-- dump date   	20140619_011148
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
703352000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
703352000002	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
703352000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
703352000004	Walker A motif; other site
703352000005	ATP binding site [chemical binding]; other site
703352000006	Walker B motif; other site
703352000007	arginine finger; other site
703352000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
703352000009	DnaA box-binding interface [nucleotide binding]; other site
703352000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
703352000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
703352000012	putative DNA binding surface [nucleotide binding]; other site
703352000013	dimer interface [polypeptide binding]; other site
703352000014	beta-clamp/clamp loader binding surface; other site
703352000015	beta-clamp/translesion DNA polymerase binding surface; other site
703352000016	recombination protein F; Reviewed; Region: recF; PRK00064
703352000017	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
703352000018	Walker A/P-loop; other site
703352000019	ATP binding site [chemical binding]; other site
703352000020	Q-loop/lid; other site
703352000021	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
703352000022	ABC transporter signature motif; other site
703352000023	Walker B; other site
703352000024	D-loop; other site
703352000025	H-loop/switch region; other site
703352000026	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
703352000027	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
703352000028	ATP binding site [chemical binding]; other site
703352000029	substrate interface [chemical binding]; other site
703352000030	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
703352000031	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
703352000032	putative ligand binding site [chemical binding]; other site
703352000033	NAD binding site [chemical binding]; other site
703352000034	dimerization interface [polypeptide binding]; other site
703352000035	catalytic site [active]
703352000036	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
703352000037	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
703352000038	Walker A/P-loop; other site
703352000039	ATP binding site [chemical binding]; other site
703352000040	Q-loop/lid; other site
703352000041	ABC transporter signature motif; other site
703352000042	Walker B; other site
703352000043	D-loop; other site
703352000044	H-loop/switch region; other site
703352000045	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
703352000046	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
703352000047	Walker A/P-loop; other site
703352000048	ATP binding site [chemical binding]; other site
703352000049	Q-loop/lid; other site
703352000050	ABC transporter signature motif; other site
703352000051	Walker B; other site
703352000052	D-loop; other site
703352000053	H-loop/switch region; other site
703352000054	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
703352000055	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
703352000056	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
703352000057	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352000058	dimer interface [polypeptide binding]; other site
703352000059	conserved gate region; other site
703352000060	putative PBP binding loops; other site
703352000061	ABC-ATPase subunit interface; other site
703352000062	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
703352000063	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352000064	dimer interface [polypeptide binding]; other site
703352000065	conserved gate region; other site
703352000066	putative PBP binding loops; other site
703352000067	ABC-ATPase subunit interface; other site
703352000068	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
703352000069	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
703352000070	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
703352000071	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
703352000072	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
703352000073	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
703352000074	dimerization interface [polypeptide binding]; other site
703352000075	ligand binding site [chemical binding]; other site
703352000076	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
703352000077	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
703352000078	substrate binding site [chemical binding]; other site
703352000079	oxyanion hole (OAH) forming residues; other site
703352000080	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
703352000081	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
703352000082	active site
703352000083	catalytic residues [active]
703352000084	metal binding site [ion binding]; metal-binding site
703352000085	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
703352000086	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
703352000087	ATP-grasp domain; Region: ATP-grasp_4; cl17255
703352000088	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
703352000089	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
703352000090	carboxyltransferase (CT) interaction site; other site
703352000091	biotinylation site [posttranslational modification]; other site
703352000092	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
703352000093	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
703352000094	isovaleryl-CoA dehydrogenase; Region: PLN02519
703352000095	substrate binding site [chemical binding]; other site
703352000096	FAD binding site [chemical binding]; other site
703352000097	catalytic base [active]
703352000098	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
703352000099	active site
703352000100	CoA binding site [chemical binding]; other site
703352000101	AMP binding site [chemical binding]; other site
703352000102	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
703352000103	acyl-activating enzyme (AAE) consensus motif; other site
703352000104	CHRD domain; Region: CHRD; pfam07452
703352000105	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
703352000106	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4530
703352000107	Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538
703352000108	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
703352000109	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
703352000110	hinge; other site
703352000111	active site
703352000112	cytidylate kinase; Provisional; Region: cmk; PRK00023
703352000113	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
703352000114	CMP-binding site; other site
703352000115	The sites determining sugar specificity; other site
703352000116	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
703352000117	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
703352000118	RNA binding site [nucleotide binding]; other site
703352000119	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
703352000120	RNA binding site [nucleotide binding]; other site
703352000121	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
703352000122	RNA binding site [nucleotide binding]; other site
703352000123	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
703352000124	RNA binding site [nucleotide binding]; other site
703352000125	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
703352000126	RNA binding site [nucleotide binding]; other site
703352000127	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
703352000128	RNA binding site [nucleotide binding]; other site
703352000129	Predicted membrane protein [Function unknown]; Region: COG2855
703352000130	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
703352000131	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
703352000132	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
703352000133	putative dimerization interface [polypeptide binding]; other site
703352000134	lytic murein transglycosylase; Region: MltB_2; TIGR02283
703352000135	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
703352000136	N-acetyl-D-glucosamine binding site [chemical binding]; other site
703352000137	recombination protein RecR; Reviewed; Region: recR; PRK00076
703352000138	RecR protein; Region: RecR; pfam02132
703352000139	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
703352000140	putative active site [active]
703352000141	putative metal-binding site [ion binding]; other site
703352000142	tetramer interface [polypeptide binding]; other site
703352000143	hypothetical protein; Validated; Region: PRK00153
703352000144	DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111
703352000145	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
703352000146	Walker A motif; other site
703352000147	ATP binding site [chemical binding]; other site
703352000148	Walker B motif; other site
703352000149	arginine finger; other site
703352000150	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
703352000151	DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362
703352000152	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
703352000153	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
703352000154	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
703352000155	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
703352000156	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
703352000157	putative NADH binding site [chemical binding]; other site
703352000158	putative active site [active]
703352000159	nudix motif; other site
703352000160	putative metal binding site [ion binding]; other site
703352000161	prephenate dehydratase; Provisional; Region: PRK11899
703352000162	Prephenate dehydratase; Region: PDT; pfam00800
703352000163	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
703352000164	putative L-Phe binding site [chemical binding]; other site
703352000165	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
703352000166	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
703352000167	Ligand binding site; other site
703352000168	oligomer interface; other site
703352000169	Cytochrome c2 [Energy production and conversion]; Region: COG3474
703352000170	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
703352000171	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
703352000172	putative MPT binding site; other site
703352000173	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
703352000174	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
703352000175	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
703352000176	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
703352000177	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
703352000178	D-pathway; other site
703352000179	Putative ubiquinol binding site [chemical binding]; other site
703352000180	Low-spin heme (heme b) binding site [chemical binding]; other site
703352000181	Putative water exit pathway; other site
703352000182	Binuclear center (heme o3/CuB) [ion binding]; other site
703352000183	K-pathway; other site
703352000184	Putative proton exit pathway; other site
703352000185	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
703352000186	Subunit I/III interface [polypeptide binding]; other site
703352000187	Subunit III/IV interface [polypeptide binding]; other site
703352000188	Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125
703352000189	Bacterial SH3 domain; Region: SH3_3; pfam08239
703352000190	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
703352000191	Surface antigen; Region: Bac_surface_Ag; pfam01103
703352000192	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
703352000193	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
703352000194	Family of unknown function (DUF490); Region: DUF490; pfam04357
703352000195	potential frameshift: common BLAST hit: gi|376279753|ref|YP_005153759.1| putative lipoprotein
703352000196	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
703352000197	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
703352000198	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
703352000199	Copper(I)-binding protein [Inorganic ion transport and    metabolism]; Region: COG2847
703352000200	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
703352000201	dimer interface [polypeptide binding]; other site
703352000202	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
703352000203	active site
703352000204	metal binding site [ion binding]; metal-binding site
703352000205	glutathione binding site [chemical binding]; other site
703352000206	Domain of unknown function DUF59; Region: DUF59; pfam01883
703352000207	cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969
703352000208	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
703352000209	Walker A motif; other site
703352000210	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
703352000211	phosphoglucomutase; Region: PLN02307
703352000212	Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085
703352000213	substrate binding site [chemical binding]; other site
703352000214	dimer interface [polypeptide binding]; other site
703352000215	active site
703352000216	metal binding site [ion binding]; metal-binding site
703352000217	Transcriptional regulator [Transcription]; Region: LysR; COG0583
703352000218	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
703352000219	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
703352000220	putative effector binding pocket; other site
703352000221	putative dimerization interface [polypeptide binding]; other site
703352000222	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
703352000223	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
703352000224	nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270
703352000225	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
703352000226	active site
703352000227	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
703352000228	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
703352000229	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
703352000230	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
703352000231	N-acetyl-D-glucosamine binding site [chemical binding]; other site
703352000232	catalytic residue [active]
703352000233	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
703352000234	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
703352000235	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
703352000236	putative active site [active]
703352000237	putative PHP Thumb interface [polypeptide binding]; other site
703352000238	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
703352000239	generic binding surface II; other site
703352000240	generic binding surface I; other site
703352000241	DNA Polymerase Y-family; Region: PolY_like; cd03468
703352000242	active site
703352000243	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
703352000244	DNA binding site [nucleotide binding]
703352000245	Uncharacterized conserved protein [Function unknown]; Region: COG4544
703352000246	Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295
703352000247	Haemagglutinin; Region: HIM; pfam05662
703352000248	Haemagglutinin; Region: HIM; pfam05662
703352000249	Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295
703352000250	Haemagglutinin; Region: HIM; pfam05662
703352000251	Haemagglutinin; Region: HIM; pfam05662
703352000252	YadA-like C-terminal region; Region: YadA; pfam03895
703352000253	argininosuccinate synthase; Provisional; Region: PRK13820
703352000254	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
703352000255	ANP binding site [chemical binding]; other site
703352000256	Substrate Binding Site II [chemical binding]; other site
703352000257	Substrate Binding Site I [chemical binding]; other site
703352000258	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
703352000259	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
703352000260	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
703352000261	FeS/SAM binding site; other site
703352000262	Invasion associated locus B (IalB) protein; Region: IalB; cl02207
703352000263	Uncharacterized conserved protein [Function unknown]; Region: COG3339
703352000264	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914
703352000265	aromatic arch; other site
703352000266	DCoH dimer interaction site [polypeptide binding]; other site
703352000267	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
703352000268	DCoH tetramer interaction site [polypeptide binding]; other site
703352000269	substrate binding site [chemical binding]; other site
703352000270	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
703352000271	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
703352000272	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
703352000273	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
703352000274	active site
703352000275	catalytic triad [active]
703352000276	oxyanion hole [active]
703352000277	switch loop; other site
703352000278	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
703352000279	H-loop/switch region; other site
703352000280	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
703352000281	FtsX-like permease family; Region: FtsX; pfam02687
703352000282	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
703352000283	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
703352000284	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
703352000285	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
703352000286	Coenzyme A binding pocket [chemical binding]; other site
703352000287	Protein of unknown function (DUF2794); Region: DUF2794; pfam10984
703352000288	Uncharacterized secreted protein [Function unknown]; Region: COG5429
703352000289	aconitate hydratase; Validated; Region: PRK09277
703352000290	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
703352000291	substrate binding site [chemical binding]; other site
703352000292	ligand binding site [chemical binding]; other site
703352000293	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
703352000294	substrate binding site [chemical binding]; other site
703352000295	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539
703352000296	Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231
703352000297	Walker A/P-loop; other site
703352000298	ATP binding site [chemical binding]; other site
703352000299	Q-loop/lid; other site
703352000300	ABC transporter signature motif; other site
703352000301	Walker B; other site
703352000302	D-loop; other site
703352000303	H-loop/switch region; other site
703352000304	ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmB; COG2386
703352000305	heme exporter protein CcmC; Region: ccmC; TIGR01191
703352000306	heme exporter protein CcmD; Region: cytochro_ccmD; TIGR03141
703352000307	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
703352000308	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
703352000309	catalytic residues [active]
703352000310	central insert; other site
703352000311	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
703352000312	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
703352000313	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
703352000314	active site
703352000315	phosphorylation site [posttranslational modification]
703352000316	intermolecular recognition site; other site
703352000317	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
703352000318	AsnC family; Region: AsnC_trans_reg; pfam01037
703352000319	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
703352000320	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
703352000321	active site
703352000322	metal binding site [ion binding]; metal-binding site
703352000323	Domain of Unknown Function (DUF930); Region: DUF930; pfam06059
703352000324	Uncharacterized conserved protein [Function unknown]; Region: COG1434
703352000325	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
703352000326	putative active site [active]
703352000327	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
703352000328	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
703352000329	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
703352000330	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352000331	dimer interface [polypeptide binding]; other site
703352000332	conserved gate region; other site
703352000333	putative PBP binding loops; other site
703352000334	ABC-ATPase subunit interface; other site
703352000335	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352000336	dimer interface [polypeptide binding]; other site
703352000337	conserved gate region; other site
703352000338	putative PBP binding loops; other site
703352000339	ABC-ATPase subunit interface; other site
703352000340	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
703352000341	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
703352000342	Walker A/P-loop; other site
703352000343	ATP binding site [chemical binding]; other site
703352000344	Q-loop/lid; other site
703352000345	ABC transporter signature motif; other site
703352000346	Walker B; other site
703352000347	D-loop; other site
703352000348	H-loop/switch region; other site
703352000349	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
703352000350	Protein of unknown function (DUF3131); Region: DUF3131; pfam11329
703352000351	Putative glucoamylase; Region: Glycoamylase; pfam10091
703352000352	Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753
703352000353	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
703352000354	First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756
703352000355	Protein of unknown function, DUF608; Region: DUF608; pfam04685
703352000356	Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488
703352000357	nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321
703352000358	active site
703352000359	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
703352000360	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
703352000361	S-adenosylmethionine binding site [chemical binding]; other site
703352000362	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
703352000363	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
703352000364	putative substrate binding site [chemical binding]; other site
703352000365	putative ATP binding site [chemical binding]; other site
703352000366	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
703352000367	classical (c) SDRs; Region: SDR_c; cd05233
703352000368	NAD(P) binding site [chemical binding]; other site
703352000369	active site
703352000370	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
703352000371	Transglycosylase; Region: Transgly; pfam00912
703352000372	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
703352000373	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
703352000374	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
703352000375	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
703352000376	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
703352000377	catalytic site [active]
703352000378	putative active site [active]
703352000379	putative substrate binding site [chemical binding]; other site
703352000380	hypothetical protein; Validated; Region: PRK09104
703352000381	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
703352000382	metal binding site [ion binding]; metal-binding site
703352000383	putative dimer interface [polypeptide binding]; other site
703352000384	DNA polymerase I; Region: pola; TIGR00593
703352000385	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
703352000386	active site
703352000387	metal binding site 1 [ion binding]; metal-binding site
703352000388	putative 5' ssDNA interaction site; other site
703352000389	metal binding site 3; metal-binding site
703352000390	metal binding site 2 [ion binding]; metal-binding site
703352000391	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
703352000392	putative DNA binding site [nucleotide binding]; other site
703352000393	putative metal binding site [ion binding]; other site
703352000394	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
703352000395	active site
703352000396	catalytic site [active]
703352000397	substrate binding site [chemical binding]; other site
703352000398	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
703352000399	active site
703352000400	DNA binding site [nucleotide binding]
703352000401	catalytic site [active]
703352000402	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
703352000403	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
703352000404	putative Mg++ binding site [ion binding]; other site
703352000405	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
703352000406	nucleotide binding region [chemical binding]; other site
703352000407	ATP-binding site [chemical binding]; other site
703352000408	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
703352000409	RNA binding site [nucleotide binding]; other site
703352000410	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
703352000411	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
703352000412	Mg2+ binding site [ion binding]; other site
703352000413	G-X-G motif; other site
703352000414	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
703352000415	anchoring element; other site
703352000416	dimer interface [polypeptide binding]; other site
703352000417	ATP binding site [chemical binding]; other site
703352000418	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
703352000419	active site
703352000420	putative metal-binding site [ion binding]; other site
703352000421	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
703352000422	S-formylglutathione hydrolase; Region: PLN02442
703352000423	S-formylglutathione hydrolase; Region: PLN02442
703352000424	Protein of unknown function (DUF1345); Region: DUF1345; cl01753
703352000425	Protein of unknown function (DUF1345); Region: DUF1345; cl01753
703352000426	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
703352000427	Coenzyme A binding pocket [chemical binding]; other site
703352000428	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
703352000429	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
703352000430	substrate binding site [chemical binding]; other site
703352000431	catalytic Zn binding site [ion binding]; other site
703352000432	NAD binding site [chemical binding]; other site
703352000433	structural Zn binding site [ion binding]; other site
703352000434	dimer interface [polypeptide binding]; other site
703352000435	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
703352000436	putative homodimer interface [polypeptide binding]; other site
703352000437	putative homotetramer interface [polypeptide binding]; other site
703352000438	putative metal binding site [ion binding]; other site
703352000439	putative homodimer-homodimer interface [polypeptide binding]; other site
703352000440	putative allosteric switch controlling residues; other site
703352000441	HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643
703352000442	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
703352000443	ATP binding site [chemical binding]; other site
703352000444	putative Mg++ binding site [ion binding]; other site
703352000445	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
703352000446	nucleotide binding region [chemical binding]; other site
703352000447	ATP-binding site [chemical binding]; other site
703352000448	Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847
703352000449	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
703352000450	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
703352000451	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
703352000452	ATP binding site [chemical binding]; other site
703352000453	Mg2+ binding site [ion binding]; other site
703352000454	G-X-G motif; other site
703352000455	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
703352000456	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
703352000457	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
703352000458	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
703352000459	active site
703352000460	phosphorylation site [posttranslational modification]
703352000461	intermolecular recognition site; other site
703352000462	dimerization interface [polypeptide binding]; other site
703352000463	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
703352000464	Protein of unknown function (DUF1052); Region: DUF1052; pfam06319
703352000465	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
703352000466	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
703352000467	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
703352000468	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
703352000469	Universal stress protein family; Region: Usp; pfam00582
703352000470	Ligand Binding Site [chemical binding]; other site
703352000471	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
703352000472	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
703352000473	active site
703352000474	HIGH motif; other site
703352000475	dimer interface [polypeptide binding]; other site
703352000476	KMSKS motif; other site
703352000477	potential frameshift: common BLAST hit: gi|225851678|ref|YP_002731911.1| integral membrane protein MviN
703352000478	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
703352000479	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
703352000480	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
703352000481	PII uridylyl-transferase; Provisional; Region: PRK05092
703352000482	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
703352000483	metal binding triad; other site
703352000484	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
703352000485	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
703352000486	Zn2+ binding site [ion binding]; other site
703352000487	Mg2+ binding site [ion binding]; other site
703352000488	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
703352000489	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
703352000490	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
703352000491	Malic enzyme, N-terminal domain; Region: malic; pfam00390
703352000492	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
703352000493	putative NAD(P) binding site [chemical binding]; other site
703352000494	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
703352000495	MutS domain I; Region: MutS_I; pfam01624
703352000496	MutS domain II; Region: MutS_II; pfam05188
703352000497	MutS domain III; Region: MutS_III; pfam05192
703352000498	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
703352000499	Walker A/P-loop; other site
703352000500	ATP binding site [chemical binding]; other site
703352000501	Q-loop/lid; other site
703352000502	ABC transporter signature motif; other site
703352000503	Walker B; other site
703352000504	D-loop; other site
703352000505	H-loop/switch region; other site
703352000506	Putative hemolysin [General function prediction only]; Region: COG3176
703352000507	lipoprotein signal peptidase; Provisional; Region: PRK14795
703352000508	lipoprotein signal peptidase; Provisional; Region: PRK14787
703352000509	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
703352000510	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
703352000511	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
703352000512	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
703352000513	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
703352000514	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
703352000515	IHF dimer interface [polypeptide binding]; other site
703352000516	IHF - DNA interface [nucleotide binding]; other site
703352000517	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
703352000518	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
703352000519	tandem repeat interface [polypeptide binding]; other site
703352000520	oligomer interface [polypeptide binding]; other site
703352000521	active site residues [active]
703352000522	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375
703352000523	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
703352000524	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
703352000525	OstA-like protein; Region: OstA; pfam03968
703352000526	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
703352000527	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
703352000528	Walker A/P-loop; other site
703352000529	ATP binding site [chemical binding]; other site
703352000530	Q-loop/lid; other site
703352000531	ABC transporter signature motif; other site
703352000532	Walker B; other site
703352000533	D-loop; other site
703352000534	H-loop/switch region; other site
703352000535	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
703352000536	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
703352000537	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
703352000538	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
703352000539	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
703352000540	30S subunit binding site; other site
703352000541	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
703352000542	active site
703352000543	phosphorylation site [posttranslational modification]
703352000544	Uncharacterized small protein [Function unknown]; Region: COG5568
703352000545	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
703352000546	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
703352000547	putative dimer interface [polypeptide binding]; other site
703352000548	Integral membrane protein [Function unknown]; Region: COG5488
703352000549	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
703352000550	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
703352000551	minor groove reading motif; other site
703352000552	helix-hairpin-helix signature motif; other site
703352000553	substrate binding pocket [chemical binding]; other site
703352000554	active site
703352000555	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
703352000556	Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126
703352000557	CysZ-like protein; Reviewed; Region: PRK12768
703352000558	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
703352000559	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
703352000560	substrate binding site [chemical binding]; other site
703352000561	ATP binding site [chemical binding]; other site
703352000562	UPF0126 domain; Region: UPF0126; pfam03458
703352000563	Predicted membrane protein [Function unknown]; Region: COG2860
703352000564	UPF0126 domain; Region: UPF0126; pfam03458
703352000565	heat shock protein GrpE; Provisional; Region: PRK14141
703352000566	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
703352000567	dimer interface [polypeptide binding]; other site
703352000568	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
703352000569	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
703352000570	ribonuclease PH; Reviewed; Region: rph; PRK00173
703352000571	Ribonuclease PH; Region: RNase_PH_bact; cd11362
703352000572	hexamer interface [polypeptide binding]; other site
703352000573	active site
703352000574	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
703352000575	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
703352000576	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
703352000577	active site
703352000578	dimerization interface [polypeptide binding]; other site
703352000579	coproporphyrinogen III oxidase; Provisional; Region: PRK09057
703352000580	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
703352000581	FeS/SAM binding site; other site
703352000582	HemN C-terminal domain; Region: HemN_C; pfam06969
703352000583	Predicted methyltransferases [General function prediction only]; Region: COG0313
703352000584	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
703352000585	putative SAM binding site [chemical binding]; other site
703352000586	putative homodimer interface [polypeptide binding]; other site
703352000587	hypothetical protein; Reviewed; Region: PRK12497
703352000588	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
703352000589	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
703352000590	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
703352000591	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
703352000592	active site
703352000593	SAM binding site [chemical binding]; other site
703352000594	homodimer interface [polypeptide binding]; other site
703352000595	Protein of unknown function (DUF2849); Region: DUF2849; pfam11011
703352000596	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
703352000597	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
703352000598	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
703352000599	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
703352000600	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
703352000601	Active Sites [active]
703352000602	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3749
703352000603	Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876
703352000604	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
703352000605	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
703352000606	active site
703352000607	DNA binding site [nucleotide binding]
703352000608	BA14K-like protein; Region: BA14K; pfam07886
703352000609	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
703352000610	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
703352000611	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
703352000612	substrate binding pocket [chemical binding]; other site
703352000613	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
703352000614	B12 binding site [chemical binding]; other site
703352000615	cobalt ligand [ion binding]; other site
703352000616	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
703352000617	Autoinducer binding domain; Region: Autoind_bind; pfam03472
703352000618	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
703352000619	DNA binding residues [nucleotide binding]
703352000620	aminotransferase; Provisional; Region: PRK06105
703352000621	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
703352000622	inhibitor-cofactor binding pocket; inhibition site
703352000623	pyridoxal 5'-phosphate binding site [chemical binding]; other site
703352000624	catalytic residue [active]
703352000625	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
703352000626	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
703352000627	Active Sites [active]
703352000628	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
703352000629	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
703352000630	CysD dimerization site [polypeptide binding]; other site
703352000631	G1 box; other site
703352000632	putative GEF interaction site [polypeptide binding]; other site
703352000633	GTP/Mg2+ binding site [chemical binding]; other site
703352000634	Switch I region; other site
703352000635	G2 box; other site
703352000636	G3 box; other site
703352000637	Switch II region; other site
703352000638	G4 box; other site
703352000639	G5 box; other site
703352000640	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
703352000641	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
703352000642	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
703352000643	ligand-binding site [chemical binding]; other site
703352000644	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
703352000645	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
703352000646	active site
703352000647	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
703352000648	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
703352000649	ligand binding site [chemical binding]; other site
703352000650	flexible hinge region; other site
703352000651	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
703352000652	putative switch regulator; other site
703352000653	non-specific DNA interactions [nucleotide binding]; other site
703352000654	DNA binding site [nucleotide binding]
703352000655	sequence specific DNA binding site [nucleotide binding]; other site
703352000656	putative cAMP binding site [chemical binding]; other site
703352000657	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
703352000658	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
703352000659	active site
703352000660	dimerization interface [polypeptide binding]; other site
703352000661	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
703352000662	DNA binding residues [nucleotide binding]
703352000663	dimerization interface [polypeptide binding]; other site
703352000664	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
703352000665	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
703352000666	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
703352000667	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
703352000668	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
703352000669	GAF domain; Region: GAF; pfam01590
703352000670	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
703352000671	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
703352000672	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
703352000673	NAD(P) binding site [chemical binding]; other site
703352000674	catalytic residues [active]
703352000675	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
703352000676	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
703352000677	NAD binding site [chemical binding]; other site
703352000678	substrate binding site [chemical binding]; other site
703352000679	catalytic Zn binding site [ion binding]; other site
703352000680	tetramer interface [polypeptide binding]; other site
703352000681	structural Zn binding site [ion binding]; other site
703352000682	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3564
703352000683	Transcriptional regulators [Transcription]; Region: PurR; COG1609
703352000684	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
703352000685	DNA binding site [nucleotide binding]
703352000686	domain linker motif; other site
703352000687	Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545
703352000688	putative dimerization interface [polypeptide binding]; other site
703352000689	putative ligand binding site [chemical binding]; other site
703352000690	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
703352000691	ABC transporter; Region: ABC_tran; pfam00005
703352000692	Q-loop/lid; other site
703352000693	ABC transporter signature motif; other site
703352000694	Walker B; other site
703352000695	D-loop; other site
703352000696	H-loop/switch region; other site
703352000697	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
703352000698	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
703352000699	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
703352000700	Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097
703352000701	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
703352000702	NAD(P) binding site [chemical binding]; other site
703352000703	catalytic residues [active]
703352000704	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
703352000705	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
703352000706	Putative transcription activator [Transcription]; Region: TenA; COG0819
703352000707	NMT1/THI5 like; Region: NMT1; pfam09084
703352000708	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
703352000709	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
703352000710	active site
703352000711	thiamine phosphate binding site [chemical binding]; other site
703352000712	pyrophosphate binding site [ion binding]; other site
703352000713	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
703352000714	ThiS interaction site; other site
703352000715	putative active site [active]
703352000716	tetramer interface [polypeptide binding]; other site
703352000717	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
703352000718	thiS-thiF/thiG interaction site; other site
703352000719	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
703352000720	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
703352000721	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
703352000722	dimer interface [polypeptide binding]; other site
703352000723	substrate binding site [chemical binding]; other site
703352000724	ATP binding site [chemical binding]; other site
703352000725	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
703352000726	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
703352000727	putative active site [active]
703352000728	heme pocket [chemical binding]; other site
703352000729	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
703352000730	putative active site [active]
703352000731	heme pocket [chemical binding]; other site
703352000732	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
703352000733	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
703352000734	metal binding site [ion binding]; metal-binding site
703352000735	active site
703352000736	I-site; other site
703352000737	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
703352000738	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
703352000739	metal-binding site [ion binding]
703352000740	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
703352000741	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
703352000742	metal-binding site [ion binding]
703352000743	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
703352000744	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
703352000745	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
703352000746	DNA binding residues [nucleotide binding]
703352000747	dimer interface [polypeptide binding]; other site
703352000748	copper binding site [ion binding]; other site
703352000749	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352000750	dimer interface [polypeptide binding]; other site
703352000751	conserved gate region; other site
703352000752	putative PBP binding loops; other site
703352000753	ABC-ATPase subunit interface; other site
703352000754	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
703352000755	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
703352000756	Walker A/P-loop; other site
703352000757	ATP binding site [chemical binding]; other site
703352000758	Q-loop/lid; other site
703352000759	ABC transporter signature motif; other site
703352000760	Walker B; other site
703352000761	D-loop; other site
703352000762	H-loop/switch region; other site
703352000763	CBS domain; Region: CBS; pfam00571
703352000764	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352000765	dimer interface [polypeptide binding]; other site
703352000766	conserved gate region; other site
703352000767	ABC-ATPase subunit interface; other site
703352000768	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
703352000769	nitrobindin heme-binding domain; Region: nitrobindin; cl10502
703352000770	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
703352000771	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
703352000772	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
703352000773	NAD(P) binding site [chemical binding]; other site
703352000774	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
703352000775	hydroxyglutarate oxidase; Provisional; Region: PRK11728
703352000776	Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311
703352000777	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
703352000778	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
703352000779	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
703352000780	Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583
703352000781	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
703352000782	Amidohydrolase; Region: Amidohydro_2; pfam04909
703352000783	active site
703352000784	Transcriptional regulator [Transcription]; Region: IclR; COG1414
703352000785	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
703352000786	putative DNA binding site [nucleotide binding]; other site
703352000787	putative Zn2+ binding site [ion binding]; other site
703352000788	Bacterial transcriptional regulator; Region: IclR; pfam01614
703352000789	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
703352000790	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
703352000791	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352000792	dimer interface [polypeptide binding]; other site
703352000793	conserved gate region; other site
703352000794	putative PBP binding loops; other site
703352000795	ABC-ATPase subunit interface; other site
703352000796	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
703352000797	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352000798	dimer interface [polypeptide binding]; other site
703352000799	conserved gate region; other site
703352000800	putative PBP binding loops; other site
703352000801	ABC-ATPase subunit interface; other site
703352000802	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
703352000803	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
703352000804	Walker A/P-loop; other site
703352000805	ATP binding site [chemical binding]; other site
703352000806	Q-loop/lid; other site
703352000807	ABC transporter signature motif; other site
703352000808	Walker B; other site
703352000809	D-loop; other site
703352000810	H-loop/switch region; other site
703352000811	TOBE domain; Region: TOBE_2; pfam08402
703352000812	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
703352000813	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
703352000814	active site pocket [active]
703352000815	Uncharacterized conserved protein [Function unknown]; Region: COG3254
703352000816	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
703352000817	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
703352000818	human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368
703352000819	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550
703352000820	NAD binding site [chemical binding]; other site
703352000821	homotetramer interface [polypeptide binding]; other site
703352000822	homodimer interface [polypeptide binding]; other site
703352000823	active site
703352000824	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
703352000825	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
703352000826	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
703352000827	Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324
703352000828	putative active site pocket [active]
703352000829	metal binding site [ion binding]; metal-binding site
703352000830	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
703352000831	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
703352000832	active site
703352000833	Int/Topo IB signature motif; other site
703352000834	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
703352000835	Toprim domain; Region: Toprim_3; pfam13362
703352000836	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
703352000837	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
703352000838	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
703352000839	potential frameshift: common BLAST hit: gi|376271828|ref|YP_005150406.1| flagellar protein FlgJ
703352000840	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
703352000841	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
703352000842	non-specific DNA binding site [nucleotide binding]; other site
703352000843	salt bridge; other site
703352000844	sequence-specific DNA binding site [nucleotide binding]; other site
703352000845	TIR domain; Region: TIR_2; pfam13676
703352000846	zinc-binding protein; Provisional; Region: PRK01343
703352000847	Maf-like protein; Region: Maf; pfam02545
703352000848	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
703352000849	active site
703352000850	dimer interface [polypeptide binding]; other site
703352000851	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
703352000852	rRNA binding site [nucleotide binding]; other site
703352000853	predicted 30S ribosome binding site; other site
703352000854	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
703352000855	Low molecular weight phosphatase family; Region: LMWPc; cd00115
703352000856	active site
703352000857	hypothetical protein; Provisional; Region: PRK02853
703352000858	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
703352000859	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
703352000860	NAD binding site [chemical binding]; other site
703352000861	dimerization interface [polypeptide binding]; other site
703352000862	product binding site; other site
703352000863	substrate binding site [chemical binding]; other site
703352000864	zinc binding site [ion binding]; other site
703352000865	catalytic residues [active]
703352000866	Protein of unknown function (DUF2948); Region: DUF2948; pfam11164
703352000867	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
703352000868	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
703352000869	hinge; other site
703352000870	active site
703352000871	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
703352000872	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
703352000873	INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184
703352000874	Int/Topo IB signature motif; other site
703352000875	BRO family, N-terminal domain; Region: Bro-N; smart01040
703352000876	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
703352000877	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
703352000878	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cl00541
703352000879	dimerization interface [polypeptide binding]; other site
703352000880	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
703352000881	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
703352000882	alpha-gamma subunit interface [polypeptide binding]; other site
703352000883	beta-gamma subunit interface [polypeptide binding]; other site
703352000884	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
703352000885	gamma-beta subunit interface [polypeptide binding]; other site
703352000886	alpha-beta subunit interface [polypeptide binding]; other site
703352000887	urease subunit alpha; Reviewed; Region: ureC; PRK13207
703352000888	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
703352000889	subunit interactions [polypeptide binding]; other site
703352000890	active site
703352000891	flap region; other site
703352000892	Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371
703352000893	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
703352000894	dimer interface [polypeptide binding]; other site
703352000895	catalytic residues [active]
703352000896	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
703352000897	UreF; Region: UreF; pfam01730
703352000898	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
703352000899	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
703352000900	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
703352000901	ATP binding site [chemical binding]; other site
703352000902	Mg2+ binding site [ion binding]; other site
703352000903	G-X-G motif; other site
703352000904	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
703352000905	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
703352000906	HlyD family secretion protein; Region: HlyD_3; pfam13437
703352000907	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
703352000908	phenylhydantoinase; Validated; Region: PRK08323
703352000909	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
703352000910	tetramer interface [polypeptide binding]; other site
703352000911	active site
703352000912	allantoate amidohydrolase; Reviewed; Region: PRK12893
703352000913	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
703352000914	active site
703352000915	metal binding site [ion binding]; metal-binding site
703352000916	dimer interface [polypeptide binding]; other site
703352000917	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
703352000918	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
703352000919	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
703352000920	nudix motif; other site
703352000921	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
703352000922	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
703352000923	homodimer interface [polypeptide binding]; other site
703352000924	active site
703352000925	FMN binding site [chemical binding]; other site
703352000926	substrate binding site [chemical binding]; other site
703352000927	4Fe-4S binding domain; Region: Fer4; cl02805
703352000928	4Fe-4S binding domain; Region: Fer4; pfam00037
703352000929	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
703352000930	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
703352000931	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
703352000932	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
703352000933	putative hydrophobic ligand binding site [chemical binding]; other site
703352000934	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
703352000935	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
703352000936	active site
703352000937	dimer interface [polypeptide binding]; other site
703352000938	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
703352000939	dimer interface [polypeptide binding]; other site
703352000940	active site
703352000941	Predicted deacylase [General function prediction only]; Region: COG3608
703352000942	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250
703352000943	active site
703352000944	Zn binding site [ion binding]; other site
703352000945	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
703352000946	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
703352000947	motif II; other site
703352000948	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
703352000949	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
703352000950	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
703352000951	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
703352000952	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
703352000953	acyl-activating enzyme (AAE) consensus motif; other site
703352000954	putative AMP binding site [chemical binding]; other site
703352000955	putative active site [active]
703352000956	putative CoA binding site [chemical binding]; other site
703352000957	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
703352000958	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
703352000959	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
703352000960	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
703352000961	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
703352000962	HlyD family secretion protein; Region: HlyD_3; pfam13437
703352000963	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
703352000964	Protein export membrane protein; Region: SecD_SecF; cl14618
703352000965	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
703352000966	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
703352000967	substrate binding pocket [chemical binding]; other site
703352000968	membrane-bound complex binding site; other site
703352000969	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
703352000970	CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427
703352000971	DXD motif; other site
703352000972	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
703352000973	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
703352000974	dimer interface [polypeptide binding]; other site
703352000975	phosphorylation site [posttranslational modification]
703352000976	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
703352000977	ATP binding site [chemical binding]; other site
703352000978	Mg2+ binding site [ion binding]; other site
703352000979	G-X-G motif; other site
703352000980	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5352
703352000981	acetylornithine transaminase protein; Provisional; Region: argD; PRK01278
703352000982	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
703352000983	inhibitor-cofactor binding pocket; inhibition site
703352000984	pyridoxal 5'-phosphate binding site [chemical binding]; other site
703352000985	catalytic residue [active]
703352000986	ornithine carbamoyltransferase; Provisional; Region: PRK00779
703352000987	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
703352000988	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
703352000989	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
703352000990	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
703352000991	dimerization interface [polypeptide binding]; other site
703352000992	domain crossover interface; other site
703352000993	redox-dependent activation switch; other site
703352000994	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
703352000995	O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504
703352000996	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
703352000997	homodimer interface [polypeptide binding]; other site
703352000998	substrate-cofactor binding pocket; other site
703352000999	pyridoxal 5'-phosphate binding site [chemical binding]; other site
703352001000	catalytic residue [active]
703352001001	2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559
703352001002	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
703352001003	trimer interface [polypeptide binding]; other site
703352001004	active site
703352001005	Deoxycytidine deaminase [Nucleotide transport and metabolism]; Region: Dcd; COG0717
703352001006	trimer interface [polypeptide binding]; other site
703352001007	active site
703352001008	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
703352001009	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
703352001010	conserved cys residue [active]
703352001011	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
703352001012	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
703352001013	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
703352001014	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
703352001015	potential frameshift: common BLAST hit: gi|225851857|ref|YP_002732090.1| dihydroorotate dehydrogenase 2
703352001016	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
703352001017	phosphate binding site [ion binding]; other site
703352001018	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
703352001019	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
703352001020	quinone interaction residues [chemical binding]; other site
703352001021	active site
703352001022	catalytic residues [active]
703352001023	FMN binding site [chemical binding]; other site
703352001024	substrate binding site [chemical binding]; other site
703352001025	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502
703352001026	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
703352001027	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
703352001028	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
703352001029	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
703352001030	active site
703352001031	phosphorylation site [posttranslational modification]
703352001032	intermolecular recognition site; other site
703352001033	dimerization interface [polypeptide binding]; other site
703352001034	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
703352001035	DNA binding residues [nucleotide binding]
703352001036	dimerization interface [polypeptide binding]; other site
703352001037	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
703352001038	Na binding site [ion binding]; other site
703352001039	PAS fold; Region: PAS_7; pfam12860
703352001040	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
703352001041	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
703352001042	dimer interface [polypeptide binding]; other site
703352001043	phosphorylation site [posttranslational modification]
703352001044	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
703352001045	ATP binding site [chemical binding]; other site
703352001046	Mg2+ binding site [ion binding]; other site
703352001047	G-X-G motif; other site
703352001048	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
703352001049	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
703352001050	active site
703352001051	phosphorylation site [posttranslational modification]
703352001052	intermolecular recognition site; other site
703352001053	dimerization interface [polypeptide binding]; other site
703352001054	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
703352001055	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
703352001056	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
703352001057	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
703352001058	substrate-cofactor binding pocket; other site
703352001059	pyridoxal 5'-phosphate binding site [chemical binding]; other site
703352001060	catalytic residue [active]
703352001061	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
703352001062	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
703352001063	putative active site [active]
703352001064	putative metal binding site [ion binding]; other site
703352001065	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
703352001066	2-oxoacid ferredoxin oxidoreductase; Provisional; Region: PRK13030
703352001067	Glycosyltransferase family 29 (sialyltransferase); Region: Glyco_transf_29; pfam00777
703352001068	Transcriptional regulator [Transcription]; Region: LysR; COG0583
703352001069	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
703352001070	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
703352001071	putative dimerization interface [polypeptide binding]; other site
703352001072	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
703352001073	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
703352001074	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782
703352001075	pantoate--beta-alanine ligase; Region: panC; TIGR00018
703352001076	Pantoate-beta-alanine ligase; Region: PanC; cd00560
703352001077	active site
703352001078	ATP-binding site [chemical binding]; other site
703352001079	pantoate-binding site; other site
703352001080	HXXH motif; other site
703352001081	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
703352001082	active site
703352001083	oligomerization interface [polypeptide binding]; other site
703352001084	metal binding site [ion binding]; metal-binding site
703352001085	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
703352001086	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
703352001087	FAD binding pocket [chemical binding]; other site
703352001088	FAD binding motif [chemical binding]; other site
703352001089	phosphate binding motif [ion binding]; other site
703352001090	beta-alpha-beta structure motif; other site
703352001091	NAD binding pocket [chemical binding]; other site
703352001092	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
703352001093	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
703352001094	dimer interface [polypeptide binding]; other site
703352001095	active site
703352001096	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
703352001097	catalytic residues [active]
703352001098	substrate binding site [chemical binding]; other site
703352001099	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
703352001100	Proline racemase [Amino acid transport and metabolism]; Region: COG3938
703352001101	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
703352001102	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
703352001103	multidrug efflux protein; Reviewed; Region: PRK01766
703352001104	cation binding site [ion binding]; other site
703352001105	Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342
703352001106	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564
703352001107	Cache domain; Region: Cache_2; pfam08269
703352001108	Histidine kinase; Region: HisKA_3; pfam07730
703352001109	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
703352001110	ATP binding site [chemical binding]; other site
703352001111	Mg2+ binding site [ion binding]; other site
703352001112	G-X-G motif; other site
703352001113	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
703352001114	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
703352001115	active site
703352001116	phosphorylation site [posttranslational modification]
703352001117	intermolecular recognition site; other site
703352001118	dimerization interface [polypeptide binding]; other site
703352001119	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
703352001120	DNA binding residues [nucleotide binding]
703352001121	dimerization interface [polypeptide binding]; other site
703352001122	TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665
703352001123	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
703352001124	DctM-like transporters; Region: DctM; pfam06808
703352001125	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
703352001126	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
703352001127	hypothetical protein; Provisional; Region: PRK11171
703352001128	Protein of unknown function (DUF861); Region: Cupin_3; pfam05899
703352001129	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
703352001130	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
703352001131	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
703352001132	active site
703352001133	catalytic site [active]
703352001134	tetramer interface [polypeptide binding]; other site
703352001135	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195
703352001136	Transthyretin_like.  This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase).  TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl17222
703352001137	homotetramer interface [polypeptide binding]; other site
703352001138	active site
703352001139	Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [Nucleotide transport and metabolism]; Region: XdhA; COG4630
703352001140	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
703352001141	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
703352001142	Xanthine dehydrogenase, molybdopterin-binding subunit B [Nucleotide transport and metabolism]; Region: XdhB; COG4631
703352001143	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
703352001144	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
703352001145	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
703352001146	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
703352001147	XdhC Rossmann domain; Region: XdhC_C; pfam13478
703352001148	Transcriptional regulator [Transcription]; Region: LysR; COG0583
703352001149	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
703352001150	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
703352001151	putative effector binding pocket; other site
703352001152	dimerization interface [polypeptide binding]; other site
703352001153	Predicted membrane protein [Function unknown]; Region: COG3748
703352001154	Protein of unknown function (DUF989); Region: DUF989; pfam06181
703352001155	Cytochrome c; Region: Cytochrom_C; pfam00034
703352001156	guanine deaminase; Provisional; Region: PRK09228
703352001157	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
703352001158	active site
703352001159	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
703352001160	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
703352001161	MOFRL family; Region: MOFRL; pfam05161
703352001162	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597
703352001163	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
703352001164	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
703352001165	metal-binding site [ion binding]
703352001166	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
703352001167	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
703352001168	motif II; other site
703352001169	Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456
703352001170	FixH; Region: FixH; pfam05751
703352001171	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
703352001172	4Fe-4S binding domain; Region: Fer4_5; pfam12801
703352001173	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
703352001174	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
703352001175	Cytochrome c; Region: Cytochrom_C; pfam00034
703352001176	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
703352001177	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324
703352001178	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
703352001179	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433
703352001180	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
703352001181	Low-spin heme binding site [chemical binding]; other site
703352001182	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
703352001183	Putative water exit pathway; other site
703352001184	Binuclear center (active site) [active]
703352001185	Putative proton exit pathway; other site
703352001186	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
703352001187	metal binding site 2 [ion binding]; metal-binding site
703352001188	putative DNA binding helix; other site
703352001189	metal binding site 1 [ion binding]; metal-binding site
703352001190	dimer interface [polypeptide binding]; other site
703352001191	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
703352001192	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
703352001193	catalytic residues [active]
703352001194	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
703352001195	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
703352001196	NAD(P) binding site [chemical binding]; other site
703352001197	catalytic residues [active]
703352001198	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
703352001199	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
703352001200	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
703352001201	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
703352001202	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
703352001203	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
703352001204	DNA binding site [nucleotide binding]
703352001205	active site
703352001206	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
703352001207	ArsC family; Region: ArsC; pfam03960
703352001208	putative catalytic residues [active]
703352001209	Predicted membrane protein [Function unknown]; Region: COG4129
703352001210	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
703352001211	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
703352001212	putative substrate translocation pore; other site
703352001213	D-galactonate transporter; Region: 2A0114; TIGR00893
703352001214	microcin B17 transporter; Reviewed; Region: PRK11098
703352001215	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649
703352001216	GTP-binding protein Der; Reviewed; Region: PRK00093
703352001217	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
703352001218	G1 box; other site
703352001219	GTP/Mg2+ binding site [chemical binding]; other site
703352001220	Switch I region; other site
703352001221	G2 box; other site
703352001222	Switch II region; other site
703352001223	G3 box; other site
703352001224	G4 box; other site
703352001225	G5 box; other site
703352001226	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
703352001227	G1 box; other site
703352001228	GTP/Mg2+ binding site [chemical binding]; other site
703352001229	Switch I region; other site
703352001230	G2 box; other site
703352001231	G3 box; other site
703352001232	Switch II region; other site
703352001233	G4 box; other site
703352001234	G5 box; other site
703352001235	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
703352001236	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
703352001237	nucleotide binding site [chemical binding]; other site
703352001238	putative NEF/HSP70 interaction site [polypeptide binding]; other site
703352001239	SBD interface [polypeptide binding]; other site
703352001240	Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773
703352001241	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
703352001242	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5336
703352001243	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
703352001244	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
703352001245	F0F1 ATP synthase subunit C; Validated; Region: PRK07558
703352001246	F0F1 ATP synthase subunit B'; Validated; Region: PRK09174
703352001247	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
703352001248	F0F1 ATP synthase subunit B; Validated; Region: PRK09173
703352001249	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
703352001250	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
703352001251	RNA/DNA hybrid binding site [nucleotide binding]; other site
703352001252	active site
703352001253	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
703352001254	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
703352001255	FeS/SAM binding site; other site
703352001256	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
703352001257	active site
703352001258	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608
703352001259	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
703352001260	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560
703352001261	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
703352001262	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
703352001263	tandem repeat interface [polypeptide binding]; other site
703352001264	oligomer interface [polypeptide binding]; other site
703352001265	active site residues [active]
703352001266	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
703352001267	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
703352001268	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
703352001269	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
703352001270	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
703352001271	substrate binding pocket [chemical binding]; other site
703352001272	chain length determination region; other site
703352001273	substrate-Mg2+ binding site; other site
703352001274	catalytic residues [active]
703352001275	aspartate-rich region 1; other site
703352001276	active site lid residues [active]
703352001277	aspartate-rich region 2; other site
703352001278	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
703352001279	binding surface
703352001280	TPR motif; other site
703352001281	TPR repeat; Region: TPR_11; pfam13414
703352001282	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
703352001283	binding surface
703352001284	TPR motif; other site
703352001285	TPR repeat; Region: TPR_11; pfam13414
703352001286	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
703352001287	binding surface
703352001288	TPR motif; other site
703352001289	TPR repeat; Region: TPR_11; pfam13414
703352001290	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
703352001291	dimer interface [polypeptide binding]; other site
703352001292	motif 1; other site
703352001293	active site
703352001294	motif 2; other site
703352001295	motif 3; other site
703352001296	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
703352001297	DALR anticodon binding domain; Region: DALR_1; pfam05746
703352001298	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
703352001299	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
703352001300	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
703352001301	FAD binding domain; Region: FAD_binding_4; pfam01565
703352001302	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
703352001303	enoyl-CoA hydratase; Provisional; Region: PRK06688
703352001304	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
703352001305	substrate binding site [chemical binding]; other site
703352001306	oxyanion hole (OAH) forming residues; other site
703352001307	trimer interface [polypeptide binding]; other site
703352001308	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
703352001309	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
703352001310	active site
703352001311	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
703352001312	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
703352001313	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
703352001314	metal binding site [ion binding]; metal-binding site
703352001315	active site
703352001316	I-site; other site
703352001317	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
703352001318	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
703352001319	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
703352001320	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
703352001321	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878
703352001322	UbiA prenyltransferase family; Region: UbiA; pfam01040
703352001323	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
703352001324	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
703352001325	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
703352001326	chaperone protein DnaJ; Provisional; Region: PRK14299
703352001327	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
703352001328	HSP70 interaction site [polypeptide binding]; other site
703352001329	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
703352001330	dimer interface [polypeptide binding]; other site
703352001331	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159
703352001332	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
703352001333	NAD binding site [chemical binding]; other site
703352001334	homotetramer interface [polypeptide binding]; other site
703352001335	homodimer interface [polypeptide binding]; other site
703352001336	substrate binding site [chemical binding]; other site
703352001337	active site
703352001338	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
703352001339	catalytic core [active]
703352001340	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
703352001341	DNA-binding site [nucleotide binding]; DNA binding site
703352001342	RNA-binding motif; other site
703352001343	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
703352001344	putative acyl-acceptor binding pocket; other site
703352001345	Protein of unknown function (DUF1344); Region: DUF1344; pfam07076
703352001346	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
703352001347	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
703352001348	Tetramer interface [polypeptide binding]; other site
703352001349	active site
703352001350	FMN-binding site [chemical binding]; other site
703352001351	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
703352001352	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
703352001353	GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807
703352001354	dimerization interface [polypeptide binding]; other site
703352001355	active site
703352001356	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
703352001357	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
703352001358	putative active site [active]
703352001359	Zn binding site [ion binding]; other site
703352001360	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
703352001361	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
703352001362	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
703352001363	Predicted membrane protein [Function unknown]; Region: COG2261
703352001364	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3753
703352001365	Pirin-related protein [General function prediction only]; Region: COG1741
703352001366	Pirin; Region: Pirin; pfam02678
703352001367	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
703352001368	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
703352001369	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
703352001370	TPP-binding site; other site
703352001371	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
703352001372	PYR/PP interface [polypeptide binding]; other site
703352001373	dimer interface [polypeptide binding]; other site
703352001374	TPP binding site [chemical binding]; other site
703352001375	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
703352001376	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
703352001377	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
703352001378	RNA binding surface [nucleotide binding]; other site
703352001379	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
703352001380	S-adenosylmethionine binding site [chemical binding]; other site
703352001381	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
703352001382	Methyltransferase domain; Region: Methyltransf_26; pfam13659
703352001383	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
703352001384	Predicted periplasmic protein [General function prediction only]; Region: COG3895
703352001385	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
703352001386	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
703352001387	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
703352001388	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
703352001389	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
703352001390	ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253
703352001391	Walker A/P-loop; other site
703352001392	ATP binding site [chemical binding]; other site
703352001393	Q-loop/lid; other site
703352001394	ABC transporter signature motif; other site
703352001395	Walker B; other site
703352001396	D-loop; other site
703352001397	H-loop/switch region; other site
703352001398	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
703352001399	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
703352001400	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
703352001401	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
703352001402	classical (c) SDRs; Region: SDR_c; cd05233
703352001403	NAD(P) binding site [chemical binding]; other site
703352001404	active site
703352001405	amidophosphoribosyltransferase; Provisional; Region: PRK09123
703352001406	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
703352001407	active site
703352001408	tetramer interface [polypeptide binding]; other site
703352001409	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
703352001410	active site
703352001411	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
703352001412	Colicin V production protein; Region: Colicin_V; pfam02674
703352001413	DNA repair protein RadA; Provisional; Region: PRK11823
703352001414	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
703352001415	Walker A motif/ATP binding site; other site
703352001416	ATP binding site [chemical binding]; other site
703352001417	Walker B motif; other site
703352001418	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
703352001419	replicative DNA helicase; Provisional; Region: PRK09165
703352001420	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
703352001421	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
703352001422	Walker A motif; other site
703352001423	ATP binding site [chemical binding]; other site
703352001424	Walker B motif; other site
703352001425	DNA binding loops [nucleotide binding]
703352001426	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
703352001427	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
703352001428	S-adenosylmethionine binding site [chemical binding]; other site
703352001429	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
703352001430	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
703352001431	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
703352001432	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
703352001433	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
703352001434	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
703352001435	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
703352001436	3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936
703352001437	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
703352001438	NAD(P) binding site [chemical binding]; other site
703352001439	homotetramer interface [polypeptide binding]; other site
703352001440	homodimer interface [polypeptide binding]; other site
703352001441	active site
703352001442	acyl carrier protein; Provisional; Region: acpP; PRK00982
703352001443	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
703352001444	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
703352001445	dimer interface [polypeptide binding]; other site
703352001446	active site
703352001447	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
703352001448	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
703352001449	dimerization interface [polypeptide binding]; other site
703352001450	Uncharacterized stress-induced protein [Function unknown]; Region: COG1561
703352001451	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
703352001452	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
703352001453	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
703352001454	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
703352001455	catalytic site [active]
703352001456	G-X2-G-X-G-K; other site
703352001457	protease TldD; Provisional; Region: tldD; PRK10735
703352001458	Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342
703352001459	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
703352001460	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
703352001461	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
703352001462	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
703352001463	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
703352001464	Subunit I/III interface [polypeptide binding]; other site
703352001465	D-pathway; other site
703352001466	Subunit I/VIIc interface [polypeptide binding]; other site
703352001467	Subunit I/IV interface [polypeptide binding]; other site
703352001468	Subunit I/II interface [polypeptide binding]; other site
703352001469	Low-spin heme (heme a) binding site [chemical binding]; other site
703352001470	Subunit I/VIIa interface [polypeptide binding]; other site
703352001471	Subunit I/VIa interface [polypeptide binding]; other site
703352001472	Dimer interface; other site
703352001473	Putative water exit pathway; other site
703352001474	Binuclear center (heme a3/CuB) [ion binding]; other site
703352001475	K-pathway; other site
703352001476	Subunit I/Vb interface [polypeptide binding]; other site
703352001477	Putative proton exit pathway; other site
703352001478	Subunit I/VIb interface; other site
703352001479	Subunit I/VIc interface [polypeptide binding]; other site
703352001480	Electron transfer pathway; other site
703352001481	Subunit I/VIIIb interface [polypeptide binding]; other site
703352001482	Subunit I/VIIb interface [polypeptide binding]; other site
703352001483	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
703352001484	UbiA prenyltransferase family; Region: UbiA; pfam01040
703352001485	Cytochrome oxidase assembly factor [Posttranslational modification, protein turnover, chaperones]; Region: COX11; COG3175
703352001486	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
703352001487	Subunit III/VIIa interface [polypeptide binding]; other site
703352001488	Phospholipid binding site [chemical binding]; other site
703352001489	Subunit I/III interface [polypeptide binding]; other site
703352001490	Subunit III/VIb interface [polypeptide binding]; other site
703352001491	Subunit III/VIa interface; other site
703352001492	Subunit III/Vb interface [polypeptide binding]; other site
703352001493	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349
703352001494	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
703352001495	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
703352001496	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
703352001497	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
703352001498	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
703352001499	putative active site [active]
703352001500	putative substrate binding site [chemical binding]; other site
703352001501	ATP binding site [chemical binding]; other site
703352001502	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
703352001503	RNA/DNA hybrid binding site [nucleotide binding]; other site
703352001504	active site
703352001505	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
703352001506	catalytic triad [active]
703352001507	dimer interface [polypeptide binding]; other site
703352001508	Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233
703352001509	hypothetical protein; Validated; Region: PRK00228
703352001510	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
703352001511	PAS fold; Region: PAS_3; pfam08447
703352001512	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
703352001513	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
703352001514	metal binding site [ion binding]; metal-binding site
703352001515	active site
703352001516	I-site; other site
703352001517	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
703352001518	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
703352001519	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
703352001520	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
703352001521	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
703352001522	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
703352001523	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
703352001524	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
703352001525	pyridoxal 5'-phosphate binding site [chemical binding]; other site
703352001526	catalytic residue [active]
703352001527	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
703352001528	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
703352001529	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
703352001530	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
703352001531	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
703352001532	active site
703352001533	motif I; other site
703352001534	motif II; other site
703352001535	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
703352001536	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
703352001537	Cl- selectivity filter; other site
703352001538	Cl- binding residues [ion binding]; other site
703352001539	pore gating glutamate residue; other site
703352001540	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
703352001541	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
703352001542	DNA methylase; Region: N6_N4_Mtase; pfam01555
703352001543	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
703352001544	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
703352001545	motif II; other site
703352001546	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
703352001547	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
703352001548	minor groove reading motif; other site
703352001549	helix-hairpin-helix signature motif; other site
703352001550	substrate binding pocket [chemical binding]; other site
703352001551	active site
703352001552	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
703352001553	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
703352001554	DNA binding and oxoG recognition site [nucleotide binding]
703352001555	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5389
703352001556	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
703352001557	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
703352001558	catalytic residues [active]
703352001559	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
703352001560	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
703352001561	Walker A/P-loop; other site
703352001562	ATP binding site [chemical binding]; other site
703352001563	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
703352001564	ABC transporter signature motif; other site
703352001565	Walker B; other site
703352001566	D-loop; other site
703352001567	H-loop/switch region; other site
703352001568	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
703352001569	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
703352001570	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
703352001571	pyruvate phosphate dikinase; Provisional; Region: PRK09279
703352001572	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
703352001573	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
703352001574	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
703352001575	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
703352001576	Putative catalytic NodB homology domain of uncharacterized BH0857 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH0857_like; cd10955
703352001577	NodB motif; other site
703352001578	putative active site [active]
703352001579	putative catalytic site [active]
703352001580	Protein of unknown function (DUF1499); Region: DUF1499; pfam07386
703352001581	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
703352001582	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
703352001583	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
703352001584	ureidoglycolate hydrolase; Provisional; Region: PRK03606
703352001585	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
703352001586	active site
703352001587	homotetramer interface [polypeptide binding]; other site
703352001588	Protein of unknown function (DUF2793); Region: DUF2793; pfam10983
703352001589	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
703352001590	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
703352001591	NAD(P) binding site [chemical binding]; other site
703352001592	homodimer interface [polypeptide binding]; other site
703352001593	substrate binding site [chemical binding]; other site
703352001594	active site
703352001595	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
703352001596	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
703352001597	Mg++ binding site [ion binding]; other site
703352001598	putative catalytic motif [active]
703352001599	putative substrate binding site [chemical binding]; other site
703352001600	Homeodomain-like domain; Region: HTH_23; cl17451
703352001601	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
703352001602	Integrase core domain; Region: rve_3; pfam13683
703352001603	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
703352001604	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
703352001605	Integrase core domain; Region: rve; pfam00665
703352001606	Formyltransferase, catalytic core domain; Region: FMT_core; cd08369
703352001607	catalytic site [active]
703352001608	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
703352001609	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
703352001610	inhibitor-cofactor binding pocket; inhibition site
703352001611	pyridoxal 5'-phosphate binding site [chemical binding]; other site
703352001612	catalytic residue [active]
703352001613	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
703352001614	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
703352001615	NADP-binding site; other site
703352001616	homotetramer interface [polypeptide binding]; other site
703352001617	substrate binding site [chemical binding]; other site
703352001618	homodimer interface [polypeptide binding]; other site
703352001619	active site
703352001620	Integrase core domain; Region: rve; pfam00665
703352001621	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
703352001622	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
703352001623	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
703352001624	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
703352001625	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
703352001626	Integrase core domain; Region: rve; pfam00665
703352001627	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
703352001628	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
703352001629	Integrase core domain; Region: rve_3; cl15866
703352001630	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
703352001631	ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088
703352001632	active site
703352001633	substrate binding site [chemical binding]; other site
703352001634	metal binding site [ion binding]; metal-binding site
703352001635	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
703352001636	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
703352001637	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
703352001638	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249
703352001639	dimerization interface [polypeptide binding]; other site
703352001640	putative active cleft [active]
703352001641	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
703352001642	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795
703352001643	putative ADP-binding pocket [chemical binding]; other site
703352001644	potential frameshift: common BLAST hit: gi|256368984|ref|YP_003106490.1| ribose ABC transporter, ATP-binding protein
703352001645	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
703352001646	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
703352001647	Walker A/P-loop; other site
703352001648	ATP binding site [chemical binding]; other site
703352001649	Q-loop/lid; other site
703352001650	ABC transporter signature motif; other site
703352001651	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
703352001652	Q-loop/lid; other site
703352001653	ABC transporter signature motif; other site
703352001654	Walker B; other site
703352001655	D-loop; other site
703352001656	H-loop/switch region; other site
703352001657	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
703352001658	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
703352001659	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
703352001660	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
703352001661	TM-ABC transporter signature motif; other site
703352001662	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
703352001663	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_3; cd06311
703352001664	putative ligand binding site [chemical binding]; other site
703352001665	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
703352001666	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
703352001667	Metal-binding active site; metal-binding site
703352001668	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
703352001669	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
703352001670	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
703352001671	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
703352001672	xylose isomerase; Provisional; Region: PRK05474
703352001673	xylose isomerase; Region: xylose_isom_A; TIGR02630
703352001674	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
703352001675	N- and C-terminal domain interface [polypeptide binding]; other site
703352001676	D-xylulose kinase; Region: XylB; TIGR01312
703352001677	active site
703352001678	MgATP binding site [chemical binding]; other site
703352001679	catalytic site [active]
703352001680	metal binding site [ion binding]; metal-binding site
703352001681	xylulose binding site [chemical binding]; other site
703352001682	homodimer interface [polypeptide binding]; other site
703352001683	Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
703352001684	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
703352001685	putative ligand binding site [chemical binding]; other site
703352001686	Helix-turn-helix domain; Region: HTH_18; pfam12833
703352001687	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
703352001688	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
703352001689	betaine aldehyde dehydrogenase; Provisional; Region: PRK13252
703352001690	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
703352001691	NAD(P) binding site [chemical binding]; other site
703352001692	catalytic residues [active]
703352001693	potential frameshift: common BLAST hit: gi|17987663|ref|NP_540297.1| choline dehydrogenase
703352001694	choline dehydrogenase; Validated; Region: PRK02106
703352001695	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
703352001696	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
703352001697	transcriptional regulator BetI; Validated; Region: PRK00767
703352001698	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
703352001699	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
703352001700	L-asparaginase II [Amino acid transport and metabolism]; Region: AnsA; COG4448
703352001701	transcription elongation factor regulatory protein; Validated; Region: PRK06342
703352001702	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
703352001703	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
703352001704	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
703352001705	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
703352001706	uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837
703352001707	Cl binding site [ion binding]; other site
703352001708	oligomer interface [polypeptide binding]; other site
703352001709	Transcriptional regulators [Transcription]; Region: FadR; COG2186
703352001710	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
703352001711	DNA-binding site [nucleotide binding]; DNA binding site
703352001712	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
703352001713	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
703352001714	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
703352001715	putative substrate translocation pore; other site
703352001716	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
703352001717	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
703352001718	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
703352001719	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
703352001720	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
703352001721	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
703352001722	motif II; other site
703352001723	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
703352001724	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
703352001725	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
703352001726	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
703352001727	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
703352001728	Predicted transcriptional regulator [Transcription]; Region: COG4957
703352001729	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
703352001730	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
703352001731	DnaA box-binding interface [nucleotide binding]; other site
703352001732	amidase; Validated; Region: PRK05962
703352001733	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
703352001734	Flavin Reductases; Region: FlaRed; cl00801
703352001735	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
703352001736	putative active site [active]
703352001737	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
703352001738	heme pocket [chemical binding]; other site
703352001739	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
703352001740	dimer interface [polypeptide binding]; other site
703352001741	phosphorylation site [posttranslational modification]
703352001742	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
703352001743	ATP binding site [chemical binding]; other site
703352001744	Mg2+ binding site [ion binding]; other site
703352001745	G-X-G motif; other site
703352001746	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
703352001747	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
703352001748	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
703352001749	Uncharacterized conserved protein [Function unknown]; Region: COG5447
703352001750	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330
703352001751	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
703352001752	Predicted integral membrane protein [Function unknown]; Region: COG5436
703352001753	Uncharacterized conserved protein [Function unknown]; Region: COG5402
703352001754	Transglycosylase; Region: Transgly; pfam00912
703352001755	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
703352001756	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
703352001757	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
703352001758	Uncharacterized conserved protein [Function unknown]; Region: COG5323
703352001759	Terminase-like family; Region: Terminase_6; pfam03237
703352001760	Phage-related protein [Function unknown]; Region: COG4695
703352001761	phage portal protein, HK97 family; Region: portal_HK97; TIGR01537
703352001762	potential frameshift: common BLAST hit: gi|376274659|ref|YP_005115098.1| HK97 family phage prohead protease
703352001763	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
703352001764	potential frameshift: common BLAST hit: gi|376274659|ref|YP_005115098.1| HK97 family phage prohead protease
703352001765	Caudovirus prohead protease; Region: Peptidase_U35; cl01521
703352001766	Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653
703352001767	Phage capsid family; Region: Phage_capsid; pfam05065
703352001768	phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215
703352001769	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
703352001770	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
703352001771	oligomerization interface [polypeptide binding]; other site
703352001772	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
703352001773	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
703352001774	Predicted secreted protein [Function unknown]; Region: COG5437
703352001775	Protein of unknown function (DUF3356); Region: DUF3356; pfam11836
703352001776	Phage-related minor tail protein [Function unknown]; Region: COG5281
703352001777	TIGR02217 family protein; Region: chp_TIGR02217
703352001778	Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931
703352001779	phage conserved hypothetical protein BR0599; Region: phg_TIGR02218
703352001780	Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356
703352001781	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
703352001782	putative phage cell wall peptidase, NlpC/P60 family; Region: phage_NlpC_fam; TIGR02219
703352001783	GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547
703352001784	Putative phage tail protein; Region: Phage-tail_3; pfam13550
703352001785	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
703352001786	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
703352001787	active site
703352001788	phosphorylation site [posttranslational modification]
703352001789	intermolecular recognition site; other site
703352001790	dimerization interface [polypeptide binding]; other site
703352001791	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
703352001792	DNA binding site [nucleotide binding]
703352001793	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
703352001794	HAMP domain; Region: HAMP; pfam00672
703352001795	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
703352001796	ATP binding site [chemical binding]; other site
703352001797	Mg2+ binding site [ion binding]; other site
703352001798	G-X-G motif; other site
703352001799	Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520
703352001800	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
703352001801	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
703352001802	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
703352001803	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
703352001804	Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088
703352001805	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
703352001806	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
703352001807	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
703352001808	protein binding site [polypeptide binding]; other site
703352001809	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
703352001810	protein binding site [polypeptide binding]; other site
703352001811	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
703352001812	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
703352001813	active site
703352001814	phosphorylation site [posttranslational modification]
703352001815	intermolecular recognition site; other site
703352001816	dimerization interface [polypeptide binding]; other site
703352001817	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
703352001818	DNA binding site [nucleotide binding]
703352001819	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
703352001820	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
703352001821	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
703352001822	dimerization interface [polypeptide binding]; other site
703352001823	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
703352001824	dimer interface [polypeptide binding]; other site
703352001825	phosphorylation site [posttranslational modification]
703352001826	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
703352001827	ATP binding site [chemical binding]; other site
703352001828	Mg2+ binding site [ion binding]; other site
703352001829	G-X-G motif; other site
703352001830	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108
703352001831	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
703352001832	metal binding triad; other site
703352001833	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
703352001834	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
703352001835	metal binding triad; other site
703352001836	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
703352001837	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
703352001838	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298
703352001839	O-Antigen ligase; Region: Wzy_C; pfam04932
703352001840	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
703352001841	PAS fold; Region: PAS_3; pfam08447
703352001842	putative active site [active]
703352001843	heme pocket [chemical binding]; other site
703352001844	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
703352001845	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
703352001846	dimer interface [polypeptide binding]; other site
703352001847	phosphorylation site [posttranslational modification]
703352001848	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
703352001849	ATP binding site [chemical binding]; other site
703352001850	Mg2+ binding site [ion binding]; other site
703352001851	G-X-G motif; other site
703352001852	aminopeptidase N; Provisional; Region: pepN; PRK14015
703352001853	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
703352001854	active site
703352001855	Zn binding site [ion binding]; other site
703352001856	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
703352001857	EamA-like transporter family; Region: EamA; pfam00892
703352001858	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
703352001859	Major Facilitator Superfamily; Region: MFS_1; pfam07690
703352001860	putative substrate translocation pore; other site
703352001861	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
703352001862	Fe-S cluster binding site [ion binding]; other site
703352001863	active site
703352001864	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
703352001865	hydroxyglutarate oxidase; Provisional; Region: PRK11728
703352001866	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
703352001867	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3021
703352001868	putative catalytic site [active]
703352001869	putative metal binding site [ion binding]; other site
703352001870	putative phosphate binding site [ion binding]; other site
703352001871	AMP nucleosidase; Provisional; Region: PRK08292
703352001872	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
703352001873	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
703352001874	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
703352001875	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
703352001876	C-terminal domain interface [polypeptide binding]; other site
703352001877	GSH binding site (G-site) [chemical binding]; other site
703352001878	dimer interface [polypeptide binding]; other site
703352001879	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
703352001880	N-terminal domain interface [polypeptide binding]; other site
703352001881	putative dimer interface [polypeptide binding]; other site
703352001882	active site
703352001883	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4731
703352001884	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
703352001885	Uncharacterized conserved protein [Function unknown]; Region: COG1284
703352001886	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
703352001887	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
703352001888	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
703352001889	histidinol-phosphate aminotransferase; Provisional; Region: PRK08153
703352001890	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
703352001891	pyridoxal 5'-phosphate binding site [chemical binding]; other site
703352001892	homodimer interface [polypeptide binding]; other site
703352001893	catalytic residue [active]
703352001894	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
703352001895	active site
703352001896	DNA binding site [nucleotide binding]
703352001897	Int/Topo IB signature motif; other site
703352001898	Porin subfamily; Region: Porin_2; pfam02530
703352001899	Porin subfamily; Region: Porin_2; pfam02530
703352001900	Uncharacterized conserved protein [Function unknown]; Region: COG3743
703352001901	potential frameshift: common BLAST hit: gi|225852166|ref|YP_002732399.1| lytic transglycosylase
703352001902	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
703352001903	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
703352001904	N-acetyl-D-glucosamine binding site [chemical binding]; other site
703352001905	catalytic residue [active]
703352001906	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
703352001907	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
703352001908	dimer interface [polypeptide binding]; other site
703352001909	active site
703352001910	catalytic residue [active]
703352001911	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
703352001912	SmpB-tmRNA interface; other site
703352001913	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
703352001914	Fe-S cluster binding site [ion binding]; other site
703352001915	DNA binding site [nucleotide binding]
703352001916	active site
703352001917	Uncharacterized conserved protein [Function unknown]; Region: COG1432
703352001918	LabA_like proteins; Region: LabA; cd10911
703352001919	putative metal binding site [ion binding]; other site
703352001920	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
703352001921	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
703352001922	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
703352001923	Zn2+ binding site [ion binding]; other site
703352001924	Mg2+ binding site [ion binding]; other site
703352001925	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
703352001926	synthetase active site [active]
703352001927	NTP binding site [chemical binding]; other site
703352001928	metal binding site [ion binding]; metal-binding site
703352001929	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
703352001930	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
703352001931	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
703352001932	active site
703352001933	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
703352001934	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
703352001935	ligand binding site [chemical binding]; other site
703352001936	flexible hinge region; other site
703352001937	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
703352001938	putative switch regulator; other site
703352001939	non-specific DNA interactions [nucleotide binding]; other site
703352001940	DNA binding site [nucleotide binding]
703352001941	sequence specific DNA binding site [nucleotide binding]; other site
703352001942	putative cAMP binding site [chemical binding]; other site
703352001943	coproporphyrinogen III oxidase; Provisional; Region: PRK13347
703352001944	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
703352001945	FeS/SAM binding site; other site
703352001946	HemN C-terminal domain; Region: HemN_C; pfam06969
703352001947	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
703352001948	Major Facilitator Superfamily; Region: MFS_1; pfam07690
703352001949	putative substrate translocation pore; other site
703352001950	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
703352001951	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
703352001952	Helix-turn-helix domain; Region: HTH_18; pfam12833
703352001953	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
703352001954	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3216
703352001955	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
703352001956	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
703352001957	Catalytic site [active]
703352001958	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
703352001959	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
703352001960	ribonuclease III; Reviewed; Region: PRK12371
703352001961	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
703352001962	dimerization interface [polypeptide binding]; other site
703352001963	active site
703352001964	metal binding site [ion binding]; metal-binding site
703352001965	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
703352001966	dsRNA binding site [nucleotide binding]; other site
703352001967	GTPase Era; Reviewed; Region: era; PRK00089
703352001968	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
703352001969	G1 box; other site
703352001970	GTP/Mg2+ binding site [chemical binding]; other site
703352001971	Switch I region; other site
703352001972	G2 box; other site
703352001973	Switch II region; other site
703352001974	G3 box; other site
703352001975	G4 box; other site
703352001976	G5 box; other site
703352001977	KH domain; Region: KH_2; pfam07650
703352001978	Recombination protein O N terminal; Region: RecO_N; pfam11967
703352001979	DNA repair protein RecO; Region: reco; TIGR00613
703352001980	Recombination protein O C terminal; Region: RecO_C; pfam02565
703352001981	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350
703352001982	Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896
703352001983	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
703352001984	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
703352001985	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
703352001986	dihydroorotase; Validated; Region: PRK09060
703352001987	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
703352001988	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
703352001989	active site
703352001990	Protein of unknown function (DUF2385); Region: DUF2385; cl11490
703352001991	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
703352001992	nudix motif; other site
703352001993	Uncharacterized conserved protein [Function unknown]; Region: COG2135
703352001994	LysE type translocator; Region: LysE; cl00565
703352001995	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
703352001996	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
703352001997	active site
703352001998	HIGH motif; other site
703352001999	nucleotide binding site [chemical binding]; other site
703352002000	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
703352002001	KMSKS motif; other site
703352002002	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
703352002003	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
703352002004	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
703352002005	active site
703352002006	catalytic residues [active]
703352002007	metal binding site [ion binding]; metal-binding site
703352002008	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
703352002009	Predicted permeases [General function prediction only]; Region: RarD; COG2962
703352002010	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
703352002011	Peptidase family M23; Region: Peptidase_M23; pfam01551
703352002012	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
703352002013	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
703352002014	S-adenosylmethionine binding site [chemical binding]; other site
703352002015	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312
703352002016	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
703352002017	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
703352002018	SurA N-terminal domain; Region: SurA_N; pfam09312
703352002019	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
703352002020	OstA-like protein; Region: OstA; cl00844
703352002021	Organic solvent tolerance protein; Region: OstA_C; pfam04453
703352002022	Predicted permeases [General function prediction only]; Region: COG0795
703352002023	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
703352002024	Predicted permeases [General function prediction only]; Region: COG0795
703352002025	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
703352002026	multifunctional aminopeptidase A; Provisional; Region: PRK00913
703352002027	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
703352002028	interface (dimer of trimers) [polypeptide binding]; other site
703352002029	Substrate-binding/catalytic site; other site
703352002030	Zn-binding sites [ion binding]; other site
703352002031	DNA polymerase III subunit chi; Validated; Region: PRK05728
703352002032	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
703352002033	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
703352002034	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
703352002035	Walker A/P-loop; other site
703352002036	ATP binding site [chemical binding]; other site
703352002037	ABC transporter signature motif; other site
703352002038	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
703352002039	Walker B; other site
703352002040	D-loop; other site
703352002041	ABC transporter; Region: ABC_tran_2; pfam12848
703352002042	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
703352002043	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318
703352002044	DinB superfamily; Region: DinB_2; pfam12867
703352002045	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
703352002046	active site
703352002047	multimer interface [polypeptide binding]; other site
703352002048	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126
703352002049	Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187
703352002050	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
703352002051	MoaE homodimer interface [polypeptide binding]; other site
703352002052	MoaD interaction [polypeptide binding]; other site
703352002053	active site residues [active]
703352002054	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
703352002055	MoaE interaction surface [polypeptide binding]; other site
703352002056	MoeB interaction surface [polypeptide binding]; other site
703352002057	thiocarboxylated glycine; other site
703352002058	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
703352002059	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
703352002060	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
703352002061	GIY-YIG motif/motif A; other site
703352002062	active site
703352002063	catalytic site [active]
703352002064	putative DNA binding site [nucleotide binding]; other site
703352002065	metal binding site [ion binding]; metal-binding site
703352002066	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
703352002067	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
703352002068	short chain dehydrogenase; Provisional; Region: PRK09134
703352002069	pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357
703352002070	NADP binding site [chemical binding]; other site
703352002071	substrate binding pocket [chemical binding]; other site
703352002072	active site
703352002073	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
703352002074	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
703352002075	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
703352002076	putative C-terminal domain interface [polypeptide binding]; other site
703352002077	putative GSH binding site (G-site) [chemical binding]; other site
703352002078	putative dimer interface [polypeptide binding]; other site
703352002079	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
703352002080	dimer interface [polypeptide binding]; other site
703352002081	N-terminal domain interface [polypeptide binding]; other site
703352002082	putative substrate binding pocket (H-site) [chemical binding]; other site
703352002083	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
703352002084	B1 nucleotide binding pocket [chemical binding]; other site
703352002085	B2 nucleotide binding pocket [chemical binding]; other site
703352002086	CAS motifs; other site
703352002087	active site
703352002088	Bacteriophage capsid protein [General function prediction only]; Region: COG5511
703352002089	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
703352002090	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
703352002091	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
703352002092	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
703352002093	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
703352002094	putative [4Fe-4S] binding site [ion binding]; other site
703352002095	putative molybdopterin cofactor binding site [chemical binding]; other site
703352002096	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
703352002097	putative molybdopterin cofactor binding site; other site
703352002098	Protein of unknown function (DUF992); Region: DUF992; pfam06186
703352002099	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
703352002100	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
703352002101	active site
703352002102	substrate binding site [chemical binding]; other site
703352002103	cosubstrate binding site; other site
703352002104	catalytic site [active]
703352002105	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
703352002106	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
703352002107	dimerization interface [polypeptide binding]; other site
703352002108	putative ATP binding site [chemical binding]; other site
703352002109	Domain of unknown function DUF20; Region: UPF0118; pfam01594
703352002110	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
703352002111	hypothetical protein; Validated; Region: PRK09087
703352002112	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
703352002113	Walker A motif; other site
703352002114	ATP binding site [chemical binding]; other site
703352002115	Walker B motif; other site
703352002116	arginine finger; other site
703352002117	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
703352002118	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
703352002119	NAD(P) binding site [chemical binding]; other site
703352002120	active site
703352002121	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
703352002122	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
703352002123	putative NAD(P) binding site [chemical binding]; other site
703352002124	putative active site [active]
703352002125	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
703352002126	L-lactate permease; Region: Lactate_perm; cl00701
703352002127	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
703352002128	L-lactate permease; Region: Lactate_perm; cl00701
703352002129	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
703352002130	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
703352002131	active site
703352002132	substrate binding site [chemical binding]; other site
703352002133	catalytic site [active]
703352002134	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
703352002135	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
703352002136	Integrase core domain; Region: rve; pfam00665
703352002137	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
703352002138	Domain of unknown function (DUF955); Region: DUF955; pfam06114
703352002139	Uncharacterized protein containing a TIR (Toll-Interleukin 1-resistance) domain [Function unknown]; Region: COG4916
703352002140	TIR domain; Region: TIR_2; pfam13676
703352002141	Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991
703352002142	Bacterial SH3 domain; Region: SH3_3; pfam08239
703352002143	cystathionine beta-lyase; Provisional; Region: PRK05967
703352002144	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
703352002145	homodimer interface [polypeptide binding]; other site
703352002146	substrate-cofactor binding pocket; other site
703352002147	pyridoxal 5'-phosphate binding site [chemical binding]; other site
703352002148	catalytic residue [active]
703352002149	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
703352002150	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
703352002151	active site
703352002152	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
703352002153	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
703352002154	substrate binding pocket [chemical binding]; other site
703352002155	membrane-bound complex binding site; other site
703352002156	hinge residues; other site
703352002157	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
703352002158	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352002159	conserved gate region; other site
703352002160	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352002161	putative PBP binding loops; other site
703352002162	dimer interface [polypeptide binding]; other site
703352002163	ABC-ATPase subunit interface; other site
703352002164	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
703352002165	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352002166	dimer interface [polypeptide binding]; other site
703352002167	conserved gate region; other site
703352002168	putative PBP binding loops; other site
703352002169	ABC-ATPase subunit interface; other site
703352002170	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
703352002171	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
703352002172	Walker A/P-loop; other site
703352002173	ATP binding site [chemical binding]; other site
703352002174	Q-loop/lid; other site
703352002175	ABC transporter signature motif; other site
703352002176	Walker B; other site
703352002177	D-loop; other site
703352002178	H-loop/switch region; other site
703352002179	salicylate hydroxylase; Provisional; Region: PRK06475
703352002180	salicylate hydroxylase; Provisional; Region: PRK08163
703352002181	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391
703352002182	polyphosphate kinase; Provisional; Region: PRK05443
703352002183	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
703352002184	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
703352002185	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
703352002186	putative domain interface [polypeptide binding]; other site
703352002187	putative active site [active]
703352002188	catalytic site [active]
703352002189	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
703352002190	putative domain interface [polypeptide binding]; other site
703352002191	putative active site [active]
703352002192	catalytic site [active]
703352002193	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
703352002194	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
703352002195	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
703352002196	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
703352002197	catalytic site [active]
703352002198	putative active site [active]
703352002199	putative substrate binding site [chemical binding]; other site
703352002200	HRDC domain; Region: HRDC; pfam00570
703352002201	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
703352002202	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
703352002203	dimer interface [polypeptide binding]; other site
703352002204	anticodon binding site; other site
703352002205	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
703352002206	homodimer interface [polypeptide binding]; other site
703352002207	motif 1; other site
703352002208	active site
703352002209	motif 2; other site
703352002210	GAD domain; Region: GAD; pfam02938
703352002211	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
703352002212	active site
703352002213	motif 3; other site
703352002214	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
703352002215	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
703352002216	CAP-like domain; other site
703352002217	active site
703352002218	primary dimer interface [polypeptide binding]; other site
703352002219	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
703352002220	Putative arginyl-tRNA:protein arginylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG2935
703352002221	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
703352002222	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
703352002223	Predicted membrane protein/domain [Function unknown]; Region: COG1714
703352002224	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
703352002225	dimer interface [polypeptide binding]; other site
703352002226	allosteric magnesium binding site [ion binding]; other site
703352002227	active site
703352002228	aspartate-rich active site metal binding site; other site
703352002229	Schiff base residues; other site
703352002230	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
703352002231	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
703352002232	substrate binding site [chemical binding]; other site
703352002233	oxyanion hole (OAH) forming residues; other site
703352002234	trimer interface [polypeptide binding]; other site
703352002235	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
703352002236	Transcriptional regulators [Transcription]; Region: MarR; COG1846
703352002237	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
703352002238	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
703352002239	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
703352002240	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
703352002241	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
703352002242	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
703352002243	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
703352002244	dimer interface [polypeptide binding]; other site
703352002245	active site
703352002246	glycine-pyridoxal phosphate binding site [chemical binding]; other site
703352002247	folate binding site [chemical binding]; other site
703352002248	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
703352002249	ATP cone domain; Region: ATP-cone; pfam03477
703352002250	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
703352002251	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
703352002252	catalytic motif [active]
703352002253	Zn binding site [ion binding]; other site
703352002254	RibD C-terminal domain; Region: RibD_C; cl17279
703352002255	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
703352002256	Lumazine binding domain; Region: Lum_binding; pfam00677
703352002257	Lumazine binding domain; Region: Lum_binding; pfam00677
703352002258	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
703352002259	homopentamer interface [polypeptide binding]; other site
703352002260	active site
703352002261	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
703352002262	putative RNA binding site [nucleotide binding]; other site
703352002263	Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; COG3808
703352002264	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
703352002265	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
703352002266	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
703352002267	Uncharacterized conserved protein [Function unknown]; Region: COG5452
703352002268	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
703352002269	putative phosphate acyltransferase; Provisional; Region: PRK05331
703352002270	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
703352002271	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
703352002272	dimer interface [polypeptide binding]; other site
703352002273	active site
703352002274	CoA binding pocket [chemical binding]; other site
703352002275	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
703352002276	IHF - DNA interface [nucleotide binding]; other site
703352002277	IHF dimer interface [polypeptide binding]; other site
703352002278	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
703352002279	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
703352002280	DNA binding residues [nucleotide binding]
703352002281	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
703352002282	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
703352002283	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
703352002284	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
703352002285	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
703352002286	SLBB domain; Region: SLBB; pfam10531
703352002287	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
703352002288	Protein of unknown function (DUF2842); Region: DUF2842; pfam11003
703352002289	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
703352002290	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
703352002291	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
703352002292	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
703352002293	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
703352002294	oligomer interface [polypeptide binding]; other site
703352002295	putative active site [active]
703352002296	Mn binding site [ion binding]; other site
703352002297	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
703352002298	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
703352002299	23S rRNA interface [nucleotide binding]; other site
703352002300	L3 interface [polypeptide binding]; other site
703352002301	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
703352002302	CoenzymeA binding site [chemical binding]; other site
703352002303	subunit interaction site [polypeptide binding]; other site
703352002304	PHB binding site; other site
703352002305	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994
703352002306	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
703352002307	homodimer interface [polypeptide binding]; other site
703352002308	substrate-cofactor binding pocket; other site
703352002309	pyridoxal 5'-phosphate binding site [chemical binding]; other site
703352002310	catalytic residue [active]
703352002311	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
703352002312	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
703352002313	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
703352002314	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
703352002315	NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377
703352002316	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
703352002317	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
703352002318	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
703352002319	NADH dehydrogenase subunit D; Validated; Region: PRK06075
703352002320	NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905
703352002321	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
703352002322	putative dimer interface [polypeptide binding]; other site
703352002323	[2Fe-2S] cluster binding site [ion binding]; other site
703352002324	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
703352002325	SLBB domain; Region: SLBB; pfam10531
703352002326	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
703352002327	NADH dehydrogenase subunit G; Validated; Region: PRK09130
703352002328	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
703352002329	catalytic loop [active]
703352002330	iron binding site [ion binding]; other site
703352002331	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
703352002332	MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773
703352002333	Domain of unknown function (DUF1982); Region: DUF1982; pfam09326
703352002334	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
703352002335	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
703352002336	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
703352002337	4Fe-4S binding domain; Region: Fer4; pfam00037
703352002338	4Fe-4S binding domain; Region: Fer4; pfam00037
703352002339	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
703352002340	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
703352002341	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
703352002342	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
703352002343	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
703352002344	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
703352002345	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
703352002346	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
703352002347	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
703352002348	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
703352002349	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
703352002350	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
703352002351	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
703352002352	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
703352002353	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
703352002354	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
703352002355	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
703352002356	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
703352002357	dimer interface [polypeptide binding]; other site
703352002358	substrate binding site [chemical binding]; other site
703352002359	metal binding site [ion binding]; metal-binding site
703352002360	Predicted secreted protein [Function unknown]; Region: COG5454
703352002361	prolyl-tRNA synthetase; Provisional; Region: PRK12325
703352002362	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
703352002363	dimer interface [polypeptide binding]; other site
703352002364	motif 1; other site
703352002365	active site
703352002366	motif 2; other site
703352002367	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
703352002368	active site
703352002369	motif 3; other site
703352002370	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
703352002371	anticodon binding site; other site
703352002372	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
703352002373	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
703352002374	FtsX-like permease family; Region: FtsX; pfam02687
703352002375	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
703352002376	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
703352002377	Walker A/P-loop; other site
703352002378	ATP binding site [chemical binding]; other site
703352002379	Q-loop/lid; other site
703352002380	ABC transporter signature motif; other site
703352002381	Walker B; other site
703352002382	D-loop; other site
703352002383	H-loop/switch region; other site
703352002384	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
703352002385	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
703352002386	putative active site [active]
703352002387	putative PHP Thumb interface [polypeptide binding]; other site
703352002388	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
703352002389	generic binding surface II; other site
703352002390	generic binding surface I; other site
703352002391	Protein of unknwon function (DUF3008); Region: DUF3008; pfam11450
703352002392	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
703352002393	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
703352002394	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
703352002395	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
703352002396	RNA binding surface [nucleotide binding]; other site
703352002397	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
703352002398	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
703352002399	Ligand Binding Site [chemical binding]; other site
703352002400	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
703352002401	PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517
703352002402	active site
703352002403	putative lithium-binding site [ion binding]; other site
703352002404	substrate binding site [chemical binding]; other site
703352002405	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
703352002406	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
703352002407	putative substrate translocation pore; other site
703352002408	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
703352002409	putative GSH binding site [chemical binding]; other site
703352002410	catalytic residues [active]
703352002411	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
703352002412	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
703352002413	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
703352002414	dimerization interface [polypeptide binding]; other site
703352002415	ATP binding site [chemical binding]; other site
703352002416	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
703352002417	dimerization interface [polypeptide binding]; other site
703352002418	ATP binding site [chemical binding]; other site
703352002419	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
703352002420	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
703352002421	C-terminal domain interface [polypeptide binding]; other site
703352002422	GSH binding site (G-site) [chemical binding]; other site
703352002423	dimer interface [polypeptide binding]; other site
703352002424	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
703352002425	N-terminal domain interface [polypeptide binding]; other site
703352002426	dimer interface [polypeptide binding]; other site
703352002427	substrate binding pocket (H-site) [chemical binding]; other site
703352002428	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
703352002429	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
703352002430	putative active site [active]
703352002431	catalytic triad [active]
703352002432	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
703352002433	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
703352002434	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
703352002435	ATP binding site [chemical binding]; other site
703352002436	active site
703352002437	substrate binding site [chemical binding]; other site
703352002438	Uncharacterized conserved protein [Function unknown]; Region: COG5467
703352002439	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
703352002440	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
703352002441	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
703352002442	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
703352002443	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
703352002444	putative metal binding site [ion binding]; other site
703352002445	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
703352002446	active site
703352002447	adenylosuccinate lyase; Provisional; Region: PRK07492
703352002448	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
703352002449	tetramer interface [polypeptide binding]; other site
703352002450	active site
703352002451	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
703352002452	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
703352002453	substrate binding site [chemical binding]; other site
703352002454	hexamer interface [polypeptide binding]; other site
703352002455	metal binding site [ion binding]; metal-binding site
703352002456	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
703352002457	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
703352002458	putative acyl-acceptor binding pocket; other site
703352002459	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
703352002460	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266
703352002461	putative NAD(P) binding site [chemical binding]; other site
703352002462	structural Zn binding site [ion binding]; other site
703352002463	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501
703352002464	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
703352002465	dimer interface [polypeptide binding]; other site
703352002466	active site
703352002467	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519
703352002468	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
703352002469	active site
703352002470	acyl carrier protein; Provisional; Region: PRK06508
703352002471	Lysozyme family protein [General function prediction only]; Region: zliS; COG3926
703352002472	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
703352002473	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
703352002474	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
703352002475	active site
703352002476	catalytic residues [active]
703352002477	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
703352002478	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
703352002479	substrate binding site [chemical binding]; other site
703352002480	ATP binding site [chemical binding]; other site
703352002481	putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223
703352002482	Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454
703352002483	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
703352002484	PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306
703352002485	active site
703352002486	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
703352002487	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
703352002488	active site
703352002489	motif I; other site
703352002490	motif II; other site
703352002491	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
703352002492	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
703352002493	substrate binding pocket [chemical binding]; other site
703352002494	membrane-bound complex binding site; other site
703352002495	hinge residues; other site
703352002496	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
703352002497	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
703352002498	FMN binding site [chemical binding]; other site
703352002499	active site
703352002500	catalytic residues [active]
703352002501	substrate binding site [chemical binding]; other site
703352002502	Predicted aspartyl protease [General function prediction only]; Region: COG3577
703352002503	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
703352002504	catalytic motif [active]
703352002505	Catalytic residue [active]
703352002506	Predicted Fe-S protein [General function prediction only]; Region: COG3313
703352002507	cobalamin synthase; Reviewed; Region: cobS; PRK00235
703352002508	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
703352002509	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
703352002510	putative dimer interface [polypeptide binding]; other site
703352002511	active site pocket [active]
703352002512	putative cataytic base [active]
703352002513	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
703352002514	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
703352002515	putative DNA binding site [nucleotide binding]; other site
703352002516	putative Zn2+ binding site [ion binding]; other site
703352002517	AsnC family; Region: AsnC_trans_reg; pfam01037
703352002518	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
703352002519	putative uracil binding site [chemical binding]; other site
703352002520	putative active site [active]
703352002521	Staphylococcal nuclease homologues; Region: SNc; smart00318
703352002522	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
703352002523	Catalytic site; other site
703352002524	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
703352002525	Sel1-like repeats; Region: SEL1; smart00671
703352002526	potential frameshift: common BLAST hit: gi|376280552|ref|YP_005154558.1| exodeoxyribonuclease III
703352002527	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
703352002528	putative catalytic site [active]
703352002529	putative phosphate binding site [ion binding]; other site
703352002530	putative metal binding site [ion binding]; other site
703352002531	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
703352002532	putative metal binding site [ion binding]; other site
703352002533	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979
703352002534	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
703352002535	putative metal binding site [ion binding]; other site
703352002536	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
703352002537	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
703352002538	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
703352002539	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
703352002540	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
703352002541	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
703352002542	active site
703352002543	HIGH motif; other site
703352002544	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
703352002545	KMSK motif region; other site
703352002546	tRNA binding surface [nucleotide binding]; other site
703352002547	DALR anticodon binding domain; Region: DALR_1; smart00836
703352002548	anticodon binding site; other site
703352002549	Sporulation related domain; Region: SPOR; pfam05036
703352002550	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
703352002551	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
703352002552	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
703352002553	Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386
703352002554	twin arginine translocase protein A; Provisional; Region: tatA; PRK00720
703352002555	sec-independent translocase; Provisional; Region: PRK00708
703352002556	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
703352002557	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
703352002558	seryl-tRNA synthetase; Provisional; Region: PRK05431
703352002559	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
703352002560	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
703352002561	dimer interface [polypeptide binding]; other site
703352002562	active site
703352002563	motif 1; other site
703352002564	motif 2; other site
703352002565	motif 3; other site
703352002566	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
703352002567	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
703352002568	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
703352002569	S-adenosylmethionine binding site [chemical binding]; other site
703352002570	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
703352002571	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
703352002572	Peptidase family M23; Region: Peptidase_M23; pfam01551
703352002573	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
703352002574	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
703352002575	Walker A motif; other site
703352002576	ATP binding site [chemical binding]; other site
703352002577	Walker B motif; other site
703352002578	Preprotein translocase subunit YajC [Intracellular trafficking and secretion]; Region: YajC; COG1862
703352002579	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13023
703352002580	Protein export membrane protein; Region: SecD_SecF; cl14618
703352002581	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
703352002582	Protein export membrane protein; Region: SecD_SecF; pfam02355
703352002583	Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248
703352002584	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
703352002585	Glucose inhibited division protein A; Region: GIDA; pfam01134
703352002586	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
703352002587	Predicted membrane protein [Function unknown]; Region: COG4872
703352002588	Uncharacterized membrane-anchored protein [Function unknown]; Region: COG4929
703352002589	trigger factor; Provisional; Region: tig; PRK01490
703352002590	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
703352002591	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
703352002592	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
703352002593	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
703352002594	GatB domain; Region: GatB_Yqey; smart00845
703352002595	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
703352002596	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
703352002597	Coenzyme A binding pocket [chemical binding]; other site
703352002598	NADH dehydrogenase; Validated; Region: PRK08183
703352002599	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4765
703352002600	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
703352002601	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
703352002602	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
703352002603	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
703352002604	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
703352002605	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
703352002606	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
703352002607	carboxyltransferase (CT) interaction site; other site
703352002608	biotinylation site [posttranslational modification]; other site
703352002609	Dehydroquinase class II; Region: DHquinase_II; pfam01220
703352002610	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
703352002611	trimer interface [polypeptide binding]; other site
703352002612	active site
703352002613	dimer interface [polypeptide binding]; other site
703352002614	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
703352002615	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
703352002616	catalytic residues [active]
703352002617	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
703352002618	Peptidase family M48; Region: Peptidase_M48; cl12018
703352002619	aspartate aminotransferase; Provisional; Region: PRK05764
703352002620	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
703352002621	pyridoxal 5'-phosphate binding site [chemical binding]; other site
703352002622	homodimer interface [polypeptide binding]; other site
703352002623	catalytic residue [active]
703352002624	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
703352002625	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
703352002626	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
703352002627	AMIN domain; Region: AMIN; pfam11741
703352002628	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
703352002629	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
703352002630	active site
703352002631	metal binding site [ion binding]; metal-binding site
703352002632	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
703352002633	Transglycosylase; Region: Transgly; pfam00912
703352002634	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
703352002635	peptide chain release factor 2; Provisional; Region: PRK07342
703352002636	This domain is found in peptide chain release factors; Region: PCRF; smart00937
703352002637	RF-1 domain; Region: RF-1; pfam00472
703352002638	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
703352002639	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
703352002640	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
703352002641	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
703352002642	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
703352002643	dinuclear metal binding motif [ion binding]; other site
703352002644	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
703352002645	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
703352002646	catalytic triad [active]
703352002647	AsmA family; Region: AsmA; pfam05170
703352002648	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
703352002649	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
703352002650	active site
703352002651	HIGH motif; other site
703352002652	dimer interface [polypeptide binding]; other site
703352002653	KMSKS motif; other site
703352002654	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
703352002655	RNA binding surface [nucleotide binding]; other site
703352002656	Predicted molecular chaperone distantly related to HSP70-fold metalloproteases [Posttranslational modification, protein turnover, chaperones]; Region: COG2377
703352002657	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
703352002658	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
703352002659	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
703352002660	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
703352002661	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
703352002662	catalytic residue [active]
703352002663	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
703352002664	putative ABC transporter; Region: ycf24; CHL00085
703352002665	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
703352002666	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
703352002667	Walker A/P-loop; other site
703352002668	ATP binding site [chemical binding]; other site
703352002669	Q-loop/lid; other site
703352002670	ABC transporter signature motif; other site
703352002671	Walker B; other site
703352002672	D-loop; other site
703352002673	H-loop/switch region; other site
703352002674	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
703352002675	FeS assembly protein SufD; Region: sufD; TIGR01981
703352002676	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
703352002677	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
703352002678	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
703352002679	catalytic residue [active]
703352002680	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
703352002681	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
703352002682	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
703352002683	active site
703352002684	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
703352002685	ATP-NAD kinase; Region: NAD_kinase; pfam01513
703352002686	inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761
703352002687	helicase 45; Provisional; Region: PTZ00424
703352002688	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
703352002689	ATP binding site [chemical binding]; other site
703352002690	Mg++ binding site [ion binding]; other site
703352002691	motif III; other site
703352002692	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
703352002693	nucleotide binding region [chemical binding]; other site
703352002694	ATP-binding site [chemical binding]; other site
703352002695	FeS assembly scaffold SufA; Region: sufA_proteo; TIGR01997
703352002696	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
703352002697	metal-binding site [ion binding]
703352002698	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
703352002699	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
703352002700	S-adenosylmethionine binding site [chemical binding]; other site
703352002701	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
703352002702	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3827
703352002703	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
703352002704	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
703352002705	HIGH motif; other site
703352002706	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
703352002707	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
703352002708	active site
703352002709	KMSKS motif; other site
703352002710	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
703352002711	tRNA binding surface [nucleotide binding]; other site
703352002712	anticodon binding site; other site
703352002713	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
703352002714	Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067
703352002715	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
703352002716	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
703352002717	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
703352002718	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
703352002719	putative N-terminal domain interface [polypeptide binding]; other site
703352002720	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
703352002721	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
703352002722	substrate binding pocket [chemical binding]; other site
703352002723	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
703352002724	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
703352002725	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
703352002726	GTP binding site; other site
703352002727	molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361
703352002728	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
703352002729	FeS/SAM binding site; other site
703352002730	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
703352002731	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
703352002732	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
703352002733	hypothetical protein; Provisional; Region: PRK06753
703352002734	fumarate hydratase; Provisional; Region: PRK15389
703352002735	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
703352002736	Fumarase C-terminus; Region: Fumerase_C; pfam05683
703352002737	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
703352002738	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
703352002739	Transglycosylase associated protein; Region: Transgly_assoc; pfam04226
703352002740	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
703352002741	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
703352002742	active site
703352002743	Int/Topo IB signature motif; other site
703352002744	catalytic residues [active]
703352002745	DNA binding site [nucleotide binding]
703352002746	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
703352002747	Domain of unknown function (DUF4415); Region: DUF4415; cl01401
703352002748	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929
703352002749	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
703352002750	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
703352002751	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
703352002752	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
703352002753	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
703352002754	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
703352002755	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
703352002756	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
703352002757	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
703352002758	Lysozyme family protein [General function prediction only]; Region: zliS; COG3926
703352002759	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
703352002760	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
703352002761	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
703352002762	ArsC family; Region: ArsC; pfam03960
703352002763	catalytic residues [active]
703352002764	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
703352002765	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
703352002766	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
703352002767	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
703352002768	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
703352002769	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
703352002770	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
703352002771	TMP-binding site; other site
703352002772	ATP-binding site [chemical binding]; other site
703352002773	DNA polymerase III subunit delta'; Validated; Region: PRK09112
703352002774	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
703352002775	DNA polymerase III subunit delta'; Validated; Region: PRK08485
703352002776	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
703352002777	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
703352002778	active site
703352002779	HIGH motif; other site
703352002780	KMSKS motif; other site
703352002781	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
703352002782	tRNA binding surface [nucleotide binding]; other site
703352002783	anticodon binding site; other site
703352002784	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
703352002785	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
703352002786	active site
703352002787	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
703352002788	putative hydrolase; Provisional; Region: PRK02113
703352002789	cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657
703352002790	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
703352002791	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
703352002792	Walker A/P-loop; other site
703352002793	ATP binding site [chemical binding]; other site
703352002794	Q-loop/lid; other site
703352002795	ABC transporter signature motif; other site
703352002796	Walker B; other site
703352002797	D-loop; other site
703352002798	H-loop/switch region; other site
703352002799	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
703352002800	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
703352002801	active site
703352002802	EamA-like transporter family; Region: EamA; pfam00892
703352002803	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
703352002804	EamA-like transporter family; Region: EamA; pfam00892
703352002805	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
703352002806	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
703352002807	motif I; other site
703352002808	active site
703352002809	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
703352002810	motif II; other site
703352002811	Chaperone required for the assembly of the mitochondrial F1-ATPase [Posttranslational modification, protein turnover, chaperones]; Region: COG5387
703352002812	glutamine synthetase; Provisional; Region: glnA; PRK09469
703352002813	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
703352002814	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
703352002815	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
703352002816	Nitrogen regulatory protein P-II; Region: P-II; smart00938
703352002817	Uncharacterized conserved protein [Function unknown]; Region: COG0062
703352002818	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
703352002819	putative substrate binding site [chemical binding]; other site
703352002820	putative ATP binding site [chemical binding]; other site
703352002821	phosphoglycolate phosphatase; Provisional; Region: PRK13222
703352002822	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
703352002823	motif II; other site
703352002824	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
703352002825	tetramer (dimer of dimers) interface [polypeptide binding]; other site
703352002826	active site
703352002827	dimer interface [polypeptide binding]; other site
703352002828	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3184
703352002829	glutathione reductase; Validated; Region: PRK06116
703352002830	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
703352002831	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
703352002832	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
703352002833	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
703352002834	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
703352002835	NAD synthetase; Provisional; Region: PRK13981
703352002836	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
703352002837	multimer interface [polypeptide binding]; other site
703352002838	active site
703352002839	catalytic triad [active]
703352002840	protein interface 1 [polypeptide binding]; other site
703352002841	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
703352002842	homodimer interface [polypeptide binding]; other site
703352002843	NAD binding pocket [chemical binding]; other site
703352002844	ATP binding pocket [chemical binding]; other site
703352002845	Mg binding site [ion binding]; other site
703352002846	active-site loop [active]
703352002847	glutamyl-tRNA synthetase; Provisional; Region: PRK12558
703352002848	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
703352002849	active site
703352002850	HIGH motif; other site
703352002851	nucleotide binding site [chemical binding]; other site
703352002852	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
703352002853	active site
703352002854	KMSKS motif; other site
703352002855	malic enzyme; Reviewed; Region: PRK12862
703352002856	Malic enzyme, N-terminal domain; Region: malic; pfam00390
703352002857	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
703352002858	putative NAD(P) binding site [chemical binding]; other site
703352002859	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
703352002860	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
703352002861	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
703352002862	active site
703352002863	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
703352002864	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
703352002865	Permease; Region: Permease; pfam02405
703352002866	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
703352002867	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
703352002868	Walker A/P-loop; other site
703352002869	ATP binding site [chemical binding]; other site
703352002870	Q-loop/lid; other site
703352002871	ABC transporter signature motif; other site
703352002872	Walker B; other site
703352002873	D-loop; other site
703352002874	H-loop/switch region; other site
703352002875	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
703352002876	mce related protein; Region: MCE; pfam02470
703352002877	ABC-type uncharacterized transport system, auxiliary component [General function prediction only]; Region: COG3218
703352002878	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
703352002879	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
703352002880	chromosome segregation protein; Provisional; Region: PRK02224
703352002881	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
703352002882	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
703352002883	catalytic loop [active]
703352002884	iron binding site [ion binding]; other site
703352002885	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
703352002886	Predicted secreted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5661
703352002887	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
703352002888	dihydropteroate synthase; Region: DHPS; TIGR01496
703352002889	substrate binding pocket [chemical binding]; other site
703352002890	dimer interface [polypeptide binding]; other site
703352002891	inhibitor binding site; inhibition site
703352002892	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
703352002893	homooctamer interface [polypeptide binding]; other site
703352002894	active site
703352002895	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
703352002896	catalytic center binding site [active]
703352002897	ATP binding site [chemical binding]; other site
703352002898	Predicted membrane protein [Function unknown]; Region: COG3768
703352002899	Domain of unknown function (DUF697); Region: DUF697; cl12064
703352002900	YcjX-like family, DUF463; Region: DUF463; cl01193
703352002901	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
703352002902	catalytic core [active]
703352002903	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
703352002904	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
703352002905	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
703352002906	PAS domain; Region: PAS_9; pfam13426
703352002907	putative active site [active]
703352002908	heme pocket [chemical binding]; other site
703352002909	PAS fold; Region: PAS_4; pfam08448
703352002910	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
703352002911	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
703352002912	dimer interface [polypeptide binding]; other site
703352002913	phosphorylation site [posttranslational modification]
703352002914	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
703352002915	ATP binding site [chemical binding]; other site
703352002916	Mg2+ binding site [ion binding]; other site
703352002917	G-X-G motif; other site
703352002918	Response regulator receiver domain; Region: Response_reg; pfam00072
703352002919	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
703352002920	active site
703352002921	phosphorylation site [posttranslational modification]
703352002922	intermolecular recognition site; other site
703352002923	dimerization interface [polypeptide binding]; other site
703352002924	Predicted flavoproteins [General function prediction only]; Region: COG2081
703352002925	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
703352002926	Beta-lactamase; Region: Beta-lactamase; pfam00144
703352002927	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
703352002928	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
703352002929	Mechanosensitive ion channel; Region: MS_channel; pfam00924
703352002930	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562
703352002931	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
703352002932	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
703352002933	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
703352002934	active site
703352002935	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
703352002936	TSCPD domain; Region: TSCPD; pfam12637
703352002937	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666
703352002938	nudix motif; other site
703352002939	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
703352002940	active site
703352002941	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
703352002942	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
703352002943	Ligand Binding Site [chemical binding]; other site
703352002944	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
703352002945	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
703352002946	putative MPT binding site; other site
703352002947	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
703352002948	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
703352002949	threonine dehydratase; Validated; Region: PRK08639
703352002950	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
703352002951	tetramer interface [polypeptide binding]; other site
703352002952	pyridoxal 5'-phosphate binding site [chemical binding]; other site
703352002953	catalytic residue [active]
703352002954	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
703352002955	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
703352002956	DEAD-like helicases superfamily; Region: DEXDc; smart00487
703352002957	ATP binding site [chemical binding]; other site
703352002958	Mg++ binding site [ion binding]; other site
703352002959	motif III; other site
703352002960	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
703352002961	nucleotide binding region [chemical binding]; other site
703352002962	ATP-binding site [chemical binding]; other site
703352002963	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
703352002964	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
703352002965	dimer interface [polypeptide binding]; other site
703352002966	pyridoxal 5'-phosphate binding site [chemical binding]; other site
703352002967	catalytic residue [active]
703352002968	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
703352002969	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
703352002970	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
703352002971	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
703352002972	active site residue [active]
703352002973	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
703352002974	active site residue [active]
703352002975	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
703352002976	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
703352002977	Coenzyme A binding pocket [chemical binding]; other site
703352002978	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
703352002979	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
703352002980	metal binding site [ion binding]; metal-binding site
703352002981	active site
703352002982	I-site; other site
703352002983	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
703352002984	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
703352002985	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
703352002986	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
703352002987	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
703352002988	putative substrate translocation pore; other site
703352002989	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
703352002990	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
703352002991	HlyD family secretion protein; Region: HlyD_3; pfam13437
703352002992	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
703352002993	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
703352002994	putative NAD(P) binding site [chemical binding]; other site
703352002995	putative substrate binding site [chemical binding]; other site
703352002996	catalytic Zn binding site [ion binding]; other site
703352002997	structural Zn binding site [ion binding]; other site
703352002998	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
703352002999	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
703352003000	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
703352003001	active site
703352003002	Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976
703352003003	Tetratricopeptide repeat; Region: TPR_1; pfam00515
703352003004	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
703352003005	S-adenosylmethionine binding site [chemical binding]; other site
703352003006	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
703352003007	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
703352003008	UDP-glucose 4-epimerase; Region: PLN02240
703352003009	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
703352003010	NAD binding site [chemical binding]; other site
703352003011	homodimer interface [polypeptide binding]; other site
703352003012	active site
703352003013	substrate binding site [chemical binding]; other site
703352003014	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
703352003015	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
703352003016	homodimer interface [polypeptide binding]; other site
703352003017	metal binding site [ion binding]; metal-binding site
703352003018	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
703352003019	homodimer interface [polypeptide binding]; other site
703352003020	active site
703352003021	putative chemical substrate binding site [chemical binding]; other site
703352003022	metal binding site [ion binding]; metal-binding site
703352003023	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
703352003024	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
703352003025	putative FMN binding site [chemical binding]; other site
703352003026	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
703352003027	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
703352003028	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
703352003029	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
703352003030	active site
703352003031	dimer interface [polypeptide binding]; other site
703352003032	motif 1; other site
703352003033	motif 2; other site
703352003034	motif 3; other site
703352003035	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
703352003036	anticodon binding site; other site
703352003037	potential frameshift: common BLAST hit: gi|340790690|ref|YP_004756155.1| D-alanyl-D-alanine carboxypeptidase
703352003038	Sporulation related domain; Region: SPOR; pfam05036
703352003039	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
703352003040	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
703352003041	hypothetical protein; Validated; Region: PRK00041
703352003042	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
703352003043	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
703352003044	trimerization site [polypeptide binding]; other site
703352003045	active site
703352003046	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
703352003047	homodecamer interface [polypeptide binding]; other site
703352003048	GTP cyclohydrolase I; Provisional; Region: PLN03044
703352003049	active site
703352003050	putative catalytic site residues [active]
703352003051	zinc binding site [ion binding]; other site
703352003052	GTP-CH-I/GFRP interaction surface; other site
703352003053	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
703352003054	hypothetical protein; Provisional; Region: PRK10279
703352003055	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
703352003056	nucleophile elbow; other site
703352003057	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
703352003058	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
703352003059	active site
703352003060	DNA binding site [nucleotide binding]
703352003061	Int/Topo IB signature motif; other site
703352003062	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
703352003063	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
703352003064	BRO family, N-terminal domain; Region: Bro-N; cl10591
703352003065	Prophage antirepressor [Transcription]; Region: COG3617
703352003066	BRO family, N-terminal domain; Region: Bro-N; smart01040
703352003067	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
703352003068	CoA-transferase family III; Region: CoA_transf_3; pfam02515
703352003069	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
703352003070	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
703352003071	FAD binding site [chemical binding]; other site
703352003072	substrate binding pocket [chemical binding]; other site
703352003073	catalytic base [active]
703352003074	Transcriptional regulator [Transcription]; Region: LysR; COG0583
703352003075	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
703352003076	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
703352003077	dimerization interface [polypeptide binding]; other site
703352003078	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
703352003079	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
703352003080	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
703352003081	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
703352003082	multidrug efflux protein; Reviewed; Region: PRK09579
703352003083	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
703352003084	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
703352003085	HlyD family secretion protein; Region: HlyD_3; pfam13437
703352003086	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
703352003087	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
703352003088	potential frameshift: common BLAST hit: gi|376280763|ref|YP_005154769.1| queuine tRNA-ribosyltransferase
703352003089	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
703352003090	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
703352003091	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
703352003092	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
703352003093	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
703352003094	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
703352003095	active site
703352003096	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
703352003097	active site
703352003098	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
703352003099	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
703352003100	active site
703352003101	(T/H)XGH motif; other site
703352003102	DNA gyrase subunit A; Validated; Region: PRK05560
703352003103	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
703352003104	CAP-like domain; other site
703352003105	active site
703352003106	primary dimer interface [polypeptide binding]; other site
703352003107	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
703352003108	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
703352003109	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
703352003110	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
703352003111	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
703352003112	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
703352003113	Uncharacterized component of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3709
703352003114	phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325
703352003115	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
703352003116	DNA-binding site [nucleotide binding]; DNA binding site
703352003117	UTRA domain; Region: UTRA; pfam07702
703352003118	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
703352003119	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
703352003120	dimer interface [polypeptide binding]; other site
703352003121	ssDNA binding site [nucleotide binding]; other site
703352003122	tetramer (dimer of dimers) interface [polypeptide binding]; other site
703352003123	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
703352003124	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
703352003125	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
703352003126	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
703352003127	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
703352003128	IHF dimer interface [polypeptide binding]; other site
703352003129	IHF - DNA interface [nucleotide binding]; other site
703352003130	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
703352003131	Found in ATP-dependent protease La (LON); Region: LON; smart00464
703352003132	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
703352003133	Walker A motif; other site
703352003134	ATP binding site [chemical binding]; other site
703352003135	Walker B motif; other site
703352003136	arginine finger; other site
703352003137	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
703352003138	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
703352003139	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
703352003140	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
703352003141	Walker A motif; other site
703352003142	ATP binding site [chemical binding]; other site
703352003143	Walker B motif; other site
703352003144	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
703352003145	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
703352003146	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
703352003147	oligomer interface [polypeptide binding]; other site
703352003148	active site residues [active]
703352003149	GTPases [General function prediction only]; Region: HflX; COG2262
703352003150	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
703352003151	HflX GTPase family; Region: HflX; cd01878
703352003152	G1 box; other site
703352003153	GTP/Mg2+ binding site [chemical binding]; other site
703352003154	Switch I region; other site
703352003155	G2 box; other site
703352003156	G3 box; other site
703352003157	Switch II region; other site
703352003158	G4 box; other site
703352003159	G5 box; other site
703352003160	bacterial Hfq-like; Region: Hfq; cd01716
703352003161	hexamer interface [polypeptide binding]; other site
703352003162	Sm1 motif; other site
703352003163	RNA binding site [nucleotide binding]; other site
703352003164	Sm2 motif; other site
703352003165	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
703352003166	TrkA-N domain; Region: TrkA_N; pfam02254
703352003167	TrkA-C domain; Region: TrkA_C; pfam02080
703352003168	TrkA-N domain; Region: TrkA_N; pfam02254
703352003169	TrkA-C domain; Region: TrkA_C; pfam02080
703352003170	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
703352003171	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
703352003172	active site
703352003173	phosphorylation site [posttranslational modification]
703352003174	intermolecular recognition site; other site
703352003175	dimerization interface [polypeptide binding]; other site
703352003176	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
703352003177	Walker A motif; other site
703352003178	ATP binding site [chemical binding]; other site
703352003179	Walker B motif; other site
703352003180	arginine finger; other site
703352003181	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
703352003182	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
703352003183	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
703352003184	dimerization interface [polypeptide binding]; other site
703352003185	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
703352003186	dimer interface [polypeptide binding]; other site
703352003187	phosphorylation site [posttranslational modification]
703352003188	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
703352003189	ATP binding site [chemical binding]; other site
703352003190	Mg2+ binding site [ion binding]; other site
703352003191	G-X-G motif; other site
703352003192	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
703352003193	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
703352003194	active site
703352003195	phosphorylation site [posttranslational modification]
703352003196	intermolecular recognition site; other site
703352003197	dimerization interface [polypeptide binding]; other site
703352003198	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
703352003199	Walker A motif; other site
703352003200	ATP binding site [chemical binding]; other site
703352003201	Walker B motif; other site
703352003202	arginine finger; other site
703352003203	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
703352003204	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
703352003205	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
703352003206	dimer interface [polypeptide binding]; other site
703352003207	phosphorylation site [posttranslational modification]
703352003208	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
703352003209	ATP binding site [chemical binding]; other site
703352003210	Mg2+ binding site [ion binding]; other site
703352003211	G-X-G motif; other site
703352003212	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
703352003213	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
703352003214	FMN binding site [chemical binding]; other site
703352003215	active site
703352003216	catalytic residues [active]
703352003217	substrate binding site [chemical binding]; other site
703352003218	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
703352003219	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
703352003220	substrate binding site; other site
703352003221	dimer interface; other site
703352003222	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
703352003223	homotrimer interaction site [polypeptide binding]; other site
703352003224	zinc binding site [ion binding]; other site
703352003225	CDP-binding sites; other site
703352003226	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
703352003227	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
703352003228	classical (c) SDRs; Region: SDR_c; cd05233
703352003229	NAD(P) binding site [chemical binding]; other site
703352003230	active site
703352003231	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
703352003232	putative coenzyme Q binding site [chemical binding]; other site
703352003233	lipoyl synthase; Provisional; Region: PRK05481
703352003234	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
703352003235	FeS/SAM binding site; other site
703352003236	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
703352003237	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
703352003238	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
703352003239	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
703352003240	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
703352003241	pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349
703352003242	E3 interaction surface; other site
703352003243	lipoyl attachment site [posttranslational modification]; other site
703352003244	e3 binding domain; Region: E3_binding; pfam02817
703352003245	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
703352003246	pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892
703352003247	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
703352003248	E3 interaction surface; other site
703352003249	lipoyl attachment site [posttranslational modification]; other site
703352003250	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
703352003251	alpha subunit interface [polypeptide binding]; other site
703352003252	TPP binding site [chemical binding]; other site
703352003253	heterodimer interface [polypeptide binding]; other site
703352003254	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
703352003255	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
703352003256	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
703352003257	tetramer interface [polypeptide binding]; other site
703352003258	TPP-binding site [chemical binding]; other site
703352003259	heterodimer interface [polypeptide binding]; other site
703352003260	phosphorylation loop region [posttranslational modification]
703352003261	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
703352003262	Septum formation initiator; Region: DivIC; pfam04977
703352003263	Methyltransferase domain; Region: Methyltransf_23; pfam13489
703352003264	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
703352003265	S-adenosylmethionine binding site [chemical binding]; other site
703352003266	enolase; Provisional; Region: eno; PRK00077
703352003267	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
703352003268	dimer interface [polypeptide binding]; other site
703352003269	metal binding site [ion binding]; metal-binding site
703352003270	substrate binding pocket [chemical binding]; other site
703352003271	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
703352003272	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
703352003273	CTP synthetase; Validated; Region: pyrG; PRK05380
703352003274	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
703352003275	Catalytic site [active]
703352003276	active site
703352003277	UTP binding site [chemical binding]; other site
703352003278	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
703352003279	active site
703352003280	putative oxyanion hole; other site
703352003281	catalytic triad [active]
703352003282	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
703352003283	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
703352003284	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
703352003285	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
703352003286	triosephosphate isomerase; Provisional; Region: PRK14565
703352003287	substrate binding site [chemical binding]; other site
703352003288	dimer interface [polypeptide binding]; other site
703352003289	catalytic triad [active]
703352003290	SurA N-terminal domain; Region: SurA_N_3; cl07813
703352003291	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
703352003292	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
703352003293	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
703352003294	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
703352003295	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
703352003296	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
703352003297	active site
703352003298	ribulose/triose binding site [chemical binding]; other site
703352003299	phosphate binding site [ion binding]; other site
703352003300	substrate (anthranilate) binding pocket [chemical binding]; other site
703352003301	product (indole) binding pocket [chemical binding]; other site
703352003302	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
703352003303	trimer interface [polypeptide binding]; other site
703352003304	dimer interface [polypeptide binding]; other site
703352003305	putative active site [active]
703352003306	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
703352003307	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
703352003308	dimer interface [polypeptide binding]; other site
703352003309	putative functional site; other site
703352003310	putative MPT binding site; other site
703352003311	LexA repressor; Validated; Region: PRK00215
703352003312	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
703352003313	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
703352003314	Catalytic site [active]
703352003315	Competence protein; Region: Competence; pfam03772
703352003316	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
703352003317	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
703352003318	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
703352003319	active site
703352003320	HIGH motif; other site
703352003321	nucleotide binding site [chemical binding]; other site
703352003322	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
703352003323	active site
703352003324	KMSKS motif; other site
703352003325	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
703352003326	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
703352003327	dimer interface [polypeptide binding]; other site
703352003328	active site
703352003329	citrylCoA binding site [chemical binding]; other site
703352003330	NADH binding [chemical binding]; other site
703352003331	cationic pore residues; other site
703352003332	oxalacetate/citrate binding site [chemical binding]; other site
703352003333	coenzyme A binding site [chemical binding]; other site
703352003334	catalytic triad [active]
703352003335	Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763
703352003336	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
703352003337	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3494
703352003338	Acyl-[acyl carrier protein]; Region: LpxA; COG1043
703352003339	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
703352003340	active site
703352003341	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
703352003342	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
703352003343	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
703352003344	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
703352003345	trimer interface [polypeptide binding]; other site
703352003346	active site
703352003347	UDP-GlcNAc binding site [chemical binding]; other site
703352003348	lipid binding site [chemical binding]; lipid-binding site
703352003349	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
703352003350	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
703352003351	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
703352003352	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
703352003353	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
703352003354	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
703352003355	Surface antigen; Region: Bac_surface_Ag; pfam01103
703352003356	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
703352003357	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
703352003358	active site
703352003359	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
703352003360	protein binding site [polypeptide binding]; other site
703352003361	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
703352003362	putative substrate binding region [chemical binding]; other site
703352003363	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
703352003364	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
703352003365	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834
703352003366	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
703352003367	catalytic residue [active]
703352003368	putative FPP diphosphate  binding site; other site
703352003369	putative FPP binding hydrophobic cleft; other site
703352003370	dimer interface [polypeptide binding]; other site
703352003371	putative IPP diphosphate binding site; other site
703352003372	ribosome recycling factor; Reviewed; Region: frr; PRK00083
703352003373	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
703352003374	hinge region; other site
703352003375	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
703352003376	putative nucleotide binding site [chemical binding]; other site
703352003377	uridine monophosphate binding site [chemical binding]; other site
703352003378	homohexameric interface [polypeptide binding]; other site
703352003379	elongation factor Ts; Provisional; Region: tsf; PRK09377
703352003380	UBA/TS-N domain; Region: UBA; pfam00627
703352003381	Elongation factor TS; Region: EF_TS; pfam00889
703352003382	Elongation factor TS; Region: EF_TS; pfam00889
703352003383	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
703352003384	rRNA interaction site [nucleotide binding]; other site
703352003385	S8 interaction site; other site
703352003386	putative laminin-1 binding site; other site
703352003387	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
703352003388	Domain of unknown function (DUF1849); Region: DUF1849; pfam08904
703352003389	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
703352003390	homotrimer interaction site [polypeptide binding]; other site
703352003391	putative active site [active]
703352003392	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_3; cd08585
703352003393	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
703352003394	putative active site [active]
703352003395	catalytic site [active]
703352003396	putative metal binding site [ion binding]; other site
703352003397	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146
703352003398	Protein of unknown function, DUF482; Region: DUF482; pfam04339
703352003399	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
703352003400	HIT family signature motif; other site
703352003401	catalytic residue [active]
703352003402	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
703352003403	Clp amino terminal domain; Region: Clp_N; pfam02861
703352003404	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
703352003405	Walker A motif; other site
703352003406	ATP binding site [chemical binding]; other site
703352003407	Walker B motif; other site
703352003408	arginine finger; other site
703352003409	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
703352003410	Walker A motif; other site
703352003411	ATP binding site [chemical binding]; other site
703352003412	Walker B motif; other site
703352003413	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
703352003414	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933
703352003415	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
703352003416	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
703352003417	Sporulation related domain; Region: SPOR; pfam05036
703352003418	Uncharacterized conserved protein [Function unknown]; Region: COG5458
703352003419	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
703352003420	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
703352003421	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
703352003422	Uncharacterized conserved protein [Function unknown]; Region: COG1434
703352003423	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
703352003424	putative active site [active]
703352003425	Protein of unknown function (DUF1624); Region: DUF1624; pfam07786
703352003426	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
703352003427	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
703352003428	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
703352003429	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
703352003430	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3803
703352003431	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
703352003432	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
703352003433	non-specific DNA binding site [nucleotide binding]; other site
703352003434	salt bridge; other site
703352003435	sequence-specific DNA binding site [nucleotide binding]; other site
703352003436	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
703352003437	Domain of unknown function (DUF955); Region: DUF955; pfam06114
703352003438	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
703352003439	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
703352003440	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
703352003441	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
703352003442	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
703352003443	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
703352003444	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
703352003445	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
703352003446	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
703352003447	carboxyltransferase (CT) interaction site; other site
703352003448	biotinylation site [posttranslational modification]; other site
703352003449	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
703352003450	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
703352003451	active site
703352003452	substrate binding site [chemical binding]; other site
703352003453	coenzyme B12 binding site [chemical binding]; other site
703352003454	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
703352003455	B12 binding site [chemical binding]; other site
703352003456	cobalt ligand [ion binding]; other site
703352003457	TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123
703352003458	DctM-like transporters; Region: DctM; pfam06808
703352003459	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
703352003460	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
703352003461	glutamate racemase; Provisional; Region: PRK00865
703352003462	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
703352003463	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
703352003464	intracellular protease, PfpI family; Region: PfpI; TIGR01382
703352003465	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
703352003466	conserved cys residue [active]
703352003467	Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321
703352003468	isocitrate dehydrogenase; Validated; Region: PRK08299
703352003469	alkaline phosphatase; Provisional; Region: PRK10518
703352003470	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
703352003471	dimer interface [polypeptide binding]; other site
703352003472	active site
703352003473	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
703352003474	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
703352003475	motif 1; other site
703352003476	active site
703352003477	motif 2; other site
703352003478	motif 3; other site
703352003479	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
703352003480	recombinase A; Provisional; Region: recA; PRK09354
703352003481	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
703352003482	hexamer interface [polypeptide binding]; other site
703352003483	Walker A motif; other site
703352003484	ATP binding site [chemical binding]; other site
703352003485	Walker B motif; other site
703352003486	putative outer membrane lipoprotein; Provisional; Region: PRK10510
703352003487	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
703352003488	ligand binding site [chemical binding]; other site
703352003489	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
703352003490	N-acetyl-D-glucosamine binding site [chemical binding]; other site
703352003491	catalytic residue [active]
703352003492	recombination factor protein RarA; Reviewed; Region: PRK13342
703352003493	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
703352003494	Walker A motif; other site
703352003495	ATP binding site [chemical binding]; other site
703352003496	Walker B motif; other site
703352003497	arginine finger; other site
703352003498	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
703352003499	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
703352003500	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
703352003501	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
703352003502	protein binding site [polypeptide binding]; other site
703352003503	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
703352003504	protein binding site [polypeptide binding]; other site
703352003505	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
703352003506	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
703352003507	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
703352003508	alphaNTD homodimer interface [polypeptide binding]; other site
703352003509	alphaNTD - beta interaction site [polypeptide binding]; other site
703352003510	alphaNTD - beta' interaction site [polypeptide binding]; other site
703352003511	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
703352003512	30S ribosomal protein S11; Validated; Region: PRK05309
703352003513	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
703352003514	30S ribosomal protein S13; Region: bact_S13; TIGR03631
703352003515	adenylate kinase; Reviewed; Region: adk; PRK00279
703352003516	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
703352003517	AMP-binding site [chemical binding]; other site
703352003518	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
703352003519	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
703352003520	SecY translocase; Region: SecY; pfam00344
703352003521	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
703352003522	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
703352003523	23S rRNA binding site [nucleotide binding]; other site
703352003524	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
703352003525	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
703352003526	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
703352003527	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
703352003528	5S rRNA interface [nucleotide binding]; other site
703352003529	23S rRNA interface [nucleotide binding]; other site
703352003530	L5 interface [polypeptide binding]; other site
703352003531	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
703352003532	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
703352003533	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
703352003534	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
703352003535	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
703352003536	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
703352003537	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
703352003538	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
703352003539	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
703352003540	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
703352003541	RNA binding site [nucleotide binding]; other site
703352003542	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
703352003543	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
703352003544	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
703352003545	23S rRNA interface [nucleotide binding]; other site
703352003546	putative translocon interaction site; other site
703352003547	signal recognition particle (SRP54) interaction site; other site
703352003548	L23 interface [polypeptide binding]; other site
703352003549	trigger factor interaction site; other site
703352003550	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
703352003551	23S rRNA interface [nucleotide binding]; other site
703352003552	5S rRNA interface [nucleotide binding]; other site
703352003553	putative antibiotic binding site [chemical binding]; other site
703352003554	L25 interface [polypeptide binding]; other site
703352003555	L27 interface [polypeptide binding]; other site
703352003556	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
703352003557	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
703352003558	G-X-X-G motif; other site
703352003559	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
703352003560	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
703352003561	putative translocon binding site; other site
703352003562	protein-rRNA interface [nucleotide binding]; other site
703352003563	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
703352003564	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
703352003565	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
703352003566	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
703352003567	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
703352003568	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
703352003569	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
703352003570	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
703352003571	elongation factor Tu; Reviewed; Region: PRK00049
703352003572	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
703352003573	G1 box; other site
703352003574	GEF interaction site [polypeptide binding]; other site
703352003575	GTP/Mg2+ binding site [chemical binding]; other site
703352003576	Switch I region; other site
703352003577	G2 box; other site
703352003578	G3 box; other site
703352003579	Switch II region; other site
703352003580	G4 box; other site
703352003581	G5 box; other site
703352003582	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
703352003583	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
703352003584	Antibiotic Binding Site [chemical binding]; other site
703352003585	elongation factor G; Reviewed; Region: PRK00007
703352003586	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
703352003587	G1 box; other site
703352003588	putative GEF interaction site [polypeptide binding]; other site
703352003589	GTP/Mg2+ binding site [chemical binding]; other site
703352003590	Switch I region; other site
703352003591	G2 box; other site
703352003592	G3 box; other site
703352003593	Switch II region; other site
703352003594	G4 box; other site
703352003595	G5 box; other site
703352003596	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
703352003597	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
703352003598	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
703352003599	30S ribosomal protein S7; Validated; Region: PRK05302
703352003600	Ribosomal protein S12-like family; composed of prokaryotic 30S ribosomal protein S12, eukaryotic 40S ribosomal protein S23 and similar proteins. S12 and S23 are located at the interface of the large and small ribosomal subunits, adjacent to the decoding...; Region: Ribosomal_S12_like; cl00312
703352003601	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
703352003602	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
703352003603	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
703352003604	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
703352003605	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
703352003606	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
703352003607	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
703352003608	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
703352003609	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
703352003610	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
703352003611	DNA binding site [nucleotide binding]
703352003612	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
703352003613	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
703352003614	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
703352003615	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
703352003616	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
703352003617	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
703352003618	RPB11 interaction site [polypeptide binding]; other site
703352003619	RPB12 interaction site [polypeptide binding]; other site
703352003620	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
703352003621	RPB1 interaction site [polypeptide binding]; other site
703352003622	RPB11 interaction site [polypeptide binding]; other site
703352003623	RPB10 interaction site [polypeptide binding]; other site
703352003624	RPB3 interaction site [polypeptide binding]; other site
703352003625	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
703352003626	L11 interface [polypeptide binding]; other site
703352003627	putative EF-Tu interaction site [polypeptide binding]; other site
703352003628	putative EF-G interaction site [polypeptide binding]; other site
703352003629	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
703352003630	23S rRNA interface [nucleotide binding]; other site
703352003631	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
703352003632	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
703352003633	mRNA/rRNA interface [nucleotide binding]; other site
703352003634	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
703352003635	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
703352003636	23S rRNA interface [nucleotide binding]; other site
703352003637	L7/L12 interface [polypeptide binding]; other site
703352003638	putative thiostrepton binding site; other site
703352003639	L25 interface [polypeptide binding]; other site
703352003640	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
703352003641	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
703352003642	putative homodimer interface [polypeptide binding]; other site
703352003643	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
703352003644	heterodimer interface [polypeptide binding]; other site
703352003645	homodimer interface [polypeptide binding]; other site
703352003646	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
703352003647	potential frameshift: common BLAST hit: gi|340790867|ref|YP_004756332.1| translation elongation factor Tu
703352003648	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
703352003649	Antibiotic Binding Site [chemical binding]; other site
703352003650	potential frameshift: common BLAST hit: gi|340790867|ref|YP_004756332.1| translation elongation factor Tu
703352003651	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
703352003652	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
703352003653	G1 box; other site
703352003654	GEF interaction site [polypeptide binding]; other site
703352003655	GTP/Mg2+ binding site [chemical binding]; other site
703352003656	Switch I region; other site
703352003657	G2 box; other site
703352003658	G3 box; other site
703352003659	Switch II region; other site
703352003660	G4 box; other site
703352003661	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
703352003662	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
703352003663	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
703352003664	FOG: CBS domain [General function prediction only]; Region: COG0517
703352003665	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
703352003666	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
703352003667	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388
703352003668	PAS domain; Region: PAS_5; pfam07310
703352003669	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035
703352003670	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
703352003671	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
703352003672	trimer interface [polypeptide binding]; other site
703352003673	putative metal binding site [ion binding]; other site
703352003674	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
703352003675	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
703352003676	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
703352003677	Protein of unknown function (DUF3126); Region: DUF3126; pfam11324
703352003678	serine acetyltransferase; Provisional; Region: cysE; PRK11132
703352003679	Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971
703352003680	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
703352003681	trimer interface [polypeptide binding]; other site
703352003682	active site
703352003683	substrate binding site [chemical binding]; other site
703352003684	CoA binding site [chemical binding]; other site
703352003685	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
703352003686	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
703352003687	Uncharacterized conserved protein [Function unknown]; Region: COG1430
703352003688	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
703352003689	DNA-binding site [nucleotide binding]; DNA binding site
703352003690	RNA-binding motif; other site
703352003691	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
703352003692	DNA-binding site [nucleotide binding]; DNA binding site
703352003693	RNA-binding motif; other site
703352003694	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
703352003695	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
703352003696	dimer interface [polypeptide binding]; other site
703352003697	active site
703352003698	metal binding site [ion binding]; metal-binding site
703352003699	glutathione binding site [chemical binding]; other site
703352003700	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395
703352003701	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
703352003702	DHH family; Region: DHH; pfam01368
703352003703	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
703352003704	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
703352003705	ATP-grasp domain; Region: ATP-grasp_4; cl17255
703352003706	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
703352003707	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
703352003708	putative active site [active]
703352003709	homoserine dehydrogenase; Provisional; Region: PRK06349
703352003710	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
703352003711	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
703352003712	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
703352003713	aminotransferase; Validated; Region: PRK09148
703352003714	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
703352003715	pyridoxal 5'-phosphate binding site [chemical binding]; other site
703352003716	homodimer interface [polypeptide binding]; other site
703352003717	catalytic residue [active]
703352003718	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
703352003719	Peptidase M15; Region: Peptidase_M15_3; cl01194
703352003720	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3553
703352003721	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
703352003722	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
703352003723	active site
703352003724	DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003
703352003725	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
703352003726	MPN+ (JAMM) motif; other site
703352003727	Zinc-binding site [ion binding]; other site
703352003728	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
703352003729	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
703352003730	active site
703352003731	SAM binding site [chemical binding]; other site
703352003732	putative homodimer interface [polypeptide binding]; other site
703352003733	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
703352003734	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
703352003735	S-adenosylmethionine binding site [chemical binding]; other site
703352003736	precorrin-3B synthase; Region: CobG; TIGR02435
703352003737	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
703352003738	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
703352003739	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
703352003740	Precorrin-8X methylmutase; Region: CbiC; pfam02570
703352003741	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
703352003742	active site
703352003743	SAM binding site [chemical binding]; other site
703352003744	homodimer interface [polypeptide binding]; other site
703352003745	Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073
703352003746	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
703352003747	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
703352003748	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
703352003749	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
703352003750	active site
703352003751	SAM binding site [chemical binding]; other site
703352003752	homodimer interface [polypeptide binding]; other site
703352003753	potential frameshift: common BLAST hit: gi|340790908|ref|YP_004756373.1| phospholipase/carboxylesterase
703352003754	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
703352003755	potential frameshift: common BLAST hit: gi|376272978|ref|YP_005151556.1| phospholipase/carboxylesterase
703352003756	TIGR02099 family protein; Region: TIGR02099
703352003757	Flavin Reductases; Region: FlaRed; cl00801
703352003758	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
703352003759	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
703352003760	ligand binding site [chemical binding]; other site
703352003761	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
703352003762	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
703352003763	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
703352003764	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
703352003765	pyridoxal 5'-phosphate binding site [chemical binding]; other site
703352003766	homodimer interface [polypeptide binding]; other site
703352003767	catalytic residue [active]
703352003768	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
703352003769	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
703352003770	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
703352003771	active site
703352003772	SAM binding site [chemical binding]; other site
703352003773	homodimer interface [polypeptide binding]; other site
703352003774	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
703352003775	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
703352003776	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
703352003777	active site
703352003778	SAM binding site [chemical binding]; other site
703352003779	homodimer interface [polypeptide binding]; other site
703352003780	Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073
703352003781	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
703352003782	tellurium resistance terB-like protein; Region: terB_like; cd07177
703352003783	metal binding site [ion binding]; metal-binding site
703352003784	hypothetical protein; Provisional; Region: PRK10621
703352003785	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
703352003786	Predicted membrane protein [Function unknown]; Region: COG2510
703352003787	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
703352003788	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
703352003789	homodimer interface [polypeptide binding]; other site
703352003790	Walker A motif; other site
703352003791	ATP binding site [chemical binding]; other site
703352003792	hydroxycobalamin binding site [chemical binding]; other site
703352003793	Walker B motif; other site
703352003794	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
703352003795	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
703352003796	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
703352003797	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
703352003798	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
703352003799	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
703352003800	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
703352003801	homotrimer interface [polypeptide binding]; other site
703352003802	Walker A motif; other site
703352003803	GTP binding site [chemical binding]; other site
703352003804	Walker B motif; other site
703352003805	Predicted integral membrane protein [Function unknown]; Region: COG5446
703352003806	cobalt transporter subunit CbtB (proposed); Region: CbtB; TIGR02459
703352003807	cobyric acid synthase; Provisional; Region: PRK00784
703352003808	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
703352003809	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
703352003810	catalytic triad [active]
703352003811	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
703352003812	Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162
703352003813	substrate binding pocket [chemical binding]; other site
703352003814	FAD binding site [chemical binding]; other site
703352003815	catalytic base [active]
703352003816	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
703352003817	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
703352003818	Predicted small secreted protein [Function unknown]; Region: COG5510
703352003819	Transcriptional regulator [Transcription]; Region: LysR; COG0583
703352003820	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
703352003821	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
703352003822	dimerization interface [polypeptide binding]; other site
703352003823	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
703352003824	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
703352003825	conserved cys residue [active]
703352003826	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
703352003827	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
703352003828	potential frameshift: common BLAST hit: gi|17986967|ref|NP_539601.1| sarcosine dehydrogenase
703352003829	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
703352003830	hydroxyglutarate oxidase; Provisional; Region: PRK11728
703352003831	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
703352003832	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
703352003833	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
703352003834	Mechanosensitive ion channel; Region: MS_channel; pfam00924
703352003835	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
703352003836	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
703352003837	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
703352003838	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
703352003839	Protein export membrane protein; Region: SecD_SecF; pfam02355
703352003840	putative cation:proton antiport protein; Provisional; Region: PRK10669
703352003841	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
703352003842	TrkA-N domain; Region: TrkA_N; pfam02254
703352003843	Predicted integral membrane protein [Function unknown]; Region: COG0392
703352003844	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
703352003845	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
703352003846	sulfate transport protein; Provisional; Region: cysT; CHL00187
703352003847	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352003848	dimer interface [polypeptide binding]; other site
703352003849	conserved gate region; other site
703352003850	putative PBP binding loops; other site
703352003851	ABC-ATPase subunit interface; other site
703352003852	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
703352003853	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352003854	dimer interface [polypeptide binding]; other site
703352003855	conserved gate region; other site
703352003856	putative PBP binding loops; other site
703352003857	ABC-ATPase subunit interface; other site
703352003858	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
703352003859	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
703352003860	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
703352003861	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
703352003862	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
703352003863	Transporter associated domain; Region: CorC_HlyC; smart01091
703352003864	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
703352003865	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
703352003866	Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154
703352003867	short chain dehydrogenase; Provisional; Region: PRK06198
703352003868	classical (c) SDRs; Region: SDR_c; cd05233
703352003869	NAD(P) binding site [chemical binding]; other site
703352003870	active site
703352003871	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
703352003872	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
703352003873	Walker A/P-loop; other site
703352003874	ATP binding site [chemical binding]; other site
703352003875	Q-loop/lid; other site
703352003876	ABC transporter signature motif; other site
703352003877	Walker B; other site
703352003878	D-loop; other site
703352003879	H-loop/switch region; other site
703352003880	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
703352003881	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
703352003882	TM-ABC transporter signature motif; other site
703352003883	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312
703352003884	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
703352003885	putative ligand binding site [chemical binding]; other site
703352003886	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
703352003887	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
703352003888	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
703352003889	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
703352003890	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
703352003891	Walker A/P-loop; other site
703352003892	ATP binding site [chemical binding]; other site
703352003893	Q-loop/lid; other site
703352003894	ABC transporter signature motif; other site
703352003895	Walker B; other site
703352003896	D-loop; other site
703352003897	H-loop/switch region; other site
703352003898	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
703352003899	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
703352003900	ABC-ATPase subunit  interface; other site
703352003901	dimer interface [polypeptide binding]; other site
703352003902	putative PBP binding regions; other site
703352003903	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
703352003904	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
703352003905	intersubunit interface [polypeptide binding]; other site
703352003906	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
703352003907	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
703352003908	N-terminal plug; other site
703352003909	ligand-binding site [chemical binding]; other site
703352003910	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
703352003911	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
703352003912	potential frameshift: common BLAST hit: gi|376281015|ref|YP_005155021.1| ABC transporter ATP-binding protein/permease
703352003913	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
703352003914	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
703352003915	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
703352003916	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
703352003917	Walker A/P-loop; other site
703352003918	ATP binding site [chemical binding]; other site
703352003919	Q-loop/lid; other site
703352003920	ABC transporter signature motif; other site
703352003921	Walker B; other site
703352003922	D-loop; other site
703352003923	H-loop/switch region; other site
703352003924	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
703352003925	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
703352003926	Walker A/P-loop; other site
703352003927	ATP binding site [chemical binding]; other site
703352003928	Q-loop/lid; other site
703352003929	ABC transporter signature motif; other site
703352003930	Walker B; other site
703352003931	D-loop; other site
703352003932	H-loop/switch region; other site
703352003933	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
703352003934	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
703352003935	HlyD family secretion protein; Region: HlyD_3; pfam13437
703352003936	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
703352003937	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
703352003938	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
703352003939	alpha-gamma subunit interface [polypeptide binding]; other site
703352003940	beta-gamma subunit interface [polypeptide binding]; other site
703352003941	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
703352003942	alpha-beta subunit interface [polypeptide binding]; other site
703352003943	urease subunit alpha; Reviewed; Region: ureC; PRK13309
703352003944	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
703352003945	subunit interactions [polypeptide binding]; other site
703352003946	active site
703352003947	flap region; other site
703352003948	urease accessory protein UreE; Provisional; Region: ureE; PRK14711
703352003949	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
703352003950	dimer interface [polypeptide binding]; other site
703352003951	catalytic residues [active]
703352003952	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
703352003953	UreF; Region: UreF; pfam01730
703352003954	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
703352003955	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
703352003956	Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413
703352003957	ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266
703352003958	cobalt transport protein CbiM; Validated; Region: PRK06265
703352003959	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
703352003960	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
703352003961	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
703352003962	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
703352003963	Walker A/P-loop; other site
703352003964	ATP binding site [chemical binding]; other site
703352003965	Q-loop/lid; other site
703352003966	ABC transporter signature motif; other site
703352003967	Walker B; other site
703352003968	D-loop; other site
703352003969	H-loop/switch region; other site
703352003970	camphor resistance protein CrcB; Provisional; Region: ccrB; PRK01636
703352003971	Uncharacterized conserved protein [Function unknown]; Region: COG3439
703352003972	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
703352003973	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
703352003974	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
703352003975	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
703352003976	nudix motif; other site
703352003977	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
703352003978	putative catalytic site [active]
703352003979	putative metal binding site [ion binding]; other site
703352003980	putative phosphate binding site [ion binding]; other site
703352003981	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
703352003982	putative metal binding site [ion binding]; other site
703352003983	BA14K-like protein; Region: BA14K; pfam07886
703352003984	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
703352003985	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
703352003986	pyridoxal 5'-phosphate binding site [chemical binding]; other site
703352003987	homodimer interface [polypeptide binding]; other site
703352003988	catalytic residue [active]
703352003989	ketol-acid reductoisomerase; Provisional; Region: PRK05479
703352003990	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
703352003991	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
703352003992	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
703352003993	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
703352003994	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
703352003995	potassium uptake protein; Region: kup; TIGR00794
703352003996	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
703352003997	active site
703352003998	hydrophilic channel; other site
703352003999	dimerization interface [polypeptide binding]; other site
703352004000	catalytic residues [active]
703352004001	active site lid [active]
703352004002	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
703352004003	ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507
703352004004	AAA domain; Region: AAA_30; pfam13604
703352004005	Family description; Region: UvrD_C_2; pfam13538
703352004006	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
703352004007	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
703352004008	putative valine binding site [chemical binding]; other site
703352004009	dimer interface [polypeptide binding]; other site
703352004010	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
703352004011	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107
703352004012	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
703352004013	PYR/PP interface [polypeptide binding]; other site
703352004014	dimer interface [polypeptide binding]; other site
703352004015	TPP binding site [chemical binding]; other site
703352004016	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
703352004017	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
703352004018	TPP-binding site [chemical binding]; other site
703352004019	dimer interface [polypeptide binding]; other site
703352004020	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
703352004021	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
703352004022	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
703352004023	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
703352004024	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
703352004025	motif II; other site
703352004026	Predicted flavoproteins [General function prediction only]; Region: COG2081
703352004027	Predicted flavoproteins [General function prediction only]; Region: COG2081
703352004028	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
703352004029	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
703352004030	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
703352004031	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
703352004032	protein binding site [polypeptide binding]; other site
703352004033	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
703352004034	protein binding site [polypeptide binding]; other site
703352004035	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242
703352004036	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
703352004037	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
703352004038	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
703352004039	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
703352004040	HflK protein; Region: hflK; TIGR01933
703352004041	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
703352004042	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
703352004043	folate binding site [chemical binding]; other site
703352004044	NADP+ binding site [chemical binding]; other site
703352004045	thymidylate synthase; Reviewed; Region: thyA; PRK01827
703352004046	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
703352004047	dimerization interface [polypeptide binding]; other site
703352004048	active site
703352004049	Protein of unknown function (DUF2853); Region: DUF2853; pfam11015
703352004050	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
703352004051	putative substrate translocation pore; other site
703352004052	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
703352004053	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
703352004054	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
703352004055	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814
703352004056	Domain of unknown function (DUF4169); Region: DUF4169; pfam13770
703352004057	Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321
703352004058	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
703352004059	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
703352004060	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
703352004061	FAD binding domain; Region: FAD_binding_4; pfam01565
703352004062	Uncharacterized conserved protein [Function unknown]; Region: COG4702
703352004063	serine/threonine protein kinase; Provisional; Region: PRK09188
703352004064	serine/threonine protein kinase; Provisional; Region: PRK12274
703352004065	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
703352004066	Part of AAA domain; Region: AAA_19; pfam13245
703352004067	Family description; Region: UvrD_C_2; pfam13538
703352004068	Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045
703352004069	CreA protein; Region: CreA; pfam05981
703352004070	phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308
703352004071	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
703352004072	trimer interface [polypeptide binding]; other site
703352004073	active site
703352004074	substrate binding site [chemical binding]; other site
703352004075	CoA binding site [chemical binding]; other site
703352004076	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
703352004077	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
703352004078	Cu(I) binding site [ion binding]; other site
703352004079	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
703352004080	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
703352004081	S-adenosylmethionine binding site [chemical binding]; other site
703352004082	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
703352004083	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
703352004084	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
703352004085	active site
703352004086	Uncharacterized conserved protein [Function unknown]; Region: COG5587
703352004087	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
703352004088	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
703352004089	nucleotide binding pocket [chemical binding]; other site
703352004090	K-X-D-G motif; other site
703352004091	catalytic site [active]
703352004092	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
703352004093	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
703352004094	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
703352004095	Dimer interface [polypeptide binding]; other site
703352004096	BRCT sequence motif; other site
703352004097	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
703352004098	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
703352004099	Walker A/P-loop; other site
703352004100	ATP binding site [chemical binding]; other site
703352004101	Q-loop/lid; other site
703352004102	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
703352004103	ABC transporter signature motif; other site
703352004104	Walker B; other site
703352004105	D-loop; other site
703352004106	H-loop/switch region; other site
703352004107	DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105
703352004108	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
703352004109	binding surface
703352004110	TPR motif; other site
703352004111	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
703352004112	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
703352004113	cell division protein FtsZ; Validated; Region: PRK09330
703352004114	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
703352004115	nucleotide binding site [chemical binding]; other site
703352004116	SulA interaction site; other site
703352004117	cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483
703352004118	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
703352004119	Cell division protein FtsA; Region: FtsA; smart00842
703352004120	Cell division protein FtsA; Region: FtsA; pfam14450
703352004121	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
703352004122	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
703352004123	Cell division protein FtsQ; Region: FtsQ; pfam03799
703352004124	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
703352004125	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
703352004126	ATP-grasp domain; Region: ATP-grasp_4; cl17255
703352004127	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
703352004128	FAD binding domain; Region: FAD_binding_4; pfam01565
703352004129	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
703352004130	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
703352004131	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
703352004132	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
703352004133	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
703352004134	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
703352004135	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
703352004136	active site
703352004137	homodimer interface [polypeptide binding]; other site
703352004138	cell division protein FtsW; Region: ftsW; TIGR02614
703352004139	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390
703352004140	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
703352004141	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
703352004142	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
703352004143	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
703352004144	Mg++ binding site [ion binding]; other site
703352004145	putative catalytic motif [active]
703352004146	putative substrate binding site [chemical binding]; other site
703352004147	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093
703352004148	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
703352004149	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
703352004150	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
703352004151	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
703352004152	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
703352004153	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
703352004154	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
703352004155	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
703352004156	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
703352004157	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
703352004158	Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462
703352004159	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
703352004160	MraW methylase family; Region: Methyltransf_5; cl17771
703352004161	manganese transport protein MntH; Reviewed; Region: PRK00701
703352004162	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
703352004163	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
703352004164	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
703352004165	N-acetyl-D-glucosamine binding site [chemical binding]; other site
703352004166	catalytic residue [active]
703352004167	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
703352004168	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
703352004169	amidase catalytic site [active]
703352004170	Zn binding residues [ion binding]; other site
703352004171	substrate binding site [chemical binding]; other site
703352004172	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
703352004173	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
703352004174	DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076
703352004175	putative metal binding site [ion binding]; other site
703352004176	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
703352004177	HSP70 interaction site [polypeptide binding]; other site
703352004178	Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413
703352004179	active site
703352004180	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
703352004181	Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951
703352004182	murein hydrolase B; Provisional; Region: PRK10760; cl17906
703352004183	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
703352004184	Predicted permeases [General function prediction only]; Region: COG0679
703352004185	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
703352004186	FAD binding site [chemical binding]; other site
703352004187	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
703352004188	dimerization interface [polypeptide binding]; other site
703352004189	putative DNA binding site [nucleotide binding]; other site
703352004190	putative Zn2+ binding site [ion binding]; other site
703352004191	Methyltransferase domain; Region: Methyltransf_23; pfam13489
703352004192	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
703352004193	S-adenosylmethionine binding site [chemical binding]; other site
703352004194	Uncharacterized conserved protein [Function unknown]; Region: COG5586
703352004195	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
703352004196	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
703352004197	putative substrate translocation pore; other site
703352004198	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
703352004199	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
703352004200	S-adenosylmethionine binding site [chemical binding]; other site
703352004201	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
703352004202	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
703352004203	Walker A/P-loop; other site
703352004204	ATP binding site [chemical binding]; other site
703352004205	Q-loop/lid; other site
703352004206	ABC transporter signature motif; other site
703352004207	Walker B; other site
703352004208	D-loop; other site
703352004209	H-loop/switch region; other site
703352004210	ABC transporter; Region: ABC_tran_2; pfam12848
703352004211	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
703352004212	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
703352004213	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
703352004214	PGAP1-like protein; Region: PGAP1; pfam07819
703352004215	Protein of unknown function (DUF1498); Region: DUF1498; pfam07385
703352004216	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
703352004217	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
703352004218	[2Fe-2S] cluster binding site [ion binding]; other site
703352004219	C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884
703352004220	putative alpha subunit interface [polypeptide binding]; other site
703352004221	putative active site [active]
703352004222	putative substrate binding site [chemical binding]; other site
703352004223	Fe binding site [ion binding]; other site
703352004224	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
703352004225	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
703352004226	FAD binding pocket [chemical binding]; other site
703352004227	FAD binding motif [chemical binding]; other site
703352004228	phosphate binding motif [ion binding]; other site
703352004229	beta-alpha-beta structure motif; other site
703352004230	NAD binding pocket [chemical binding]; other site
703352004231	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
703352004232	catalytic loop [active]
703352004233	iron binding site [ion binding]; other site
703352004234	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
703352004235	PhnA protein; Region: PhnA; pfam03831
703352004236	Isochorismatase family; Region: Isochorismatase; pfam00857
703352004237	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
703352004238	catalytic triad [active]
703352004239	metal binding site [ion binding]; metal-binding site
703352004240	conserved cis-peptide bond; other site
703352004241	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899
703352004242	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
703352004243	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
703352004244	active site
703352004245	outer membrane protein; Region: OMP_w_GlyGly; TIGR04219
703352004246	Invasion associated locus B (IalB) protein; Region: IalB; cl02207
703352004247	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
703352004248	DNA binding site [nucleotide binding]
703352004249	active site
703352004250	Int/Topo IB signature motif; other site
703352004251	Uncharacterized conserved protein [Function unknown]; Region: COG2968
703352004252	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
703352004253	hypothetical protein; Provisional; Region: PRK05170
703352004254	Uncharacterized conserved protein [Function unknown]; Region: COG5453
703352004255	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
703352004256	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
703352004257	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
703352004258	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
703352004259	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
703352004260	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
703352004261	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
703352004262	DNA binding residues [nucleotide binding]
703352004263	DNA primase; Validated; Region: dnaG; PRK05667
703352004264	CHC2 zinc finger; Region: zf-CHC2; pfam01807
703352004265	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
703352004266	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
703352004267	active site
703352004268	metal binding site [ion binding]; metal-binding site
703352004269	interdomain interaction site; other site
703352004270	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
703352004271	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
703352004272	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
703352004273	PhoU domain; Region: PhoU; pfam01895
703352004274	PhoU domain; Region: PhoU; pfam01895
703352004275	Uncharacterized conserved protein [Function unknown]; Region: COG1610
703352004276	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
703352004277	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
703352004278	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
703352004279	catalytic site [active]
703352004280	subunit interface [polypeptide binding]; other site
703352004281	Predicted metalloprotease [General function prediction only]; Region: COG2321
703352004282	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
703352004283	Predicted membrane protein [Function unknown]; Region: COG5395
703352004284	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
703352004285	LytTr DNA-binding domain; Region: LytTR; cl04498
703352004286	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
703352004287	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
703352004288	ATP-grasp domain; Region: ATP-grasp_4; cl17255
703352004289	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
703352004290	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
703352004291	ATP-grasp domain; Region: ATP-grasp_4; cl17255
703352004292	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
703352004293	IMP binding site; other site
703352004294	dimer interface [polypeptide binding]; other site
703352004295	partial ornithine binding site; other site
703352004296	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
703352004297	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
703352004298	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
703352004299	NUDIX domain; Region: NUDIX; pfam00293
703352004300	nudix motif; other site
703352004301	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
703352004302	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
703352004303	putative C-terminal domain interface [polypeptide binding]; other site
703352004304	putative GSH binding site (G-site) [chemical binding]; other site
703352004305	putative dimer interface [polypeptide binding]; other site
703352004306	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
703352004307	N-terminal domain interface [polypeptide binding]; other site
703352004308	dimer interface [polypeptide binding]; other site
703352004309	substrate binding pocket (H-site) [chemical binding]; other site
703352004310	aspartate aminotransferase; Provisional; Region: PRK05764
703352004311	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
703352004312	pyridoxal 5'-phosphate binding site [chemical binding]; other site
703352004313	homodimer interface [polypeptide binding]; other site
703352004314	catalytic residue [active]
703352004315	Transcriptional regulator [Transcription]; Region: LysR; COG0583
703352004316	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
703352004317	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
703352004318	putative effector binding pocket; other site
703352004319	dimerization interface [polypeptide binding]; other site
703352004320	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
703352004321	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
703352004322	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
703352004323	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
703352004324	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
703352004325	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
703352004326	putative DNA binding site [nucleotide binding]; other site
703352004327	putative Zn2+ binding site [ion binding]; other site
703352004328	AsnC family; Region: AsnC_trans_reg; pfam01037
703352004329	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
703352004330	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
703352004331	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
703352004332	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
703352004333	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
703352004334	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
703352004335	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
703352004336	EamA-like transporter family; Region: EamA; pfam00892
703352004337	EamA-like transporter family; Region: EamA; pfam00892
703352004338	Protein of unknown function, DUF486; Region: DUF486; cl01236
703352004339	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921
703352004340	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
703352004341	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
703352004342	Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991
703352004343	Bacterial SH3 domain; Region: SH3_3; pfam08239
703352004344	excinuclease ABC subunit B; Provisional; Region: PRK05298
703352004345	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
703352004346	ATP binding site [chemical binding]; other site
703352004347	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
703352004348	nucleotide binding region [chemical binding]; other site
703352004349	ATP-binding site [chemical binding]; other site
703352004350	Ultra-violet resistance protein B; Region: UvrB; pfam12344
703352004351	UvrB/uvrC motif; Region: UVR; pfam02151
703352004352	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
703352004353	N-acetyl-D-glucosamine binding site [chemical binding]; other site
703352004354	catalytic residue [active]
703352004355	BA14K-like protein; Region: BA14K; pfam07886
703352004356	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
703352004357	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
703352004358	MarR family; Region: MarR_2; pfam12802
703352004359	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
703352004360	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
703352004361	active site
703352004362	phosphorylation site [posttranslational modification]
703352004363	intermolecular recognition site; other site
703352004364	dimerization interface [polypeptide binding]; other site
703352004365	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
703352004366	DNA binding site [nucleotide binding]
703352004367	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
703352004368	dimer interface [polypeptide binding]; other site
703352004369	phosphorylation site [posttranslational modification]
703352004370	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
703352004371	ATP binding site [chemical binding]; other site
703352004372	Mg2+ binding site [ion binding]; other site
703352004373	G-X-G motif; other site
703352004374	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
703352004375	dimer interface [polypeptide binding]; other site
703352004376	putative tRNA-binding site [nucleotide binding]; other site
703352004377	Uncharacterized conserved protein [Function unknown]; Region: COG5465
703352004378	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960
703352004379	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
703352004380	Uncharacterized conserved protein [Function unknown]; Region: COG1565
703352004381	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
703352004382	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
703352004383	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
703352004384	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
703352004385	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
703352004386	active site
703352004387	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
703352004388	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
703352004389	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
703352004390	active site
703352004391	HerA helicase [Replication, recombination, and repair]; Region: COG0433
703352004392	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
703352004393	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
703352004394	5S rRNA interface [nucleotide binding]; other site
703352004395	CTC domain interface [polypeptide binding]; other site
703352004396	L16 interface [polypeptide binding]; other site
703352004397	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
703352004398	putative active site [active]
703352004399	catalytic residue [active]
703352004400	GTP-binding protein YchF; Reviewed; Region: PRK09601
703352004401	YchF GTPase; Region: YchF; cd01900
703352004402	G1 box; other site
703352004403	GTP/Mg2+ binding site [chemical binding]; other site
703352004404	Switch I region; other site
703352004405	G2 box; other site
703352004406	Switch II region; other site
703352004407	G3 box; other site
703352004408	G4 box; other site
703352004409	G5 box; other site
703352004410	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
703352004411	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
703352004412	putative active site [active]
703352004413	putative catalytic site [active]
703352004414	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
703352004415	putative active site [active]
703352004416	putative catalytic site [active]
703352004417	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
703352004418	active site
703352004419	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
703352004420	cytochrome b; Provisional; Region: CYTB; MTH00191
703352004421	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
703352004422	Qi binding site; other site
703352004423	intrachain domain interface; other site
703352004424	interchain domain interface [polypeptide binding]; other site
703352004425	heme bH binding site [chemical binding]; other site
703352004426	heme bL binding site [chemical binding]; other site
703352004427	Qo binding site; other site
703352004428	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
703352004429	interchain domain interface [polypeptide binding]; other site
703352004430	intrachain domain interface; other site
703352004431	Qi binding site; other site
703352004432	Qo binding site; other site
703352004433	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
703352004434	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
703352004435	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
703352004436	[2Fe-2S] cluster binding site [ion binding]; other site
703352004437	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
703352004438	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
703352004439	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
703352004440	Walker A/P-loop; other site
703352004441	ATP binding site [chemical binding]; other site
703352004442	Q-loop/lid; other site
703352004443	ABC transporter signature motif; other site
703352004444	Walker B; other site
703352004445	D-loop; other site
703352004446	H-loop/switch region; other site
703352004447	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
703352004448	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
703352004449	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
703352004450	Walker A/P-loop; other site
703352004451	ATP binding site [chemical binding]; other site
703352004452	Q-loop/lid; other site
703352004453	ABC transporter signature motif; other site
703352004454	Walker B; other site
703352004455	D-loop; other site
703352004456	H-loop/switch region; other site
703352004457	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
703352004458	Purine nucleoside permease [Nucleotide transport and metabolism]; Region: NUP; COG5042
703352004459	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
703352004460	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752
703352004461	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
703352004462	Coenzyme A binding pocket [chemical binding]; other site
703352004463	Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820
703352004464	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
703352004465	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
703352004466	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
703352004467	active site
703352004468	NTP binding site [chemical binding]; other site
703352004469	metal binding triad [ion binding]; metal-binding site
703352004470	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
703352004471	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
703352004472	putative active site [active]
703352004473	putative CoA binding site [chemical binding]; other site
703352004474	nudix motif; other site
703352004475	metal binding site [ion binding]; metal-binding site
703352004476	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816
703352004477	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
703352004478	MoxR-like ATPases [General function prediction only]; Region: COG0714
703352004479	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
703352004480	ATP binding site [chemical binding]; other site
703352004481	Walker B motif; other site
703352004482	arginine finger; other site
703352004483	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
703352004484	Protein of unknown function DUF58; Region: DUF58; pfam01882
703352004485	N-terminal double-transmembrane domain; Region: two_anch; TIGR02226
703352004486	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
703352004487	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
703352004488	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
703352004489	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
703352004490	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
703352004491	Coenzyme A binding pocket [chemical binding]; other site
703352004492	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
703352004493	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
703352004494	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
703352004495	putative dimer interface [polypeptide binding]; other site
703352004496	N-terminal domain interface [polypeptide binding]; other site
703352004497	putative substrate binding pocket (H-site) [chemical binding]; other site
703352004498	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
703352004499	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680
703352004500	nudix motif; other site
703352004501	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
703352004502	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
703352004503	active site
703352004504	metal binding site [ion binding]; metal-binding site
703352004505	2-isopropylmalate synthase; Validated; Region: PRK03739
703352004506	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
703352004507	active site
703352004508	catalytic residues [active]
703352004509	metal binding site [ion binding]; metal-binding site
703352004510	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
703352004511	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
703352004512	Cation efflux family; Region: Cation_efflux; pfam01545
703352004513	anthranilate synthase; Provisional; Region: PRK13566
703352004514	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
703352004515	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
703352004516	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
703352004517	glutamine binding [chemical binding]; other site
703352004518	catalytic triad [active]
703352004519	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
703352004520	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
703352004521	putative DNA binding site [nucleotide binding]; other site
703352004522	putative Zn2+ binding site [ion binding]; other site
703352004523	AsnC family; Region: AsnC_trans_reg; pfam01037
703352004524	Transcriptional regulators [Transcription]; Region: MarR; COG1846
703352004525	MarR family; Region: MarR_2; pfam12802
703352004526	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
703352004527	putative substrate translocation pore; other site
703352004528	Major Facilitator Superfamily; Region: MFS_1; pfam07690
703352004529	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG5459
703352004530	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5345
703352004531	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
703352004532	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
703352004533	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352004534	dimer interface [polypeptide binding]; other site
703352004535	conserved gate region; other site
703352004536	putative PBP binding loops; other site
703352004537	ABC-ATPase subunit interface; other site
703352004538	choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415
703352004539	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
703352004540	Walker A/P-loop; other site
703352004541	ATP binding site [chemical binding]; other site
703352004542	Q-loop/lid; other site
703352004543	ABC transporter signature motif; other site
703352004544	Walker B; other site
703352004545	D-loop; other site
703352004546	H-loop/switch region; other site
703352004547	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
703352004548	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
703352004549	Walker A/P-loop; other site
703352004550	ATP binding site [chemical binding]; other site
703352004551	Q-loop/lid; other site
703352004552	ABC transporter signature motif; other site
703352004553	Walker B; other site
703352004554	D-loop; other site
703352004555	H-loop/switch region; other site
703352004556	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
703352004557	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
703352004558	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
703352004559	Walker A/P-loop; other site
703352004560	ATP binding site [chemical binding]; other site
703352004561	Q-loop/lid; other site
703352004562	ABC transporter signature motif; other site
703352004563	Walker B; other site
703352004564	D-loop; other site
703352004565	H-loop/switch region; other site
703352004566	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
703352004567	dipeptide transporter; Provisional; Region: PRK10913
703352004568	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
703352004569	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352004570	dimer interface [polypeptide binding]; other site
703352004571	conserved gate region; other site
703352004572	putative PBP binding loops; other site
703352004573	ABC-ATPase subunit interface; other site
703352004574	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
703352004575	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352004576	dimer interface [polypeptide binding]; other site
703352004577	conserved gate region; other site
703352004578	putative PBP binding loops; other site
703352004579	ABC-ATPase subunit interface; other site
703352004580	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
703352004581	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
703352004582	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
703352004583	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
703352004584	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
703352004585	putative DNA binding site [nucleotide binding]; other site
703352004586	putative Zn2+ binding site [ion binding]; other site
703352004587	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
703352004588	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
703352004589	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
703352004590	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
703352004591	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
703352004592	Ligand Binding Site [chemical binding]; other site
703352004593	Protein of unknown function (DUF1153); Region: DUF1153; pfam06627
703352004594	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
703352004595	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5400
703352004596	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5385
703352004597	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
703352004598	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
703352004599	active site
703352004600	phosphorylation site [posttranslational modification]
703352004601	intermolecular recognition site; other site
703352004602	dimerization interface [polypeptide binding]; other site
703352004603	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
703352004604	DNA binding site [nucleotide binding]
703352004605	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
703352004606	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
703352004607	inhibitor-cofactor binding pocket; inhibition site
703352004608	pyridoxal 5'-phosphate binding site [chemical binding]; other site
703352004609	catalytic residue [active]
703352004610	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
703352004611	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
703352004612	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
703352004613	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
703352004614	PAS domain; Region: PAS_8; pfam13188
703352004615	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
703352004616	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
703352004617	putative active site [active]
703352004618	heme pocket [chemical binding]; other site
703352004619	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
703352004620	dimer interface [polypeptide binding]; other site
703352004621	phosphorylation site [posttranslational modification]
703352004622	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
703352004623	ATP binding site [chemical binding]; other site
703352004624	Mg2+ binding site [ion binding]; other site
703352004625	G-X-G motif; other site
703352004626	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
703352004627	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
703352004628	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
703352004629	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352004630	dimer interface [polypeptide binding]; other site
703352004631	conserved gate region; other site
703352004632	putative PBP binding loops; other site
703352004633	ABC-ATPase subunit interface; other site
703352004634	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352004635	dimer interface [polypeptide binding]; other site
703352004636	conserved gate region; other site
703352004637	putative PBP binding loops; other site
703352004638	ABC-ATPase subunit interface; other site
703352004639	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
703352004640	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
703352004641	Walker A/P-loop; other site
703352004642	ATP binding site [chemical binding]; other site
703352004643	Q-loop/lid; other site
703352004644	ABC transporter signature motif; other site
703352004645	Walker B; other site
703352004646	D-loop; other site
703352004647	H-loop/switch region; other site
703352004648	TOBE domain; Region: TOBE_2; pfam08402
703352004649	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
703352004650	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
703352004651	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
703352004652	Domain of unknown function (DUF955); Region: DUF955; pfam06114
703352004653	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
703352004654	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
703352004655	non-specific DNA binding site [nucleotide binding]; other site
703352004656	salt bridge; other site
703352004657	sequence-specific DNA binding site [nucleotide binding]; other site
703352004658	isocitrate lyase; Provisional; Region: PRK15063
703352004659	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
703352004660	tetramer interface [polypeptide binding]; other site
703352004661	active site
703352004662	Mg2+/Mn2+ binding site [ion binding]; other site
703352004663	7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113
703352004664	7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365
703352004665	NAD binding site [chemical binding]; other site
703352004666	substrate binding site [chemical binding]; other site
703352004667	homotetramer interface [polypeptide binding]; other site
703352004668	homodimer interface [polypeptide binding]; other site
703352004669	active site
703352004670	7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113
703352004671	7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365
703352004672	NAD binding site [chemical binding]; other site
703352004673	substrate binding site [chemical binding]; other site
703352004674	homotetramer interface [polypeptide binding]; other site
703352004675	homodimer interface [polypeptide binding]; other site
703352004676	active site
703352004677	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
703352004678	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
703352004679	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
703352004680	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
703352004681	active site
703352004682	nucleophile elbow; other site
703352004683	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
703352004684	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
703352004685	DAK2 domain; Region: Dak2; cl03685
703352004686	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
703352004687	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
703352004688	DNA binding residues [nucleotide binding]
703352004689	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
703352004690	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
703352004691	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
703352004692	DAK2 domain; Region: Dak2; pfam02734
703352004693	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
703352004694	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
703352004695	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
703352004696	classical (c) SDRs; Region: SDR_c; cd05233
703352004697	NAD(P) binding site [chemical binding]; other site
703352004698	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
703352004699	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
703352004700	putative ligand binding site [chemical binding]; other site
703352004701	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
703352004702	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
703352004703	TM-ABC transporter signature motif; other site
703352004704	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
703352004705	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
703352004706	Walker A/P-loop; other site
703352004707	ATP binding site [chemical binding]; other site
703352004708	Q-loop/lid; other site
703352004709	ABC transporter signature motif; other site
703352004710	Walker B; other site
703352004711	D-loop; other site
703352004712	H-loop/switch region; other site
703352004713	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
703352004714	Uncharacterized conserved protein [Function unknown]; Region: COG5591
703352004715	choline dehydrogenase; Validated; Region: PRK02106
703352004716	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
703352004717	potential protein location (hypothetical protein BM590_A1629 [Brucella melitensis M5-90]) that overlaps RNA (16S ribosomal RNA)
703352004718	Transcriptional regulator [Transcription]; Region: IclR; COG1414
703352004719	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
703352004720	Bacterial transcriptional regulator; Region: IclR; pfam01614
703352004721	succinic semialdehyde dehydrogenase; Region: PLN02278
703352004722	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
703352004723	tetramerization interface [polypeptide binding]; other site
703352004724	NAD(P) binding site [chemical binding]; other site
703352004725	catalytic residues [active]
703352004726	Predicted membrane protein [Function unknown]; Region: COG1238
703352004727	Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495
703352004728	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
703352004729	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
703352004730	active site
703352004731	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
703352004732	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
703352004733	helix-hairpin-helix signature motif; other site
703352004734	substrate binding pocket [chemical binding]; other site
703352004735	active site
703352004736	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
703352004737	Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008
703352004738	active site
703352004739	HIGH motif; other site
703352004740	nucleotide binding site [chemical binding]; other site
703352004741	active site
703352004742	KMSKS motif; other site
703352004743	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
703352004744	active site
703352004745	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
703352004746	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
703352004747	Coenzyme A binding pocket [chemical binding]; other site
703352004748	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
703352004749	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
703352004750	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
703352004751	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
703352004752	DNA binding residues [nucleotide binding]
703352004753	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
703352004754	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
703352004755	RNA binding surface [nucleotide binding]; other site
703352004756	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
703352004757	active site
703352004758	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
703352004759	metal binding site 2 [ion binding]; metal-binding site
703352004760	putative DNA binding helix; other site
703352004761	metal binding site 1 [ion binding]; metal-binding site
703352004762	dimer interface [polypeptide binding]; other site
703352004763	structural Zn2+ binding site [ion binding]; other site
703352004764	PAS fold; Region: PAS_4; pfam08448
703352004765	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
703352004766	HWE histidine kinase; Region: HWE_HK; pfam07536
703352004767	two-component response regulator; Provisional; Region: PRK09191
703352004768	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
703352004769	active site
703352004770	phosphorylation site [posttranslational modification]
703352004771	intermolecular recognition site; other site
703352004772	dimerization interface [polypeptide binding]; other site
703352004773	RNA polymerase sigma factor; Provisional; Region: PRK12516
703352004774	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
703352004775	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
703352004776	DNA binding residues [nucleotide binding]
703352004777	CHASE3 domain; Region: CHASE3; pfam05227
703352004778	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
703352004779	Histidine kinase; Region: HisKA_2; pfam07568
703352004780	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
703352004781	ATP binding site [chemical binding]; other site
703352004782	Mg2+ binding site [ion binding]; other site
703352004783	G-X-G motif; other site
703352004784	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
703352004785	PRC-barrel domain; Region: PRC; pfam05239
703352004786	PRC-barrel domain; Region: PRC; pfam05239
703352004787	tonB-system energizer ExbB; Region: exbB; TIGR02797
703352004788	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
703352004789	TonB system transport protein ExbD, group 1; Region: ExbD_1; TIGR02803
703352004790	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
703352004791	TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352
703352004792	Predicted periplasmic protein [Function unknown]; Region: COG3698
703352004793	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
703352004794	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
703352004795	FtsX-like permease family; Region: FtsX; pfam02687
703352004796	potential frameshift: common BLAST hit: gi|256370083|ref|YP_003107594.1| Macrolide export ATP-binding/permease protein macB
703352004797	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
703352004798	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
703352004799	Walker A/P-loop; other site
703352004800	ATP binding site [chemical binding]; other site
703352004801	ABC transporter; Region: ABC_tran; pfam00005
703352004802	Q-loop/lid; other site
703352004803	ABC transporter signature motif; other site
703352004804	Walker B; other site
703352004805	D-loop; other site
703352004806	macrolide transporter subunit MacA; Provisional; Region: PRK11578
703352004807	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
703352004808	HlyD family secretion protein; Region: HlyD_3; pfam13437
703352004809	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
703352004810	trimer interface [polypeptide binding]; other site
703352004811	active site
703352004812	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
703352004813	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
703352004814	dimerization interface [polypeptide binding]; other site
703352004815	putative DNA binding site [nucleotide binding]; other site
703352004816	putative Zn2+ binding site [ion binding]; other site
703352004817	AsnC family; Region: AsnC_trans_reg; pfam01037
703352004818	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
703352004819	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
703352004820	putative dimer interface [polypeptide binding]; other site
703352004821	putative active site [active]
703352004822	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
703352004823	diiron binding motif [ion binding]; other site
703352004824	Uncharacterized conserved protein [Function unknown]; Region: COG1633
703352004825	CCC1-related protein family; Region: CCC1_like_1; cd02437
703352004826	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
703352004827	metabolite-proton symporter; Region: 2A0106; TIGR00883
703352004828	putative substrate translocation pore; other site
703352004829	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
703352004830	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
703352004831	GDP-binding site [chemical binding]; other site
703352004832	ACT binding site; other site
703352004833	IMP binding site; other site
703352004834	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
703352004835	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
703352004836	Coenzyme A binding pocket [chemical binding]; other site
703352004837	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
703352004838	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
703352004839	ligand binding site [chemical binding]; other site
703352004840	NAD binding site [chemical binding]; other site
703352004841	dimerization interface [polypeptide binding]; other site
703352004842	catalytic site [active]
703352004843	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
703352004844	putative L-serine binding site [chemical binding]; other site
703352004845	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
703352004846	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
703352004847	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
703352004848	catalytic residue [active]
703352004849	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
703352004850	Sodium Bile acid symporter family; Region: SBF; pfam01758
703352004851	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
703352004852	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315
703352004853	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
703352004854	active site
703352004855	substrate binding site [chemical binding]; other site
703352004856	metal binding site [ion binding]; metal-binding site
703352004857	FtsH Extracellular; Region: FtsH_ext; pfam06480
703352004858	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
703352004859	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
703352004860	Walker A motif; other site
703352004861	ATP binding site [chemical binding]; other site
703352004862	Walker B motif; other site
703352004863	arginine finger; other site
703352004864	Peptidase family M41; Region: Peptidase_M41; pfam01434
703352004865	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
703352004866	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
703352004867	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
703352004868	Tetratricopeptide repeat; Region: TPR_6; pfam13174
703352004869	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
703352004870	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
703352004871	ligand binding site [chemical binding]; other site
703352004872	translocation protein TolB; Provisional; Region: tolB; PRK05137
703352004873	TolB amino-terminal domain; Region: TolB_N; pfam04052
703352004874	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
703352004875	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
703352004876	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
703352004877	TolR protein; Region: tolR; TIGR02801
703352004878	TolQ protein; Region: tolQ; TIGR02796
703352004879	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
703352004880	active site
703352004881	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
703352004882	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
703352004883	Walker A motif; other site
703352004884	ATP binding site [chemical binding]; other site
703352004885	Walker B motif; other site
703352004886	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
703352004887	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
703352004888	RuvA N terminal domain; Region: RuvA_N; pfam01330
703352004889	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
703352004890	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
703352004891	active site
703352004892	putative DNA-binding cleft [nucleotide binding]; other site
703352004893	dimer interface [polypeptide binding]; other site
703352004894	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5317
703352004895	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4645
703352004896	Acyltransferase family; Region: Acyl_transf_3; pfam01757
703352004897	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
703352004898	active site
703352004899	thiamine phosphate binding site [chemical binding]; other site
703352004900	pyrophosphate binding site [ion binding]; other site
703352004901	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
703352004902	Sel1-like repeats; Region: SEL1; smart00671
703352004903	Sel1-like repeats; Region: SEL1; smart00671
703352004904	elongation factor P; Validated; Region: PRK00529
703352004905	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
703352004906	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
703352004907	RNA binding site [nucleotide binding]; other site
703352004908	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
703352004909	RNA binding site [nucleotide binding]; other site
703352004910	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
703352004911	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
703352004912	active site
703352004913	dimerization interface [polypeptide binding]; other site
703352004914	hypothetical protein; Validated; Region: PRK09039
703352004915	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
703352004916	ligand binding site [chemical binding]; other site
703352004917	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
703352004918	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
703352004919	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
703352004920	Walker A/P-loop; other site
703352004921	ATP binding site [chemical binding]; other site
703352004922	Q-loop/lid; other site
703352004923	ABC transporter signature motif; other site
703352004924	Walker B; other site
703352004925	D-loop; other site
703352004926	H-loop/switch region; other site
703352004927	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528
703352004928	hypothetical protein; Validated; Region: PRK00110
703352004929	Transcriptional regulators [Transcription]; Region: GntR; COG1802
703352004930	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
703352004931	DNA-binding site [nucleotide binding]; DNA binding site
703352004932	FCD domain; Region: FCD; pfam07729
703352004933	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
703352004934	Uncharacterized conserved protein [Function unknown]; Region: COG3543
703352004935	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
703352004936	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
703352004937	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
703352004938	putative active site [active]
703352004939	metal binding site [ion binding]; metal-binding site
703352004940	homodimer binding site [polypeptide binding]; other site
703352004941	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
703352004942	Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division,    chromosome partitioning]; Region: zapA; COG3027
703352004943	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
703352004944	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
703352004945	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
703352004946	TPP-binding site [chemical binding]; other site
703352004947	dimer interface [polypeptide binding]; other site
703352004948	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
703352004949	PYR/PP interface [polypeptide binding]; other site
703352004950	dimer interface [polypeptide binding]; other site
703352004951	TPP binding site [chemical binding]; other site
703352004952	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
703352004953	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
703352004954	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
703352004955	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
703352004956	Phosphoglycerate kinase; Region: PGK; pfam00162
703352004957	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
703352004958	substrate binding site [chemical binding]; other site
703352004959	hinge regions; other site
703352004960	ADP binding site [chemical binding]; other site
703352004961	catalytic site [active]
703352004962	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
703352004963	Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967
703352004964	acyl-activating enzyme (AAE) consensus motif; other site
703352004965	putative AMP binding site [chemical binding]; other site
703352004966	putative active site [active]
703352004967	putative CoA binding site [chemical binding]; other site
703352004968	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
703352004969	Predicted transcriptional regulator [Transcription]; Region: COG2378
703352004970	HTH domain; Region: HTH_11; pfam08279
703352004971	WYL domain; Region: WYL; pfam13280
703352004972	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
703352004973	CoenzymeA binding site [chemical binding]; other site
703352004974	subunit interaction site [polypeptide binding]; other site
703352004975	PHB binding site; other site
703352004976	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
703352004977	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820
703352004978	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
703352004979	NAD(P) binding site [chemical binding]; other site
703352004980	Uncharacterized small protein containing a coiled-coil domain [Function unknown]; Region: COG5509
703352004981	putative MFS family transporter protein; Provisional; Region: PRK03633
703352004982	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
703352004983	putative substrate translocation pore; other site
703352004984	Uncharacterized small protein [Function unknown]; Region: COG5570
703352004985	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
703352004986	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
703352004987	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
703352004988	NAD binding site [chemical binding]; other site
703352004989	ATP-grasp domain; Region: ATP-grasp; pfam02222
703352004990	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
703352004991	TPR repeat; Region: TPR_11; pfam13414
703352004992	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
703352004993	TPR motif; other site
703352004994	binding surface
703352004995	pyruvate kinase; Provisional; Region: PRK06247
703352004996	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
703352004997	domain interfaces; other site
703352004998	active site
703352004999	Predicted integral membrane protein [Function unknown]; Region: COG5480
703352005000	Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931
703352005001	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3750
703352005002	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
703352005003	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
703352005004	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
703352005005	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
703352005006	Thiamine pyrophosphokinase; Region: TPK; cd07995
703352005007	active site
703352005008	dimerization interface [polypeptide binding]; other site
703352005009	thiamine binding site [chemical binding]; other site
703352005010	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
703352005011	thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205
703352005012	thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433
703352005013	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352005014	dimer interface [polypeptide binding]; other site
703352005015	conserved gate region; other site
703352005016	putative PBP binding loops; other site
703352005017	ABC-ATPase subunit interface; other site
703352005018	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352005019	dimer interface [polypeptide binding]; other site
703352005020	conserved gate region; other site
703352005021	putative PBP binding loops; other site
703352005022	ABC-ATPase subunit interface; other site
703352005023	ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840
703352005024	ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298
703352005025	Walker A/P-loop; other site
703352005026	ATP binding site [chemical binding]; other site
703352005027	Q-loop/lid; other site
703352005028	ABC transporter signature motif; other site
703352005029	Walker B; other site
703352005030	D-loop; other site
703352005031	H-loop/switch region; other site
703352005032	Putative Zn-dependent protease [General function prediction only]; Region: COG4784
703352005033	Peptidase family M48; Region: Peptidase_M48; pfam01435
703352005034	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
703352005035	MOSC domain; Region: MOSC; pfam03473
703352005036	3-alpha domain; Region: 3-alpha; pfam03475
703352005037	RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500
703352005038	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
703352005039	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
703352005040	DNA binding residues [nucleotide binding]
703352005041	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
703352005042	Ferredoxin [Energy production and conversion]; Region: COG1146
703352005043	4Fe-4S binding domain; Region: Fer4; pfam00037
703352005044	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
703352005045	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
703352005046	RNA binding surface [nucleotide binding]; other site
703352005047	DEAD/DEAH box helicase; Region: DEAD; pfam00270
703352005048	ATP binding site [chemical binding]; other site
703352005049	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
703352005050	putative Mg++ binding site [ion binding]; other site
703352005051	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
703352005052	nucleotide binding region [chemical binding]; other site
703352005053	ATP-binding site [chemical binding]; other site
703352005054	putative acyltransferase; Provisional; Region: PRK05790
703352005055	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
703352005056	dimer interface [polypeptide binding]; other site
703352005057	active site
703352005058	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
703352005059	Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333
703352005060	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
703352005061	Transglycosylase; Region: Transgly; pfam00912
703352005062	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
703352005063	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
703352005064	substrate binding pocket [chemical binding]; other site
703352005065	chain length determination region; other site
703352005066	substrate-Mg2+ binding site; other site
703352005067	catalytic residues [active]
703352005068	aspartate-rich region 1; other site
703352005069	active site lid residues [active]
703352005070	aspartate-rich region 2; other site
703352005071	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
703352005072	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
703352005073	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
703352005074	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
703352005075	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
703352005076	NAD(P) binding site [chemical binding]; other site
703352005077	active site
703352005078	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
703352005079	Major Facilitator Superfamily; Region: MFS_1; pfam07690
703352005080	putative substrate translocation pore; other site
703352005081	pyruvate carboxylase; Reviewed; Region: PRK12999
703352005082	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
703352005083	ATP-grasp domain; Region: ATP-grasp_4; cl17255
703352005084	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
703352005085	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
703352005086	active site
703352005087	catalytic residues [active]
703352005088	metal binding site [ion binding]; metal-binding site
703352005089	homodimer binding site [polypeptide binding]; other site
703352005090	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
703352005091	carboxyltransferase (CT) interaction site; other site
703352005092	biotinylation site [posttranslational modification]; other site
703352005093	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
703352005094	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
703352005095	dimerization interface [polypeptide binding]; other site
703352005096	ligand binding site [chemical binding]; other site
703352005097	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
703352005098	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
703352005099	dimerization interface [polypeptide binding]; other site
703352005100	ligand binding site [chemical binding]; other site
703352005101	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
703352005102	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
703352005103	Walker A/P-loop; other site
703352005104	ATP binding site [chemical binding]; other site
703352005105	Q-loop/lid; other site
703352005106	ABC transporter signature motif; other site
703352005107	Walker B; other site
703352005108	D-loop; other site
703352005109	H-loop/switch region; other site
703352005110	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
703352005111	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
703352005112	Walker A/P-loop; other site
703352005113	ATP binding site [chemical binding]; other site
703352005114	Q-loop/lid; other site
703352005115	ABC transporter signature motif; other site
703352005116	Walker B; other site
703352005117	D-loop; other site
703352005118	H-loop/switch region; other site
703352005119	Uncharacterized conserved protein [Function unknown]; Region: COG3743
703352005120	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
703352005121	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
703352005122	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
703352005123	TM-ABC transporter signature motif; other site
703352005124	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
703352005125	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
703352005126	TM-ABC transporter signature motif; other site
703352005127	Proline racemase [Amino acid transport and metabolism]; Region: COG3938
703352005128	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
703352005129	potential frameshift: common BLAST hit: gi|340791388|ref|YP_004756853.1| D-amino acid dehydrogenase, small subunit
703352005130	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
703352005131	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
703352005132	FAD dependent oxidoreductase; Region: DAO; pfam01266
703352005133	Transcriptional regulators [Transcription]; Region: GntR; COG1802
703352005134	FCD domain; Region: FCD; pfam07729
703352005135	MarR family; Region: MarR; pfam01047
703352005136	transcriptional regulator SlyA; Provisional; Region: PRK03573
703352005137	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
703352005138	F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]; Region: AtpC; COG0355
703352005139	gamma subunit interface [polypeptide binding]; other site
703352005140	epsilon subunit interface [polypeptide binding]; other site
703352005141	LBP interface [polypeptide binding]; other site
703352005142	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
703352005143	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
703352005144	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
703352005145	alpha subunit interaction interface [polypeptide binding]; other site
703352005146	Walker A motif; other site
703352005147	ATP binding site [chemical binding]; other site
703352005148	Walker B motif; other site
703352005149	inhibitor binding site; inhibition site
703352005150	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
703352005151	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
703352005152	core domain interface [polypeptide binding]; other site
703352005153	delta subunit interface [polypeptide binding]; other site
703352005154	epsilon subunit interface [polypeptide binding]; other site
703352005155	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
703352005156	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
703352005157	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
703352005158	beta subunit interaction interface [polypeptide binding]; other site
703352005159	Walker A motif; other site
703352005160	ATP binding site [chemical binding]; other site
703352005161	Walker B motif; other site
703352005162	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
703352005163	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
703352005164	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
703352005165	primosome assembly protein PriA; Validated; Region: PRK05580
703352005166	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
703352005167	ATP binding site [chemical binding]; other site
703352005168	putative Mg++ binding site [ion binding]; other site
703352005169	helicase superfamily c-terminal domain; Region: HELICc; smart00490
703352005170	nucleotide binding region [chemical binding]; other site
703352005171	ATP-binding site [chemical binding]; other site
703352005172	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
703352005173	active site
703352005174	intersubunit interactions; other site
703352005175	catalytic residue [active]
703352005176	Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5468
703352005177	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
703352005178	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
703352005179	HIGH motif; other site
703352005180	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
703352005181	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
703352005182	active site
703352005183	KMSKS motif; other site
703352005184	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
703352005185	tRNA binding surface [nucleotide binding]; other site
703352005186	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
703352005187	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
703352005188	catalytic residue [active]
703352005189	Predicted membrane protein [Function unknown]; Region: COG1289
703352005190	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
703352005191	Usg protein, probable subunit of phosphoribosylanthranilate isomerase [Amino acid transport and metabolism]; Region: COG5425
703352005192	acetyl-CoA synthetase; Provisional; Region: PRK00174
703352005193	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
703352005194	active site
703352005195	CoA binding site [chemical binding]; other site
703352005196	acyl-activating enzyme (AAE) consensus motif; other site
703352005197	AMP binding site [chemical binding]; other site
703352005198	acetate binding site [chemical binding]; other site
703352005199	Uncharacterized conserved small protein [Function unknown]; Region: COG5508
703352005200	Protein of unknown function (DUF1674); Region: DUF1674; pfam07896
703352005201	heat shock protein HtpX; Provisional; Region: PRK01345
703352005202	NusB family; Region: NusB; pfam01029
703352005203	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
703352005204	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
703352005205	S-adenosylmethionine binding site [chemical binding]; other site
703352005206	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5360
703352005207	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
703352005208	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
703352005209	purine monophosphate binding site [chemical binding]; other site
703352005210	dimer interface [polypeptide binding]; other site
703352005211	putative catalytic residues [active]
703352005212	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
703352005213	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
703352005214	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
703352005215	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
703352005216	Predicted membrane protein [Function unknown]; Region: COG3762
703352005217	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
703352005218	Repair protein; Region: Repair_PSII; pfam04536
703352005219	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
703352005220	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
703352005221	chorismate mutase; Provisional; Region: PRK09239
703352005222	signal recognition particle protein; Provisional; Region: PRK10867
703352005223	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
703352005224	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
703352005225	P loop; other site
703352005226	GTP binding site [chemical binding]; other site
703352005227	Signal peptide binding domain; Region: SRP_SPB; pfam02978
703352005228	lytic murein transglycosylase; Region: MltB_2; TIGR02283
703352005229	murein hydrolase B; Provisional; Region: PRK10760; cl17906
703352005230	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
703352005231	active site clefts [active]
703352005232	zinc binding site [ion binding]; other site
703352005233	dimer interface [polypeptide binding]; other site
703352005234	pyridoxamine kinase; Validated; Region: PRK05756
703352005235	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
703352005236	dimer interface [polypeptide binding]; other site
703352005237	pyridoxal binding site [chemical binding]; other site
703352005238	ATP binding site [chemical binding]; other site
703352005239	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
703352005240	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
703352005241	tetrameric interface [polypeptide binding]; other site
703352005242	NAD binding site [chemical binding]; other site
703352005243	catalytic residues [active]
703352005244	Transcriptional regulator [Transcription]; Region: LysR; COG0583
703352005245	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
703352005246	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
703352005247	dimerization interface [polypeptide binding]; other site
703352005248	Predicted membrane protein [Function unknown]; Region: COG3619
703352005249	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
703352005250	putative active site [active]
703352005251	Ap4A binding site [chemical binding]; other site
703352005252	nudix motif; other site
703352005253	putative metal binding site [ion binding]; other site
703352005254	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
703352005255	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
703352005256	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
703352005257	protein binding site [polypeptide binding]; other site
703352005258	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
703352005259	Catalytic dyad [active]
703352005260	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
703352005261	Peptidase family M23; Region: Peptidase_M23; pfam01551
703352005262	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
703352005263	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
703352005264	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
703352005265	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
703352005266	active site
703352005267	(T/H)XGH motif; other site
703352005268	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
703352005269	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
703352005270	putative catalytic cysteine [active]
703352005271	gamma-glutamyl kinase; Provisional; Region: PRK05429
703352005272	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
703352005273	nucleotide binding site [chemical binding]; other site
703352005274	homotetrameric interface [polypeptide binding]; other site
703352005275	putative phosphate binding site [ion binding]; other site
703352005276	putative allosteric binding site; other site
703352005277	PUA domain; Region: PUA; pfam01472
703352005278	GTPase CgtA; Reviewed; Region: obgE; PRK12299
703352005279	GTP1/OBG; Region: GTP1_OBG; pfam01018
703352005280	Obg GTPase; Region: Obg; cd01898
703352005281	G1 box; other site
703352005282	GTP/Mg2+ binding site [chemical binding]; other site
703352005283	Switch I region; other site
703352005284	G2 box; other site
703352005285	G3 box; other site
703352005286	Switch II region; other site
703352005287	G4 box; other site
703352005288	G5 box; other site
703352005289	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
703352005290	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
703352005291	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
703352005292	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
703352005293	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
703352005294	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
703352005295	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
703352005296	Integrase core domain; Region: rve; pfam00665
703352005297	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
703352005298	non-specific DNA binding site [nucleotide binding]; other site
703352005299	salt bridge; other site
703352005300	sequence-specific DNA binding site [nucleotide binding]; other site
703352005301	Cupin domain; Region: Cupin_2; cl17218
703352005302	Methyltransferase domain; Region: Methyltransf_31; pfam13847
703352005303	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
703352005304	S-adenosylmethionine binding site [chemical binding]; other site
703352005305	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
703352005306	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
703352005307	Integrase core domain; Region: rve; pfam00665
703352005308	potential protein location (hypothetical protein BM590_A1850 [Brucella melitensis M5-90]) that overlaps RNA (16S ribosomal RNA)
703352005309	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
703352005310	Peptidase family M23; Region: Peptidase_M23; pfam01551
703352005311	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
703352005312	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
703352005313	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
703352005314	Clp amino terminal domain; Region: Clp_N; pfam02861
703352005315	Clp amino terminal domain; Region: Clp_N; pfam02861
703352005316	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
703352005317	Walker A motif; other site
703352005318	ATP binding site [chemical binding]; other site
703352005319	Walker B motif; other site
703352005320	arginine finger; other site
703352005321	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
703352005322	Walker A motif; other site
703352005323	ATP binding site [chemical binding]; other site
703352005324	Walker B motif; other site
703352005325	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
703352005326	Domain of unknown function (DUF4167); Region: DUF4167; pfam13763
703352005327	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
703352005328	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
703352005329	S-adenosylmethionine binding site [chemical binding]; other site
703352005330	peptide chain release factor 1; Validated; Region: prfA; PRK00591
703352005331	This domain is found in peptide chain release factors; Region: PCRF; smart00937
703352005332	RF-1 domain; Region: RF-1; pfam00472
703352005333	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
703352005334	GAF domain; Region: GAF; pfam01590
703352005335	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
703352005336	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
703352005337	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
703352005338	aspartate kinase; Reviewed; Region: PRK06635
703352005339	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
703352005340	putative nucleotide binding site [chemical binding]; other site
703352005341	putative catalytic residues [active]
703352005342	putative Mg ion binding site [ion binding]; other site
703352005343	putative aspartate binding site [chemical binding]; other site
703352005344	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
703352005345	putative allosteric regulatory site; other site
703352005346	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
703352005347	putative allosteric regulatory residue; other site
703352005348	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
703352005349	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
703352005350	S-adenosylmethionine binding site [chemical binding]; other site
703352005351	EamA-like transporter family; Region: EamA; pfam00892
703352005352	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5319
703352005353	Predicted amidohydrolase [General function prediction only]; Region: COG0388
703352005354	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
703352005355	putative active site [active]
703352005356	catalytic triad [active]
703352005357	dimer interface [polypeptide binding]; other site
703352005358	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
703352005359	GSH binding site [chemical binding]; other site
703352005360	catalytic residues [active]
703352005361	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
703352005362	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
703352005363	active site
703352005364	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
703352005365	Methyltransferase domain; Region: Methyltransf_11; pfam08241
703352005366	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
703352005367	putative substrate translocation pore; other site
703352005368	tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313
703352005369	putative metal binding site [ion binding]; other site
703352005370	Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898
703352005371	HemY protein N-terminus; Region: HemY_N; pfam07219
703352005372	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223
703352005373	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
703352005374	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
703352005375	active site
703352005376	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
703352005377	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
703352005378	domain interfaces; other site
703352005379	active site
703352005380	UGMP family protein; Validated; Region: PRK09604
703352005381	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
703352005382	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
703352005383	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
703352005384	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
703352005385	YCII-related domain; Region: YCII; cl00999
703352005386	Uncharacterized conserved protein [Function unknown]; Region: COG2947
703352005387	Predicted methyltransferase [General function prediction only]; Region: COG3897
703352005388	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
703352005389	S-adenosylmethionine binding site [chemical binding]; other site
703352005390	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
703352005391	EamA-like transporter family; Region: EamA; pfam00892
703352005392	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
703352005393	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
703352005394	DNA-binding site [nucleotide binding]; DNA binding site
703352005395	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
703352005396	pyridoxal 5'-phosphate binding site [chemical binding]; other site
703352005397	homodimer interface [polypeptide binding]; other site
703352005398	catalytic residue [active]
703352005399	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
703352005400	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
703352005401	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
703352005402	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
703352005403	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
703352005404	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
703352005405	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
703352005406	active site
703352005407	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
703352005408	catalytic triad [active]
703352005409	dimer interface [polypeptide binding]; other site
703352005410	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333
703352005411	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
703352005412	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
703352005413	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
703352005414	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
703352005415	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
703352005416	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
703352005417	L-aspartate oxidase; Provisional; Region: PRK06175
703352005418	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
703352005419	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495
703352005420	putative SdhC subunit interface [polypeptide binding]; other site
703352005421	putative proximal heme binding site [chemical binding]; other site
703352005422	putative Iron-sulfur protein interface [polypeptide binding]; other site
703352005423	putative proximal quinone binding site; other site
703352005424	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
703352005425	Iron-sulfur protein interface; other site
703352005426	proximal quinone binding site [chemical binding]; other site
703352005427	SdhD (CybS) interface [polypeptide binding]; other site
703352005428	proximal heme binding site [chemical binding]; other site
703352005429	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
703352005430	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
703352005431	Coenzyme A binding pocket [chemical binding]; other site
703352005432	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
703352005433	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
703352005434	substrate binding site [chemical binding]; other site
703352005435	ligand binding site [chemical binding]; other site
703352005436	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
703352005437	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
703352005438	Cytosine/uracil/thiamine/allantoin permeases [Nucleotide transport and metabolism / Coenzyme metabolism]; Region: FUI1; COG1953
703352005439	Na binding site [ion binding]; other site
703352005440	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
703352005441	NIPSNAP; Region: NIPSNAP; pfam07978
703352005442	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
703352005443	dimerization interface [polypeptide binding]; other site
703352005444	putative DNA binding site [nucleotide binding]; other site
703352005445	putative Zn2+ binding site [ion binding]; other site
703352005446	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
703352005447	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
703352005448	RimM N-terminal domain; Region: RimM; pfam01782
703352005449	PRC-barrel domain; Region: PRC; pfam05239
703352005450	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
703352005451	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
703352005452	active site
703352005453	DNA binding site [nucleotide binding]
703352005454	Int/Topo IB signature motif; other site
703352005455	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735
703352005456	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
703352005457	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
703352005458	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
703352005459	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
703352005460	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
703352005461	Predicted membrane protein [Function unknown]; Region: COG3686
703352005462	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
703352005463	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
703352005464	E3 interaction surface; other site
703352005465	lipoyl attachment site [posttranslational modification]; other site
703352005466	e3 binding domain; Region: E3_binding; pfam02817
703352005467	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
703352005468	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
703352005469	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
703352005470	TPP-binding site [chemical binding]; other site
703352005471	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
703352005472	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
703352005473	CoA binding domain; Region: CoA_binding; smart00881
703352005474	CoA-ligase; Region: Ligase_CoA; pfam00549
703352005475	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
703352005476	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
703352005477	CoA-ligase; Region: Ligase_CoA; pfam00549
703352005478	malate dehydrogenase; Reviewed; Region: PRK06223
703352005479	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
703352005480	NAD(P) binding site [chemical binding]; other site
703352005481	dimer interface [polypeptide binding]; other site
703352005482	tetramer (dimer of dimers) interface [polypeptide binding]; other site
703352005483	substrate binding site [chemical binding]; other site
703352005484	Predicted ATPase [General function prediction only]; Region: COG1485
703352005485	Protease inhibitor Inh; Region: Inh; pfam02974
703352005486	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
703352005487	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
703352005488	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
703352005489	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
703352005490	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
703352005491	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
703352005492	FeS/SAM binding site; other site
703352005493	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
703352005494	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
703352005495	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
703352005496	intracellular septation protein A; Reviewed; Region: PRK00259
703352005497	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
703352005498	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
703352005499	active site
703352005500	8-oxo-dGMP binding site [chemical binding]; other site
703352005501	nudix motif; other site
703352005502	metal binding site [ion binding]; metal-binding site
703352005503	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
703352005504	Coenzyme A binding pocket [chemical binding]; other site
703352005505	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
703352005506	heterotetramer interface [polypeptide binding]; other site
703352005507	active site pocket [active]
703352005508	cleavage site
703352005509	peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002
703352005510	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
703352005511	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
703352005512	DEAD/DEAH box helicase; Region: DEAD; pfam00270
703352005513	ATP binding site [chemical binding]; other site
703352005514	putative Mg++ binding site [ion binding]; other site
703352005515	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
703352005516	SEC-C motif; Region: SEC-C; pfam02810
703352005517	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
703352005518	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
703352005519	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
703352005520	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
703352005521	Sulfatase; Region: Sulfatase; pfam00884
703352005522	Transcriptional regulator [Transcription]; Region: LysR; COG0583
703352005523	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
703352005524	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
703352005525	dimerization interface [polypeptide binding]; other site
703352005526	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
703352005527	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
703352005528	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
703352005529	membrane-bound complex binding site; other site
703352005530	hinge residues; other site
703352005531	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
703352005532	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352005533	dimer interface [polypeptide binding]; other site
703352005534	conserved gate region; other site
703352005535	putative PBP binding loops; other site
703352005536	ABC-ATPase subunit interface; other site
703352005537	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
703352005538	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352005539	dimer interface [polypeptide binding]; other site
703352005540	conserved gate region; other site
703352005541	putative PBP binding loops; other site
703352005542	ABC-ATPase subunit interface; other site
703352005543	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
703352005544	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
703352005545	Walker A/P-loop; other site
703352005546	ATP binding site [chemical binding]; other site
703352005547	Q-loop/lid; other site
703352005548	ABC transporter signature motif; other site
703352005549	Walker B; other site
703352005550	D-loop; other site
703352005551	H-loop/switch region; other site
703352005552	agmatinase; Region: agmatinase; TIGR01230
703352005553	Agmatinase and related proteins; Region: Agmatinase_like_1; cd11589
703352005554	oligomer interface [polypeptide binding]; other site
703352005555	active site
703352005556	Mn binding site [ion binding]; other site
703352005557	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
703352005558	Aspartase; Region: Aspartase; cd01357
703352005559	active sites [active]
703352005560	tetramer interface [polypeptide binding]; other site
703352005561	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
703352005562	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
703352005563	Walker A/P-loop; other site
703352005564	ATP binding site [chemical binding]; other site
703352005565	Q-loop/lid; other site
703352005566	ABC transporter signature motif; other site
703352005567	Walker B; other site
703352005568	D-loop; other site
703352005569	H-loop/switch region; other site
703352005570	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
703352005571	active site
703352005572	homotetramer interface [polypeptide binding]; other site
703352005573	homodimer interface [polypeptide binding]; other site
703352005574	Transcriptional regulators [Transcription]; Region: GntR; COG1802
703352005575	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
703352005576	DNA-binding site [nucleotide binding]; DNA binding site
703352005577	FCD domain; Region: FCD; pfam07729
703352005578	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
703352005579	active site
703352005580	homodimer interface [polypeptide binding]; other site
703352005581	homotetramer interface [polypeptide binding]; other site
703352005582	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
703352005583	D-galactonate transporter; Region: 2A0114; TIGR00893
703352005584	putative substrate translocation pore; other site
703352005585	methionine gamma-lyase; Validated; Region: PRK07049
703352005586	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
703352005587	homodimer interface [polypeptide binding]; other site
703352005588	substrate-cofactor binding pocket; other site
703352005589	pyridoxal 5'-phosphate binding site [chemical binding]; other site
703352005590	catalytic residue [active]
703352005591	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
703352005592	Ligand Binding Site [chemical binding]; other site
703352005593	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
703352005594	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
703352005595	dimer interface [polypeptide binding]; other site
703352005596	pyridoxal 5'-phosphate binding site [chemical binding]; other site
703352005597	catalytic residue [active]
703352005598	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530
703352005599	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
703352005600	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
703352005601	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
703352005602	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
703352005603	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
703352005604	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
703352005605	Ligand binding site [chemical binding]; other site
703352005606	Electron transfer flavoprotein domain; Region: ETF; pfam01012
703352005607	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
703352005608	Ligand Binding Site [chemical binding]; other site
703352005609	6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720
703352005610	active site
703352005611	7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365
703352005612	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
703352005613	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
703352005614	Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588
703352005615	short chain dehydrogenase; Provisional; Region: PRK05993
703352005616	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
703352005617	NADP binding site [chemical binding]; other site
703352005618	active site
703352005619	steroid binding site; other site
703352005620	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
703352005621	hypothetical protein; Validated; Region: PRK00124
703352005622	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
703352005623	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
703352005624	catalytic residues [active]
703352005625	argininosuccinate lyase; Provisional; Region: PRK00855
703352005626	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
703352005627	active sites [active]
703352005628	tetramer interface [polypeptide binding]; other site
703352005629	Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567
703352005630	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
703352005631	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
703352005632	active site
703352005633	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
703352005634	substrate binding site [chemical binding]; other site
703352005635	catalytic residues [active]
703352005636	dimer interface [polypeptide binding]; other site
703352005637	TIGR02302 family protein; Region: aProt_lowcomp
703352005638	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
703352005639	active site
703352005640	Methyltransferase domain; Region: Methyltransf_23; pfam13489
703352005641	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
703352005642	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
703352005643	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
703352005644	pyridoxal 5'-phosphate binding site [chemical binding]; other site
703352005645	homodimer interface [polypeptide binding]; other site
703352005646	catalytic residue [active]
703352005647	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
703352005648	prephenate dehydrogenase; Validated; Region: PRK08507
703352005649	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4093
703352005650	Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898
703352005651	Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703
703352005652	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
703352005653	putative active site pocket [active]
703352005654	dimerization interface [polypeptide binding]; other site
703352005655	putative catalytic residue [active]
703352005656	YGGT family; Region: YGGT; pfam02325
703352005657	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
703352005658	dimer interface [polypeptide binding]; other site
703352005659	substrate binding site [chemical binding]; other site
703352005660	metal binding sites [ion binding]; metal-binding site
703352005661	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
703352005662	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
703352005663	putative acyl-acceptor binding pocket; other site
703352005664	Uncharacterized conserved protein [Function unknown]; Region: COG1434
703352005665	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
703352005666	putative active site [active]
703352005667	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
703352005668	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
703352005669	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
703352005670	Walker A/P-loop; other site
703352005671	ATP binding site [chemical binding]; other site
703352005672	Q-loop/lid; other site
703352005673	ABC transporter signature motif; other site
703352005674	Walker B; other site
703352005675	D-loop; other site
703352005676	H-loop/switch region; other site
703352005677	aquaporin Z; Provisional; Region: PRK05420
703352005678	amphipathic channel; other site
703352005679	Asn-Pro-Ala signature motifs; other site
703352005680	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
703352005681	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
703352005682	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
703352005683	putative catalytic site [active]
703352005684	putative phosphate binding site [ion binding]; other site
703352005685	active site
703352005686	metal binding site A [ion binding]; metal-binding site
703352005687	DNA binding site [nucleotide binding]
703352005688	putative AP binding site [nucleotide binding]; other site
703352005689	putative metal binding site B [ion binding]; other site
703352005690	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
703352005691	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
703352005692	ligand binding site [chemical binding]; other site
703352005693	flexible hinge region; other site
703352005694	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
703352005695	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
703352005696	active site
703352005697	phosphorylation site [posttranslational modification]
703352005698	intermolecular recognition site; other site
703352005699	dimerization interface [polypeptide binding]; other site
703352005700	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
703352005701	DNA binding site [nucleotide binding]
703352005702	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
703352005703	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
703352005704	potential frameshift: common BLAST hit: gi|256370413|ref|YP_003107924.1| outer membrane autotransporter
703352005705	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
703352005706	Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468
703352005707	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
703352005708	Autotransporter beta-domain; Region: Autotransporter; smart00869
703352005709	Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738
703352005710	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
703352005711	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
703352005712	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
703352005713	DNA binding residues [nucleotide binding]
703352005714	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
703352005715	dimer interface [polypeptide binding]; other site
703352005716	putative metal binding site [ion binding]; other site
703352005717	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
703352005718	metal-binding site [ion binding]
703352005719	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
703352005720	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
703352005721	metal-binding site [ion binding]
703352005722	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
703352005723	Soluble P-type ATPase [General function prediction only]; Region: COG4087
703352005724	Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase) [Coenzyme metabolism]; Region: CobT; COG4547
703352005725	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
703352005726	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
703352005727	metal ion-dependent adhesion site (MIDAS); other site
703352005728	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
703352005729	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
703352005730	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
703352005731	DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214
703352005732	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
703352005733	HSP70 interaction site [polypeptide binding]; other site
703352005734	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
703352005735	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
703352005736	Domain of unknown function DUF21; Region: DUF21; pfam01595
703352005737	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
703352005738	Transporter associated domain; Region: CorC_HlyC; smart01091
703352005739	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
703352005740	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
703352005741	active site
703352005742	dimer interface [polypeptide binding]; other site
703352005743	metal binding site [ion binding]; metal-binding site
703352005744	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
703352005745	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
703352005746	ADP binding site [chemical binding]; other site
703352005747	magnesium binding site [ion binding]; other site
703352005748	putative shikimate binding site; other site
703352005749	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
703352005750	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
703352005751	active site
703352005752	DNA binding site [nucleotide binding]
703352005753	Int/Topo IB signature motif; other site
703352005754	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
703352005755	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
703352005756	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
703352005757	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
703352005758	CPxP  motif; other site
703352005759	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
703352005760	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
703352005761	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
703352005762	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
703352005763	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
703352005764	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
703352005765	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
703352005766	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
703352005767	metal binding site [ion binding]; metal-binding site
703352005768	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
703352005769	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
703352005770	NAD(P) binding site [chemical binding]; other site
703352005771	active site
703352005772	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
703352005773	Domain of unknown function (DUF4354); Region: DUF4354; pfam14263
703352005774	potential frameshift: common BLAST hit: gi|340791625|ref|YP_004757090.1| L-sorbose dehydrogenase, FAD dependent
703352005775	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
703352005776	potential frameshift: common BLAST hit: gi|340791625|ref|YP_004757090.1| L-sorbose dehydrogenase, FAD dependent
703352005777	GMC oxidoreductase; Region: GMC_oxred_N; pfam00732
703352005778	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
703352005779	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
703352005780	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745
703352005781	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
703352005782	NAD(P) binding site [chemical binding]; other site
703352005783	active site
703352005784	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
703352005785	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
703352005786	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
703352005787	Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118
703352005788	NAD(P) binding site [chemical binding]; other site
703352005789	catalytic residues [active]
703352005790	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
703352005791	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
703352005792	substrate binding site [chemical binding]; other site
703352005793	oxyanion hole (OAH) forming residues; other site
703352005794	trimer interface [polypeptide binding]; other site
703352005795	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
703352005796	Coenzyme A transferase; Region: CoA_trans; smart00882
703352005797	Coenzyme A transferase; Region: CoA_trans; cl17247
703352005798	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
703352005799	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
703352005800	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
703352005801	Transcriptional regulators [Transcription]; Region: PurR; COG1609
703352005802	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
703352005803	DNA binding site [nucleotide binding]
703352005804	domain linker motif; other site
703352005805	Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289
703352005806	putative dimerization interface [polypeptide binding]; other site
703352005807	putative ligand binding site [chemical binding]; other site
703352005808	Protein of unknown function (DUF993); Region: DUF993; pfam06187
703352005809	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
703352005810	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
703352005811	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
703352005812	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
703352005813	zinc binding site [ion binding]; other site
703352005814	putative ligand binding site [chemical binding]; other site
703352005815	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
703352005816	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
703352005817	TM-ABC transporter signature motif; other site
703352005818	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
703352005819	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
703352005820	Walker A/P-loop; other site
703352005821	ATP binding site [chemical binding]; other site
703352005822	Q-loop/lid; other site
703352005823	ABC transporter signature motif; other site
703352005824	Walker B; other site
703352005825	D-loop; other site
703352005826	H-loop/switch region; other site
703352005827	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585
703352005828	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
703352005829	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
703352005830	ParB-like nuclease domain; Region: ParB; smart00470
703352005831	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
703352005832	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
703352005833	P-loop; other site
703352005834	Magnesium ion binding site [ion binding]; other site
703352005835	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
703352005836	Magnesium ion binding site [ion binding]; other site
703352005837	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
703352005838	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
703352005839	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
703352005840	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
703352005841	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
703352005842	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
703352005843	Predicted GTPase [General function prediction only]; Region: ThdF; COG0486
703352005844	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
703352005845	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
703352005846	trmE is a tRNA modification GTPase; Region: trmE; cd04164
703352005847	G1 box; other site
703352005848	G1 box; other site
703352005849	GTP/Mg2+ binding site [chemical binding]; other site
703352005850	GTP/Mg2+ binding site [chemical binding]; other site
703352005851	Switch I region; other site
703352005852	Switch I region; other site
703352005853	G2 box; other site
703352005854	G2 box; other site
703352005855	Switch II region; other site
703352005856	G3 box; other site
703352005857	G4 box; other site
703352005858	G5 box; other site
703352005859	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
703352005860	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
703352005861	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
703352005862	catalytic residues [active]
703352005863	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
703352005864	transcription termination factor Rho; Provisional; Region: rho; PRK09376
703352005865	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
703352005866	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
703352005867	RNA binding site [nucleotide binding]; other site
703352005868	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
703352005869	multimer interface [polypeptide binding]; other site
703352005870	Walker A motif; other site
703352005871	ATP binding site [chemical binding]; other site
703352005872	Walker B motif; other site
703352005873	Predicted membrane protein [Function unknown]; Region: COG1981
703352005874	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
703352005875	substrate binding site [chemical binding]; other site
703352005876	active site
703352005877	PEP synthetase regulatory protein; Provisional; Region: PRK05339
703352005878	Maf-like protein; Reviewed; Region: PRK00078
703352005879	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
703352005880	active site
703352005881	dimer interface [polypeptide binding]; other site
703352005882	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
703352005883	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
703352005884	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
703352005885	shikimate binding site; other site
703352005886	NAD(P) binding site [chemical binding]; other site
703352005887	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
703352005888	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
703352005889	CoA-binding site [chemical binding]; other site
703352005890	ATP-binding [chemical binding]; other site
703352005891	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
703352005892	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
703352005893	active site
703352005894	catalytic site [active]
703352005895	substrate binding site [chemical binding]; other site
703352005896	preprotein translocase subunit SecB; Validated; Region: PRK05751
703352005897	SecA binding site; other site
703352005898	Preprotein binding site; other site
703352005899	Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030
703352005900	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395
703352005901	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
703352005902	MltA specific insert domain; Region: MltA; pfam03562
703352005903	3D domain; Region: 3D; pfam06725
703352005904	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
703352005905	Smr domain; Region: Smr; pfam01713
703352005906	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
703352005907	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
703352005908	non-specific DNA binding site [nucleotide binding]; other site
703352005909	salt bridge; other site
703352005910	sequence-specific DNA binding site [nucleotide binding]; other site
703352005911	Protein of unknown function (DUF1402); Region: DUF1402; pfam07182
703352005912	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
703352005913	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
703352005914	Walker A motif; other site
703352005915	ATP binding site [chemical binding]; other site
703352005916	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
703352005917	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
703352005918	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
703352005919	active site
703352005920	HslU subunit interaction site [polypeptide binding]; other site
703352005921	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
703352005922	putative active site pocket [active]
703352005923	4-fold oligomerization interface [polypeptide binding]; other site
703352005924	metal binding residues [ion binding]; metal-binding site
703352005925	3-fold/trimer interface [polypeptide binding]; other site
703352005926	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
703352005927	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
703352005928	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
703352005929	putative active site [active]
703352005930	oxyanion strand; other site
703352005931	catalytic triad [active]
703352005932	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
703352005933	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
703352005934	catalytic residues [active]
703352005935	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
703352005936	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
703352005937	substrate binding site [chemical binding]; other site
703352005938	glutamase interaction surface [polypeptide binding]; other site
703352005939	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
703352005940	metal binding site [ion binding]; metal-binding site
703352005941	pantothenate kinase; Provisional; Region: PRK05439
703352005942	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
703352005943	ATP-binding site [chemical binding]; other site
703352005944	CoA-binding site [chemical binding]; other site
703352005945	Mg2+-binding site [ion binding]; other site
703352005946	hypothetical protein; Provisional; Region: PRK09256
703352005947	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
703352005948	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
703352005949	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
703352005950	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
703352005951	active site
703352005952	substrate-binding site [chemical binding]; other site
703352005953	metal-binding site [ion binding]
703352005954	ATP binding site [chemical binding]; other site
703352005955	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
703352005956	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
703352005957	active site
703352005958	phosphorylation site [posttranslational modification]
703352005959	intermolecular recognition site; other site
703352005960	dimerization interface [polypeptide binding]; other site
703352005961	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
703352005962	DNA binding site [nucleotide binding]
703352005963	Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755
703352005964	Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756
703352005965	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
703352005966	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
703352005967	dimerization interface [polypeptide binding]; other site
703352005968	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
703352005969	dimer interface [polypeptide binding]; other site
703352005970	phosphorylation site [posttranslational modification]
703352005971	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
703352005972	ATP binding site [chemical binding]; other site
703352005973	Mg2+ binding site [ion binding]; other site
703352005974	G-X-G motif; other site
703352005975	Serine kinase of the HPr protein, regulates carbohydrate metabolism [Signal transduction mechanisms]; Region: HprK; COG1493
703352005976	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
703352005977	Hpr binding site; other site
703352005978	active site
703352005979	homohexamer subunit interaction site [polypeptide binding]; other site
703352005980	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
703352005981	active pocket/dimerization site; other site
703352005982	active site
703352005983	phosphorylation site [posttranslational modification]
703352005984	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
703352005985	dimerization domain swap beta strand [polypeptide binding]; other site
703352005986	regulatory protein interface [polypeptide binding]; other site
703352005987	active site
703352005988	regulatory phosphorylation site [posttranslational modification]; other site
703352005989	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
703352005990	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
703352005991	homotetramer interface [polypeptide binding]; other site
703352005992	ligand binding site [chemical binding]; other site
703352005993	catalytic site [active]
703352005994	NAD binding site [chemical binding]; other site
703352005995	PAS fold; Region: PAS_7; pfam12860
703352005996	PAS fold; Region: PAS_7; pfam12860
703352005997	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
703352005998	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
703352005999	dimer interface [polypeptide binding]; other site
703352006000	phosphorylation site [posttranslational modification]
703352006001	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
703352006002	ATP binding site [chemical binding]; other site
703352006003	Mg2+ binding site [ion binding]; other site
703352006004	G-X-G motif; other site
703352006005	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
703352006006	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
703352006007	Phosphotransferase enzyme family; Region: APH; pfam01636
703352006008	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
703352006009	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
703352006010	Substrate binding site; other site
703352006011	metal-binding site
703352006012	double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786
703352006013	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
703352006014	double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784
703352006015	Part of AAA domain; Region: AAA_19; pfam13245
703352006016	Family description; Region: UvrD_C_2; pfam13538
703352006017	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
703352006018	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
703352006019	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
703352006020	catalytic residues [active]
703352006021	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
703352006022	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
703352006023	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
703352006024	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
703352006025	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
703352006026	substrate binding site [chemical binding]; other site
703352006027	active site
703352006028	catalytic residues [active]
703352006029	heterodimer interface [polypeptide binding]; other site
703352006030	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
703352006031	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
703352006032	pyridoxal 5'-phosphate binding site [chemical binding]; other site
703352006033	catalytic residue [active]
703352006034	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
703352006035	active site
703352006036	Uncharacterized conserved protein [Function unknown]; Region: COG1434
703352006037	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
703352006038	putative active site [active]
703352006039	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
703352006040	Protein of unknown function (DUF2852); Region: DUF2852; pfam11014
703352006041	Protein of unknown function (DUF2852); Region: DUF2852; pfam11014
703352006042	Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135
703352006043	benzoate transporter; Region: benE; TIGR00843
703352006044	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
703352006045	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
703352006046	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
703352006047	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
703352006048	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
703352006049	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
703352006050	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
703352006051	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
703352006052	23S rRNA binding site [nucleotide binding]; other site
703352006053	L21 binding site [polypeptide binding]; other site
703352006054	L13 binding site [polypeptide binding]; other site
703352006055	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
703352006056	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
703352006057	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
703352006058	dimer interface [polypeptide binding]; other site
703352006059	motif 1; other site
703352006060	active site
703352006061	motif 2; other site
703352006062	motif 3; other site
703352006063	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
703352006064	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
703352006065	putative tRNA-binding site [nucleotide binding]; other site
703352006066	B3/4 domain; Region: B3_4; pfam03483
703352006067	tRNA synthetase B5 domain; Region: B5; smart00874
703352006068	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
703352006069	dimer interface [polypeptide binding]; other site
703352006070	motif 1; other site
703352006071	motif 3; other site
703352006072	motif 2; other site
703352006073	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
703352006074	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
703352006075	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
703352006076	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
703352006077	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
703352006078	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
703352006079	nucleotide binding site [chemical binding]; other site
703352006080	NEF interaction site [polypeptide binding]; other site
703352006081	SBD interface [polypeptide binding]; other site
703352006082	chaperone protein DnaJ; Provisional; Region: PRK10767
703352006083	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
703352006084	HSP70 interaction site [polypeptide binding]; other site
703352006085	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
703352006086	substrate binding site [polypeptide binding]; other site
703352006087	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
703352006088	Zn binding sites [ion binding]; other site
703352006089	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
703352006090	dimer interface [polypeptide binding]; other site
703352006091	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
703352006092	S-adenosylmethionine binding site [chemical binding]; other site
703352006093	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
703352006094	active site
703352006095	dimer interface [polypeptide binding]; other site
703352006096	Uncharacterized conserved protein [Function unknown]; Region: COG5470
703352006097	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
703352006098	glutathione synthetase; Provisional; Region: PRK05246
703352006099	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
703352006100	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
703352006101	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
703352006102	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
703352006103	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
703352006104	Walker A motif; other site
703352006105	ATP binding site [chemical binding]; other site
703352006106	Walker B motif; other site
703352006107	arginine finger; other site
703352006108	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
703352006109	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035
703352006110	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
703352006111	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
703352006112	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
703352006113	PBP superfamily domain; Region: PBP_like_2; pfam12849
703352006114	Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501
703352006115	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
703352006116	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352006117	dimer interface [polypeptide binding]; other site
703352006118	conserved gate region; other site
703352006119	putative PBP binding loops; other site
703352006120	ABC-ATPase subunit interface; other site
703352006121	Domain of unknown function (DUF3333); Region: DUF3333; pfam11812
703352006122	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
703352006123	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352006124	dimer interface [polypeptide binding]; other site
703352006125	conserved gate region; other site
703352006126	putative PBP binding loops; other site
703352006127	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
703352006128	ABC-ATPase subunit interface; other site
703352006129	phosphate transporter ATP-binding protein; Provisional; Region: PRK14235
703352006130	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
703352006131	Walker A/P-loop; other site
703352006132	ATP binding site [chemical binding]; other site
703352006133	Q-loop/lid; other site
703352006134	ABC transporter signature motif; other site
703352006135	Walker B; other site
703352006136	D-loop; other site
703352006137	H-loop/switch region; other site
703352006138	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
703352006139	PhoU domain; Region: PhoU; pfam01895
703352006140	PhoU domain; Region: PhoU; pfam01895
703352006141	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
703352006142	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
703352006143	active site
703352006144	phosphorylation site [posttranslational modification]
703352006145	intermolecular recognition site; other site
703352006146	dimerization interface [polypeptide binding]; other site
703352006147	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
703352006148	DNA binding site [nucleotide binding]
703352006149	Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773
703352006150	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
703352006151	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
703352006152	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
703352006153	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
703352006154	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
703352006155	dimerization interface [polypeptide binding]; other site
703352006156	DPS ferroxidase diiron center [ion binding]; other site
703352006157	ion pore; other site
703352006158	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
703352006159	Glycoprotease family; Region: Peptidase_M22; pfam00814
703352006160	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
703352006161	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
703352006162	Coenzyme A binding pocket [chemical binding]; other site
703352006163	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
703352006164	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
703352006165	putative acyl-acceptor binding pocket; other site
703352006166	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
703352006167	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
703352006168	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
703352006169	FeS/SAM binding site; other site
703352006170	TRAM domain; Region: TRAM; cl01282
703352006171	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
703352006172	PhoH-like protein; Region: PhoH; pfam02562
703352006173	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319
703352006174	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
703352006175	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
703352006176	Transporter associated domain; Region: CorC_HlyC; smart01091
703352006177	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
703352006178	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
703352006179	putative active site [active]
703352006180	catalytic triad [active]
703352006181	putative dimer interface [polypeptide binding]; other site
703352006182	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
703352006183	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
703352006184	non-specific DNA binding site [nucleotide binding]; other site
703352006185	salt bridge; other site
703352006186	sequence-specific DNA binding site [nucleotide binding]; other site
703352006187	S-adenosylmethionine synthetase; Validated; Region: PRK05250
703352006188	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
703352006189	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
703352006190	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
703352006191	Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only]; Region: COG0220
703352006192	ribosome maturation protein RimP; Reviewed; Region: PRK00092
703352006193	Sm and related proteins; Region: Sm_like; cl00259
703352006194	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
703352006195	putative oligomer interface [polypeptide binding]; other site
703352006196	putative RNA binding site [nucleotide binding]; other site
703352006197	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
703352006198	NusA N-terminal domain; Region: NusA_N; pfam08529
703352006199	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
703352006200	RNA binding site [nucleotide binding]; other site
703352006201	homodimer interface [polypeptide binding]; other site
703352006202	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
703352006203	G-X-X-G motif; other site
703352006204	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
703352006205	G-X-X-G motif; other site
703352006206	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
703352006207	hypothetical protein; Provisional; Region: PRK09190
703352006208	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
703352006209	putative RNA binding cleft [nucleotide binding]; other site
703352006210	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
703352006211	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
703352006212	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
703352006213	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
703352006214	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
703352006215	G1 box; other site
703352006216	putative GEF interaction site [polypeptide binding]; other site
703352006217	GTP/Mg2+ binding site [chemical binding]; other site
703352006218	Switch I region; other site
703352006219	G2 box; other site
703352006220	G3 box; other site
703352006221	Switch II region; other site
703352006222	G4 box; other site
703352006223	G5 box; other site
703352006224	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
703352006225	Translation-initiation factor 2; Region: IF-2; pfam11987
703352006226	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
703352006227	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
703352006228	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389
703352006229	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
703352006230	RNA binding site [nucleotide binding]; other site
703352006231	active site
703352006232	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
703352006233	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
703352006234	16S/18S rRNA binding site [nucleotide binding]; other site
703352006235	S13e-L30e interaction site [polypeptide binding]; other site
703352006236	25S rRNA binding site [nucleotide binding]; other site
703352006237	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
703352006238	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
703352006239	RNase E interface [polypeptide binding]; other site
703352006240	trimer interface [polypeptide binding]; other site
703352006241	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
703352006242	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
703352006243	RNase E interface [polypeptide binding]; other site
703352006244	trimer interface [polypeptide binding]; other site
703352006245	active site
703352006246	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
703352006247	putative nucleic acid binding region [nucleotide binding]; other site
703352006248	G-X-X-G motif; other site
703352006249	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
703352006250	RNA binding site [nucleotide binding]; other site
703352006251	domain interface; other site
703352006252	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
703352006253	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
703352006254	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
703352006255	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505
703352006256	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
703352006257	NAD binding site [chemical binding]; other site
703352006258	homotetramer interface [polypeptide binding]; other site
703352006259	homodimer interface [polypeptide binding]; other site
703352006260	substrate binding site [chemical binding]; other site
703352006261	active site
703352006262	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
703352006263	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
703352006264	dimer interface [polypeptide binding]; other site
703352006265	active site
703352006266	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
703352006267	active site 1 [active]
703352006268	dimer interface [polypeptide binding]; other site
703352006269	active site 2 [active]
703352006270	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
703352006271	metal binding site 2 [ion binding]; metal-binding site
703352006272	putative DNA binding helix; other site
703352006273	metal binding site 1 [ion binding]; metal-binding site
703352006274	dimer interface [polypeptide binding]; other site
703352006275	structural Zn2+ binding site [ion binding]; other site
703352006276	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
703352006277	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
703352006278	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807
703352006279	Bacterial SH3 domain; Region: SH3_4; pfam06347
703352006280	Bacterial SH3 domain; Region: SH3_4; pfam06347
703352006281	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
703352006282	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
703352006283	dimerization interface [polypeptide binding]; other site
703352006284	ligand binding site [chemical binding]; other site
703352006285	NADP binding site [chemical binding]; other site
703352006286	catalytic site [active]
703352006287	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
703352006288	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
703352006289	NlpC/P60 family; Region: NLPC_P60; cl17555
703352006290	Transcriptional regulators [Transcription]; Region: MarR; COG1846
703352006291	MarR family; Region: MarR; pfam01047
703352006292	multifunctional aminopeptidase A; Provisional; Region: PRK00913
703352006293	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
703352006294	interface (dimer of trimers) [polypeptide binding]; other site
703352006295	Substrate-binding/catalytic site; other site
703352006296	Zn-binding sites [ion binding]; other site
703352006297	Flp/Fap pilin component; Region: Flp_Fap; cl01585
703352006298	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
703352006299	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
703352006300	DNA binding site [nucleotide binding]
703352006301	catalytic residue [active]
703352006302	H2TH interface [polypeptide binding]; other site
703352006303	putative catalytic residues [active]
703352006304	turnover-facilitating residue; other site
703352006305	intercalation triad [nucleotide binding]; other site
703352006306	8OG recognition residue [nucleotide binding]; other site
703352006307	putative reading head residues; other site
703352006308	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
703352006309	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
703352006310	enoyl-CoA hydratase; Provisional; Region: PRK05862
703352006311	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
703352006312	substrate binding site [chemical binding]; other site
703352006313	oxyanion hole (OAH) forming residues; other site
703352006314	trimer interface [polypeptide binding]; other site
703352006315	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
703352006316	replication initiation protein RepC; Provisional; Region: PRK13824
703352006317	Replication protein C N-terminal domain; Region: RP-C; pfam03428
703352006318	Replication protein C C-terminal region; Region: RP-C_C; pfam11800
703352006319	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
703352006320	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
703352006321	substrate binding site [chemical binding]; other site
703352006322	dimer interface [polypeptide binding]; other site
703352006323	ATP binding site [chemical binding]; other site
703352006324	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
703352006325	active site
703352006326	tetramer interface [polypeptide binding]; other site
703352006327	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
703352006328	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
703352006329	TM-ABC transporter signature motif; other site
703352006330	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
703352006331	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
703352006332	TM-ABC transporter signature motif; other site
703352006333	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
703352006334	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
703352006335	Walker A/P-loop; other site
703352006336	ATP binding site [chemical binding]; other site
703352006337	Q-loop/lid; other site
703352006338	ABC transporter signature motif; other site
703352006339	Walker B; other site
703352006340	D-loop; other site
703352006341	H-loop/switch region; other site
703352006342	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
703352006343	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
703352006344	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
703352006345	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
703352006346	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
703352006347	Predicted secreted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5664
703352006348	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
703352006349	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
703352006350	2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220
703352006351	2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331
703352006352	putative NAD(P) binding site [chemical binding]; other site
703352006353	active site
703352006354	Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013
703352006355	hydrophobic substrate binding pocket; other site
703352006356	Isochorismatase family; Region: Isochorismatase; pfam00857
703352006357	active site
703352006358	conserved cis-peptide bond; other site
703352006359	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
703352006360	enterobactin synthase subunit E; Provisional; Region: entE; PRK10946
703352006361	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
703352006362	acyl-activating enzyme (AAE) consensus motif; other site
703352006363	active site
703352006364	AMP binding site [chemical binding]; other site
703352006365	substrate binding site [chemical binding]; other site
703352006366	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
703352006367	isochorismate synthases; Region: isochor_syn; TIGR00543
703352006368	Condensation domain; Region: Condensation; pfam00668
703352006369	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
703352006370	bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108
703352006371	Moco binding site; other site
703352006372	metal coordination site [ion binding]; other site
703352006373	Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117
703352006374	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
703352006375	pentapeptide MXKDX repeat protein; Region: penta_MxKDx; TIGR02953
703352006376	RNA polymerase sigma factor; Provisional; Region: PRK12539
703352006377	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
703352006378	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
703352006379	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4944
703352006380	Transcriptional regulators [Transcription]; Region: FadR; COG2186
703352006381	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
703352006382	DNA-binding site [nucleotide binding]; DNA binding site
703352006383	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
703352006384	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
703352006385	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329
703352006386	putative ligand binding site [chemical binding]; other site
703352006387	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
703352006388	TM-ABC transporter signature motif; other site
703352006389	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
703352006390	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
703352006391	TM-ABC transporter signature motif; other site
703352006392	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
703352006393	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
703352006394	Walker A/P-loop; other site
703352006395	ATP binding site [chemical binding]; other site
703352006396	Q-loop/lid; other site
703352006397	ABC transporter signature motif; other site
703352006398	Walker B; other site
703352006399	D-loop; other site
703352006400	H-loop/switch region; other site
703352006401	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
703352006402	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
703352006403	Walker A/P-loop; other site
703352006404	ATP binding site [chemical binding]; other site
703352006405	Q-loop/lid; other site
703352006406	ABC transporter signature motif; other site
703352006407	Walker B; other site
703352006408	D-loop; other site
703352006409	H-loop/switch region; other site
703352006410	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
703352006411	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
703352006412	active site
703352006413	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
703352006414	classical (c) SDRs; Region: SDR_c; cd05233
703352006415	NAD(P) binding site [chemical binding]; other site
703352006416	active site
703352006417	classical (c) SDRs; Region: SDR_c; cd05233
703352006418	NAD(P) binding site [chemical binding]; other site
703352006419	active site
703352006420	potential frameshift: common BLAST hit: gi|376270582|ref|YP_005113627.1| dehydrogenase E1 component
703352006421	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
703352006422	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
703352006423	tetramer interface [polypeptide binding]; other site
703352006424	TPP-binding site [chemical binding]; other site
703352006425	heterodimer interface [polypeptide binding]; other site
703352006426	phosphorylation loop region [posttranslational modification]
703352006427	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
703352006428	PYR/PP interface [polypeptide binding]; other site
703352006429	TPP binding site [chemical binding]; other site
703352006430	dimer interface [polypeptide binding]; other site
703352006431	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
703352006432	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
703352006433	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
703352006434	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
703352006435	E3 interaction surface; other site
703352006436	lipoyl attachment site [posttranslational modification]; other site
703352006437	e3 binding domain; Region: E3_binding; pfam02817
703352006438	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
703352006439	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
703352006440	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
703352006441	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
703352006442	shikimate binding site; other site
703352006443	NAD(P) binding site [chemical binding]; other site
703352006444	magnesium-transporting ATPase; Provisional; Region: PRK15122
703352006445	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
703352006446	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
703352006447	Soluble P-type ATPase [General function prediction only]; Region: COG4087
703352006448	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
703352006449	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
703352006450	MgtC family; Region: MgtC; pfam02308
703352006451	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
703352006452	ATP binding site [chemical binding]; other site
703352006453	Mg2+ binding site [ion binding]; other site
703352006454	G-X-G motif; other site
703352006455	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
703352006456	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
703352006457	active site
703352006458	phosphorylation site [posttranslational modification]
703352006459	intermolecular recognition site; other site
703352006460	dimerization interface [polypeptide binding]; other site
703352006461	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
703352006462	dimerization interface [polypeptide binding]; other site
703352006463	DNA binding residues [nucleotide binding]
703352006464	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
703352006465	Response regulator receiver domain; Region: Response_reg; pfam00072
703352006466	active site
703352006467	phosphorylation site [posttranslational modification]
703352006468	intermolecular recognition site; other site
703352006469	dimerization interface [polypeptide binding]; other site
703352006470	N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: HutG; COG3741
703352006471	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
703352006472	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
703352006473	active site
703352006474	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
703352006475	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
703352006476	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
703352006477	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
703352006478	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
703352006479	putative dimer interface [polypeptide binding]; other site
703352006480	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
703352006481	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
703352006482	tetramer interface [polypeptide binding]; other site
703352006483	pyridoxal 5'-phosphate binding site [chemical binding]; other site
703352006484	catalytic residue [active]
703352006485	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
703352006486	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
703352006487	active site
703352006488	dimer interface [polypeptide binding]; other site
703352006489	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
703352006490	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
703352006491	active site
703352006492	FMN binding site [chemical binding]; other site
703352006493	substrate binding site [chemical binding]; other site
703352006494	3Fe-4S cluster binding site [ion binding]; other site
703352006495	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
703352006496	domain interface; other site
703352006497	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
703352006498	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
703352006499	SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829
703352006500	active site
703352006501	catalytic triad [active]
703352006502	oxyanion hole [active]
703352006503	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
703352006504	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
703352006505	ligand binding site [chemical binding]; other site
703352006506	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
703352006507	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
703352006508	ATP binding site [chemical binding]; other site
703352006509	Walker A motif; other site
703352006510	hexamer interface [polypeptide binding]; other site
703352006511	Walker B motif; other site
703352006512	Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948
703352006513	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423
703352006514	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
703352006515	VirB7 interaction site; other site
703352006516	Type IV secretory pathway, component VirB8 [Intracellular trafficking and secretion]; Region: VirB8; COG3736
703352006517	Type IV secretory pathway, VirB6 components [Intracellular trafficking and secretion]; Region: VirB6; COG3704
703352006518	P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791
703352006519	Type IV secretion system proteins; Region: T4SS; pfam07996
703352006520	Type IV secretory pathway, VirB4 components [Intracellular trafficking and secretion]; Region: VirB4; COG3451
703352006521	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
703352006522	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
703352006523	TrbC/VIRB2 family; Region: TrbC; cl01583
703352006524	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
703352006525	N-acetyl-D-glucosamine binding site [chemical binding]; other site
703352006526	catalytic residue [active]
703352006527	lytic murein transglycosylase; Region: MltB_2; TIGR02283
703352006528	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
703352006529	N-acetyl-D-glucosamine binding site [chemical binding]; other site
703352006530	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
703352006531	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
703352006532	active site
703352006533	tetramer interface; other site
703352006534	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5338
703352006535	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082
703352006536	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
703352006537	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
703352006538	putative active site [active]
703352006539	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
703352006540	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
703352006541	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
703352006542	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
703352006543	ferrochelatase; Reviewed; Region: hemH; PRK00035
703352006544	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
703352006545	C-terminal domain interface [polypeptide binding]; other site
703352006546	active site
703352006547	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
703352006548	active site
703352006549	N-terminal domain interface [polypeptide binding]; other site
703352006550	Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310
703352006551	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
703352006552	Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310
703352006553	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
703352006554	hypothetical protein; Provisional; Region: PRK07546
703352006555	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
703352006556	substrate-cofactor binding pocket; other site
703352006557	pyridoxal 5'-phosphate binding site [chemical binding]; other site
703352006558	homodimer interface [polypeptide binding]; other site
703352006559	catalytic residue [active]
703352006560	aminodeoxychorismate synthase; Provisional; Region: PRK07508
703352006561	chorismate binding enzyme; Region: Chorismate_bind; cl10555
703352006562	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
703352006563	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610
703352006564	active site
703352006565	Zn binding site [ion binding]; other site
703352006566	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
703352006567	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
703352006568	active site
703352006569	phosphorylation site [posttranslational modification]
703352006570	intermolecular recognition site; other site
703352006571	dimerization interface [polypeptide binding]; other site
703352006572	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
703352006573	Walker A motif; other site
703352006574	ATP binding site [chemical binding]; other site
703352006575	Walker B motif; other site
703352006576	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
703352006577	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
703352006578	Bacterial protein of unknown function (DUF882); Region: Peptidase_M15_2; pfam05951
703352006579	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
703352006580	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
703352006581	active site
703352006582	intersubunit interface [polypeptide binding]; other site
703352006583	catalytic residue [active]
703352006584	Protein of unknown function (DUF3380); Region: DUF3380; pfam11860
703352006585	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
703352006586	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
703352006587	active site residue [active]
703352006588	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
703352006589	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
703352006590	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352006591	dimer interface [polypeptide binding]; other site
703352006592	conserved gate region; other site
703352006593	putative PBP binding loops; other site
703352006594	ABC-ATPase subunit interface; other site
703352006595	ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148
703352006596	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
703352006597	Walker A/P-loop; other site
703352006598	ATP binding site [chemical binding]; other site
703352006599	Q-loop/lid; other site
703352006600	ABC transporter signature motif; other site
703352006601	Walker B; other site
703352006602	D-loop; other site
703352006603	H-loop/switch region; other site
703352006604	TOBE domain; Region: TOBE; cl01440
703352006605	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
703352006606	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215
703352006607	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683
703352006608	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
703352006609	LysR family transcriptional regulator; Provisional; Region: PRK14997
703352006610	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
703352006611	putative effector binding pocket; other site
703352006612	dimerization interface [polypeptide binding]; other site
703352006613	amidase; Provisional; Region: PRK08310
703352006614	indole-3-acetamide amidohydrolase; Region: PLN02722
703352006615	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
703352006616	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
703352006617	dimer interface [polypeptide binding]; other site
703352006618	active site
703352006619	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
703352006620	catalytic residues [active]
703352006621	substrate binding site [chemical binding]; other site
703352006622	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
703352006623	Chain length determinant protein; Region: Wzz; pfam02706
703352006624	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
703352006625	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
703352006626	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
703352006627	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
703352006628	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
703352006629	active site
703352006630	potential frameshift: common BLAST hit: gi|376278096|ref|YP_005108129.1| exopolysaccharide production protein, putative
703352006631	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
703352006632	O-Antigen ligase; Region: Wzy_C; pfam04932
703352006633	potential frameshift: common BLAST hit: gi|376278097|ref|YP_005108130.1| Gfo/Idh/MocA family oxidoreductase
703352006634	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
703352006635	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
703352006636	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
703352006637	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
703352006638	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
703352006639	6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG0362
703352006640	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
703352006641	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
703352006642	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
703352006643	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
703352006644	Walker A/P-loop; other site
703352006645	ATP binding site [chemical binding]; other site
703352006646	Q-loop/lid; other site
703352006647	ABC transporter signature motif; other site
703352006648	Walker B; other site
703352006649	D-loop; other site
703352006650	H-loop/switch region; other site
703352006651	TOBE domain; Region: TOBE_2; pfam08402
703352006652	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
703352006653	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352006654	dimer interface [polypeptide binding]; other site
703352006655	conserved gate region; other site
703352006656	putative PBP binding loops; other site
703352006657	ABC-ATPase subunit interface; other site
703352006658	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352006659	dimer interface [polypeptide binding]; other site
703352006660	conserved gate region; other site
703352006661	putative PBP binding loops; other site
703352006662	ABC-ATPase subunit interface; other site
703352006663	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
703352006664	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
703352006665	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
703352006666	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
703352006667	putative substrate translocation pore; other site
703352006668	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
703352006669	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
703352006670	HlyD family secretion protein; Region: HlyD_3; pfam13437
703352006671	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
703352006672	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
703352006673	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
703352006674	Autoinducer binding domain; Region: Autoind_bind; pfam03472
703352006675	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
703352006676	DNA binding residues [nucleotide binding]
703352006677	dimerization interface [polypeptide binding]; other site
703352006678	Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377
703352006679	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
703352006680	FliG C-terminal domain; Region: FliG_C; pfam01706
703352006681	Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536
703352006682	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
703352006683	Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868
703352006684	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
703352006685	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
703352006686	flagellar motor protein MotA; Validated; Region: PRK09110
703352006687	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
703352006688	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
703352006689	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642
703352006690	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
703352006691	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
703352006692	flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002
703352006693	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
703352006694	Walker A motif; other site
703352006695	ATP binding site [chemical binding]; other site
703352006696	Walker B motif; other site
703352006697	PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389
703352006698	active site
703352006699	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
703352006700	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
703352006701	Ligand binding site; other site
703352006702	Putative Catalytic site; other site
703352006703	DXD motif; other site
703352006704	Peptidase family M48; Region: Peptidase_M48; cl12018
703352006705	uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807
703352006706	putative active site [active]
703352006707	YdjC motif; other site
703352006708	Mg binding site [ion binding]; other site
703352006709	putative homodimer interface [polypeptide binding]; other site
703352006710	potential frameshift: common BLAST hit: gi|376278123|ref|YP_005108156.1| dolichyl-phosphate-mannose-protein mannosyltransferase family
703352006711	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
703352006712	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
703352006713	Helix-turn-helix domain; Region: HTH_18; pfam12833
703352006714	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
703352006715	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
703352006716	D-galactonate transporter; Region: 2A0114; TIGR00893
703352006717	putative substrate translocation pore; other site
703352006718	putative aldolase; Validated; Region: PRK08130
703352006719	intersubunit interface [polypeptide binding]; other site
703352006720	active site
703352006721	Zn2+ binding site [ion binding]; other site
703352006722	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
703352006723	Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238
703352006724	putative NAD(P) binding site [chemical binding]; other site
703352006725	active site
703352006726	putative substrate binding site [chemical binding]; other site
703352006727	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
703352006728	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
703352006729	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
703352006730	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
703352006731	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
703352006732	Metal-binding active site; metal-binding site
703352006733	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
703352006734	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
703352006735	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003
703352006736	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782
703352006737	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
703352006738	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
703352006739	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790
703352006740	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691
703352006741	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
703352006742	flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK06005
703352006743	Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261
703352006744	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
703352006745	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
703352006746	Uncharacterized conserved protein [Function unknown]; Region: COG3334
703352006747	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
703352006748	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
703352006749	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
703352006750	FliP family; Region: FliP; cl00593
703352006751	Uncharacterized protein conserved in bacteria (DUF2195); Region: DUF2195; cl02042
703352006752	Transcriptional regulator [Transcription]; Region: LysR; COG0583
703352006753	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
703352006754	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
703352006755	putative dimerization interface [polypeptide binding]; other site
703352006756	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
703352006757	CoA-transferase family III; Region: CoA_transf_3; pfam02515
703352006758	Uncharacterized conserved protein [Function unknown]; Region: COG3777
703352006759	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
703352006760	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
703352006761	active site 2 [active]
703352006762	active site 1 [active]
703352006763	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
703352006764	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
703352006765	potential frameshift: common BLAST hit: gi|189022382|ref|YP_001932123.1| outermembrane transporter
703352006766	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
703352006767	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
703352006768	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
703352006769	Autotransporter beta-domain; Region: Autotransporter; pfam03797
703352006770	Cytochrome c2 [Energy production and conversion]; Region: COG3474
703352006771	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841
703352006772	transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464
703352006773	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
703352006774	DNA-binding site [nucleotide binding]; DNA binding site
703352006775	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
703352006776	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
703352006777	transcriptional activator TtdR; Provisional; Region: PRK09801
703352006778	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
703352006779	putative effector binding pocket; other site
703352006780	dimerization interface [polypeptide binding]; other site
703352006781	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
703352006782	FAD binding domain; Region: FAD_binding_4; pfam01565
703352006783	FAD binding domain; Region: FAD_binding_4; pfam01565
703352006784	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
703352006785	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
703352006786	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
703352006787	Cysteine-rich domain; Region: CCG; pfam02754
703352006788	Cysteine-rich domain; Region: CCG; pfam02754
703352006789	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
703352006790	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
703352006791	active site
703352006792	catalytic tetrad [active]
703352006793	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
703352006794	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
703352006795	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
703352006796	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
703352006797	Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124
703352006798	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
703352006799	dimer interface [polypeptide binding]; other site
703352006800	motif 1; other site
703352006801	motif 2; other site
703352006802	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
703352006803	active site
703352006804	motif 3; other site
703352006805	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
703352006806	anticodon binding site; other site
703352006807	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295
703352006808	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
703352006809	motif 1; other site
703352006810	dimer interface [polypeptide binding]; other site
703352006811	active site
703352006812	motif 2; other site
703352006813	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
703352006814	active site
703352006815	motif 3; other site
703352006816	ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583
703352006817	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
703352006818	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
703352006819	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
703352006820	putative substrate translocation pore; other site
703352006821	Predicted membrane protein [Function unknown]; Region: COG2259
703352006822	fumarate hydratase; Reviewed; Region: fumC; PRK00485
703352006823	Class II fumarases; Region: Fumarase_classII; cd01362
703352006824	active site
703352006825	tetramer interface [polypeptide binding]; other site
703352006826	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
703352006827	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
703352006828	ring oligomerisation interface [polypeptide binding]; other site
703352006829	ATP/Mg binding site [chemical binding]; other site
703352006830	stacking interactions; other site
703352006831	hinge regions; other site
703352006832	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
703352006833	oligomerisation interface [polypeptide binding]; other site
703352006834	mobile loop; other site
703352006835	roof hairpin; other site
703352006836	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
703352006837	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
703352006838	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
703352006839	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
703352006840	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
703352006841	active site
703352006842	Riboflavin kinase; Region: Flavokinase; smart00904
703352006843	isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804
703352006844	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
703352006845	active site
703352006846	HIGH motif; other site
703352006847	nucleotide binding site [chemical binding]; other site
703352006848	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
703352006849	active site
703352006850	KMSKS motif; other site
703352006851	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
703352006852	tRNA binding surface [nucleotide binding]; other site
703352006853	anticodon binding site; other site
703352006854	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
703352006855	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
703352006856	nucleoside/Zn binding site; other site
703352006857	dimer interface [polypeptide binding]; other site
703352006858	catalytic motif [active]
703352006859	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
703352006860	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
703352006861	RNA binding surface [nucleotide binding]; other site
703352006862	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
703352006863	active site
703352006864	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
703352006865	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
703352006866	S-adenosylmethionine binding site [chemical binding]; other site
703352006867	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
703352006868	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
703352006869	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
703352006870	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
703352006871	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
703352006872	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
703352006873	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
703352006874	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
703352006875	glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659
703352006876	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
703352006877	TrkA-N domain; Region: TrkA_N; pfam02254
703352006878	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
703352006879	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
703352006880	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
703352006881	active site
703352006882	Domain of unknown function (DUF4170); Region: DUF4170; pfam13773
703352006883	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
703352006884	putative acyl-acceptor binding pocket; other site
703352006885	3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519
703352006886	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
703352006887	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
703352006888	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
703352006889	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
703352006890	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3908
703352006891	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
703352006892	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
703352006893	ATP binding site [chemical binding]; other site
703352006894	Mg2+ binding site [ion binding]; other site
703352006895	G-X-G motif; other site
703352006896	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
703352006897	ATP binding site [chemical binding]; other site
703352006898	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
703352006899	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
703352006900	putative substrate translocation pore; other site
703352006901	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
703352006902	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
703352006903	active site
703352006904	Transcriptional regulator [Transcription]; Region: IclR; COG1414
703352006905	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
703352006906	Bacterial transcriptional regulator; Region: IclR; pfam01614
703352006907	enoyl-CoA hydratase; Provisional; Region: PRK08138
703352006908	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
703352006909	substrate binding site [chemical binding]; other site
703352006910	oxyanion hole (OAH) forming residues; other site
703352006911	trimer interface [polypeptide binding]; other site
703352006912	3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268
703352006913	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
703352006914	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
703352006915	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
703352006916	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
703352006917	CoA-transferase family III; Region: CoA_transf_3; pfam02515
703352006918	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
703352006919	Old yellow enzyme (OYE)-related FMN binding domain, group 2.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733
703352006920	putative active site [active]
703352006921	putative FMN binding site [chemical binding]; other site
703352006922	putative substrate binding site [chemical binding]; other site
703352006923	putative catalytic residue [active]
703352006924	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg7; cd04786
703352006925	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
703352006926	DNA binding residues [nucleotide binding]
703352006927	putative dimer interface [polypeptide binding]; other site
703352006928	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
703352006929	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
703352006930	potential catalytic triad [active]
703352006931	conserved cys residue [active]
703352006932	sensor protein QseC; Provisional; Region: PRK10337
703352006933	HAMP domain; Region: HAMP; pfam00672
703352006934	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
703352006935	dimer interface [polypeptide binding]; other site
703352006936	phosphorylation site [posttranslational modification]
703352006937	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
703352006938	Mg2+ binding site [ion binding]; other site
703352006939	G-X-G motif; other site
703352006940	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
703352006941	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
703352006942	active site
703352006943	phosphorylation site [posttranslational modification]
703352006944	intermolecular recognition site; other site
703352006945	dimerization interface [polypeptide binding]; other site
703352006946	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
703352006947	DNA binding site [nucleotide binding]
703352006948	Uncharacterized conserved protein [Function unknown]; Region: COG5591
703352006949	Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029
703352006950	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
703352006951	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
703352006952	Flavodoxin; Region: Flavodoxin_1; pfam00258
703352006953	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide.  Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like2; cd06201
703352006954	FAD binding pocket [chemical binding]; other site
703352006955	FAD binding motif [chemical binding]; other site
703352006956	catalytic residues [active]
703352006957	NAD binding pocket [chemical binding]; other site
703352006958	phosphate binding motif [ion binding]; other site
703352006959	beta-alpha-beta structure motif; other site
703352006960	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
703352006961	ApbE family; Region: ApbE; pfam02424
703352006962	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
703352006963	GAF domain; Region: GAF; pfam01590
703352006964	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
703352006965	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
703352006966	metal binding site [ion binding]; metal-binding site
703352006967	active site
703352006968	I-site; other site
703352006969	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
703352006970	EamA-like transporter family; Region: EamA; pfam00892
703352006971	EamA-like transporter family; Region: EamA; cl17759
703352006972	Transcriptional regulators [Transcription]; Region: GntR; COG1802
703352006973	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
703352006974	DNA-binding site [nucleotide binding]; DNA binding site
703352006975	FCD domain; Region: FCD; pfam07729
703352006976	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
703352006977	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
703352006978	inhibitor site; inhibition site
703352006979	active site
703352006980	dimer interface [polypeptide binding]; other site
703352006981	catalytic residue [active]
703352006982	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
703352006983	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
703352006984	Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440
703352006985	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
703352006986	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
703352006987	Cytochrome c; Region: Cytochrom_C; pfam00034
703352006988	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
703352006989	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
703352006990	Binuclear center (active site) [active]
703352006991	K-pathway; other site
703352006992	Putative proton exit pathway; other site
703352006993	MoxR-like ATPases [General function prediction only]; Region: COG0714
703352006994	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
703352006995	Walker A motif; other site
703352006996	ATP binding site [chemical binding]; other site
703352006997	Walker B motif; other site
703352006998	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
703352006999	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
703352007000	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
703352007001	metal ion-dependent adhesion site (MIDAS); other site
703352007002	Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719
703352007003	Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006
703352007004	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
703352007005	CPxP  motif; other site
703352007006	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
703352007007	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
703352007008	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
703352007009	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
703352007010	nucleophilic elbow; other site
703352007011	catalytic triad; other site
703352007012	nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376
703352007013	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
703352007014	Multicopper oxidase; Region: Cu-oxidase; pfam00394
703352007015	Uncharacterized conserved protein [Function unknown]; Region: COG1262
703352007016	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
703352007017	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
703352007018	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
703352007019	ligand binding site [chemical binding]; other site
703352007020	flexible hinge region; other site
703352007021	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
703352007022	putative switch regulator; other site
703352007023	non-specific DNA interactions [nucleotide binding]; other site
703352007024	DNA binding site [nucleotide binding]
703352007025	sequence specific DNA binding site [nucleotide binding]; other site
703352007026	putative cAMP binding site [chemical binding]; other site
703352007027	Transcriptional regulators [Transcription]; Region: PurR; COG1609
703352007028	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
703352007029	DNA binding site [nucleotide binding]
703352007030	domain linker motif; other site
703352007031	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
703352007032	dimerization interface [polypeptide binding]; other site
703352007033	ligand binding site [chemical binding]; other site
703352007034	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
703352007035	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
703352007036	putative ligand binding site [chemical binding]; other site
703352007037	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
703352007038	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
703352007039	Walker A/P-loop; other site
703352007040	ATP binding site [chemical binding]; other site
703352007041	Q-loop/lid; other site
703352007042	ABC transporter signature motif; other site
703352007043	Walker B; other site
703352007044	D-loop; other site
703352007045	H-loop/switch region; other site
703352007046	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
703352007047	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
703352007048	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
703352007049	TM-ABC transporter signature motif; other site
703352007050	short chain dehydrogenase; Provisional; Region: PRK08219
703352007051	classical (c) SDRs; Region: SDR_c; cd05233
703352007052	NAD(P) binding site [chemical binding]; other site
703352007053	active site
703352007054	Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069
703352007055	Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782
703352007056	N- and C-terminal domain interface [polypeptide binding]; other site
703352007057	active site
703352007058	MgATP binding site [chemical binding]; other site
703352007059	catalytic site [active]
703352007060	metal binding site [ion binding]; metal-binding site
703352007061	carbohydrate binding site [chemical binding]; other site
703352007062	putative homodimer interface [polypeptide binding]; other site
703352007063	RES domain; Region: RES; smart00953
703352007064	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
703352007065	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
703352007066	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
703352007067	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
703352007068	Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901
703352007069	ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163
703352007070	4Fe-4S binding domain; Region: Fer4_5; pfam12801
703352007071	4Fe-4S binding domain; Region: Fer4_5; pfam12801
703352007072	potential frameshift: common BLAST hit: gi|376278253|ref|YP_005108286.1| nitrous-oxide reductase
703352007073	nitrous-oxide reductase; Validated; Region: PRK02888
703352007074	nitrous-oxide reductase; Validated; Region: PRK02888
703352007075	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
703352007076	Nitrous oxidase accessory protein [Inorganic ion transport and metabolism]; Region: NosD; COG3420
703352007077	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
703352007078	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
703352007079	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
703352007080	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
703352007081	Walker A/P-loop; other site
703352007082	ATP binding site [chemical binding]; other site
703352007083	Q-loop/lid; other site
703352007084	ABC transporter signature motif; other site
703352007085	Walker B; other site
703352007086	D-loop; other site
703352007087	H-loop/switch region; other site
703352007088	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
703352007089	Predicted lipoprotein involved in nitrous oxide reduction [Energy production and conversion]; Region: NosL; COG4314
703352007090	aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433
703352007091	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
703352007092	ApbE family; Region: ApbE; pfam02424
703352007093	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
703352007094	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
703352007095	ligand binding site [chemical binding]; other site
703352007096	flexible hinge region; other site
703352007097	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
703352007098	putative switch regulator; other site
703352007099	non-specific DNA interactions [nucleotide binding]; other site
703352007100	DNA binding site [nucleotide binding]
703352007101	sequence specific DNA binding site [nucleotide binding]; other site
703352007102	putative cAMP binding site [chemical binding]; other site
703352007103	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
703352007104	pseudoazurin; Region: pseudoazurin; TIGR02375
703352007105	Uncharacterized protein involved in response to NO [Inorganic ion transport and metabolism]; Region: NnrS; COG3213
703352007106	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
703352007107	NMT1-like family; Region: NMT1_2; pfam13379
703352007108	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
703352007109	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352007110	dimer interface [polypeptide binding]; other site
703352007111	conserved gate region; other site
703352007112	putative PBP binding loops; other site
703352007113	ABC-ATPase subunit interface; other site
703352007114	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
703352007115	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
703352007116	ABC transporter signature motif; other site
703352007117	Walker B; other site
703352007118	D-loop; other site
703352007119	H-loop/switch region; other site
703352007120	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
703352007121	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
703352007122	Walker A/P-loop; other site
703352007123	ATP binding site [chemical binding]; other site
703352007124	Q-loop/lid; other site
703352007125	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
703352007126	putative protease; Provisional; Region: PRK15447
703352007127	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
703352007128	Peptidase family U32; Region: Peptidase_U32; pfam01136
703352007129	Putative lipid carrier protein [Lipid metabolism]; Region: COG3154
703352007130	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
703352007131	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
703352007132	Flavoprotein; Region: Flavoprotein; pfam02441
703352007133	Protein of unknown function (DUF2478); Region: DUF2478; pfam10649
703352007134	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
703352007135	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
703352007136	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
703352007137	Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180
703352007138	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
703352007139	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
703352007140	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
703352007141	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
703352007142	[4Fe-4S] binding site [ion binding]; other site
703352007143	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
703352007144	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
703352007145	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
703352007146	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
703352007147	molybdopterin cofactor binding site; other site
703352007148	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
703352007149	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
703352007150	putative substrate translocation pore; other site
703352007151	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
703352007152	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
703352007153	transcriptional activator FtrB; Provisional; Region: ftrB; PRK09392
703352007154	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
703352007155	ligand binding site [chemical binding]; other site
703352007156	flexible hinge region; other site
703352007157	helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419
703352007158	Transcriptional regulators [Transcription]; Region: PurR; COG1609
703352007159	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
703352007160	DNA binding site [nucleotide binding]
703352007161	domain linker motif; other site
703352007162	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
703352007163	ligand binding site [chemical binding]; other site
703352007164	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
703352007165	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
703352007166	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
703352007167	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352007168	dimer interface [polypeptide binding]; other site
703352007169	conserved gate region; other site
703352007170	putative PBP binding loops; other site
703352007171	ABC-ATPase subunit interface; other site
703352007172	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
703352007173	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352007174	dimer interface [polypeptide binding]; other site
703352007175	conserved gate region; other site
703352007176	putative PBP binding loops; other site
703352007177	ABC-ATPase subunit interface; other site
703352007178	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
703352007179	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
703352007180	Walker A/P-loop; other site
703352007181	ATP binding site [chemical binding]; other site
703352007182	Q-loop/lid; other site
703352007183	ABC transporter signature motif; other site
703352007184	Walker B; other site
703352007185	D-loop; other site
703352007186	H-loop/switch region; other site
703352007187	TOBE domain; Region: TOBE_2; pfam08402
703352007188	Trehalose utilization protein [Carbohydrate transport and metabolism]; Region: ThuA; COG4813
703352007189	conserved cys residue [active]
703352007190	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
703352007191	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
703352007192	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
703352007193	Transmembrane secretion effector; Region: MFS_3; pfam05977
703352007194	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
703352007195	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
703352007196	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
703352007197	catalytic residues [active]
703352007198	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
703352007199	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
703352007200	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
703352007201	Class I ribonucleotide reductase; Region: RNR_I; cd01679
703352007202	active site
703352007203	dimer interface [polypeptide binding]; other site
703352007204	catalytic residues [active]
703352007205	effector binding site; other site
703352007206	R2 peptide binding site; other site
703352007207	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
703352007208	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
703352007209	dimer interface [polypeptide binding]; other site
703352007210	putative radical transfer pathway; other site
703352007211	diiron center [ion binding]; other site
703352007212	tyrosyl radical; other site
703352007213	septum formation inhibitor; Reviewed; Region: minC; PRK05177
703352007214	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
703352007215	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
703352007216	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
703352007217	Switch I; other site
703352007218	Switch II; other site
703352007219	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
703352007220	Domain of unknown function (DUF3597); Region: DUF3597; pfam12200
703352007221	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
703352007222	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
703352007223	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
703352007224	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
703352007225	Walker A/P-loop; other site
703352007226	ATP binding site [chemical binding]; other site
703352007227	Q-loop/lid; other site
703352007228	ABC transporter signature motif; other site
703352007229	Walker B; other site
703352007230	D-loop; other site
703352007231	H-loop/switch region; other site
703352007232	TOBE domain; Region: TOBE_2; pfam08402
703352007233	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352007234	dimer interface [polypeptide binding]; other site
703352007235	conserved gate region; other site
703352007236	putative PBP binding loops; other site
703352007237	ABC-ATPase subunit interface; other site
703352007238	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
703352007239	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352007240	dimer interface [polypeptide binding]; other site
703352007241	conserved gate region; other site
703352007242	putative PBP binding loops; other site
703352007243	ABC-ATPase subunit interface; other site
703352007244	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
703352007245	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
703352007246	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
703352007247	HlyD family secretion protein; Region: HlyD_3; pfam13437
703352007248	Predicted membrane protein [Function unknown]; Region: COG4803
703352007249	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
703352007250	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
703352007251	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
703352007252	catalytic residue [active]
703352007253	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
703352007254	Glutaminase; Region: Glutaminase; cl00907
703352007255	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
703352007256	Glutaminase; Region: Glutaminase; cl00907
703352007257	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
703352007258	acid-resistance protein; Provisional; Region: PRK10208
703352007259	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
703352007260	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
703352007261	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
703352007262	Transcriptional regulator [Transcription]; Region: LysR; COG0583
703352007263	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
703352007264	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
703352007265	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
703352007266	Substrate binding site; other site
703352007267	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
703352007268	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
703352007269	ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088
703352007270	active site
703352007271	substrate binding site [chemical binding]; other site
703352007272	metal binding site [ion binding]; metal-binding site
703352007273	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
703352007274	putative active site pocket [active]
703352007275	cleavage site
703352007276	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
703352007277	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
703352007278	putative ion selectivity filter; other site
703352007279	putative pore gating glutamate residue; other site
703352007280	putative H+/Cl- coupling transport residue; other site
703352007281	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
703352007282	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
703352007283	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
703352007284	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
703352007285	active site
703352007286	Cytochrome c [Energy production and conversion]; Region: COG3258
703352007287	Cytochrome c; Region: Cytochrom_C; pfam00034
703352007288	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
703352007289	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
703352007290	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
703352007291	dimerization interface [polypeptide binding]; other site
703352007292	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
703352007293	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
703352007294	tetramer interface [polypeptide binding]; other site
703352007295	heme binding pocket [chemical binding]; other site
703352007296	NADPH binding site [chemical binding]; other site
703352007297	Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495
703352007298	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
703352007299	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
703352007300	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
703352007301	CoenzymeA binding site [chemical binding]; other site
703352007302	subunit interaction site [polypeptide binding]; other site
703352007303	PHB binding site; other site
703352007304	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06026
703352007305	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, putative; Region: MTA/SAH-nuc-hyp; TIGR01705
703352007306	GMP synthase; Reviewed; Region: guaA; PRK00074
703352007307	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
703352007308	AMP/PPi binding site [chemical binding]; other site
703352007309	candidate oxyanion hole; other site
703352007310	catalytic triad [active]
703352007311	potential glutamine specificity residues [chemical binding]; other site
703352007312	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
703352007313	ATP Binding subdomain [chemical binding]; other site
703352007314	Ligand Binding sites [chemical binding]; other site
703352007315	Dimerization subdomain; other site
703352007316	Uncharacterized protein probably involved in high-affinity Fe2+ transport [Inorganic ion transport and metabolism]; Region: Tpd; COG3470
703352007317	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
703352007318	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
703352007319	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
703352007320	4Fe-4S binding domain; Region: Fer4_5; pfam12801
703352007321	putative phosphoketolase; Provisional; Region: PRK05261
703352007322	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
703352007323	TPP-binding site; other site
703352007324	XFP C-terminal domain; Region: XFP_C; pfam09363
703352007325	acetate kinase; Provisional; Region: PRK07058
703352007326	propionate/acetate kinase; Provisional; Region: PRK12379
703352007327	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
703352007328	Cytochrome P450; Region: p450; cl12078
703352007329	Transcriptional regulators [Transcription]; Region: GntR; COG1802
703352007330	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
703352007331	DNA-binding site [nucleotide binding]; DNA binding site
703352007332	FCD domain; Region: FCD; pfam07729
703352007333	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
703352007334	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
703352007335	NAD(P) binding site [chemical binding]; other site
703352007336	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
703352007337	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
703352007338	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
703352007339	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
703352007340	TM-ABC transporter signature motif; other site
703352007341	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
703352007342	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
703352007343	TM-ABC transporter signature motif; other site
703352007344	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
703352007345	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
703352007346	Walker A/P-loop; other site
703352007347	ATP binding site [chemical binding]; other site
703352007348	Q-loop/lid; other site
703352007349	ABC transporter signature motif; other site
703352007350	Walker B; other site
703352007351	D-loop; other site
703352007352	H-loop/switch region; other site
703352007353	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
703352007354	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
703352007355	Walker A/P-loop; other site
703352007356	ATP binding site [chemical binding]; other site
703352007357	Q-loop/lid; other site
703352007358	ABC transporter signature motif; other site
703352007359	Walker B; other site
703352007360	D-loop; other site
703352007361	H-loop/switch region; other site
703352007362	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
703352007363	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
703352007364	NAD(P) binding site [chemical binding]; other site
703352007365	active site
703352007366	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
703352007367	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
703352007368	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
703352007369	shikimate binding site; other site
703352007370	NAD(P) binding site [chemical binding]; other site
703352007371	choline dehydrogenase; Validated; Region: PRK02106
703352007372	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
703352007373	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
703352007374	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
703352007375	tetramerization interface [polypeptide binding]; other site
703352007376	NAD(P) binding site [chemical binding]; other site
703352007377	catalytic residues [active]
703352007378	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
703352007379	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
703352007380	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
703352007381	Zinc-dependent alcohol dehydrogenases (ADH) and class III ADG (AKA formaldehyde dehydrogenase); Region: liver_ADH_like1; cd08281
703352007382	NAD binding site [chemical binding]; other site
703352007383	catalytic Zn binding site [ion binding]; other site
703352007384	substrate binding site [chemical binding]; other site
703352007385	structural Zn binding site [ion binding]; other site
703352007386	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
703352007387	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
703352007388	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
703352007389	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
703352007390	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
703352007391	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
703352007392	Walker A/P-loop; other site
703352007393	ATP binding site [chemical binding]; other site
703352007394	Q-loop/lid; other site
703352007395	ABC transporter signature motif; other site
703352007396	Walker B; other site
703352007397	D-loop; other site
703352007398	H-loop/switch region; other site
703352007399	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
703352007400	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
703352007401	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
703352007402	Walker A/P-loop; other site
703352007403	ATP binding site [chemical binding]; other site
703352007404	Q-loop/lid; other site
703352007405	ABC transporter signature motif; other site
703352007406	Walker B; other site
703352007407	D-loop; other site
703352007408	H-loop/switch region; other site
703352007409	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
703352007410	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
703352007411	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
703352007412	inhibitor site; inhibition site
703352007413	active site
703352007414	dimer interface [polypeptide binding]; other site
703352007415	catalytic residue [active]
703352007416	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
703352007417	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352007418	dimer interface [polypeptide binding]; other site
703352007419	conserved gate region; other site
703352007420	putative PBP binding loops; other site
703352007421	ABC-ATPase subunit interface; other site
703352007422	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
703352007423	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352007424	dimer interface [polypeptide binding]; other site
703352007425	conserved gate region; other site
703352007426	putative PBP binding loops; other site
703352007427	ABC-ATPase subunit interface; other site
703352007428	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
703352007429	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
703352007430	Transcriptional regulators [Transcription]; Region: FadR; COG2186
703352007431	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
703352007432	DNA-binding site [nucleotide binding]; DNA binding site
703352007433	FCD domain; Region: FCD; pfam07729
703352007434	Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010
703352007435	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
703352007436	putative active site cavity [active]
703352007437	N-acetylmannosamine kinase; Provisional; Region: PRK05082
703352007438	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
703352007439	nucleotide binding site [chemical binding]; other site
703352007440	N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131
703352007441	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
703352007442	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
703352007443	ligand binding site [chemical binding]; other site
703352007444	flexible hinge region; other site
703352007445	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
703352007446	putative switch regulator; other site
703352007447	non-specific DNA interactions [nucleotide binding]; other site
703352007448	DNA binding site [nucleotide binding]
703352007449	sequence specific DNA binding site [nucleotide binding]; other site
703352007450	putative cAMP binding site [chemical binding]; other site
703352007451	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
703352007452	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
703352007453	DNA binding residues [nucleotide binding]
703352007454	dimerization interface [polypeptide binding]; other site
703352007455	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
703352007456	Chain length determinant protein; Region: Wzz; cl15801
703352007457	AAA domain; Region: AAA_31; pfam13614
703352007458	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
703352007459	G3 box; other site
703352007460	Switch II region; other site
703352007461	G4 box; other site
703352007462	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
703352007463	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
703352007464	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
703352007465	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
703352007466	NAD(P) binding site [chemical binding]; other site
703352007467	active site
703352007468	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
703352007469	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
703352007470	NADP-binding site; other site
703352007471	homotetramer interface [polypeptide binding]; other site
703352007472	substrate binding site [chemical binding]; other site
703352007473	homodimer interface [polypeptide binding]; other site
703352007474	active site
703352007475	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
703352007476	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
703352007477	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
703352007478	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
703352007479	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
703352007480	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
703352007481	putative ADP-binding pocket [chemical binding]; other site
703352007482	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
703352007483	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
703352007484	putative trimer interface [polypeptide binding]; other site
703352007485	putative active site [active]
703352007486	putative substrate binding site [chemical binding]; other site
703352007487	putative CoA binding site [chemical binding]; other site
703352007488	Uncharacterized conserved protein [Function unknown]; Region: COG1434
703352007489	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
703352007490	putative active site [active]
703352007491	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
703352007492	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
703352007493	putative metal binding site; other site
703352007494	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
703352007495	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
703352007496	Mg++ binding site [ion binding]; other site
703352007497	putative catalytic motif [active]
703352007498	substrate binding site [chemical binding]; other site
703352007499	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
703352007500	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
703352007501	potential frameshift: common BLAST hit: gi|376278402|ref|YP_005108435.1| glycosyl transferase, group 2 family protein
703352007502	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
703352007503	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
703352007504	active site
703352007505	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
703352007506	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
703352007507	potential frameshift: common BLAST hit: gi|376276860|ref|YP_005152921.1| glycoside hydrolase family protein
703352007508	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
703352007509	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
703352007510	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
703352007511	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
703352007512	glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209
703352007513	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
703352007514	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
703352007515	catalytic residue [active]
703352007516	Protein of unknown function (DUF4038); Region: DUF4038; pfam13204
703352007517	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
703352007518	extended (e) SDRs; Region: SDR_e; cd08946
703352007519	NAD(P) binding site [chemical binding]; other site
703352007520	active site
703352007521	substrate binding site [chemical binding]; other site
703352007522	Uncharacterized protein conserved in bacteria with an aminopeptidase-like domain [General function prediction only]; Region: COG4310
703352007523	M28 Zn-Peptidases; Region: M28_like_3; cd05644
703352007524	active site
703352007525	metal binding site [ion binding]; metal-binding site
703352007526	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
703352007527	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
703352007528	Methyltransferase domain; Region: Methyltransf_23; pfam13489
703352007529	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
703352007530	S-adenosylmethionine binding site [chemical binding]; other site
703352007531	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
703352007532	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
703352007533	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
703352007534	active site
703352007535	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
703352007536	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
703352007537	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
703352007538	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
703352007539	nucleotide binding site [chemical binding]; other site
703352007540	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
703352007541	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
703352007542	Major Facilitator Superfamily; Region: MFS_1; pfam07690
703352007543	putative substrate translocation pore; other site
703352007544	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
703352007545	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
703352007546	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
703352007547	putative dimerization interface [polypeptide binding]; other site
703352007548	putative substrate binding pocket [chemical binding]; other site
703352007549	methionine sulfoxide reductase B; Provisional; Region: PRK00222
703352007550	SelR domain; Region: SelR; pfam01641
703352007551	cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207
703352007552	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
703352007553	active site
703352007554	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
703352007555	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
703352007556	dimer interface [polypeptide binding]; other site
703352007557	active site
703352007558	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
703352007559	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
703352007560	NAD binding site [chemical binding]; other site
703352007561	homodimer interface [polypeptide binding]; other site
703352007562	homotetramer interface [polypeptide binding]; other site
703352007563	active site
703352007564	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
703352007565	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
703352007566	active site
703352007567	CoA binding site [chemical binding]; other site
703352007568	AMP binding site [chemical binding]; other site
703352007569	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
703352007570	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
703352007571	acyl-activating enzyme (AAE) consensus motif; other site
703352007572	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
703352007573	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
703352007574	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
703352007575	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
703352007576	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
703352007577	ligand binding site [chemical binding]; other site
703352007578	NAD binding site [chemical binding]; other site
703352007579	tetramer interface [polypeptide binding]; other site
703352007580	catalytic site [active]
703352007581	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
703352007582	L-serine binding site [chemical binding]; other site
703352007583	ACT domain interface; other site
703352007584	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
703352007585	active site
703352007586	catalytic residues [active]
703352007587	metal binding site [ion binding]; metal-binding site
703352007588	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354
703352007589	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
703352007590	dimerization interface [polypeptide binding]; other site
703352007591	putative DNA binding site [nucleotide binding]; other site
703352007592	putative Zn2+ binding site [ion binding]; other site
703352007593	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
703352007594	Predicted transporter component [General function prediction only]; Region: COG2391
703352007595	Predicted transporter component [General function prediction only]; Region: COG2391
703352007596	Sulphur transport; Region: Sulf_transp; pfam04143
703352007597	Transcriptional regulators [Transcription]; Region: GntR; COG1802
703352007598	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
703352007599	DNA-binding site [nucleotide binding]; DNA binding site
703352007600	FCD domain; Region: FCD; pfam07729
703352007601	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
703352007602	Domain of unknown function DUF20; Region: UPF0118; pfam01594
703352007603	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552
703352007604	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
703352007605	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
703352007606	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
703352007607	Peptidase family M23; Region: Peptidase_M23; pfam01551
703352007608	HlyD family secretion protein; Region: HlyD_3; pfam13437
703352007609	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
703352007610	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
703352007611	Walker A/P-loop; other site
703352007612	ATP binding site [chemical binding]; other site
703352007613	Q-loop/lid; other site
703352007614	ABC transporter signature motif; other site
703352007615	Walker B; other site
703352007616	D-loop; other site
703352007617	H-loop/switch region; other site
703352007618	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
703352007619	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
703352007620	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
703352007621	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
703352007622	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
703352007623	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352007624	dimer interface [polypeptide binding]; other site
703352007625	conserved gate region; other site
703352007626	putative PBP binding loops; other site
703352007627	ABC-ATPase subunit interface; other site
703352007628	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
703352007629	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
703352007630	Walker A/P-loop; other site
703352007631	ATP binding site [chemical binding]; other site
703352007632	Q-loop/lid; other site
703352007633	ABC transporter signature motif; other site
703352007634	Walker B; other site
703352007635	D-loop; other site
703352007636	H-loop/switch region; other site
703352007637	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
703352007638	NMT1/THI5 like; Region: NMT1; pfam09084
703352007639	substrate binding pocket [chemical binding]; other site
703352007640	membrane-bound complex binding site; other site
703352007641	hinge residues; other site
703352007642	MarR family; Region: MarR_2; pfam12802
703352007643	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
703352007644	Major Facilitator Superfamily; Region: MFS_1; pfam07690
703352007645	putative substrate translocation pore; other site
703352007646	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
703352007647	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
703352007648	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
703352007649	HlyD family secretion protein; Region: HlyD_3; pfam13437
703352007650	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
703352007651	HAMP domain; Region: HAMP; pfam00672
703352007652	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
703352007653	dimer interface [polypeptide binding]; other site
703352007654	phosphorylation site [posttranslational modification]
703352007655	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
703352007656	ATP binding site [chemical binding]; other site
703352007657	Mg2+ binding site [ion binding]; other site
703352007658	G-X-G motif; other site
703352007659	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
703352007660	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
703352007661	active site
703352007662	phosphorylation site [posttranslational modification]
703352007663	intermolecular recognition site; other site
703352007664	dimerization interface [polypeptide binding]; other site
703352007665	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
703352007666	DNA binding site [nucleotide binding]
703352007667	Uncharacterized conserved protein [Function unknown]; Region: COG3189
703352007668	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
703352007669	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
703352007670	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
703352007671	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
703352007672	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
703352007673	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
703352007674	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
703352007675	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
703352007676	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
703352007677	Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235
703352007678	potential frameshift: common BLAST hit: gi|376276807|ref|YP_005152868.1| glycosyl hydrolase family protein
703352007679	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
703352007680	active site
703352007681	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
703352007682	Homoserine trans-succinylase [Amino acid transport and metabolism]; Region: MetA; COG1897
703352007683	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
703352007684	proposed active site lysine [active]
703352007685	conserved cys residue [active]
703352007686	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05963
703352007687	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
703352007688	dimer interface [polypeptide binding]; other site
703352007689	active site
703352007690	CoA binding pocket [chemical binding]; other site
703352007691	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
703352007692	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
703352007693	inhibitor-cofactor binding pocket; inhibition site
703352007694	pyridoxal 5'-phosphate binding site [chemical binding]; other site
703352007695	catalytic residue [active]
703352007696	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
703352007697	AAA domain; Region: AAA_26; pfam13500
703352007698	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
703352007699	hypothetical protein; Provisional; Region: PRK07505
703352007700	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
703352007701	catalytic residue [active]
703352007702	biotin synthase; Region: bioB; TIGR00433
703352007703	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
703352007704	FeS/SAM binding site; other site
703352007705	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
703352007706	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
703352007707	MPT binding site; other site
703352007708	trimer interface [polypeptide binding]; other site
703352007709	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
703352007710	dimer interface [polypeptide binding]; other site
703352007711	FMN binding site [chemical binding]; other site
703352007712	potential frameshift: common BLAST hit: gi|376271280|ref|YP_005114325.1| hydroxyacylglutathione hydrolase
703352007713	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
703352007714	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
703352007715	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
703352007716	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
703352007717	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
703352007718	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
703352007719	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
703352007720	monovalent cation:proton antiporter; Region: 2a6301s02; TIGR00943
703352007721	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094
703352007722	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
703352007723	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
703352007724	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12596
703352007725	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161
703352007726	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12671
703352007727	Predicted transcriptional regulators [Transcription]; Region: COG1510
703352007728	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
703352007729	dimerization interface [polypeptide binding]; other site
703352007730	putative DNA binding site [nucleotide binding]; other site
703352007731	putative Zn2+ binding site [ion binding]; other site
703352007732	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
703352007733	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
703352007734	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
703352007735	Walker A/P-loop; other site
703352007736	ATP binding site [chemical binding]; other site
703352007737	Q-loop/lid; other site
703352007738	ABC transporter signature motif; other site
703352007739	Walker B; other site
703352007740	D-loop; other site
703352007741	H-loop/switch region; other site
703352007742	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
703352007743	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
703352007744	Walker A/P-loop; other site
703352007745	ATP binding site [chemical binding]; other site
703352007746	Q-loop/lid; other site
703352007747	ABC transporter signature motif; other site
703352007748	Walker B; other site
703352007749	D-loop; other site
703352007750	H-loop/switch region; other site
703352007751	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
703352007752	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
703352007753	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
703352007754	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
703352007755	Predicted outer membrane lipoprotein [Function unknown]; Region: COG4890
703352007756	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
703352007757	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
703352007758	DNA-binding site [nucleotide binding]; DNA binding site
703352007759	UTRA domain; Region: UTRA; pfam07702
703352007760	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
703352007761	nucleotide binding site [chemical binding]; other site
703352007762	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
703352007763	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
703352007764	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
703352007765	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
703352007766	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
703352007767	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352007768	dimer interface [polypeptide binding]; other site
703352007769	conserved gate region; other site
703352007770	putative PBP binding loops; other site
703352007771	ABC-ATPase subunit interface; other site
703352007772	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
703352007773	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352007774	dimer interface [polypeptide binding]; other site
703352007775	conserved gate region; other site
703352007776	putative PBP binding loops; other site
703352007777	ABC-ATPase subunit interface; other site
703352007778	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
703352007779	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
703352007780	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
703352007781	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
703352007782	Walker A/P-loop; other site
703352007783	ATP binding site [chemical binding]; other site
703352007784	Q-loop/lid; other site
703352007785	ABC transporter signature motif; other site
703352007786	Walker B; other site
703352007787	D-loop; other site
703352007788	H-loop/switch region; other site
703352007789	TOBE domain; Region: TOBE_2; pfam08402
703352007790	2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573
703352007791	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
703352007792	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
703352007793	tetramer interface [polypeptide binding]; other site
703352007794	TPP-binding site [chemical binding]; other site
703352007795	heterodimer interface [polypeptide binding]; other site
703352007796	phosphorylation loop region [posttranslational modification]
703352007797	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
703352007798	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
703352007799	alpha subunit interface [polypeptide binding]; other site
703352007800	TPP binding site [chemical binding]; other site
703352007801	heterodimer interface [polypeptide binding]; other site
703352007802	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
703352007803	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
703352007804	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
703352007805	E3 interaction surface; other site
703352007806	lipoyl attachment site [posttranslational modification]; other site
703352007807	e3 binding domain; Region: E3_binding; pfam02817
703352007808	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
703352007809	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
703352007810	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
703352007811	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
703352007812	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
703352007813	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
703352007814	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
703352007815	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
703352007816	L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253
703352007817	homodimer interface [polypeptide binding]; other site
703352007818	homotetramer interface [polypeptide binding]; other site
703352007819	active site pocket [active]
703352007820	cleavage site
703352007821	benzoate transport; Region: 2A0115; TIGR00895
703352007822	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
703352007823	putative substrate translocation pore; other site
703352007824	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
703352007825	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
703352007826	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
703352007827	Walker A/P-loop; other site
703352007828	ATP binding site [chemical binding]; other site
703352007829	Q-loop/lid; other site
703352007830	ABC transporter signature motif; other site
703352007831	Walker B; other site
703352007832	D-loop; other site
703352007833	H-loop/switch region; other site
703352007834	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
703352007835	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
703352007836	Walker A/P-loop; other site
703352007837	ATP binding site [chemical binding]; other site
703352007838	Q-loop/lid; other site
703352007839	ABC transporter signature motif; other site
703352007840	Walker B; other site
703352007841	D-loop; other site
703352007842	H-loop/switch region; other site
703352007843	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
703352007844	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
703352007845	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352007846	dimer interface [polypeptide binding]; other site
703352007847	conserved gate region; other site
703352007848	ABC-ATPase subunit interface; other site
703352007849	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
703352007850	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352007851	dimer interface [polypeptide binding]; other site
703352007852	conserved gate region; other site
703352007853	putative PBP binding loops; other site
703352007854	ABC-ATPase subunit interface; other site
703352007855	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
703352007856	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
703352007857	peptide binding site [polypeptide binding]; other site
703352007858	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
703352007859	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
703352007860	peptide binding site [polypeptide binding]; other site
703352007861	Predicted integral membrane protein [Function unknown]; Region: COG5455
703352007862	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
703352007863	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
703352007864	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
703352007865	NAD binding site [chemical binding]; other site
703352007866	homodimer interface [polypeptide binding]; other site
703352007867	active site
703352007868	substrate binding site [chemical binding]; other site
703352007869	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
703352007870	active site
703352007871	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
703352007872	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
703352007873	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
703352007874	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
703352007875	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
703352007876	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
703352007877	Protein of unknown function (DUF995); Region: DUF995; pfam06191
703352007878	Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124
703352007879	Protein of unknown function (DUF995); Region: DUF995; pfam06191
703352007880	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
703352007881	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
703352007882	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
703352007883	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
703352007884	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
703352007885	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
703352007886	yecA family protein; Region: ygfB_yecA; TIGR02292
703352007887	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
703352007888	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
703352007889	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
703352007890	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
703352007891	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
703352007892	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
703352007893	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
703352007894	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
703352007895	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
703352007896	putative deacylase active site [active]
703352007897	iron-responsive transcriptional regulator; Reviewed; Region: rirA; PRK11920
703352007898	Predicted transcriptional regulator [Transcription]; Region: COG1959
703352007899	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
703352007900	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
703352007901	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
703352007902	heme binding site [chemical binding]; other site
703352007903	ferroxidase pore; other site
703352007904	ferroxidase diiron center [ion binding]; other site
703352007905	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
703352007906	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
703352007907	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
703352007908	FeS/SAM binding site; other site
703352007909	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
703352007910	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
703352007911	putative ligand binding site [chemical binding]; other site
703352007912	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
703352007913	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
703352007914	TM-ABC transporter signature motif; other site
703352007915	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
703352007916	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
703352007917	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
703352007918	TM-ABC transporter signature motif; other site
703352007919	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
703352007920	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
703352007921	Walker A/P-loop; other site
703352007922	ATP binding site [chemical binding]; other site
703352007923	Q-loop/lid; other site
703352007924	ABC transporter signature motif; other site
703352007925	Walker B; other site
703352007926	D-loop; other site
703352007927	H-loop/switch region; other site
703352007928	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
703352007929	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
703352007930	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
703352007931	NADP binding site [chemical binding]; other site
703352007932	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
703352007933	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
703352007934	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494
703352007935	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
703352007936	Uncharacterized conserved protein [Function unknown]; Region: COG3785
703352007937	Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342
703352007938	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
703352007939	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
703352007940	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
703352007941	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
703352007942	catalytic residues [active]
703352007943	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
703352007944	fosfomycin resistance protein FosB; Provisional; Region: PRK04101
703352007945	active site
703352007946	metal binding site [ion binding]; metal-binding site
703352007947	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
703352007948	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
703352007949	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
703352007950	ATP binding site [chemical binding]; other site
703352007951	putative Mg++ binding site [ion binding]; other site
703352007952	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
703352007953	nucleotide binding region [chemical binding]; other site
703352007954	ATP-binding site [chemical binding]; other site
703352007955	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
703352007956	Uncharacterized conserved protein [Function unknown]; Region: COG2938
703352007957	RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200
703352007958	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
703352007959	generic binding surface II; other site
703352007960	ssDNA binding site; other site
703352007961	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
703352007962	ATP binding site [chemical binding]; other site
703352007963	putative Mg++ binding site [ion binding]; other site
703352007964	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
703352007965	nucleotide binding region [chemical binding]; other site
703352007966	ATP-binding site [chemical binding]; other site
703352007967	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
703352007968	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
703352007969	glutaminase active site [active]
703352007970	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
703352007971	dimer interface [polypeptide binding]; other site
703352007972	active site
703352007973	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
703352007974	dimer interface [polypeptide binding]; other site
703352007975	active site
703352007976	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353
703352007977	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
703352007978	Substrate binding site; other site
703352007979	Mg++ binding site; other site
703352007980	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
703352007981	active site
703352007982	substrate binding site [chemical binding]; other site
703352007983	CoA binding site [chemical binding]; other site
703352007984	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
703352007985	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
703352007986	Predicted integral membrane protein [Function unknown]; Region: COG0392
703352007987	Uncharacterized conserved protein [Function unknown]; Region: COG2898
703352007988	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
703352007989	Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946
703352007990	Bacterial virulence protein (VirJ); Region: VirJ; pfam06057
703352007991	BA14K-like protein; Region: BA14K; pfam07886
703352007992	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
703352007993	PAS domain; Region: PAS_9; pfam13426
703352007994	putative active site [active]
703352007995	heme pocket [chemical binding]; other site
703352007996	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
703352007997	PAS fold; Region: PAS_3; pfam08447
703352007998	putative active site [active]
703352007999	heme pocket [chemical binding]; other site
703352008000	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
703352008001	HWE histidine kinase; Region: HWE_HK; pfam07536
703352008002	lipoate-protein ligase B; Provisional; Region: PRK14341
703352008003	EamA-like transporter family; Region: EamA; pfam00892
703352008004	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
703352008005	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
703352008006	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
703352008007	Mg2+ binding site [ion binding]; other site
703352008008	G-X-G motif; other site
703352008009	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
703352008010	anchoring element; other site
703352008011	dimer interface [polypeptide binding]; other site
703352008012	ATP binding site [chemical binding]; other site
703352008013	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
703352008014	active site
703352008015	metal binding site [ion binding]; metal-binding site
703352008016	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
703352008017	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
703352008018	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
703352008019	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
703352008020	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
703352008021	metal-dependent hydrolase; Provisional; Region: PRK00685
703352008022	Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816
703352008023	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
703352008024	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
703352008025	active site
703352008026	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
703352008027	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
703352008028	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
703352008029	dihydroorotase; Validated; Region: PRK09059
703352008030	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
703352008031	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
703352008032	active site
703352008033	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
703352008034	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
703352008035	DNA protecting protein DprA; Region: dprA; TIGR00732
703352008036	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
703352008037	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
703352008038	active site
703352008039	interdomain interaction site; other site
703352008040	putative metal-binding site [ion binding]; other site
703352008041	nucleotide binding site [chemical binding]; other site
703352008042	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
703352008043	domain I; other site
703352008044	DNA binding groove [nucleotide binding]
703352008045	phosphate binding site [ion binding]; other site
703352008046	domain II; other site
703352008047	domain III; other site
703352008048	nucleotide binding site [chemical binding]; other site
703352008049	catalytic site [active]
703352008050	domain IV; other site
703352008051	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
703352008052	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
703352008053	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
703352008054	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
703352008055	ribonuclease R; Region: RNase_R; TIGR02063
703352008056	RNB domain; Region: RNB; pfam00773
703352008057	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
703352008058	RNA binding site [nucleotide binding]; other site
703352008059	hypothetical protein; Provisional; Region: PRK05978
703352008060	NUDIX domain; Region: NUDIX; pfam00293
703352008061	nudix motif; other site
703352008062	Major Facilitator Superfamily; Region: MFS_1; pfam07690
703352008063	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
703352008064	putative substrate translocation pore; other site
703352008065	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
703352008066	response regulator PleD; Reviewed; Region: pleD; PRK09581
703352008067	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
703352008068	active site
703352008069	phosphorylation site [posttranslational modification]
703352008070	intermolecular recognition site; other site
703352008071	dimerization interface [polypeptide binding]; other site
703352008072	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
703352008073	active site
703352008074	phosphorylation site [posttranslational modification]
703352008075	intermolecular recognition site; other site
703352008076	dimerization interface [polypeptide binding]; other site
703352008077	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
703352008078	metal binding site [ion binding]; metal-binding site
703352008079	active site
703352008080	I-site; other site
703352008081	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
703352008082	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
703352008083	active site
703352008084	phosphorylation site [posttranslational modification]
703352008085	intermolecular recognition site; other site
703352008086	dimerization interface [polypeptide binding]; other site
703352008087	Protein of unknown function (DUF3572); Region: DUF3572; pfam12096
703352008088	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
703352008089	DNA polymerase IV; Provisional; Region: PRK02794
703352008090	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
703352008091	active site
703352008092	DNA binding site [nucleotide binding]
703352008093	Uncharacterized conserved protein [Function unknown]; Region: COG3391
703352008094	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
703352008095	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
703352008096	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
703352008097	metal binding site [ion binding]; metal-binding site
703352008098	active site
703352008099	I-site; other site
703352008100	Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013
703352008101	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
703352008102	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
703352008103	active site
703352008104	catalytic site [active]
703352008105	substrate binding site [chemical binding]; other site
703352008106	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
703352008107	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
703352008108	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
703352008109	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
703352008110	hydroxyglutarate oxidase; Provisional; Region: PRK11728
703352008111	hydroxyglutarate oxidase; Provisional; Region: PRK11728
703352008112	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
703352008113	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
703352008114	membrane-bound complex binding site; other site
703352008115	hinge residues; other site
703352008116	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
703352008117	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
703352008118	substrate binding pocket [chemical binding]; other site
703352008119	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
703352008120	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
703352008121	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
703352008122	putative DNA binding site [nucleotide binding]; other site
703352008123	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
703352008124	putative Zn2+ binding site [ion binding]; other site
703352008125	AsnC family; Region: AsnC_trans_reg; pfam01037
703352008126	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
703352008127	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
703352008128	active site
703352008129	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
703352008130	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
703352008131	dimer interface [polypeptide binding]; other site
703352008132	active site
703352008133	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
703352008134	Coenzyme A transferase; Region: CoA_trans; cl17247
703352008135	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
703352008136	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
703352008137	Bacterial transcriptional regulator; Region: IclR; pfam01614
703352008138	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
703352008139	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
703352008140	Cupin domain; Region: Cupin_2; cl17218
703352008141	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
703352008142	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
703352008143	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
703352008144	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
703352008145	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
703352008146	dimerization interface [polypeptide binding]; other site
703352008147	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
703352008148	4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425
703352008149	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
703352008150	active site
703352008151	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
703352008152	Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463
703352008153	heterodimer interface [polypeptide binding]; other site
703352008154	active site
703352008155	3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK05975
703352008156	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
703352008157	tetramer interface [polypeptide binding]; other site
703352008158	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
703352008159	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
703352008160	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
703352008161	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
703352008162	TM-ABC transporter signature motif; other site
703352008163	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
703352008164	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
703352008165	TM-ABC transporter signature motif; other site
703352008166	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
703352008167	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
703352008168	Walker A/P-loop; other site
703352008169	ATP binding site [chemical binding]; other site
703352008170	Q-loop/lid; other site
703352008171	ABC transporter signature motif; other site
703352008172	Walker B; other site
703352008173	D-loop; other site
703352008174	H-loop/switch region; other site
703352008175	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
703352008176	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
703352008177	Walker A/P-loop; other site
703352008178	ATP binding site [chemical binding]; other site
703352008179	Q-loop/lid; other site
703352008180	ABC transporter signature motif; other site
703352008181	Walker B; other site
703352008182	D-loop; other site
703352008183	H-loop/switch region; other site
703352008184	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
703352008185	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
703352008186	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
703352008187	active site
703352008188	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
703352008189	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
703352008190	active site
703352008191	dimer interface [polypeptide binding]; other site
703352008192	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
703352008193	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
703352008194	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
703352008195	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
703352008196	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
703352008197	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352008198	dimer interface [polypeptide binding]; other site
703352008199	conserved gate region; other site
703352008200	ABC-ATPase subunit interface; other site
703352008201	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
703352008202	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
703352008203	Walker A/P-loop; other site
703352008204	ATP binding site [chemical binding]; other site
703352008205	Q-loop/lid; other site
703352008206	ABC transporter signature motif; other site
703352008207	Walker B; other site
703352008208	D-loop; other site
703352008209	H-loop/switch region; other site
703352008210	TOBE domain; Region: TOBE_2; pfam08402
703352008211	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
703352008212	transmembrane helices; other site
703352008213	TrkA-C domain; Region: TrkA_C; pfam02080
703352008214	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
703352008215	TrkA-C domain; Region: TrkA_C; pfam02080
703352008216	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
703352008217	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
703352008218	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
703352008219	nucleoside/Zn binding site; other site
703352008220	dimer interface [polypeptide binding]; other site
703352008221	catalytic motif [active]
703352008222	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
703352008223	Protein of unknown function (DUF2938); Region: DUF2938; pfam11158
703352008224	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
703352008225	EamA-like transporter family; Region: EamA; pfam00892
703352008226	aminotransferase; Provisional; Region: PRK13356
703352008227	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
703352008228	homodimer interface [polypeptide binding]; other site
703352008229	substrate-cofactor binding pocket; other site
703352008230	pyridoxal 5'-phosphate binding site [chemical binding]; other site
703352008231	catalytic residue [active]
703352008232	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
703352008233	potential frameshift: common BLAST hit: gi|376271119|ref|YP_005114164.1| FAD-binding dehydrogenase
703352008234	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
703352008235	FAD binding domain; Region: FAD_binding_2; pfam00890
703352008236	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
703352008237	Protein of unknown function (DUF3775); Region: DUF3775; pfam12616
703352008238	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
703352008239	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
703352008240	NAD binding site [chemical binding]; other site
703352008241	catalytic residues [active]
703352008242	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
703352008243	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
703352008244	putative ligand binding residues [chemical binding]; other site
703352008245	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
703352008246	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
703352008247	ABC-ATPase subunit  interface; other site
703352008248	dimer interface [polypeptide binding]; other site
703352008249	putative PBP binding regions; other site
703352008250	ABC-type enterochelin transport system, permease component [Inorganic ion transport and metabolism]; Region: CeuC; COG4605
703352008251	ABC-ATPase subunit  interface; other site
703352008252	dimer interface [polypeptide binding]; other site
703352008253	putative PBP binding regions; other site
703352008254	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
703352008255	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
703352008256	Walker A/P-loop; other site
703352008257	ATP binding site [chemical binding]; other site
703352008258	Q-loop/lid; other site
703352008259	ABC transporter signature motif; other site
703352008260	Walker B; other site
703352008261	D-loop; other site
703352008262	H-loop/switch region; other site
703352008263	Predicted transcription regulator, contains HTH domain (MarR family) [Transcription]; Region: COG5631
703352008264	5-oxoprolinase; Region: PLN02666
703352008265	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
703352008266	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
703352008267	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
703352008268	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
703352008269	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
703352008270	substrate binding pocket [chemical binding]; other site
703352008271	membrane-bound complex binding site; other site
703352008272	hinge residues; other site
703352008273	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352008274	dimer interface [polypeptide binding]; other site
703352008275	conserved gate region; other site
703352008276	putative PBP binding loops; other site
703352008277	ABC-ATPase subunit interface; other site
703352008278	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
703352008279	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
703352008280	Walker A/P-loop; other site
703352008281	ATP binding site [chemical binding]; other site
703352008282	Q-loop/lid; other site
703352008283	ABC transporter signature motif; other site
703352008284	Walker B; other site
703352008285	D-loop; other site
703352008286	H-loop/switch region; other site
703352008287	exopolyphosphatase; Region: exo_poly_only; TIGR03706
703352008288	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
703352008289	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
703352008290	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
703352008291	S-adenosylmethionine binding site [chemical binding]; other site
703352008292	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
703352008293	putative transporter; Provisional; Region: PRK10504
703352008294	putative substrate translocation pore; other site
703352008295	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
703352008296	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
703352008297	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
703352008298	Walker A/P-loop; other site
703352008299	ATP binding site [chemical binding]; other site
703352008300	Q-loop/lid; other site
703352008301	ABC transporter signature motif; other site
703352008302	Walker B; other site
703352008303	D-loop; other site
703352008304	H-loop/switch region; other site
703352008305	TOBE domain; Region: TOBE_2; pfam08402
703352008306	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
703352008307	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352008308	dimer interface [polypeptide binding]; other site
703352008309	conserved gate region; other site
703352008310	putative PBP binding loops; other site
703352008311	ABC-ATPase subunit interface; other site
703352008312	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352008313	dimer interface [polypeptide binding]; other site
703352008314	conserved gate region; other site
703352008315	putative PBP binding loops; other site
703352008316	ABC-ATPase subunit interface; other site
703352008317	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
703352008318	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
703352008319	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-II; Region: Lumazine_synthase-II; cd09208
703352008320	active site
703352008321	homopentamer interface [polypeptide binding]; other site
703352008322	dimer interface [polypeptide binding]; other site
703352008323	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
703352008324	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3453
703352008325	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
703352008326	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352008327	dimer interface [polypeptide binding]; other site
703352008328	conserved gate region; other site
703352008329	putative PBP binding loops; other site
703352008330	ABC-ATPase subunit interface; other site
703352008331	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352008332	dimer interface [polypeptide binding]; other site
703352008333	conserved gate region; other site
703352008334	putative PBP binding loops; other site
703352008335	ABC-ATPase subunit interface; other site
703352008336	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
703352008337	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
703352008338	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
703352008339	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
703352008340	Walker A/P-loop; other site
703352008341	ATP binding site [chemical binding]; other site
703352008342	Q-loop/lid; other site
703352008343	ABC transporter signature motif; other site
703352008344	Walker B; other site
703352008345	D-loop; other site
703352008346	H-loop/switch region; other site
703352008347	FAD dependent oxidoreductase; Region: DAO; pfam01266
703352008348	hydroxyglutarate oxidase; Provisional; Region: PRK11728
703352008349	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
703352008350	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
703352008351	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
703352008352	E-class dimer interface [polypeptide binding]; other site
703352008353	P-class dimer interface [polypeptide binding]; other site
703352008354	active site
703352008355	Cu2+ binding site [ion binding]; other site
703352008356	Zn2+ binding site [ion binding]; other site
703352008357	multicopper oxidase; Provisional; Region: PRK10965
703352008358	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
703352008359	Multicopper oxidase; Region: Cu-oxidase; pfam00394
703352008360	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
703352008361	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
703352008362	metabolite-proton symporter; Region: 2A0106; TIGR00883
703352008363	putative substrate translocation pore; other site
703352008364	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
703352008365	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
703352008366	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
703352008367	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
703352008368	dimer interface [polypeptide binding]; other site
703352008369	decamer (pentamer of dimers) interface [polypeptide binding]; other site
703352008370	catalytic triad [active]
703352008371	peroxidatic and resolving cysteines [active]
703352008372	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
703352008373	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
703352008374	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
703352008375	dimerization interface [polypeptide binding]; other site
703352008376	Protein of unknown function (DUF1612); Region: DUF1612; pfam07756
703352008377	HTH DNA binding domain; Region: HTH_13; pfam11972
703352008378	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
703352008379	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
703352008380	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
703352008381	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
703352008382	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
703352008383	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
703352008384	putative active site [active]
703352008385	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
703352008386	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
703352008387	substrate binding site [chemical binding]; other site
703352008388	ATP binding site [chemical binding]; other site
703352008389	Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863
703352008390	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892
703352008391	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
703352008392	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
703352008393	PYR/PP interface [polypeptide binding]; other site
703352008394	dimer interface [polypeptide binding]; other site
703352008395	TPP binding site [chemical binding]; other site
703352008396	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
703352008397	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
703352008398	TPP-binding site [chemical binding]; other site
703352008399	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
703352008400	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
703352008401	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
703352008402	Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643
703352008403	active site
703352008404	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
703352008405	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
703352008406	Walker A/P-loop; other site
703352008407	ATP binding site [chemical binding]; other site
703352008408	Q-loop/lid; other site
703352008409	ABC transporter signature motif; other site
703352008410	Walker B; other site
703352008411	D-loop; other site
703352008412	H-loop/switch region; other site
703352008413	TOBE domain; Region: TOBE_2; pfam08402
703352008414	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
703352008415	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352008416	dimer interface [polypeptide binding]; other site
703352008417	conserved gate region; other site
703352008418	putative PBP binding loops; other site
703352008419	ABC-ATPase subunit interface; other site
703352008420	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352008421	dimer interface [polypeptide binding]; other site
703352008422	conserved gate region; other site
703352008423	putative PBP binding loops; other site
703352008424	ABC-ATPase subunit interface; other site
703352008425	2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046
703352008426	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
703352008427	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905
703352008428	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
703352008429	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
703352008430	Glutamate binding site [chemical binding]; other site
703352008431	NAD binding site [chemical binding]; other site
703352008432	catalytic residues [active]
703352008433	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
703352008434	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
703352008435	putative DNA binding site [nucleotide binding]; other site
703352008436	putative Zn2+ binding site [ion binding]; other site
703352008437	AsnC family; Region: AsnC_trans_reg; pfam01037
703352008438	glycine dehydrogenase; Provisional; Region: PRK05367
703352008439	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
703352008440	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
703352008441	catalytic residue [active]
703352008442	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
703352008443	tetramer interface [polypeptide binding]; other site
703352008444	pyridoxal 5'-phosphate binding site [chemical binding]; other site
703352008445	catalytic residue [active]
703352008446	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
703352008447	lipoyl attachment site [posttranslational modification]; other site
703352008448	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
703352008449	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
703352008450	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
703352008451	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
703352008452	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
703352008453	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
703352008454	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
703352008455	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
703352008456	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
703352008457	putative active site [active]
703352008458	Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931
703352008459	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
703352008460	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
703352008461	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
703352008462	Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192
703352008463	putative active site [active]
703352008464	metal binding site [ion binding]; metal-binding site
703352008465	BA14K-like protein; Region: BA14K; pfam07886
703352008466	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
703352008467	EamA-like transporter family; Region: EamA; pfam00892
703352008468	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
703352008469	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
703352008470	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352008471	dimer interface [polypeptide binding]; other site
703352008472	conserved gate region; other site
703352008473	putative PBP binding loops; other site
703352008474	ABC-ATPase subunit interface; other site
703352008475	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
703352008476	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
703352008477	Walker A/P-loop; other site
703352008478	ATP binding site [chemical binding]; other site
703352008479	Q-loop/lid; other site
703352008480	ABC transporter signature motif; other site
703352008481	Walker B; other site
703352008482	D-loop; other site
703352008483	H-loop/switch region; other site
703352008484	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
703352008485	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
703352008486	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820
703352008487	dimer interface [polypeptide binding]; other site
703352008488	active site
703352008489	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
703352008490	substrate binding site [chemical binding]; other site
703352008491	catalytic residue [active]
703352008492	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
703352008493	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
703352008494	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
703352008495	putative active site [active]
703352008496	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
703352008497	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
703352008498	Walker A/P-loop; other site
703352008499	ATP binding site [chemical binding]; other site
703352008500	Q-loop/lid; other site
703352008501	ABC transporter signature motif; other site
703352008502	Walker B; other site
703352008503	D-loop; other site
703352008504	H-loop/switch region; other site
703352008505	TOBE domain; Region: TOBE; pfam03459
703352008506	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
703352008507	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
703352008508	NAD(P) binding site [chemical binding]; other site
703352008509	active site
703352008510	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
703352008511	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
703352008512	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352008513	dimer interface [polypeptide binding]; other site
703352008514	conserved gate region; other site
703352008515	putative PBP binding loops; other site
703352008516	ABC-ATPase subunit interface; other site
703352008517	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
703352008518	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352008519	dimer interface [polypeptide binding]; other site
703352008520	conserved gate region; other site
703352008521	putative PBP binding loops; other site
703352008522	ABC-ATPase subunit interface; other site
703352008523	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
703352008524	homotrimer interaction site [polypeptide binding]; other site
703352008525	putative active site [active]
703352008526	Uncharacterized conserved protein [Function unknown]; Region: COG5476
703352008527	Protein of unknown function (DUF1485); Region: DUF1485; pfam07364
703352008528	MlrC C-terminus; Region: MlrC_C; pfam07171
703352008529	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
703352008530	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
703352008531	Walker A/P-loop; other site
703352008532	ATP binding site [chemical binding]; other site
703352008533	Q-loop/lid; other site
703352008534	ABC transporter signature motif; other site
703352008535	Walker B; other site
703352008536	D-loop; other site
703352008537	H-loop/switch region; other site
703352008538	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
703352008539	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
703352008540	ABC-ATPase subunit  interface; other site
703352008541	dimer interface [polypeptide binding]; other site
703352008542	putative PBP binding regions; other site
703352008543	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
703352008544	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
703352008545	putative ligand binding residues [chemical binding]; other site
703352008546	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
703352008547	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
703352008548	HlyD family secretion protein; Region: HlyD_3; pfam13437
703352008549	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
703352008550	Fusaric acid resistance protein family; Region: FUSC; pfam04632
703352008551	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
703352008552	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
703352008553	MarR family; Region: MarR_2; pfam12802
703352008554	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
703352008555	RNA methyltransferase, RsmE family; Region: TIGR00046
703352008556	Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572
703352008557	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
703352008558	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
703352008559	generic binding surface II; other site
703352008560	generic binding surface I; other site
703352008561	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
703352008562	dimerization interface [polypeptide binding]; other site
703352008563	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
703352008564	Domain of unknown function (DUF1127); Region: DUF1127; pfam06568
703352008565	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
703352008566	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
703352008567	hypothetical protein; Reviewed; Region: PRK12275
703352008568	four helix bundle protein; Region: TIGR02436
703352008569	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
703352008570	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
703352008571	Hint domain; Region: Hint_2; pfam13403
703352008572	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
703352008573	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
703352008574	putative DNA binding site [nucleotide binding]; other site
703352008575	putative Zn2+ binding site [ion binding]; other site
703352008576	AsnC family; Region: AsnC_trans_reg; pfam01037
703352008577	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
703352008578	Predicted membrane protein [Function unknown]; Region: COG4541
703352008579	drug efflux system protein MdtG; Provisional; Region: PRK09874
703352008580	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
703352008581	putative substrate translocation pore; other site
703352008582	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345
703352008583	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
703352008584	putative NAD(P) binding site [chemical binding]; other site
703352008585	active site
703352008586	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
703352008587	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
703352008588	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
703352008589	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
703352008590	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
703352008591	putative active site [active]
703352008592	phosphogluconate dehydratase; Validated; Region: PRK09054
703352008593	6-phosphogluconate dehydratase; Region: edd; TIGR01196
703352008594	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
703352008595	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
703352008596	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
703352008597	homodimer interface [polypeptide binding]; other site
703352008598	NADP binding site [chemical binding]; other site
703352008599	substrate binding site [chemical binding]; other site
703352008600	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
703352008601	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
703352008602	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
703352008603	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
703352008604	Walker A/P-loop; other site
703352008605	ATP binding site [chemical binding]; other site
703352008606	Q-loop/lid; other site
703352008607	ABC transporter signature motif; other site
703352008608	Walker B; other site
703352008609	D-loop; other site
703352008610	H-loop/switch region; other site
703352008611	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
703352008612	potential frameshift: common BLAST hit: gi|376276562|ref|YP_005152623.1| peptide/nickel transport system ATP-binding protein
703352008613	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
703352008614	H-loop/switch region; other site
703352008615	potential frameshift: common BLAST hit: gi|376276562|ref|YP_005152623.1| peptide/nickel transport system ATP-binding protein
703352008616	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
703352008617	ABC transporter signature motif; other site
703352008618	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
703352008619	Walker A/P-loop; other site
703352008620	ATP binding site [chemical binding]; other site
703352008621	Q-loop/lid; other site
703352008622	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
703352008623	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352008624	dimer interface [polypeptide binding]; other site
703352008625	conserved gate region; other site
703352008626	putative PBP binding loops; other site
703352008627	ABC-ATPase subunit interface; other site
703352008628	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
703352008629	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352008630	dimer interface [polypeptide binding]; other site
703352008631	conserved gate region; other site
703352008632	putative PBP binding loops; other site
703352008633	ABC-ATPase subunit interface; other site
703352008634	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
703352008635	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517
703352008636	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
703352008637	active site clefts [active]
703352008638	zinc binding site [ion binding]; other site
703352008639	dimer interface [polypeptide binding]; other site
703352008640	tellurite resistance protein terB; Region: terB; cd07176
703352008641	putative metal binding site [ion binding]; other site
703352008642	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
703352008643	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
703352008644	active site
703352008645	nucleotide binding site [chemical binding]; other site
703352008646	HIGH motif; other site
703352008647	KMSKS motif; other site
703352008648	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
703352008649	Predicted transcriptional regulator [Transcription]; Region: COG2932
703352008650	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
703352008651	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
703352008652	Catalytic site [active]
703352008653	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
703352008654	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
703352008655	substrate binding site [chemical binding]; other site
703352008656	oxyanion hole (OAH) forming residues; other site
703352008657	trimer interface [polypeptide binding]; other site
703352008658	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
703352008659	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
703352008660	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
703352008661	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
703352008662	dimer interface [polypeptide binding]; other site
703352008663	active site
703352008664	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
703352008665	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
703352008666	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
703352008667	FAD binding site [chemical binding]; other site
703352008668	substrate binding site [chemical binding]; other site
703352008669	catalytic residues [active]
703352008670	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
703352008671	potential frameshift: common BLAST hit: gi|340792577|ref|YP_004758041.1| LysR family transcriptional regulator
703352008672	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
703352008673	putative dimerization interface [polypeptide binding]; other site
703352008674	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
703352008675	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
703352008676	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
703352008677	active site
703352008678	nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419
703352008679	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
703352008680	Walker A/P-loop; other site
703352008681	ATP binding site [chemical binding]; other site
703352008682	Q-loop/lid; other site
703352008683	ABC transporter signature motif; other site
703352008684	Walker B; other site
703352008685	D-loop; other site
703352008686	H-loop/switch region; other site
703352008687	nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418
703352008688	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
703352008689	Walker A/P-loop; other site
703352008690	ATP binding site [chemical binding]; other site
703352008691	Q-loop/lid; other site
703352008692	ABC transporter signature motif; other site
703352008693	Walker B; other site
703352008694	D-loop; other site
703352008695	H-loop/switch region; other site
703352008696	nickel transporter permease NikC; Provisional; Region: nikC; PRK10417
703352008697	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352008698	dimer interface [polypeptide binding]; other site
703352008699	conserved gate region; other site
703352008700	putative PBP binding loops; other site
703352008701	ABC-ATPase subunit interface; other site
703352008702	nickel transporter permease NikB; Provisional; Region: PRK10352
703352008703	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352008704	dimer interface [polypeptide binding]; other site
703352008705	conserved gate region; other site
703352008706	putative PBP binding loops; other site
703352008707	ABC-ATPase subunit interface; other site
703352008708	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
703352008709	The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489
703352008710	substrate binding site [chemical binding]; other site
703352008711	nickel responsive regulator; Provisional; Region: PRK02967
703352008712	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
703352008713	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
703352008714	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
703352008715	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
703352008716	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352008717	dimer interface [polypeptide binding]; other site
703352008718	conserved gate region; other site
703352008719	putative PBP binding loops; other site
703352008720	ABC-ATPase subunit interface; other site
703352008721	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352008722	putative PBP binding loops; other site
703352008723	ABC-ATPase subunit interface; other site
703352008724	ABC transporter; Region: ABC_tran; pfam00005
703352008725	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
703352008726	Q-loop/lid; other site
703352008727	ABC transporter signature motif; other site
703352008728	Walker B; other site
703352008729	D-loop; other site
703352008730	H-loop/switch region; other site
703352008731	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134
703352008732	hypothetical protein; Provisional; Region: PRK11622
703352008733	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
703352008734	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
703352008735	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
703352008736	Glucuronate isomerase; Region: UxaC; cl00829
703352008737	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
703352008738	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
703352008739	glucuronate isomerase; Reviewed; Region: PRK02925
703352008740	Transcriptional regulators [Transcription]; Region: GntR; COG1802
703352008741	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
703352008742	DNA-binding site [nucleotide binding]; DNA binding site
703352008743	FCD domain; Region: FCD; pfam07729
703352008744	mannonate dehydratase; Region: uxuA; TIGR00695
703352008745	mannonate dehydratase; Provisional; Region: PRK03906
703352008746	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
703352008747	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
703352008748	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
703352008749	HlyD family secretion protein; Region: HlyD_3; pfam13437
703352008750	camphor resistance protein CrcB; Provisional; Region: PRK14233
703352008751	camphor resistance protein CrcB; Provisional; Region: PRK14225
703352008752	PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993
703352008753	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
703352008754	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
703352008755	DNA binding residues [nucleotide binding]
703352008756	putative dimer interface [polypeptide binding]; other site
703352008757	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
703352008758	Sel1-like repeats; Region: SEL1; smart00671
703352008759	Sel1-like repeats; Region: SEL1; smart00671
703352008760	Sel1-like repeats; Region: SEL1; smart00671
703352008761	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
703352008762	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
703352008763	conserved hypothetical protein; Region: alph_Pro_TM; TIGR02186
703352008764	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
703352008765	putative active site [active]
703352008766	putative metal binding site [ion binding]; other site
703352008767	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
703352008768	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
703352008769	ATP binding site [chemical binding]; other site
703352008770	putative Mg++ binding site [ion binding]; other site
703352008771	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
703352008772	nucleotide binding region [chemical binding]; other site
703352008773	ATP-binding site [chemical binding]; other site
703352008774	DEAD/H associated; Region: DEAD_assoc; pfam08494
703352008775	ATP-dependent DNA ligase; Validated; Region: PRK09247
703352008776	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
703352008777	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
703352008778	FMN binding site [chemical binding]; other site
703352008779	substrate binding site [chemical binding]; other site
703352008780	putative catalytic residue [active]
703352008781	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
703352008782	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
703352008783	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
703352008784	HsdM N-terminal domain; Region: HsdM_N; pfam12161
703352008785	Methyltransferase domain; Region: Methyltransf_26; pfam13659
703352008786	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
703352008787	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
703352008788	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
703352008789	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
703352008790	ATP binding site [chemical binding]; other site
703352008791	putative Mg++ binding site [ion binding]; other site
703352008792	helicase superfamily c-terminal domain; Region: HELICc; smart00490
703352008793	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
703352008794	Protein of unknown function DUF45; Region: DUF45; pfam01863
703352008795	Protein of unknown function DUF91; Region: DUF91; cl00709
703352008796	Uncharacterized conserved protein [Function unknown]; Region: COG3586
703352008797	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
703352008798	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
703352008799	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
703352008800	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
703352008801	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
703352008802	inhibitor-cofactor binding pocket; inhibition site
703352008803	pyridoxal 5'-phosphate binding site [chemical binding]; other site
703352008804	catalytic residue [active]
703352008805	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
703352008806	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
703352008807	NAD(P) binding site [chemical binding]; other site
703352008808	active site
703352008809	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
703352008810	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
703352008811	FAD binding domain; Region: FAD_binding_4; pfam01565
703352008812	hypothetical protein; Validated; Region: PRK08238
703352008813	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
703352008814	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
703352008815	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
703352008816	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
703352008817	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
703352008818	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
703352008819	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
703352008820	ligand binding site [chemical binding]; other site
703352008821	dimerization interface [polypeptide binding]; other site
703352008822	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
703352008823	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
703352008824	TM-ABC transporter signature motif; other site
703352008825	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
703352008826	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
703352008827	Walker A/P-loop; other site
703352008828	ATP binding site [chemical binding]; other site
703352008829	Q-loop/lid; other site
703352008830	ABC transporter signature motif; other site
703352008831	Walker B; other site
703352008832	D-loop; other site
703352008833	H-loop/switch region; other site
703352008834	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
703352008835	Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; pfam10054
703352008836	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
703352008837	L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802
703352008838	putative N- and C-terminal domain interface [polypeptide binding]; other site
703352008839	putative active site [active]
703352008840	MgATP binding site [chemical binding]; other site
703352008841	catalytic site [active]
703352008842	metal binding site [ion binding]; metal-binding site
703352008843	putative xylulose binding site [chemical binding]; other site
703352008844	glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369
703352008845	hydroxyglutarate oxidase; Provisional; Region: PRK11728
703352008846	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
703352008847	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
703352008848	PCI domain; Region: PCI; cl02111
703352008849	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
703352008850	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
703352008851	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
703352008852	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
703352008853	triosephosphate isomerase; Provisional; Region: PRK14565
703352008854	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
703352008855	substrate binding site [chemical binding]; other site
703352008856	dimer interface [polypeptide binding]; other site
703352008857	catalytic triad [active]
703352008858	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
703352008859	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
703352008860	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
703352008861	intersubunit interface [polypeptide binding]; other site
703352008862	active site
703352008863	zinc binding site [ion binding]; other site
703352008864	Na+ binding site [ion binding]; other site
703352008865	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
703352008866	AMP binding site [chemical binding]; other site
703352008867	metal binding site [ion binding]; metal-binding site
703352008868	active site
703352008869	Uncharacterized conserved protein [Function unknown]; Region: COG1739
703352008870	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
703352008871	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
703352008872	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
703352008873	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
703352008874	G1 box; other site
703352008875	putative GEF interaction site [polypeptide binding]; other site
703352008876	GTP/Mg2+ binding site [chemical binding]; other site
703352008877	Switch I region; other site
703352008878	G2 box; other site
703352008879	G3 box; other site
703352008880	Switch II region; other site
703352008881	G4 box; other site
703352008882	G5 box; other site
703352008883	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
703352008884	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
703352008885	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
703352008886	MgtE intracellular N domain; Region: MgtE_N; pfam03448
703352008887	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
703352008888	Divalent cation transporter; Region: MgtE; pfam01769
703352008889	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
703352008890	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
703352008891	active site
703352008892	Zn binding site [ion binding]; other site
703352008893	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238
703352008894	dimer interface [polypeptide binding]; other site
703352008895	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
703352008896	Uncharacterized conserved small protein [Function unknown]; Region: COG5515
703352008897	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
703352008898	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
703352008899	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
703352008900	substrate binding site [chemical binding]; other site
703352008901	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
703352008902	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
703352008903	Transcriptional regulators [Transcription]; Region: MarR; COG1846
703352008904	MarR family; Region: MarR; pfam01047
703352008905	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
703352008906	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
703352008907	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
703352008908	putative substrate translocation pore; other site
703352008909	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
703352008910	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
703352008911	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
703352008912	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
703352008913	DNA binding site [nucleotide binding]
703352008914	active site
703352008915	tartrate dehydrogenase; Region: TTC; TIGR02089
703352008916	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
703352008917	Uncharacterized conserved protein [Function unknown]; Region: COG2835
703352008918	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
703352008919	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
703352008920	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
703352008921	catalytic residues [active]
703352008922	This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335
703352008923	putative deacylase active site [active]
703352008924	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
703352008925	apolar tunnel; other site
703352008926	heme binding site [chemical binding]; other site
703352008927	dimerization interface [polypeptide binding]; other site
703352008928	ornithine cyclodeaminase; Validated; Region: PRK07589
703352008929	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
703352008930	Arginase family; Region: Arginase; cd09989
703352008931	agmatinase; Region: agmatinase; TIGR01230
703352008932	active site
703352008933	Mn binding site [ion binding]; other site
703352008934	oligomer interface [polypeptide binding]; other site
703352008935	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
703352008936	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
703352008937	AsnC family; Region: AsnC_trans_reg; pfam01037
703352008938	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
703352008939	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
703352008940	FMN binding site [chemical binding]; other site
703352008941	active site
703352008942	substrate binding site [chemical binding]; other site
703352008943	catalytic residue [active]
703352008944	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
703352008945	dimerization interface [polypeptide binding]; other site
703352008946	putative DNA binding site [nucleotide binding]; other site
703352008947	putative Zn2+ binding site [ion binding]; other site
703352008948	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
703352008949	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
703352008950	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
703352008951	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
703352008952	RNA binding site [nucleotide binding]; other site
703352008953	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
703352008954	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
703352008955	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
703352008956	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
703352008957	putative Zn2+ binding site [ion binding]; other site
703352008958	putative DNA binding site [nucleotide binding]; other site
703352008959	dimerization interface [polypeptide binding]; other site
703352008960	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
703352008961	dimerization interface [polypeptide binding]; other site
703352008962	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
703352008963	aldehyde dehydrogenase family 7 member; Region: PLN02315
703352008964	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
703352008965	tetrameric interface [polypeptide binding]; other site
703352008966	NAD binding site [chemical binding]; other site
703352008967	catalytic residues [active]
703352008968	formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011
703352008969	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
703352008970	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
703352008971	putative active site [active]
703352008972	putative substrate binding site [chemical binding]; other site
703352008973	putative cosubstrate binding site; other site
703352008974	catalytic site [active]
703352008975	hypothetical protein; Provisional; Region: PRK02947
703352008976	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
703352008977	putative active site [active]
703352008978	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
703352008979	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
703352008980	active site
703352008981	dimer interface [polypeptide binding]; other site
703352008982	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
703352008983	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
703352008984	dimer interface [polypeptide binding]; other site
703352008985	active site
703352008986	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
703352008987	dimer interface [polypeptide binding]; other site
703352008988	active site
703352008989	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
703352008990	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
703352008991	DNA-binding site [nucleotide binding]; DNA binding site
703352008992	UTRA domain; Region: UTRA; pfam07702
703352008993	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
703352008994	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
703352008995	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
703352008996	HlyD family secretion protein; Region: HlyD_3; pfam13437
703352008997	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
703352008998	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
703352008999	HlyD family secretion protein; Region: HlyD_3; pfam13437
703352009000	putative membrane fusion protein; Region: TIGR02828
703352009001	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
703352009002	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
703352009003	putative molybdopterin cofactor binding site [chemical binding]; other site
703352009004	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
703352009005	putative molybdopterin cofactor binding site; other site
703352009006	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
703352009007	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
703352009008	phosphate binding site [ion binding]; other site
703352009009	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
703352009010	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
703352009011	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
703352009012	putative DNA binding site [nucleotide binding]; other site
703352009013	putative Zn2+ binding site [ion binding]; other site
703352009014	AsnC family; Region: AsnC_trans_reg; pfam01037
703352009015	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
703352009016	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
703352009017	active site
703352009018	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
703352009019	dimer interface [polypeptide binding]; other site
703352009020	substrate binding site [chemical binding]; other site
703352009021	catalytic residues [active]
703352009022	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
703352009023	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
703352009024	hydroxyglutarate oxidase; Provisional; Region: PRK11728
703352009025	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
703352009026	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
703352009027	non-specific DNA binding site [nucleotide binding]; other site
703352009028	salt bridge; other site
703352009029	sequence-specific DNA binding site [nucleotide binding]; other site
703352009030	Cupin domain; Region: Cupin_2; pfam07883
703352009031	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
703352009032	pyridoxal 5'-phosphate binding site [chemical binding]; other site
703352009033	catalytic residue [active]
703352009034	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
703352009035	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
703352009036	DNA-binding site [nucleotide binding]; DNA binding site
703352009037	UTRA domain; Region: UTRA; pfam07702
703352009038	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
703352009039	Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313
703352009040	active site
703352009041	imidazolonepropionase; Validated; Region: PRK09356
703352009042	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
703352009043	active site
703352009044	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
703352009045	active sites [active]
703352009046	potential frameshift: common BLAST hit: gi|340792702|ref|YP_004758166.1| histidine ammonia-lyase
703352009047	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
703352009048	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
703352009049	N-formylglutamate amidohydrolase; Region: hutG_amidohyd; TIGR02017
703352009050	urocanate hydratase; Provisional; Region: PRK05414
703352009051	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3758
703352009052	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
703352009053	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
703352009054	homodimer interface [polypeptide binding]; other site
703352009055	substrate-cofactor binding pocket; other site
703352009056	pyridoxal 5'-phosphate binding site [chemical binding]; other site
703352009057	catalytic residue [active]
703352009058	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
703352009059	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
703352009060	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
703352009061	TM-ABC transporter signature motif; other site
703352009062	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
703352009063	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
703352009064	Walker A/P-loop; other site
703352009065	ATP binding site [chemical binding]; other site
703352009066	Q-loop/lid; other site
703352009067	ABC transporter signature motif; other site
703352009068	Walker B; other site
703352009069	D-loop; other site
703352009070	H-loop/switch region; other site
703352009071	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
703352009072	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
703352009073	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
703352009074	putative ligand binding site [chemical binding]; other site
703352009075	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
703352009076	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
703352009077	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
703352009078	active site
703352009079	intersubunit interface [polypeptide binding]; other site
703352009080	catalytic residue [active]
703352009081	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
703352009082	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
703352009083	dihydroxy-acid dehydratase; Provisional; Region: PRK13017
703352009084	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
703352009085	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
703352009086	Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802
703352009087	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
703352009088	Transcriptional regulators [Transcription]; Region: FadR; COG2186
703352009089	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
703352009090	DNA-binding site [nucleotide binding]; DNA binding site
703352009091	FCD domain; Region: FCD; pfam07729
703352009092	thiamine pyrophosphate protein; Validated; Region: PRK08199
703352009093	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
703352009094	PYR/PP interface [polypeptide binding]; other site
703352009095	dimer interface [polypeptide binding]; other site
703352009096	TPP binding site [chemical binding]; other site
703352009097	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
703352009098	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
703352009099	TPP-binding site [chemical binding]; other site
703352009100	D-aminopeptidase; Reviewed; Region: PRK13128
703352009101	Beta-lactamase; Region: Beta-lactamase; pfam00144
703352009102	D-aminopeptidase, domain B; Region: DAP_B; pfam07930
703352009103	D-aminopeptidase, domain C; Region: DAP_C; pfam07932
703352009104	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
703352009105	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
703352009106	substrate binding pocket [chemical binding]; other site
703352009107	membrane-bound complex binding site; other site
703352009108	hinge residues; other site
703352009109	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
703352009110	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
703352009111	inhibitor-cofactor binding pocket; inhibition site
703352009112	pyridoxal 5'-phosphate binding site [chemical binding]; other site
703352009113	catalytic residue [active]
703352009114	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
703352009115	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
703352009116	active site
703352009117	substrate binding site [chemical binding]; other site
703352009118	ATP binding site [chemical binding]; other site
703352009119	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
703352009120	Peptidase family M23; Region: Peptidase_M23; pfam01551
703352009121	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
703352009122	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
703352009123	AsnC family; Region: AsnC_trans_reg; pfam01037
703352009124	Transcriptional regulator [Transcription]; Region: LysR; COG0583
703352009125	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
703352009126	LysR substrate binding domain; Region: LysR_substrate; pfam03466
703352009127	dimerization interface [polypeptide binding]; other site
703352009128	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
703352009129	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
703352009130	putative ligand binding site [chemical binding]; other site
703352009131	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
703352009132	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
703352009133	Walker A/P-loop; other site
703352009134	ATP binding site [chemical binding]; other site
703352009135	Q-loop/lid; other site
703352009136	ABC transporter signature motif; other site
703352009137	Walker B; other site
703352009138	D-loop; other site
703352009139	H-loop/switch region; other site
703352009140	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
703352009141	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
703352009142	Walker A/P-loop; other site
703352009143	ATP binding site [chemical binding]; other site
703352009144	Q-loop/lid; other site
703352009145	ABC transporter signature motif; other site
703352009146	Walker B; other site
703352009147	D-loop; other site
703352009148	H-loop/switch region; other site
703352009149	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
703352009150	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
703352009151	TM-ABC transporter signature motif; other site
703352009152	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
703352009153	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
703352009154	TM-ABC transporter signature motif; other site
703352009155	choline dehydrogenase; Validated; Region: PRK02106
703352009156	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
703352009157	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
703352009158	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
703352009159	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
703352009160	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
703352009161	Walker A/P-loop; other site
703352009162	ATP binding site [chemical binding]; other site
703352009163	Q-loop/lid; other site
703352009164	ABC transporter signature motif; other site
703352009165	Walker B; other site
703352009166	D-loop; other site
703352009167	H-loop/switch region; other site
703352009168	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
703352009169	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352009170	dimer interface [polypeptide binding]; other site
703352009171	conserved gate region; other site
703352009172	ABC-ATPase subunit interface; other site
703352009173	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
703352009174	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
703352009175	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
703352009176	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
703352009177	TPR motif; other site
703352009178	binding surface
703352009179	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
703352009180	binding surface
703352009181	TPR motif; other site
703352009182	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
703352009183	binding surface
703352009184	TPR motif; other site
703352009185	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
703352009186	Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990
703352009187	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
703352009188	putative active site [active]
703352009189	putative catalytic site [active]
703352009190	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
703352009191	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
703352009192	motif II; other site
703352009193	Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091
703352009194	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
703352009195	SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616
703352009196	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
703352009197	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
703352009198	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
703352009199	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
703352009200	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
703352009201	ligand binding site [chemical binding]; other site
703352009202	homodimer interface [polypeptide binding]; other site
703352009203	NAD(P) binding site [chemical binding]; other site
703352009204	trimer interface B [polypeptide binding]; other site
703352009205	trimer interface A [polypeptide binding]; other site
703352009206	Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835
703352009207	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
703352009208	Beta-lactamase; Region: Beta-lactamase; pfam00144
703352009209	PAS fold; Region: PAS_7; pfam12860
703352009210	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
703352009211	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
703352009212	metal binding site [ion binding]; metal-binding site
703352009213	active site
703352009214	I-site; other site
703352009215	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
703352009216	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
703352009217	classical (c) SDRs; Region: SDR_c; cd05233
703352009218	NAD(P) binding site [chemical binding]; other site
703352009219	active site
703352009220	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
703352009221	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
703352009222	putative ligand binding site [chemical binding]; other site
703352009223	NAD binding site [chemical binding]; other site
703352009224	catalytic site [active]
703352009225	Transcriptional regulators [Transcription]; Region: PurR; COG1609
703352009226	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
703352009227	DNA binding site [nucleotide binding]
703352009228	domain linker motif; other site
703352009229	Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289
703352009230	putative dimerization interface [polypeptide binding]; other site
703352009231	putative ligand binding site [chemical binding]; other site
703352009232	transcriptional regulator SlyA; Provisional; Region: PRK03573
703352009233	MarR family; Region: MarR_2; cl17246
703352009234	Creatinine amidohydrolase; Region: Creatininase; pfam02633
703352009235	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
703352009236	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
703352009237	P-loop, Walker A motif; other site
703352009238	Base recognition motif; other site
703352009239	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
703352009240	FOG: WD40 repeat [General function prediction only]; Region: COG2319
703352009241	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
703352009242	structural tetrad; other site
703352009243	Predicted esterase [General function prediction only]; Region: COG0400
703352009244	putative hydrolase; Provisional; Region: PRK11460
703352009245	TMAO/DMSO reductase; Reviewed; Region: PRK05363
703352009246	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
703352009247	Moco binding site; other site
703352009248	metal coordination site [ion binding]; other site
703352009249	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
703352009250	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
703352009251	homotrimer interaction site [polypeptide binding]; other site
703352009252	putative active site [active]
703352009253	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
703352009254	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
703352009255	TM-ABC transporter signature motif; other site
703352009256	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
703352009257	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
703352009258	TM-ABC transporter signature motif; other site
703352009259	potential frameshift: common BLAST hit: gi|376277495|ref|YP_005153556.1| simple sugar transport system ATP-binding protein
703352009260	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
703352009261	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
703352009262	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
703352009263	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
703352009264	Walker A/P-loop; other site
703352009265	ATP binding site [chemical binding]; other site
703352009266	Q-loop/lid; other site
703352009267	ABC transporter signature motif; other site
703352009268	Walker B; other site
703352009269	D-loop; other site
703352009270	H-loop/switch region; other site
703352009271	Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300
703352009272	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
703352009273	putative ligand binding site [chemical binding]; other site
703352009274	Transcriptional regulator [Transcription]; Region: IclR; COG1414
703352009275	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
703352009276	Bacterial transcriptional regulator; Region: IclR; pfam01614
703352009277	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
703352009278	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
703352009279	N-terminal plug; other site
703352009280	ligand-binding site [chemical binding]; other site
703352009281	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
703352009282	dimer interface [polypeptide binding]; other site
703352009283	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
703352009284	metal binding site [ion binding]; metal-binding site
703352009285	glutathionine S-transferase; Provisional; Region: PRK10542
703352009286	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
703352009287	C-terminal domain interface [polypeptide binding]; other site
703352009288	GSH binding site (G-site) [chemical binding]; other site
703352009289	dimer interface [polypeptide binding]; other site
703352009290	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
703352009291	dimer interface [polypeptide binding]; other site
703352009292	N-terminal domain interface [polypeptide binding]; other site
703352009293	substrate binding pocket (H-site) [chemical binding]; other site
703352009294	Protein of unknown function (DUF2778); Region: DUF2778; pfam10908
703352009295	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
703352009296	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
703352009297	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
703352009298	metal binding site [ion binding]; metal-binding site
703352009299	active site
703352009300	I-site; other site
703352009301	Predicted dehydrogenase [General function prediction only]; Region: COG0579
703352009302	hydroxyglutarate oxidase; Provisional; Region: PRK11728
703352009303	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
703352009304	DNA polymerase III subunit epsilon; Validated; Region: PRK09182
703352009305	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
703352009306	active site
703352009307	catalytic site [active]
703352009308	substrate binding site [chemical binding]; other site
703352009309	amidase; Provisional; Region: PRK07042
703352009310	Amidase; Region: Amidase; cl11426
703352009311	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
703352009312	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
703352009313	Walker A/P-loop; other site
703352009314	ATP binding site [chemical binding]; other site
703352009315	Q-loop/lid; other site
703352009316	ABC transporter signature motif; other site
703352009317	Walker B; other site
703352009318	D-loop; other site
703352009319	H-loop/switch region; other site
703352009320	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
703352009321	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
703352009322	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
703352009323	Walker A/P-loop; other site
703352009324	ATP binding site [chemical binding]; other site
703352009325	Q-loop/lid; other site
703352009326	ABC transporter signature motif; other site
703352009327	Walker B; other site
703352009328	D-loop; other site
703352009329	H-loop/switch region; other site
703352009330	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
703352009331	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
703352009332	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352009333	dimer interface [polypeptide binding]; other site
703352009334	conserved gate region; other site
703352009335	putative PBP binding loops; other site
703352009336	ABC-ATPase subunit interface; other site
703352009337	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
703352009338	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352009339	dimer interface [polypeptide binding]; other site
703352009340	conserved gate region; other site
703352009341	putative PBP binding loops; other site
703352009342	ABC-ATPase subunit interface; other site
703352009343	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
703352009344	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494
703352009345	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345
703352009346	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
703352009347	putative NAD(P) binding site [chemical binding]; other site
703352009348	active site
703352009349	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
703352009350	Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109
703352009351	NAD(P) binding site [chemical binding]; other site
703352009352	catalytic residues [active]
703352009353	catalytic residues [active]
703352009354	Transcriptional regulators [Transcription]; Region: GntR; COG1802
703352009355	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
703352009356	DNA-binding site [nucleotide binding]; DNA binding site
703352009357	FCD domain; Region: FCD; pfam07729
703352009358	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
703352009359	Major Facilitator Superfamily; Region: MFS_1; pfam07690
703352009360	putative substrate translocation pore; other site
703352009361	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
703352009362	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
703352009363	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
703352009364	homotrimer interaction site [polypeptide binding]; other site
703352009365	putative active site [active]
703352009366	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
703352009367	ribonuclease P; Reviewed; Region: rnpA; PRK01313
703352009368	membrane protein insertase; Provisional; Region: PRK01318
703352009369	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
703352009370	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
703352009371	G1 box; other site
703352009372	GTP/Mg2+ binding site [chemical binding]; other site
703352009373	Switch I region; other site
703352009374	G2 box; other site
703352009375	G3 box; other site
703352009376	Switch II region; other site
703352009377	G4 box; other site
703352009378	G5 box; other site
703352009379	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
703352009380	homohexameric interface [polypeptide binding]; other site
703352009381	feedback inhibition sensing region; other site
703352009382	nucleotide binding site [chemical binding]; other site
703352009383	N-acetyl-L-glutamate binding site [chemical binding]; other site
703352009384	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
703352009385	?-D-glucose-1-phosphatase; Provisional; Region: PRK09456
703352009386	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
703352009387	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
703352009388	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
703352009389	trimer interface [polypeptide binding]; other site
703352009390	active site
703352009391	substrate binding site [chemical binding]; other site
703352009392	CoA binding site [chemical binding]; other site
703352009393	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035
703352009394	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
703352009395	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
703352009396	metal binding site [ion binding]; metal-binding site
703352009397	dimer interface [polypeptide binding]; other site
703352009398	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
703352009399	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
703352009400	dimerization interface 3.5A [polypeptide binding]; other site
703352009401	active site
703352009402	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
703352009403	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
703352009404	putative active site [active]
703352009405	substrate binding site [chemical binding]; other site
703352009406	putative cosubstrate binding site; other site
703352009407	catalytic site [active]
703352009408	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
703352009409	substrate binding site [chemical binding]; other site
703352009410	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
703352009411	active site
703352009412	catalytic residues [active]
703352009413	metal binding site [ion binding]; metal-binding site
703352009414	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
703352009415	RmuC family; Region: RmuC; pfam02646
703352009416	Rdx family; Region: Rdx; cl01407
703352009417	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
703352009418	catalytic site [active]
703352009419	metal binding site [ion binding]; metal-binding site
703352009420	GTP-binding protein LepA; Provisional; Region: PRK05433
703352009421	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
703352009422	G1 box; other site
703352009423	putative GEF interaction site [polypeptide binding]; other site
703352009424	GTP/Mg2+ binding site [chemical binding]; other site
703352009425	Switch I region; other site
703352009426	G2 box; other site
703352009427	G3 box; other site
703352009428	Switch II region; other site
703352009429	G4 box; other site
703352009430	G5 box; other site
703352009431	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
703352009432	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
703352009433	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
703352009434	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
703352009435	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
703352009436	putative NAD(P) binding site [chemical binding]; other site
703352009437	active site
703352009438	Undecaprenyl pyrophosphate phosphatase [Lipid transport and metabolism]; Region: BacA; COG1968
703352009439	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
703352009440	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
703352009441	C-terminal domain interface [polypeptide binding]; other site
703352009442	GSH binding site (G-site) [chemical binding]; other site
703352009443	dimer interface [polypeptide binding]; other site
703352009444	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
703352009445	N-terminal domain interface [polypeptide binding]; other site
703352009446	dimer interface [polypeptide binding]; other site
703352009447	substrate binding pocket (H-site) [chemical binding]; other site
703352009448	epoxyqueuosine reductase; Region: TIGR00276
703352009449	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
703352009450	HEAT repeat; Region: HEAT; pfam02985
703352009451	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
703352009452	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
703352009453	putative NAD(P) binding site [chemical binding]; other site
703352009454	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
703352009455	Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770
703352009456	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
703352009457	active site
703352009458	dimer interfaces [polypeptide binding]; other site
703352009459	catalytic residues [active]
703352009460	Glucokinase [Carbohydrate transport and metabolism]; Region: Glk; COG0837
703352009461	glucokinase, proteobacterial type; Region: glk; TIGR00749
703352009462	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
703352009463	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
703352009464	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
703352009465	Walker A/P-loop; other site
703352009466	ATP binding site [chemical binding]; other site
703352009467	Q-loop/lid; other site
703352009468	ABC transporter signature motif; other site
703352009469	Walker B; other site
703352009470	D-loop; other site
703352009471	H-loop/switch region; other site
703352009472	Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289
703352009473	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
703352009474	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
703352009475	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
703352009476	catalytic core [active]
703352009477	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
703352009478	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
703352009479	active site
703352009480	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
703352009481	putative FMN binding site [chemical binding]; other site
703352009482	Predicted membrane protein [Function unknown]; Region: COG3714
703352009483	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
703352009484	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
703352009485	NAD(P) binding site [chemical binding]; other site
703352009486	catalytic residues [active]
703352009487	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
703352009488	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
703352009489	putative catalytic site [active]
703352009490	putative metal binding site [ion binding]; other site
703352009491	putative phosphate binding site [ion binding]; other site
703352009492	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
703352009493	Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157
703352009494	putative active site [active]
703352009495	catalytic site [active]
703352009496	Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163
703352009497	putative active site [active]
703352009498	catalytic site [active]
703352009499	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
703352009500	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
703352009501	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
703352009502	G1 box; other site
703352009503	putative GEF interaction site [polypeptide binding]; other site
703352009504	GTP/Mg2+ binding site [chemical binding]; other site
703352009505	Switch I region; other site
703352009506	G2 box; other site
703352009507	G3 box; other site
703352009508	Switch II region; other site
703352009509	G4 box; other site
703352009510	G5 box; other site
703352009511	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
703352009512	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
703352009513	Flavoprotein; Region: Flavoprotein; pfam02441
703352009514	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
703352009515	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
703352009516	ABC1 family; Region: ABC1; pfam03109
703352009517	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
703352009518	active site
703352009519	ATP binding site [chemical binding]; other site
703352009520	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
703352009521	substrate binding site [chemical binding]; other site
703352009522	activation loop (A-loop); other site
703352009523	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
703352009524	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
703352009525	S-adenosylmethionine binding site [chemical binding]; other site
703352009526	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
703352009527	active site
703352009528	hypothetical protein; Provisional; Region: PRK00736
703352009529	methionine sulfoxide reductase A; Provisional; Region: PRK00058
703352009530	putative transposase OrfB; Reviewed; Region: PHA02517
703352009531	HTH-like domain; Region: HTH_21; pfam13276
703352009532	Integrase core domain; Region: rve; pfam00665
703352009533	Integrase core domain; Region: rve_3; pfam13683
703352009534	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
703352009535	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
703352009536	Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235
703352009537	intersubunit interface [polypeptide binding]; other site
703352009538	active site
703352009539	Zn2+ binding site [ion binding]; other site
703352009540	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
703352009541	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
703352009542	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
703352009543	catalytic residue [active]
703352009544	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
703352009545	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
703352009546	Walker A/P-loop; other site
703352009547	ATP binding site [chemical binding]; other site
703352009548	Q-loop/lid; other site
703352009549	ABC transporter signature motif; other site
703352009550	Walker B; other site
703352009551	D-loop; other site
703352009552	H-loop/switch region; other site
703352009553	TOBE domain; Region: TOBE_2; pfam08402
703352009554	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352009555	dimer interface [polypeptide binding]; other site
703352009556	conserved gate region; other site
703352009557	putative PBP binding loops; other site
703352009558	ABC-ATPase subunit interface; other site
703352009559	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
703352009560	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352009561	dimer interface [polypeptide binding]; other site
703352009562	conserved gate region; other site
703352009563	putative PBP binding loops; other site
703352009564	ABC-ATPase subunit interface; other site
703352009565	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
703352009566	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
703352009567	amidase; Provisional; Region: PRK07486
703352009568	Amidase; Region: Amidase; cl11426
703352009569	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
703352009570	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
703352009571	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
703352009572	Walker A/P-loop; other site
703352009573	ATP binding site [chemical binding]; other site
703352009574	Q-loop/lid; other site
703352009575	ABC transporter signature motif; other site
703352009576	Walker B; other site
703352009577	D-loop; other site
703352009578	H-loop/switch region; other site
703352009579	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
703352009580	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
703352009581	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
703352009582	Walker A/P-loop; other site
703352009583	ATP binding site [chemical binding]; other site
703352009584	Q-loop/lid; other site
703352009585	ABC transporter signature motif; other site
703352009586	Walker B; other site
703352009587	D-loop; other site
703352009588	H-loop/switch region; other site
703352009589	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
703352009590	potential frameshift: common BLAST hit: gi|376279041|ref|YP_005109074.1| peptide ABC transporter, permease protein, putative
703352009591	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
703352009592	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
703352009593	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352009594	dimer interface [polypeptide binding]; other site
703352009595	ABC-ATPase subunit interface; other site
703352009596	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
703352009597	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352009598	dimer interface [polypeptide binding]; other site
703352009599	conserved gate region; other site
703352009600	putative PBP binding loops; other site
703352009601	ABC-ATPase subunit interface; other site
703352009602	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
703352009603	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
703352009604	Transcriptional regulators [Transcription]; Region: GntR; COG1802
703352009605	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
703352009606	DNA-binding site [nucleotide binding]; DNA binding site
703352009607	FCD domain; Region: FCD; pfam07729
703352009608	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
703352009609	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
703352009610	Walker A/P-loop; other site
703352009611	ATP binding site [chemical binding]; other site
703352009612	Q-loop/lid; other site
703352009613	ABC transporter signature motif; other site
703352009614	Walker B; other site
703352009615	D-loop; other site
703352009616	H-loop/switch region; other site
703352009617	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
703352009618	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
703352009619	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
703352009620	Walker A/P-loop; other site
703352009621	ATP binding site [chemical binding]; other site
703352009622	Q-loop/lid; other site
703352009623	ABC transporter signature motif; other site
703352009624	Walker B; other site
703352009625	D-loop; other site
703352009626	H-loop/switch region; other site
703352009627	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
703352009628	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
703352009629	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352009630	dimer interface [polypeptide binding]; other site
703352009631	conserved gate region; other site
703352009632	putative PBP binding loops; other site
703352009633	ABC-ATPase subunit interface; other site
703352009634	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
703352009635	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352009636	dimer interface [polypeptide binding]; other site
703352009637	conserved gate region; other site
703352009638	putative PBP binding loops; other site
703352009639	ABC-ATPase subunit interface; other site
703352009640	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
703352009641	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502
703352009642	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
703352009643	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
703352009644	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
703352009645	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
703352009646	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
703352009647	active site
703352009648	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
703352009649	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
703352009650	active site
703352009651	enoyl-CoA hydratase; Provisional; Region: PRK08138
703352009652	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
703352009653	substrate binding site [chemical binding]; other site
703352009654	oxyanion hole (OAH) forming residues; other site
703352009655	trimer interface [polypeptide binding]; other site
703352009656	3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268
703352009657	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
703352009658	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
703352009659	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
703352009660	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
703352009661	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
703352009662	tetramer interface [polypeptide binding]; other site
703352009663	TPP-binding site [chemical binding]; other site
703352009664	heterodimer interface [polypeptide binding]; other site
703352009665	phosphorylation loop region [posttranslational modification]
703352009666	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
703352009667	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
703352009668	alpha subunit interface [polypeptide binding]; other site
703352009669	TPP binding site [chemical binding]; other site
703352009670	heterodimer interface [polypeptide binding]; other site
703352009671	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
703352009672	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
703352009673	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
703352009674	acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875
703352009675	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
703352009676	E3 interaction surface; other site
703352009677	lipoyl attachment site [posttranslational modification]; other site
703352009678	e3 binding domain; Region: E3_binding; pfam02817
703352009679	Serine hydrolase; Region: Ser_hydrolase; cl17834
703352009680	Transcriptional regulator [Transcription]; Region: IclR; COG1414
703352009681	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
703352009682	Bacterial transcriptional regulator; Region: IclR; pfam01614
703352009683	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
703352009684	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352009685	dimer interface [polypeptide binding]; other site
703352009686	conserved gate region; other site
703352009687	putative PBP binding loops; other site
703352009688	ABC-ATPase subunit interface; other site
703352009689	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
703352009690	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
703352009691	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
703352009692	ABC transporter; Region: ABC_tran; pfam00005
703352009693	Q-loop/lid; other site
703352009694	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
703352009695	ABC transporter signature motif; other site
703352009696	Walker B; other site
703352009697	D-loop; other site
703352009698	H-loop/switch region; other site
703352009699	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
703352009700	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
703352009701	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
703352009702	Walker A/P-loop; other site
703352009703	ATP binding site [chemical binding]; other site
703352009704	Q-loop/lid; other site
703352009705	ABC transporter signature motif; other site
703352009706	Walker B; other site
703352009707	D-loop; other site
703352009708	H-loop/switch region; other site
703352009709	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
703352009710	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
703352009711	CoA-transferase family III; Region: CoA_transf_3; pfam02515
703352009712	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
703352009713	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
703352009714	tetramerization interface [polypeptide binding]; other site
703352009715	NAD(P) binding site [chemical binding]; other site
703352009716	catalytic residues [active]
703352009717	Transcriptional regulators [Transcription]; Region: GntR; COG1802
703352009718	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
703352009719	DNA-binding site [nucleotide binding]; DNA binding site
703352009720	FCD domain; Region: FCD; pfam07729
703352009721	putative transposase OrfB; Reviewed; Region: PHA02517
703352009722	HTH-like domain; Region: HTH_21; pfam13276
703352009723	Integrase core domain; Region: rve; pfam00665
703352009724	Integrase core domain; Region: rve_3; pfam13683
703352009725	Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971
703352009726	Rrf2 family protein; Region: rrf2_super; TIGR00738
703352009727	Transcriptional regulator; Region: Rrf2; pfam02082
703352009728	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
703352009729	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
703352009730	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
703352009731	ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531
703352009732	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
703352009733	metal binding site [ion binding]; metal-binding site
703352009734	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
703352009735	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
703352009736	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
703352009737	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
703352009738	ABC-ATPase subunit  interface; other site
703352009739	dimer interface [polypeptide binding]; other site
703352009740	putative PBP binding regions; other site
703352009741	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
703352009742	metal binding site 2 [ion binding]; metal-binding site
703352009743	putative DNA binding helix; other site
703352009744	metal binding site 1 [ion binding]; metal-binding site
703352009745	dimer interface [polypeptide binding]; other site
703352009746	structural Zn2+ binding site [ion binding]; other site
703352009747	FlgN protein; Region: FlgN; pfam05130
703352009748	Rod binding protein; Region: Rod-binding; pfam10135
703352009749	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
703352009750	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980
703352009751	FHIPEP family; Region: FHIPEP; pfam00771
703352009752	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980
703352009753	flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010
703352009754	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009
703352009755	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
703352009756	Flagellar biosynthesis regulator FlbT [Cell motility and secretion]; Region: FlbT; COG5443
703352009757	Flagellar biosynthesis regulator FlaF [Cell motility and secretion]; Region: FlaF; COG5442
703352009758	flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793
703352009759	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008
703352009760	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
703352009761	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
703352009762	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521
703352009763	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
703352009764	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
703352009765	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
703352009766	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
703352009767	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
703352009768	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
703352009769	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
703352009770	DNA binding site [nucleotide binding]
703352009771	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
703352009772	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
703352009773	N-acetyl-D-glucosamine binding site [chemical binding]; other site
703352009774	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
703352009775	chemotaxis protein; Reviewed; Region: PRK12798
703352009776	flagellar motor protein MotB; Validated; Region: motB; PRK05996
703352009777	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
703352009778	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
703352009779	ligand binding site [chemical binding]; other site
703352009780	Flagellar basal body M-ring protein [Cell motility and secretion]; Region: fliF; COG1766
703352009781	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
703352009782	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
703352009783	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
703352009784	flagellin; Reviewed; Region: PRK12687
703352009785	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
703352009786	potential frameshift: common BLAST hit: gi|376270493|ref|YP_005113538.1| Type V secretory pathway, adhesin AidA
703352009787	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
703352009788	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
703352009789	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
703352009790	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373
703352009791	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
703352009792	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
703352009793	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
703352009794	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
703352009795	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
703352009796	Autotransporter beta-domain; Region: Autotransporter; smart00869
703352009797	Uncharacterized conserved protein [Function unknown]; Region: COG3268
703352009798	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
703352009799	D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634
703352009800	putative ligand binding site [chemical binding]; other site
703352009801	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
703352009802	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
703352009803	Walker A/P-loop; other site
703352009804	ATP binding site [chemical binding]; other site
703352009805	Q-loop/lid; other site
703352009806	ABC transporter signature motif; other site
703352009807	Walker B; other site
703352009808	D-loop; other site
703352009809	H-loop/switch region; other site
703352009810	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
703352009811	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
703352009812	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
703352009813	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
703352009814	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
703352009815	TM-ABC transporter signature motif; other site
703352009816	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
703352009817	HTH domain; Region: HTH_11; cl17392
703352009818	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
703352009819	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
703352009820	Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106
703352009821	NAD(P) binding site [chemical binding]; other site
703352009822	catalytic residues [active]
703352009823	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
703352009824	choline dehydrogenase; Validated; Region: PRK02106
703352009825	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Region: HpaI; TIGR02311
703352009826	2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312
703352009827	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
703352009828	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
703352009829	3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295
703352009830	N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266
703352009831	tetramer interface [polypeptide binding]; other site
703352009832	C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256
703352009833	tetramer interface [polypeptide binding]; other site
703352009834	active site
703352009835	metal binding site [ion binding]; metal-binding site
703352009836	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299
703352009837	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
703352009838	NAD binding site [chemical binding]; other site
703352009839	catalytic residues [active]
703352009840	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
703352009841	putative substrate binding pocket [chemical binding]; other site
703352009842	trimer interface [polypeptide binding]; other site
703352009843	homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337
703352009844	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
703352009845	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
703352009846	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
703352009847	active site
703352009848	ATP binding site [chemical binding]; other site
703352009849	substrate binding site [chemical binding]; other site
703352009850	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
703352009851	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
703352009852	inhibitor-cofactor binding pocket; inhibition site
703352009853	pyridoxal 5'-phosphate binding site [chemical binding]; other site
703352009854	catalytic residue [active]
703352009855	hypothetical protein; Provisional; Region: PRK07481
703352009856	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
703352009857	inhibitor-cofactor binding pocket; inhibition site
703352009858	pyridoxal 5'-phosphate binding site [chemical binding]; other site
703352009859	catalytic residue [active]
703352009860	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
703352009861	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
703352009862	motif II; other site
703352009863	Uncharacterized conserved protein [Function unknown]; Region: COG5441; cl02262
703352009864	Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792
703352009865	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
703352009866	Transcriptional regulator [Transcription]; Region: IclR; COG1414
703352009867	Bacterial transcriptional regulator; Region: IclR; pfam01614
703352009868	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
703352009869	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
703352009870	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
703352009871	NAD(P) binding site [chemical binding]; other site
703352009872	catalytic residues [active]
703352009873	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
703352009874	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
703352009875	active site
703352009876	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
703352009877	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
703352009878	putative ligand binding site [chemical binding]; other site
703352009879	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
703352009880	TM-ABC transporter signature motif; other site
703352009881	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
703352009882	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
703352009883	TM-ABC transporter signature motif; other site
703352009884	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
703352009885	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
703352009886	Walker A/P-loop; other site
703352009887	ATP binding site [chemical binding]; other site
703352009888	Q-loop/lid; other site
703352009889	ABC transporter signature motif; other site
703352009890	Walker B; other site
703352009891	D-loop; other site
703352009892	H-loop/switch region; other site
703352009893	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
703352009894	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
703352009895	Walker A/P-loop; other site
703352009896	ATP binding site [chemical binding]; other site
703352009897	Q-loop/lid; other site
703352009898	ABC transporter signature motif; other site
703352009899	Walker B; other site
703352009900	D-loop; other site
703352009901	H-loop/switch region; other site
703352009902	Protein of unknown function (DUF1634); Region: DUF1634; pfam07843
703352009903	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
703352009904	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
703352009905	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
703352009906	DNA-binding site [nucleotide binding]; DNA binding site
703352009907	UTRA domain; Region: UTRA; pfam07702
703352009908	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
703352009909	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
703352009910	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
703352009911	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352009912	dimer interface [polypeptide binding]; other site
703352009913	conserved gate region; other site
703352009914	putative PBP binding loops; other site
703352009915	ABC-ATPase subunit interface; other site
703352009916	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352009917	dimer interface [polypeptide binding]; other site
703352009918	conserved gate region; other site
703352009919	putative PBP binding loops; other site
703352009920	ABC-ATPase subunit interface; other site
703352009921	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
703352009922	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
703352009923	Walker A/P-loop; other site
703352009924	ATP binding site [chemical binding]; other site
703352009925	Q-loop/lid; other site
703352009926	ABC transporter signature motif; other site
703352009927	Walker B; other site
703352009928	D-loop; other site
703352009929	H-loop/switch region; other site
703352009930	TOBE domain; Region: TOBE_2; pfam08402
703352009931	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
703352009932	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
703352009933	active site
703352009934	metal binding site [ion binding]; metal-binding site
703352009935	potential frameshift: common BLAST hit: gi|225686926|ref|YP_002734898.1| arylsulfatase D
703352009936	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
703352009937	Sulfatase; Region: Sulfatase; cl17466
703352009938	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
703352009939	Sulfatase; Region: Sulfatase; cl17466
703352009940	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
703352009941	NMT1-like family; Region: NMT1_2; pfam13379
703352009942	substrate binding pocket [chemical binding]; other site
703352009943	membrane-bound complex binding site; other site
703352009944	hinge residues; other site
703352009945	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
703352009946	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
703352009947	Walker A/P-loop; other site
703352009948	ATP binding site [chemical binding]; other site
703352009949	Q-loop/lid; other site
703352009950	ABC transporter signature motif; other site
703352009951	Walker B; other site
703352009952	D-loop; other site
703352009953	H-loop/switch region; other site
703352009954	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
703352009955	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
703352009956	dimer interface [polypeptide binding]; other site
703352009957	conserved gate region; other site
703352009958	putative PBP binding loops; other site
703352009959	ABC-ATPase subunit interface; other site
703352009960	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
703352009961	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
703352009962	nucleotide binding site [chemical binding]; other site
703352009963	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
703352009964	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
703352009965	N-terminal plug; other site
703352009966	ligand-binding site [chemical binding]; other site
703352009967	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
703352009968	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
703352009969	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
703352009970	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_5; cd06338
703352009971	putative ligand binding site [chemical binding]; other site
703352009972	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
703352009973	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
703352009974	TM-ABC transporter signature motif; other site
703352009975	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
703352009976	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
703352009977	TM-ABC transporter signature motif; other site
703352009978	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
703352009979	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
703352009980	Walker A/P-loop; other site
703352009981	ATP binding site [chemical binding]; other site
703352009982	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
703352009983	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
703352009984	ABC transporter signature motif; other site
703352009985	Walker B; other site
703352009986	D-loop; other site
703352009987	H-loop/switch region; other site
703352009988	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
703352009989	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
703352009990	Walker A/P-loop; other site
703352009991	ATP binding site [chemical binding]; other site
703352009992	Q-loop/lid; other site
703352009993	ABC transporter signature motif; other site
703352009994	Walker B; other site
703352009995	D-loop; other site
703352009996	H-loop/switch region; other site
703352009997	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
703352009998	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
703352009999	Soluble P-type ATPase [General function prediction only]; Region: COG4087
703352010000	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
703352010001	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
703352010002	FeS/SAM binding site; other site
703352010003	HemN C-terminal domain; Region: HemN_C; pfam06969
703352010004	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
703352010005	MerR family regulatory protein; Region: MerR; pfam00376
703352010006	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
703352010007	P-loop; other site
703352010008	Magnesium ion binding site [ion binding]; other site
703352010009	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
703352010010	P-loop; other site
703352010011	Magnesium ion binding site [ion binding]; other site
703352010012	plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454
703352010013	ParB-like nuclease domain; Region: ParB; smart00470