477 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 941967007478 putative active site [active] 941967007479 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 941967007480 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 941967007481 putative metal binding site; other site 941967007482 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 941967007483 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 941967007484 Mg++ binding site [ion binding]; other site 941967007485 putative catalytic motif [active] 941967007486 substrate binding site [chemical binding]; other site 941967007487 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 941967007488 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 941967007489 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 941967007490 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 941967007491 active site 941967007492 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 941967007493 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 941967007494 potential frameshift: common BLAST hit: gi|376276860|ref|YP_005152921.1| glycoside hydrolase family protein 941967007495 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 941967007496 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 941967007497 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 941967007498 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 941967007499 glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209 941967007500 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 941967007501 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 941967007502 catalytic residue [active] 941967007503 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 941967007504 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 941967007505 extended (e) SDRs; Region: SDR_e; cd08946 941967007506 NAD(P) binding site [chemical binding]; other site 941967007507 active site 941967007508 substrate binding site [chemical binding]; other site 941967007509 Uncharacterized protein conserved in bacteria with an aminopeptidase-like domain [General function prediction only]; Region: COG4310 941967007510 M28 Zn-Peptidases; Region: M28_like_3; cd05644 941967007511 active site 941967007512 metal binding site [ion binding]; metal-binding site 941967007513 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 941967007514 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 941967007515 Methyltransferase domain; Region: Methyltransf_23; pfam13489 941967007516 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941967007517 S-adenosylmethionine binding site [chemical binding]; other site 941967007518 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 941967007519 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 941967007520 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 941967007521 active site 941967007522 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 941967007523 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 941967007524 potential frameshift: common BLAST hit: gi|340792174|ref|YP_004757638.1| glycerol kinase 941967007525 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 941967007526 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 941967007527 nucleotide binding site [chemical binding]; other site 941967007528 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 941967007529 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 941967007530 nucleotide binding site [chemical binding]; other site 941967007531 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 941967007532 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941967007533 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941967007534 putative substrate translocation pore; other site 941967007535 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 941967007536 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941967007537 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 941967007538 putative dimerization interface [polypeptide binding]; other site 941967007539 putative substrate binding pocket [chemical binding]; other site 941967007540 methionine sulfoxide reductase B; Provisional; Region: PRK00222 941967007541 SelR domain; Region: SelR; pfam01641 941967007542 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 941967007543 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 941967007544 active site 941967007545 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 941967007546 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 941967007547 dimer interface [polypeptide binding]; other site 941967007548 active site 941967007549 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 941967007550 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 941967007551 NAD binding site [chemical binding]; other site 941967007552 homodimer interface [polypeptide binding]; other site 941967007553 homotetramer interface [polypeptide binding]; other site 941967007554 active site 941967007555 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 941967007556 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 941967007557 active site 941967007558 CoA binding site [chemical binding]; other site 941967007559 AMP binding site [chemical binding]; other site 941967007560 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 941967007561 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 941967007562 acyl-activating enzyme (AAE) consensus motif; other site 941967007563 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 941967007564 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 941967007565 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941967007566 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 941967007567 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 941967007568 ligand binding site [chemical binding]; other site 941967007569 NAD binding site [chemical binding]; other site 941967007570 tetramer interface [polypeptide binding]; other site 941967007571 catalytic site [active] 941967007572 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 941967007573 L-serine binding site [chemical binding]; other site 941967007574 ACT domain interface; other site 941967007575 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 941967007576 active site 941967007577 catalytic residues [active] 941967007578 metal binding site [ion binding]; metal-binding site 941967007579 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 941967007580 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 941967007581 dimerization interface [polypeptide binding]; other site 941967007582 putative DNA binding site [nucleotide binding]; other site 941967007583 putative Zn2+ binding site [ion binding]; other site 941967007584 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 941967007585 Predicted transporter component [General function prediction only]; Region: COG2391 941967007586 Predicted transporter component [General function prediction only]; Region: COG2391 941967007587 Sulphur transport; Region: Sulf_transp; pfam04143 941967007588 Transcriptional regulators [Transcription]; Region: GntR; COG1802 941967007589 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941967007590 DNA-binding site [nucleotide binding]; DNA binding site 941967007591 FCD domain; Region: FCD; pfam07729 941967007592 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 941967007593 Domain of unknown function DUF20; Region: UPF0118; pfam01594 941967007594 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 941967007595 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941967007596 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 941967007597 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 941967007598 Peptidase family M23; Region: Peptidase_M23; pfam01551 941967007599 HlyD family secretion protein; Region: HlyD_3; pfam13437 941967007600 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 941967007601 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 941967007602 Walker A/P-loop; other site 941967007603 ATP binding site [chemical binding]; other site 941967007604 Q-loop/lid; other site 941967007605 ABC transporter signature motif; other site 941967007606 Walker B; other site 941967007607 D-loop; other site 941967007608 H-loop/switch region; other site 941967007609 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 941967007610 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 941967007611 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 941967007612 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 941967007613 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 941967007614 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967007615 dimer interface [polypeptide binding]; other site 941967007616 conserved gate region; other site 941967007617 putative PBP binding loops; other site 941967007618 ABC-ATPase subunit interface; other site 941967007619 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 941967007620 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 941967007621 Walker A/P-loop; other site 941967007622 ATP binding site [chemical binding]; other site 941967007623 Q-loop/lid; other site 941967007624 ABC transporter signature motif; other site 941967007625 Walker B; other site 941967007626 D-loop; other site 941967007627 H-loop/switch region; other site 941967007628 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 941967007629 NMT1/THI5 like; Region: NMT1; pfam09084 941967007630 substrate binding pocket [chemical binding]; other site 941967007631 membrane-bound complex binding site; other site 941967007632 hinge residues; other site 941967007633 MarR family; Region: MarR_2; pfam12802 941967007634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941967007635 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941967007636 putative substrate translocation pore; other site 941967007637 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 941967007638 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 941967007639 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 941967007640 HlyD family secretion protein; Region: HlyD_3; pfam13437 941967007641 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941967007642 HAMP domain; Region: HAMP; pfam00672 941967007643 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941967007644 dimer interface [polypeptide binding]; other site 941967007645 phosphorylation site [posttranslational modification] 941967007646 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941967007647 ATP binding site [chemical binding]; other site 941967007648 Mg2+ binding site [ion binding]; other site 941967007649 G-X-G motif; other site 941967007650 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941967007651 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941967007652 active site 941967007653 phosphorylation site [posttranslational modification] 941967007654 intermolecular recognition site; other site 941967007655 dimerization interface [polypeptide binding]; other site 941967007656 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941967007657 DNA binding site [nucleotide binding] 941967007658 Uncharacterized conserved protein [Function unknown]; Region: COG3189 941967007659 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 941967007660 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 941967007661 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 941967007662 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 941967007663 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 941967007664 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 941967007665 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 941967007666 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 941967007667 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 941967007668 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 941967007669 potential frameshift: common BLAST hit: gi|376276807|ref|YP_005152868.1| glycosyl hydrolase family protein 941967007670 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 941967007671 active site 941967007672 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 941967007673 Homoserine trans-succinylase [Amino acid transport and metabolism]; Region: MetA; COG1897 941967007674 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 941967007675 proposed active site lysine [active] 941967007676 conserved cys residue [active] 941967007677 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05963 941967007678 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 941967007679 dimer interface [polypeptide binding]; other site 941967007680 active site 941967007681 CoA binding pocket [chemical binding]; other site 941967007682 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 941967007683 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 941967007684 inhibitor-cofactor binding pocket; inhibition site 941967007685 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941967007686 catalytic residue [active] 941967007687 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 941967007688 AAA domain; Region: AAA_26; pfam13500 941967007689 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 941967007690 hypothetical protein; Provisional; Region: PRK07505 941967007691 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 941967007692 catalytic residue [active] 941967007693 biotin synthase; Region: bioB; TIGR00433 941967007694 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941967007695 FeS/SAM binding site; other site 941967007696 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 941967007697 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 941967007698 MPT binding site; other site 941967007699 trimer interface [polypeptide binding]; other site 941967007700 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 941967007701 dimer interface [polypeptide binding]; other site 941967007702 FMN binding site [chemical binding]; other site 941967007703 potential frameshift: common BLAST hit: gi|376271280|ref|YP_005114325.1| hydroxyacylglutathione hydrolase 941967007704 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 941967007705 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 941967007706 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 941967007707 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 941967007708 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 941967007709 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 941967007710 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 941967007711 monovalent cation:proton antiporter; Region: 2a6301s02; TIGR00943 941967007712 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 941967007713 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 941967007714 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 941967007715 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12596 941967007716 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 941967007717 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12671 941967007718 Predicted transcriptional regulators [Transcription]; Region: COG1510 941967007719 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 941967007720 dimerization interface [polypeptide binding]; other site 941967007721 putative DNA binding site [nucleotide binding]; other site 941967007722 putative Zn2+ binding site [ion binding]; other site 941967007723 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 941967007724 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 941967007725 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 941967007726 Walker A/P-loop; other site 941967007727 ATP binding site [chemical binding]; other site 941967007728 Q-loop/lid; other site 941967007729 ABC transporter signature motif; other site 941967007730 Walker B; other site 941967007731 D-loop; other site 941967007732 H-loop/switch region; other site 941967007733 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 941967007734 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941967007735 Walker A/P-loop; other site 941967007736 ATP binding site [chemical binding]; other site 941967007737 Q-loop/lid; other site 941967007738 ABC transporter signature motif; other site 941967007739 Walker B; other site 941967007740 D-loop; other site 941967007741 H-loop/switch region; other site 941967007742 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 941967007743 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 941967007744 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 941967007745 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 941967007746 Predicted outer membrane lipoprotein [Function unknown]; Region: COG4890 941967007747 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 941967007748 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941967007749 DNA-binding site [nucleotide binding]; DNA binding site 941967007750 UTRA domain; Region: UTRA; pfam07702 941967007751 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 941967007752 nucleotide binding site [chemical binding]; other site 941967007753 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 941967007754 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 941967007755 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 941967007756 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 941967007757 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 941967007758 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967007759 dimer interface [polypeptide binding]; other site 941967007760 conserved gate region; other site 941967007761 putative PBP binding loops; other site 941967007762 ABC-ATPase subunit interface; other site 941967007763 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 941967007764 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967007765 dimer interface [polypeptide binding]; other site 941967007766 conserved gate region; other site 941967007767 putative PBP binding loops; other site 941967007768 ABC-ATPase subunit interface; other site 941967007769 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 941967007770 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 941967007771 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 941967007772 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 941967007773 Walker A/P-loop; other site 941967007774 ATP binding site [chemical binding]; other site 941967007775 Q-loop/lid; other site 941967007776 ABC transporter signature motif; other site 941967007777 Walker B; other site 941967007778 D-loop; other site 941967007779 H-loop/switch region; other site 941967007780 TOBE domain; Region: TOBE_2; pfam08402 941967007781 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573 941967007782 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 941967007783 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 941967007784 tetramer interface [polypeptide binding]; other site 941967007785 TPP-binding site [chemical binding]; other site 941967007786 heterodimer interface [polypeptide binding]; other site 941967007787 phosphorylation loop region [posttranslational modification] 941967007788 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 941967007789 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 941967007790 alpha subunit interface [polypeptide binding]; other site 941967007791 TPP binding site [chemical binding]; other site 941967007792 heterodimer interface [polypeptide binding]; other site 941967007793 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 941967007794 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 941967007795 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 941967007796 E3 interaction surface; other site 941967007797 lipoyl attachment site [posttranslational modification]; other site 941967007798 e3 binding domain; Region: E3_binding; pfam02817 941967007799 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 941967007800 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 941967007801 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 941967007802 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 941967007803 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 941967007804 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 941967007805 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 941967007806 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 941967007807 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 941967007808 homodimer interface [polypeptide binding]; other site 941967007809 homotetramer interface [polypeptide binding]; other site 941967007810 active site pocket [active] 941967007811 cleavage site 941967007812 benzoate transport; Region: 2A0115; TIGR00895 941967007813 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941967007814 putative substrate translocation pore; other site 941967007815 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 941967007816 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 941967007817 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 941967007818 Walker A/P-loop; other site 941967007819 ATP binding site [chemical binding]; other site 941967007820 Q-loop/lid; other site 941967007821 ABC transporter signature motif; other site 941967007822 Walker B; other site 941967007823 D-loop; other site 941967007824 H-loop/switch region; other site 941967007825 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 941967007826 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 941967007827 Walker A/P-loop; other site 941967007828 ATP binding site [chemical binding]; other site 941967007829 Q-loop/lid; other site 941967007830 ABC transporter signature motif; other site 941967007831 Walker B; other site 941967007832 D-loop; other site 941967007833 H-loop/switch region; other site 941967007834 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 941967007835 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 941967007836 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967007837 dimer interface [polypeptide binding]; other site 941967007838 conserved gate region; other site 941967007839 ABC-ATPase subunit interface; other site 941967007840 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 941967007841 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967007842 dimer interface [polypeptide binding]; other site 941967007843 conserved gate region; other site 941967007844 putative PBP binding loops; other site 941967007845 ABC-ATPase subunit interface; other site 941967007846 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 941967007847 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 941967007848 peptide binding site [polypeptide binding]; other site 941967007849 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 941967007850 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 941967007851 peptide binding site [polypeptide binding]; other site 941967007852 Predicted integral membrane protein [Function unknown]; Region: COG5455 941967007853 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941967007854 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 941967007855 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 941967007856 NAD binding site [chemical binding]; other site 941967007857 homodimer interface [polypeptide binding]; other site 941967007858 active site 941967007859 substrate binding site [chemical binding]; other site 941967007860 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 941967007861 active site 941967007862 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 941967007863 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 941967007864 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 941967007865 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 941967007866 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 941967007867 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 941967007868 Protein of unknown function (DUF995); Region: DUF995; pfam06191 941967007869 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 941967007870 Protein of unknown function (DUF995); Region: DUF995; pfam06191 941967007871 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 941967007872 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941967007873 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 941967007874 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 941967007875 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 941967007876 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 941967007877 yecA family protein; Region: ygfB_yecA; TIGR02292 941967007878 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 941967007879 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 941967007880 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 941967007881 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 941967007882 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 941967007883 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 941967007884 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 941967007885 putative deacylase active site [active] 941967007886 iron-responsive transcriptional regulator; Reviewed; Region: rirA; PRK11920 941967007887 Predicted transcriptional regulator [Transcription]; Region: COG1959 941967007888 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 941967007889 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 941967007890 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 941967007891 heme binding site [chemical binding]; other site 941967007892 ferroxidase pore; other site 941967007893 ferroxidase diiron center [ion binding]; other site 941967007894 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 941967007895 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 941967007896 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941967007897 FeS/SAM binding site; other site 941967007898 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 941967007899 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 941967007900 putative ligand binding site [chemical binding]; other site 941967007901 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 941967007902 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 941967007903 TM-ABC transporter signature motif; other site 941967007904 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 941967007905 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 941967007906 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 941967007907 TM-ABC transporter signature motif; other site 941967007908 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 941967007909 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 941967007910 Walker A/P-loop; other site 941967007911 ATP binding site [chemical binding]; other site 941967007912 Q-loop/lid; other site 941967007913 ABC transporter signature motif; other site 941967007914 Walker B; other site 941967007915 D-loop; other site 941967007916 H-loop/switch region; other site 941967007917 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 941967007918 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 941967007919 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 941967007920 NADP binding site [chemical binding]; other site 941967007921 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 941967007922 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 941967007923 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494 941967007924 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 941967007925 Uncharacterized conserved protein [Function unknown]; Region: COG3785 941967007926 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 941967007927 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 941967007928 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 941967007929 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 941967007930 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 941967007931 catalytic residues [active] 941967007932 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 941967007933 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 941967007934 active site 941967007935 metal binding site [ion binding]; metal-binding site 941967007936 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 941967007937 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 941967007938 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 941967007939 ATP binding site [chemical binding]; other site 941967007940 putative Mg++ binding site [ion binding]; other site 941967007941 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941967007942 nucleotide binding region [chemical binding]; other site 941967007943 ATP-binding site [chemical binding]; other site 941967007944 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 941967007945 Uncharacterized conserved protein [Function unknown]; Region: COG2938 941967007946 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 941967007947 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 941967007948 generic binding surface II; other site 941967007949 ssDNA binding site; other site 941967007950 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 941967007951 ATP binding site [chemical binding]; other site 941967007952 putative Mg++ binding site [ion binding]; other site 941967007953 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941967007954 nucleotide binding region [chemical binding]; other site 941967007955 ATP-binding site [chemical binding]; other site 941967007956 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 941967007957 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 941967007958 glutaminase active site [active] 941967007959 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 941967007960 dimer interface [polypeptide binding]; other site 941967007961 active site 941967007962 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 941967007963 dimer interface [polypeptide binding]; other site 941967007964 active site 941967007965 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 941967007966 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 941967007967 Substrate binding site; other site 941967007968 Mg++ binding site; other site 941967007969 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 941967007970 active site 941967007971 substrate binding site [chemical binding]; other site 941967007972 CoA binding site [chemical binding]; other site 941967007973 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 941967007974 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 941967007975 Predicted integral membrane protein [Function unknown]; Region: COG0392 941967007976 Uncharacterized conserved protein [Function unknown]; Region: COG2898 941967007977 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 941967007978 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 941967007979 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 941967007980 BA14K-like protein; Region: BA14K; pfam07886 941967007981 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941967007982 PAS domain; Region: PAS_9; pfam13426 941967007983 putative active site [active] 941967007984 heme pocket [chemical binding]; other site 941967007985 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941967007986 PAS fold; Region: PAS_3; pfam08447 941967007987 putative active site [active] 941967007988 heme pocket [chemical binding]; other site 941967007989 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 941967007990 HWE histidine kinase; Region: HWE_HK; pfam07536 941967007991 lipoate-protein ligase B; Provisional; Region: PRK14341 941967007992 EamA-like transporter family; Region: EamA; pfam00892 941967007993 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 941967007994 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 941967007995 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941967007996 Mg2+ binding site [ion binding]; other site 941967007997 G-X-G motif; other site 941967007998 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 941967007999 anchoring element; other site 941967008000 dimer interface [polypeptide binding]; other site 941967008001 ATP binding site [chemical binding]; other site 941967008002 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 941967008003 active site 941967008004 metal binding site [ion binding]; metal-binding site 941967008005 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 941967008006 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 941967008007 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 941967008008 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 941967008009 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 941967008010 metal-dependent hydrolase; Provisional; Region: PRK00685 941967008011 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 941967008012 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 941967008013 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 941967008014 active site 941967008015 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 941967008016 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 941967008017 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 941967008018 dihydroorotase; Validated; Region: PRK09059 941967008019 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 941967008020 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 941967008021 active site 941967008022 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 941967008023 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 941967008024 DNA protecting protein DprA; Region: dprA; TIGR00732 941967008025 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 941967008026 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 941967008027 active site 941967008028 interdomain interaction site; other site 941967008029 putative metal-binding site [ion binding]; other site 941967008030 nucleotide binding site [chemical binding]; other site 941967008031 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 941967008032 domain I; other site 941967008033 DNA binding groove [nucleotide binding] 941967008034 phosphate binding site [ion binding]; other site 941967008035 domain II; other site 941967008036 domain III; other site 941967008037 nucleotide binding site [chemical binding]; other site 941967008038 catalytic site [active] 941967008039 domain IV; other site 941967008040 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 941967008041 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 941967008042 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 941967008043 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 941967008044 ribonuclease R; Region: RNase_R; TIGR02063 941967008045 RNB domain; Region: RNB; pfam00773 941967008046 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 941967008047 RNA binding site [nucleotide binding]; other site 941967008048 hypothetical protein; Provisional; Region: PRK05978 941967008049 NUDIX domain; Region: NUDIX; pfam00293 941967008050 nudix motif; other site 941967008051 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941967008052 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941967008053 putative substrate translocation pore; other site 941967008054 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 941967008055 response regulator PleD; Reviewed; Region: pleD; PRK09581 941967008056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941967008057 active site 941967008058 phosphorylation site [posttranslational modification] 941967008059 intermolecular recognition site; other site 941967008060 dimerization interface [polypeptide binding]; other site 941967008061 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941967008062 active site 941967008063 phosphorylation site [posttranslational modification] 941967008064 intermolecular recognition site; other site 941967008065 dimerization interface [polypeptide binding]; other site 941967008066 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941967008067 metal binding site [ion binding]; metal-binding site 941967008068 active site 941967008069 I-site; other site 941967008070 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 941967008071 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941967008072 active site 941967008073 phosphorylation site [posttranslational modification] 941967008074 intermolecular recognition site; other site 941967008075 dimerization interface [polypeptide binding]; other site 941967008076 Protein of unknown function (DUF3572); Region: DUF3572; pfam12096 941967008077 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 941967008078 DNA polymerase IV; Provisional; Region: PRK02794 941967008079 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 941967008080 active site 941967008081 DNA binding site [nucleotide binding] 941967008082 Uncharacterized conserved protein [Function unknown]; Region: COG3391 941967008083 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 941967008084 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941967008085 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941967008086 metal binding site [ion binding]; metal-binding site 941967008087 active site 941967008088 I-site; other site 941967008089 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 941967008090 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 941967008091 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 941967008092 active site 941967008093 catalytic site [active] 941967008094 substrate binding site [chemical binding]; other site 941967008095 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941967008096 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 941967008097 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941967008098 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 941967008099 hydroxyglutarate oxidase; Provisional; Region: PRK11728 941967008100 hydroxyglutarate oxidase; Provisional; Region: PRK11728 941967008101 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 941967008102 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941967008103 membrane-bound complex binding site; other site 941967008104 hinge residues; other site 941967008105 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941967008106 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 941967008107 substrate binding pocket [chemical binding]; other site 941967008108 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 941967008109 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941967008110 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 941967008111 putative DNA binding site [nucleotide binding]; other site 941967008112 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 941967008113 putative Zn2+ binding site [ion binding]; other site 941967008114 AsnC family; Region: AsnC_trans_reg; pfam01037 941967008115 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 941967008116 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 941967008117 active site 941967008118 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 941967008119 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 941967008120 dimer interface [polypeptide binding]; other site 941967008121 active site 941967008122 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 941967008123 Coenzyme A transferase; Region: CoA_trans; cl17247 941967008124 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 941967008125 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 941967008126 Bacterial transcriptional regulator; Region: IclR; pfam01614 941967008127 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 941967008128 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941967008129 Cupin domain; Region: Cupin_2; cl17218 941967008130 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 941967008131 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 941967008132 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 941967008133 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941967008134 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 941967008135 dimerization interface [polypeptide binding]; other site 941967008136 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 941967008137 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 941967008138 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 941967008139 active site 941967008140 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 941967008141 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 941967008142 heterodimer interface [polypeptide binding]; other site 941967008143 active site 941967008144 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK05975 941967008145 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 941967008146 tetramer interface [polypeptide binding]; other site 941967008147 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 941967008148 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 941967008149 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 941967008150 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 941967008151 TM-ABC transporter signature motif; other site 941967008152 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 941967008153 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 941967008154 TM-ABC transporter signature motif; other site 941967008155 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 941967008156 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 941967008157 Walker A/P-loop; other site 941967008158 ATP binding site [chemical binding]; other site 941967008159 Q-loop/lid; other site 941967008160 ABC transporter signature motif; other site 941967008161 Walker B; other site 941967008162 D-loop; other site 941967008163 H-loop/switch region; other site 941967008164 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 941967008165 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 941967008166 Walker A/P-loop; other site 941967008167 ATP binding site [chemical binding]; other site 941967008168 Q-loop/lid; other site 941967008169 ABC transporter signature motif; other site 941967008170 Walker B; other site 941967008171 D-loop; other site 941967008172 H-loop/switch region; other site 941967008173 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 941967008174 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 941967008175 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 941967008176 active site 941967008177 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 941967008178 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 941967008179 active site 941967008180 dimer interface [polypeptide binding]; other site 941967008181 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 941967008182 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 941967008183 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 941967008184 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 941967008185 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 941967008186 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967008187 dimer interface [polypeptide binding]; other site 941967008188 conserved gate region; other site 941967008189 ABC-ATPase subunit interface; other site 941967008190 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 941967008191 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 941967008192 Walker A/P-loop; other site 941967008193 ATP binding site [chemical binding]; other site 941967008194 Q-loop/lid; other site 941967008195 ABC transporter signature motif; other site 941967008196 Walker B; other site 941967008197 D-loop; other site 941967008198 H-loop/switch region; other site 941967008199 TOBE domain; Region: TOBE_2; pfam08402 941967008200 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 941967008201 transmembrane helices; other site 941967008202 TrkA-C domain; Region: TrkA_C; pfam02080 941967008203 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 941967008204 TrkA-C domain; Region: TrkA_C; pfam02080 941967008205 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 941967008206 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 941967008207 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 941967008208 nucleoside/Zn binding site; other site 941967008209 dimer interface [polypeptide binding]; other site 941967008210 catalytic motif [active] 941967008211 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 941967008212 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 941967008213 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 941967008214 EamA-like transporter family; Region: EamA; pfam00892 941967008215 aminotransferase; Provisional; Region: PRK13356 941967008216 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 941967008217 homodimer interface [polypeptide binding]; other site 941967008218 substrate-cofactor binding pocket; other site 941967008219 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941967008220 catalytic residue [active] 941967008221 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 941967008222 potential frameshift: common BLAST hit: gi|376271119|ref|YP_005114164.1| FAD-binding dehydrogenase 941967008223 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 941967008224 FAD binding domain; Region: FAD_binding_2; pfam00890 941967008225 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 941967008226 Protein of unknown function (DUF3775); Region: DUF3775; pfam12616 941967008227 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 941967008228 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 941967008229 NAD binding site [chemical binding]; other site 941967008230 catalytic residues [active] 941967008231 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 941967008232 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 941967008233 putative ligand binding residues [chemical binding]; other site 941967008234 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 941967008235 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 941967008236 ABC-ATPase subunit interface; other site 941967008237 dimer interface [polypeptide binding]; other site 941967008238 putative PBP binding regions; other site 941967008239 ABC-type enterochelin transport system, permease component [Inorganic ion transport and metabolism]; Region: CeuC; COG4605 941967008240 ABC-ATPase subunit interface; other site 941967008241 dimer interface [polypeptide binding]; other site 941967008242 putative PBP binding regions; other site 941967008243 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 941967008244 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 941967008245 Walker A/P-loop; other site 941967008246 ATP binding site [chemical binding]; other site 941967008247 Q-loop/lid; other site 941967008248 ABC transporter signature motif; other site 941967008249 Walker B; other site 941967008250 D-loop; other site 941967008251 H-loop/switch region; other site 941967008252 Predicted transcription regulator, contains HTH domain (MarR family) [Transcription]; Region: COG5631 941967008253 5-oxoprolinase; Region: PLN02666 941967008254 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 941967008255 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 941967008256 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 941967008257 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 941967008258 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941967008259 substrate binding pocket [chemical binding]; other site 941967008260 membrane-bound complex binding site; other site 941967008261 hinge residues; other site 941967008262 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967008263 dimer interface [polypeptide binding]; other site 941967008264 conserved gate region; other site 941967008265 putative PBP binding loops; other site 941967008266 ABC-ATPase subunit interface; other site 941967008267 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 941967008268 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941967008269 Walker A/P-loop; other site 941967008270 ATP binding site [chemical binding]; other site 941967008271 Q-loop/lid; other site 941967008272 ABC transporter signature motif; other site 941967008273 Walker B; other site 941967008274 D-loop; other site 941967008275 H-loop/switch region; other site 941967008276 exopolyphosphatase; Region: exo_poly_only; TIGR03706 941967008277 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 941967008278 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 941967008279 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941967008280 S-adenosylmethionine binding site [chemical binding]; other site 941967008281 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941967008282 putative transporter; Provisional; Region: PRK10504 941967008283 putative substrate translocation pore; other site 941967008284 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941967008285 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 941967008286 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 941967008287 Walker A/P-loop; other site 941967008288 ATP binding site [chemical binding]; other site 941967008289 Q-loop/lid; other site 941967008290 ABC transporter signature motif; other site 941967008291 Walker B; other site 941967008292 D-loop; other site 941967008293 H-loop/switch region; other site 941967008294 TOBE domain; Region: TOBE_2; pfam08402 941967008295 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 941967008296 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967008297 dimer interface [polypeptide binding]; other site 941967008298 conserved gate region; other site 941967008299 putative PBP binding loops; other site 941967008300 ABC-ATPase subunit interface; other site 941967008301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967008302 dimer interface [polypeptide binding]; other site 941967008303 conserved gate region; other site 941967008304 putative PBP binding loops; other site 941967008305 ABC-ATPase subunit interface; other site 941967008306 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 941967008307 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 941967008308 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-II; Region: Lumazine_synthase-II; cd09208 941967008309 active site 941967008310 homopentamer interface [polypeptide binding]; other site 941967008311 dimer interface [polypeptide binding]; other site 941967008312 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 941967008313 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3453 941967008314 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 941967008315 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967008316 dimer interface [polypeptide binding]; other site 941967008317 conserved gate region; other site 941967008318 putative PBP binding loops; other site 941967008319 ABC-ATPase subunit interface; other site 941967008320 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967008321 dimer interface [polypeptide binding]; other site 941967008322 conserved gate region; other site 941967008323 putative PBP binding loops; other site 941967008324 ABC-ATPase subunit interface; other site 941967008325 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 941967008326 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 941967008327 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 941967008328 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 941967008329 Walker A/P-loop; other site 941967008330 ATP binding site [chemical binding]; other site 941967008331 Q-loop/lid; other site 941967008332 ABC transporter signature motif; other site 941967008333 Walker B; other site 941967008334 D-loop; other site 941967008335 H-loop/switch region; other site 941967008336 FAD dependent oxidoreductase; Region: DAO; pfam01266 941967008337 hydroxyglutarate oxidase; Provisional; Region: PRK11728 941967008338 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 941967008339 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 941967008340 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 941967008341 E-class dimer interface [polypeptide binding]; other site 941967008342 P-class dimer interface [polypeptide binding]; other site 941967008343 active site 941967008344 Cu2+ binding site [ion binding]; other site 941967008345 Zn2+ binding site [ion binding]; other site 941967008346 multicopper oxidase; Provisional; Region: PRK10965 941967008347 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 941967008348 Multicopper oxidase; Region: Cu-oxidase; pfam00394 941967008349 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 941967008350 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941967008351 metabolite-proton symporter; Region: 2A0106; TIGR00883 941967008352 putative substrate translocation pore; other site 941967008353 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 941967008354 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 941967008355 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 941967008356 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 941967008357 dimer interface [polypeptide binding]; other site 941967008358 decamer (pentamer of dimers) interface [polypeptide binding]; other site 941967008359 catalytic triad [active] 941967008360 peroxidatic and resolving cysteines [active] 941967008361 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 941967008362 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941967008363 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 941967008364 dimerization interface [polypeptide binding]; other site 941967008365 Protein of unknown function (DUF1612); Region: DUF1612; pfam07756 941967008366 HTH DNA binding domain; Region: HTH_13; pfam11972 941967008367 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 941967008368 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 941967008369 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 941967008370 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 941967008371 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 941967008372 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 941967008373 putative active site [active] 941967008374 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 941967008375 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 941967008376 substrate binding site [chemical binding]; other site 941967008377 ATP binding site [chemical binding]; other site 941967008378 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 941967008379 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 941967008380 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 941967008381 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 941967008382 PYR/PP interface [polypeptide binding]; other site 941967008383 dimer interface [polypeptide binding]; other site 941967008384 TPP binding site [chemical binding]; other site 941967008385 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 941967008386 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 941967008387 TPP-binding site [chemical binding]; other site 941967008388 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 941967008389 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 941967008390 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 941967008391 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 941967008392 active site 941967008393 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 941967008394 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941967008395 Walker A/P-loop; other site 941967008396 ATP binding site [chemical binding]; other site 941967008397 Q-loop/lid; other site 941967008398 ABC transporter signature motif; other site 941967008399 Walker B; other site 941967008400 D-loop; other site 941967008401 H-loop/switch region; other site 941967008402 TOBE domain; Region: TOBE_2; pfam08402 941967008403 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 941967008404 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967008405 dimer interface [polypeptide binding]; other site 941967008406 conserved gate region; other site 941967008407 putative PBP binding loops; other site 941967008408 ABC-ATPase subunit interface; other site 941967008409 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967008410 dimer interface [polypeptide binding]; other site 941967008411 conserved gate region; other site 941967008412 putative PBP binding loops; other site 941967008413 ABC-ATPase subunit interface; other site 941967008414 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 941967008415 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 941967008416 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 941967008417 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 941967008418 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 941967008419 Glutamate binding site [chemical binding]; other site 941967008420 NAD binding site [chemical binding]; other site 941967008421 catalytic residues [active] 941967008422 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 941967008423 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 941967008424 putative DNA binding site [nucleotide binding]; other site 941967008425 putative Zn2+ binding site [ion binding]; other site 941967008426 AsnC family; Region: AsnC_trans_reg; pfam01037 941967008427 glycine dehydrogenase; Provisional; Region: PRK05367 941967008428 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 941967008429 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 941967008430 catalytic residue [active] 941967008431 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 941967008432 tetramer interface [polypeptide binding]; other site 941967008433 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941967008434 catalytic residue [active] 941967008435 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 941967008436 lipoyl attachment site [posttranslational modification]; other site 941967008437 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 941967008438 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 941967008439 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 941967008440 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 941967008441 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 941967008442 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 941967008443 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 941967008444 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 941967008445 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 941967008446 putative active site [active] 941967008447 Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931 941967008448 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 941967008449 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 941967008450 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 941967008451 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 941967008452 putative active site [active] 941967008453 metal binding site [ion binding]; metal-binding site 941967008454 BA14K-like protein; Region: BA14K; pfam07886 941967008455 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 941967008456 EamA-like transporter family; Region: EamA; pfam00892 941967008457 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 941967008458 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 941967008459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967008460 dimer interface [polypeptide binding]; other site 941967008461 conserved gate region; other site 941967008462 putative PBP binding loops; other site 941967008463 ABC-ATPase subunit interface; other site 941967008464 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 941967008465 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 941967008466 Walker A/P-loop; other site 941967008467 ATP binding site [chemical binding]; other site 941967008468 Q-loop/lid; other site 941967008469 ABC transporter signature motif; other site 941967008470 Walker B; other site 941967008471 D-loop; other site 941967008472 H-loop/switch region; other site 941967008473 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 941967008474 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 941967008475 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 941967008476 dimer interface [polypeptide binding]; other site 941967008477 active site 941967008478 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 941967008479 substrate binding site [chemical binding]; other site 941967008480 catalytic residue [active] 941967008481 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 941967008482 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 941967008483 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 941967008484 putative active site [active] 941967008485 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 941967008486 Walker A/P-loop; other site 941967008487 ATP binding site [chemical binding]; other site 941967008488 ABC transporter; Region: ABC_tran; pfam00005 941967008489 Q-loop/lid; other site 941967008490 ABC transporter signature motif; other site 941967008491 Walker B; other site 941967008492 D-loop; other site 941967008493 H-loop/switch region; other site 941967008494 TOBE domain; Region: TOBE; pfam03459 941967008495 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 941967008496 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941967008497 NAD(P) binding site [chemical binding]; other site 941967008498 active site 941967008499 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 941967008500 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 941967008501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967008502 dimer interface [polypeptide binding]; other site 941967008503 conserved gate region; other site 941967008504 putative PBP binding loops; other site 941967008505 ABC-ATPase subunit interface; other site 941967008506 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 941967008507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967008508 dimer interface [polypeptide binding]; other site 941967008509 conserved gate region; other site 941967008510 putative PBP binding loops; other site 941967008511 ABC-ATPase subunit interface; other site 941967008512 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 941967008513 homotrimer interaction site [polypeptide binding]; other site 941967008514 putative active site [active] 941967008515 Uncharacterized conserved protein [Function unknown]; Region: COG5476 941967008516 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 941967008517 MlrC C-terminus; Region: MlrC_C; pfam07171 941967008518 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 941967008519 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 941967008520 Walker A/P-loop; other site 941967008521 ATP binding site [chemical binding]; other site 941967008522 Q-loop/lid; other site 941967008523 ABC transporter signature motif; other site 941967008524 Walker B; other site 941967008525 D-loop; other site 941967008526 H-loop/switch region; other site 941967008527 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 941967008528 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 941967008529 ABC-ATPase subunit interface; other site 941967008530 dimer interface [polypeptide binding]; other site 941967008531 putative PBP binding regions; other site 941967008532 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 941967008533 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 941967008534 putative ligand binding residues [chemical binding]; other site 941967008535 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 941967008536 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 941967008537 HlyD family secretion protein; Region: HlyD_3; pfam13437 941967008538 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 941967008539 Fusaric acid resistance protein family; Region: FUSC; pfam04632 941967008540 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 941967008541 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 941967008542 MarR family; Region: MarR_2; pfam12802 941967008543 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 941967008544 RNA methyltransferase, RsmE family; Region: TIGR00046 941967008545 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 941967008546 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 941967008547 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 941967008548 generic binding surface II; other site 941967008549 generic binding surface I; other site 941967008550 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 941967008551 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941967008552 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 941967008553 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 941967008554 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 941967008555 hypothetical protein; Reviewed; Region: PRK12275 941967008556 four helix bundle protein; Region: TIGR02436 941967008557 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 941967008558 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 941967008559 Hint domain; Region: Hint_2; pfam13403 941967008560 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 941967008561 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 941967008562 putative DNA binding site [nucleotide binding]; other site 941967008563 putative Zn2+ binding site [ion binding]; other site 941967008564 AsnC family; Region: AsnC_trans_reg; pfam01037 941967008565 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 941967008566 Predicted membrane protein [Function unknown]; Region: COG4541 941967008567 drug efflux system protein MdtG; Provisional; Region: PRK09874 941967008568 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941967008569 putative substrate translocation pore; other site 941967008570 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345 941967008571 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 941967008572 putative NAD(P) binding site [chemical binding]; other site 941967008573 active site 941967008574 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 941967008575 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 941967008576 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 941967008577 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 941967008578 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 941967008579 putative active site [active] 941967008580 phosphogluconate dehydratase; Validated; Region: PRK09054 941967008581 6-phosphogluconate dehydratase; Region: edd; TIGR01196 941967008582 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 941967008583 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 941967008584 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 941967008585 homodimer interface [polypeptide binding]; other site 941967008586 NADP binding site [chemical binding]; other site 941967008587 substrate binding site [chemical binding]; other site 941967008588 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 941967008589 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 941967008590 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 941967008591 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 941967008592 Walker A/P-loop; other site 941967008593 ATP binding site [chemical binding]; other site 941967008594 Q-loop/lid; other site 941967008595 ABC transporter signature motif; other site 941967008596 Walker B; other site 941967008597 D-loop; other site 941967008598 H-loop/switch region; other site 941967008599 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 941967008600 potential frameshift: common BLAST hit: gi|148558432|ref|YP_001257730.1| peptide ABC transporter ATP-binding protein 941967008601 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941967008602 H-loop/switch region; other site 941967008603 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 941967008604 potential frameshift: common BLAST hit: gi|376276562|ref|YP_005152623.1| peptide/nickel transport system ATP-binding protein 941967008605 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941967008606 ABC transporter signature motif; other site 941967008607 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941967008608 Walker A/P-loop; other site 941967008609 ATP binding site [chemical binding]; other site 941967008610 Q-loop/lid; other site 941967008611 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 941967008612 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967008613 dimer interface [polypeptide binding]; other site 941967008614 conserved gate region; other site 941967008615 putative PBP binding loops; other site 941967008616 ABC-ATPase subunit interface; other site 941967008617 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 941967008618 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967008619 dimer interface [polypeptide binding]; other site 941967008620 conserved gate region; other site 941967008621 putative PBP binding loops; other site 941967008622 ABC-ATPase subunit interface; other site 941967008623 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 941967008624 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 941967008625 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 941967008626 active site clefts [active] 941967008627 zinc binding site [ion binding]; other site 941967008628 dimer interface [polypeptide binding]; other site 941967008629 tellurite resistance protein terB; Region: terB; cd07176 941967008630 putative metal binding site [ion binding]; other site 941967008631 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 941967008632 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 941967008633 active site 941967008634 nucleotide binding site [chemical binding]; other site 941967008635 HIGH motif; other site 941967008636 KMSKS motif; other site 941967008637 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 941967008638 Predicted transcriptional regulator [Transcription]; Region: COG2932 941967008639 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 941967008640 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 941967008641 Catalytic site [active] 941967008642 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 941967008643 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 941967008644 substrate binding site [chemical binding]; other site 941967008645 oxyanion hole (OAH) forming residues; other site 941967008646 trimer interface [polypeptide binding]; other site 941967008647 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 941967008648 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 941967008649 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 941967008650 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 941967008651 dimer interface [polypeptide binding]; other site 941967008652 active site 941967008653 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 941967008654 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 941967008655 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 941967008656 FAD binding site [chemical binding]; other site 941967008657 substrate binding site [chemical binding]; other site 941967008658 catalytic residues [active] 941967008659 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 941967008660 potential frameshift: common BLAST hit: gi|340792577|ref|YP_004758041.1| LysR family transcriptional regulator 941967008661 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 941967008662 putative dimerization interface [polypeptide binding]; other site 941967008663 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 941967008664 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 941967008665 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 941967008666 active site 941967008667 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 941967008668 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 941967008669 Walker A/P-loop; other site 941967008670 ATP binding site [chemical binding]; other site 941967008671 Q-loop/lid; other site 941967008672 ABC transporter signature motif; other site 941967008673 Walker B; other site 941967008674 D-loop; other site 941967008675 H-loop/switch region; other site 941967008676 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 941967008677 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 941967008678 Walker A/P-loop; other site 941967008679 ATP binding site [chemical binding]; other site 941967008680 Q-loop/lid; other site 941967008681 ABC transporter signature motif; other site 941967008682 Walker B; other site 941967008683 D-loop; other site 941967008684 H-loop/switch region; other site 941967008685 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 941967008686 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967008687 dimer interface [polypeptide binding]; other site 941967008688 conserved gate region; other site 941967008689 putative PBP binding loops; other site 941967008690 ABC-ATPase subunit interface; other site 941967008691 nickel transporter permease NikB; Provisional; Region: PRK10352 941967008692 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967008693 dimer interface [polypeptide binding]; other site 941967008694 conserved gate region; other site 941967008695 putative PBP binding loops; other site 941967008696 ABC-ATPase subunit interface; other site 941967008697 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 941967008698 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 941967008699 substrate binding site [chemical binding]; other site 941967008700 nickel responsive regulator; Provisional; Region: PRK02967 941967008701 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 941967008702 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 941967008703 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 941967008704 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 941967008705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967008706 dimer interface [polypeptide binding]; other site 941967008707 conserved gate region; other site 941967008708 putative PBP binding loops; other site 941967008709 ABC-ATPase subunit interface; other site 941967008710 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967008711 putative PBP binding loops; other site 941967008712 ABC-ATPase subunit interface; other site 941967008713 ABC transporter; Region: ABC_tran; pfam00005 941967008714 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941967008715 Q-loop/lid; other site 941967008716 ABC transporter signature motif; other site 941967008717 Walker B; other site 941967008718 D-loop; other site 941967008719 H-loop/switch region; other site 941967008720 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 941967008721 hypothetical protein; Provisional; Region: PRK11622 941967008722 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 941967008723 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 941967008724 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 941967008725 Glucuronate isomerase; Region: UxaC; cl00829 941967008726 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 941967008727 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 941967008728 glucuronate isomerase; Reviewed; Region: PRK02925 941967008729 Transcriptional regulators [Transcription]; Region: GntR; COG1802 941967008730 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941967008731 DNA-binding site [nucleotide binding]; DNA binding site 941967008732 FCD domain; Region: FCD; pfam07729 941967008733 mannonate dehydratase; Region: uxuA; TIGR00695 941967008734 mannonate dehydratase; Provisional; Region: PRK03906 941967008735 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 941967008736 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 941967008737 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 941967008738 HlyD family secretion protein; Region: HlyD_3; pfam13437 941967008739 camphor resistance protein CrcB; Provisional; Region: PRK14233 941967008740 camphor resistance protein CrcB; Provisional; Region: PRK14225 941967008741 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 941967008742 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 941967008743 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 941967008744 DNA binding residues [nucleotide binding] 941967008745 putative dimer interface [polypeptide binding]; other site 941967008746 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 941967008747 Sel1-like repeats; Region: SEL1; smart00671 941967008748 Sel1-like repeats; Region: SEL1; smart00671 941967008749 Sel1-like repeats; Region: SEL1; smart00671 941967008750 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 941967008751 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 941967008752 conserved hypothetical protein; Region: alph_Pro_TM; TIGR02186 941967008753 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 941967008754 putative active site [active] 941967008755 putative metal binding site [ion binding]; other site 941967008756 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 941967008757 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 941967008758 ATP binding site [chemical binding]; other site 941967008759 putative Mg++ binding site [ion binding]; other site 941967008760 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941967008761 nucleotide binding region [chemical binding]; other site 941967008762 ATP-binding site [chemical binding]; other site 941967008763 DEAD/H associated; Region: DEAD_assoc; pfam08494 941967008764 ATP-dependent DNA ligase; Validated; Region: PRK09247 941967008765 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 941967008766 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 941967008767 FMN binding site [chemical binding]; other site 941967008768 substrate binding site [chemical binding]; other site 941967008769 putative catalytic residue [active] 941967008770 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 941967008771 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 941967008772 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 941967008773 HsdM N-terminal domain; Region: HsdM_N; pfam12161 941967008774 Methyltransferase domain; Region: Methyltransf_26; pfam13659 941967008775 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 941967008776 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 941967008777 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 941967008778 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 941967008779 ATP binding site [chemical binding]; other site 941967008780 putative Mg++ binding site [ion binding]; other site 941967008781 helicase superfamily c-terminal domain; Region: HELICc; smart00490 941967008782 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 941967008783 Protein of unknown function DUF45; Region: DUF45; pfam01863 941967008784 Protein of unknown function DUF91; Region: DUF91; cl00709 941967008785 Uncharacterized conserved protein [Function unknown]; Region: COG3586 941967008786 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 941967008787 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 941967008788 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 941967008789 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 941967008790 inhibitor-cofactor binding pocket; inhibition site 941967008791 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941967008792 catalytic residue [active] 941967008793 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 941967008794 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941967008795 NAD(P) binding site [chemical binding]; other site 941967008796 active site 941967008797 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 941967008798 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 941967008799 FAD binding domain; Region: FAD_binding_4; pfam01565 941967008800 hypothetical protein; Validated; Region: PRK08238 941967008801 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 941967008802 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 941967008803 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 941967008804 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 941967008805 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 941967008806 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 941967008807 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 941967008808 ligand binding site [chemical binding]; other site 941967008809 dimerization interface [polypeptide binding]; other site 941967008810 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 941967008811 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 941967008812 TM-ABC transporter signature motif; other site 941967008813 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 941967008814 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 941967008815 Walker A/P-loop; other site 941967008816 ATP binding site [chemical binding]; other site 941967008817 Q-loop/lid; other site 941967008818 ABC transporter signature motif; other site 941967008819 Walker B; other site 941967008820 D-loop; other site 941967008821 H-loop/switch region; other site 941967008822 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 941967008823 Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; pfam10054 941967008824 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 941967008825 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 941967008826 putative N- and C-terminal domain interface [polypeptide binding]; other site 941967008827 putative active site [active] 941967008828 MgATP binding site [chemical binding]; other site 941967008829 catalytic site [active] 941967008830 metal binding site [ion binding]; metal-binding site 941967008831 putative xylulose binding site [chemical binding]; other site 941967008832 glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369 941967008833 hydroxyglutarate oxidase; Provisional; Region: PRK11728 941967008834 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 941967008835 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 941967008836 PCI domain; Region: PCI; cl02111 941967008837 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 941967008838 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 941967008839 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 941967008840 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 941967008841 triosephosphate isomerase; Provisional; Region: PRK14565 941967008842 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 941967008843 substrate binding site [chemical binding]; other site 941967008844 dimer interface [polypeptide binding]; other site 941967008845 catalytic triad [active] 941967008846 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 941967008847 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 941967008848 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 941967008849 intersubunit interface [polypeptide binding]; other site 941967008850 active site 941967008851 zinc binding site [ion binding]; other site 941967008852 Na+ binding site [ion binding]; other site 941967008853 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 941967008854 AMP binding site [chemical binding]; other site 941967008855 metal binding site [ion binding]; metal-binding site 941967008856 active site 941967008857 Uncharacterized conserved protein [Function unknown]; Region: COG1739 941967008858 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 941967008859 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 941967008860 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 941967008861 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 941967008862 G1 box; other site 941967008863 putative GEF interaction site [polypeptide binding]; other site 941967008864 GTP/Mg2+ binding site [chemical binding]; other site 941967008865 Switch I region; other site 941967008866 G2 box; other site 941967008867 G3 box; other site 941967008868 Switch II region; other site 941967008869 G4 box; other site 941967008870 G5 box; other site 941967008871 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 941967008872 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 941967008873 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 941967008874 MgtE intracellular N domain; Region: MgtE_N; pfam03448 941967008875 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 941967008876 Divalent cation transporter; Region: MgtE; pfam01769 941967008877 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 941967008878 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 941967008879 active site 941967008880 Zn binding site [ion binding]; other site 941967008881 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 941967008882 dimer interface [polypeptide binding]; other site 941967008883 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 941967008884 Uncharacterized conserved small protein [Function unknown]; Region: COG5515 941967008885 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 941967008886 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 941967008887 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 941967008888 substrate binding site [chemical binding]; other site 941967008889 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 941967008890 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 941967008891 Transcriptional regulators [Transcription]; Region: MarR; COG1846 941967008892 MarR family; Region: MarR; pfam01047 941967008893 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 941967008894 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 941967008895 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941967008896 putative substrate translocation pore; other site 941967008897 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 941967008898 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 941967008899 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 941967008900 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 941967008901 DNA binding site [nucleotide binding] 941967008902 active site 941967008903 tartrate dehydrogenase; Region: TTC; TIGR02089 941967008904 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 941967008905 Uncharacterized conserved protein [Function unknown]; Region: COG2835 941967008906 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 941967008907 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 941967008908 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 941967008909 catalytic residues [active] 941967008910 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 941967008911 putative deacylase active site [active] 941967008912 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 941967008913 apolar tunnel; other site 941967008914 heme binding site [chemical binding]; other site 941967008915 dimerization interface [polypeptide binding]; other site 941967008916 ornithine cyclodeaminase; Validated; Region: PRK07589 941967008917 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 941967008918 Arginase family; Region: Arginase; cd09989 941967008919 agmatinase; Region: agmatinase; TIGR01230 941967008920 active site 941967008921 Mn binding site [ion binding]; other site 941967008922 oligomer interface [polypeptide binding]; other site 941967008923 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 941967008924 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 941967008925 AsnC family; Region: AsnC_trans_reg; pfam01037 941967008926 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 941967008927 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 941967008928 FMN binding site [chemical binding]; other site 941967008929 active site 941967008930 substrate binding site [chemical binding]; other site 941967008931 catalytic residue [active] 941967008932 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 941967008933 dimerization interface [polypeptide binding]; other site 941967008934 putative DNA binding site [nucleotide binding]; other site 941967008935 putative Zn2+ binding site [ion binding]; other site 941967008936 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 941967008937 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 941967008938 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 941967008939 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 941967008940 RNA binding site [nucleotide binding]; other site 941967008941 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 941967008942 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 941967008943 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 941967008944 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941967008945 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 941967008946 dimerization interface [polypeptide binding]; other site 941967008947 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 941967008948 aldehyde dehydrogenase family 7 member; Region: PLN02315 941967008949 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 941967008950 tetrameric interface [polypeptide binding]; other site 941967008951 NAD binding site [chemical binding]; other site 941967008952 catalytic residues [active] 941967008953 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 941967008954 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 941967008955 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 941967008956 putative active site [active] 941967008957 putative substrate binding site [chemical binding]; other site 941967008958 putative cosubstrate binding site; other site 941967008959 catalytic site [active] 941967008960 hypothetical protein; Provisional; Region: PRK02947 941967008961 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 941967008962 putative active site [active] 941967008963 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 941967008964 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 941967008965 active site 941967008966 dimer interface [polypeptide binding]; other site 941967008967 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 941967008968 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 941967008969 dimer interface [polypeptide binding]; other site 941967008970 active site 941967008971 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 941967008972 dimer interface [polypeptide binding]; other site 941967008973 active site 941967008974 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 941967008975 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941967008976 DNA-binding site [nucleotide binding]; DNA binding site 941967008977 UTRA domain; Region: UTRA; pfam07702 941967008978 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 941967008979 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 941967008980 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 941967008981 HlyD family secretion protein; Region: HlyD_3; pfam13437 941967008982 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 941967008983 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 941967008984 HlyD family secretion protein; Region: HlyD_3; pfam13437 941967008985 putative membrane fusion protein; Region: TIGR02828 941967008986 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 941967008987 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 941967008988 putative molybdopterin cofactor binding site [chemical binding]; other site 941967008989 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 941967008990 putative molybdopterin cofactor binding site; other site 941967008991 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 941967008992 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 941967008993 phosphate binding site [ion binding]; other site 941967008994 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 941967008995 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 941967008996 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 941967008997 putative DNA binding site [nucleotide binding]; other site 941967008998 putative Zn2+ binding site [ion binding]; other site 941967008999 AsnC family; Region: AsnC_trans_reg; pfam01037 941967009000 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 941967009001 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 941967009002 active site 941967009003 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 941967009004 dimer interface [polypeptide binding]; other site 941967009005 substrate binding site [chemical binding]; other site 941967009006 catalytic residues [active] 941967009007 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 941967009008 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 941967009009 hydroxyglutarate oxidase; Provisional; Region: PRK11728 941967009010 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 941967009011 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941967009012 non-specific DNA binding site [nucleotide binding]; other site 941967009013 salt bridge; other site 941967009014 sequence-specific DNA binding site [nucleotide binding]; other site 941967009015 Cupin domain; Region: Cupin_2; pfam07883 941967009016 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 941967009017 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941967009018 catalytic residue [active] 941967009019 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 941967009020 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941967009021 DNA-binding site [nucleotide binding]; DNA binding site 941967009022 UTRA domain; Region: UTRA; pfam07702 941967009023 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 941967009024 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 941967009025 active site 941967009026 imidazolonepropionase; Validated; Region: PRK09356 941967009027 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 941967009028 active site 941967009029 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 941967009030 active sites [active] 941967009031 potential frameshift: common BLAST hit: gi|340792702|ref|YP_004758166.1| histidine ammonia-lyase 941967009032 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 941967009033 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 941967009034 N-formylglutamate amidohydrolase; Region: hutG_amidohyd; TIGR02017 941967009035 urocanate hydratase; Provisional; Region: PRK05414 941967009036 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3758 941967009037 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 941967009038 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 941967009039 homodimer interface [polypeptide binding]; other site 941967009040 substrate-cofactor binding pocket; other site 941967009041 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941967009042 catalytic residue [active] 941967009043 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 941967009044 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 941967009045 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 941967009046 TM-ABC transporter signature motif; other site 941967009047 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 941967009048 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 941967009049 Walker A/P-loop; other site 941967009050 ATP binding site [chemical binding]; other site 941967009051 Q-loop/lid; other site 941967009052 ABC transporter signature motif; other site 941967009053 Walker B; other site 941967009054 D-loop; other site 941967009055 H-loop/switch region; other site 941967009056 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 941967009057 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 941967009058 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 941967009059 putative ligand binding site [chemical binding]; other site 941967009060 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 941967009061 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 941967009062 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 941967009063 active site 941967009064 intersubunit interface [polypeptide binding]; other site 941967009065 catalytic residue [active] 941967009066 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 941967009067 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 941967009068 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 941967009069 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 941967009070 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 941967009071 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 941967009072 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 941967009073 Transcriptional regulators [Transcription]; Region: FadR; COG2186 941967009074 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941967009075 DNA-binding site [nucleotide binding]; DNA binding site 941967009076 FCD domain; Region: FCD; pfam07729 941967009077 thiamine pyrophosphate protein; Validated; Region: PRK08199 941967009078 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 941967009079 PYR/PP interface [polypeptide binding]; other site 941967009080 dimer interface [polypeptide binding]; other site 941967009081 TPP binding site [chemical binding]; other site 941967009082 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 941967009083 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 941967009084 TPP-binding site [chemical binding]; other site 941967009085 D-aminopeptidase; Reviewed; Region: PRK13128 941967009086 Beta-lactamase; Region: Beta-lactamase; pfam00144 941967009087 D-aminopeptidase, domain B; Region: DAP_B; pfam07930 941967009088 D-aminopeptidase, domain C; Region: DAP_C; pfam07932 941967009089 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 941967009090 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941967009091 substrate binding pocket [chemical binding]; other site 941967009092 membrane-bound complex binding site; other site 941967009093 hinge residues; other site 941967009094 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 941967009095 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 941967009096 inhibitor-cofactor binding pocket; inhibition site 941967009097 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941967009098 catalytic residue [active] 941967009099 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 941967009100 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 941967009101 active site 941967009102 substrate binding site [chemical binding]; other site 941967009103 ATP binding site [chemical binding]; other site 941967009104 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 941967009105 Peptidase family M23; Region: Peptidase_M23; pfam01551 941967009106 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 941967009107 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 941967009108 AsnC family; Region: AsnC_trans_reg; pfam01037 941967009109 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941967009110 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941967009111 LysR substrate binding domain; Region: LysR_substrate; pfam03466 941967009112 dimerization interface [polypeptide binding]; other site 941967009113 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 941967009114 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 941967009115 putative ligand binding site [chemical binding]; other site 941967009116 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 941967009117 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 941967009118 Walker A/P-loop; other site 941967009119 ATP binding site [chemical binding]; other site 941967009120 Q-loop/lid; other site 941967009121 ABC transporter signature motif; other site 941967009122 Walker B; other site 941967009123 D-loop; other site 941967009124 H-loop/switch region; other site 941967009125 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 941967009126 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 941967009127 Walker A/P-loop; other site 941967009128 ATP binding site [chemical binding]; other site 941967009129 Q-loop/lid; other site 941967009130 ABC transporter signature motif; other site 941967009131 Walker B; other site 941967009132 D-loop; other site 941967009133 H-loop/switch region; other site 941967009134 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 941967009135 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 941967009136 TM-ABC transporter signature motif; other site 941967009137 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 941967009138 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 941967009139 TM-ABC transporter signature motif; other site 941967009140 choline dehydrogenase; Validated; Region: PRK02106 941967009141 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 941967009142 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 941967009143 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 941967009144 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 941967009145 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 941967009146 Walker A/P-loop; other site 941967009147 ATP binding site [chemical binding]; other site 941967009148 Q-loop/lid; other site 941967009149 ABC transporter signature motif; other site 941967009150 Walker B; other site 941967009151 D-loop; other site 941967009152 H-loop/switch region; other site 941967009153 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 941967009154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967009155 dimer interface [polypeptide binding]; other site 941967009156 conserved gate region; other site 941967009157 ABC-ATPase subunit interface; other site 941967009158 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 941967009159 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 941967009160 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 941967009161 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 941967009162 TPR motif; other site 941967009163 binding surface 941967009164 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 941967009165 binding surface 941967009166 TPR motif; other site 941967009167 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 941967009168 binding surface 941967009169 TPR motif; other site 941967009170 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 941967009171 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 941967009172 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 941967009173 putative active site [active] 941967009174 putative catalytic site [active] 941967009175 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 941967009176 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941967009177 motif II; other site 941967009178 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 941967009179 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 941967009180 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 941967009181 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 941967009182 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 941967009183 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 941967009184 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 941967009185 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 941967009186 ligand binding site [chemical binding]; other site 941967009187 homodimer interface [polypeptide binding]; other site 941967009188 NAD(P) binding site [chemical binding]; other site 941967009189 trimer interface B [polypeptide binding]; other site 941967009190 trimer interface A [polypeptide binding]; other site 941967009191 Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835 941967009192 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 941967009193 Beta-lactamase; Region: Beta-lactamase; pfam00144 941967009194 PAS fold; Region: PAS_7; pfam12860 941967009195 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941967009196 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941967009197 metal binding site [ion binding]; metal-binding site 941967009198 active site 941967009199 I-site; other site 941967009200 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 941967009201 short chain dehydrogenase; Provisional; Region: PRK06949 941967009202 classical (c) SDRs; Region: SDR_c; cd05233 941967009203 NAD(P) binding site [chemical binding]; other site 941967009204 active site 941967009205 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 941967009206 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 941967009207 putative ligand binding site [chemical binding]; other site 941967009208 NAD binding site [chemical binding]; other site 941967009209 catalytic site [active] 941967009210 Transcriptional regulators [Transcription]; Region: PurR; COG1609 941967009211 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 941967009212 DNA binding site [nucleotide binding] 941967009213 domain linker motif; other site 941967009214 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 941967009215 putative dimerization interface [polypeptide binding]; other site 941967009216 putative ligand binding site [chemical binding]; other site 941967009217 transcriptional regulator SlyA; Provisional; Region: PRK03573 941967009218 MarR family; Region: MarR_2; cl17246 941967009219 Creatinine amidohydrolase; Region: Creatininase; pfam02633 941967009220 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 941967009221 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 941967009222 P-loop, Walker A motif; other site 941967009223 Base recognition motif; other site 941967009224 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 941967009225 FOG: WD40 repeat [General function prediction only]; Region: COG2319 941967009226 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 941967009227 structural tetrad; other site 941967009228 Predicted esterase [General function prediction only]; Region: COG0400 941967009229 putative hydrolase; Provisional; Region: PRK11460 941967009230 TMAO/DMSO reductase; Reviewed; Region: PRK05363 941967009231 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 941967009232 Moco binding site; other site 941967009233 metal coordination site [ion binding]; other site 941967009234 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 941967009235 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 941967009236 homotrimer interaction site [polypeptide binding]; other site 941967009237 putative active site [active] 941967009238 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 941967009239 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 941967009240 TM-ABC transporter signature motif; other site 941967009241 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 941967009242 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 941967009243 TM-ABC transporter signature motif; other site 941967009244 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 941967009245 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 941967009246 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 941967009247 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 941967009248 Walker A/P-loop; other site 941967009249 ATP binding site [chemical binding]; other site 941967009250 Q-loop/lid; other site 941967009251 ABC transporter signature motif; other site 941967009252 Walker B; other site 941967009253 D-loop; other site 941967009254 H-loop/switch region; other site 941967009255 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 941967009256 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 941967009257 putative ligand binding site [chemical binding]; other site 941967009258 Transcriptional regulator [Transcription]; Region: IclR; COG1414 941967009259 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 941967009260 Bacterial transcriptional regulator; Region: IclR; pfam01614 941967009261 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 941967009262 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 941967009263 N-terminal plug; other site 941967009264 ligand-binding site [chemical binding]; other site 941967009265 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 941967009266 dimer interface [polypeptide binding]; other site 941967009267 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 941967009268 metal binding site [ion binding]; metal-binding site 941967009269 glutathionine S-transferase; Provisional; Region: PRK10542 941967009270 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 941967009271 C-terminal domain interface [polypeptide binding]; other site 941967009272 GSH binding site (G-site) [chemical binding]; other site 941967009273 dimer interface [polypeptide binding]; other site 941967009274 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 941967009275 dimer interface [polypeptide binding]; other site 941967009276 N-terminal domain interface [polypeptide binding]; other site 941967009277 substrate binding pocket (H-site) [chemical binding]; other site 941967009278 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 941967009279 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 941967009280 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941967009281 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941967009282 metal binding site [ion binding]; metal-binding site 941967009283 active site 941967009284 I-site; other site 941967009285 Predicted dehydrogenase [General function prediction only]; Region: COG0579 941967009286 hydroxyglutarate oxidase; Provisional; Region: PRK11728 941967009287 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 941967009288 DNA polymerase III subunit epsilon; Validated; Region: PRK09182 941967009289 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 941967009290 active site 941967009291 catalytic site [active] 941967009292 substrate binding site [chemical binding]; other site 941967009293 amidase; Provisional; Region: PRK07042 941967009294 Amidase; Region: Amidase; cl11426 941967009295 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 941967009296 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 941967009297 Walker A/P-loop; other site 941967009298 ATP binding site [chemical binding]; other site 941967009299 Q-loop/lid; other site 941967009300 ABC transporter signature motif; other site 941967009301 Walker B; other site 941967009302 D-loop; other site 941967009303 H-loop/switch region; other site 941967009304 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 941967009305 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 941967009306 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 941967009307 Walker A/P-loop; other site 941967009308 ATP binding site [chemical binding]; other site 941967009309 Q-loop/lid; other site 941967009310 ABC transporter signature motif; other site 941967009311 Walker B; other site 941967009312 D-loop; other site 941967009313 H-loop/switch region; other site 941967009314 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 941967009315 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 941967009316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967009317 dimer interface [polypeptide binding]; other site 941967009318 conserved gate region; other site 941967009319 putative PBP binding loops; other site 941967009320 ABC-ATPase subunit interface; other site 941967009321 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 941967009322 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967009323 dimer interface [polypeptide binding]; other site 941967009324 conserved gate region; other site 941967009325 putative PBP binding loops; other site 941967009326 ABC-ATPase subunit interface; other site 941967009327 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 941967009328 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 941967009329 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345 941967009330 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 941967009331 putative NAD(P) binding site [chemical binding]; other site 941967009332 active site 941967009333 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 941967009334 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 941967009335 NAD(P) binding site [chemical binding]; other site 941967009336 catalytic residues [active] 941967009337 catalytic residues [active] 941967009338 Transcriptional regulators [Transcription]; Region: GntR; COG1802 941967009339 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941967009340 DNA-binding site [nucleotide binding]; DNA binding site 941967009341 FCD domain; Region: FCD; pfam07729 941967009342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941967009343 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941967009344 putative substrate translocation pore; other site 941967009345 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941967009346 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 941967009347 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 941967009348 homotrimer interaction site [polypeptide binding]; other site 941967009349 putative active site [active] 941967009350 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 941967009351 ribonuclease P; Reviewed; Region: rnpA; PRK01313 941967009352 membrane protein insertase; Provisional; Region: PRK01318 941967009353 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 941967009354 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 941967009355 G1 box; other site 941967009356 GTP/Mg2+ binding site [chemical binding]; other site 941967009357 Switch I region; other site 941967009358 G2 box; other site 941967009359 G3 box; other site 941967009360 Switch II region; other site 941967009361 G4 box; other site 941967009362 G5 box; other site 941967009363 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 941967009364 homohexameric interface [polypeptide binding]; other site 941967009365 feedback inhibition sensing region; other site 941967009366 nucleotide binding site [chemical binding]; other site 941967009367 N-acetyl-L-glutamate binding site [chemical binding]; other site 941967009368 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 941967009369 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 941967009370 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 941967009371 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 941967009372 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 941967009373 trimer interface [polypeptide binding]; other site 941967009374 active site 941967009375 substrate binding site [chemical binding]; other site 941967009376 CoA binding site [chemical binding]; other site 941967009377 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 941967009378 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 941967009379 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 941967009380 metal binding site [ion binding]; metal-binding site 941967009381 dimer interface [polypeptide binding]; other site 941967009382 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 941967009383 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 941967009384 dimerization interface 3.5A [polypeptide binding]; other site 941967009385 active site 941967009386 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 941967009387 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 941967009388 putative active site [active] 941967009389 substrate binding site [chemical binding]; other site 941967009390 putative cosubstrate binding site; other site 941967009391 catalytic site [active] 941967009392 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 941967009393 substrate binding site [chemical binding]; other site 941967009394 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 941967009395 active site 941967009396 catalytic residues [active] 941967009397 metal binding site [ion binding]; metal-binding site 941967009398 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 941967009399 RmuC family; Region: RmuC; pfam02646 941967009400 Rdx family; Region: Rdx; cl01407 941967009401 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 941967009402 catalytic site [active] 941967009403 metal binding site [ion binding]; metal-binding site 941967009404 GTP-binding protein LepA; Provisional; Region: PRK05433 941967009405 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 941967009406 G1 box; other site 941967009407 putative GEF interaction site [polypeptide binding]; other site 941967009408 GTP/Mg2+ binding site [chemical binding]; other site 941967009409 Switch I region; other site 941967009410 G2 box; other site 941967009411 G3 box; other site 941967009412 Switch II region; other site 941967009413 G4 box; other site 941967009414 G5 box; other site 941967009415 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 941967009416 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 941967009417 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 941967009418 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 941967009419 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 941967009420 putative NAD(P) binding site [chemical binding]; other site 941967009421 active site 941967009422 Undecaprenyl pyrophosphate phosphatase [Lipid transport and metabolism]; Region: BacA; COG1968 941967009423 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 941967009424 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 941967009425 C-terminal domain interface [polypeptide binding]; other site 941967009426 GSH binding site (G-site) [chemical binding]; other site 941967009427 dimer interface [polypeptide binding]; other site 941967009428 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 941967009429 N-terminal domain interface [polypeptide binding]; other site 941967009430 dimer interface [polypeptide binding]; other site 941967009431 substrate binding pocket (H-site) [chemical binding]; other site 941967009432 epoxyqueuosine reductase; Region: TIGR00276 941967009433 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 941967009434 HEAT repeat; Region: HEAT; pfam02985 941967009435 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 941967009436 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 941967009437 putative NAD(P) binding site [chemical binding]; other site 941967009438 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 941967009439 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 941967009440 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 941967009441 active site 941967009442 dimer interfaces [polypeptide binding]; other site 941967009443 catalytic residues [active] 941967009444 Glucokinase [Carbohydrate transport and metabolism]; Region: Glk; COG0837 941967009445 glucokinase, proteobacterial type; Region: glk; TIGR00749 941967009446 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 941967009447 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 941967009448 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 941967009449 Walker A/P-loop; other site 941967009450 ATP binding site [chemical binding]; other site 941967009451 Q-loop/lid; other site 941967009452 ABC transporter signature motif; other site 941967009453 Walker B; other site 941967009454 D-loop; other site 941967009455 H-loop/switch region; other site 941967009456 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 941967009457 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 941967009458 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 941967009459 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 941967009460 catalytic core [active] 941967009461 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 941967009462 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 941967009463 active site 941967009464 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 941967009465 putative FMN binding site [chemical binding]; other site 941967009466 Predicted membrane protein [Function unknown]; Region: COG3714 941967009467 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 941967009468 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 941967009469 NAD(P) binding site [chemical binding]; other site 941967009470 catalytic residues [active] 941967009471 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 941967009472 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 941967009473 putative catalytic site [active] 941967009474 putative metal binding site [ion binding]; other site 941967009475 putative phosphate binding site [ion binding]; other site 941967009476 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 941967009477 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 941967009478 putative active site [active] 941967009479 catalytic site [active] 941967009480 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 941967009481 putative active site [active] 941967009482 catalytic site [active] 941967009483 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 941967009484 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 941967009485 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 941967009486 G1 box; other site 941967009487 putative GEF interaction site [polypeptide binding]; other site 941967009488 GTP/Mg2+ binding site [chemical binding]; other site 941967009489 Switch I region; other site 941967009490 G2 box; other site 941967009491 G3 box; other site 941967009492 Switch II region; other site 941967009493 G4 box; other site 941967009494 G5 box; other site 941967009495 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 941967009496 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 941967009497 Flavoprotein; Region: Flavoprotein; pfam02441 941967009498 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 941967009499 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 941967009500 ABC1 family; Region: ABC1; pfam03109 941967009501 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 941967009502 active site 941967009503 ATP binding site [chemical binding]; other site 941967009504 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 941967009505 substrate binding site [chemical binding]; other site 941967009506 activation loop (A-loop); other site 941967009507 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 941967009508 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941967009509 S-adenosylmethionine binding site [chemical binding]; other site 941967009510 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 941967009511 active site 941967009512 hypothetical protein; Provisional; Region: PRK00736 941967009513 methionine sulfoxide reductase A; Provisional; Region: PRK00058 941967009514 putative transposase OrfB; Reviewed; Region: PHA02517 941967009515 HTH-like domain; Region: HTH_21; pfam13276 941967009516 Integrase core domain; Region: rve; pfam00665 941967009517 Integrase core domain; Region: rve_3; pfam13683 941967009518 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 941967009519 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 941967009520 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235 941967009521 intersubunit interface [polypeptide binding]; other site 941967009522 active site 941967009523 Zn2+ binding site [ion binding]; other site 941967009524 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 941967009525 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 941967009526 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 941967009527 catalytic residue [active] 941967009528 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 941967009529 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941967009530 Walker A/P-loop; other site 941967009531 ATP binding site [chemical binding]; other site 941967009532 Q-loop/lid; other site 941967009533 ABC transporter signature motif; other site 941967009534 Walker B; other site 941967009535 D-loop; other site 941967009536 H-loop/switch region; other site 941967009537 TOBE domain; Region: TOBE_2; pfam08402 941967009538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967009539 dimer interface [polypeptide binding]; other site 941967009540 conserved gate region; other site 941967009541 putative PBP binding loops; other site 941967009542 ABC-ATPase subunit interface; other site 941967009543 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 941967009544 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967009545 dimer interface [polypeptide binding]; other site 941967009546 conserved gate region; other site 941967009547 putative PBP binding loops; other site 941967009548 ABC-ATPase subunit interface; other site 941967009549 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 941967009550 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 941967009551 amidase; Provisional; Region: PRK07486 941967009552 Amidase; Region: Amidase; cl11426 941967009553 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 941967009554 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 941967009555 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 941967009556 Walker A/P-loop; other site 941967009557 ATP binding site [chemical binding]; other site 941967009558 Q-loop/lid; other site 941967009559 ABC transporter signature motif; other site 941967009560 Walker B; other site 941967009561 D-loop; other site 941967009562 H-loop/switch region; other site 941967009563 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 941967009564 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 941967009565 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 941967009566 Walker A/P-loop; other site 941967009567 ATP binding site [chemical binding]; other site 941967009568 Q-loop/lid; other site 941967009569 ABC transporter signature motif; other site 941967009570 Walker B; other site 941967009571 D-loop; other site 941967009572 H-loop/switch region; other site 941967009573 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 941967009574 potential frameshift: common BLAST hit: gi|376279041|ref|YP_005109074.1| peptide ABC transporter, permease protein, putative 941967009575 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 941967009576 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 941967009577 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967009578 dimer interface [polypeptide binding]; other site 941967009579 ABC-ATPase subunit interface; other site 941967009580 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 941967009581 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967009582 dimer interface [polypeptide binding]; other site 941967009583 conserved gate region; other site 941967009584 putative PBP binding loops; other site 941967009585 ABC-ATPase subunit interface; other site 941967009586 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 941967009587 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 941967009588 Transcriptional regulators [Transcription]; Region: GntR; COG1802 941967009589 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 941967009590 DNA-binding site [nucleotide binding]; DNA binding site 941967009591 FCD domain; Region: FCD; pfam07729 941967009592 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 941967009593 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 941967009594 Walker A/P-loop; other site 941967009595 ATP binding site [chemical binding]; other site 941967009596 Q-loop/lid; other site 941967009597 ABC transporter signature motif; other site 941967009598 Walker B; other site 941967009599 D-loop; other site 941967009600 H-loop/switch region; other site 941967009601 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 941967009602 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 941967009603 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 941967009604 Walker A/P-loop; other site 941967009605 ATP binding site [chemical binding]; other site 941967009606 Q-loop/lid; other site 941967009607 ABC transporter signature motif; other site 941967009608 Walker B; other site 941967009609 D-loop; other site 941967009610 H-loop/switch region; other site 941967009611 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 941967009612 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 941967009613 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967009614 dimer interface [polypeptide binding]; other site 941967009615 conserved gate region; other site 941967009616 putative PBP binding loops; other site 941967009617 ABC-ATPase subunit interface; other site 941967009618 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 941967009619 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967009620 dimer interface [polypeptide binding]; other site 941967009621 conserved gate region; other site 941967009622 putative PBP binding loops; other site 941967009623 ABC-ATPase subunit interface; other site 941967009624 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 941967009625 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 941967009626 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 941967009627 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 941967009628 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 941967009629 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 941967009630 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 941967009631 active site 941967009632 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 941967009633 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 941967009634 active site 941967009635 enoyl-CoA hydratase; Provisional; Region: PRK08138 941967009636 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 941967009637 substrate binding site [chemical binding]; other site 941967009638 oxyanion hole (OAH) forming residues; other site 941967009639 trimer interface [polypeptide binding]; other site 941967009640 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 941967009641 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 941967009642 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 941967009643 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 941967009644 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 941967009645 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 941967009646 tetramer interface [polypeptide binding]; other site 941967009647 TPP-binding site [chemical binding]; other site 941967009648 heterodimer interface [polypeptide binding]; other site 941967009649 phosphorylation loop region [posttranslational modification] 941967009650 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 941967009651 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 941967009652 alpha subunit interface [polypeptide binding]; other site 941967009653 TPP binding site [chemical binding]; other site 941967009654 heterodimer interface [polypeptide binding]; other site 941967009655 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 941967009656 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 941967009657 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 941967009658 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 941967009659 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 941967009660 E3 interaction surface; other site 941967009661 lipoyl attachment site [posttranslational modification]; other site 941967009662 e3 binding domain; Region: E3_binding; pfam02817 941967009663 Serine hydrolase; Region: Ser_hydrolase; cl17834 941967009664 Transcriptional regulator [Transcription]; Region: IclR; COG1414 941967009665 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 941967009666 Bacterial transcriptional regulator; Region: IclR; pfam01614 941967009667 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 941967009668 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967009669 dimer interface [polypeptide binding]; other site 941967009670 conserved gate region; other site 941967009671 putative PBP binding loops; other site 941967009672 ABC-ATPase subunit interface; other site 941967009673 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 941967009674 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 941967009675 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 941967009676 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 941967009677 Walker A/P-loop; other site 941967009678 ATP binding site [chemical binding]; other site 941967009679 Q-loop/lid; other site 941967009680 ABC transporter signature motif; other site 941967009681 Walker B; other site 941967009682 D-loop; other site 941967009683 H-loop/switch region; other site 941967009684 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 941967009685 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 941967009686 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 941967009687 Walker A/P-loop; other site 941967009688 ATP binding site [chemical binding]; other site 941967009689 Q-loop/lid; other site 941967009690 ABC transporter signature motif; other site 941967009691 Walker B; other site 941967009692 D-loop; other site 941967009693 H-loop/switch region; other site 941967009694 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 941967009695 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 941967009696 CoA-transferase family III; Region: CoA_transf_3; pfam02515 941967009697 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 941967009698 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 941967009699 tetramerization interface [polypeptide binding]; other site 941967009700 NAD(P) binding site [chemical binding]; other site 941967009701 catalytic residues [active] 941967009702 Transcriptional regulators [Transcription]; Region: GntR; COG1802 941967009703 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941967009704 DNA-binding site [nucleotide binding]; DNA binding site 941967009705 FCD domain; Region: FCD; pfam07729 941967009706 putative transposase OrfB; Reviewed; Region: PHA02517 941967009707 HTH-like domain; Region: HTH_21; pfam13276 941967009708 Integrase core domain; Region: rve; pfam00665 941967009709 Integrase core domain; Region: rve_3; pfam13683 941967009710 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 941967009711 Rrf2 family protein; Region: rrf2_super; TIGR00738 941967009712 Transcriptional regulator; Region: Rrf2; pfam02082 941967009713 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 941967009714 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 941967009715 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 941967009716 ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531 941967009717 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 941967009718 metal binding site [ion binding]; metal-binding site 941967009719 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 941967009720 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 941967009721 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 941967009722 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 941967009723 ABC-ATPase subunit interface; other site 941967009724 dimer interface [polypeptide binding]; other site 941967009725 putative PBP binding regions; other site 941967009726 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 941967009727 metal binding site 2 [ion binding]; metal-binding site 941967009728 putative DNA binding helix; other site 941967009729 metal binding site 1 [ion binding]; metal-binding site 941967009730 dimer interface [polypeptide binding]; other site 941967009731 structural Zn2+ binding site [ion binding]; other site 941967009732 FlgN protein; Region: FlgN; pfam05130 941967009733 Rod binding protein; Region: Rod-binding; pfam10135 941967009734 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 941967009735 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 941967009736 FHIPEP family; Region: FHIPEP; pfam00771 941967009737 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 941967009738 flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010 941967009739 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009 941967009740 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 941967009741 Flagellar biosynthesis regulator FlbT [Cell motility and secretion]; Region: FlbT; COG5443 941967009742 Flagellar biosynthesis regulator FlaF [Cell motility and secretion]; Region: FlaF; COG5442 941967009743 flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793 941967009744 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008 941967009745 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 941967009746 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 941967009747 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 941967009748 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 941967009749 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 941967009750 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 941967009751 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 941967009752 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 941967009753 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941967009754 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941967009755 DNA binding site [nucleotide binding] 941967009756 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 941967009757 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 941967009758 N-acetyl-D-glucosamine binding site [chemical binding]; other site 941967009759 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 941967009760 chemotaxis protein; Reviewed; Region: PRK12798 941967009761 flagellar motor protein MotB; Validated; Region: motB; PRK05996 941967009762 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 941967009763 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 941967009764 ligand binding site [chemical binding]; other site 941967009765 Flagellar basal body M-ring protein [Cell motility and secretion]; Region: fliF; COG1766 941967009766 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 941967009767 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 941967009768 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 941967009769 flagellin; Reviewed; Region: PRK12687 941967009770 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 941967009771 potential frameshift: common BLAST hit: gi|376270493|ref|YP_005113538.1| Type V secretory pathway, adhesin AidA 941967009772 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 941967009773 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 941967009774 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 941967009775 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 941967009776 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 941967009777 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 941967009778 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 941967009779 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 941967009780 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 941967009781 Autotransporter beta-domain; Region: Autotransporter; smart00869 941967009782 Uncharacterized conserved protein [Function unknown]; Region: COG3268 941967009783 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 941967009784 D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634 941967009785 putative ligand binding site [chemical binding]; other site 941967009786 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 941967009787 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 941967009788 Walker A/P-loop; other site 941967009789 ATP binding site [chemical binding]; other site 941967009790 Q-loop/lid; other site 941967009791 ABC transporter signature motif; other site 941967009792 Walker B; other site 941967009793 D-loop; other site 941967009794 H-loop/switch region; other site 941967009795 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 941967009796 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 941967009797 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 941967009798 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 941967009799 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 941967009800 TM-ABC transporter signature motif; other site 941967009801 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 941967009802 HTH domain; Region: HTH_11; cl17392 941967009803 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941967009804 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 941967009805 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 941967009806 NAD(P) binding site [chemical binding]; other site 941967009807 catalytic residues [active] 941967009808 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 941967009809 choline dehydrogenase; Validated; Region: PRK02106 941967009810 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Region: HpaI; TIGR02311 941967009811 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 941967009812 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 941967009813 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 941967009814 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 941967009815 N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266 941967009816 tetramer interface [polypeptide binding]; other site 941967009817 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 941967009818 tetramer interface [polypeptide binding]; other site 941967009819 active site 941967009820 metal binding site [ion binding]; metal-binding site 941967009821 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 941967009822 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 941967009823 NAD binding site [chemical binding]; other site 941967009824 catalytic residues [active] 941967009825 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 941967009826 putative substrate binding pocket [chemical binding]; other site 941967009827 trimer interface [polypeptide binding]; other site 941967009828 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 941967009829 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 941967009830 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 941967009831 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 941967009832 active site 941967009833 ATP binding site [chemical binding]; other site 941967009834 substrate binding site [chemical binding]; other site 941967009835 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 941967009836 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 941967009837 inhibitor-cofactor binding pocket; inhibition site 941967009838 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941967009839 catalytic residue [active] 941967009840 hypothetical protein; Provisional; Region: PRK07481 941967009841 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 941967009842 inhibitor-cofactor binding pocket; inhibition site 941967009843 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941967009844 catalytic residue [active] 941967009845 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 941967009846 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941967009847 motif II; other site 941967009848 Uncharacterized conserved protein [Function unknown]; Region: COG5441; cl02262 941967009849 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 941967009850 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 941967009851 Transcriptional regulator [Transcription]; Region: IclR; COG1414 941967009852 Bacterial transcriptional regulator; Region: IclR; pfam01614 941967009853 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 941967009854 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 941967009855 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 941967009856 NAD(P) binding site [chemical binding]; other site 941967009857 catalytic residues [active] 941967009858 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 941967009859 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 941967009860 active site 941967009861 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 941967009862 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 941967009863 putative ligand binding site [chemical binding]; other site 941967009864 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 941967009865 TM-ABC transporter signature motif; other site 941967009866 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 941967009867 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 941967009868 TM-ABC transporter signature motif; other site 941967009869 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 941967009870 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 941967009871 Walker A/P-loop; other site 941967009872 ATP binding site [chemical binding]; other site 941967009873 Q-loop/lid; other site 941967009874 ABC transporter signature motif; other site 941967009875 Walker B; other site 941967009876 D-loop; other site 941967009877 H-loop/switch region; other site 941967009878 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 941967009879 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 941967009880 Walker A/P-loop; other site 941967009881 ATP binding site [chemical binding]; other site 941967009882 Q-loop/lid; other site 941967009883 ABC transporter signature motif; other site 941967009884 Walker B; other site 941967009885 D-loop; other site 941967009886 H-loop/switch region; other site 941967009887 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 941967009888 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 941967009889 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 941967009890 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941967009891 DNA-binding site [nucleotide binding]; DNA binding site 941967009892 UTRA domain; Region: UTRA; pfam07702 941967009893 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 941967009894 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 941967009895 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 941967009896 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967009897 dimer interface [polypeptide binding]; other site 941967009898 conserved gate region; other site 941967009899 putative PBP binding loops; other site 941967009900 ABC-ATPase subunit interface; other site 941967009901 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967009902 dimer interface [polypeptide binding]; other site 941967009903 conserved gate region; other site 941967009904 putative PBP binding loops; other site 941967009905 ABC-ATPase subunit interface; other site 941967009906 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 941967009907 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941967009908 Walker A/P-loop; other site 941967009909 ATP binding site [chemical binding]; other site 941967009910 Q-loop/lid; other site 941967009911 ABC transporter signature motif; other site 941967009912 Walker B; other site 941967009913 D-loop; other site 941967009914 H-loop/switch region; other site 941967009915 TOBE domain; Region: TOBE_2; pfam08402 941967009916 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 941967009917 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 941967009918 active site 941967009919 metal binding site [ion binding]; metal-binding site 941967009920 potential frameshift: common BLAST hit: gi|225686926|ref|YP_002734898.1| arylsulfatase D 941967009921 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 941967009922 Sulfatase; Region: Sulfatase; cl17466 941967009923 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 941967009924 Sulfatase; Region: Sulfatase; cl17466 941967009925 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 941967009926 NMT1-like family; Region: NMT1_2; pfam13379 941967009927 substrate binding pocket [chemical binding]; other site 941967009928 membrane-bound complex binding site; other site 941967009929 hinge residues; other site 941967009930 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 941967009931 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 941967009932 Walker A/P-loop; other site 941967009933 ATP binding site [chemical binding]; other site 941967009934 Q-loop/lid; other site 941967009935 ABC transporter signature motif; other site 941967009936 Walker B; other site 941967009937 D-loop; other site 941967009938 H-loop/switch region; other site 941967009939 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 941967009940 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941967009941 dimer interface [polypeptide binding]; other site 941967009942 conserved gate region; other site 941967009943 putative PBP binding loops; other site 941967009944 ABC-ATPase subunit interface; other site 941967009945 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 941967009946 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 941967009947 nucleotide binding site [chemical binding]; other site 941967009948 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 941967009949 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 941967009950 N-terminal plug; other site 941967009951 ligand-binding site [chemical binding]; other site 941967009952 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 941967009953 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941967009954 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 941967009955 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_5; cd06338 941967009956 putative ligand binding site [chemical binding]; other site 941967009957 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 941967009958 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 941967009959 TM-ABC transporter signature motif; other site 941967009960 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 941967009961 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 941967009962 TM-ABC transporter signature motif; other site 941967009963 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 941967009964 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941967009965 Walker A/P-loop; other site 941967009966 ATP binding site [chemical binding]; other site 941967009967 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 941967009968 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941967009969 ABC transporter signature motif; other site 941967009970 Walker B; other site 941967009971 D-loop; other site 941967009972 H-loop/switch region; other site 941967009973 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 941967009974 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 941967009975 Walker A/P-loop; other site 941967009976 ATP binding site [chemical binding]; other site 941967009977 Q-loop/lid; other site 941967009978 ABC transporter signature motif; other site 941967009979 Walker B; other site 941967009980 D-loop; other site 941967009981 H-loop/switch region; other site 941967009982 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 941967009983 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 941967009984 Soluble P-type ATPase [General function prediction only]; Region: COG4087 941967009985 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 941967009986 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941967009987 FeS/SAM binding site; other site 941967009988 HemN C-terminal domain; Region: HemN_C; pfam06969 941967009989 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 941967009990 MerR family regulatory protein; Region: MerR; pfam00376 941967009991 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 941967009992 P-loop; other site 941967009993 Magnesium ion binding site [ion binding]; other site 941967009994 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 941967009995 P-loop; other site 941967009996 Magnesium ion binding site [ion binding]; other site 941967009997 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 941967009998 ParB-like nuclease domain; Region: ParB; smart00470