-- dump date   	20140619_010959
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
359391000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
359391000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
359391000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944
359391000004	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
359391000005	DnaA box-binding interface [nucleotide binding]; other site
359391000006	DNA polymerase III subunit beta; Validated; Region: PRK05643
359391000007	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
359391000008	putative DNA binding surface [nucleotide binding]; other site
359391000009	dimer interface [polypeptide binding]; other site
359391000010	beta-clamp/clamp loader binding surface; other site
359391000011	beta-clamp/translesion DNA polymerase binding surface; other site
359391000012	recombination protein F; Reviewed; Region: recF; PRK00064
359391000013	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
359391000014	Walker A/P-loop; other site
359391000015	ATP binding site [chemical binding]; other site
359391000016	Q-loop/lid; other site
359391000017	ABC transporter signature motif; other site
359391000018	Walker B; other site
359391000019	D-loop; other site
359391000020	H-loop/switch region; other site
359391000021	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
359391000022	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
359391000023	ATP binding site [chemical binding]; other site
359391000024	substrate interface [chemical binding]; other site
359391000025	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
359391000026	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
359391000027	putative ligand binding site [chemical binding]; other site
359391000028	NAD binding site [chemical binding]; other site
359391000029	dimerization interface [polypeptide binding]; other site
359391000030	catalytic site [active]
359391000031	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
359391000032	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
359391000033	Walker A/P-loop; other site
359391000034	ATP binding site [chemical binding]; other site
359391000035	Q-loop/lid; other site
359391000036	ABC transporter signature motif; other site
359391000037	Walker B; other site
359391000038	D-loop; other site
359391000039	H-loop/switch region; other site
359391000040	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
359391000041	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
359391000042	Walker A/P-loop; other site
359391000043	ATP binding site [chemical binding]; other site
359391000044	Q-loop/lid; other site
359391000045	ABC transporter signature motif; other site
359391000046	Walker B; other site
359391000047	D-loop; other site
359391000048	H-loop/switch region; other site
359391000049	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
359391000050	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
359391000051	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391000052	dimer interface [polypeptide binding]; other site
359391000053	conserved gate region; other site
359391000054	putative PBP binding loops; other site
359391000055	ABC-ATPase subunit interface; other site
359391000056	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
359391000057	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391000058	dimer interface [polypeptide binding]; other site
359391000059	conserved gate region; other site
359391000060	putative PBP binding loops; other site
359391000061	ABC-ATPase subunit interface; other site
359391000062	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
359391000063	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
359391000064	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
359391000065	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
359391000066	Leu/Ile/Val-binding protein family:Extracellular ligand-binding receptor
359391000067	enoyl-CoA hydratase; Provisional; Region: PRK07468
359391000068	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
359391000069	substrate binding site [chemical binding]; other site
359391000070	oxyanion hole (OAH) forming residues; other site
359391000071	trimer interface [polypeptide binding]; other site
359391000072	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
359391000073	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
359391000074	active site
359391000075	catalytic residues [active]
359391000076	metal binding site [ion binding]; metal-binding site
359391000077	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
359391000078	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
359391000079	ATP-grasp domain; Region: ATP-grasp_4; cl17255
359391000080	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
359391000081	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
359391000082	carboxyltransferase (CT) interaction site; other site
359391000083	biotinylation site [posttranslational modification]; other site
359391000084	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
359391000085	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
359391000086	Acyl-CoA dehydrogenase:Acyl-CoA dehydrogenase, C-terminal:Acyl-CoA dehydrogenase, central domain
359391000087	Acyltransferase 3 family
359391000088	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4530
359391000089	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
359391000090	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
359391000091	hinge; other site
359391000092	active site
359391000093	cytidylate kinase; Provisional; Region: cmk; PRK00023
359391000094	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
359391000095	CMP-binding site; other site
359391000096	The sites determining sugar specificity; other site
359391000097	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
359391000098	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
359391000099	RNA binding site [nucleotide binding]; other site
359391000100	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
359391000101	RNA binding site [nucleotide binding]; other site
359391000102	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
359391000103	RNA binding site [nucleotide binding]; other site
359391000104	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
359391000105	RNA binding site [nucleotide binding]; other site
359391000106	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
359391000107	RNA binding site [nucleotide binding]; other site
359391000108	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
359391000109	RNA binding site [nucleotide binding]; other site
359391000110	Predicted membrane protein [Function unknown]; Region: COG2855
359391000111	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
359391000112	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
359391000113	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
359391000114	dimerization interface [polypeptide binding]; other site
359391000115	lytic murein transglycosylase; Region: MltB_2; TIGR02283
359391000116	Transglycosylase SLT domain; Region: SLT_2; pfam13406
359391000117	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
359391000118	N-acetyl-D-glucosamine binding site [chemical binding]; other site
359391000119	recombination protein RecR; Reviewed; Region: recR; PRK00076
359391000120	RecR protein; Region: RecR; pfam02132
359391000121	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
359391000122	putative active site [active]
359391000123	putative metal-binding site [ion binding]; other site
359391000124	tetramer interface [polypeptide binding]; other site
359391000125	hypothetical protein; Validated; Region: PRK00153
359391000126	DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111
359391000127	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
359391000128	Walker A motif; other site
359391000129	ATP binding site [chemical binding]; other site
359391000130	Walker B motif; other site
359391000131	arginine finger; other site
359391000132	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
359391000133	DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362
359391000134	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
359391000135	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
359391000136	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
359391000137	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
359391000138	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
359391000139	putative NADH binding site [chemical binding]; other site
359391000140	putative active site [active]
359391000141	nudix motif; other site
359391000142	putative metal binding site [ion binding]; other site
359391000143	prephenate dehydratase; Provisional; Region: PRK11899
359391000144	Prephenate dehydratase; Region: PDT; pfam00800
359391000145	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
359391000146	putative L-Phe binding site [chemical binding]; other site
359391000147	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
359391000148	Ligand binding site; other site
359391000149	oligomer interface; other site
359391000150	Cytochrome c2 [Energy production and conversion]; Region: COG3474
359391000151	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
359391000152	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
359391000153	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
359391000154	putative MPT binding site; other site
359391000155	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
359391000156	The cupredoxin domain of Ubiquinol oxidase subunit II; Region: CuRO_UO_II; cd04212
359391000157	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
359391000158	Cytochrome c oxidase, subunit I
359391000159	Cytochrome c oxidase, subunit I
359391000160	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
359391000161	Subunit I/III interface [polypeptide binding]; other site
359391000162	Subunit III/IV interface [polypeptide binding]; other site
359391000163	Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125
359391000164	conserved hypothetical protein
359391000165	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
359391000166	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
359391000167	Surface antigen; Region: Bac_surface_Ag; pfam01103
359391000168	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
359391000169	Family of unknown function (DUF490); Region: DUF490; pfam04357
359391000170	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
359391000171	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
359391000172	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
359391000173	Copper(I)-binding protein [Inorganic ion transport and    metabolism]; Region: COG2847
359391000174	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
359391000175	dimer interface [polypeptide binding]; other site
359391000176	active site
359391000177	metal binding site [ion binding]; metal-binding site
359391000178	glutathione binding site [chemical binding]; other site
359391000179	Domain of unknown function DUF59; Region: DUF59; pfam01883
359391000180	cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969
359391000181	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
359391000182	Walker A motif; other site
359391000183	phosphoglucomutase; Region: PLN02307
359391000184	Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085
359391000185	substrate binding site [chemical binding]; other site
359391000186	dimer interface [polypeptide binding]; other site
359391000187	active site
359391000188	metal binding site [ion binding]; metal-binding site
359391000189	Transcriptional regulator [Transcription]; Region: LysR; COG0583
359391000190	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
359391000191	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
359391000192	putative effector binding pocket; other site
359391000193	putative dimerization interface [polypeptide binding]; other site
359391000194	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
359391000195	nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270
359391000196	active site
359391000197	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
359391000198	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
359391000199	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
359391000200	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
359391000201	N-acetyl-D-glucosamine binding site [chemical binding]; other site
359391000202	catalytic residue [active]
359391000203	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
359391000204	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
359391000205	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
359391000206	putative active site [active]
359391000207	putative PHP Thumb interface [polypeptide binding]; other site
359391000208	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
359391000209	Helix-hairpin-helix motif; Region: HHH_6; pfam14579
359391000210	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
359391000211	generic binding surface II; other site
359391000212	generic binding surface I; other site
359391000213	DNA Polymerase Y-family; Region: PolY_like; cd03468
359391000214	active site
359391000215	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
359391000216	DNA binding site [nucleotide binding]
359391000217	Uncharacterized conserved protein [Function unknown]; Region: COG4544
359391000218	Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295
359391000219	Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295
359391000220	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
359391000221	trimer interface [polypeptide binding]; other site
359391000222	Coiled stalk of trimeric autotransporter adhesin; Region: YadA_stalk; pfam05662
359391000223	YadA-like C-terminal region; Region: YadA_anchor; pfam03895
359391000224	Invasion associated locus B (IalB) protein; Region: IalB; cl02207
359391000225	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
359391000226	ANP binding site [chemical binding]; other site
359391000227	Substrate Binding Site II [chemical binding]; other site
359391000228	Substrate Binding Site I [chemical binding]; other site
359391000229	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
359391000230	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
359391000231	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
359391000232	FeS/SAM binding site; other site
359391000233	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
359391000234	Invasion associated locus B (IalB) protein; Region: IalB; cl02207
359391000235	Uncharacterized conserved protein [Function unknown]; Region: COG3339
359391000236	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914
359391000237	aromatic arch; other site
359391000238	DCoH dimer interaction site [polypeptide binding]; other site
359391000239	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
359391000240	DCoH tetramer interaction site [polypeptide binding]; other site
359391000241	substrate binding site [chemical binding]; other site
359391000242	Low molecular weight phosphotyrosine protein phosphatase
359391000243	Low molecular weight phosphotyrosine protein phosphatase:Mammalian LMW phosphotyrosine protein phosphatase
359391000244	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
359391000245	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
359391000246	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
359391000247	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
359391000248	active site
359391000249	catalytic triad [active]
359391000250	oxyanion hole [active]
359391000251	switch loop; other site
359391000252	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
359391000253	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
359391000254	Walker A/P-loop; other site
359391000255	ATP binding site [chemical binding]; other site
359391000256	Q-loop/lid; other site
359391000257	ABC transporter signature motif; other site
359391000258	Walker B; other site
359391000259	D-loop; other site
359391000260	H-loop/switch region; other site
359391000261	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
359391000262	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
359391000263	FtsX-like permease family; Region: FtsX; pfam02687
359391000264	FtsX-like permease family; Region: FtsX; pfam02687
359391000265	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
359391000266	phosphinothricin N-acetyltransferase
359391000267	phosphinothricin N-acetyltransferase
359391000268	Protein of unknown function (DUF2794); Region: DUF2794; pfam10984
359391000269	Uncharacterized secreted protein [Function unknown]; Region: COG5429
359391000270	aconitate hydratase; Validated; Region: PRK09277
359391000271	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
359391000272	substrate binding site [chemical binding]; other site
359391000273	ligand binding site [chemical binding]; other site
359391000274	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
359391000275	substrate binding site [chemical binding]; other site
359391000276	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539
359391000277	Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231
359391000278	Walker A/P-loop; other site
359391000279	ATP binding site [chemical binding]; other site
359391000280	Q-loop/lid; other site
359391000281	ABC transporter signature motif; other site
359391000282	Walker B; other site
359391000283	D-loop; other site
359391000284	H-loop/switch region; other site
359391000285	ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmB; COG2386
359391000286	heme exporter protein CcmC; Region: ccmC; TIGR01191
359391000287	heme exporter protein CcmD; Region: cytochro_ccmD; TIGR03141
359391000288	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
359391000289	catalytic residues [active]
359391000290	central insert; other site
359391000291	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
359391000292	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
359391000293	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078
359391000294	active site
359391000295	phosphorylation site [posttranslational modification]
359391000296	intermolecular recognition site; other site
359391000297	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
359391000298	AsnC family; Region: AsnC_trans_reg; pfam01037
359391000299	Domain of Unknown Function (DUF930); Region: DUF930; pfam06059
359391000300	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604
359391000301	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
359391000302	putative active site [active]
359391000303	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
359391000304	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
359391000305	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391000306	dimer interface [polypeptide binding]; other site
359391000307	conserved gate region; other site
359391000308	putative PBP binding loops; other site
359391000309	ABC-ATPase subunit interface; other site
359391000310	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391000311	dimer interface [polypeptide binding]; other site
359391000312	conserved gate region; other site
359391000313	putative PBP binding loops; other site
359391000314	ABC-ATPase subunit interface; other site
359391000315	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
359391000316	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
359391000317	Walker A/P-loop; other site
359391000318	ATP binding site [chemical binding]; other site
359391000319	Q-loop/lid; other site
359391000320	ABC transporter signature motif; other site
359391000321	Walker B; other site
359391000322	D-loop; other site
359391000323	H-loop/switch region; other site
359391000324	TOBE-like domain; Region: TOBE_3; pfam12857
359391000325	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
359391000326	Protein of unknown function (DUF3131); Region: DUF3131; pfam11329
359391000327	Putative glucoamylase; Region: Glycoamylase; pfam10091
359391000328	Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753
359391000329	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
359391000330	First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756
359391000331	Protein of unknown function, DUF608; Region: DUF608; pfam04685
359391000332	Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488
359391000333	nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321
359391000334	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
359391000335	Diaminopimelate epimerase; Region: DAP_epimerase; cl19724
359391000336	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
359391000337	S-adenosylmethionine binding site [chemical binding]; other site
359391000338	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
359391000339	putative substrate binding site [chemical binding]; other site
359391000340	putative ATP binding site [chemical binding]; other site
359391000341	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
359391000342	classical (c) SDRs; Region: SDR_c; cd05233
359391000343	NAD(P) binding site [chemical binding]; other site
359391000344	active site
359391000345	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
359391000346	Transglycosylase; Region: Transgly; pfam00912
359391000347	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
359391000348	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
359391000349	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
359391000350	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
359391000351	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
359391000352	catalytic site [active]
359391000353	putative active site [active]
359391000354	putative substrate binding site [chemical binding]; other site
359391000355	hypothetical protein; Validated; Region: PRK09104
359391000356	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
359391000357	metal binding site [ion binding]; metal-binding site
359391000358	putative dimer interface [polypeptide binding]; other site
359391000359	DNA polymerase I; Provisional; Region: PRK05755
359391000360	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
359391000361	active site
359391000362	metal binding site 1 [ion binding]; metal-binding site
359391000363	putative 5' ssDNA interaction site; other site
359391000364	metal binding site 3; metal-binding site
359391000365	metal binding site 2 [ion binding]; metal-binding site
359391000366	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
359391000367	putative DNA binding site [nucleotide binding]; other site
359391000368	putative metal binding site [ion binding]; other site
359391000369	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
359391000370	active site
359391000371	catalytic site [active]
359391000372	substrate binding site [chemical binding]; other site
359391000373	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
359391000374	active site
359391000375	DNA binding site [nucleotide binding]
359391000376	catalytic site [active]
359391000377	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
359391000378	DEAD-like helicases superfamily; Region: DEXDc; smart00487
359391000379	ATP binding site [chemical binding]; other site
359391000380	Mg++ binding site [ion binding]; other site
359391000381	motif III; other site
359391000382	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
359391000383	nucleotide binding region [chemical binding]; other site
359391000384	ATP-binding site [chemical binding]; other site
359391000385	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
359391000386	RNA binding site [nucleotide binding]; other site
359391000387	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
359391000388	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
359391000389	ATP binding site [chemical binding]; other site
359391000390	Mg2+ binding site [ion binding]; other site
359391000391	G-X-G motif; other site
359391000392	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
359391000393	anchoring element; other site
359391000394	dimer interface [polypeptide binding]; other site
359391000395	ATP binding site [chemical binding]; other site
359391000396	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
359391000397	active site
359391000398	putative metal-binding site [ion binding]; other site
359391000399	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
359391000400	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187
359391000401	Putative esterase; Region: Esterase; pfam00756
359391000402	TonB-dependent receptor protein
359391000403	conserved hypothetical protein
359391000404	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
359391000405	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
359391000406	Coenzyme A binding pocket [chemical binding]; other site
359391000407	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
359391000408	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
359391000409	substrate binding site [chemical binding]; other site
359391000410	catalytic Zn binding site [ion binding]; other site
359391000411	NAD binding site [chemical binding]; other site
359391000412	structural Zn binding site [ion binding]; other site
359391000413	dimer interface [polypeptide binding]; other site
359391000414	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
359391000415	putative homodimer interface [polypeptide binding]; other site
359391000416	putative homotetramer interface [polypeptide binding]; other site
359391000417	putative metal binding site [ion binding]; other site
359391000418	putative homodimer-homodimer interface [polypeptide binding]; other site
359391000419	putative allosteric switch controlling residues; other site
359391000420	DEAD/DEAH box helicase:Helicase, C-terminal:ATP/GTP-binding site motif A (P-loop):Helicase-associated region
359391000421	ATP-dependent helicase HrpB
359391000422	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
359391000423	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
359391000424	phosphorylation site [posttranslational modification]
359391000425	dimer interface [polypeptide binding]; other site
359391000426	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
359391000427	ATP binding site [chemical binding]; other site
359391000428	Mg2+ binding site [ion binding]; other site
359391000429	G-X-G motif; other site
359391000430	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
359391000431	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
359391000432	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
359391000433	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
359391000434	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
359391000435	active site
359391000436	phosphorylation site [posttranslational modification]
359391000437	intermolecular recognition site; other site
359391000438	dimerization interface [polypeptide binding]; other site
359391000439	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
359391000440	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5321
359391000441	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
359391000442	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
359391000443	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
359391000444	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
359391000445	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
359391000446	Ligand Binding Site [chemical binding]; other site
359391000447	tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927
359391000448	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
359391000449	active site
359391000450	HIGH motif; other site
359391000451	dimer interface [polypeptide binding]; other site
359391000452	KMSKS motif; other site
359391000453	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
359391000454	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
359391000455	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
359391000456	PII uridylyl-transferase; Provisional; Region: PRK05092
359391000457	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
359391000458	metal binding triad; other site
359391000459	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
359391000460	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
359391000461	Zn2+ binding site [ion binding]; other site
359391000462	Mg2+ binding site [ion binding]; other site
359391000463	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
359391000464	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
359391000465	Phosphate acetyl/butaryl transferase
359391000466	Malic oxidoreductase
359391000467	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
359391000468	MutS domain I; Region: MutS_I; pfam01624
359391000469	MutS domain II; Region: MutS_II; pfam05188
359391000470	MutS domain III; Region: MutS_III; pfam05192
359391000471	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
359391000472	Walker A/P-loop; other site
359391000473	ATP binding site [chemical binding]; other site
359391000474	Q-loop/lid; other site
359391000475	ABC transporter signature motif; other site
359391000476	Walker B; other site
359391000477	D-loop; other site
359391000478	H-loop/switch region; other site
359391000479	Putative hemolysin [General function prediction only]; Region: COG3176
359391000480	lipoprotein signal peptidase; Provisional; Region: PRK14795
359391000481	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
359391000482	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
359391000483	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
359391000484	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
359391000485	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
359391000486	S-adenosylmethionine binding site [chemical binding]; other site
359391000487	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
359391000488	Beta subunit of integration host factor (IHFB); Region: IHF_B; cd13836
359391000489	dimer interface [polypeptide binding]; other site
359391000490	DNA binding site [nucleotide binding]
359391000491	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
359391000492	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
359391000493	tandem repeat interface [polypeptide binding]; other site
359391000494	oligomer interface [polypeptide binding]; other site
359391000495	active site residues [active]
359391000496	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375
359391000497	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934
359391000498	OstA-like protein; Region: OstA; pfam03968
359391000499	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
359391000500	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
359391000501	Walker A/P-loop; other site
359391000502	ATP binding site [chemical binding]; other site
359391000503	Q-loop/lid; other site
359391000504	ABC transporter signature motif; other site
359391000505	Walker B; other site
359391000506	D-loop; other site
359391000507	H-loop/switch region; other site
359391000508	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
359391000509	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
359391000510	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
359391000511	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
359391000512	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
359391000513	30S subunit binding site; other site
359391000514	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
359391000515	active site
359391000516	phosphorylation site [posttranslational modification]
359391000517	Uncharacterized small protein [Function unknown]; Region: COG5568
359391000518	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
359391000519	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
359391000520	putative dimer interface [polypeptide binding]; other site
359391000521	Integral membrane protein [Function unknown]; Region: COG5488
359391000522	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
359391000523	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
359391000524	minor groove reading motif; other site
359391000525	helix-hairpin-helix signature motif; other site
359391000526	substrate binding pocket [chemical binding]; other site
359391000527	active site
359391000528	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
359391000529	CysZ-like protein; Reviewed; Region: PRK12768
359391000530	adenosine kinase; Provisional; Region: PTZ00247
359391000531	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
359391000532	substrate binding site [chemical binding]; other site
359391000533	ATP binding site [chemical binding]; other site
359391000534	Predicted membrane protein [Function unknown]; Region: COG2860
359391000535	UPF0126 domain; Region: UPF0126; pfam03458
359391000536	UPF0126 domain; Region: UPF0126; pfam03458
359391000537	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
359391000538	dimer interface [polypeptide binding]; other site
359391000539	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
359391000540	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
359391000541	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
359391000542	HrcA protein C terminal domain; Region: HrcA; pfam01628
359391000543	ribonuclease PH; Reviewed; Region: rph; PRK00173
359391000544	Ribonuclease PH; Region: RNase_PH_bact; cd11362
359391000545	hexamer interface [polypeptide binding]; other site
359391000546	active site
359391000547	lactoylglutathione lyase, putative
359391000548	lactoylglutathione lyase, putative
359391000549	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
359391000550	active site
359391000551	dimerization interface [polypeptide binding]; other site
359391000552	coproporphyrinogen III oxidase; Provisional; Region: PRK09057
359391000553	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
359391000554	FeS/SAM binding site; other site
359391000555	HemN C-terminal domain; Region: HemN_C; pfam06969
359391000556	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
359391000557	putative SAM binding site [chemical binding]; other site
359391000558	putative homodimer interface [polypeptide binding]; other site
359391000559	Predicted endonuclease distantly related to archaeal Holliday junction resolvase [DNA replication, recombination, and repair]; Region: COG0792
359391000560	siroheme synthase; Provisional; Region: cysG; PRK10637
359391000561	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
359391000562	Sirohaem synthase dimerization region; Region: CysG_dimeriser; pfam10414
359391000563	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
359391000564	active site
359391000565	SAM binding site [chemical binding]; other site
359391000566	homodimer interface [polypeptide binding]; other site
359391000567	Protein of unknown function (DUF2849); Region: DUF2849; pfam11011
359391000568	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
359391000569	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
359391000570	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
359391000571	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
359391000572	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
359391000573	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
359391000574	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
359391000575	Active Sites [active]
359391000576	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3749
359391000577	Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876
359391000578	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
359391000579	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
359391000580	active site
359391000581	DNA binding site [nucleotide binding]
359391000582	BA14K-like protein; Region: BA14K; pfam07886
359391000583	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
359391000584	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
359391000585	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
359391000586	substrate binding pocket [chemical binding]; other site
359391000587	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
359391000588	B12 binding site [chemical binding]; other site
359391000589	cobalt ligand [ion binding]; other site
359391000590	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
359391000591	Dehydratase family; Region: ILVD_EDD; cl00340
359391000592	DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188
359391000593	Autoinducer binding domain; Region: Autoind_bind; pfam03472
359391000594	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
359391000595	DNA binding residues [nucleotide binding]
359391000596	dimerization interface [polypeptide binding]; other site
359391000597	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
359391000598	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
359391000599	inhibitor-cofactor binding pocket; inhibition site
359391000600	pyridoxal 5'-phosphate binding site [chemical binding]; other site
359391000601	catalytic residue [active]
359391000602	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
359391000603	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
359391000604	Active Sites [active]
359391000605	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
359391000606	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
359391000607	CysD dimerization site [polypeptide binding]; other site
359391000608	G1 box; other site
359391000609	putative GEF interaction site [polypeptide binding]; other site
359391000610	GTP/Mg2+ binding site [chemical binding]; other site
359391000611	Switch I region; other site
359391000612	G2 box; other site
359391000613	G3 box; other site
359391000614	Switch II region; other site
359391000615	G4 box; other site
359391000616	G5 box; other site
359391000617	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
359391000618	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
359391000619	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
359391000620	ligand-binding site [chemical binding]; other site
359391000621	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
359391000622	active site
359391000623	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
359391000624	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
359391000625	ligand binding site [chemical binding]; other site
359391000626	flexible hinge region; other site
359391000627	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
359391000628	putative switch regulator; other site
359391000629	non-specific DNA interactions [nucleotide binding]; other site
359391000630	DNA binding site [nucleotide binding]
359391000631	sequence specific DNA binding site [nucleotide binding]; other site
359391000632	putative cAMP binding site [chemical binding]; other site
359391000633	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
359391000634	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078
359391000635	active site
359391000636	dimerization interface [polypeptide binding]; other site
359391000637	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
359391000638	DNA binding residues [nucleotide binding]
359391000639	dimerization interface [polypeptide binding]; other site
359391000640	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
359391000641	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
359391000642	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
359391000643	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
359391000644	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
359391000645	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
359391000646	GAF domain; Region: GAF; pfam01590
359391000647	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
359391000648	Aldehyde dehydrogenase
359391000649	Aldehyde dehydrogenase
359391000650	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
359391000651	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
359391000652	NAD binding site [chemical binding]; other site
359391000653	substrate binding site [chemical binding]; other site
359391000654	catalytic Zn binding site [ion binding]; other site
359391000655	tetramer interface [polypeptide binding]; other site
359391000656	structural Zn binding site [ion binding]; other site
359391000657	conserved hypothetical protein
359391000658	Transcriptional regulators [Transcription]; Region: PurR; COG1609
359391000659	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
359391000660	DNA binding site [nucleotide binding]
359391000661	domain linker motif; other site
359391000662	Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545
359391000663	putative dimerization interface [polypeptide binding]; other site
359391000664	putative ligand binding site [chemical binding]; other site
359391000665	ABC transporter
359391000666	ABC transporter ATP-binding protein
359391000667	ABC transporter, transmembrane region:Bacterial general secretion pathway protein F
359391000668	Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097
359391000669	NAD(P) binding site [chemical binding]; other site
359391000670	catalytic residues [active]
359391000671	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
359391000672	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391000673	dimer interface [polypeptide binding]; other site
359391000674	conserved gate region; other site
359391000675	putative PBP binding loops; other site
359391000676	ABC-ATPase subunit interface; other site
359391000677	Putative transcription activator [Transcription]; Region: TenA; COG0819
359391000678	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
359391000679	NMT1/THI5 like; Region: NMT1; pfam09084
359391000680	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
359391000681	active site
359391000682	thiamine phosphate binding site [chemical binding]; other site
359391000683	pyrophosphate binding site [ion binding]; other site
359391000684	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
359391000685	ThiS interaction site; other site
359391000686	putative active site [active]
359391000687	tetramer interface [polypeptide binding]; other site
359391000688	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
359391000689	thiS-thiF/thiG interaction site; other site
359391000690	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
359391000691	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126
359391000692	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
359391000693	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
359391000694	dimer interface [polypeptide binding]; other site
359391000695	substrate binding site [chemical binding]; other site
359391000696	ATP binding site [chemical binding]; other site
359391000697	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
359391000698	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
359391000699	putative active site [active]
359391000700	heme pocket [chemical binding]; other site
359391000701	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
359391000702	putative active site [active]
359391000703	heme pocket [chemical binding]; other site
359391000704	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
359391000705	metal binding site [ion binding]; metal-binding site
359391000706	active site
359391000707	I-site; other site
359391000708	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
359391000709	Cation-transporting ATPase A, P type:H+ transporting ATPase, proton pump:Cadmium-transporting ATPase:Copper-transporting ATPa...
359391000710	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
359391000711	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
359391000712	DNA binding residues [nucleotide binding]
359391000713	dimer interface [polypeptide binding]; other site
359391000714	copper binding site [ion binding]; other site
359391000715	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391000716	dimer interface [polypeptide binding]; other site
359391000717	conserved gate region; other site
359391000718	putative PBP binding loops; other site
359391000719	ABC-ATPase subunit interface; other site
359391000720	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
359391000721	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
359391000722	Walker A/P-loop; other site
359391000723	ATP binding site [chemical binding]; other site
359391000724	Q-loop/lid; other site
359391000725	ABC transporter signature motif; other site
359391000726	Walker B; other site
359391000727	D-loop; other site
359391000728	H-loop/switch region; other site
359391000729	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
359391000730	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391000731	dimer interface [polypeptide binding]; other site
359391000732	conserved gate region; other site
359391000733	putative PBP binding loops; other site
359391000734	ABC-ATPase subunit interface; other site
359391000735	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
359391000736	Uncharacterized conserved protein [Function unknown]; Region: COG5514
359391000737	heme-binding site [chemical binding]; other site
359391000738	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
359391000739	Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812
359391000740	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
359391000741	NAD(P) binding site [chemical binding]; other site
359391000742	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
359391000743	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
359391000744	Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311
359391000745	possible sarcosine oxidase alpha subunit
359391000746	Pyridine nucleotide-disulphide oxidoreductase, class-II:NAD binding site:Adrenodoxin reductase:Pyridine nucleotide-disulphide...
359391000747	Glycine cleavage T protein (aminomethyl transferase)
359391000748	Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583
359391000749	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
359391000750	active site
359391000751	Transcriptional regulator [Transcription]; Region: IclR; COG1414
359391000752	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
359391000753	Bacterial transcriptional regulator; Region: IclR; pfam01614
359391000754	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
359391000755	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
359391000756	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
359391000757	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391000758	dimer interface [polypeptide binding]; other site
359391000759	conserved gate region; other site
359391000760	putative PBP binding loops; other site
359391000761	ABC-ATPase subunit interface; other site
359391000762	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
359391000763	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391000764	dimer interface [polypeptide binding]; other site
359391000765	conserved gate region; other site
359391000766	putative PBP binding loops; other site
359391000767	ABC-ATPase subunit interface; other site
359391000768	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
359391000769	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
359391000770	Walker A/P-loop; other site
359391000771	ATP binding site [chemical binding]; other site
359391000772	Q-loop/lid; other site
359391000773	ABC transporter signature motif; other site
359391000774	Walker B; other site
359391000775	D-loop; other site
359391000776	H-loop/switch region; other site
359391000777	TOBE domain; Region: TOBE_2; pfam08402
359391000778	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
359391000779	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
359391000780	active site pocket [active]
359391000781	Uncharacterized conserved protein [Function unknown]; Region: COG3254
359391000782	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
359391000783	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
359391000784	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
359391000785	human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368
359391000786	NAD binding site [chemical binding]; other site
359391000787	homotetramer interface [polypeptide binding]; other site
359391000788	homodimer interface [polypeptide binding]; other site
359391000789	active site
359391000790	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
359391000791	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
359391000792	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
359391000793	Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324
359391000794	putative active site pocket [active]
359391000795	metal binding site [ion binding]; metal-binding site
359391000796	integrase; Provisional; Region: PRK09692
359391000797	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
359391000798	active site
359391000799	Int/Topo IB signature motif; other site
359391000800	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
359391000801	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
359391000802	active site
359391000803	metal binding site [ion binding]; metal-binding site
359391000804	interdomain interaction site; other site
359391000805	conserved hypothetical protein
359391000806	conserved hypothetical protein
359391000807	Condensation domain; Region: Condensation; cl19241
359391000808	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
359391000809	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
359391000810	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
359391000812	conserved hypothetical protein
359391000813	'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The...; Region: SANT; cd00167
359391000814	DNA binding site [nucleotide binding]
359391000815	Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856
359391000816	Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253
359391000817	Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253
359391000818	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
359391000819	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
359391000820	non-specific DNA binding site [nucleotide binding]; other site
359391000821	salt bridge; other site
359391000822	sequence-specific DNA binding site [nucleotide binding]; other site
359391000823	GcrA cell cycle regulator; Region: GcrA; cl11564
359391000824	TIR domain; Region: TIR_2; pfam13676
359391000825	zinc-binding protein; Provisional; Region: PRK01343
359391000826	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
359391000827	active site
359391000828	dimer interface [polypeptide binding]; other site
359391000829	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
359391000830	rRNA binding site [nucleotide binding]; other site
359391000831	predicted 30S ribosome binding site; other site
359391000832	Low molecular weight phosphatase family; Region: LMWPc; cd00115
359391000833	active site
359391000834	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5328
359391000835	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
359391000836	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
359391000837	NAD binding site [chemical binding]; other site
359391000838	dimerization interface [polypeptide binding]; other site
359391000839	product binding site; other site
359391000840	substrate binding site [chemical binding]; other site
359391000841	zinc binding site [ion binding]; other site
359391000842	catalytic residues [active]
359391000843	Protein of unknown function (DUF2948); Region: DUF2948; pfam11164
359391000844	EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275
359391000845	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
359391000846	hinge; other site
359391000847	active site
359391000848	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
359391000849	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
359391000850	INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184
359391000851	Int/Topo IB signature motif; other site
359391000852	BRO family protein
359391000853	BRO family protein
359391000854	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
359391000855	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
359391000856	catalytic residues [active]
359391000857	catalytic nucleophile [active]
359391000858	Presynaptic Site I dimer interface [polypeptide binding]; other site
359391000859	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
359391000860	Synaptic Flat tetramer interface [polypeptide binding]; other site
359391000861	Synaptic Site I dimer interface [polypeptide binding]; other site
359391000862	DNA binding site [nucleotide binding]
359391000863	conserved hypothetical protein
359391000864	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
359391000865	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
359391000866	non-specific DNA binding site [nucleotide binding]; other site
359391000867	salt bridge; other site
359391000868	sequence-specific DNA binding site [nucleotide binding]; other site
359391000869	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cl00541
359391000870	dimerization interface [polypeptide binding]; other site
359391000871	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
359391000872	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
359391000873	alpha-gamma subunit interface [polypeptide binding]; other site
359391000874	beta-gamma subunit interface [polypeptide binding]; other site
359391000875	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
359391000876	gamma-beta subunit interface [polypeptide binding]; other site
359391000877	alpha-beta subunit interface [polypeptide binding]; other site
359391000878	urease subunit alpha; Reviewed; Region: ureC; PRK13207
359391000879	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
359391000880	subunit interactions [polypeptide binding]; other site
359391000881	active site
359391000882	flap region; other site
359391000883	Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371
359391000884	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
359391000885	dimer interface [polypeptide binding]; other site
359391000886	catalytic residues [active]
359391000887	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
359391000888	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
359391000889	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
359391000890	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
359391000891	ATP binding site [chemical binding]; other site
359391000892	Mg2+ binding site [ion binding]; other site
359391000893	G-X-G motif; other site
359391000894	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
359391000895	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
359391000896	HlyD family secretion protein; Region: HlyD_3; pfam13437
359391000897	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
359391000898	MMPL family; Region: MMPL; cl14618
359391000899	MMPL family; Region: MMPL; cl14618
359391000900	D-hydantoinase
359391000901	Amidohydrolase
359391000902	allantoate amidohydrolase; Reviewed; Region: PRK12893
359391000903	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
359391000904	active site
359391000905	metal binding site [ion binding]; metal-binding site
359391000906	dimer interface [polypeptide binding]; other site
359391000907	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
359391000908	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
359391000909	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
359391000910	NUDIX hydrolase
359391000911	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
359391000912	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
359391000913	homodimer interface [polypeptide binding]; other site
359391000914	active site
359391000915	FMN binding site [chemical binding]; other site
359391000916	substrate binding site [chemical binding]; other site
359391000917	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
359391000918	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
359391000919	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691
359391000920	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
359391000921	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
359391000922	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
359391000923	putative hydrophobic ligand binding site [chemical binding]; other site
359391000924	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
359391000925	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
359391000926	active site
359391000927	dimer interface [polypeptide binding]; other site
359391000928	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
359391000929	dimer interface [polypeptide binding]; other site
359391000930	active site
359391000931	Predicted deacylase [General function prediction only]; Region: COG3608
359391000932	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250
359391000933	active site
359391000934	Zn binding site [ion binding]; other site
359391000935	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
359391000936	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
359391000937	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
359391000938	motif II; other site
359391000939	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
359391000940	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
359391000941	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
359391000942	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
359391000943	acyl-activating enzyme (AAE) consensus motif; other site
359391000944	putative AMP binding site [chemical binding]; other site
359391000945	putative active site [active]
359391000946	putative CoA binding site [chemical binding]; other site
359391000947	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
359391000948	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
359391000949	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
359391000950	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
359391000951	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
359391000952	HlyD family secretion protein; Region: HlyD_3; pfam13437
359391000953	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
359391000954	MMPL family; Region: MMPL; cl14618
359391000955	MMPL family; Region: MMPL; cl14618
359391000956	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
359391000957	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
359391000958	substrate binding pocket [chemical binding]; other site
359391000959	membrane-bound complex binding site; other site
359391000960	hinge residues; other site
359391000961	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
359391000962	CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427
359391000963	DXD motif; other site
359391000964	Uncharacterized conserved protein [Function unknown]; Region: COG2326
359391000965	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
359391000966	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
359391000967	dimer interface [polypeptide binding]; other site
359391000968	phosphorylation site [posttranslational modification]
359391000969	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
359391000970	ATP binding site [chemical binding]; other site
359391000971	Mg2+ binding site [ion binding]; other site
359391000972	G-X-G motif; other site
359391000973	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5352
359391000974	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
359391000975	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
359391000976	inhibitor-cofactor binding pocket; inhibition site
359391000977	pyridoxal 5'-phosphate binding site [chemical binding]; other site
359391000978	catalytic residue [active]
359391000979	ornithine carbamoyltransferase; Provisional; Region: PRK00779
359391000980	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
359391000981	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
359391000982	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
359391000983	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
359391000984	dimerization interface [polypeptide binding]; other site
359391000985	domain crossover interface; other site
359391000986	redox-dependent activation switch; other site
359391000987	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
359391000988	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
359391000989	homodimer interface [polypeptide binding]; other site
359391000990	substrate-cofactor binding pocket; other site
359391000991	pyridoxal 5'-phosphate binding site [chemical binding]; other site
359391000992	catalytic residue [active]
359391000993	2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559
359391000994	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
359391000995	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
359391000996	trimer interface [polypeptide binding]; other site
359391000997	active site
359391000998	Deoxycytidine deaminase [Nucleotide transport and metabolism]; Region: Dcd; COG0717
359391000999	trimer interface [polypeptide binding]; other site
359391001000	active site
359391001001	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
359391001002	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
359391001003	conserved cys residue [active]
359391001004	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
359391001005	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
359391001006	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
359391001007	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
359391001008	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
359391001009	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
359391001010	quinone interaction residues [chemical binding]; other site
359391001011	active site
359391001012	catalytic residues [active]
359391001013	FMN binding site [chemical binding]; other site
359391001014	substrate binding site [chemical binding]; other site
359391001015	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502
359391001016	Putative lysophospholipase; Region: Hydrolase_4; cl19140
359391001017	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
359391001018	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
359391001019	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
359391001020	active site
359391001021	phosphorylation site [posttranslational modification]
359391001022	intermolecular recognition site; other site
359391001023	dimerization interface [polypeptide binding]; other site
359391001024	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
359391001025	DNA binding residues [nucleotide binding]
359391001026	dimerization interface [polypeptide binding]; other site
359391001027	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
359391001028	Na binding site [ion binding]; other site
359391001029	PAS domain; Region: PAS; smart00091
359391001030	PAS fold; Region: PAS_7; pfam12860
359391001031	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
359391001032	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
359391001033	dimer interface [polypeptide binding]; other site
359391001034	phosphorylation site [posttranslational modification]
359391001035	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
359391001036	ATP binding site [chemical binding]; other site
359391001037	Mg2+ binding site [ion binding]; other site
359391001038	G-X-G motif; other site
359391001039	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
359391001040	active site
359391001041	phosphorylation site [posttranslational modification]
359391001042	intermolecular recognition site; other site
359391001043	dimerization interface [polypeptide binding]; other site
359391001044	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
359391001045	8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858
359391001046	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
359391001047	substrate-cofactor binding pocket; other site
359391001048	pyridoxal 5'-phosphate binding site [chemical binding]; other site
359391001049	catalytic residue [active]
359391001050	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
359391001051	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
359391001052	putative active site [active]
359391001053	putative metal binding site [ion binding]; other site
359391001054	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
359391001055	Glycosyltransferase family 29 (sialyltransferase); Region: Glyco_transf_29; pfam00777
359391001056	Transcriptional regulator [Transcription]; Region: LysR; COG0583
359391001057	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
359391001058	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
359391001059	putative dimerization interface [polypeptide binding]; other site
359391001060	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
359391001061	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
359391001062	conserved hypothetical protein
359391001063	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782
359391001064	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
359391001065	Pantoate-beta-alanine ligase; Region: PanC; cd00560
359391001066	active site
359391001067	ATP-binding site [chemical binding]; other site
359391001068	pantoate-binding site; other site
359391001069	HXXH motif; other site
359391001070	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
359391001071	active site
359391001072	oligomerization interface [polypeptide binding]; other site
359391001073	metal binding site [ion binding]; metal-binding site
359391001074	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
359391001075	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
359391001076	FAD binding pocket [chemical binding]; other site
359391001077	FAD binding motif [chemical binding]; other site
359391001078	phosphate binding motif [ion binding]; other site
359391001079	beta-alpha-beta structure motif; other site
359391001080	NAD binding pocket [chemical binding]; other site
359391001081	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
359391001082	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
359391001083	dimer interface [polypeptide binding]; other site
359391001084	active site
359391001085	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
359391001086	catalytic residues [active]
359391001087	substrate binding site [chemical binding]; other site
359391001088	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
359391001089	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
359391001090	Proline racemase [Amino acid transport and metabolism]; Region: COG3938
359391001091	hydroxyproline-2-epimerase; Provisional; Region: PRK13971; cl19687
359391001092	Multi antimicrobial extrusion protein MatE
359391001093	Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342
359391001094	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564
359391001095	Cache domain; Region: Cache_2; pfam08269
359391001096	Histidine kinase; Region: HisKA_3; pfam07730
359391001097	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
359391001098	ATP binding site [chemical binding]; other site
359391001099	Mg2+ binding site [ion binding]; other site
359391001100	G-X-G motif; other site
359391001101	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
359391001102	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
359391001103	active site
359391001104	phosphorylation site [posttranslational modification]
359391001105	intermolecular recognition site; other site
359391001106	dimerization interface [polypeptide binding]; other site
359391001107	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
359391001108	DNA binding residues [nucleotide binding]
359391001109	dimerization interface [polypeptide binding]; other site
359391001110	ATP/GTP-binding site motif A (P-loop):Tripartite ATP-independent periplasmic transporters, DctQ component
359391001111	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
359391001112	DctM-like transporters; Region: DctM; pfam06808
359391001113	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
359391001114	hypothetical protein; Provisional; Region: PRK11171
359391001115	Protein of unknown function (DUF861); Region: Cupin_3; pfam05899
359391001116	Cupin domain; Region: Cupin_2; cl17218
359391001117	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
359391001118	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
359391001119	active site
359391001120	catalytic site [active]
359391001121	tetramer interface [polypeptide binding]; other site
359391001122	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195
359391001123	Transthyretin_like.  This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase).  TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl17222
359391001124	homotetramer interface [polypeptide binding]; other site
359391001125	active site
359391001126	Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [Nucleotide transport and metabolism]; Region: XdhA; COG4630
359391001127	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
359391001128	catalytic loop [active]
359391001129	iron binding site [ion binding]; other site
359391001130	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
359391001131	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
359391001132	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
359391001133	Aldehyde oxidase and xanthine dehydrogenase, C-terminal
359391001134	xanthine dehydrogenase
359391001135	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
359391001136	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
359391001137	XdhC Rossmann domain; Region: XdhC_C; pfam13478
359391001138	LysR substrate binding domain
359391001139	Predicted membrane protein [Function unknown]; Region: COG3748
359391001140	Protein of unknown function (DUF989); Region: DUF989; pfam06181
359391001141	Cytochrome c; Region: Cytochrom_C; pfam00034
359391001142	guanine deaminase; Provisional; Region: PRK09228
359391001143	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
359391001144	active site
359391001145	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
359391001146	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
359391001147	MOFRL family; Region: MOFRL; pfam05161
359391001148	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597
359391001149	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
359391001150	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
359391001151	metal-binding site [ion binding]
359391001152	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
359391001153	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
359391001154	motif II; other site
359391001155	Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456
359391001156	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
359391001157	4Fe-4S binding domain; Region: Fer4_5; pfam12801
359391001158	4Fe-4S dicluster domain; Region: Fer4_18; pfam13746
359391001159	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
359391001160	IG-like fold at C-terminal of FixG, putative oxidoreductase; Region: FixG_C; pfam11614
359391001161	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
359391001162	N-terminal domain of cytochrome oxidase-cbb3, FixP; Region: FixP_N; pfam14715
359391001163	Cytochrome c; Region: Cytochrom_C; pfam00034
359391001164	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
359391001165	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324
359391001166	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433
359391001167	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
359391001168	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
359391001169	Low-spin heme binding site [chemical binding]; other site
359391001170	Putative water exit pathway; other site
359391001171	Binuclear center (active site) [active]
359391001172	Putative proton exit pathway; other site
359391001173	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
359391001174	metal binding site 2 [ion binding]; metal-binding site
359391001175	putative DNA binding helix; other site
359391001176	metal binding site 1 [ion binding]; metal-binding site
359391001177	dimer interface [polypeptide binding]; other site
359391001178	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
359391001179	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
359391001180	catalytic residues [active]
359391001181	Aldehyde dehydrogenase
359391001182	hypothetical
359391001183	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
359391001184	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
359391001185	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
359391001186	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
359391001187	DNA binding site [nucleotide binding]
359391001188	active site
359391001189	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
359391001190	putative catalytic residues [active]
359391001191	Predicted membrane protein [Function unknown]; Region: COG4129
359391001192	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
359391001193	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
359391001194	putative substrate translocation pore; other site
359391001195	D-galactonate transporter; Region: 2A0114; TIGR00893
359391001196	microcin B17 transporter; Reviewed; Region: PRK11098
359391001197	Putative catalytic domain of uncharacterized bacterial hypothetical proteins similar to insect chitin deacetylase-like proteins; Region: CE4_CDA_like_3; cd10976
359391001198	NodB motif; other site
359391001199	putative active site [active]
359391001200	putative catalytic site [active]
359391001201	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649
359391001202	GTP-binding protein Der; Reviewed; Region: PRK00093
359391001203	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
359391001204	G1 box; other site
359391001205	GTP/Mg2+ binding site [chemical binding]; other site
359391001206	Switch I region; other site
359391001207	G2 box; other site
359391001208	Switch II region; other site
359391001209	G3 box; other site
359391001210	G4 box; other site
359391001211	G5 box; other site
359391001212	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
359391001213	G1 box; other site
359391001214	GTP/Mg2+ binding site [chemical binding]; other site
359391001215	Switch I region; other site
359391001216	G2 box; other site
359391001217	G3 box; other site
359391001218	Switch II region; other site
359391001219	G4 box; other site
359391001220	G5 box; other site
359391001221	KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714
359391001222	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
359391001223	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
359391001224	nucleotide binding site [chemical binding]; other site
359391001225	putative NEF/HSP70 interaction site [polypeptide binding]; other site
359391001226	SBD interface [polypeptide binding]; other site
359391001227	Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773
359391001228	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
359391001229	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5336
359391001230	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
359391001231	F0F1 ATP synthase subunit C; Validated; Region: PRK07558
359391001232	F0F1 ATP synthase subunit B'; Validated; Region: PRK09174
359391001233	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
359391001234	F0F1 ATP synthase subunit B; Validated; Region: PRK09173
359391001235	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
359391001236	Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
359391001237	RNA/DNA hybrid binding site [nucleotide binding]; other site
359391001238	active site
359391001239	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
359391001240	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
359391001241	FeS/SAM binding site; other site
359391001242	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
359391001243	active site
359391001244	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608
359391001245	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
359391001246	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
359391001247	FHIPEP family; Region: FHIPEP; cl07980
359391001248	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560
359391001249	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
359391001250	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
359391001251	tandem repeat interface [polypeptide binding]; other site
359391001252	oligomer interface [polypeptide binding]; other site
359391001253	active site residues [active]
359391001254	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
359391001255	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
359391001256	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
359391001257	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
359391001258	substrate binding pocket [chemical binding]; other site
359391001259	chain length determination region; other site
359391001260	substrate-Mg2+ binding site; other site
359391001261	catalytic residues [active]
359391001262	aspartate-rich region 1; other site
359391001263	active site lid residues [active]
359391001264	aspartate-rich region 2; other site
359391001265	poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939
359391001266	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
359391001267	binding surface
359391001268	TPR motif; other site
359391001269	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
359391001270	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
359391001271	binding surface
359391001272	TPR motif; other site
359391001273	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
359391001274	binding surface
359391001275	TPR motif; other site
359391001276	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
359391001277	dimer interface [polypeptide binding]; other site
359391001278	motif 1; other site
359391001279	active site
359391001280	motif 2; other site
359391001281	motif 3; other site
359391001282	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
359391001283	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
359391001284	Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092
359391001285	DALR anticodon binding domain; Region: DALR_1; pfam05746
359391001286	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
359391001287	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
359391001288	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
359391001289	FAD binding domain; Region: FAD_binding_4; pfam01565
359391001290	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
359391001291	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
359391001292	Predicted transcriptional regulator [Transcription]; Region: COG3905
359391001293	enoyl-CoA hydratase; Provisional; Region: PRK06023
359391001294	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
359391001295	substrate binding site [chemical binding]; other site
359391001296	oxyanion hole (OAH) forming residues; other site
359391001297	trimer interface [polypeptide binding]; other site
359391001298	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
359391001299	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
359391001300	active site
359391001301	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
359391001302	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
359391001303	metal binding site [ion binding]; metal-binding site
359391001304	active site
359391001305	I-site; other site
359391001306	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
359391001307	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
359391001308	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
359391001309	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
359391001310	4-Hydroxybenzoate polyprenyltransferase; Region: PT_UbiA_COQ2; cd13959
359391001311	putative active site [active]
359391001312	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
359391001313	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
359391001314	Pyridoxine 5'-phosphate oxidase C-terminal dimerization region; Region: PNPOx_C; pfam10590
359391001315	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
359391001316	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
359391001317	HSP70 interaction site [polypeptide binding]; other site
359391001318	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
359391001319	dimer interface [polypeptide binding]; other site
359391001320	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159
359391001321	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
359391001322	NAD binding site [chemical binding]; other site
359391001323	homotetramer interface [polypeptide binding]; other site
359391001324	homodimer interface [polypeptide binding]; other site
359391001325	substrate binding site [chemical binding]; other site
359391001326	active site
359391001327	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
359391001328	catalytic core [active]
359391001329	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
359391001330	DNA-binding site [nucleotide binding]; DNA binding site
359391001331	RNA-binding motif; other site
359391001332	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
359391001333	putative acyl-acceptor binding pocket; other site
359391001334	Protein of unknown function (DUF1344); Region: DUF1344; pfam07076
359391001335	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
359391001336	Tetramer interface [polypeptide binding]; other site
359391001337	active site
359391001338	FMN-binding site [chemical binding]; other site
359391001339	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
359391001340	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09314
359391001341	GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807
359391001342	dimerization interface [polypeptide binding]; other site
359391001343	active site
359391001344	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
359391001345	putative active site [active]
359391001346	Zn binding site [ion binding]; other site
359391001347	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
359391001348	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
359391001349	Predicted membrane protein [Function unknown]; Region: COG2261
359391001350	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3753
359391001351	Pirin-related protein [General function prediction only]; Region: COG1741
359391001352	Pirin; Region: Pirin; pfam02678
359391001353	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
359391001354	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
359391001355	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
359391001356	TPP-binding site; other site
359391001357	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
359391001358	PYR/PP interface [polypeptide binding]; other site
359391001359	dimer interface [polypeptide binding]; other site
359391001360	TPP binding site [chemical binding]; other site
359391001361	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
359391001362	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
359391001363	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
359391001364	RNA binding surface [nucleotide binding]; other site
359391001365	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
359391001366	S-adenosylmethionine binding site [chemical binding]; other site
359391001367	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
359391001368	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
359391001369	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
359391001370	Predicted periplasmic protein [General function prediction only]; Region: COG3895
359391001371	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
359391001372	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
359391001373	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
359391001374	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
359391001375	ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253
359391001376	Walker A/P-loop; other site
359391001377	ATP binding site [chemical binding]; other site
359391001378	Q-loop/lid; other site
359391001379	ABC transporter signature motif; other site
359391001380	Walker B; other site
359391001381	D-loop; other site
359391001382	H-loop/switch region; other site
359391001383	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
359391001384	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
359391001385	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
359391001386	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
359391001387	classical (c) SDRs; Region: SDR_c; cd05233
359391001388	NAD(P) binding site [chemical binding]; other site
359391001389	active site
359391001390	amidophosphoribosyltransferase; Provisional; Region: PRK09123
359391001391	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
359391001392	active site
359391001393	tetramer interface [polypeptide binding]; other site
359391001394	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
359391001395	active site
359391001396	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
359391001397	DNA repair protein RadA; Provisional; Region: PRK11823
359391001398	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
359391001399	Walker A motif; other site
359391001400	ATP binding site [chemical binding]; other site
359391001401	Walker B motif; other site
359391001402	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
359391001403	replicative DNA helicase; Provisional; Region: PRK09165
359391001404	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
359391001405	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
359391001406	Walker A motif; other site
359391001407	ATP binding site [chemical binding]; other site
359391001408	Walker B motif; other site
359391001409	DNA binding loops [nucleotide binding]
359391001410	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
359391001411	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
359391001412	S-adenosylmethionine binding site [chemical binding]; other site
359391001413	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
359391001414	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
359391001415	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
359391001416	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
359391001417	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
359391001418	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
359391001419	3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936
359391001420	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
359391001421	NAD(P) binding site [chemical binding]; other site
359391001422	homotetramer interface [polypeptide binding]; other site
359391001423	homodimer interface [polypeptide binding]; other site
359391001424	active site
359391001425	acyl carrier protein; Provisional; Region: acpP; PRK00982
359391001426	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
359391001427	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
359391001428	dimer interface [polypeptide binding]; other site
359391001429	active site
359391001430	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
359391001431	dimerization interface [polypeptide binding]; other site
359391001432	Uncharacterized stress-induced protein [Function unknown]; Region: COG1561
359391001433	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
359391001434	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
359391001435	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
359391001436	Guanylate kinase; Region: Guanylate_kin; pfam00625
359391001437	catalytic site [active]
359391001438	G-X2-G-X-G-K; other site
359391001439	Putative modulator of DNA gyrase; Region: PmbA_TldD; cl19356
359391001440	Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342
359391001441	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
359391001442	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
359391001443	C-terminal domain of Cytochrome c Oxidase subunit II; Region: CcO_II_C; cd13912
359391001444	subunit II/VIb interface [polypeptide binding]; other site
359391001445	subunit II/VIc interface [polypeptide binding]; other site
359391001446	CuA binding site [ion binding]; other site
359391001447	subunit I/II interface [polypeptide binding]; other site
359391001448	subunit II/IV interface [polypeptide binding]; other site
359391001449	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
359391001450	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
359391001451	Subunit I/III interface [polypeptide binding]; other site
359391001452	D-pathway; other site
359391001453	Subunit I/VIIc interface [polypeptide binding]; other site
359391001454	Subunit I/IV interface [polypeptide binding]; other site
359391001455	Subunit I/II interface [polypeptide binding]; other site
359391001456	Low-spin heme (heme a) binding site [chemical binding]; other site
359391001457	Subunit I/VIIa interface [polypeptide binding]; other site
359391001458	Subunit I/VIa interface [polypeptide binding]; other site
359391001459	Dimer interface; other site
359391001460	Putative water exit pathway; other site
359391001461	Binuclear center (heme a3/CuB) [ion binding]; other site
359391001462	K-pathway; other site
359391001463	Subunit I/Vb interface [polypeptide binding]; other site
359391001464	Putative proton exit pathway; other site
359391001465	Subunit I/VIb interface; other site
359391001466	Subunit I/VIc interface [polypeptide binding]; other site
359391001467	Electron transfer pathway; other site
359391001468	Subunit I/VIIIb interface [polypeptide binding]; other site
359391001469	Subunit I/VIIb interface [polypeptide binding]; other site
359391001470	UbiA prenyltransferase:Protoheme IX farnesyltransferase
359391001471	cytochrome c oxidase assembly protein Ctag KO: K02258 cytochrome c oxidase subunit XI assembly protein
359391001472	cytochrome C oxidase assembly protein CtaG
359391001473	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
359391001474	Subunit III/VIIa interface [polypeptide binding]; other site
359391001475	Phospholipid binding site [chemical binding]; other site
359391001476	Subunit I/III interface [polypeptide binding]; other site
359391001477	Subunit III/VIb interface [polypeptide binding]; other site
359391001478	Subunit III/VIa interface; other site
359391001479	Subunit III/Vb interface [polypeptide binding]; other site
359391001480	zinc-finger protein
359391001481	conserved hypothetical protein
359391001482	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
359391001483	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944
359391001484	Fe-S cluster binding site [ion binding]; other site
359391001485	substrate binding site [chemical binding]; other site
359391001486	catalytic site [active]
359391001487	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
359391001488	Phosphotransferase enzyme family; Region: APH; pfam01636
359391001489	putative active site [active]
359391001490	putative substrate binding site [chemical binding]; other site
359391001491	ATP binding site [chemical binding]; other site
359391001492	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
359391001493	RNA/DNA hybrid binding site [nucleotide binding]; other site
359391001494	active site
359391001495	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
359391001496	catalytic triad [active]
359391001497	dimer interface [polypeptide binding]; other site
359391001498	Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233
359391001499	Putative transcriptional regulator [Transcription]; Region: COG1678
359391001500	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
359391001501	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
359391001502	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
359391001503	putative active site [active]
359391001504	PAS fold; Region: PAS_3; pfam08447
359391001505	heme pocket [chemical binding]; other site
359391001506	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
359391001507	metal binding site [ion binding]; metal-binding site
359391001508	active site
359391001509	I-site; other site
359391001510	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
359391001511	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
359391001512	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
359391001513	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
359391001514	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
359391001515	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
359391001516	threonine synthase; Validated; Region: PRK09225
359391001517	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
359391001518	pyridoxal 5'-phosphate binding site [chemical binding]; other site
359391001519	catalytic residue [active]
359391001520	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
359391001521	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
359391001522	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
359391001523	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
359391001524	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
359391001525	active site
359391001526	motif I; other site
359391001527	motif II; other site
359391001528	putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862
359391001529	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
359391001530	Cl- selectivity filter; other site
359391001531	Cl- binding residues [ion binding]; other site
359391001532	pore gating glutamate residue; other site
359391001533	dimer interface [polypeptide binding]; other site
359391001534	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
359391001535	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
359391001536	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
359391001537	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
359391001538	motif II; other site
359391001539	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
359391001540	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
359391001541	minor groove reading motif; other site
359391001542	helix-hairpin-helix signature motif; other site
359391001543	substrate binding pocket [chemical binding]; other site
359391001544	active site
359391001545	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
359391001546	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
359391001547	DNA binding and oxoG recognition site [nucleotide binding]
359391001548	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5389
359391001549	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
359391001550	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
359391001551	catalytic residues [active]
359391001552	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
359391001553	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
359391001554	Walker A/P-loop; other site
359391001555	ATP binding site [chemical binding]; other site
359391001556	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
359391001557	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
359391001558	ABC transporter signature motif; other site
359391001559	Walker B; other site
359391001560	D-loop; other site
359391001561	H-loop/switch region; other site
359391001562	Cation efflux protein
359391001563	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
359391001564	pyruvate phosphate dikinase; Provisional; Region: PRK09279
359391001565	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
359391001566	PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391
359391001567	PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
359391001568	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
359391001569	Putative catalytic NodB homology domain of uncharacterized BH0857 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH0857_like; cd10955
359391001570	NodB motif; other site
359391001571	putative active site [active]
359391001572	putative catalytic site [active]
359391001573	Protein of unknown function (DUF1499); Region: DUF1499; pfam07386
359391001574	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
359391001575	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
359391001576	ureidoglycolate hydrolase; Provisional; Region: PRK03606
359391001577	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
359391001578	active site
359391001579	homotetramer interface [polypeptide binding]; other site
359391001580	Protein of unknown function (DUF2793); Region: DUF2793; pfam10983
359391001581	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
359391001582	CoA binding domain; Region: CoA_binding; cl17356
359391001583	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
359391001584	NAD(P) binding site [chemical binding]; other site
359391001585	homodimer interface [polypeptide binding]; other site
359391001586	substrate binding site [chemical binding]; other site
359391001587	active site
359391001588	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
359391001589	Mg++ binding site [ion binding]; other site
359391001590	putative catalytic motif [active]
359391001591	putative substrate binding site [chemical binding]; other site
359391001592	Homeodomain-like domain; Region: HTH_23; cl17451
359391001593	Winged helix-turn helix; Region: HTH_29; pfam13551
359391001594	Helix-turn-helix domain; Region: HTH_38; pfam13936
359391001595	HTH-like domain; Region: HTH_21; pfam13276
359391001596	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
359391001597	Integrase core domain; Region: rve; pfam00665
359391001598	Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223
359391001599	Formyltransferase, catalytic core domain; Region: FMT_core; cd08369
359391001600	active site
359391001601	substrate binding site [chemical binding]; other site
359391001602	cosubstrate binding site; other site
359391001603	catalytic site [active]
359391001604	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
359391001605	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
359391001606	Walker A/P-loop; other site
359391001607	ATP binding site [chemical binding]; other site
359391001608	Q-loop/lid; other site
359391001609	ABC transporter signature motif; other site
359391001610	Walker B; other site
359391001611	D-loop; other site
359391001612	H-loop/switch region; other site
359391001613	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
359391001614	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
359391001615	inhibitor-cofactor binding pocket; inhibition site
359391001616	pyridoxal 5'-phosphate binding site [chemical binding]; other site
359391001617	catalytic residue [active]
359391001618	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
359391001619	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
359391001620	NADP-binding site; other site
359391001621	homotetramer interface [polypeptide binding]; other site
359391001622	substrate binding site [chemical binding]; other site
359391001623	homodimer interface [polypeptide binding]; other site
359391001624	active site
359391001625	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
359391001626	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
359391001627	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
359391001628	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
359391001629	Integrase core domain; Region: rve; pfam00665
359391001630	Integrase core domain; Region: rve; pfam00665
359391001631	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
359391001632	Integrase core domain; Region: rve_3; pfam13683
359391001633	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
359391001634	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
359391001635	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
359391001636	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
359391001637	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
359391001638	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
359391001639	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
359391001640	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
359391001641	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
359391001642	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
359391001643	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
359391001644	transposase
359391001645	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
359391001646	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
359391001647	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
359391001648	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
359391001649	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
359391001650	Integrase core domain; Region: rve_3; cl15866
359391001651	ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088
359391001652	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
359391001653	active site
359391001654	substrate binding site [chemical binding]; other site
359391001655	metal binding site [ion binding]; metal-binding site
359391001656	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
359391001657	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
359391001658	Substrate binding site; other site
359391001659	Cupin domain; Region: Cupin_2; cl17218
359391001660	mannose-6-phosphate isomerase
359391001661	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
359391001662	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795
359391001663	putative ADP-binding pocket [chemical binding]; other site
359391001664	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
359391001665	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
359391001666	Walker A/P-loop; other site
359391001667	ATP binding site [chemical binding]; other site
359391001668	Q-loop/lid; other site
359391001669	ABC transporter signature motif; other site
359391001670	Walker B; other site
359391001671	D-loop; other site
359391001672	H-loop/switch region; other site
359391001673	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
359391001674	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
359391001675	TM-ABC transporter signature motif; other site
359391001676	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
359391001677	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_3; cd06311
359391001678	putative ligand binding site [chemical binding]; other site
359391001679	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
359391001680	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
359391001681	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
359391001682	Oxidoreductase, N-terminal:Oxidoreductase, C-terminal
359391001683	xylose isomerase; Provisional; Region: PRK05474
359391001684	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
359391001685	N- and C-terminal domain interface [polypeptide binding]; other site
359391001686	D-xylulose kinase; Region: XylB; TIGR01312
359391001687	active site
359391001688	MgATP binding site [chemical binding]; other site
359391001689	catalytic site [active]
359391001690	metal binding site [ion binding]; metal-binding site
359391001691	xylulose binding site [chemical binding]; other site
359391001692	homodimer interface [polypeptide binding]; other site
359391001693	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
359391001694	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
359391001695	DNA binding site [nucleotide binding]
359391001696	domain linker motif; other site
359391001697	Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
359391001698	putative ligand binding site [chemical binding]; other site
359391001699	Helix-turn-helix, AraC type
359391001700	transcriptional regulator, AraC family
359391001701	NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090
359391001702	tetrameric interface [polypeptide binding]; other site
359391001703	NAD binding site [chemical binding]; other site
359391001704	catalytic residues [active]
359391001705	choline dehydrogenase; Validated; Region: PRK02106
359391001706	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
359391001707	GMC oxidoreductase; Region: GMC_oxred_N; pfam00732
359391001708	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
359391001709	transcriptional regulator BetI; Validated; Region: PRK00767
359391001710	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
359391001711	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
359391001712	L-asparaginase II [Amino acid transport and metabolism]; Region: AnsA; COG4448
359391001713	transcription elongation factor regulatory protein; Validated; Region: PRK06342
359391001714	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
359391001715	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
359391001716	putative addiction module antidote; Region: doc_partner; TIGR02609
359391001717	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
359391001718	uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837
359391001719	Cl binding site [ion binding]; other site
359391001720	oligomer interface [polypeptide binding]; other site
359391001721	Bacterial regulatory proteins, AsnC family:Bacterial regulatory protein, GntR family
359391001722	transcriptional regulator, gntR family
359391001723	cyanate transport protein CynX
359391001724	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
359391001725	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
359391001726	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
359391001727	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
359391001728	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
359391001729	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
359391001730	motif II; other site
359391001731	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
359391001732	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
359391001733	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
359391001734	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
359391001735	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
359391001736	Predicted transcriptional regulator [Transcription]; Region: COG4957
359391001737	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
359391001738	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
359391001739	DnaA box-binding interface [nucleotide binding]; other site
359391001740	amidase; Validated; Region: PRK05962
359391001741	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
359391001742	Flavin Reductases; Region: FlaRed; cl00801
359391001743	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
359391001744	putative active site [active]
359391001745	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
359391001746	heme pocket [chemical binding]; other site
359391001747	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
359391001748	dimer interface [polypeptide binding]; other site
359391001749	phosphorylation site [posttranslational modification]
359391001750	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
359391001751	ATP binding site [chemical binding]; other site
359391001752	Mg2+ binding site [ion binding]; other site
359391001753	G-X-G motif; other site
359391001754	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
359391001755	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
359391001756	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
359391001757	Uncharacterized conserved protein [Function unknown]; Region: COG5447
359391001758	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330
359391001759	Predicted integral membrane protein [Function unknown]; Region: COG5436
359391001760	Uncharacterized conserved protein [Function unknown]; Region: COG5402
359391001761	Transglycosylase; Region: Transgly; pfam00912
359391001762	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
359391001763	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
359391001764	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
359391001765	Uncharacterized conserved protein [Function unknown]; Region: COG5323
359391001766	Terminase-like family; Region: Terminase_6; pfam03237
359391001767	Phage-related protein [Function unknown]; Region: COG4695
359391001768	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
359391001769	Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653
359391001770	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
359391001771	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
359391001772	oligomerization interface [polypeptide binding]; other site
359391001773	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
359391001774	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
359391001775	Predicted secreted protein [Function unknown]; Region: COG5437
359391001776	Protein of unknown function (DUF3356); Region: DUF3356; pfam11836
359391001777	Phage-related minor tail protein [Function unknown]; Region: COG5281
359391001778	TIGR02217 family protein; Region: chp_TIGR02217
359391001779	conserved hypothetical protein
359391001780	Phospholipase A2
359391001781	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
359391001782	putative phage cell wall peptidase, NlpC/P60 family; Region: phage_NlpC_fam; TIGR02219
359391001783	RNA-binding region RNP-1 (RNA recognition motif)
359391001784	hypothetical
359391001785	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
359391001786	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
359391001787	active site
359391001788	phosphorylation site [posttranslational modification]
359391001789	intermolecular recognition site; other site
359391001790	dimerization interface [polypeptide binding]; other site
359391001791	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
359391001792	DNA binding site [nucleotide binding]
359391001793	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
359391001794	HAMP domain; Region: HAMP; pfam00672
359391001795	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
359391001796	ATP binding site [chemical binding]; other site
359391001797	Mg2+ binding site [ion binding]; other site
359391001798	G-X-G motif; other site
359391001799	Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520
359391001800	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
359391001801	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
359391001802	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
359391001803	binding surface
359391001804	TPR motif; other site
359391001805	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
359391001806	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
359391001807	Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088
359391001808	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
359391001809	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
359391001810	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
359391001811	protein binding site [polypeptide binding]; other site
359391001812	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
359391001813	protein binding site [polypeptide binding]; other site
359391001814	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
359391001815	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
359391001816	active site
359391001817	phosphorylation site [posttranslational modification]
359391001818	intermolecular recognition site; other site
359391001819	dimerization interface [polypeptide binding]; other site
359391001820	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
359391001821	DNA binding site [nucleotide binding]
359391001822	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
359391001823	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
359391001824	dimerization interface [polypeptide binding]; other site
359391001825	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
359391001826	dimer interface [polypeptide binding]; other site
359391001827	phosphorylation site [posttranslational modification]
359391001828	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
359391001829	ATP binding site [chemical binding]; other site
359391001830	Mg2+ binding site [ion binding]; other site
359391001831	G-X-G motif; other site
359391001832	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108
359391001833	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
359391001834	metal binding triad; other site
359391001835	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
359391001836	XPC-binding domain; Region: XPC-binding; pfam09280
359391001837	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
359391001838	metal binding triad; other site
359391001839	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
359391001840	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
359391001841	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; cl15694
359391001842	O-Antigen ligase; Region: Wzy_C; pfam04932
359391001843	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
359391001844	PAS fold; Region: PAS_3; pfam08447
359391001845	putative active site [active]
359391001846	heme pocket [chemical binding]; other site
359391001847	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
359391001848	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
359391001849	dimer interface [polypeptide binding]; other site
359391001850	phosphorylation site [posttranslational modification]
359391001851	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
359391001852	ATP binding site [chemical binding]; other site
359391001853	Mg2+ binding site [ion binding]; other site
359391001854	G-X-G motif; other site
359391001855	aminopeptidase N; Provisional; Region: pepN; PRK14015
359391001856	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
359391001857	active site
359391001858	Zn binding site [ion binding]; other site
359391001859	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
359391001860	EamA-like transporter family; Region: EamA; pfam00892
359391001861	putative MFS family transporter protein; Provisional; Region: PRK03633
359391001862	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
359391001863	putative substrate translocation pore; other site
359391001864	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
359391001865	Fe-S cluster binding site [ion binding]; other site
359391001866	active site
359391001867	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
359391001868	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
359391001869	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
359391001870	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3021
359391001871	putative catalytic site [active]
359391001872	putative metal binding site [ion binding]; other site
359391001873	putative phosphate binding site [ion binding]; other site
359391001874	AMP nucleosidase; Provisional; Region: PRK08292
359391001875	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
359391001876	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
359391001877	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
359391001878	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
359391001879	C-terminal domain interface [polypeptide binding]; other site
359391001880	GSH binding site (G-site) [chemical binding]; other site
359391001881	dimer interface [polypeptide binding]; other site
359391001882	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
359391001883	N-terminal domain interface [polypeptide binding]; other site
359391001884	putative dimer interface [polypeptide binding]; other site
359391001885	active site
359391001886	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4731
359391001887	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
359391001888	Uncharacterized conserved protein [Function unknown]; Region: COG1284
359391001889	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
359391001890	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
359391001891	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
359391001892	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
359391001893	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
359391001894	pyridoxal 5'-phosphate binding site [chemical binding]; other site
359391001895	homodimer interface [polypeptide binding]; other site
359391001896	catalytic residue [active]
359391001897	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
359391001898	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
359391001899	active site
359391001900	DNA binding site [nucleotide binding]
359391001901	Int/Topo IB signature motif; other site
359391001902	Porin subfamily; Region: Porin_2; pfam02530
359391001903	Porin subfamily; Region: Porin_2; pfam02530
359391001904	Uncharacterized conserved protein [Function unknown]; Region: COG3743
359391001905	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
359391001906	dimer interface [polypeptide binding]; other site
359391001907	active site
359391001908	catalytic residue [active]
359391001909	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
359391001910	SmpB-tmRNA interface; other site
359391001911	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
359391001912	Fe-S cluster binding site [ion binding]; other site
359391001913	DNA binding site [nucleotide binding]
359391001914	active site
359391001915	Uncharacterized conserved protein [Function unknown]; Region: COG1432
359391001916	LabA_like proteins; Region: LabA; cd10911
359391001917	putative metal binding site [ion binding]; other site
359391001918	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
359391001919	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
359391001920	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
359391001921	Zn2+ binding site [ion binding]; other site
359391001922	Mg2+ binding site [ion binding]; other site
359391001923	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
359391001924	synthetase active site [active]
359391001925	NTP binding site [chemical binding]; other site
359391001926	metal binding site [ion binding]; metal-binding site
359391001927	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
359391001928	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
359391001929	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
359391001930	active site
359391001931	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
359391001932	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
359391001933	ligand binding site [chemical binding]; other site
359391001934	flexible hinge region; other site
359391001935	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
359391001936	putative switch regulator; other site
359391001937	non-specific DNA interactions [nucleotide binding]; other site
359391001938	DNA binding site [nucleotide binding]
359391001939	sequence specific DNA binding site [nucleotide binding]; other site
359391001940	putative cAMP binding site [chemical binding]; other site
359391001941	coproporphyrinogen III oxidase; Provisional; Region: PRK13347
359391001942	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
359391001943	FeS/SAM binding site; other site
359391001944	HemN C-terminal domain; Region: HemN_C; pfam06969
359391001945	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
359391001946	Major Facilitator Superfamily; Region: MFS_1; pfam07690
359391001947	putative substrate translocation pore; other site
359391001948	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
359391001949	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
359391001950	Helix-turn-helix domain; Region: HTH_18; pfam12833
359391001951	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3216
359391001952	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
359391001953	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
359391001954	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
359391001955	Catalytic site [active]
359391001956	ribonuclease III; Reviewed; Region: PRK12371
359391001957	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
359391001958	dimerization interface [polypeptide binding]; other site
359391001959	active site
359391001960	metal binding site [ion binding]; metal-binding site
359391001961	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
359391001962	dsRNA binding site [nucleotide binding]; other site
359391001963	GTPase Era; Reviewed; Region: era; PRK00089
359391001964	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
359391001965	G1 box; other site
359391001966	GTP/Mg2+ binding site [chemical binding]; other site
359391001967	Switch I region; other site
359391001968	G2 box; other site
359391001969	Switch II region; other site
359391001970	G3 box; other site
359391001971	G4 box; other site
359391001972	G5 box; other site
359391001973	KH domain; Region: KH_2; pfam07650
359391001974	Recombination protein O N terminal; Region: RecO_N; pfam11967
359391001975	DNA repair protein RecO; Region: reco; TIGR00613
359391001976	Recombination protein O C terminal; Region: RecO_C; pfam02565
359391001977	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350
359391001978	Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896
359391001979	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
359391001980	Aminomethyltransferase folate-binding domain; Region: GCV_T; cl01893
359391001981	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
359391001982	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
359391001983	dihydroorotase; Validated; Region: PRK09060
359391001984	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
359391001985	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
359391001986	active site
359391001987	TIGR02301 family protein; Region: TIGR02301
359391001988	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
359391001989	nudix motif; other site
359391001990	Uncharacterized conserved protein [Function unknown]; Region: COG2135
359391001991	Lysine efflux permease [General function prediction only]; Region: COG1279
359391001992	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
359391001993	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
359391001994	active site
359391001995	HIGH motif; other site
359391001996	KMSKS motif; other site
359391001997	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
359391001998	anticodon binding site; other site
359391001999	tRNA binding surface [nucleotide binding]; other site
359391002000	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
359391002001	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
359391002002	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
359391002003	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
359391002004	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
359391002005	active site
359391002006	catalytic residues [active]
359391002007	metal binding site [ion binding]; metal-binding site
359391002008	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
359391002009	Predicted permeases [General function prediction only]; Region: RarD; COG2962
359391002010	Multidrug resistance efflux transporter; Region: EmrE; cl19304
359391002011	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
359391002012	Peptidase family M23; Region: Peptidase_M23; pfam01551
359391002013	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
359391002014	S-adenosylmethionine binding site [chemical binding]; other site
359391002015	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312
359391002016	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
359391002017	SurA N-terminal domain; Region: SurA_N; pfam09312
359391002018	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
359391002019	OstA-like protein; Region: OstA; cl00844
359391002020	OstA-like protein; Region: OstA; cl00844
359391002021	Organic solvent tolerance protein; Region: OstA_C; pfam04453
359391002022	Predicted permeases [General function prediction only]; Region: COG0795
359391002023	Predicted permeases [General function prediction only]; Region: COG0795
359391002024	multifunctional aminopeptidase A; Provisional; Region: PRK00913
359391002025	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
359391002026	interface (dimer of trimers) [polypeptide binding]; other site
359391002027	Substrate-binding/catalytic site; other site
359391002028	Zn-binding sites [ion binding]; other site
359391002029	DNA polymerase III subunit chi; Validated; Region: PRK05728
359391002030	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
359391002031	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
359391002032	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
359391002033	Walker A/P-loop; other site
359391002034	ATP binding site [chemical binding]; other site
359391002035	ABC transporter signature motif; other site
359391002036	Walker B; other site
359391002037	D-loop; other site
359391002038	ABC transporter; Region: ABC_tran_2; pfam12848
359391002039	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
359391002040	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318
359391002041	Nucleoside diphosphate kinase; Region: NDK; pfam00334
359391002042	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
359391002043	active site
359391002044	multimer interface [polypeptide binding]; other site
359391002045	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126
359391002046	Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187
359391002047	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
359391002048	MoaE homodimer interface [polypeptide binding]; other site
359391002049	MoaD interaction [polypeptide binding]; other site
359391002050	active site residues [active]
359391002051	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
359391002052	MoaE interaction surface [polypeptide binding]; other site
359391002053	MoeB interaction surface [polypeptide binding]; other site
359391002054	thiocarboxylated glycine; other site
359391002055	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
359391002056	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
359391002057	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
359391002058	GIY-YIG motif/motif A; other site
359391002059	active site
359391002060	catalytic site [active]
359391002061	putative DNA binding site [nucleotide binding]; other site
359391002062	metal binding site [ion binding]; metal-binding site
359391002063	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
359391002064	Helix-hairpin-helix domain; Region: HHH_5; pfam14520
359391002065	short chain dehydrogenase; Provisional; Region: PRK09134
359391002066	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
359391002067	NAD(P) binding site [chemical binding]; other site
359391002068	active site
359391002069	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
359391002070	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
359391002071	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
359391002072	putative C-terminal domain interface [polypeptide binding]; other site
359391002073	putative GSH binding site (G-site) [chemical binding]; other site
359391002074	putative dimer interface [polypeptide binding]; other site
359391002075	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
359391002076	dimer interface [polypeptide binding]; other site
359391002077	N-terminal domain interface [polypeptide binding]; other site
359391002078	putative substrate binding pocket (H-site) [chemical binding]; other site
359391002079	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
359391002080	B1 nucleotide binding pocket [chemical binding]; other site
359391002081	B2 nucleotide binding pocket [chemical binding]; other site
359391002082	CAS motifs; other site
359391002083	active site
359391002084	Bacteriophage capsid protein [General function prediction only]; Region: COG5511
359391002085	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
359391002086	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
359391002087	EamA-like transporter family; Region: EamA; pfam00892
359391002088	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
359391002089	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
359391002090	putative [4Fe-4S] binding site [ion binding]; other site
359391002091	putative molybdopterin cofactor binding site [chemical binding]; other site
359391002092	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
359391002093	putative molybdopterin cofactor binding site; other site
359391002094	Protein of unknown function (DUF992); Region: DUF992; pfam06186
359391002095	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
359391002096	active site
359391002097	substrate binding site [chemical binding]; other site
359391002098	cosubstrate binding site; other site
359391002099	catalytic site [active]
359391002100	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
359391002101	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
359391002102	dimerization interface [polypeptide binding]; other site
359391002103	putative ATP binding site [chemical binding]; other site
359391002104	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
359391002105	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
359391002106	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
359391002107	Walker A motif; other site
359391002108	ATP binding site [chemical binding]; other site
359391002109	Walker B motif; other site
359391002110	arginine finger; other site
359391002111	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; cl19912
359391002112	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
359391002113	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
359391002114	NAD(P) binding site [chemical binding]; other site
359391002115	active site
359391002116	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951
359391002117	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
359391002118	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
359391002119	putative NAD(P) binding site [chemical binding]; other site
359391002120	putative active site [active]
359391002121	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
359391002122	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
359391002123	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
359391002124	active site
359391002125	catalytic site [active]
359391002126	substrate binding site [chemical binding]; other site
359391002127	Archaeal adenylate kinase [Nucleotide transport and metabolism]; Region: AdkA; cl17890
359391002128	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
359391002129	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
359391002130	non-specific DNA binding site [nucleotide binding]; other site
359391002131	salt bridge; other site
359391002132	sequence-specific DNA binding site [nucleotide binding]; other site
359391002133	Uncharacterized conserved protein [Function unknown]; Region: COG4933
359391002134	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
359391002135	Integrase core domain; Region: rve; pfam00665
359391002136	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
359391002137	ATP/GTP-binding site motif A (P-loop)
359391002138	transposition protein, putative
359391002139	TniQ; Region: TniQ; pfam06527
359391002140	Restriction endonuclease; Region: Mrr_cat; cl19295
359391002141	Domain of unknown function (DUF955); Region: DUF955; pfam06114
359391002142	ApeA
359391002143	conserved hypothetical protein
359391002144	conserved hypothetical protein
359391002145	Uncharacterized protein containing a TIR (Toll-Interleukin 1-resistance) domain [Function unknown]; Region: COG4916
359391002146	TIR domain; Region: TIR_2; pfam13676
359391002147	Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991
359391002148	Bacterial SH3 domain; Region: SH3_3; pfam08239
359391002149	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
359391002150	homodimer interface [polypeptide binding]; other site
359391002151	substrate-cofactor binding pocket; other site
359391002152	pyridoxal 5'-phosphate binding site [chemical binding]; other site
359391002153	catalytic residue [active]
359391002154	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
359391002155	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
359391002156	active site
359391002157	amino acid ABC transporter, periplasmic amino acid-binding protein KO: K02030 polar amino acid transport system substrate-bi...
359391002158	Solute-binding protein/glutamate receptor:Bacterial extracellular solute-binding protein, family 3
359391002159	general L-amino acid transport system permease protein AapQ KO: K02029 polar amino acid transport system permease proetin
359391002160	hypothetical
359391002161	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
359391002162	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391002163	dimer interface [polypeptide binding]; other site
359391002164	conserved gate region; other site
359391002165	putative PBP binding loops; other site
359391002166	ABC-ATPase subunit interface; other site
359391002167	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
359391002168	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
359391002169	Walker A/P-loop; other site
359391002170	ATP binding site [chemical binding]; other site
359391002171	Q-loop/lid; other site
359391002172	ABC transporter signature motif; other site
359391002173	Walker B; other site
359391002174	D-loop; other site
359391002175	H-loop/switch region; other site
359391002176	salicylate hydroxylase; Provisional; Region: PRK06475
359391002177	salicylate hydroxylase; Provisional; Region: PRK08163
359391002178	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391
359391002179	polyphosphate kinase; Provisional; Region: PRK05443
359391002180	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
359391002181	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
359391002182	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
359391002183	putative domain interface [polypeptide binding]; other site
359391002184	putative active site [active]
359391002185	catalytic site [active]
359391002186	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
359391002187	putative domain interface [polypeptide binding]; other site
359391002188	putative active site [active]
359391002189	catalytic site [active]
359391002190	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
359391002191	exopolyphosphatase; Region: exo_poly_only; TIGR03706
359391002192	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
359391002193	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
359391002194	catalytic site [active]
359391002195	putative active site [active]
359391002196	putative substrate binding site [chemical binding]; other site
359391002197	HRDC domain; Region: HRDC; pfam00570
359391002198	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
359391002199	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
359391002200	dimer interface [polypeptide binding]; other site
359391002201	anticodon binding site; other site
359391002202	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
359391002203	homodimer interface [polypeptide binding]; other site
359391002204	motif 1; other site
359391002205	active site
359391002206	motif 2; other site
359391002207	GAD domain; Region: GAD; pfam02938
359391002208	motif 3; other site
359391002209	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
359391002210	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
359391002211	CAP-like domain; other site
359391002212	active site
359391002213	primary dimer interface [polypeptide binding]; other site
359391002214	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
359391002215	Putative arginyl-tRNA:protein arginylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG2935
359391002216	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
359391002217	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
359391002218	Predicted membrane protein/domain [Function unknown]; Region: COG1714
359391002219	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
359391002220	dimer interface [polypeptide binding]; other site
359391002221	allosteric magnesium binding site [ion binding]; other site
359391002222	active site
359391002223	aspartate-rich active site metal binding site; other site
359391002224	Schiff base residues; other site
359391002225	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
359391002226	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
359391002227	substrate binding site [chemical binding]; other site
359391002228	oxyanion hole (OAH) forming residues; other site
359391002229	trimer interface [polypeptide binding]; other site
359391002230	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
359391002231	Transcriptional regulators [Transcription]; Region: MarR; COG1846
359391002232	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
359391002233	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
359391002234	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
359391002235	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
359391002236	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
359391002237	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
359391002238	dimer interface [polypeptide binding]; other site
359391002239	active site
359391002240	glycine-pyridoxal phosphate binding site [chemical binding]; other site
359391002241	folate binding site [chemical binding]; other site
359391002242	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
359391002243	ATP cone domain; Region: ATP-cone; pfam03477
359391002244	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
359391002245	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
359391002246	catalytic motif [active]
359391002247	Zn binding site [ion binding]; other site
359391002248	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
359391002249	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
359391002250	Lumazine binding domain; Region: Lum_binding; pfam00677
359391002251	Lumazine binding domain; Region: Lum_binding; pfam00677
359391002252	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
359391002253	homopentamer interface [polypeptide binding]; other site
359391002254	active site
359391002255	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
359391002256	putative RNA binding site [nucleotide binding]; other site
359391002257	Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; COG3808
359391002258	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
359391002259	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
359391002260	Uncharacterized conserved protein [Function unknown]; Region: COG5452
359391002261	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
359391002262	putative phosphate acyltransferase; Provisional; Region: PRK05331
359391002263	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
359391002264	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
359391002265	dimer interface [polypeptide binding]; other site
359391002266	active site
359391002267	CoA binding pocket [chemical binding]; other site
359391002268	Alpha subunit of integration host factor (IHFA); Region: IHF_A; cd13835
359391002269	DNA binding site [nucleotide binding]
359391002270	dimer interface [polypeptide binding]; other site
359391002271	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
359391002272	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
359391002273	DNA binding residues [nucleotide binding]
359391002274	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
359391002275	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
359391002276	CoA-binding domain; Region: CoA_binding_3; pfam13727
359391002277	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
359391002278	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
359391002279	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
359391002280	SLBB domain; Region: SLBB; pfam10531
359391002281	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
359391002282	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
359391002283	Protein of unknown function (DUF2842); Region: DUF2842; pfam11003
359391002284	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
359391002285	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
359391002286	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
359391002287	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
359391002288	oligomer interface [polypeptide binding]; other site
359391002289	putative active site [active]
359391002290	Mn binding site [ion binding]; other site
359391002291	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
359391002292	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
359391002293	23S rRNA interface [nucleotide binding]; other site
359391002294	L3 interface [polypeptide binding]; other site
359391002295	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
359391002296	CoenzymeA binding site [chemical binding]; other site
359391002297	subunit interaction site [polypeptide binding]; other site
359391002298	PHB binding site; other site
359391002299	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
359391002300	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
359391002301	homodimer interface [polypeptide binding]; other site
359391002302	substrate-cofactor binding pocket; other site
359391002303	pyridoxal 5'-phosphate binding site [chemical binding]; other site
359391002304	catalytic residue [active]
359391002306	conserved hypothetical protein
359391002307	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
359391002308	NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377
359391002309	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
359391002310	NADH dehydrogenase subunit D; Validated; Region: PRK06075
359391002311	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
359391002312	NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905
359391002313	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
359391002314	putative dimer interface [polypeptide binding]; other site
359391002315	[2Fe-2S] cluster binding site [ion binding]; other site
359391002316	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
359391002317	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
359391002318	SLBB domain; Region: SLBB; pfam10531
359391002319	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
359391002320	NADH dehydrogenase subunit G; Validated; Region: PRK09130
359391002321	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
359391002322	catalytic loop [active]
359391002323	iron binding site [ion binding]; other site
359391002324	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
359391002325	MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773
359391002326	Domain of unknown function (DUF1982); Region: DUF1982; pfam09326
359391002327	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
359391002328	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
359391002329	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
359391002330	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
359391002331	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
359391002332	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
359391002333	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
359391002334	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
359391002335	NADH dehydrogenase subunit 5 C-terminus; Region: NADH5_C; pfam06455
359391002336	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
359391002337	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
359391002338	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
359391002339	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
359391002340	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
359391002341	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
359391002342	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
359391002343	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
359391002344	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
359391002345	RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521
359391002346	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
359391002347	dimer interface [polypeptide binding]; other site
359391002348	substrate binding site [chemical binding]; other site
359391002349	metal binding site [ion binding]; metal-binding site
359391002350	Predicted secreted protein [Function unknown]; Region: COG5454
359391002351	prolyl-tRNA synthetase; Provisional; Region: PRK12325
359391002352	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
359391002353	dimer interface [polypeptide binding]; other site
359391002354	motif 1; other site
359391002355	active site
359391002356	motif 2; other site
359391002357	motif 3; other site
359391002358	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
359391002359	anticodon binding site; other site
359391002360	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
359391002361	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
359391002362	FtsX-like permease family; Region: FtsX; pfam02687
359391002363	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
359391002364	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
359391002365	Walker A/P-loop; other site
359391002366	ATP binding site [chemical binding]; other site
359391002367	Q-loop/lid; other site
359391002368	ABC transporter signature motif; other site
359391002369	Walker B; other site
359391002370	D-loop; other site
359391002371	H-loop/switch region; other site
359391002372	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
359391002373	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
359391002374	putative active site [active]
359391002375	putative PHP Thumb interface [polypeptide binding]; other site
359391002376	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
359391002377	Helix-hairpin-helix motif; Region: HHH_6; pfam14579
359391002378	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
359391002379	generic binding surface II; other site
359391002380	generic binding surface I; other site
359391002381	Protein of unknwon function (DUF3008); Region: DUF3008; pfam11450
359391002382	conserved hypothetical protein
359391002383	conserved hypothetical protein
359391002384	conserved hypothetical protein
359391002385	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
359391002386	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
359391002387	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
359391002388	RNA binding surface [nucleotide binding]; other site
359391002389	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
359391002390	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
359391002391	Ligand Binding Site [chemical binding]; other site
359391002392	PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517
359391002393	active site
359391002394	putative lithium-binding site [ion binding]; other site
359391002395	substrate binding site [chemical binding]; other site
359391002396	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
359391002397	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
359391002398	putative substrate translocation pore; other site
359391002399	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
359391002400	putative GSH binding site [chemical binding]; other site
359391002401	catalytic residues [active]
359391002402	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
359391002403	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
359391002404	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
359391002405	dimerization interface [polypeptide binding]; other site
359391002406	ATP binding site [chemical binding]; other site
359391002407	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
359391002408	dimerization interface [polypeptide binding]; other site
359391002409	ATP binding site [chemical binding]; other site
359391002410	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
359391002411	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
359391002412	C-terminal domain interface [polypeptide binding]; other site
359391002413	GSH binding site (G-site) [chemical binding]; other site
359391002414	dimer interface [polypeptide binding]; other site
359391002415	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
359391002416	N-terminal domain interface [polypeptide binding]; other site
359391002417	dimer interface [polypeptide binding]; other site
359391002418	substrate binding pocket (H-site) [chemical binding]; other site
359391002419	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
359391002420	putative active site [active]
359391002421	catalytic triad [active]
359391002422	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
359391002423	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
359391002424	ATP binding site [chemical binding]; other site
359391002425	active site
359391002426	substrate binding site [chemical binding]; other site
359391002427	Uncharacterized conserved protein [Function unknown]; Region: COG5467
359391002428	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
359391002429	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
359391002430	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
359391002431	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
359391002432	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
359391002433	putative metal binding site [ion binding]; other site
359391002434	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
359391002435	active site
359391002436	adenylosuccinate lyase; Provisional; Region: PRK07492
359391002437	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
359391002438	tetramer interface [polypeptide binding]; other site
359391002439	active site
359391002440	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
359391002441	substrate binding site [chemical binding]; other site
359391002442	hexamer interface [polypeptide binding]; other site
359391002443	metal binding site [ion binding]; metal-binding site
359391002444	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
359391002445	putative acyl-acceptor binding pocket; other site
359391002446	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
359391002447	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266
359391002448	putative NAD(P) binding site [chemical binding]; other site
359391002449	structural Zn binding site [ion binding]; other site
359391002450	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501
359391002451	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
359391002452	dimer interface [polypeptide binding]; other site
359391002453	active site
359391002454	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519
359391002455	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
359391002456	active site
359391002457	acyl carrier protein; Provisional; Region: PRK06508
359391002458	Lysozyme family protein [General function prediction only]; Region: zliS; COG3926
359391002459	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
359391002460	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
359391002461	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
359391002462	active site
359391002463	catalytic residues [active]
359391002464	Carbohydrate kinase, PfkB
359391002465	putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223
359391002466	Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454
359391002467	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
359391002468	PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306
359391002469	active site
359391002470	putative phosphatase; Provisional; Region: PRK11587
359391002471	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
359391002472	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
359391002473	active site
359391002474	motif I; other site
359391002475	motif II; other site
359391002476	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
359391002477	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
359391002478	substrate binding pocket [chemical binding]; other site
359391002479	membrane-bound complex binding site; other site
359391002480	hinge residues; other site
359391002481	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
359391002482	Dihydrouridine synthase (Dus); Region: Dus; pfam01207
359391002483	FMN binding site [chemical binding]; other site
359391002484	active site
359391002485	catalytic residues [active]
359391002486	substrate binding site [chemical binding]; other site
359391002487	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
359391002488	catalytic motif [active]
359391002489	Catalytic residue [active]
359391002490	Predicted Fe-S protein [General function prediction only]; Region: COG3313
359391002491	cobalamin synthase; Reviewed; Region: cobS; PRK00235
359391002492	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
359391002493	putative dimer interface [polypeptide binding]; other site
359391002494	active site pocket [active]
359391002495	putative cataytic base [active]
359391002496	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
359391002497	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
359391002498	putative DNA binding site [nucleotide binding]; other site
359391002499	putative Zn2+ binding site [ion binding]; other site
359391002500	AsnC family; Region: AsnC_trans_reg; pfam01037
359391002501	conserved hypothetical protein
359391002502	Staphylococcus nuclease (SNase-like)
359391002503	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
359391002504	Sel1-like repeats; Region: SEL1; smart00671
359391002505	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
359391002506	putative catalytic site [active]
359391002507	putative phosphate binding site [ion binding]; other site
359391002508	active site
359391002509	metal binding site A [ion binding]; metal-binding site
359391002510	DNA binding site [nucleotide binding]
359391002511	putative AP binding site [nucleotide binding]; other site
359391002512	putative metal binding site B [ion binding]; other site
359391002513	Protein of unknown function (DUF533); Region: DUF533; pfam04391
359391002514	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
359391002515	putative metal binding site [ion binding]; other site
359391002516	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
359391002517	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
359391002518	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
359391002519	Zn2+ binding site [ion binding]; other site
359391002520	Mg2+ binding site [ion binding]; other site
359391002521	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
359391002522	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
359391002523	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
359391002524	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
359391002525	active site
359391002526	HIGH motif; other site
359391002527	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
359391002528	KMSK motif region; other site
359391002529	tRNA binding surface [nucleotide binding]; other site
359391002530	DALR anticodon binding domain; Region: DALR_1; smart00836
359391002531	anticodon binding site; other site
359391002532	rare lipoprotein A; Provisional; Region: PRK10672
359391002533	Sporulation related domain; Region: SPOR; pfam05036
359391002534	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
359391002535	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
359391002536	Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386
359391002537	twin arginine translocase protein A; Provisional; Region: tatA; PRK00720
359391002538	sec-independent translocase; Provisional; Region: PRK00708
359391002539	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
359391002540	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
359391002541	seryl-tRNA synthetase; Provisional; Region: PRK05431
359391002542	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
359391002543	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
359391002544	dimer interface [polypeptide binding]; other site
359391002545	active site
359391002546	motif 1; other site
359391002547	motif 2; other site
359391002548	motif 3; other site
359391002549	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
359391002550	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
359391002551	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
359391002552	S-adenosylmethionine binding site [chemical binding]; other site
359391002553	hypothetical protein; Reviewed; Region: PRK11901
359391002554	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
359391002555	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
359391002556	Peptidase family M23; Region: Peptidase_M23; pfam01551
359391002557	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
359391002558	Walker A motif; other site
359391002559	ATP binding site [chemical binding]; other site
359391002560	Walker B motif; other site
359391002561	Preprotein translocase subunit YajC [Intracellular trafficking and secretion]; Region: YajC; COG1862
359391002562	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13023
359391002563	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
359391002564	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
359391002565	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
359391002566	Protein export membrane protein; Region: SecD_SecF; pfam02355
359391002567	Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248
359391002568	Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562
359391002569	substrate binding pocket [chemical binding]; other site
359391002570	substrate-Mg2+ binding site; other site
359391002571	aspartate-rich region 1; other site
359391002572	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
359391002573	Glucose inhibited division protein A; Region: GIDA; pfam01134
359391002574	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
359391002575	Predicted membrane protein [Function unknown]; Region: COG4872
359391002576	Uncharacterized membrane-anchored protein [Function unknown]; Region: COG4929
359391002577	trigger factor; Provisional; Region: tig; PRK01490
359391002578	Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697
359391002579	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
359391002580	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
359391002581	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
359391002582	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
359391002583	GatB domain; Region: GatB_Yqey; smart00845
359391002584	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
359391002585	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
359391002586	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
359391002587	Coenzyme A binding pocket [chemical binding]; other site
359391002588	NADH dehydrogenase; Validated; Region: PRK08183
359391002589	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4765
359391002590	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
359391002591	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
359391002592	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
359391002593	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
359391002594	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
359391002595	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
359391002596	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
359391002597	carboxyltransferase (CT) interaction site; other site
359391002598	biotinylation site [posttranslational modification]; other site
359391002599	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
359391002600	trimer interface [polypeptide binding]; other site
359391002601	active site
359391002602	dimer interface [polypeptide binding]; other site
359391002603	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
359391002604	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
359391002605	catalytic residues [active]
359391002606	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
359391002607	Peptidase family M48; Region: Peptidase_M48; cl12018
359391002608	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
359391002609	TPR motif; other site
359391002610	binding surface
359391002611	aspartate aminotransferase; Provisional; Region: PRK05764
359391002612	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
359391002613	pyridoxal 5'-phosphate binding site [chemical binding]; other site
359391002614	homodimer interface [polypeptide binding]; other site
359391002615	catalytic residue [active]
359391002616	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
359391002617	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
359391002618	homodimer interface [polypeptide binding]; other site
359391002619	oligonucleotide binding site [chemical binding]; other site
359391002620	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
359391002621	AMIN domain; Region: AMIN; pfam11741
359391002622	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
359391002623	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
359391002624	active site
359391002625	metal binding site [ion binding]; metal-binding site
359391002626	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
359391002627	Transglycosylase; Region: Transgly; pfam00912
359391002628	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
359391002629	peptide chain release factor 2; Provisional; Region: PRK07342
359391002630	This domain is found in peptide chain release factors; Region: PCRF; smart00937
359391002631	RF-1 domain; Region: RF-1; pfam00472
359391002632	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
359391002633	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
359391002634	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
359391002635	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
359391002636	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
359391002637	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
359391002638	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
359391002639	dinuclear metal binding motif [ion binding]; other site
359391002640	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
359391002641	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
359391002642	catalytic triad [active]
359391002643	Protein of unknown function; Region: DUF3971; pfam13116
359391002644	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
359391002645	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
359391002646	active site
359391002647	HIGH motif; other site
359391002648	dimer interface [polypeptide binding]; other site
359391002649	KMSKS motif; other site
359391002650	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
359391002651	RNA binding surface [nucleotide binding]; other site
359391002652	Predicted molecular chaperone distantly related to HSP70-fold metalloproteases [Posttranslational modification, protein turnover, chaperones]; Region: COG2377
359391002653	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
359391002654	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
359391002655	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
359391002656	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
359391002657	catalytic residue [active]
359391002658	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
359391002659	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
359391002660	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
359391002661	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
359391002662	Walker A/P-loop; other site
359391002663	ATP binding site [chemical binding]; other site
359391002664	Q-loop/lid; other site
359391002665	ABC transporter signature motif; other site
359391002666	Walker B; other site
359391002667	D-loop; other site
359391002668	H-loop/switch region; other site
359391002669	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
359391002670	FeS assembly protein SufD; Region: sufD; TIGR01981
359391002671	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
359391002672	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
359391002673	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
359391002674	catalytic residue [active]
359391002675	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
359391002676	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
359391002677	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
359391002678	active site
359391002679	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
359391002680	inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761
359391002681	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
359391002682	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
359391002683	ATP binding site [chemical binding]; other site
359391002684	Mg++ binding site [ion binding]; other site
359391002685	motif III; other site
359391002686	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
359391002687	nucleotide binding region [chemical binding]; other site
359391002688	ATP-binding site [chemical binding]; other site
359391002689	FeS assembly scaffold SufA; Region: sufA_proteo; TIGR01997
359391002690	conserved hypothetical protein
359391002691	conserved hypothetical protein
359391002692	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
359391002693	metal-binding site [ion binding]
359391002694	Methyltransferase domain; Region: Methyltransf_31; pfam13847
359391002695	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
359391002696	S-adenosylmethionine binding site [chemical binding]; other site
359391002697	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
359391002698	Outer membrane efflux protein; Region: OEP; pfam02321
359391002699	Outer membrane efflux protein; Region: OEP; pfam02321
359391002700	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3827
359391002701	Protein of unknown function (DUF2497); Region: DUF2497; pfam10691
359391002702	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
359391002703	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
359391002704	active site
359391002705	HIGH motif; other site
359391002706	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
359391002707	KMSKS motif; other site
359391002708	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
359391002709	tRNA binding surface [nucleotide binding]; other site
359391002710	anticodon binding site; other site
359391002711	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
359391002712	Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067
359391002713	possible oxidoreductase, putative
359391002714	3-hydroxyisobutyrate dehydrogenase:TrkA potassium uptake protein:6-phosphogluconate dehydrogenase, NAD binding domain:6-phosp...
359391002715	Solute-binding protein/glutamate receptor:Bacterial extracellular solute-binding protein, family 3
359391002716	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
359391002717	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
359391002718	GTP binding site; other site
359391002719	molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361
359391002720	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
359391002721	FeS/SAM binding site; other site
359391002722	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
359391002723	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
359391002724	Flavoprotein monooxygenase:Aromatic-ring hydroxylase
359391002725	hypothetical
359391002726	fumarate hydratase; Provisional; Region: PRK15389
359391002727	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
359391002728	Fumarase C-terminus; Region: Fumerase_C; pfam05683
359391002729	SPTR top hit: 'Q8G0X0 Hypothetical protein. Brucella suis., evalue=0.0, 99% identity hit'; KEGG top hit: 'bms:BR0962 category=Unassigned, evalue=0.0, 99.193548% identity hit'; COGs: 'evalue=2e-79 score=289 category=S group=COG2989 Uncharacterized protein conserved in bacteria';similar to Uncharacterized protein conserved in bacteria
359391002730	conserved hypothetical protein
359391002731	Predicted membrane protein [Function unknown]; Region: COG2261
359391002732	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
359391002733	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
359391002734	active site
359391002735	Int/Topo IB signature motif; other site
359391002736	catalytic residues [active]
359391002737	DNA binding site [nucleotide binding]
359391002738	conserved hypothetical protein
359391002739	conserved hypothetical protein
359391002740	conserved hypothetical protein
359391002741	outer membrane protein, putative
359391002742	outer membrane protein, putative
359391002743	Domain of unknown function (DUF1508); Region: DUF1508; cl01356
359391002744	Domain of unknown function (DUF4415); Region: DUF4415; cl01401
359391002745	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929
359391002746	Queuine/other tRNA-ribosyltransferase
359391002747	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
359391002748	conserved hypothetical protein
359391002749	conserved hypothetical protein
359391002750	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
359391002751	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
359391002752	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
359391002753	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
359391002754	Lysozyme family protein [General function prediction only]; Region: zliS; COG3926
359391002755	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
359391002756	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
359391002757	conserved hypothetical protein
359391002758	conserved hypothetical protein
359391002759	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
359391002760	catalytic residues [active]
359391002761	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
359391002762	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
359391002763	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
359391002764	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191
359391002765	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
359391002766	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
359391002767	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
359391002768	TMP-binding site; other site
359391002769	ATP-binding site [chemical binding]; other site
359391002770	DNA polymerase III subunit delta'; Validated; Region: PRK09112
359391002771	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
359391002772	Walker A motif; other site
359391002773	ATP binding site [chemical binding]; other site
359391002774	Walker B motif; other site
359391002775	arginine finger; other site
359391002776	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
359391002777	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
359391002778	active site
359391002779	HIGH motif; other site
359391002780	KMSKS motif; other site
359391002781	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
359391002782	tRNA binding surface [nucleotide binding]; other site
359391002783	anticodon binding site; other site
359391002784	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
359391002785	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
359391002786	active site
359391002787	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
359391002788	cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657
359391002789	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
359391002790	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
359391002791	Walker A/P-loop; other site
359391002792	ATP binding site [chemical binding]; other site
359391002793	Q-loop/lid; other site
359391002794	ABC transporter signature motif; other site
359391002795	Walker B; other site
359391002796	D-loop; other site
359391002797	H-loop/switch region; other site
359391002798	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
359391002799	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
359391002800	active site
359391002801	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
359391002802	EamA-like transporter family; Region: EamA; pfam00892
359391002803	EamA-like transporter family; Region: EamA; pfam00892
359391002804	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
359391002805	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
359391002806	active site
359391002807	motif I; other site
359391002808	motif II; other site
359391002809	Chaperone required for the assembly of the mitochondrial F1-ATPase [Posttranslational modification, protein turnover, chaperones]; Region: COG5387
359391002810	glutamine synthetase; Provisional; Region: glnA; PRK09469
359391002811	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
359391002812	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
359391002813	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
359391002814	Uncharacterized conserved protein [Function unknown]; Region: COG0062
359391002815	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
359391002816	putative substrate binding site [chemical binding]; other site
359391002817	putative ATP binding site [chemical binding]; other site
359391002818	phosphoglycolate phosphatase; Provisional; Region: PRK13222
359391002819	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
359391002820	active site
359391002821	motif I; other site
359391002822	motif II; other site
359391002823	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3184
359391002824	glutathione reductase; Validated; Region: PRK06116
359391002825	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
359391002826	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
359391002827	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
359391002828	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
359391002829	Integral membrane diacylglycerol kinase; Region: DAGK_IM; cd14264
359391002830	putative active site [active]
359391002831	trimer interface [polypeptide binding]; other site
359391002832	putative active site [active]
359391002833	Zn binding site [ion binding]; other site
359391002834	NAD synthetase; Provisional; Region: PRK13981
359391002835	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
359391002836	multimer interface [polypeptide binding]; other site
359391002837	active site
359391002838	catalytic triad [active]
359391002839	protein interface 1 [polypeptide binding]; other site
359391002840	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
359391002841	homodimer interface [polypeptide binding]; other site
359391002842	NAD binding pocket [chemical binding]; other site
359391002843	ATP binding pocket [chemical binding]; other site
359391002844	Mg binding site [ion binding]; other site
359391002845	active-site loop [active]
359391002846	glutamyl-tRNA synthetase; Provisional; Region: PRK12558
359391002847	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
359391002848	active site
359391002849	HIGH motif; other site
359391002850	KMSKS motif; other site
359391002851	Baculovirus 33KDa late protein (PP31); Region: Baculo_PP31; pfam05311
359391002852	malic enzyme; Reviewed; Region: PRK12862
359391002853	Malic enzyme, N-terminal domain; Region: malic; pfam00390
359391002854	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
359391002855	putative NAD(P) binding site [chemical binding]; other site
359391002856	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
359391002857	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
359391002858	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
359391002859	active site
359391002860	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
359391002861	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
359391002862	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
359391002863	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
359391002864	Walker A/P-loop; other site
359391002865	ATP binding site [chemical binding]; other site
359391002866	Q-loop/lid; other site
359391002867	ABC transporter signature motif; other site
359391002868	Walker B; other site
359391002869	D-loop; other site
359391002870	H-loop/switch region; other site
359391002871	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
359391002872	mce related protein; Region: MCE; pfam02470
359391002873	ABC-type uncharacterized transport system, auxiliary component [General function prediction only]; Region: COG3218
359391002874	chromosome segregation protein; Provisional; Region: PRK02224
359391002875	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
359391002876	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
359391002877	catalytic loop [active]
359391002878	iron binding site [ion binding]; other site
359391002879	thioredoxin reductase
359391002880	thioredoxin reductase
359391002881	Predicted secreted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5661
359391002882	Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294
359391002883	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
359391002884	substrate binding pocket [chemical binding]; other site
359391002885	dimer interface [polypeptide binding]; other site
359391002886	inhibitor binding site; inhibition site
359391002887	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
359391002888	homooctamer interface [polypeptide binding]; other site
359391002889	active site
359391002890	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
359391002891	catalytic center binding site [active]
359391002892	ATP binding site [chemical binding]; other site
359391002893	Predicted membrane protein [Function unknown]; Region: COG3768
359391002894	hypothetical protein; Provisional; Region: PRK05415
359391002895	YcjX-like family, DUF463; Region: DUF463; cl01193
359391002896	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
359391002897	catalytic core [active]
359391002898	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
359391002899	flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500
359391002900	PAS domain:ATP-binding region, ATPase-like:Histidine kinase A, N-terminal:Bacterial sensor protein, C-terminal:Histidine kinase
359391002901	Predicted flavoproteins [General function prediction only]; Region: COG2081
359391002902	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
359391002903	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
359391002904	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
359391002905	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
359391002906	Mechanosensitive ion channel; Region: MS_channel; pfam00924
359391002907	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562
359391002908	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
359391002909	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
359391002910	active site
359391002911	dimer interface [polypeptide binding]; other site
359391002912	effector binding site; other site
359391002913	TSCPD domain; Region: TSCPD; pfam12637
359391002914	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666
359391002915	nudix motif; other site
359391002916	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
359391002917	active site
359391002918	Universal stress protein family; Region: Usp; pfam00582
359391002919	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
359391002920	Ligand Binding Site [chemical binding]; other site
359391002921	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
359391002922	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
359391002923	putative MPT binding site; other site
359391002924	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
359391002925	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
359391002926	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
359391002927	ATP binding site [chemical binding]; other site
359391002928	Mg++ binding site [ion binding]; other site
359391002929	motif III; other site
359391002930	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
359391002931	nucleotide binding region [chemical binding]; other site
359391002932	ATP-binding site [chemical binding]; other site
359391002933	cysteine synthase; Region: PLN02565
359391002934	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
359391002935	dimer interface [polypeptide binding]; other site
359391002936	pyridoxal 5'-phosphate binding site [chemical binding]; other site
359391002937	catalytic residue [active]
359391002938	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
359391002939	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
359391002940	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
359391002941	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
359391002942	active site residue [active]
359391002943	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
359391002944	active site residue [active]
359391002945	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
359391002946	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
359391002947	Coenzyme A binding pocket [chemical binding]; other site
359391002948	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
359391002949	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
359391002950	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
359391002951	drug resistance transporter, EmrB/QacA family
359391002952	Tetracycline resistance protein TetB:Tetracycline resistance protein:Major facilitator superfamily (MFS)
359391002953	HlyD family secretion protein
359391002954	Serine proteases, subtilase family:Cytochrome c heme-binding site
359391002955	proline dipeptidase
359391002956	alcohol dehydrogenase, zinc-containing
359391002957	Zinc-containing alcohol dehydrogenase superfamily:Zinc-containing alcohol dehydrogenase
359391002958	Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976
359391002959	Tetratricopeptide repeat; Region: TPR_1; pfam00515
359391002960	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
359391002961	S-adenosylmethionine binding site [chemical binding]; other site
359391002962	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
359391002963	UDP-glucose 4-epimerase; Region: PLN02240
359391002964	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
359391002965	NAD binding site [chemical binding]; other site
359391002966	homodimer interface [polypeptide binding]; other site
359391002967	active site
359391002968	substrate binding site [chemical binding]; other site
359391002969	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
359391002970	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
359391002971	homodimer interface [polypeptide binding]; other site
359391002972	metal binding site [ion binding]; metal-binding site
359391002973	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
359391002974	homodimer interface [polypeptide binding]; other site
359391002975	active site
359391002976	putative chemical substrate binding site [chemical binding]; other site
359391002977	metal binding site [ion binding]; metal-binding site
359391002978	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
359391002979	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
359391002980	putative FMN binding site [chemical binding]; other site
359391002981	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
359391002982	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
359391002983	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
359391002984	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
359391002985	active site
359391002986	dimer interface [polypeptide binding]; other site
359391002987	motif 1; other site
359391002988	motif 2; other site
359391002989	motif 3; other site
359391002990	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
359391002991	anticodon binding site; other site
359391002992	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
359391002993	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191
359391002994	Sporulation related domain; Region: SPOR; pfam05036
359391002995	hypothetical protein; Validated; Region: PRK00041
359391002996	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
359391002997	trimerization site [polypeptide binding]; other site
359391002998	active site
359391002999	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
359391003000	active site
359391003001	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
359391003002	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
359391003003	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
359391003004	active site
359391003005	nucleophile elbow; other site
359391003006	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
359391003007	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
359391003008	active site
359391003009	DNA binding site [nucleotide binding]
359391003010	Int/Topo IB signature motif; other site
359391003011	conserved hypothetical protein
359391003012	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
359391003013	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
359391003014	catalytic residues [active]
359391003015	catalytic nucleophile [active]
359391003016	Presynaptic Site I dimer interface [polypeptide binding]; other site
359391003017	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
359391003018	Synaptic Flat tetramer interface [polypeptide binding]; other site
359391003019	Synaptic Site I dimer interface [polypeptide binding]; other site
359391003020	DNA binding site [nucleotide binding]
359391003021	Prophage antirepressor [Transcription]; Region: COG3617
359391003022	BRO family, N-terminal domain; Region: Bro-N; smart01040
359391003023	L-carnitine dehydratase/bile acid-inducible protein F
359391003024	hypothetical
359391003025	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
359391003026	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
359391003027	FAD binding site [chemical binding]; other site
359391003028	substrate binding pocket [chemical binding]; other site
359391003029	catalytic base [active]
359391003030	Transcriptional regulator [Transcription]; Region: LysR; COG0583
359391003031	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
359391003032	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
359391003033	dimerization interface [polypeptide binding]; other site
359391003034	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
359391003035	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
359391003036	multidrug efflux protein; Reviewed; Region: PRK09579
359391003037	MMPL family; Region: MMPL; cl14618
359391003038	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
359391003039	Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169
359391003040	HlyD family secretion protein; Region: HlyD_3; pfam13437
359391003041	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
359391003042	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
359391003043	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
359391003044	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
359391003045	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
359391003046	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
359391003047	active site
359391003048	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
359391003049	active site
359391003050	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
359391003051	active site
359391003052	(T/H)XGH motif; other site
359391003053	DNA gyrase subunit A; Validated; Region: PRK05560
359391003054	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
359391003055	CAP-like domain; other site
359391003056	active site
359391003057	primary dimer interface [polypeptide binding]; other site
359391003058	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
359391003059	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
359391003060	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
359391003061	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
359391003062	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
359391003063	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
359391003064	Uncharacterized component of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3709
359391003065	AAA domain; Region: AAA_33; pfam13671
359391003066	active site
359391003067	phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325
359391003068	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
359391003069	DNA-binding site [nucleotide binding]; DNA binding site
359391003070	UTRA domain; Region: UTRA; pfam07702
359391003071	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
359391003072	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
359391003073	dimer interface [polypeptide binding]; other site
359391003074	ssDNA binding site [nucleotide binding]; other site
359391003075	tetramer (dimer of dimers) interface [polypeptide binding]; other site
359391003076	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
359391003077	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
359391003078	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
359391003079	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
359391003080	histone-like DNA-binding protein HU; Region: HU; cd13831
359391003081	dimer interface [polypeptide binding]; other site
359391003082	DNA binding site [nucleotide binding]
359391003083	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
359391003084	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
359391003085	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
359391003086	Walker A motif; other site
359391003087	ATP binding site [chemical binding]; other site
359391003088	Walker B motif; other site
359391003089	arginine finger; other site
359391003090	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
359391003091	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
359391003092	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
359391003093	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
359391003094	Walker A motif; other site
359391003095	ATP binding site [chemical binding]; other site
359391003096	Walker B motif; other site
359391003097	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
359391003098	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
359391003099	oligomer interface [polypeptide binding]; other site
359391003100	active site residues [active]
359391003101	GTPases [General function prediction only]; Region: HflX; COG2262
359391003102	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
359391003103	HflX GTPase family; Region: HflX; cd01878
359391003104	G1 box; other site
359391003105	GTP/Mg2+ binding site [chemical binding]; other site
359391003106	Switch I region; other site
359391003107	G2 box; other site
359391003108	G3 box; other site
359391003109	Switch II region; other site
359391003110	G4 box; other site
359391003111	G5 box; other site
359391003112	bacterial Hfq-like; Region: Hfq; cd01716
359391003113	hexamer interface [polypeptide binding]; other site
359391003114	Sm1 motif; other site
359391003115	RNA binding site [nucleotide binding]; other site
359391003116	Sm2 motif; other site
359391003117	conserved hypothetical protein
359391003118	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
359391003119	TrkA-N domain; Region: TrkA_N; pfam02254
359391003120	TrkA-C domain; Region: TrkA_C; pfam02080
359391003121	TrkA-N domain; Region: TrkA_N; pfam02254
359391003122	TrkA-C domain; Region: TrkA_C; pfam02080
359391003123	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
359391003124	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
359391003125	active site
359391003126	phosphorylation site [posttranslational modification]
359391003127	intermolecular recognition site; other site
359391003128	dimerization interface [polypeptide binding]; other site
359391003129	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
359391003130	Walker A motif; other site
359391003131	ATP binding site [chemical binding]; other site
359391003132	Walker B motif; other site
359391003133	arginine finger; other site
359391003134	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
359391003135	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
359391003136	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
359391003137	dimerization interface [polypeptide binding]; other site
359391003138	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
359391003139	dimer interface [polypeptide binding]; other site
359391003140	phosphorylation site [posttranslational modification]
359391003141	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
359391003142	ATP binding site [chemical binding]; other site
359391003143	Mg2+ binding site [ion binding]; other site
359391003144	G-X-G motif; other site
359391003145	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
359391003146	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
359391003147	active site
359391003148	phosphorylation site [posttranslational modification]
359391003149	intermolecular recognition site; other site
359391003150	dimerization interface [polypeptide binding]; other site
359391003151	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
359391003152	Walker A motif; other site
359391003153	ATP binding site [chemical binding]; other site
359391003154	Walker B motif; other site
359391003155	arginine finger; other site
359391003156	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
359391003157	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
359391003158	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
359391003159	dimer interface [polypeptide binding]; other site
359391003160	phosphorylation site [posttranslational modification]
359391003161	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
359391003162	ATP binding site [chemical binding]; other site
359391003163	Mg2+ binding site [ion binding]; other site
359391003164	G-X-G motif; other site
359391003165	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
359391003166	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
359391003167	FMN binding site [chemical binding]; other site
359391003168	active site
359391003169	catalytic residues [active]
359391003170	substrate binding site [chemical binding]; other site
359391003171	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
359391003172	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
359391003173	substrate binding site; other site
359391003174	dimer interface; other site
359391003175	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
359391003176	homotrimer interaction site [polypeptide binding]; other site
359391003177	zinc binding site [ion binding]; other site
359391003178	CDP-binding sites; other site
359391003179	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
359391003180	Short-chain dehydrogenase/reductase SDR:Glucose/ribitol dehydrogenase
359391003181	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
359391003182	putative coenzyme Q binding site [chemical binding]; other site
359391003183	lipoyl synthase; Provisional; Region: PRK05481
359391003184	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
359391003185	FeS/SAM binding site; other site
359391003186	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
359391003187	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
359391003188	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
359391003189	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
359391003190	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
359391003191	pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349
359391003192	E3 interaction surface; other site
359391003193	lipoyl attachment site [posttranslational modification]; other site
359391003194	e3 binding domain; Region: E3_binding; pfam02817
359391003195	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
359391003196	pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892
359391003197	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
359391003198	E3 interaction surface; other site
359391003199	lipoyl attachment site [posttranslational modification]; other site
359391003200	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
359391003201	alpha subunit interface [polypeptide binding]; other site
359391003202	TPP binding site [chemical binding]; other site
359391003203	heterodimer interface [polypeptide binding]; other site
359391003204	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
359391003205	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
359391003206	tetramer interface [polypeptide binding]; other site
359391003207	TPP-binding site [chemical binding]; other site
359391003208	heterodimer interface [polypeptide binding]; other site
359391003209	phosphorylation loop region [posttranslational modification]
359391003210	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
359391003211	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
359391003212	S-adenosylmethionine binding site [chemical binding]; other site
359391003213	enolase; Provisional; Region: eno; PRK00077
359391003214	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
359391003215	dimer interface [polypeptide binding]; other site
359391003216	metal binding site [ion binding]; metal-binding site
359391003217	substrate binding pocket [chemical binding]; other site
359391003218	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
359391003219	CTP synthetase; Validated; Region: pyrG; PRK05380
359391003220	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
359391003221	Catalytic site [active]
359391003222	active site
359391003223	UTP binding site [chemical binding]; other site
359391003224	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
359391003225	active site
359391003226	putative oxyanion hole; other site
359391003227	catalytic triad [active]
359391003228	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
359391003229	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
359391003230	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
359391003231	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
359391003232	substrate binding site [chemical binding]; other site
359391003233	dimer interface [polypeptide binding]; other site
359391003234	catalytic triad [active]
359391003235	SurA N-terminal domain; Region: SurA_N_3; cl07813
359391003236	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
359391003237	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
359391003238	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
359391003239	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
359391003240	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
359391003241	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
359391003242	active site
359391003243	ribulose/triose binding site [chemical binding]; other site
359391003244	phosphate binding site [ion binding]; other site
359391003245	substrate (anthranilate) binding pocket [chemical binding]; other site
359391003246	product (indole) binding pocket [chemical binding]; other site
359391003247	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
359391003248	trimer interface [polypeptide binding]; other site
359391003249	dimer interface [polypeptide binding]; other site
359391003250	putative active site [active]
359391003251	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
359391003252	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
359391003253	dimer interface [polypeptide binding]; other site
359391003254	putative functional site; other site
359391003255	putative MPT binding site; other site
359391003256	LexA repressor; Validated; Region: PRK00215
359391003257	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
359391003258	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
359391003259	Catalytic site [active]
359391003260	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
359391003261	Competence protein; Region: Competence; pfam03772
359391003262	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
359391003263	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
359391003264	active site
359391003265	HIGH motif; other site
359391003266	KMSKS motif; other site
359391003267	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
359391003268	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
359391003269	dimer interface [polypeptide binding]; other site
359391003270	active site
359391003271	citrylCoA binding site [chemical binding]; other site
359391003272	NADH binding [chemical binding]; other site
359391003273	cationic pore residues; other site
359391003274	oxalacetate/citrate binding site [chemical binding]; other site
359391003275	coenzyme A binding site [chemical binding]; other site
359391003276	catalytic triad [active]
359391003277	Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763
359391003278	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
359391003279	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3494
359391003280	Acyl-[acyl carrier protein]; Region: LpxA; COG1043
359391003281	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
359391003282	active site
359391003283	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
359391003284	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
359391003285	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
359391003286	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
359391003287	trimer interface [polypeptide binding]; other site
359391003288	active site
359391003289	UDP-GlcNAc binding site [chemical binding]; other site
359391003290	lipid binding site [chemical binding]; lipid-binding site
359391003291	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
359391003292	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
359391003293	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
359391003294	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
359391003295	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
359391003296	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
359391003297	Surface antigen; Region: Bac_surface_Ag; pfam01103
359391003298	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
359391003299	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
359391003300	active site
359391003301	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
359391003302	protein binding site [polypeptide binding]; other site
359391003303	putative substrate binding region [chemical binding]; other site
359391003304	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
359391003305	Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475
359391003306	active site
359391003307	dimer interface [polypeptide binding]; other site
359391003308	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
359391003309	hinge region; other site
359391003310	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
359391003311	putative nucleotide binding site [chemical binding]; other site
359391003312	uridine monophosphate binding site [chemical binding]; other site
359391003313	homohexameric interface [polypeptide binding]; other site
359391003314	elongation factor Ts; Provisional; Region: tsf; PRK09377
359391003315	UBA/TS-N domain; Region: UBA; pfam00627
359391003316	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
359391003317	rRNA interaction site [nucleotide binding]; other site
359391003318	S8 interaction site; other site
359391003319	putative laminin-1 binding site; other site
359391003320	conserved hypothetical protein
359391003321	Domain of unknown function (DUF1849); Region: DUF1849; pfam08904
359391003322	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
359391003323	homotrimer interaction site [polypeptide binding]; other site
359391003324	putative active site [active]
359391003325	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_3; cd08585
359391003326	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
359391003327	putative active site [active]
359391003328	catalytic site [active]
359391003329	putative metal binding site [ion binding]; other site
359391003330	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146
359391003331	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
359391003332	HIT family signature motif; other site
359391003333	catalytic residue [active]
359391003334	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
359391003335	Clp amino terminal domain; Region: Clp_N; pfam02861
359391003336	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
359391003337	Walker A motif; other site
359391003338	ATP binding site [chemical binding]; other site
359391003339	Walker B motif; other site
359391003340	arginine finger; other site
359391003341	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
359391003342	Walker A motif; other site
359391003343	ATP binding site [chemical binding]; other site
359391003344	Walker B motif; other site
359391003345	arginine finger; other site
359391003346	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
359391003347	Uncharacterized conserved protein [Function unknown]; Region: COG2127
359391003348	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
359391003349	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191
359391003350	Sporulation related domain; Region: SPOR; pfam05036
359391003351	Uncharacterized conserved protein [Function unknown]; Region: COG5458
359391003352	Iron-sulfur-dependent L-serine dehydratase single chain form:Serine dehydratase alpha chain:Serine dehydratase beta chain
359391003353	hypothetical
359391003354	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
359391003355	putative active site [active]
359391003356	Predicted membrane protein [Function unknown]; Region: COG3503
359391003357	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
359391003358	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
359391003359	DNA binding residues [nucleotide binding]
359391003360	putative dimer interface [polypeptide binding]; other site
359391003361	conserved hypothetical protein
359391003362	conserved hypothetical protein
359391003363	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
359391003364	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
359391003365	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
359391003366	non-specific DNA binding site [nucleotide binding]; other site
359391003367	salt bridge; other site
359391003368	sequence-specific DNA binding site [nucleotide binding]; other site
359391003369	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
359391003370	Domain of unknown function (DUF955); Region: DUF955; pfam06114
359391003371	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
359391003372	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
359391003373	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
359391003374	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172
359391003375	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
359391003376	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
359391003377	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
359391003378	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
359391003379	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
359391003380	carboxyltransferase (CT) interaction site; other site
359391003381	biotinylation site [posttranslational modification]; other site
359391003382	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
359391003383	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
359391003384	active site
359391003385	substrate binding site [chemical binding]; other site
359391003386	coenzyme B12 binding site [chemical binding]; other site
359391003387	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
359391003388	B12 binding site [chemical binding]; other site
359391003389	cobalt ligand [ion binding]; other site
359391003390	TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123
359391003391	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
359391003392	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
359391003393	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
359391003394	glutamate racemase; Provisional; Region: PRK00865
359391003395	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
359391003396	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
359391003397	intracellular protease, PfpI family; Region: PfpI; TIGR01382
359391003398	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
359391003399	conserved cys residue [active]
359391003400	Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321
359391003401	isocitrate dehydrogenase; Validated; Region: PRK08299
359391003402	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
359391003403	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
359391003404	dimer interface [polypeptide binding]; other site
359391003405	active site
359391003406	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
359391003407	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
359391003408	motif 1; other site
359391003409	active site
359391003410	motif 2; other site
359391003411	motif 3; other site
359391003412	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
359391003413	recombinase A; Provisional; Region: recA; PRK09354
359391003414	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
359391003415	hexamer interface [polypeptide binding]; other site
359391003416	Walker A motif; other site
359391003417	ATP binding site [chemical binding]; other site
359391003418	Walker B motif; other site
359391003419	putative outer membrane lipoprotein; Provisional; Region: PRK10510
359391003420	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
359391003421	ligand binding site [chemical binding]; other site
359391003422	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
359391003423	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
359391003424	N-acetyl-D-glucosamine binding site [chemical binding]; other site
359391003425	catalytic residue [active]
359391003426	recombination factor protein RarA; Reviewed; Region: PRK13342
359391003427	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
359391003428	Walker A motif; other site
359391003429	ATP binding site [chemical binding]; other site
359391003430	Walker B motif; other site
359391003431	arginine finger; other site
359391003432	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
359391003433	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
359391003434	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
359391003435	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
359391003436	protein binding site [polypeptide binding]; other site
359391003437	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
359391003438	protein binding site [polypeptide binding]; other site
359391003439	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
359391003440	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
359391003441	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
359391003442	alphaNTD homodimer interface [polypeptide binding]; other site
359391003443	alphaNTD - beta interaction site [polypeptide binding]; other site
359391003444	alphaNTD - beta' interaction site [polypeptide binding]; other site
359391003445	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
359391003446	30S ribosomal protein S11; Validated; Region: PRK05309
359391003447	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
359391003448	adenylate kinase; Reviewed; Region: adk; PRK00279
359391003449	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
359391003450	AMP-binding site [chemical binding]; other site
359391003451	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
359391003452	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
359391003453	SecY translocase; Region: SecY; pfam00344
359391003454	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
359391003455	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
359391003456	23S rRNA binding site [nucleotide binding]; other site
359391003457	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
359391003458	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
359391003459	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
359391003460	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
359391003461	5S rRNA interface [nucleotide binding]; other site
359391003462	23S rRNA interface [nucleotide binding]; other site
359391003463	L5 interface [polypeptide binding]; other site
359391003464	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
359391003465	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
359391003466	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
359391003467	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
359391003468	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
359391003469	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
359391003470	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
359391003471	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
359391003472	RNA binding site [nucleotide binding]; other site
359391003473	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
359391003474	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
359391003475	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
359391003476	23S rRNA interface [nucleotide binding]; other site
359391003477	putative translocon interaction site; other site
359391003478	signal recognition particle (SRP54) interaction site; other site
359391003479	L23 interface [polypeptide binding]; other site
359391003480	trigger factor interaction site; other site
359391003481	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
359391003482	23S rRNA interface [nucleotide binding]; other site
359391003483	5S rRNA interface [nucleotide binding]; other site
359391003484	putative antibiotic binding site [chemical binding]; other site
359391003485	L25 interface [polypeptide binding]; other site
359391003486	L27 interface [polypeptide binding]; other site
359391003487	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
359391003488	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
359391003489	G-X-X-G motif; other site
359391003490	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
359391003491	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
359391003492	putative translocon binding site; other site
359391003493	protein-rRNA interface [nucleotide binding]; other site
359391003494	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
359391003495	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
359391003496	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
359391003497	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
359391003498	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
359391003499	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
359391003500	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
359391003501	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
359391003502	elongation factor Tu; Reviewed; Region: PRK00049
359391003503	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
359391003504	G1 box; other site
359391003505	GEF interaction site [polypeptide binding]; other site
359391003506	GTP/Mg2+ binding site [chemical binding]; other site
359391003507	Switch I region; other site
359391003508	G2 box; other site
359391003509	G3 box; other site
359391003510	Switch II region; other site
359391003511	G4 box; other site
359391003512	G5 box; other site
359391003513	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
359391003514	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
359391003515	Antibiotic Binding Site [chemical binding]; other site
359391003516	elongation factor G; Reviewed; Region: PRK00007
359391003517	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
359391003518	G1 box; other site
359391003519	putative GEF interaction site [polypeptide binding]; other site
359391003520	GTP/Mg2+ binding site [chemical binding]; other site
359391003521	Switch I region; other site
359391003522	G2 box; other site
359391003523	G3 box; other site
359391003524	Switch II region; other site
359391003525	G4 box; other site
359391003526	G5 box; other site
359391003527	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
359391003528	Elongation Factor G, domain II; Region: EFG_II; pfam14492
359391003529	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
359391003530	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
359391003531	30S ribosomal protein S7; Validated; Region: PRK05302
359391003532	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
359391003533	S17 interaction site [polypeptide binding]; other site
359391003534	S8 interaction site; other site
359391003535	16S rRNA interaction site [nucleotide binding]; other site
359391003536	streptomycin interaction site [chemical binding]; other site
359391003537	23S rRNA interaction site [nucleotide binding]; other site
359391003538	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
359391003539	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
359391003540	Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609
359391003541	beta and beta' interface [polypeptide binding]; other site
359391003542	beta' and sigma factor interface [polypeptide binding]; other site
359391003543	Zn-binding [ion binding]; other site
359391003544	active site region [active]
359391003545	catalytic site [active]
359391003546	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
359391003547	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
359391003548	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
359391003549	G-loop; other site
359391003550	DNA binding site [nucleotide binding]
359391003551	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
359391003552	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
359391003553	RPB12 interaction site [polypeptide binding]; other site
359391003554	RPB1 interaction site [polypeptide binding]; other site
359391003555	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
359391003556	RPB10 interaction site [polypeptide binding]; other site
359391003557	RPB11 interaction site [polypeptide binding]; other site
359391003558	RPB3 interaction site [polypeptide binding]; other site
359391003559	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
359391003560	core dimer interface [polypeptide binding]; other site
359391003561	peripheral dimer interface [polypeptide binding]; other site
359391003562	L10 interface [polypeptide binding]; other site
359391003563	L11 interface [polypeptide binding]; other site
359391003564	putative EF-Tu interaction site [polypeptide binding]; other site
359391003565	putative EF-G interaction site [polypeptide binding]; other site
359391003566	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
359391003567	23S rRNA interface [nucleotide binding]; other site
359391003568	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
359391003569	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
359391003570	mRNA/rRNA interface [nucleotide binding]; other site
359391003571	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
359391003572	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
359391003573	23S rRNA interface [nucleotide binding]; other site
359391003574	L7/L12 interface [polypeptide binding]; other site
359391003575	putative thiostrepton binding site; other site
359391003576	L25 interface [polypeptide binding]; other site
359391003577	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
359391003578	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
359391003579	putative homodimer interface [polypeptide binding]; other site
359391003580	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
359391003581	heterodimer interface [polypeptide binding]; other site
359391003582	homodimer interface [polypeptide binding]; other site
359391003583	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
359391003584	elongation factor Tu; Reviewed; Region: PRK00049
359391003585	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
359391003586	G1 box; other site
359391003587	GEF interaction site [polypeptide binding]; other site
359391003588	GTP/Mg2+ binding site [chemical binding]; other site
359391003589	Switch I region; other site
359391003590	G2 box; other site
359391003591	G3 box; other site
359391003592	Switch II region; other site
359391003593	G4 box; other site
359391003594	G5 box; other site
359391003595	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
359391003596	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
359391003597	Antibiotic Binding Site [chemical binding]; other site
359391003598	FOG: CBS domain [General function prediction only]; Region: COG0517
359391003599	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
359391003600	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
359391003601	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388
359391003602	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: Peptidase_C93; pfam06035
359391003603	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
359391003604	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
359391003605	trimer interface [polypeptide binding]; other site
359391003606	putative metal binding site [ion binding]; other site
359391003607	Protein of unknown function (DUF3126); Region: DUF3126; pfam11324
359391003608	serine acetyltransferase; Provisional; Region: cysE; PRK11132
359391003609	Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971
359391003610	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
359391003611	trimer interface [polypeptide binding]; other site
359391003612	active site
359391003613	substrate binding site [chemical binding]; other site
359391003614	CoA binding site [chemical binding]; other site
359391003615	Putative lysophospholipase; Region: Hydrolase_4; cl19140
359391003616	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
359391003617	Uncharacterized conserved protein [Function unknown]; Region: COG1430
359391003618	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
359391003619	DNA-binding site [nucleotide binding]; DNA binding site
359391003620	RNA-binding motif; other site
359391003621	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
359391003622	DNA-binding site [nucleotide binding]; DNA binding site
359391003623	RNA-binding motif; other site
359391003624	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
359391003625	dimer interface [polypeptide binding]; other site
359391003626	active site
359391003627	metal binding site [ion binding]; metal-binding site
359391003628	glutathione binding site [chemical binding]; other site
359391003629	conserved hypothetical protein
359391003630	conserved hypothetical protein
359391003631	conserved hypothetical protein
359391003632	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
359391003633	DHH family; Region: DHH; pfam01368
359391003634	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
359391003635	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
359391003636	ATP-grasp domain; Region: ATP-grasp_4; cl17255
359391003637	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
359391003638	putative active site [active]
359391003639	homoserine dehydrogenase; Provisional; Region: PRK06349
359391003640	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
359391003641	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
359391003642	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
359391003643	aminotransferase; Validated; Region: PRK09148
359391003644	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
359391003645	pyridoxal 5'-phosphate binding site [chemical binding]; other site
359391003646	homodimer interface [polypeptide binding]; other site
359391003647	catalytic residue [active]
359391003648	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
359391003649	Peptidase M15; Region: Peptidase_M15_3; cl01194
359391003650	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3553
359391003651	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
359391003652	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
359391003653	active site
359391003654	hypothetical protein; Reviewed; Region: PRK00024
359391003655	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
359391003656	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
359391003657	MPN+ (JAMM) motif; other site
359391003658	Zinc-binding site [ion binding]; other site
359391003659	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
359391003660	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
359391003661	active site
359391003662	putative homodimer interface [polypeptide binding]; other site
359391003663	SAM binding site [chemical binding]; other site
359391003664	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
359391003665	S-adenosylmethionine binding site [chemical binding]; other site
359391003666	precorrin-3B synthase; Region: CobG; TIGR02435
359391003667	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
359391003668	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
359391003669	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
359391003670	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
359391003671	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
359391003672	active site
359391003673	SAM binding site [chemical binding]; other site
359391003674	homodimer interface [polypeptide binding]; other site
359391003675	Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073
359391003676	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
359391003677	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
359391003678	active site
359391003679	SAM binding site [chemical binding]; other site
359391003680	homodimer interface [polypeptide binding]; other site
359391003681	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
359391003682	phospholipase/carboxylesterase family protein
359391003683	monooxygenase, putative
359391003684	monooxygenase, putative
359391003685	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
359391003686	Receptor family ligand binding region; Region: ANF_receptor; pfam01094
359391003687	ligand binding site [chemical binding]; other site
359391003688	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
359391003689	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
359391003690	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
359391003691	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
359391003692	pyridoxal 5'-phosphate binding site [chemical binding]; other site
359391003693	homodimer interface [polypeptide binding]; other site
359391003694	catalytic residue [active]
359391003695	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
359391003696	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
359391003697	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
359391003698	conserved cys residue [active]
359391003699	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
359391003700	active site
359391003701	SAM binding site [chemical binding]; other site
359391003702	homodimer interface [polypeptide binding]; other site
359391003703	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
359391003704	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
359391003705	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
359391003706	active site
359391003707	SAM binding site [chemical binding]; other site
359391003708	homodimer interface [polypeptide binding]; other site
359391003709	Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073
359391003710	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
359391003711	tellurium resistance terB-like protein; Region: terB_like; cd07177
359391003712	metal binding site [ion binding]; metal-binding site
359391003713	hypothetical protein; Provisional; Region: PRK10621
359391003714	Predicted membrane protein [Function unknown]; Region: COG2510
359391003715	Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557
359391003716	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
359391003717	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
359391003718	homodimer interface [polypeptide binding]; other site
359391003719	Walker A motif; other site
359391003720	ATP binding site [chemical binding]; other site
359391003721	hydroxycobalamin binding site [chemical binding]; other site
359391003722	Walker B motif; other site
359391003723	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
359391003724	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
359391003725	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
359391003726	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
359391003727	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
359391003728	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
359391003729	homotrimer interface [polypeptide binding]; other site
359391003730	Walker A motif; other site
359391003731	GTP binding site [chemical binding]; other site
359391003732	Walker B motif; other site
359391003733	conserved hypothetical protein
359391003734	cobalt transporter subunit CbtB (proposed); Region: CbtB; TIGR02459
359391003735	cobyric acid synthase; Provisional; Region: PRK00784
359391003736	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
359391003737	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
359391003738	catalytic triad [active]
359391003739	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
359391003740	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
359391003741	Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162
359391003742	substrate binding pocket [chemical binding]; other site
359391003743	FAD binding site [chemical binding]; other site
359391003744	catalytic base [active]
359391003745	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
359391003746	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
359391003747	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833
359391003748	Predicted small secreted protein [Function unknown]; Region: COG5510
359391003749	Transcriptional regulator [Transcription]; Region: LysR; COG0583
359391003750	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
359391003751	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
359391003752	dimerization interface [polypeptide binding]; other site
359391003753	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
359391003754	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
359391003755	conserved cys residue [active]
359391003756	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
359391003757	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
359391003758	sarcosine dehydrogenase
359391003759	Glycine cleavage T protein (aminomethyl transferase)
359391003760	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
359391003761	Protein of unknown function (DUF1673); Region: DUF1673; pfam07895
359391003762	Mechanosensitive ion channel; Region: MS_channel; pfam00924
359391003763	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
359391003764	SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136
359391003765	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
359391003766	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
359391003767	Protein export membrane protein; Region: SecD_SecF; pfam02355
359391003768	putative cation:proton antiport protein; Provisional; Region: PRK10669
359391003769	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
359391003770	TrkA-N domain; Region: TrkA_N; pfam02254
359391003771	Predicted integral membrane protein [Function unknown]; Region: COG0392
359391003772	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
359391003773	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
359391003774	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
359391003775	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391003776	dimer interface [polypeptide binding]; other site
359391003777	conserved gate region; other site
359391003778	putative PBP binding loops; other site
359391003779	ABC-ATPase subunit interface; other site
359391003780	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
359391003781	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391003782	dimer interface [polypeptide binding]; other site
359391003783	conserved gate region; other site
359391003784	putative PBP binding loops; other site
359391003785	ABC-ATPase subunit interface; other site
359391003786	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CysP; COG4150
359391003787	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; cl19202
359391003788	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
359391003789	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
359391003790	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
359391003791	Transporter associated domain; Region: CorC_HlyC; smart01091
359391003792	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
359391003793	EF-hand domain pair; Region: EF-hand_7; pfam13499
359391003794	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
359391003795	Ca2+ binding site [ion binding]; other site
359391003796	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
359391003797	Ca2+ binding site [ion binding]; other site
359391003798	Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154
359391003799	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
359391003800	classical (c) SDRs; Region: SDR_c; cd05233
359391003801	NAD(P) binding site [chemical binding]; other site
359391003802	active site
359391003803	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
359391003804	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
359391003805	Walker A/P-loop; other site
359391003806	ATP binding site [chemical binding]; other site
359391003807	Q-loop/lid; other site
359391003808	ABC transporter signature motif; other site
359391003809	Walker B; other site
359391003810	D-loop; other site
359391003811	H-loop/switch region; other site
359391003812	Bacterial inner-membrane translocator
359391003813	sugar ABC transporter, permease protein KO: K02057 simple sugar transport system permease protein
359391003814	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312
359391003815	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
359391003816	putative ligand binding site [chemical binding]; other site
359391003817	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
359391003818	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
359391003819	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
359391003820	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
359391003821	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
359391003822	Walker A/P-loop; other site
359391003823	ATP binding site [chemical binding]; other site
359391003824	Q-loop/lid; other site
359391003825	ABC transporter signature motif; other site
359391003826	Walker B; other site
359391003827	D-loop; other site
359391003828	H-loop/switch region; other site
359391003829	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
359391003830	ABC-ATPase subunit  interface; other site
359391003831	dimer interface [polypeptide binding]; other site
359391003832	putative PBP binding regions; other site
359391003833	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
359391003834	PTHB1 N-terminus; Region: PHTB1_N; pfam14727
359391003835	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
359391003836	intersubunit interface [polypeptide binding]; other site
359391003837	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
359391003838	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
359391003839	N-terminal plug; other site
359391003840	ligand-binding site [chemical binding]; other site
359391003841	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
359391003842	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
359391003843	ABC transporter ATP-binding protein
359391003844	ATP/GTP-binding site motif A (P-loop):ABC transporter:AAA ATPase
359391003845	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
359391003846	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
359391003847	HlyD family secretion protein; Region: HlyD_3; pfam13437
359391003848	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
359391003849	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
359391003850	alpha-gamma subunit interface [polypeptide binding]; other site
359391003851	beta-gamma subunit interface [polypeptide binding]; other site
359391003852	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
359391003853	alpha-beta subunit interface [polypeptide binding]; other site
359391003854	urease subunit alpha; Reviewed; Region: ureC; PRK13309
359391003855	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
359391003856	subunit interactions [polypeptide binding]; other site
359391003857	active site
359391003858	flap region; other site
359391003859	UreE urease accessory, N-terminal
359391003860	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
359391003861	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
359391003862	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
359391003863	Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413
359391003864	ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266
359391003865	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
359391003866	cobalt transport protein CbiM; Validated; Region: PRK06265
359391003867	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
359391003868	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
359391003869	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
359391003870	Walker A/P-loop; other site
359391003871	ATP binding site [chemical binding]; other site
359391003872	Q-loop/lid; other site
359391003873	ABC transporter signature motif; other site
359391003874	Walker B; other site
359391003875	D-loop; other site
359391003876	H-loop/switch region; other site
359391003877	camphor resistance protein CrcB; Provisional; Region: ccrB; PRK01636
359391003878	Uncharacterized conserved protein [Function unknown]; Region: COG3439
359391003879	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
359391003880	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
359391003881	NUDIX domain; Region: NUDIX; pfam00293
359391003882	nudix motif; other site
359391003883	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
359391003884	putative catalytic site [active]
359391003885	putative metal binding site [ion binding]; other site
359391003886	putative phosphate binding site [ion binding]; other site
359391003887	BA14K-like protein; Region: BA14K; pfam07886
359391003888	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
359391003889	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
359391003890	pyridoxal 5'-phosphate binding site [chemical binding]; other site
359391003891	homodimer interface [polypeptide binding]; other site
359391003892	catalytic residue [active]
359391003893	ketol-acid reductoisomerase; Provisional; Region: PRK05479
359391003894	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
359391003895	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
359391003896	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
359391003897	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
359391003898	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
359391003899	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
359391003900	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
359391003901	active site
359391003902	hydrophilic channel; other site
359391003903	dimerization interface [polypeptide binding]; other site
359391003904	catalytic residues [active]
359391003905	active site lid [active]
359391003906	SpoIIAA-like; Region: SpoIIAA-like; pfam11964
359391003907	ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507
359391003908	AAA domain; Region: AAA_30; pfam13604
359391003909	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
359391003910	Walker A motif; other site
359391003911	ATP binding site [chemical binding]; other site
359391003912	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
359391003913	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
359391003914	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
359391003915	putative valine binding site [chemical binding]; other site
359391003916	dimer interface [polypeptide binding]; other site
359391003917	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
359391003918	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107
359391003919	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
359391003920	PYR/PP interface [polypeptide binding]; other site
359391003921	dimer interface [polypeptide binding]; other site
359391003922	TPP binding site [chemical binding]; other site
359391003923	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
359391003924	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
359391003925	TPP-binding site [chemical binding]; other site
359391003926	dimer interface [polypeptide binding]; other site
359391003927	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
359391003928	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
359391003929	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
359391003930	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
359391003931	motif II; other site
359391003932	Predicted flavoproteins [General function prediction only]; Region: COG2081
359391003933	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
359391003934	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
359391003935	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
359391003936	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
359391003937	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
359391003938	protein binding site [polypeptide binding]; other site
359391003939	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
359391003940	protein binding site [polypeptide binding]; other site
359391003941	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242
359391003942	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
359391003943	High frequency of lysogenization C (HflC) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflC; cd03405
359391003944	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
359391003945	High frequency of lysogenization K (HflK) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflK; cd03404
359391003946	HflK protein; Region: hflK; TIGR01933
359391003947	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
359391003948	folate binding site [chemical binding]; other site
359391003949	NADP+ binding site [chemical binding]; other site
359391003950	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
359391003951	dimerization interface [polypeptide binding]; other site
359391003952	active site
359391003953	Protein of unknown function (DUF2853); Region: DUF2853; pfam11015
359391003954	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
359391003955	putative substrate translocation pore; other site
359391003956	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
359391003957	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
359391003958	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
359391003959	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814
359391003960	Domain of unknown function (DUF4169); Region: DUF4169; pfam13770
359391003961	Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321
359391003962	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
359391003963	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
359391003964	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
359391003965	FAD binding domain; Region: FAD_binding_4; pfam01565
359391003966	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
359391003967	Uncharacterized conserved protein [Function unknown]; Region: COG4702
359391003968	serine/threonine protein kinase; Provisional; Region: PRK09188
359391003969	serine/threonine protein kinase; Provisional; Region: PRK12274
359391003970	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
359391003971	Part of AAA domain; Region: AAA_19; pfam13245
359391003972	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
359391003973	Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045
359391003974	phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308
359391003975	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
359391003976	trimer interface [polypeptide binding]; other site
359391003977	active site
359391003978	substrate binding site [chemical binding]; other site
359391003979	CoA binding site [chemical binding]; other site
359391003980	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
359391003981	Cu(I) binding site [ion binding]; other site
359391003982	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
359391003983	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
359391003984	S-adenosylmethionine binding site [chemical binding]; other site
359391003985	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
359391003986	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
359391003987	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
359391003988	active site
359391003989	Uncharacterized conserved protein [Function unknown]; Region: COG5587
359391003990	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
359391003991	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
359391003992	nucleotide binding pocket [chemical binding]; other site
359391003993	K-X-D-G motif; other site
359391003994	catalytic site [active]
359391003995	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
359391003996	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
359391003997	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
359391003998	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
359391003999	Dimer interface [polypeptide binding]; other site
359391004000	BRCT sequence motif; other site
359391004001	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
359391004002	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
359391004003	Walker A/P-loop; other site
359391004004	ATP binding site [chemical binding]; other site
359391004005	Q-loop/lid; other site
359391004006	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
359391004007	ABC transporter signature motif; other site
359391004008	Walker B; other site
359391004009	D-loop; other site
359391004010	H-loop/switch region; other site
359391004011	DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105
359391004012	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
359391004013	binding surface
359391004014	TPR motif; other site
359391004015	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
359391004016	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
359391004017	cell division protein FtsZ; Validated; Region: PRK09330
359391004018	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
359391004019	nucleotide binding site [chemical binding]; other site
359391004020	SulA interaction site; other site
359391004021	cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483
359391004022	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
359391004023	Cell division protein FtsA; Region: FtsA; smart00842
359391004024	Cell division protein FtsA; Region: FtsA; pfam14450
359391004025	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
359391004026	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
359391004027	Cell division protein FtsQ; Region: FtsQ; pfam03799
359391004028	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
359391004029	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
359391004030	ATP-grasp domain; Region: ATP-grasp_4; cl17255
359391004031	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
359391004032	FAD binding domain; Region: FAD_binding_4; cl19922
359391004033	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
359391004034	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
359391004035	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
359391004036	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
359391004037	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
359391004038	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
359391004039	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
359391004040	active site
359391004041	homodimer interface [polypeptide binding]; other site
359391004042	cell division protein FtsW; Region: ftsW; TIGR02614
359391004043	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390
359391004044	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
359391004045	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
359391004046	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
359391004047	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
359391004048	Mg++ binding site [ion binding]; other site
359391004049	putative catalytic motif [active]
359391004050	putative substrate binding site [chemical binding]; other site
359391004051	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093
359391004052	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
359391004053	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
359391004054	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
359391004055	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
359391004056	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
359391004057	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
359391004058	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
359391004059	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
359391004060	Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717
359391004061	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
359391004062	Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462
359391004063	MraW methylase family; Region: Methyltransf_5; cl17771
359391004064	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
359391004065	S-adenosylmethionine binding site [chemical binding]; other site
359391004066	Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257
359391004067	manganese transport protein MntH; Reviewed; Region: PRK00701
359391004068	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
359391004069	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
359391004070	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
359391004071	N-acetyl-D-glucosamine binding site [chemical binding]; other site
359391004072	catalytic residue [active]
359391004073	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
359391004074	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
359391004075	amidase catalytic site [active]
359391004076	Zn binding residues [ion binding]; other site
359391004077	substrate binding site [chemical binding]; other site
359391004078	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
359391004079	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
359391004080	DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076
359391004081	putative metal binding site [ion binding]; other site
359391004082	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
359391004083	HSP70 interaction site [polypeptide binding]; other site
359391004084	Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757
359391004085	Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413
359391004086	active site
359391004087	Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951
359391004088	Transglycosylase SLT domain; Region: SLT_2; pfam13406
359391004089	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
359391004090	Predicted permeases [General function prediction only]; Region: COG0679
359391004091	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
359391004092	FAD binding site [chemical binding]; other site
359391004093	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
359391004094	dimerization interface [polypeptide binding]; other site
359391004095	putative DNA binding site [nucleotide binding]; other site
359391004096	putative Zn2+ binding site [ion binding]; other site
359391004097	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
359391004098	S-adenosylmethionine binding site [chemical binding]; other site
359391004099	Uncharacterized conserved protein [Function unknown]; Region: COG5586
359391004100	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
359391004101	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
359391004102	putative substrate translocation pore; other site
359391004103	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
359391004104	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
359391004105	S-adenosylmethionine binding site [chemical binding]; other site
359391004106	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
359391004107	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
359391004108	ABC transporter; Region: ABC_tran_2; pfam12848
359391004109	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
359391004110	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
359391004111	Putative lysophospholipase; Region: Hydrolase_4; cl19140
359391004112	Putative lysophospholipase; Region: Hydrolase_4; cl19140
359391004113	conserved hypothetical protein
359391004114	conserved hypothetical protein
359391004115	conserved hypothetical protein
359391004116	conserved hypothetical protein
359391004117	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
359391004118	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
359391004119	[2Fe-2S] cluster binding site [ion binding]; other site
359391004120	C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884
359391004121	putative alpha subunit interface [polypeptide binding]; other site
359391004122	putative active site [active]
359391004123	putative substrate binding site [chemical binding]; other site
359391004124	Fe binding site [ion binding]; other site
359391004125	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
359391004126	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
359391004127	FAD binding pocket [chemical binding]; other site
359391004128	FAD binding motif [chemical binding]; other site
359391004129	phosphate binding motif [ion binding]; other site
359391004130	beta-alpha-beta structure motif; other site
359391004131	NAD binding pocket [chemical binding]; other site
359391004132	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
359391004133	catalytic loop [active]
359391004134	iron binding site [ion binding]; other site
359391004135	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
359391004136	PhnA protein; Region: PhnA; pfam03831
359391004137	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
359391004138	catalytic triad [active]
359391004139	metal binding site [ion binding]; metal-binding site
359391004140	conserved cis-peptide bond; other site
359391004141	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899
359391004142	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
359391004143	active site
359391004144	outer membrane protein; Region: OMP_w_GlyGly; TIGR04219
359391004145	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
359391004146	active site
359391004147	catalytic residues [active]
359391004148	DNA binding site [nucleotide binding]
359391004149	Int/Topo IB signature motif; other site
359391004150	Uncharacterized conserved protein [Function unknown]; Region: COG2968
359391004151	hypothetical protein; Provisional; Region: PRK05170
359391004152	Uncharacterized conserved protein [Function unknown]; Region: COG5453
359391004153	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
359391004154	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
359391004155	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
359391004156	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
359391004157	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
359391004158	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
359391004159	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
359391004160	DNA binding residues [nucleotide binding]
359391004161	DNA primase; Validated; Region: dnaG; PRK05667
359391004162	CHC2 zinc finger; Region: zf-CHC2; cl17510
359391004163	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
359391004164	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
359391004165	active site
359391004166	metal binding site [ion binding]; metal-binding site
359391004167	interdomain interaction site; other site
359391004168	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
359391004169	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
359391004170	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
359391004171	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
359391004172	PhoU domain; Region: PhoU; pfam01895
359391004173	PhoU domain; Region: PhoU; pfam01895
359391004174	Uncharacterized conserved protein [Function unknown]; Region: COG1610
359391004175	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
359391004176	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
359391004177	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
359391004178	catalytic site [active]
359391004179	subunit interface [polypeptide binding]; other site
359391004180	Predicted metalloprotease [General function prediction only]; Region: COG2321
359391004181	Predicted membrane protein [Function unknown]; Region: COG5395
359391004182	conserved hypothetical protein
359391004183	conserved hypothetical protein
359391004184	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
359391004185	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
359391004186	ATP-grasp domain; Region: ATP-grasp_4; cl17255
359391004187	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096
359391004188	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
359391004189	ATP-grasp domain; Region: ATP-grasp_4; cl17255
359391004190	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
359391004191	IMP binding site; other site
359391004192	dimer interface [polypeptide binding]; other site
359391004193	partial ornithine binding site; other site
359391004194	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
359391004195	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
359391004196	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
359391004197	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
359391004198	nudix motif; other site
359391004199	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
359391004200	DNA-binding site [nucleotide binding]; DNA binding site
359391004201	RNA-binding motif; other site
359391004202	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
359391004203	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
359391004204	putative C-terminal domain interface [polypeptide binding]; other site
359391004205	putative GSH binding site (G-site) [chemical binding]; other site
359391004206	putative dimer interface [polypeptide binding]; other site
359391004207	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
359391004208	N-terminal domain interface [polypeptide binding]; other site
359391004209	dimer interface [polypeptide binding]; other site
359391004210	substrate binding pocket (H-site) [chemical binding]; other site
359391004211	aspartate aminotransferase; Provisional; Region: PRK05764
359391004212	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
359391004213	pyridoxal 5'-phosphate binding site [chemical binding]; other site
359391004214	homodimer interface [polypeptide binding]; other site
359391004215	catalytic residue [active]
359391004216	Transcriptional regulator [Transcription]; Region: LysR; COG0583
359391004217	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
359391004218	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
359391004219	putative effector binding pocket; other site
359391004220	dimerization interface [polypeptide binding]; other site
359391004221	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
359391004222	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
359391004223	Cation transport protein; Region: TrkH; cl17365
359391004224	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
359391004225	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
359391004226	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
359391004227	putative DNA binding site [nucleotide binding]; other site
359391004228	putative Zn2+ binding site [ion binding]; other site
359391004229	AsnC family; Region: AsnC_trans_reg; pfam01037
359391004230	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
359391004231	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
359391004232	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
359391004233	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
359391004234	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
359391004235	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
359391004236	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
359391004237	EamA-like transporter family; Region: EamA; pfam00892
359391004238	EamA-like transporter family; Region: EamA; pfam00892
359391004239	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3169
359391004240	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921
359391004241	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
359391004242	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
359391004243	Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991
359391004244	Bacterial SH3 domain; Region: SH3_3; pfam08239
359391004245	excinuclease ABC subunit B; Provisional; Region: PRK05298
359391004246	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
359391004247	ATP binding site [chemical binding]; other site
359391004248	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
359391004249	nucleotide binding region [chemical binding]; other site
359391004250	ATP-binding site [chemical binding]; other site
359391004251	Ultra-violet resistance protein B; Region: UvrB; pfam12344
359391004252	UvrB/uvrC motif; Region: UVR; pfam02151
359391004253	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
359391004254	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
359391004255	N-acetyl-D-glucosamine binding site [chemical binding]; other site
359391004256	catalytic residue [active]
359391004257	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
359391004258	DNA-binding site [nucleotide binding]; DNA binding site
359391004259	RNA-binding motif; other site
359391004260	BA14K-like protein; Region: BA14K; pfam07886
359391004261	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
359391004262	Transcriptional regulators [Transcription]; Region: MarR; COG1846
359391004263	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
359391004264	dimerization interface [polypeptide binding]; other site
359391004265	putative Zn2+ binding site [ion binding]; other site
359391004266	putative DNA binding site [nucleotide binding]; other site
359391004267	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
359391004268	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
359391004269	active site
359391004270	phosphorylation site [posttranslational modification]
359391004271	intermolecular recognition site; other site
359391004272	dimerization interface [polypeptide binding]; other site
359391004273	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
359391004274	DNA binding site [nucleotide binding]
359391004275	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
359391004276	HAMP domain; Region: HAMP; pfam00672
359391004277	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
359391004278	dimer interface [polypeptide binding]; other site
359391004279	phosphorylation site [posttranslational modification]
359391004280	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
359391004281	ATP binding site [chemical binding]; other site
359391004282	Mg2+ binding site [ion binding]; other site
359391004283	G-X-G motif; other site
359391004284	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
359391004285	dimer interface [polypeptide binding]; other site
359391004286	putative tRNA-binding site [nucleotide binding]; other site
359391004287	Uncharacterized conserved protein [Function unknown]; Region: COG5465
359391004288	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960
359391004289	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
359391004290	Uncharacterized conserved protein [Function unknown]; Region: COG1565
359391004291	Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636
359391004292	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
359391004293	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
359391004294	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
359391004295	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
359391004296	active site
359391004297	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
359391004298	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
359391004299	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
359391004300	active site
359391004301	HerA helicase [Replication, recombination, and repair]; Region: COG0433
359391004302	AAA ATPase domain; Region: AAA_16; pfam13191
359391004303	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
359391004304	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
359391004305	5S rRNA interface [nucleotide binding]; other site
359391004306	CTC domain interface [polypeptide binding]; other site
359391004307	L16 interface [polypeptide binding]; other site
359391004308	Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693
359391004309	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
359391004310	putative active site [active]
359391004311	catalytic residue [active]
359391004312	GTP-binding protein YchF; Reviewed; Region: PRK09601
359391004313	YchF GTPase; Region: YchF; cd01900
359391004314	G1 box; other site
359391004315	GTP/Mg2+ binding site [chemical binding]; other site
359391004316	Switch I region; other site
359391004317	G2 box; other site
359391004318	Switch II region; other site
359391004319	G3 box; other site
359391004320	G4 box; other site
359391004321	G5 box; other site
359391004322	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
359391004323	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
359391004324	putative active site [active]
359391004325	putative catalytic site [active]
359391004326	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
359391004327	putative active site [active]
359391004328	putative catalytic site [active]
359391004329	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
359391004330	active site
359391004331	Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857
359391004332	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
359391004333	cytochrome b; Provisional; Region: CYTB; MTH00191
359391004334	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
359391004335	Qi binding site; other site
359391004336	intrachain domain interface; other site
359391004337	interchain domain interface [polypeptide binding]; other site
359391004338	heme bH binding site [chemical binding]; other site
359391004339	heme bL binding site [chemical binding]; other site
359391004340	Qo binding site; other site
359391004341	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
359391004342	interchain domain interface [polypeptide binding]; other site
359391004343	intrachain domain interface; other site
359391004344	Qi binding site; other site
359391004345	Qo binding site; other site
359391004346	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
359391004347	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
359391004348	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
359391004349	[2Fe-2S] cluster binding site [ion binding]; other site
359391004350	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
359391004351	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
359391004352	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
359391004353	Walker A/P-loop; other site
359391004354	ATP binding site [chemical binding]; other site
359391004355	Q-loop/lid; other site
359391004356	ABC transporter signature motif; other site
359391004357	Walker B; other site
359391004358	D-loop; other site
359391004359	H-loop/switch region; other site
359391004360	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
359391004361	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
359391004362	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
359391004363	Walker A/P-loop; other site
359391004364	ATP binding site [chemical binding]; other site
359391004365	Q-loop/lid; other site
359391004366	ABC transporter signature motif; other site
359391004367	Walker B; other site
359391004368	D-loop; other site
359391004369	H-loop/switch region; other site
359391004370	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
359391004371	Purine nucleoside permease [Nucleotide transport and metabolism]; Region: NUP; COG5042
359391004372	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
359391004373	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
359391004374	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
359391004375	Coenzyme A binding pocket [chemical binding]; other site
359391004376	aspartyl/asparaginyl beta-hydroxylase
359391004377	lipid A-myristate beta-hydroxylase
359391004378	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
359391004379	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
359391004380	active site
359391004381	NTP binding site [chemical binding]; other site
359391004382	metal binding triad [ion binding]; metal-binding site
359391004383	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
359391004384	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
359391004385	putative active site [active]
359391004386	putative CoA binding site [chemical binding]; other site
359391004387	nudix motif; other site
359391004388	metal binding site [ion binding]; metal-binding site
359391004389	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816
359391004390	MoxR-like ATPases [General function prediction only]; Region: COG0714
359391004391	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
359391004392	Walker A motif; other site
359391004393	ATP binding site [chemical binding]; other site
359391004394	Walker B motif; other site
359391004395	arginine finger; other site
359391004396	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
359391004397	Protein of unknown function DUF58; Region: DUF58; pfam01882
359391004398	N-terminal double-transmembrane domain; Region: two_anch; TIGR02226
359391004399	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
359391004400	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
359391004401	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
359391004402	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
359391004403	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
359391004404	Coenzyme A binding pocket [chemical binding]; other site
359391004405	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
359391004406	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
359391004407	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
359391004408	putative dimer interface [polypeptide binding]; other site
359391004409	N-terminal domain interface [polypeptide binding]; other site
359391004410	putative substrate binding pocket (H-site) [chemical binding]; other site
359391004411	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
359391004412	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680
359391004413	nudix motif; other site
359391004414	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
359391004415	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
359391004416	putative active site [active]
359391004417	putative metal binding site [ion binding]; other site
359391004418	2-isopropylmalate synthase; Validated; Region: PRK03739
359391004419	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
359391004420	active site
359391004421	catalytic residues [active]
359391004422	metal binding site [ion binding]; metal-binding site
359391004423	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
359391004424	anthranilate synthase; Provisional; Region: PRK13566
359391004425	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
359391004426	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
359391004427	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
359391004428	glutamine binding [chemical binding]; other site
359391004429	catalytic triad [active]
359391004430	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
359391004431	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
359391004432	putative DNA binding site [nucleotide binding]; other site
359391004433	putative Zn2+ binding site [ion binding]; other site
359391004434	AsnC family; Region: AsnC_trans_reg; pfam01037
359391004435	Transcriptional regulators [Transcription]; Region: MarR; COG1846
359391004436	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
359391004437	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
359391004438	Major Facilitator Superfamily; Region: MFS_1; pfam07690
359391004439	putative substrate translocation pore; other site
359391004440	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG5459
359391004441	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5345
359391004442	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
359391004443	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391004444	dimer interface [polypeptide binding]; other site
359391004445	conserved gate region; other site
359391004446	putative PBP binding loops; other site
359391004447	ABC-ATPase subunit interface; other site
359391004448	choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415
359391004449	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
359391004450	Walker A/P-loop; other site
359391004451	ATP binding site [chemical binding]; other site
359391004452	Q-loop/lid; other site
359391004453	ABC transporter signature motif; other site
359391004454	Walker B; other site
359391004455	D-loop; other site
359391004456	H-loop/switch region; other site
359391004457	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
359391004458	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
359391004459	Walker A/P-loop; other site
359391004460	ATP binding site [chemical binding]; other site
359391004461	Q-loop/lid; other site
359391004462	ABC transporter signature motif; other site
359391004463	Walker B; other site
359391004464	D-loop; other site
359391004465	H-loop/switch region; other site
359391004466	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
359391004467	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
359391004468	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
359391004469	Walker A/P-loop; other site
359391004470	ATP binding site [chemical binding]; other site
359391004471	Q-loop/lid; other site
359391004472	ABC transporter signature motif; other site
359391004473	Walker B; other site
359391004474	D-loop; other site
359391004475	H-loop/switch region; other site
359391004476	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
359391004477	dipeptide transporter; Provisional; Region: PRK10913
359391004478	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
359391004479	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391004480	dimer interface [polypeptide binding]; other site
359391004481	conserved gate region; other site
359391004482	putative PBP binding loops; other site
359391004483	ABC-ATPase subunit interface; other site
359391004484	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
359391004485	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391004486	dimer interface [polypeptide binding]; other site
359391004487	conserved gate region; other site
359391004488	putative PBP binding loops; other site
359391004489	ABC-ATPase subunit interface; other site
359391004490	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
359391004491	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
359391004492	periplasmic dipeptide transport protein precursor KO: K02035 peptide transport system substrate-binding protein
359391004493	Bacterial extracellular solute-binding protein, family 5
359391004494	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
359391004495	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
359391004496	dimerization interface [polypeptide binding]; other site
359391004497	putative DNA binding site [nucleotide binding]; other site
359391004498	putative Zn2+ binding site [ion binding]; other site
359391004499	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
359391004500	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
359391004501	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
359391004502	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
359391004503	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
359391004504	Ligand Binding Site [chemical binding]; other site
359391004505	Protein of unknown function (DUF1153); Region: DUF1153; pfam06627
359391004506	Predicted acetyltransferase [General function prediction only]; Region: COG2388
359391004507	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
359391004508	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5400
359391004509	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5385
359391004510	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
359391004511	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
359391004512	active site
359391004513	phosphorylation site [posttranslational modification]
359391004514	intermolecular recognition site; other site
359391004515	dimerization interface [polypeptide binding]; other site
359391004516	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
359391004517	DNA binding site [nucleotide binding]
359391004518	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
359391004519	inhibitor-cofactor binding pocket; inhibition site
359391004520	pyridoxal 5'-phosphate binding site [chemical binding]; other site
359391004521	catalytic residue [active]
359391004522	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
359391004523	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
359391004524	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
359391004525	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
359391004526	PAS domain; Region: PAS_8; pfam13188
359391004527	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
359391004528	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
359391004529	putative active site [active]
359391004530	heme pocket [chemical binding]; other site
359391004531	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
359391004532	dimer interface [polypeptide binding]; other site
359391004533	phosphorylation site [posttranslational modification]
359391004534	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
359391004535	ATP binding site [chemical binding]; other site
359391004536	Mg2+ binding site [ion binding]; other site
359391004537	G-X-G motif; other site
359391004538	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
359391004539	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
359391004540	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
359391004541	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391004542	dimer interface [polypeptide binding]; other site
359391004543	conserved gate region; other site
359391004544	putative PBP binding loops; other site
359391004545	ABC-ATPase subunit interface; other site
359391004546	putrescine transport system permease protein PotH KO: K02054 spermidine/putrescine transport system permease protein
359391004547	Binding-protein-dependent transport systems inner membrane component
359391004548	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
359391004549	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
359391004550	Walker A/P-loop; other site
359391004551	ATP binding site [chemical binding]; other site
359391004552	Q-loop/lid; other site
359391004553	ABC transporter signature motif; other site
359391004554	Walker B; other site
359391004555	D-loop; other site
359391004556	H-loop/switch region; other site
359391004557	TOBE domain; Region: TOBE_2; pfam08402
359391004558	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
359391004559	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
359391004560	transcriptional regulator, Cro/CI family
359391004561	transcriptional regulator, Cro/CI family
359391004562	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
359391004563	tetramer interface [polypeptide binding]; other site
359391004564	active site
359391004565	Mg2+/Mn2+ binding site [ion binding]; other site
359391004566	7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113
359391004567	7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365
359391004568	NAD binding site [chemical binding]; other site
359391004569	substrate binding site [chemical binding]; other site
359391004570	homotetramer interface [polypeptide binding]; other site
359391004571	homodimer interface [polypeptide binding]; other site
359391004572	active site
359391004573	7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113
359391004574	7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365
359391004575	NAD binding site [chemical binding]; other site
359391004576	substrate binding site [chemical binding]; other site
359391004577	homotetramer interface [polypeptide binding]; other site
359391004578	homodimer interface [polypeptide binding]; other site
359391004579	active site
359391004580	conserved domain protein
359391004581	conserved domain protein
359391004582	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
359391004583	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
359391004584	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
359391004585	active site
359391004586	nucleophile elbow; other site
359391004587	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
359391004588	Dak phosphatase domain
359391004589	Dak kinase domain
359391004590	Putative sugar-binding domain
359391004591	Dak phosphatase domain
359391004592	Dak kinase domain
359391004593	short chain dehydrogenase; Provisional; Region: PRK06841
359391004594	classical (c) SDRs; Region: SDR_c; cd05233
359391004595	NAD(P) binding site [chemical binding]; other site
359391004596	active site
359391004597	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
359391004598	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
359391004599	putative ligand binding site [chemical binding]; other site
359391004600	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
359391004601	TM-ABC transporter signature motif; other site
359391004602	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
359391004603	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
359391004604	Walker A/P-loop; other site
359391004605	ATP binding site [chemical binding]; other site
359391004606	Q-loop/lid; other site
359391004607	ABC transporter signature motif; other site
359391004608	Walker B; other site
359391004609	D-loop; other site
359391004610	H-loop/switch region; other site
359391004611	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
359391004612	Uncharacterized conserved protein [Function unknown]; Region: COG5591
359391004613	choline dehydrogenase; Validated; Region: PRK02106
359391004614	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
359391004615	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
359391004616	Transcriptional regulator [Transcription]; Region: IclR; COG1414
359391004617	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
359391004618	Bacterial transcriptional regulator; Region: IclR; pfam01614
359391004619	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
359391004620	tetramerization interface [polypeptide binding]; other site
359391004621	NAD(P) binding site [chemical binding]; other site
359391004622	catalytic residues [active]
359391004623	Predicted membrane protein [Function unknown]; Region: COG1238
359391004624	Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495
359391004625	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
359391004626	active site
359391004627	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
359391004628	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
359391004629	minor groove reading motif; other site
359391004630	helix-hairpin-helix signature motif; other site
359391004631	substrate binding pocket [chemical binding]; other site
359391004632	active site
359391004633	Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008
359391004634	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
359391004635	active site
359391004636	nucleotide binding site [chemical binding]; other site
359391004637	HIGH motif; other site
359391004638	KMSKS motif; other site
359391004639	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
359391004640	active site
359391004641	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
359391004642	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
359391004643	Coenzyme A binding pocket [chemical binding]; other site
359391004644	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
359391004645	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
359391004646	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
359391004647	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
359391004648	DNA binding residues [nucleotide binding]
359391004649	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
359391004650	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
359391004651	RNA binding surface [nucleotide binding]; other site
359391004652	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
359391004653	active site
359391004654	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
359391004655	metal binding site 2 [ion binding]; metal-binding site
359391004656	putative DNA binding helix; other site
359391004657	metal binding site 1 [ion binding]; metal-binding site
359391004658	dimer interface [polypeptide binding]; other site
359391004659	structural Zn2+ binding site [ion binding]; other site
359391004660	PAS fold; Region: PAS_4; pfam08448
359391004661	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
359391004662	HWE histidine kinase; Region: HWE_HK; pfam07536
359391004663	Small integral membrane protein [Function unknown]; Region: COG5487
359391004664	two-component response regulator; Provisional; Region: PRK09191
359391004665	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
359391004666	active site
359391004667	phosphorylation site [posttranslational modification]
359391004668	intermolecular recognition site; other site
359391004669	dimerization interface [polypeptide binding]; other site
359391004670	RNA polymerase sigma factor; Provisional; Region: PRK12516
359391004671	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
359391004672	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
359391004673	DNA binding residues [nucleotide binding]
359391004674	CHASE3 domain; Region: CHASE3; pfam05227
359391004675	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
359391004676	Histidine kinase; Region: HisKA_2; pfam07568
359391004677	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
359391004678	ATP binding site [chemical binding]; other site
359391004679	Mg2+ binding site [ion binding]; other site
359391004680	G-X-G motif; other site
359391004681	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
359391004682	PRC-barrel domain; Region: PRC; pfam05239
359391004683	PRC-barrel domain; Region: PRC; pfam05239
359391004684	tonB-system energizer ExbB; Region: exbB; TIGR02797
359391004685	TonB system transport protein ExbD, group 1; Region: ExbD_1; TIGR02803
359391004686	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
359391004687	TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352
359391004688	conserved hypothetical protein
359391004689	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
359391004690	FtsX-like permease family; Region: FtsX; pfam02687
359391004691	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
359391004692	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
359391004693	Walker A/P-loop; other site
359391004694	ATP binding site [chemical binding]; other site
359391004695	Q-loop/lid; other site
359391004696	ABC transporter signature motif; other site
359391004697	Walker B; other site
359391004698	D-loop; other site
359391004699	H-loop/switch region; other site
359391004700	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
359391004701	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
359391004702	macrolide transporter subunit MacA; Provisional; Region: PRK11578
359391004703	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
359391004704	HlyD family secretion protein; Region: HlyD_3; pfam13437
359391004705	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
359391004706	trimer interface [polypeptide binding]; other site
359391004707	active site
359391004708	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
359391004709	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
359391004710	dimerization interface [polypeptide binding]; other site
359391004711	putative DNA binding site [nucleotide binding]; other site
359391004712	putative Zn2+ binding site [ion binding]; other site
359391004713	AsnC family; Region: AsnC_trans_reg; pfam01037
359391004714	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
359391004715	putative active site [active]
359391004716	putative dimer interface [polypeptide binding]; other site
359391004717	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
359391004718	diiron binding motif [ion binding]; other site
359391004719	CCC1-related protein family; Region: CCC1_like_1; cd02437
359391004720	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
359391004721	metabolite-proton symporter; Region: 2A0106; TIGR00883
359391004722	putative substrate translocation pore; other site
359391004723	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
359391004724	GDP-binding site [chemical binding]; other site
359391004725	ACT binding site; other site
359391004726	IMP binding site; other site
359391004727	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
359391004728	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
359391004729	Coenzyme A binding pocket [chemical binding]; other site
359391004730	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
359391004731	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
359391004732	ligand binding site [chemical binding]; other site
359391004733	NAD binding site [chemical binding]; other site
359391004734	dimerization interface [polypeptide binding]; other site
359391004735	catalytic site [active]
359391004736	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
359391004737	putative L-serine binding site [chemical binding]; other site
359391004738	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
359391004739	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
359391004740	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
359391004741	catalytic residue [active]
359391004742	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
359391004743	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
359391004744	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315
359391004745	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
359391004746	active site
359391004747	substrate binding site [chemical binding]; other site
359391004748	metal binding site [ion binding]; metal-binding site
359391004749	FtsH Extracellular; Region: FtsH_ext; pfam06480
359391004750	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
359391004751	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
359391004752	Walker A motif; other site
359391004753	ATP binding site [chemical binding]; other site
359391004754	Walker B motif; other site
359391004755	arginine finger; other site
359391004756	Peptidase family M41; Region: Peptidase_M41; pfam01434
359391004757	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
359391004758	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
359391004759	Ligand Binding Site [chemical binding]; other site
359391004760	NNMT/PNMT/TEMT family; Region: NNMT_PNMT_TEMT; pfam01234
359391004761	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729
359391004762	Tetratricopeptide repeat; Region: TPR_6; pfam13174
359391004763	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
359391004764	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
359391004765	ligand binding site [chemical binding]; other site
359391004766	translocation protein TolB; Provisional; Region: tolB; PRK05137
359391004767	TolB amino-terminal domain; Region: TolB_N; pfam04052
359391004768	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
359391004769	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
359391004770	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
359391004771	TolQ protein; Region: tolQ; TIGR02796
359391004772	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
359391004773	active site
359391004774	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
359391004775	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
359391004776	Walker A motif; other site
359391004777	ATP binding site [chemical binding]; other site
359391004778	Walker B motif; other site
359391004779	arginine finger; other site
359391004780	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
359391004781	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
359391004782	RuvA N terminal domain; Region: RuvA_N; pfam01330
359391004783	Helix-hairpin-helix domain; Region: HHH_5; pfam14520
359391004784	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
359391004785	active site
359391004786	putative DNA-binding cleft [nucleotide binding]; other site
359391004787	dimer interface [polypeptide binding]; other site
359391004788	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5317
359391004789	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4645
359391004790	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
359391004791	thiamine phosphate binding site [chemical binding]; other site
359391004792	active site
359391004793	pyrophosphate binding site [ion binding]; other site
359391004794	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
359391004795	Sel1-like repeats; Region: SEL1; smart00671
359391004796	Sel1-like repeats; Region: SEL1; smart00671
359391004797	elongation factor P; Validated; Region: PRK00529
359391004798	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
359391004799	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
359391004800	RNA binding site [nucleotide binding]; other site
359391004801	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
359391004802	RNA binding site [nucleotide binding]; other site
359391004803	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
359391004804	active site
359391004805	dimerization interface [polypeptide binding]; other site
359391004806	hypothetical protein; Validated; Region: PRK09039
359391004807	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
359391004808	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
359391004809	ligand binding site [chemical binding]; other site
359391004810	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
359391004811	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
359391004812	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
359391004813	Walker A/P-loop; other site
359391004814	ATP binding site [chemical binding]; other site
359391004815	Q-loop/lid; other site
359391004816	ABC transporter signature motif; other site
359391004817	Walker B; other site
359391004818	D-loop; other site
359391004819	H-loop/switch region; other site
359391004820	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528
359391004821	hypothetical protein; Validated; Region: PRK00110
359391004822	Transcriptional regulators [Transcription]; Region: GntR; COG1802
359391004823	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
359391004824	DNA-binding site [nucleotide binding]; DNA binding site
359391004825	FCD domain; Region: FCD; pfam07729
359391004826	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
359391004827	Uncharacterized conserved protein [Function unknown]; Region: COG3543
359391004828	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
359391004829	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
359391004830	putative active site [active]
359391004831	metal binding site [ion binding]; metal-binding site
359391004832	homodimer binding site [polypeptide binding]; other site
359391004833	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
359391004834	Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division,    chromosome partitioning]; Region: zapA; COG3027
359391004835	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
359391004836	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
359391004837	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
359391004838	TPP-binding site [chemical binding]; other site
359391004839	dimer interface [polypeptide binding]; other site
359391004840	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
359391004841	PYR/PP interface [polypeptide binding]; other site
359391004842	dimer interface [polypeptide binding]; other site
359391004843	TPP binding site [chemical binding]; other site
359391004844	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
359391004845	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
359391004846	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
359391004847	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
359391004848	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
359391004849	substrate binding site [chemical binding]; other site
359391004850	hinge regions; other site
359391004851	ADP binding site [chemical binding]; other site
359391004852	catalytic site [active]
359391004853	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
359391004854	Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967
359391004855	acyl-activating enzyme (AAE) consensus motif; other site
359391004856	putative AMP binding site [chemical binding]; other site
359391004857	putative active site [active]
359391004858	putative CoA binding site [chemical binding]; other site
359391004859	classical (c) SDRs; Region: SDR_c; cd05233
359391004860	Predicted transcriptional regulator [Transcription]; Region: COG2378
359391004861	HTH domain; Region: HTH_11; pfam08279
359391004862	WYL domain; Region: WYL; pfam13280
359391004863	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
359391004864	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
359391004865	CoenzymeA binding site [chemical binding]; other site
359391004866	subunit interaction site [polypeptide binding]; other site
359391004867	PHB binding site; other site
359391004868	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820
359391004869	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
359391004870	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
359391004871	NAD(P) binding site [chemical binding]; other site
359391004872	Uncharacterized small protein containing a coiled-coil domain [Function unknown]; Region: COG5509
359391004873	transporter, putative
359391004874	Major facilitator superfamily (MFS)
359391004875	Uncharacterized small protein [Function unknown]; Region: COG5570
359391004876	Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481
359391004877	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
359391004878	phosphoribosylaminoimidazole carboxylase, PurK protein; Region: purK; TIGR01161
359391004879	ATP-grasp domain; Region: ATP-grasp_4; cl17255
359391004880	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
359391004881	TPR repeat; Region: TPR_11; pfam13414
359391004882	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
359391004883	TPR motif; other site
359391004884	binding surface
359391004885	pyruvate kinase; Provisional; Region: PRK06247
359391004886	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288
359391004887	domain interfaces; other site
359391004888	active site
359391004889	Predicted integral membrane protein [Function unknown]; Region: COG5480
359391004890	Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931
359391004891	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3750
359391004892	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
359391004893	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
359391004894	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
359391004896	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
359391004897	Thiamine pyrophosphokinase; Region: TPK; cd07995
359391004898	active site
359391004899	dimerization interface [polypeptide binding]; other site
359391004900	thiamine binding site [chemical binding]; other site
359391004901	thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205
359391004902	thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433
359391004903	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391004904	dimer interface [polypeptide binding]; other site
359391004905	conserved gate region; other site
359391004906	putative PBP binding loops; other site
359391004907	ABC-ATPase subunit interface; other site
359391004908	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391004909	dimer interface [polypeptide binding]; other site
359391004910	conserved gate region; other site
359391004911	putative PBP binding loops; other site
359391004912	ABC-ATPase subunit interface; other site
359391004913	ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840
359391004914	ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298
359391004915	Walker A/P-loop; other site
359391004916	ATP binding site [chemical binding]; other site
359391004917	Q-loop/lid; other site
359391004918	ABC transporter signature motif; other site
359391004919	Walker B; other site
359391004920	D-loop; other site
359391004921	H-loop/switch region; other site
359391004922	Putative Zn-dependent protease [General function prediction only]; Region: COG4784
359391004923	Peptidase family M48; Region: Peptidase_M48; pfam01435
359391004924	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
359391004925	MOSC domain; Region: MOSC; pfam03473
359391004926	3-alpha domain; Region: 3-alpha; pfam03475
359391004927	RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500
359391004928	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
359391004929	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
359391004930	DNA binding residues [nucleotide binding]
359391004931	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
359391004932	Ferredoxin [Energy production and conversion]; Region: COG1146
359391004933	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
359391004934	4Fe-4S binding domain; Region: Fer4; pfam00037
359391004935	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
359391004936	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
359391004937	RNA binding surface [nucleotide binding]; other site
359391004938	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
359391004939	ATP binding site [chemical binding]; other site
359391004940	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
359391004941	putative Mg++ binding site [ion binding]; other site
359391004942	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
359391004943	nucleotide binding region [chemical binding]; other site
359391004944	ATP-binding site [chemical binding]; other site
359391004945	mRNA cap methylation, RNMT-activating mini protein; Region: RAM; pfam15320
359391004946	putative acyltransferase; Provisional; Region: PRK05790
359391004947	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
359391004948	dimer interface [polypeptide binding]; other site
359391004949	active site
359391004950	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
359391004951	Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333
359391004952	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
359391004953	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
359391004954	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
359391004955	substrate binding pocket [chemical binding]; other site
359391004956	chain length determination region; other site
359391004957	active site lid residues [active]
359391004958	substrate-Mg2+ binding site; other site
359391004959	catalytic residues [active]
359391004960	aspartate-rich region 1; other site
359391004961	aspartate-rich region 2; other site
359391004962	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
359391004963	1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612
359391004964	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
359391004965	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
359391004966	NAD(P) binding site [chemical binding]; other site
359391004967	active site
359391004968	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
359391004969	Major Facilitator Superfamily; Region: MFS_1; pfam07690
359391004970	putative substrate translocation pore; other site
359391004971	Pyruvate carboxylase [Energy production and conversion]; Region: PycA; COG1038
359391004972	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
359391004973	ATP-grasp domain; Region: ATP-grasp_4; cl17255
359391004974	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
359391004975	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
359391004976	active site
359391004977	catalytic residues [active]
359391004978	metal binding site [ion binding]; metal-binding site
359391004979	homodimer binding site [polypeptide binding]; other site
359391004980	Conserved carboxylase domain; Region: PYC_OADA; pfam02436
359391004981	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
359391004982	carboxyltransferase (CT) interaction site; other site
359391004983	biotinylation site [posttranslational modification]; other site
359391004984	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
359391004985	dimerization interface [polypeptide binding]; other site
359391004986	Receptor family ligand binding region; Region: ANF_receptor; pfam01094
359391004987	ligand binding site [chemical binding]; other site
359391004988	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
359391004989	dimerization interface [polypeptide binding]; other site
359391004990	Receptor family ligand binding region; Region: ANF_receptor; pfam01094
359391004991	ligand binding site [chemical binding]; other site
359391004992	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
359391004993	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
359391004994	Walker A/P-loop; other site
359391004995	ATP binding site [chemical binding]; other site
359391004996	Q-loop/lid; other site
359391004997	ABC transporter signature motif; other site
359391004998	Walker B; other site
359391004999	D-loop; other site
359391005000	H-loop/switch region; other site
359391005001	ATP/GTP-binding site motif A (P-loop):ABC transporter:AAA ATPase
359391005002	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
359391005003	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
359391005004	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
359391005005	TM-ABC transporter signature motif; other site
359391005006	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
359391005007	TM-ABC transporter signature motif; other site
359391005008	Proline racemase [Amino acid transport and metabolism]; Region: COG3938
359391005009	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
359391005010	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
359391005011	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
359391005012	Transcriptional regulators [Transcription]; Region: FadR; COG2186
359391005013	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
359391005014	DNA-binding site [nucleotide binding]; DNA binding site
359391005015	FCD domain; Region: FCD; pfam07729
359391005016	Transcriptional regulators [Transcription]; Region: MarR; COG1846
359391005017	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
359391005018	F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]; Region: AtpC; COG0355
359391005019	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
359391005020	gamma subunit interface [polypeptide binding]; other site
359391005021	epsilon subunit interface [polypeptide binding]; other site
359391005022	LBP interface [polypeptide binding]; other site
359391005023	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
359391005024	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
359391005025	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
359391005026	alpha subunit interaction interface [polypeptide binding]; other site
359391005027	Walker A motif; other site
359391005028	ATP binding site [chemical binding]; other site
359391005029	Walker B motif; other site
359391005030	inhibitor binding site; inhibition site
359391005031	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
359391005032	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
359391005033	core domain interface [polypeptide binding]; other site
359391005034	delta subunit interface [polypeptide binding]; other site
359391005035	epsilon subunit interface [polypeptide binding]; other site
359391005036	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
359391005037	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
359391005038	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
359391005039	beta subunit interaction interface [polypeptide binding]; other site
359391005040	Walker A motif; other site
359391005041	ATP binding site [chemical binding]; other site
359391005042	Walker B motif; other site
359391005043	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
359391005044	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
359391005045	primosome assembly protein PriA; Validated; Region: PRK05580
359391005046	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
359391005047	ATP binding site [chemical binding]; other site
359391005048	putative Mg++ binding site [ion binding]; other site
359391005049	helicase superfamily c-terminal domain; Region: HELICc; smart00490
359391005050	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
359391005051	active site
359391005052	intersubunit interactions; other site
359391005053	catalytic residue [active]
359391005054	Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5468
359391005055	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
359391005056	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
359391005057	active site
359391005058	HIGH motif; other site
359391005059	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
359391005060	KMSKS motif; other site
359391005061	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
359391005062	tRNA binding surface [nucleotide binding]; other site
359391005063	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
359391005064	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
359391005065	catalytic residue [active]
359391005066	Predicted membrane protein [Function unknown]; Region: COG1289
359391005067	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
359391005068	Usg protein, probable subunit of phosphoribosylanthranilate isomerase [Amino acid transport and metabolism]; Region: COG5425
359391005069	acetyl-CoA synthetase; Provisional; Region: PRK00174
359391005070	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
359391005071	active site
359391005072	CoA binding site [chemical binding]; other site
359391005073	acyl-activating enzyme (AAE) consensus motif; other site
359391005074	AMP binding site [chemical binding]; other site
359391005075	acetate binding site [chemical binding]; other site
359391005076	Uncharacterized conserved small protein [Function unknown]; Region: COG5508
359391005077	Protein of unknown function (DUF1674); Region: DUF1674; pfam07896
359391005078	heat shock protein HtpX; Provisional; Region: PRK01345
359391005079	M48 family peptidase; Provisional; Region: PRK03001
359391005080	NusB family; Region: NusB; pfam01029
359391005081	putative RNA binding site [nucleotide binding]; other site
359391005082	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
359391005083	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
359391005084	S-adenosylmethionine binding site [chemical binding]; other site
359391005085	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5360
359391005086	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
359391005087	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
359391005088	purine monophosphate binding site [chemical binding]; other site
359391005089	dimer interface [polypeptide binding]; other site
359391005090	putative catalytic residues [active]
359391005091	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
359391005092	membrane protein, putative
359391005093	transporter
359391005094	NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902
359391005095	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
359391005096	Predicted membrane protein [Function unknown]; Region: COG3762
359391005097	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
359391005098	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
359391005099	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
359391005100	chorismate mutase; Provisional; Region: PRK09239
359391005101	signal recognition particle protein; Provisional; Region: PRK10867
359391005102	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
359391005103	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
359391005104	P loop; other site
359391005105	GTP binding site [chemical binding]; other site
359391005106	Signal peptide binding domain; Region: SRP_SPB; pfam02978
359391005107	lytic murein transglycosylase; Region: MltB_2; TIGR02283
359391005108	Transglycosylase SLT domain; Region: SLT_2; pfam13406
359391005109	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
359391005110	active site clefts [active]
359391005111	zinc binding site [ion binding]; other site
359391005112	dimer interface [polypeptide binding]; other site
359391005113	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
359391005114	dimer interface [polypeptide binding]; other site
359391005115	pyridoxal binding site [chemical binding]; other site
359391005116	ATP binding site [chemical binding]; other site
359391005117	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
359391005118	tetrameric interface [polypeptide binding]; other site
359391005119	NAD binding site [chemical binding]; other site
359391005120	catalytic residues [active]
359391005121	Transcriptional regulator [Transcription]; Region: LysR; COG0583
359391005122	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
359391005123	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
359391005124	dimerization interface [polypeptide binding]; other site
359391005125	Predicted membrane protein [Function unknown]; Region: COG3619
359391005126	Predicted membrane protein [Function unknown]; Region: COG2261
359391005127	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
359391005128	putative active site [active]
359391005129	Ap4A binding site [chemical binding]; other site
359391005130	nudix motif; other site
359391005131	putative metal binding site [ion binding]; other site
359391005132	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
359391005133	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
359391005134	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
359391005135	protein binding site [polypeptide binding]; other site
359391005136	Catalytic dyad [active]
359391005137	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
359391005138	COG (conserved oligomeric Golgi) complex component, COG2; Region: COG2; cl19297
359391005139	Peptidase family M23; Region: Peptidase_M23; pfam01551
359391005140	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
359391005141	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
359391005142	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
359391005143	active site
359391005144	(T/H)XGH motif; other site
359391005145	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
359391005146	putative catalytic cysteine [active]
359391005147	gamma-glutamyl kinase; Provisional; Region: PRK05429
359391005148	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
359391005149	nucleotide binding site [chemical binding]; other site
359391005150	homotetrameric interface [polypeptide binding]; other site
359391005151	putative phosphate binding site [ion binding]; other site
359391005152	putative allosteric binding site; other site
359391005153	PUA domain; Region: PUA; pfam01472
359391005154	GTPase CgtA; Reviewed; Region: obgE; PRK12299
359391005155	GTP1/OBG; Region: GTP1_OBG; pfam01018
359391005156	Obg GTPase; Region: Obg; cd01898
359391005157	G1 box; other site
359391005158	GTP/Mg2+ binding site [chemical binding]; other site
359391005159	Switch I region; other site
359391005160	G2 box; other site
359391005161	G3 box; other site
359391005162	Switch II region; other site
359391005163	G4 box; other site
359391005164	G5 box; other site
359391005165	YadA-like C-terminal region; Region: YadA_anchor; pfam03895
359391005166	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
359391005167	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
359391005168	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
359391005169	Coenzyme A binding pocket [chemical binding]; other site
359391005170	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
359391005171	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
359391005172	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
359391005173	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
359391005174	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
359391005175	Integrase core domain; Region: rve; pfam00665
359391005176	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
359391005177	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
359391005178	non-specific DNA binding site [nucleotide binding]; other site
359391005179	salt bridge; other site
359391005180	sequence-specific DNA binding site [nucleotide binding]; other site
359391005181	Methyltransferase domain; Region: Methyltransf_31; pfam13847
359391005182	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
359391005183	S-adenosylmethionine binding site [chemical binding]; other site
359391005184	AzlC protein; Region: AzlC; pfam03591
359391005185	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
359391005186	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
359391005187	Integrase core domain; Region: rve; pfam00665
359391005188	aminopeptidase N, Escherichia coli type; Region: pepN_proteo; TIGR02414
359391005189	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
359391005190	Peptidase family M23; Region: Peptidase_M23; pfam01551
359391005191	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
359391005192	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
359391005193	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
359391005194	Clp amino terminal domain; Region: Clp_N; pfam02861
359391005195	Clp amino terminal domain; Region: Clp_N; pfam02861
359391005196	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
359391005197	Walker A motif; other site
359391005198	ATP binding site [chemical binding]; other site
359391005199	Walker B motif; other site
359391005200	arginine finger; other site
359391005201	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
359391005202	Walker A motif; other site
359391005203	ATP binding site [chemical binding]; other site
359391005204	Walker B motif; other site
359391005205	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
359391005206	Domain of unknown function (DUF4167); Region: DUF4167; pfam13763
359391005207	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
359391005208	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
359391005209	S-adenosylmethionine binding site [chemical binding]; other site
359391005210	peptide chain release factor 1; Validated; Region: prfA; PRK00591
359391005211	This domain is found in peptide chain release factors; Region: PCRF; smart00937
359391005212	RF-1 domain; Region: RF-1; pfam00472
359391005213	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
359391005214	GAF domain; Region: GAF; pfam01590
359391005215	PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524
359391005216	PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391
359391005217	PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
359391005218	aspartate kinase; Reviewed; Region: PRK06635
359391005219	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
359391005220	putative nucleotide binding site [chemical binding]; other site
359391005221	putative catalytic residues [active]
359391005222	putative Mg ion binding site [ion binding]; other site
359391005223	putative aspartate binding site [chemical binding]; other site
359391005224	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
359391005225	putative allosteric regulatory site; other site
359391005226	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923
359391005227	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
359391005228	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
359391005229	S-adenosylmethionine binding site [chemical binding]; other site
359391005230	Protein of unknown function DUF6
359391005231	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5319
359391005232	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
359391005233	putative active site [active]
359391005234	catalytic triad [active]
359391005235	dimer interface [polypeptide binding]; other site
359391005236	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
359391005237	GSH binding site [chemical binding]; other site
359391005238	catalytic residues [active]
359391005239	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
359391005240	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
359391005241	active site
359391005242	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
359391005243	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
359391005244	H+ Antiporter protein; Region: 2A0121; TIGR00900
359391005245	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
359391005246	putative substrate translocation pore; other site
359391005247	conserved hypothetical protein
359391005248	Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898
359391005249	HemY protein N-terminus; Region: HemY_N; pfam07219
359391005250	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223
359391005251	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
359391005252	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
359391005253	active site
359391005254	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
359391005255	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
359391005256	domain interfaces; other site
359391005257	active site
359391005258	UGMP family protein; Validated; Region: PRK09604
359391005259	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
359391005260	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240
359391005261	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
359391005262	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
359391005263	YCII-related domain; Region: YCII; cl00999
359391005264	Uncharacterized conserved protein [Function unknown]; Region: COG2947
359391005265	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
359391005266	S-adenosylmethionine binding site [chemical binding]; other site
359391005267	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
359391005268	EamA-like transporter family; Region: EamA; pfam00892
359391005269	EamA-like transporter family; Region: EamA; pfam00892
359391005270	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
359391005271	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
359391005272	DNA-binding site [nucleotide binding]; DNA binding site
359391005273	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
359391005274	pyridoxal 5'-phosphate binding site [chemical binding]; other site
359391005275	homodimer interface [polypeptide binding]; other site
359391005276	catalytic residue [active]
359391005277	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
359391005278	AAA-like domain; Region: AAA_10; pfam12846
359391005279	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
359391005280	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
359391005281	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
359391005282	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
359391005283	active site
359391005284	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
359391005285	catalytic triad [active]
359391005286	dimer interface [polypeptide binding]; other site
359391005287	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333
359391005288	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
359391005289	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
359391005290	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
359391005291	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
359391005292	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
359391005293	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
359391005294	L-aspartate oxidase; Provisional; Region: PRK06175
359391005295	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
359391005296	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495
359391005297	putative SdhC subunit interface [polypeptide binding]; other site
359391005298	putative proximal heme binding site [chemical binding]; other site
359391005299	putative Iron-sulfur protein interface [polypeptide binding]; other site
359391005300	putative proximal quinone binding site; other site
359391005301	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
359391005302	Iron-sulfur protein interface; other site
359391005303	proximal quinone binding site [chemical binding]; other site
359391005304	SdhD (CybS) interface [polypeptide binding]; other site
359391005305	proximal heme binding site [chemical binding]; other site
359391005306	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
359391005307	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
359391005308	Coenzyme A binding pocket [chemical binding]; other site
359391005309	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
359391005310	substrate binding site [chemical binding]; other site
359391005311	ligand binding site [chemical binding]; other site
359391005312	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
359391005313	Permease for cytosine/purines, uracil, thiamine, allantoin
359391005314	Permease for cytosine/purines, uracil, thiamine, allantoin
359391005315	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116
359391005316	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
359391005317	NIPSNAP; Region: NIPSNAP; pfam07978
359391005318	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
359391005319	dimerization interface [polypeptide binding]; other site
359391005320	putative DNA binding site [nucleotide binding]; other site
359391005321	putative Zn2+ binding site [ion binding]; other site
359391005322	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
359391005323	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
359391005324	RimM N-terminal domain; Region: RimM; pfam01782
359391005325	PRC-barrel domain; Region: PRC; pfam05239
359391005326	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
359391005327	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
359391005328	active site
359391005329	DNA binding site [nucleotide binding]
359391005330	Int/Topo IB signature motif; other site
359391005331	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735
359391005332	dihydrolipoamide dehydrogenase; Validated; Region: PRK06292
359391005333	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
359391005334	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
359391005335	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
359391005336	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
359391005337	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
359391005338	Predicted membrane protein [Function unknown]; Region: COG3686
359391005339	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
359391005340	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
359391005341	E3 interaction surface; other site
359391005342	lipoyl attachment site [posttranslational modification]; other site
359391005343	e3 binding domain; Region: E3_binding; pfam02817
359391005344	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
359391005345	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
359391005346	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
359391005347	TPP-binding site [chemical binding]; other site
359391005348	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
359391005349	SPTR top hit: 'Q8FYF6 Hypothetical protein. Brucella suis., evalue=6e-10, 96% identity hit'; KEGG top hit: 'bms:BR1924 category=Unassigned, evalue=4e-10, 96.551724% identity hit';hypothetical
359391005350	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
359391005351	CoA binding domain; Region: CoA_binding; smart00881
359391005352	CoA-ligase; Region: Ligase_CoA; pfam00549
359391005353	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
359391005354	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
359391005355	CoA-ligase; Region: Ligase_CoA; pfam00549
359391005356	malate dehydrogenase; Reviewed; Region: PRK06223
359391005357	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
359391005358	NAD(P) binding site [chemical binding]; other site
359391005359	dimer interface [polypeptide binding]; other site
359391005360	tetramer (dimer of dimers) interface [polypeptide binding]; other site
359391005361	substrate binding site [chemical binding]; other site
359391005362	Predicted ATPase [General function prediction only]; Region: COG1485
359391005363	Protease inhibitor Inh; Region: Inh; pfam02974
359391005364	Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253
359391005365	Diaminopimelate epimerase; Region: DAP_epimerase; cl19724
359391005366	Diaminopimelate epimerase; Region: DAP_epimerase; cl19724
359391005367	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
359391005368	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
359391005369	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
359391005370	FeS/SAM binding site; other site
359391005371	Mitochondria Localisation Sequence; Region: AIF-MLS; pfam14962
359391005372	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
359391005373	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
359391005374	SRP54-type protein, GTPase domain; Region: SRP54; smart00962
359391005375	intracellular septation protein A; Reviewed; Region: PRK00259
359391005376	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
359391005377	conserved hypothetical protein
359391005378	conserved hypothetical protein
359391005379	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
359391005380	active site
359391005381	8-oxo-dGMP binding site [chemical binding]; other site
359391005382	nudix motif; other site
359391005383	metal binding site [ion binding]; metal-binding site
359391005384	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
359391005385	Coenzyme A binding pocket [chemical binding]; other site
359391005386	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
359391005387	heterotetramer interface [polypeptide binding]; other site
359391005388	active site pocket [active]
359391005389	cleavage site
359391005390	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
359391005391	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
359391005392	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
359391005393	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
359391005394	ATP binding site [chemical binding]; other site
359391005395	putative Mg++ binding site [ion binding]; other site
359391005396	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
359391005397	SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516
359391005398	SEC-C motif; Region: SEC-C; pfam02810
359391005399	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
359391005400	membrane protein, putative
359391005401	Sulfatase
359391005402	Transcriptional regulator [Transcription]; Region: LysR; COG0583
359391005403	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
359391005404	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
359391005405	dimerization interface [polypeptide binding]; other site
359391005406	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
359391005407	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
359391005408	substrate binding pocket [chemical binding]; other site
359391005409	membrane-bound complex binding site; other site
359391005410	hinge residues; other site
359391005411	Binding-protein-dependent transport systems inner membrane component
359391005412	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
359391005413	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391005414	dimer interface [polypeptide binding]; other site
359391005415	conserved gate region; other site
359391005416	putative PBP binding loops; other site
359391005417	ABC-ATPase subunit interface; other site
359391005418	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
359391005419	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
359391005420	Walker A/P-loop; other site
359391005421	ATP binding site [chemical binding]; other site
359391005422	Q-loop/lid; other site
359391005423	ABC transporter signature motif; other site
359391005424	Walker B; other site
359391005425	D-loop; other site
359391005426	H-loop/switch region; other site
359391005427	Agmatinase and related proteins; Region: Agmatinase_like_1; cd11589
359391005428	oligomer interface [polypeptide binding]; other site
359391005429	active site
359391005430	Mn binding site [ion binding]; other site
359391005431	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
359391005432	Aspartase; Region: Aspartase; cd01357
359391005433	active sites [active]
359391005434	tetramer interface [polypeptide binding]; other site
359391005435	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
359391005436	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
359391005437	Walker A/P-loop; other site
359391005438	ATP binding site [chemical binding]; other site
359391005439	Q-loop/lid; other site
359391005440	ABC transporter signature motif; other site
359391005441	Walker B; other site
359391005442	D-loop; other site
359391005443	H-loop/switch region; other site
359391005444	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
359391005445	active site
359391005446	homotetramer interface [polypeptide binding]; other site
359391005447	homodimer interface [polypeptide binding]; other site
359391005448	Transcriptional regulators [Transcription]; Region: GntR; COG1802
359391005449	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
359391005450	DNA-binding site [nucleotide binding]; DNA binding site
359391005451	FCD domain; Region: FCD; pfam07729
359391005452	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
359391005453	active site
359391005454	homotetramer interface [polypeptide binding]; other site
359391005455	homodimer interface [polypeptide binding]; other site
359391005456	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
359391005457	D-galactonate transporter; Region: 2A0114; TIGR00893
359391005458	putative substrate translocation pore; other site
359391005459	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
359391005460	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
359391005461	homodimer interface [polypeptide binding]; other site
359391005462	substrate-cofactor binding pocket; other site
359391005463	pyridoxal 5'-phosphate binding site [chemical binding]; other site
359391005464	catalytic residue [active]
359391005465	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
359391005466	Ligand Binding Site [chemical binding]; other site
359391005467	cysteine synthase; Region: PLN02565
359391005468	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
359391005469	dimer interface [polypeptide binding]; other site
359391005470	pyridoxal 5'-phosphate binding site [chemical binding]; other site
359391005471	catalytic residue [active]
359391005472	conserved hypothetical protein
359391005473	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530
359391005474	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
359391005475	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
359391005476	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
359391005477	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
359391005478	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
359391005479	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
359391005480	Ligand binding site [chemical binding]; other site
359391005481	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
359391005482	Ligand Binding Site [chemical binding]; other site
359391005483	6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720
359391005484	active site
359391005485	7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365
359391005486	4Fe-4S single cluster domain; Region: Fer4_14; pfam13394
359391005487	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
359391005488	Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588
359391005489	short chain dehydrogenase; Validated; Region: PRK06182
359391005490	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
359391005491	NADP binding site [chemical binding]; other site
359391005492	active site
359391005493	steroid binding site; other site
359391005494	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
359391005495	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671
359391005496	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
359391005497	catalytic residues [active]
359391005498	argininosuccinate lyase; Provisional; Region: PRK00855
359391005499	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
359391005500	active sites [active]
359391005501	tetramer interface [polypeptide binding]; other site
359391005502	Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567
359391005503	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
359391005504	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
359391005505	active site
359391005506	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
359391005507	substrate binding site [chemical binding]; other site
359391005508	catalytic residues [active]
359391005509	dimer interface [polypeptide binding]; other site
359391005510	TIGR02302 family protein; Region: aProt_lowcomp
359391005511	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
359391005512	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
359391005513	active site
359391005514	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
359391005515	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
359391005516	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
359391005517	pyridoxal 5'-phosphate binding site [chemical binding]; other site
359391005518	homodimer interface [polypeptide binding]; other site
359391005519	catalytic residue [active]
359391005520	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
359391005521	prephenate dehydrogenase; Validated; Region: PRK08507
359391005522	Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703
359391005523	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
359391005524	putative active site pocket [active]
359391005525	dimerization interface [polypeptide binding]; other site
359391005526	putative catalytic residue [active]
359391005527	YGGT family; Region: YGGT; pfam02325
359391005528	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
359391005529	dimer interface [polypeptide binding]; other site
359391005530	substrate binding site [chemical binding]; other site
359391005531	metal binding sites [ion binding]; metal-binding site
359391005532	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
359391005533	putative acyl-acceptor binding pocket; other site
359391005534	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
359391005535	putative active site [active]
359391005536	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
359391005537	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
359391005538	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
359391005539	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
359391005540	Walker A/P-loop; other site
359391005541	ATP binding site [chemical binding]; other site
359391005542	Q-loop/lid; other site
359391005543	ABC transporter signature motif; other site
359391005544	Walker B; other site
359391005545	D-loop; other site
359391005546	H-loop/switch region; other site
359391005547	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
359391005548	amphipathic channel; other site
359391005549	Asn-Pro-Ala signature motifs; other site
359391005550	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
359391005551	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
359391005552	putative catalytic site [active]
359391005553	putative phosphate binding site [ion binding]; other site
359391005554	active site
359391005555	metal binding site A [ion binding]; metal-binding site
359391005556	DNA binding site [nucleotide binding]
359391005557	putative AP binding site [nucleotide binding]; other site
359391005558	putative metal binding site B [ion binding]; other site
359391005559	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
359391005560	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
359391005561	ligand binding site [chemical binding]; other site
359391005562	Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; cl19511
359391005563	flexible hinge region; other site
359391005564	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
359391005565	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
359391005566	active site
359391005567	phosphorylation site [posttranslational modification]
359391005568	intermolecular recognition site; other site
359391005569	dimerization interface [polypeptide binding]; other site
359391005570	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
359391005571	DNA binding site [nucleotide binding]
359391005572	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
359391005573	intimin/invasin family protein
359391005575	Autotransporter beta-domain:Outer membrane autotransporter barrel
359391005576	Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738
359391005577	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
359391005578	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
359391005579	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
359391005580	DNA binding residues [nucleotide binding]
359391005581	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
359391005582	dimer interface [polypeptide binding]; other site
359391005583	putative metal binding site [ion binding]; other site
359391005584	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
359391005585	metal-binding site [ion binding]
359391005586	zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033
359391005587	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
359391005588	metal-binding site [ion binding]
359391005589	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
359391005590	Soluble P-type ATPase [General function prediction only]; Region: COG4087
359391005591	Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase) [Coenzyme metabolism]; Region: CobT; COG4547
359391005592	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
359391005593	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
359391005594	metal ion-dependent adhesion site (MIDAS); other site
359391005595	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
359391005596	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
359391005597	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944
359391005598	DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214
359391005599	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
359391005600	HSP70 interaction site [polypeptide binding]; other site
359391005601	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
359391005602	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
359391005603	Domain of unknown function DUF21; Region: DUF21; pfam01595
359391005604	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
359391005605	Transporter associated domain; Region: CorC_HlyC; smart01091
359391005606	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
359391005607	active site
359391005608	dimer interface [polypeptide binding]; other site
359391005609	metal binding site [ion binding]; metal-binding site
359391005610	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
359391005611	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
359391005612	ADP binding site [chemical binding]; other site
359391005613	magnesium binding site [ion binding]; other site
359391005614	putative shikimate binding site; other site
359391005615	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
359391005616	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
359391005617	active site
359391005618	DNA binding site [nucleotide binding]
359391005619	Int/Topo IB signature motif; other site
359391005620	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
359391005621	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
359391005622	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
359391005623	CPxP  motif; other site
359391005624	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
359391005625	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
359391005626	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
359391005627	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
359391005628	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191
359391005629	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
359391005630	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
359391005631	metal binding site [ion binding]; metal-binding site
359391005632	putative dimer interface [polypeptide binding]; other site
359391005633	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
359391005634	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
359391005635	NAD(P) binding site [chemical binding]; other site
359391005636	active site
359391005637	Uncharacterized conserved protein [Function unknown]; Region: COG3791
359391005638	Domain of unknown function (DUF4354); Region: DUF4354; pfam14263
359391005639	choline dehydrogenase; Validated; Region: PRK02106
359391005640	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
359391005641	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
359391005642	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745
359391005643	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
359391005644	NAD(P) binding site [chemical binding]; other site
359391005645	active site
359391005646	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
359391005647	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
359391005648	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
359391005649	Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118
359391005650	NAD(P) binding site [chemical binding]; other site
359391005651	catalytic residues [active]
359391005652	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
359391005653	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
359391005654	substrate binding site [chemical binding]; other site
359391005655	oxyanion hole (OAH) forming residues; other site
359391005656	trimer interface [polypeptide binding]; other site
359391005658	Coenzyme A transferase
359391005659	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
359391005660	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
359391005661	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
359391005662	Transcriptional regulators [Transcription]; Region: PurR; COG1609
359391005663	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
359391005664	DNA binding site [nucleotide binding]
359391005665	domain linker motif; other site
359391005666	Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289
359391005667	putative dimerization interface [polypeptide binding]; other site
359391005668	putative ligand binding site [chemical binding]; other site
359391005669	Protein of unknown function (DUF993); Region: DUF993; pfam06187
359391005670	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
359391005671	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
359391005672	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
359391005673	zinc binding site [ion binding]; other site
359391005674	putative ligand binding site [chemical binding]; other site
359391005675	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
359391005676	TM-ABC transporter signature motif; other site
359391005677	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
359391005678	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
359391005679	Walker A/P-loop; other site
359391005680	ATP binding site [chemical binding]; other site
359391005681	Q-loop/lid; other site
359391005682	ABC transporter signature motif; other site
359391005683	Walker B; other site
359391005684	D-loop; other site
359391005685	H-loop/switch region; other site
359391005686	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585
359391005687	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; cl19912
359391005688	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
359391005689	ParB-like nuclease domain; Region: ParB; smart00470
359391005690	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
359391005691	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
359391005692	P-loop; other site
359391005693	Magnesium ion binding site [ion binding]; other site
359391005694	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
359391005695	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
359391005696	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
359391005697	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
359391005698	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
359391005699	Predicted GTPase [General function prediction only]; Region: ThdF; COG0486
359391005700	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
359391005701	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
359391005702	trmE is a tRNA modification GTPase; Region: trmE; cd04164
359391005703	G1 box; other site
359391005704	G1 box; other site
359391005705	GTP/Mg2+ binding site [chemical binding]; other site
359391005706	GTP/Mg2+ binding site [chemical binding]; other site
359391005707	Switch I region; other site
359391005708	Switch I region; other site
359391005709	G2 box; other site
359391005710	G2 box; other site
359391005711	Switch II region; other site
359391005712	G3 box; other site
359391005713	G4 box; other site
359391005714	G5 box; other site
359391005715	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
359391005716	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
359391005717	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
359391005718	catalytic residues [active]
359391005719	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
359391005720	transcription termination factor Rho; Provisional; Region: rho; PRK09376
359391005721	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
359391005722	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
359391005723	RNA binding site [nucleotide binding]; other site
359391005724	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
359391005725	multimer interface [polypeptide binding]; other site
359391005726	Walker A motif; other site
359391005727	ATP binding site [chemical binding]; other site
359391005728	Walker B motif; other site
359391005729	Predicted membrane protein [Function unknown]; Region: COG1981
359391005730	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
359391005731	substrate binding site [chemical binding]; other site
359391005732	active site
359391005733	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806
359391005734	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
359391005735	active site
359391005736	dimer interface [polypeptide binding]; other site
359391005737	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
359391005738	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
359391005739	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
359391005740	shikimate binding site; other site
359391005741	NAD(P) binding site [chemical binding]; other site
359391005742	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
359391005743	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
359391005744	CoA-binding site [chemical binding]; other site
359391005745	ATP-binding [chemical binding]; other site
359391005746	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
359391005747	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
359391005748	active site
359391005749	catalytic site [active]
359391005750	substrate binding site [chemical binding]; other site
359391005751	Frequency clock protein; Region: FRQ; pfam09421
359391005752	Preprotein translocase subunit SecB [Intracellular trafficking and secretion]; Region: SecB; COG1952
359391005753	SecA binding site; other site
359391005754	Preprotein binding site; other site
359391005755	Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030
359391005756	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395
359391005757	Tim44-like domain; Region: Tim44; pfam04280
359391005758	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
359391005759	MltA specific insert domain; Region: MltA; smart00925
359391005760	3D domain; Region: 3D; pfam06725
359391005761	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
359391005762	Smr domain; Region: Smr; pfam01713
359391005763	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
359391005764	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
359391005765	non-specific DNA binding site [nucleotide binding]; other site
359391005766	salt bridge; other site
359391005767	sequence-specific DNA binding site [nucleotide binding]; other site
359391005768	Protein of unknown function (DUF1402); Region: DUF1402; pfam07182
359391005769	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
359391005770	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
359391005771	Walker A motif; other site
359391005772	ATP binding site [chemical binding]; other site
359391005773	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
359391005774	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
359391005775	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
359391005776	active site
359391005777	HslU subunit interaction site [polypeptide binding]; other site
359391005778	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
359391005779	putative active site pocket [active]
359391005780	4-fold oligomerization interface [polypeptide binding]; other site
359391005781	metal binding residues [ion binding]; metal-binding site
359391005782	3-fold/trimer interface [polypeptide binding]; other site
359391005783	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
359391005784	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142
359391005785	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
359391005786	putative active site [active]
359391005787	oxyanion strand; other site
359391005788	catalytic triad [active]
359391005789	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
359391005790	catalytic residues [active]
359391005791	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
359391005792	substrate binding site [chemical binding]; other site
359391005793	glutamase interaction surface [polypeptide binding]; other site
359391005794	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
359391005795	metal binding site [ion binding]; metal-binding site
359391005796	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
359391005797	ATP-binding site [chemical binding]; other site
359391005798	CoA-binding site [chemical binding]; other site
359391005799	Mg2+-binding site [ion binding]; other site
359391005800	hypothetical protein; Provisional; Region: PRK09256
359391005801	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
359391005802	phosphoenolpyruvate carboxykinase (ATP)
359391005803	Phosphoenolpyruvate carboxykinase (ATP):ATP/GTP-binding site motif A (P-loop)
359391005804	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
359391005805	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
359391005806	active site
359391005807	phosphorylation site [posttranslational modification]
359391005808	intermolecular recognition site; other site
359391005809	dimerization interface [polypeptide binding]; other site
359391005810	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
359391005811	DNA binding site [nucleotide binding]
359391005812	Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755
359391005813	Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756
359391005814	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
359391005815	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
359391005816	dimerization interface [polypeptide binding]; other site
359391005817	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
359391005818	dimer interface [polypeptide binding]; other site
359391005819	phosphorylation site [posttranslational modification]
359391005820	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
359391005821	ATP binding site [chemical binding]; other site
359391005822	Mg2+ binding site [ion binding]; other site
359391005823	G-X-G motif; other site
359391005824	Serine kinase of the HPr protein, regulates carbohydrate metabolism [Signal transduction mechanisms]; Region: HprK; COG1493
359391005825	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
359391005826	Hpr binding site; other site
359391005827	active site
359391005828	homohexamer subunit interaction site [polypeptide binding]; other site
359391005829	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
359391005830	active pocket/dimerization site; other site
359391005831	active site
359391005832	phosphorylation site [posttranslational modification]
359391005833	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
359391005834	dimerization domain swap beta strand [polypeptide binding]; other site
359391005835	regulatory protein interface [polypeptide binding]; other site
359391005836	active site
359391005837	regulatory phosphorylation site [posttranslational modification]; other site
359391005838	conserved hypothetical protein
359391005839	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
359391005840	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
359391005841	homotetramer interface [polypeptide binding]; other site
359391005842	ligand binding site [chemical binding]; other site
359391005843	catalytic site [active]
359391005844	NAD binding site [chemical binding]; other site
359391005845	PAS fold; Region: PAS_7; pfam12860
359391005846	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
359391005847	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
359391005848	dimer interface [polypeptide binding]; other site
359391005849	phosphorylation site [posttranslational modification]
359391005850	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
359391005851	ATP binding site [chemical binding]; other site
359391005852	Mg2+ binding site [ion binding]; other site
359391005853	G-X-G motif; other site
359391005854	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
359391005855	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
359391005856	Phosphotransferase enzyme family; Region: APH; pfam01636
359391005857	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
359391005858	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
359391005859	Substrate binding site; other site
359391005860	metal-binding site
359391005861	Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893
359391005862	double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786
359391005863	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
359391005864	double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784
359391005865	Part of AAA domain; Region: AAA_19; pfam13245
359391005866	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402
359391005867	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
359391005868	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
359391005869	catalytic residues [active]
359391005870	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
359391005871	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
359391005872	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
359391005873	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
359391005874	substrate binding site [chemical binding]; other site
359391005875	active site
359391005876	catalytic residues [active]
359391005877	heterodimer interface [polypeptide binding]; other site
359391005878	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
359391005879	pyridoxal 5'-phosphate binding site [chemical binding]; other site
359391005880	catalytic residue [active]
359391005881	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
359391005882	active site
359391005883	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
359391005884	putative active site [active]
359391005885	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
359391005886	conserved hypothetical protein
359391005887	conserved hypothetical protein
359391005888	benzoate transport protein, putative
359391005889	Benzoate membrane transport protein
359391005890	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
359391005891	Putative lysophospholipase; Region: Hydrolase_4; cl19140
359391005892	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
359391005893	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
359391005894	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
359391005895	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
359391005896	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
359391005897	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
359391005898	23S rRNA binding site [nucleotide binding]; other site
359391005899	L21 binding site [polypeptide binding]; other site
359391005900	L13 binding site [polypeptide binding]; other site
359391005901	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
359391005902	active site
359391005903	ATP binding site [chemical binding]; other site
359391005904	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
359391005905	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
359391005906	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
359391005907	dimer interface [polypeptide binding]; other site
359391005908	motif 1; other site
359391005909	active site
359391005910	motif 2; other site
359391005911	motif 3; other site
359391005912	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
359391005913	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
359391005914	putative tRNA-binding site [nucleotide binding]; other site
359391005915	B3/4 domain; Region: B3_4; pfam03483
359391005916	tRNA synthetase B5 domain; Region: B5; smart00874
359391005917	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
359391005918	dimer interface [polypeptide binding]; other site
359391005919	motif 1; other site
359391005920	motif 3; other site
359391005921	motif 2; other site
359391005922	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
359391005923	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
359391005924	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
359391005925	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
359391005926	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
359391005927	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
359391005928	nucleotide binding site [chemical binding]; other site
359391005929	NEF interaction site [polypeptide binding]; other site
359391005930	SBD interface [polypeptide binding]; other site
359391005931	chaperone protein DnaJ; Provisional; Region: PRK10767
359391005932	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
359391005933	HSP70 interaction site [polypeptide binding]; other site
359391005934	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
359391005935	substrate binding site [polypeptide binding]; other site
359391005936	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
359391005937	Zn binding sites [ion binding]; other site
359391005938	dimer interface [polypeptide binding]; other site
359391005939	Phospholipid N-methyltransferase [Lipid metabolism]; Region: COG3963
359391005940	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
359391005941	active site
359391005942	dimer interface [polypeptide binding]; other site
359391005943	Uncharacterized conserved protein [Function unknown]; Region: COG5470
359391005944	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
359391005945	glutathione synthetase; Provisional; Region: PRK05246
359391005946	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
359391005947	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
359391005948	Magnesium chelatase, ChlI subunit:Shikimate kinase:ATP/GTP-binding site motif A (P-loop):AAA ATPase:Mg chelatase-related protein
359391005949	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: Peptidase_C93; pfam06035
359391005950	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
359391005951	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
359391005952	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
359391005953	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
359391005954	Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501
359391005955	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
359391005956	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391005957	dimer interface [polypeptide binding]; other site
359391005958	conserved gate region; other site
359391005959	putative PBP binding loops; other site
359391005960	ABC-ATPase subunit interface; other site
359391005961	Domain of unknown function (DUF3333); Region: DUF3333; pfam11812
359391005962	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
359391005963	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391005964	dimer interface [polypeptide binding]; other site
359391005965	conserved gate region; other site
359391005966	putative PBP binding loops; other site
359391005967	ABC-ATPase subunit interface; other site
359391005968	phosphate transporter ATP-binding protein; Provisional; Region: PRK14235
359391005969	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
359391005970	Walker A/P-loop; other site
359391005971	ATP binding site [chemical binding]; other site
359391005972	Q-loop/lid; other site
359391005973	ABC transporter signature motif; other site
359391005974	Walker B; other site
359391005975	D-loop; other site
359391005976	H-loop/switch region; other site
359391005977	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
359391005978	PhoU domain; Region: PhoU; pfam01895
359391005979	PhoU domain; Region: PhoU; pfam01895
359391005980	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
359391005981	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
359391005982	active site
359391005983	phosphorylation site [posttranslational modification]
359391005984	intermolecular recognition site; other site
359391005985	dimerization interface [polypeptide binding]; other site
359391005986	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
359391005987	DNA binding site [nucleotide binding]
359391005988	Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773
359391005989	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
359391005990	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
359391005991	Ferritin-like domain; Region: Ferritin; pfam00210
359391005992	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
359391005993	dimerization interface [polypeptide binding]; other site
359391005994	DPS ferroxidase diiron center [ion binding]; other site
359391005995	ion pore; other site
359391005996	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
359391005997	Glycoprotease family; Region: Peptidase_M22; pfam00814
359391005998	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
359391005999	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
359391006000	Coenzyme A binding pocket [chemical binding]; other site
359391006001	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
359391006002	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
359391006003	putative acyl-acceptor binding pocket; other site
359391006004	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
359391006005	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
359391006006	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
359391006007	FeS/SAM binding site; other site
359391006008	TRAM domain; Region: TRAM; cl01282
359391006009	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
359391006010	PhoH-like protein; Region: PhoH; pfam02562
359391006011	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319
359391006012	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
359391006013	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
359391006014	Transporter associated domain; Region: CorC_HlyC; smart01091
359391006015	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
359391006016	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176
359391006017	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
359391006018	putative active site [active]
359391006019	catalytic triad [active]
359391006020	putative dimer interface [polypeptide binding]; other site
359391006021	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
359391006022	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
359391006023	non-specific DNA binding site [nucleotide binding]; other site
359391006024	salt bridge; other site
359391006025	sequence-specific DNA binding site [nucleotide binding]; other site
359391006026	S-adenosylmethionine synthetase; Validated; Region: PRK05250
359391006027	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
359391006028	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
359391006029	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
359391006030	Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only]; Region: COG0220
359391006031	Sm and related proteins; Region: Sm_like; cl00259
359391006032	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
359391006033	putative oligomer interface [polypeptide binding]; other site
359391006034	putative RNA binding site [nucleotide binding]; other site
359391006035	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
359391006036	NusA N-terminal domain; Region: NusA_N; pfam08529
359391006037	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
359391006038	RNA binding site [nucleotide binding]; other site
359391006039	homodimer interface [polypeptide binding]; other site
359391006040	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
359391006041	G-X-X-G motif; other site
359391006042	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
359391006043	G-X-X-G motif; other site
359391006044	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
359391006045	hypothetical protein; Provisional; Region: PRK09190
359391006046	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
359391006047	putative RNA binding cleft [nucleotide binding]; other site
359391006048	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
359391006049	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
359391006050	TolA protein; Region: tolA_full; TIGR02794
359391006051	Translation initiation factor eIF3 subunit; Region: eIF3_subunit; pfam08597
359391006052	translation initiation factor IF-2; Validated; Region: infB; PRK05306
359391006053	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
359391006054	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
359391006055	G1 box; other site
359391006056	putative GEF interaction site [polypeptide binding]; other site
359391006057	GTP/Mg2+ binding site [chemical binding]; other site
359391006058	Switch I region; other site
359391006059	G2 box; other site
359391006060	G3 box; other site
359391006061	Switch II region; other site
359391006062	G4 box; other site
359391006063	G5 box; other site
359391006064	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
359391006065	Translation-initiation factor 2; Region: IF-2; pfam11987
359391006066	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
359391006067	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
359391006068	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389
359391006069	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
359391006070	RNA binding site [nucleotide binding]; other site
359391006071	active site
359391006072	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
359391006073	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
359391006074	16S/18S rRNA binding site [nucleotide binding]; other site
359391006075	S13e-L30e interaction site [polypeptide binding]; other site
359391006076	25S rRNA binding site [nucleotide binding]; other site
359391006077	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
359391006078	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
359391006079	RNase E interface [polypeptide binding]; other site
359391006080	trimer interface [polypeptide binding]; other site
359391006081	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
359391006082	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
359391006083	RNase E interface [polypeptide binding]; other site
359391006084	trimer interface [polypeptide binding]; other site
359391006085	active site
359391006086	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
359391006087	putative nucleic acid binding region [nucleotide binding]; other site
359391006088	G-X-X-G motif; other site
359391006089	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
359391006090	RNA binding site [nucleotide binding]; other site
359391006091	domain interface; other site
359391006092	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
359391006093	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
359391006094	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
359391006095	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
359391006096	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
359391006097	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
359391006098	NAD binding site [chemical binding]; other site
359391006099	homotetramer interface [polypeptide binding]; other site
359391006100	homodimer interface [polypeptide binding]; other site
359391006101	substrate binding site [chemical binding]; other site
359391006102	active site
359391006103	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
359391006104	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
359391006105	dimer interface [polypeptide binding]; other site
359391006106	active site
359391006107	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
359391006108	active site 1 [active]
359391006109	dimer interface [polypeptide binding]; other site
359391006110	active site 2 [active]
359391006111	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
359391006112	metal binding site 2 [ion binding]; metal-binding site
359391006113	putative DNA binding helix; other site
359391006114	metal binding site 1 [ion binding]; metal-binding site
359391006115	dimer interface [polypeptide binding]; other site
359391006116	structural Zn2+ binding site [ion binding]; other site
359391006117	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
359391006118	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807
359391006119	Bacterial SH3 domain; Region: SH3_4; pfam06347
359391006120	Bacterial SH3 domain; Region: SH3_4; pfam06347
359391006121	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
359391006122	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
359391006123	dimerization interface [polypeptide binding]; other site
359391006124	ligand binding site [chemical binding]; other site
359391006125	NADP binding site [chemical binding]; other site
359391006126	catalytic site [active]
359391006127	Putative lysophospholipase; Region: Hydrolase_4; cl19140
359391006128	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
359391006129	Bacterial SH3 domain; Region: SH3_3; pfam08239
359391006130	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
359391006131	NlpC/P60 family; Region: NLPC_P60; cl17555
359391006132	Transcriptional regulators [Transcription]; Region: MarR; COG1846
359391006133	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
359391006134	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
359391006135	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
359391006136	interface (dimer of trimers) [polypeptide binding]; other site
359391006137	Substrate-binding/catalytic site; other site
359391006138	Zn-binding sites [ion binding]; other site
359391006139	Flp/Fap pilin component; Region: Flp_Fap; cl01585
359391006140	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
359391006141	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
359391006142	DNA binding site [nucleotide binding]
359391006143	catalytic residue [active]
359391006144	H2TH interface [polypeptide binding]; other site
359391006145	putative catalytic residues [active]
359391006146	turnover-facilitating residue; other site
359391006147	intercalation triad [nucleotide binding]; other site
359391006148	8OG recognition residue [nucleotide binding]; other site
359391006149	putative reading head residues; other site
359391006150	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
359391006151	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
359391006152	enoyl-CoA hydratase; Provisional; Region: PRK05862
359391006153	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
359391006154	substrate binding site [chemical binding]; other site
359391006155	oxyanion hole (OAH) forming residues; other site
359391006156	trimer interface [polypeptide binding]; other site
359391006157	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
359391006158	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
359391006159	replication initiation protein RepC; Provisional; Region: PRK13824
359391006160	Replication protein C N-terminal domain; Region: RP-C; pfam03428
359391006161	Replication protein C C-terminal region; Region: RP-C_C; pfam11800
359391006162	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
359391006163	substrate binding site [chemical binding]; other site
359391006164	dimer interface [polypeptide binding]; other site
359391006165	ATP binding site [chemical binding]; other site
359391006166	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
359391006167	active site
359391006168	tetramer interface [polypeptide binding]; other site
359391006169	Cl-channel, voltage gated:Bacterial inner-membrane translocator
359391006170	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
359391006171	TM-ABC transporter signature motif; other site
359391006172	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
359391006173	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
359391006174	Walker A/P-loop; other site
359391006175	ATP binding site [chemical binding]; other site
359391006176	Q-loop/lid; other site
359391006177	ABC transporter signature motif; other site
359391006178	Walker B; other site
359391006179	D-loop; other site
359391006180	H-loop/switch region; other site
359391006181	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
359391006182	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
359391006183	ligand binding site [chemical binding]; other site
359391006184	Predicted secreted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5664
359391006185	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
359391006186	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
359391006187	2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220
359391006188	2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331
359391006189	putative NAD(P) binding site [chemical binding]; other site
359391006190	active site
359391006191	Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013
359391006192	hydrophobic substrate binding pocket; other site
359391006193	active site
359391006194	conserved cis-peptide bond; other site
359391006195	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
359391006196	enterobactin synthase subunit E; Provisional; Region: entE; PRK10946
359391006197	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
359391006198	acyl-activating enzyme (AAE) consensus motif; other site
359391006199	active site
359391006200	AMP binding site [chemical binding]; other site
359391006201	substrate binding site [chemical binding]; other site
359391006202	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
359391006203	isochorismate synthases; Region: isochor_syn; TIGR00543
359391006204	Condensation domain; Region: Condensation; cl19241
359391006205	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
359391006206	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
359391006207	Moco binding site; other site
359391006208	metal coordination site [ion binding]; other site
359391006209	Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117
359391006210	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
359391006211	pentapeptide MXKDX repeat protein; Region: penta_MxKDx; TIGR02953
359391006212	RNA polymerase sigma factor; Provisional; Region: PRK12539
359391006213	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
359391006214	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
359391006215	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4944
359391006216	Transcriptional regulators [Transcription]; Region: FadR; COG2186
359391006217	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
359391006218	DNA-binding site [nucleotide binding]; DNA binding site
359391006219	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
359391006220	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329
359391006221	putative ligand binding site [chemical binding]; other site
359391006222	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
359391006223	TM-ABC transporter signature motif; other site
359391006224	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
359391006225	TM-ABC transporter signature motif; other site
359391006226	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
359391006227	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
359391006228	Walker A/P-loop; other site
359391006229	ATP binding site [chemical binding]; other site
359391006230	Q-loop/lid; other site
359391006231	ABC transporter signature motif; other site
359391006232	Walker B; other site
359391006233	D-loop; other site
359391006234	H-loop/switch region; other site
359391006235	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
359391006236	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
359391006237	Walker A/P-loop; other site
359391006238	ATP binding site [chemical binding]; other site
359391006239	Q-loop/lid; other site
359391006240	ABC transporter signature motif; other site
359391006241	Walker B; other site
359391006242	D-loop; other site
359391006243	H-loop/switch region; other site
359391006244	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
359391006245	active site
359391006246	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
359391006247	classical (c) SDRs; Region: SDR_c; cd05233
359391006248	NAD(P) binding site [chemical binding]; other site
359391006249	active site
359391006250	Short-chain dehydrogenase/reductase SDR:Glucose/ribitol dehydrogenase
359391006251	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
359391006252	tetramer interface [polypeptide binding]; other site
359391006253	TPP-binding site [chemical binding]; other site
359391006254	heterodimer interface [polypeptide binding]; other site
359391006255	phosphorylation loop region [posttranslational modification]
359391006256	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
359391006257	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
359391006258	alpha subunit interface [polypeptide binding]; other site
359391006259	TPP binding site [chemical binding]; other site
359391006260	heterodimer interface [polypeptide binding]; other site
359391006261	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
359391006262	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
359391006263	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
359391006264	E3 interaction surface; other site
359391006265	lipoyl attachment site [posttranslational modification]; other site
359391006266	e3 binding domain; Region: E3_binding; pfam02817
359391006267	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
359391006268	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
359391006269	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
359391006270	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
359391006271	shikimate binding site; other site
359391006272	NAD(P) binding site [chemical binding]; other site
359391006273	conserved hypothetical protein
359391006274	magnesium-transporting ATPase; Provisional; Region: PRK15122
359391006275	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
359391006276	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
359391006277	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
359391006278	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
359391006279	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
359391006280	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
359391006281	MgtC family; Region: MgtC; pfam02308
359391006282	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
359391006283	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
359391006284	dimer interface [polypeptide binding]; other site
359391006285	phosphorylation site [posttranslational modification]
359391006286	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
359391006287	ATP binding site [chemical binding]; other site
359391006288	Mg2+ binding site [ion binding]; other site
359391006289	G-X-G motif; other site
359391006290	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
359391006291	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
359391006292	active site
359391006293	phosphorylation site [posttranslational modification]
359391006294	intermolecular recognition site; other site
359391006295	dimerization interface [polypeptide binding]; other site
359391006296	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
359391006297	dimerization interface [polypeptide binding]; other site
359391006298	DNA binding residues [nucleotide binding]
359391006299	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
359391006300	active site
359391006301	phosphorylation site [posttranslational modification]
359391006302	intermolecular recognition site; other site
359391006303	dimerization interface [polypeptide binding]; other site
359391006304	N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: HutG; COG3741
359391006305	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
359391006306	active site
359391006307	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
359391006308	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
359391006309	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
359391006310	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
359391006311	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
359391006312	putative dimer interface [polypeptide binding]; other site
359391006313	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
359391006314	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
359391006315	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
359391006316	catalytic residue [active]
359391006317	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
359391006318	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
359391006319	active site
359391006320	dimer interface [polypeptide binding]; other site
359391006321	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
359391006322	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
359391006323	active site
359391006324	FMN binding site [chemical binding]; other site
359391006325	substrate binding site [chemical binding]; other site
359391006326	3Fe-4S cluster binding site [ion binding]; other site
359391006327	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
359391006328	domain interface; other site
359391006329	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
359391006330	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691
359391006331	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
359391006332	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
359391006333	SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829
359391006334	active site
359391006335	catalytic triad [active]
359391006336	oxyanion hole [active]
359391006337	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
359391006338	Cag pathogenicity island protein Cag12; Region: Cag12; pfam13117
359391006339	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
359391006340	ligand binding site [chemical binding]; other site
359391006341	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
359391006342	ATP binding site [chemical binding]; other site
359391006343	Walker A motif; other site
359391006344	hexamer interface [polypeptide binding]; other site
359391006345	Walker B motif; other site
359391006346	Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948
359391006347	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
359391006348	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423
359391006349	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
359391006350	VirB7 interaction site; other site
359391006351	Type IV secretory pathway, component VirB8 [Intracellular trafficking and secretion]; Region: VirB8; COG3736
359391006352	META domain; Region: META; cl01245
359391006353	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
359391006354	Type IV secretory pathway, VirB6 components [Intracellular trafficking and secretion]; Region: VirB6; COG3704
359391006355	P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791
359391006356	Type IV secretory pathway, VirB4 components [Intracellular trafficking and secretion]; Region: VirB4; COG3451
359391006357	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
359391006358	Type IV secretory pathway, VirB3 components [Intracellular trafficking and secretion]; Region: VirB3; COG3702
359391006359	TrbC/VIRB2 family; Region: TrbC; pfam04956
359391006360	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
359391006361	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
359391006362	N-acetyl-D-glucosamine binding site [chemical binding]; other site
359391006363	catalytic residue [active]
359391006364	lytic murein transglycosylase; Region: MltB_2; TIGR02283
359391006365	Transglycosylase SLT domain; Region: SLT_2; pfam13406
359391006366	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
359391006367	N-acetyl-D-glucosamine binding site [chemical binding]; other site
359391006368	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
359391006369	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
359391006370	active site
359391006371	tetramer interface; other site
359391006372	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5338
359391006373	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
359391006374	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
359391006375	putative active site [active]
359391006376	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
359391006377	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
359391006378	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
359391006379	Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_paraslipin; cd08829
359391006380	core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107
359391006381	ferrochelatase; Reviewed; Region: hemH; PRK00035
359391006382	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
359391006383	C-terminal domain interface [polypeptide binding]; other site
359391006384	active site
359391006385	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
359391006386	active site
359391006387	N-terminal domain interface [polypeptide binding]; other site
359391006388	Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310
359391006389	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
359391006390	hypothetical protein; Provisional; Region: PRK07546
359391006391	substrate-cofactor binding pocket; other site
359391006392	pyridoxal 5'-phosphate binding site [chemical binding]; other site
359391006393	homodimer interface [polypeptide binding]; other site
359391006394	catalytic residue [active]
359391006395	aminodeoxychorismate synthase; Provisional; Region: PRK07508
359391006396	chorismate binding enzyme; Region: Chorismate_bind; cl10555
359391006397	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
359391006398	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610
359391006399	active site
359391006400	Zn binding site [ion binding]; other site
359391006401	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
359391006402	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
359391006403	active site
359391006404	phosphorylation site [posttranslational modification]
359391006405	intermolecular recognition site; other site
359391006406	dimerization interface [polypeptide binding]; other site
359391006407	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
359391006408	Walker A motif; other site
359391006409	ATP binding site [chemical binding]; other site
359391006410	Walker B motif; other site
359391006411	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
359391006412	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
359391006413	Bacterial protein of unknown function (DUF882); Region: Peptidase_M15_2; pfam05951
359391006414	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
359391006415	Entner-Doudoroff aldolase; Region: eda; TIGR01182
359391006416	active site
359391006417	intersubunit interface [polypeptide binding]; other site
359391006418	catalytic residue [active]
359391006419	Protein of unknown function (DUF3380); Region: DUF3380; pfam11860
359391006420	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
359391006421	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
359391006422	active site residue [active]
359391006423	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
359391006424	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
359391006425	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391006426	dimer interface [polypeptide binding]; other site
359391006427	conserved gate region; other site
359391006428	putative PBP binding loops; other site
359391006429	ABC-ATPase subunit interface; other site
359391006430	ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148
359391006431	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
359391006432	Walker A/P-loop; other site
359391006433	ATP binding site [chemical binding]; other site
359391006434	Q-loop/lid; other site
359391006435	ABC transporter signature motif; other site
359391006436	Walker B; other site
359391006437	D-loop; other site
359391006438	H-loop/switch region; other site
359391006439	TOBE domain; Region: TOBE; cl01440
359391006440	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
359391006441	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
359391006442	conserved hypothetical protein
359391006443	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215
359391006444	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683
359391006445	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
359391006446	LysR family transcriptional regulator; Provisional; Region: PRK14997
359391006447	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
359391006448	putative effector binding pocket; other site
359391006449	dimerization interface [polypeptide binding]; other site
359391006450	amidase; Provisional; Region: PRK08310
359391006451	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
359391006452	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
359391006453	dimer interface [polypeptide binding]; other site
359391006454	active site
359391006455	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
359391006456	catalytic residues [active]
359391006457	substrate binding site [chemical binding]; other site
359391006458	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
359391006459	Chain length determinant protein; Region: Wzz; pfam02706
359391006460	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
359391006461	Glycosyl transferase WecB/TagA/CpsF family
359391006462	glycosyl transferase, WecB/TagA/CpsF family
359391006463	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
359391006464	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
359391006465	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
359391006466	active site
359391006467	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
359391006468	O-Antigen ligase; Region: Wzy_C; pfam04932
359391006469	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
359391006470	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
359391006471	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
359391006472	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
359391006473	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
359391006474	6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG0362
359391006475	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
359391006476	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
359391006477	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
359391006478	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
359391006479	Walker A/P-loop; other site
359391006480	ATP binding site [chemical binding]; other site
359391006481	Q-loop/lid; other site
359391006482	ABC transporter signature motif; other site
359391006483	Walker B; other site
359391006484	D-loop; other site
359391006485	H-loop/switch region; other site
359391006486	TOBE domain; Region: TOBE_2; pfam08402
359391006487	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
359391006488	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391006489	dimer interface [polypeptide binding]; other site
359391006490	conserved gate region; other site
359391006491	putative PBP binding loops; other site
359391006492	ABC-ATPase subunit interface; other site
359391006493	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
359391006494	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391006495	dimer interface [polypeptide binding]; other site
359391006496	conserved gate region; other site
359391006497	putative PBP binding loops; other site
359391006498	ABC-ATPase subunit interface; other site
359391006499	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
359391006500	Major facilitator superfamily (MFS)
359391006501	Major facilitator superfamily (MFS)
359391006502	Secretion protein HlyD
359391006503	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
359391006504	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
359391006505	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
359391006506	Autoinducer binding domain; Region: Autoind_bind; pfam03472
359391006507	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
359391006508	DNA binding residues [nucleotide binding]
359391006509	dimerization interface [polypeptide binding]; other site
359391006510	Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377
359391006511	Flagellar motor switch protein FliG
359391006512	flagellar motor switch protein FliN; Region: fliN; TIGR02480
359391006513	Surface presentation of antigens (SPOA) protein
359391006514	ATP/GTP-binding site motif A (P-loop):Flagellar motor switch protein FliM
359391006515	flagellar motor protein MotA; Validated; Region: PRK09110
359391006516	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
359391006517	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
359391006518	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642
359391006519	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
359391006520	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
359391006521	flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002
359391006522	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
359391006523	Walker A motif; other site
359391006524	ATP binding site [chemical binding]; other site
359391006525	Walker B motif; other site
359391006526	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
359391006527	PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389
359391006528	active site
359391006529	GtrA-like protein; Region: GtrA; pfam04138
359391006530	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
359391006531	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
359391006532	Ligand binding site; other site
359391006533	Putative Catalytic site; other site
359391006534	DXD motif; other site
359391006535	Peptidase family M48; Region: Peptidase_M48; cl12018
359391006536	uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807
359391006537	putative active site [active]
359391006538	YdjC motif; other site
359391006539	Mg binding site [ion binding]; other site
359391006540	putative homodimer interface [polypeptide binding]; other site
359391006541	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
359391006542	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158
359391006543	AraC-binding-like domain; Region: AraC_binding_2; pfam14525
359391006544	Helix-turn-helix domain; Region: HTH_18; pfam12833
359391006545	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
359391006546	Transposase; Region: HTH_Tnp_1; cl17663
359391006547	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
359391006548	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
359391006549	putative substrate translocation pore; other site
359391006550	putative aldolase; Validated; Region: PRK08130
359391006551	intersubunit interface [polypeptide binding]; other site
359391006552	active site
359391006553	Zn2+ binding site [ion binding]; other site
359391006554	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
359391006555	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
359391006556	NAD(P) binding site [chemical binding]; other site
359391006557	active site
359391006558	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
359391006559	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
359391006560	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
359391006561	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
359391006562	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
359391006563	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
359391006564	D-beta-hydroxybutyrate dehydrogenase
359391006565	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003
359391006566	flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173
359391006567	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782
359391006568	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
359391006569	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
359391006570	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790
359391006571	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691
359391006572	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
359391006573	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
359391006574	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
359391006575	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
359391006576	Flagellar P-ring protein
359391006577	Flagellar P-ring protein
359391006578	Uncharacterized conserved protein [Function unknown]; Region: COG3334
359391006579	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
359391006580	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
359391006581	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
359391006582	FliP family; Region: FliP; cl00593
359391006583	Domain of unknown function (DUF4381); Region: DUF4381; pfam14316
359391006584	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4893
359391006585	Transcriptional regulator [Transcription]; Region: LysR; COG0583
359391006586	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
359391006587	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
359391006588	putative dimerization interface [polypeptide binding]; other site
359391006589	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
359391006590	Uncharacterized conserved protein [Function unknown]; Region: COG3777
359391006591	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
359391006592	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
359391006593	active site 2 [active]
359391006594	active site 1 [active]
359391006595	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
359391006596	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
359391006597	conserved hypothetical protein
359391006599	Autotransporter beta-domain
359391006600	Cytochrome c2 [Energy production and conversion]; Region: COG3474
359391006601	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841
359391006602	transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464
359391006603	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
359391006604	DNA-binding site [nucleotide binding]; DNA binding site
359391006605	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
359391006606	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
359391006607	transcriptional activator TtdR; Provisional; Region: PRK09801
359391006608	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
359391006609	putative effector binding pocket; other site
359391006610	dimerization interface [polypeptide binding]; other site
359391006611	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
359391006612	FAD binding domain; Region: FAD_binding_4; pfam01565
359391006613	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
359391006614	FAD binding domain; Region: FAD_binding_4; pfam01565
359391006615	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
359391006616	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
359391006617	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
359391006618	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
359391006619	Cysteine-rich domain; Region: CCG; pfam02754
359391006620	Cysteine-rich domain; Region: CCG; pfam02754
359391006621	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
359391006622	active site
359391006623	catalytic tetrad [active]
359391006624	ErfK/YbiS/YcfS/YnhG
359391006625	3-methyladenine DNA glycosylase [DNA replication, recombination, and repair]; Region: Tag; COG2818
359391006626	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
359391006627	Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124
359391006628	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
359391006629	dimer interface [polypeptide binding]; other site
359391006630	motif 1; other site
359391006631	active site
359391006632	motif 2; other site
359391006633	motif 3; other site
359391006634	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
359391006635	anticodon binding site; other site
359391006636	ATP phosphoribosyltransferase involved in histidine biosynthesis [Amino acid transport and metabolism]; Region: HisZ; COG3705
359391006637	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295
359391006638	motif 1; other site
359391006639	dimer interface [polypeptide binding]; other site
359391006640	active site
359391006641	motif 2; other site
359391006642	motif 3; other site
359391006643	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
359391006644	ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583
359391006645	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
359391006646	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
359391006647	putative substrate translocation pore; other site
359391006648	Predicted membrane protein [Function unknown]; Region: COG2259
359391006649	fumarate hydratase; Reviewed; Region: fumC; PRK00485
359391006650	Class II fumarases; Region: Fumarase_classII; cd01362
359391006651	active site
359391006652	tetramer interface [polypeptide binding]; other site
359391006653	chaperonin GroEL; Reviewed; Region: groEL; PRK12850
359391006654	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
359391006655	ring oligomerisation interface [polypeptide binding]; other site
359391006656	ATP/Mg binding site [chemical binding]; other site
359391006657	stacking interactions; other site
359391006658	hinge regions; other site
359391006659	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
359391006660	oligomerisation interface [polypeptide binding]; other site
359391006661	mobile loop; other site
359391006662	roof hairpin; other site
359391006663	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
359391006664	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
359391006665	active site
359391006666	motif I; other site
359391006667	motif II; other site
359391006668	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
359391006669	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
359391006670	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
359391006671	active site
359391006672	Riboflavin kinase; Region: Flavokinase; smart00904
359391006673	isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804
359391006674	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
359391006675	active site
359391006676	HIGH motif; other site
359391006677	nucleotide binding site [chemical binding]; other site
359391006678	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
359391006679	active site
359391006680	KMSKS motif; other site
359391006681	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
359391006682	tRNA binding surface [nucleotide binding]; other site
359391006683	anticodon binding site; other site
359391006684	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
359391006685	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
359391006686	nucleoside/Zn binding site; other site
359391006687	dimer interface [polypeptide binding]; other site
359391006688	catalytic motif [active]
359391006689	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
359391006690	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
359391006691	RNA binding surface [nucleotide binding]; other site
359391006692	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
359391006693	active site
359391006694	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
359391006695	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
359391006696	S-adenosylmethionine binding site [chemical binding]; other site
359391006697	Insulinase-like peptidase, family M16:Peptidase M16 inactive
359391006698	zinc protease
359391006699	Peptidase M16 inactive
359391006700	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
359391006701	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
359391006702	active site
359391006703	nucleophile elbow; other site
359391006704	glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659
359391006705	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
359391006706	TrkA-N domain; Region: TrkA_N; pfam02254
359391006707	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
359391006708	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
359391006709	active site
359391006710	Domain of unknown function (DUF4170); Region: DUF4170; pfam13773
359391006711	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
359391006712	putative acyl-acceptor binding pocket; other site
359391006713	3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519
359391006714	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
359391006715	Glycosyl transferases group 1; Region: Glycos_transf_1; cl19138
359391006716	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
359391006717	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3908
359391006718	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
359391006719	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
359391006720	ATP binding site [chemical binding]; other site
359391006721	Mg2+ binding site [ion binding]; other site
359391006722	G-X-G motif; other site
359391006723	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
359391006724	ATP binding site [chemical binding]; other site
359391006725	MutL C terminal dimerization domain; Region: MutL_C; pfam08676
359391006726	benzoate transport; Region: 2A0115; TIGR00895
359391006727	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
359391006728	putative substrate translocation pore; other site
359391006729	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
359391006730	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
359391006731	active site
359391006732	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
359391006733	Transcriptional regulator [Transcription]; Region: IclR; COG1414
359391006734	Bacterial transcriptional regulator; Region: IclR; pfam01614
359391006735	NAD binding site:FAD-dependent pyridine nucleotide-disulphide oxidoreductase:Enoyl-CoA hydratase/isomerase:3-hydroxyacyl-CoA...
359391006736	L-carnitine dehydratase/bile acid-inducible protein F
359391006737	CAIB/BAIF family protein
359391006738	Old yellow enzyme (OYE)-related FMN binding domain, group 2.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733
359391006739	putative active site [active]
359391006740	putative FMN binding site [chemical binding]; other site
359391006741	putative substrate binding site [chemical binding]; other site
359391006742	putative catalytic residue [active]
359391006743	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg7; cd04786
359391006744	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
359391006745	DNA binding residues [nucleotide binding]
359391006746	putative dimer interface [polypeptide binding]; other site
359391006747	sensor protein QseC; Provisional; Region: PRK10337
359391006748	HAMP domain; Region: HAMP; pfam00672
359391006749	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
359391006750	dimer interface [polypeptide binding]; other site
359391006751	phosphorylation site [posttranslational modification]
359391006752	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
359391006753	ATP binding site [chemical binding]; other site
359391006754	Mg2+ binding site [ion binding]; other site
359391006755	G-X-G motif; other site
359391006756	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
359391006757	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
359391006758	active site
359391006759	phosphorylation site [posttranslational modification]
359391006760	intermolecular recognition site; other site
359391006761	dimerization interface [polypeptide binding]; other site
359391006762	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
359391006763	DNA binding site [nucleotide binding]
359391006764	Peptidase propeptide and YPEB domain; Region: PepSY_2; cl17877
359391006765	Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029
359391006766	oxidoreductase, FAD-binding, putative
359391006767	Phthalate dioxygenase reductase:Flavodoxin-like domain:Phenol hydroxylase reductase:Flavodoxin:Oxidoreductase FAD/NAD(P)-bind...
359391006768	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
359391006769	GGDEF
359391006770	conserved hypothetical protein
359391006771	glutathionine S-transferase; Provisional; Region: PRK10542
359391006772	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
359391006773	C-terminal domain interface [polypeptide binding]; other site
359391006774	GSH binding site (G-site) [chemical binding]; other site
359391006775	dimer interface [polypeptide binding]; other site
359391006776	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
359391006777	dimer interface [polypeptide binding]; other site
359391006778	N-terminal domain interface [polypeptide binding]; other site
359391006779	substrate binding pocket (H-site) [chemical binding]; other site
359391006780	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
359391006781	dimer interface [polypeptide binding]; other site
359391006782	metal binding site [ion binding]; metal-binding site
359391006783	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
359391006784	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
359391006785	N-terminal plug; other site
359391006786	ligand-binding site [chemical binding]; other site
359391006787	Glycosyl hydrolase like GH101; Region: DUF187; pfam02638
359391006788	Transcriptional regulator [Transcription]; Region: IclR; COG1414
359391006789	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
359391006790	Bacterial transcriptional regulator; Region: IclR; pfam01614
359391006791	ribose ABC transporter, periplasmic D-ribose-binding protein
359391006792	ribose ABC transporter, periplasmic D-ribose-binding protein
359391006793	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
359391006794	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
359391006795	Walker A/P-loop; other site
359391006796	ATP binding site [chemical binding]; other site
359391006797	Q-loop/lid; other site
359391006798	ABC transporter signature motif; other site
359391006799	Walker B; other site
359391006800	D-loop; other site
359391006801	H-loop/switch region; other site
359391006802	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
359391006803	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
359391006804	TM-ABC transporter signature motif; other site
359391006805	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
359391006806	TM-ABC transporter signature motif; other site
359391006807	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
359391006808	homotrimer interaction site [polypeptide binding]; other site
359391006809	putative active site [active]
359391006810	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
359391006811	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
359391006812	YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107
359391006813	Moco binding site; other site
359391006814	metal coordination site [ion binding]; other site
359391006815	Predicted esterase [General function prediction only]; Region: COG0400
359391006816	putative hydrolase; Provisional; Region: PRK11460
359391006817	FOG: WD40 repeat [General function prediction only]; Region: COG2319
359391006818	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
359391006819	structural tetrad; other site
359391006820	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
359391006821	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
359391006822	P-loop, Walker A motif; other site
359391006823	Base recognition motif; other site
359391006824	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
359391006825	Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402
359391006826	Transcriptional regulators [Transcription]; Region: MarR; COG1846
359391006827	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
359391006828	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
359391006829	Transcriptional regulators [Transcription]; Region: PurR; COG1609
359391006830	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
359391006831	DNA binding site [nucleotide binding]
359391006832	domain linker motif; other site
359391006833	Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289
359391006834	putative dimerization interface [polypeptide binding]; other site
359391006835	putative ligand binding site [chemical binding]; other site
359391006836	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
359391006837	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
359391006838	putative ligand binding site [chemical binding]; other site
359391006839	NAD binding site [chemical binding]; other site
359391006840	catalytic site [active]
359391006841	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
359391006842	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
359391006843	catalytic triad [active]
359391006844	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
359391006845	classical (c) SDRs; Region: SDR_c; cd05233
359391006846	NAD(P) binding site [chemical binding]; other site
359391006847	active site
359391006848	GGDEF:EAL domain
359391006849	EAL domain
359391006850	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
359391006851	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
359391006852	Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835
359391006853	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
359391006854	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
359391006855	ligand binding site [chemical binding]; other site
359391006856	homodimer interface [polypeptide binding]; other site
359391006857	NAD(P) binding site [chemical binding]; other site
359391006858	trimer interface B [polypeptide binding]; other site
359391006859	trimer interface A [polypeptide binding]; other site
359391006860	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
359391006861	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
359391006862	Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091
359391006863	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
359391006864	SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616
359391006865	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
359391006866	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
359391006867	active site
359391006868	motif I; other site
359391006869	motif II; other site
359391006870	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
359391006871	putative active site [active]
359391006872	putative catalytic site [active]
359391006873	conserved hypothetical protein
359391006874	conserved hypothetical protein
359391006875	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
359391006876	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
359391006877	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
359391006878	TPR motif; other site
359391006879	binding surface
359391006880	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
359391006881	binding surface
359391006882	TPR motif; other site
359391006883	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
359391006884	binding surface
359391006885	TPR motif; other site
359391006886	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
359391006887	ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Region: ectoine_ehuC; TIGR03004
359391006888	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391006889	dimer interface [polypeptide binding]; other site
359391006890	conserved gate region; other site
359391006891	putative PBP binding loops; other site
359391006892	ABC-ATPase subunit interface; other site
359391006893	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
359391006894	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
359391006895	Walker A/P-loop; other site
359391006896	ATP binding site [chemical binding]; other site
359391006897	Q-loop/lid; other site
359391006898	ABC transporter signature motif; other site
359391006899	Walker B; other site
359391006900	D-loop; other site
359391006901	H-loop/switch region; other site
359391006902	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
359391006903	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
359391006904	choline dehydrogenase; Validated; Region: PRK02106
359391006905	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
359391006906	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
359391006907	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
359391006908	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
359391006909	TM-ABC transporter signature motif; other site
359391006910	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
359391006911	TM-ABC transporter signature motif; other site
359391006912	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
359391006913	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
359391006914	Walker A/P-loop; other site
359391006915	ATP binding site [chemical binding]; other site
359391006916	Q-loop/lid; other site
359391006917	ABC transporter signature motif; other site
359391006918	Walker B; other site
359391006919	D-loop; other site
359391006920	H-loop/switch region; other site
359391006921	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
359391006922	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
359391006923	Walker A/P-loop; other site
359391006924	ATP binding site [chemical binding]; other site
359391006925	Q-loop/lid; other site
359391006926	ABC transporter signature motif; other site
359391006927	Walker B; other site
359391006928	D-loop; other site
359391006929	H-loop/switch region; other site
359391006930	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
359391006931	putative ligand binding site [chemical binding]; other site
359391006932	Transcriptional regulator [Transcription]; Region: LysR; COG0583
359391006933	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
359391006934	LysR substrate binding domain; Region: LysR_substrate; pfam03466
359391006935	dimerization interface [polypeptide binding]; other site
359391006936	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
359391006937	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
359391006938	hypothetical protein; Provisional; Region: PRK06148
359391006939	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
359391006940	active site
359391006941	substrate binding site [chemical binding]; other site
359391006942	ATP binding site [chemical binding]; other site
359391006943	Peptidase family M23; Region: Peptidase_M23; pfam01551
359391006944	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
359391006945	inhibitor-cofactor binding pocket; inhibition site
359391006946	pyridoxal 5'-phosphate binding site [chemical binding]; other site
359391006947	catalytic residue [active]
359391006948	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
359391006949	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
359391006950	substrate binding pocket [chemical binding]; other site
359391006951	membrane-bound complex binding site; other site
359391006952	hinge residues; other site
359391006953	D-aminopeptidase; Reviewed; Region: PRK13128
359391006954	Beta-lactamase; Region: Beta-lactamase; pfam00144
359391006955	D-aminopeptidase, domain B; Region: DAP_B; pfam07930
359391006956	D-aminopeptidase, domain C; Region: DAP_C; pfam07932
359391006957	thiamine pyrophosphate protein; Validated; Region: PRK08199
359391006958	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
359391006959	PYR/PP interface [polypeptide binding]; other site
359391006960	dimer interface [polypeptide binding]; other site
359391006961	TPP binding site [chemical binding]; other site
359391006962	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
359391006963	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
359391006964	TPP-binding site [chemical binding]; other site
359391006965	Transcriptional regulators [Transcription]; Region: FadR; COG2186
359391006966	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
359391006967	DNA-binding site [nucleotide binding]; DNA binding site
359391006968	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
359391006969	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
359391006970	Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802
359391006971	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
359391006972	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
359391006973	dihydroxy-acid dehydratase; Provisional; Region: PRK13017
359391006974	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
359391006975	Entner-Doudoroff aldolase; Region: eda; TIGR01182
359391006976	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
359391006977	active site
359391006978	intersubunit interface [polypeptide binding]; other site
359391006979	catalytic residue [active]
359391006980	multiple sugar-binding periplasmic receptor chvE precursor
359391006981	sugar ABC transporter, periplasmic sugar-binding protein KO: K02058 simple sugar transport system substrate-binding protein
359391006982	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
359391006983	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
359391006984	Walker A/P-loop; other site
359391006985	ATP binding site [chemical binding]; other site
359391006986	Q-loop/lid; other site
359391006987	ABC transporter signature motif; other site
359391006988	Walker B; other site
359391006989	D-loop; other site
359391006990	H-loop/switch region; other site
359391006991	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
359391006992	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
359391006993	TM-ABC transporter signature motif; other site
359391006994	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
359391006995	homodimer interface [polypeptide binding]; other site
359391006996	substrate-cofactor binding pocket; other site
359391006997	pyridoxal 5'-phosphate binding site [chemical binding]; other site
359391006998	catalytic residue [active]
359391006999	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3758
359391007000	urocanate hydratase; Provisional; Region: PRK05414
359391007001	N-formylglutamate amidohydrolase; Region: hutG_amidohyd; TIGR02017
359391007002	Aromatic amino acid lyase; Region: Lyase_aromatic; pfam00221
359391007003	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
359391007004	active sites [active]
359391007005	tetramer interface [polypeptide binding]; other site
359391007006	imidazolonepropionase; Validated; Region: PRK09356
359391007007	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
359391007008	active site
359391007009	formiminoglutamate deiminase; Region: hutF; TIGR02022
359391007010	Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313
359391007011	active site
359391007012	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
359391007013	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
359391007014	DNA-binding site [nucleotide binding]; DNA binding site
359391007015	UTRA domain; Region: UTRA; pfam07702
359391007016	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
359391007017	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
359391007018	inhibitor-cofactor binding pocket; inhibition site
359391007019	pyridoxal 5'-phosphate binding site [chemical binding]; other site
359391007020	catalytic residue [active]
359391007021	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
359391007022	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
359391007023	non-specific DNA binding site [nucleotide binding]; other site
359391007024	salt bridge; other site
359391007025	sequence-specific DNA binding site [nucleotide binding]; other site
359391007026	Cupin domain; Region: Cupin_2; pfam07883
359391007027	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
359391007028	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
359391007029	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
359391007030	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
359391007031	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
359391007032	active site
359391007033	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
359391007034	dimer interface [polypeptide binding]; other site
359391007035	substrate binding site [chemical binding]; other site
359391007036	catalytic residues [active]
359391007037	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
359391007038	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
359391007039	putative DNA binding site [nucleotide binding]; other site
359391007040	putative Zn2+ binding site [ion binding]; other site
359391007041	AsnC family; Region: AsnC_trans_reg; pfam01037
359391007042	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
359391007043	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
359391007044	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
359391007045	active site
359391007046	substrate binding site [chemical binding]; other site
359391007047	FMN binding site [chemical binding]; other site
359391007048	putative catalytic residues [active]
359391007049	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
359391007050	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
359391007051	putative molybdopterin cofactor binding site [chemical binding]; other site
359391007052	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
359391007053	putative molybdopterin cofactor binding site; other site
359391007054	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
359391007055	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
359391007056	Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169
359391007057	HlyD family secretion protein; Region: HlyD_3; pfam13437
359391007058	putative membrane fusion protein; Region: TIGR02828
359391007059	secretion protein, putative
359391007060	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
359391007061	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
359391007062	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
359391007063	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
359391007064	DNA-binding site [nucleotide binding]; DNA binding site
359391007065	UTRA domain; Region: UTRA; pfam07702
359391007066	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
359391007067	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
359391007068	dimer interface [polypeptide binding]; other site
359391007069	active site
359391007070	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
359391007071	dimer interface [polypeptide binding]; other site
359391007072	active site
359391007073	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
359391007074	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
359391007075	active site
359391007076	dimer interface [polypeptide binding]; other site
359391007077	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
359391007078	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
359391007079	putative active site [active]
359391007080	formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011
359391007081	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
359391007082	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
359391007083	putative active site [active]
359391007084	putative substrate binding site [chemical binding]; other site
359391007085	putative cosubstrate binding site; other site
359391007086	catalytic site [active]
359391007087	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
359391007088	tetrameric interface [polypeptide binding]; other site
359391007089	NAD binding site [chemical binding]; other site
359391007090	catalytic residues [active]
359391007091	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
359391007092	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
359391007093	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
359391007094	The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481
359391007095	dimerization interface [polypeptide binding]; other site
359391007096	substrate binding pocket [chemical binding]; other site
359391007097	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
359391007098	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
359391007099	Ribosomal protein S1:RNA binding S1
359391007100	Ribonuclease RNase H fold containing
359391007101	tex protein, putative
359391007102	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
359391007103	dimerization interface [polypeptide binding]; other site
359391007104	putative DNA binding site [nucleotide binding]; other site
359391007105	putative Zn2+ binding site [ion binding]; other site
359391007106	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
359391007107	FMN binding site [chemical binding]; other site
359391007108	active site
359391007109	substrate binding site [chemical binding]; other site
359391007110	catalytic residue [active]
359391007111	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
359391007112	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
359391007113	Arginase family; Region: Arginase; cd09989
359391007114	active site
359391007115	Mn binding site [ion binding]; other site
359391007116	oligomer interface [polypeptide binding]; other site
359391007117	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
359391007118	ornithine cyclodeaminase; Validated; Region: PRK07589
359391007119	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
359391007120	apolar tunnel; other site
359391007121	heme binding site [chemical binding]; other site
359391007122	dimerization interface [polypeptide binding]; other site
359391007123	This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335
359391007124	putative deacylase active site [active]
359391007125	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
359391007126	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
359391007127	catalytic residues [active]
359391007128	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
359391007129	binding surface
359391007130	TPR motif; other site
359391007131	Tetratricopeptide repeat; Region: TPR_20; pfam14561
359391007132	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
359391007133	Uncharacterized conserved protein [Function unknown]; Region: COG2835
359391007134	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
359391007135	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
359391007136	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
359391007137	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
359391007138	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
359391007139	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
359391007140	DNA binding site [nucleotide binding]
359391007141	active site
359391007142	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
359391007143	putative substrate translocation pore; other site
359391007144	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
359391007145	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118
359391007146	Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774
359391007147	Transcriptional regulators [Transcription]; Region: MarR; COG1846
359391007148	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
359391007149	putative Zn2+ binding site [ion binding]; other site
359391007150	putative DNA binding site [nucleotide binding]; other site
359391007151	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
359391007152	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
359391007153	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
359391007154	substrate binding site [chemical binding]; other site
359391007155	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
359391007156	Uncharacterized conserved small protein [Function unknown]; Region: COG5515
359391007157	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238
359391007158	dimer interface [polypeptide binding]; other site
359391007159	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
359391007160	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
359391007161	active site
359391007162	Zn binding site [ion binding]; other site
359391007163	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
359391007164	MgtE intracellular N domain; Region: MgtE_N; pfam03448
359391007165	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
359391007166	Divalent cation transporter; Region: MgtE; pfam01769
359391007167	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
359391007168	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
359391007169	G1 box; other site
359391007170	putative GEF interaction site [polypeptide binding]; other site
359391007171	GTP/Mg2+ binding site [chemical binding]; other site
359391007172	Switch I region; other site
359391007173	G2 box; other site
359391007174	G3 box; other site
359391007175	Switch II region; other site
359391007176	G4 box; other site
359391007177	G5 box; other site
359391007178	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
359391007179	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
359391007180	Uncharacterized conserved protein [Function unknown]; Region: COG1739
359391007181	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
359391007182	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
359391007183	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
359391007184	AMP binding site [chemical binding]; other site
359391007185	metal binding site [ion binding]; metal-binding site
359391007186	active site
359391007187	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
359391007188	intersubunit interface [polypeptide binding]; other site
359391007189	active site
359391007190	zinc binding site [ion binding]; other site
359391007191	Na+ binding site [ion binding]; other site
359391007192	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
359391007193	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
359391007194	substrate binding site [chemical binding]; other site
359391007195	dimer interface [polypeptide binding]; other site
359391007196	catalytic triad [active]
359391007197	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
359391007198	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
359391007199	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
359391007200	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
359391007201	PCI domain; Region: PCI; cl02111
359391007202	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
359391007203	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
359391007204	glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369
359391007205	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
359391007206	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
359391007207	L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802
359391007208	putative N- and C-terminal domain interface [polypeptide binding]; other site
359391007209	putative active site [active]
359391007210	MgATP binding site [chemical binding]; other site
359391007211	catalytic site [active]
359391007212	metal binding site [ion binding]; metal-binding site
359391007213	putative xylulose binding site [chemical binding]; other site
359391007214	Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; pfam10054
359391007215	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
359391007216	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
359391007217	Walker A/P-loop; other site
359391007218	ATP binding site [chemical binding]; other site
359391007219	Q-loop/lid; other site
359391007220	ABC transporter signature motif; other site
359391007221	Walker B; other site
359391007222	D-loop; other site
359391007223	H-loop/switch region; other site
359391007224	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
359391007225	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
359391007226	TM-ABC transporter signature motif; other site
359391007227	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
359391007228	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
359391007229	ligand binding site [chemical binding]; other site
359391007230	dimerization interface [polypeptide binding]; other site
359391007231	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
359391007232	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
359391007233	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
359391007234	4-hydroxybenzoate octaprenyltransferase
359391007235	UbiA prenyltransferase
359391007236	FAD binding domain; Region: FAD_binding_4; pfam01565
359391007237	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
359391007238	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
359391007239	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
359391007240	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
359391007241	NAD(P) binding site [chemical binding]; other site
359391007242	active site
359391007243	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
359391007244	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
359391007245	inhibitor-cofactor binding pocket; inhibition site
359391007246	pyridoxal 5'-phosphate binding site [chemical binding]; other site
359391007247	catalytic residue [active]
359391007248	conserved hypothetical protein
359391007249	conserved hypothetical protein
359391007250	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
359391007251	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
359391007252	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
359391007253	Protein of unknown function DUF91; Region: DUF91; cl00709
359391007254	Uncharacterized conserved protein [Function unknown]; Region: COG3586
359391007255	Protein of unknown function DUF45; Region: DUF45; pfam01863
359391007256	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
359391007257	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
359391007258	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
359391007259	ATP binding site [chemical binding]; other site
359391007260	putative Mg++ binding site [ion binding]; other site
359391007261	helicase superfamily c-terminal domain; Region: HELICc; smart00490
359391007262	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
359391007263	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
359391007264	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
359391007265	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
359391007266	HsdM N-terminal domain; Region: HsdM_N; pfam12161
359391007267	Methyltransferase domain; Region: Methyltransf_26; pfam13659
359391007268	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
359391007269	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
359391007270	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
359391007271	FMN binding site [chemical binding]; other site
359391007272	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
359391007273	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
359391007274	ATP binding site [chemical binding]; other site
359391007275	putative Mg++ binding site [ion binding]; other site
359391007276	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
359391007277	nucleotide binding region [chemical binding]; other site
359391007278	ATP-binding site [chemical binding]; other site
359391007279	DEAD/H associated; Region: DEAD_assoc; pfam08494
359391007280	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
359391007281	putative active site [active]
359391007282	putative metal binding site [ion binding]; other site
359391007283	conserved hypothetical protein; Region: alph_Pro_TM; TIGR02186
359391007284	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
359391007285	metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459
359391007286	oligomer interface [polypeptide binding]; other site
359391007287	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
359391007288	Sel1-like repeats; Region: SEL1; smart00671
359391007289	Sel1-like repeats; Region: SEL1; smart00671
359391007290	Sel1-like repeats; Region: SEL1; smart00671
359391007291	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
359391007292	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
359391007293	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
359391007294	DNA binding residues [nucleotide binding]
359391007295	PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993
359391007296	camphor resistance protein CrcB; Provisional; Region: PRK14225
359391007297	camphor resistance protein CrcB; Provisional; Region: PRK14233
359391007298	membrane fusion protein MtrC
359391007299	membrane fusion protein MtrC
359391007300	Acriflavin resistance protein
359391007301	ABC transporter, family 2:Acriflavin resistance protein:Sodium:dicarboxylate symporter
359391007302	D-mannonate dehydratase [Carbohydrate transport and metabolism]; Region: UxuA; COG1312
359391007303	mannonate dehydratase; Provisional; Region: PRK03906
359391007304	Transcriptional regulators [Transcription]; Region: GntR; COG1802
359391007305	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
359391007306	DNA-binding site [nucleotide binding]; DNA binding site
359391007307	FCD domain; Region: FCD; pfam07729
359391007308	uronate isomerase
359391007309	glucuronate isomerase, putative
359391007310	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
359391007311	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
359391007312	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
359391007313	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
359391007314	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
359391007315	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
359391007316	Walker A/P-loop; other site
359391007317	ATP binding site [chemical binding]; other site
359391007318	Q-loop/lid; other site
359391007319	ABC transporter signature motif; other site
359391007320	Walker B; other site
359391007321	D-loop; other site
359391007322	H-loop/switch region; other site
359391007323	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
359391007324	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391007325	dimer interface [polypeptide binding]; other site
359391007326	conserved gate region; other site
359391007327	putative PBP binding loops; other site
359391007328	ABC-ATPase subunit interface; other site
359391007329	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
359391007330	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391007331	dimer interface [polypeptide binding]; other site
359391007332	conserved gate region; other site
359391007333	putative PBP binding loops; other site
359391007334	ABC-ATPase subunit interface; other site
359391007335	galactarate dehydratase; Region: galactar-dH20; TIGR03248
359391007336	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
359391007337	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
359391007338	nickel responsive regulator; Provisional; Region: PRK02967
359391007339	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
359391007340	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
359391007341	Bacterial extracellular solute-binding protein, family 5
359391007342	Bacterial extracellular solute-binding protein, family 5
359391007343	nickel transporter permease NikB; Provisional; Region: PRK10352
359391007344	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391007345	dimer interface [polypeptide binding]; other site
359391007346	conserved gate region; other site
359391007347	putative PBP binding loops; other site
359391007348	ABC-ATPase subunit interface; other site
359391007349	nickel transporter permease NikC; Provisional; Region: nikC; PRK10417
359391007350	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391007351	dimer interface [polypeptide binding]; other site
359391007352	conserved gate region; other site
359391007353	putative PBP binding loops; other site
359391007354	ABC-ATPase subunit interface; other site
359391007355	nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418
359391007356	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
359391007357	Walker A/P-loop; other site
359391007358	ATP binding site [chemical binding]; other site
359391007359	Q-loop/lid; other site
359391007360	ABC transporter signature motif; other site
359391007361	Walker B; other site
359391007362	D-loop; other site
359391007363	H-loop/switch region; other site
359391007364	nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419
359391007365	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
359391007366	Walker A/P-loop; other site
359391007367	ATP binding site [chemical binding]; other site
359391007368	Q-loop/lid; other site
359391007369	ABC transporter signature motif; other site
359391007370	Walker B; other site
359391007371	D-loop; other site
359391007372	H-loop/switch region; other site
359391007373	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
359391007374	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
359391007375	active site
359391007376	transcriptional regulatory protein, lysR family
359391007377	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
359391007378	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
359391007379	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
359391007380	active site
359391007381	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
359391007382	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
359391007383	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
359391007384	dimer interface [polypeptide binding]; other site
359391007385	active site
359391007386	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
359391007387	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
359391007388	substrate binding site [chemical binding]; other site
359391007389	oxyanion hole (OAH) forming residues; other site
359391007390	trimer interface [polypeptide binding]; other site
359391007391	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
359391007392	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
359391007393	Predicted transcriptional regulator [Transcription]; Region: COG2932
359391007394	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
359391007395	Catalytic site [active]
359391007396	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
359391007397	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
359391007398	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
359391007399	active site
359391007400	nucleotide binding site [chemical binding]; other site
359391007401	HIGH motif; other site
359391007402	KMSKS motif; other site
359391007403	tellurite resistance protein terB; Region: terB; cd07176
359391007404	putative metal binding site [ion binding]; other site
359391007405	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
359391007406	active site clefts [active]
359391007407	zinc binding site [ion binding]; other site
359391007408	dimer interface [polypeptide binding]; other site
359391007409	Eukaryotic translation initiation factor 3 subunit 8 N-terminus; Region: eIF-3c_N; pfam05470
359391007410	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
359391007411	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517
359391007412	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
359391007413	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391007414	dimer interface [polypeptide binding]; other site
359391007415	conserved gate region; other site
359391007416	putative PBP binding loops; other site
359391007417	ABC-ATPase subunit interface; other site
359391007418	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
359391007419	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391007420	dimer interface [polypeptide binding]; other site
359391007421	conserved gate region; other site
359391007422	putative PBP binding loops; other site
359391007423	ABC-ATPase subunit interface; other site
359391007424	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
359391007425	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
359391007426	Walker A/P-loop; other site
359391007427	ATP binding site [chemical binding]; other site
359391007428	Q-loop/lid; other site
359391007429	ABC transporter signature motif; other site
359391007430	Walker B; other site
359391007431	D-loop; other site
359391007432	H-loop/switch region; other site
359391007433	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
359391007434	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
359391007435	Walker A/P-loop; other site
359391007436	ATP binding site [chemical binding]; other site
359391007437	Q-loop/lid; other site
359391007438	ABC transporter signature motif; other site
359391007439	Walker B; other site
359391007440	D-loop; other site
359391007441	H-loop/switch region; other site
359391007442	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
359391007443	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
359391007444	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126
359391007445	Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748
359391007446	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
359391007447	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
359391007448	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
359391007449	homodimer interface [polypeptide binding]; other site
359391007450	NADP binding site [chemical binding]; other site
359391007451	substrate binding site [chemical binding]; other site
359391007452	phosphogluconate dehydratase; Validated; Region: PRK09054
359391007453	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
359391007454	putative active site [active]
359391007455	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
359391007456	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
359391007457	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
359391007458	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345
359391007459	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
359391007460	putative NAD(P) binding site [chemical binding]; other site
359391007461	active site
359391007462	drug efflux system protein MdtG; Provisional; Region: PRK09874
359391007463	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
359391007464	putative substrate translocation pore; other site
359391007465	Predicted membrane protein [Function unknown]; Region: COG4541
359391007466	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
359391007467	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
359391007468	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
359391007469	putative DNA binding site [nucleotide binding]; other site
359391007470	putative Zn2+ binding site [ion binding]; other site
359391007471	AsnC family; Region: AsnC_trans_reg; pfam01037
359391007472	Hint domain; Region: Hint_2; pfam13403
359391007473	Transcriptional regulators [Transcription]; Region: MarR; COG1846
359391007474	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
359391007475	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
359391007476	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
359391007477	hypothetical protein; Reviewed; Region: PRK12275
359391007478	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
359391007479	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
359391007480	Domain of unknown function (DUF1127); Region: DUF1127; pfam06568
359391007481	Transcriptional regulator [Transcription]; Region: LysR; COG0583
359391007482	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
359391007483	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
359391007484	dimerization interface [polypeptide binding]; other site
359391007485	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
359391007486	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
359391007487	generic binding surface II; other site
359391007488	generic binding surface I; other site
359391007489	Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572
359391007490	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
359391007491	Transcriptional regulators [Transcription]; Region: MarR; COG1846
359391007492	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
359391007493	dimerization interface [polypeptide binding]; other site
359391007494	putative DNA binding site [nucleotide binding]; other site
359391007495	putative Zn2+ binding site [ion binding]; other site
359391007496	Fusaric acid resistance protein-like; Region: FUSC_2; cl19401
359391007497	Fusaric acid resistance protein family; Region: FUSC; pfam04632
359391007498	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
359391007499	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
359391007500	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
359391007501	HlyD family secretion protein; Region: HlyD_3; pfam13437
359391007502	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
359391007503	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
359391007504	putative ligand binding residues [chemical binding]; other site
359391007505	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
359391007506	ABC-ATPase subunit  interface; other site
359391007507	dimer interface [polypeptide binding]; other site
359391007508	putative PBP binding regions; other site
359391007509	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
359391007510	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
359391007511	Walker A/P-loop; other site
359391007512	ATP binding site [chemical binding]; other site
359391007513	Q-loop/lid; other site
359391007514	ABC transporter signature motif; other site
359391007515	Walker B; other site
359391007516	D-loop; other site
359391007517	H-loop/switch region; other site
359391007518	Uncharacterized conserved protein [Function unknown]; Region: COG5476
359391007519	Protein of unknown function (DUF1485); Region: DUF1485; pfam07364
359391007520	MlrC C-terminus; Region: MlrC_C; pfam07171
359391007521	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
359391007522	homotrimer interaction site [polypeptide binding]; other site
359391007523	putative active site [active]
359391007524	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
359391007525	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391007526	dimer interface [polypeptide binding]; other site
359391007527	conserved gate region; other site
359391007528	putative PBP binding loops; other site
359391007529	ABC-ATPase subunit interface; other site
359391007530	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
359391007531	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391007532	dimer interface [polypeptide binding]; other site
359391007533	conserved gate region; other site
359391007534	putative PBP binding loops; other site
359391007535	ABC-ATPase subunit interface; other site
359391007536	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
359391007537	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
359391007538	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
359391007539	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
359391007540	NAD(P) binding site [chemical binding]; other site
359391007541	active site
359391007542	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
359391007543	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
359391007544	Walker A/P-loop; other site
359391007545	ATP binding site [chemical binding]; other site
359391007546	Q-loop/lid; other site
359391007547	ABC transporter signature motif; other site
359391007548	Walker B; other site
359391007549	D-loop; other site
359391007550	H-loop/switch region; other site
359391007551	TOBE domain; Region: TOBE_2; pfam08402
359391007552	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
359391007553	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
359391007554	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
359391007555	putative active site [active]
359391007556	amino acid processing enzyme-related protein
359391007557	Protein of unknown function UPF0001
359391007558	conserved hypothetical protein
359391007559	conserved hypothetical protein
359391007560	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
359391007561	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
359391007562	Walker A/P-loop; other site
359391007563	ATP binding site [chemical binding]; other site
359391007564	Q-loop/lid; other site
359391007565	ABC transporter signature motif; other site
359391007566	Walker B; other site
359391007567	D-loop; other site
359391007568	H-loop/switch region; other site
359391007569	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
359391007570	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391007571	dimer interface [polypeptide binding]; other site
359391007572	conserved gate region; other site
359391007573	putative PBP binding loops; other site
359391007574	ABC-ATPase subunit interface; other site
359391007575	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
359391007576	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
359391007577	EamA-like transporter family; Region: EamA; pfam00892
359391007578	BA14K-like protein; Region: BA14K; pfam07886
359391007579	Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192
359391007580	putative active site [active]
359391007581	metal binding site [ion binding]; metal-binding site
359391007582	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
359391007583	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
359391007584	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
359391007585	Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931
359391007586	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
359391007587	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
359391007588	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
359391007589	putative active site [active]
359391007590	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
359391007591	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
359391007592	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
359391007593	Reductase C-terminal; Region: Reductase_C; pfam14759
359391007594	Domain of unknown function (DUF1127); Region: DUF1127; cl02276
359391007595	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
359391007596	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
359391007597	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
359391007598	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
359391007599	lipoyl attachment site [posttranslational modification]; other site
359391007600	glycine dehydrogenase; Provisional; Region: PRK05367
359391007601	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
359391007602	tetramer interface [polypeptide binding]; other site
359391007603	pyridoxal 5'-phosphate binding site [chemical binding]; other site
359391007604	catalytic residue [active]
359391007605	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
359391007606	tetramer interface [polypeptide binding]; other site
359391007607	pyridoxal 5'-phosphate binding site [chemical binding]; other site
359391007608	catalytic residue [active]
359391007609	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
359391007610	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
359391007611	putative DNA binding site [nucleotide binding]; other site
359391007612	putative Zn2+ binding site [ion binding]; other site
359391007613	AsnC family; Region: AsnC_trans_reg; pfam01037
359391007614	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905
359391007615	Bombinin; Region: Bombinin; pfam05298
359391007616	DNA-binding domain of Proline dehydrogenase; Region: Pro_dh-DNA_bdg; pfam14850
359391007617	Proline dehydrogenase; Region: Pro_dh; pfam01619
359391007618	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
359391007619	Glutamate binding site [chemical binding]; other site
359391007620	NAD binding site [chemical binding]; other site
359391007621	catalytic residues [active]
359391007622	2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate binding protein; Region: PhnS; TIGR03227
359391007623	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
359391007624	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
359391007625	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391007626	dimer interface [polypeptide binding]; other site
359391007627	conserved gate region; other site
359391007628	putative PBP binding loops; other site
359391007629	ABC-ATPase subunit interface; other site
359391007630	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391007631	dimer interface [polypeptide binding]; other site
359391007632	conserved gate region; other site
359391007633	putative PBP binding loops; other site
359391007634	ABC-ATPase subunit interface; other site
359391007635	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
359391007636	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
359391007637	Walker A/P-loop; other site
359391007638	ATP binding site [chemical binding]; other site
359391007639	Q-loop/lid; other site
359391007640	ABC transporter signature motif; other site
359391007641	Walker B; other site
359391007642	D-loop; other site
359391007643	H-loop/switch region; other site
359391007644	TOBE domain; Region: TOBE_2; pfam08402
359391007645	Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643
359391007646	active site
359391007647	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
359391007648	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
359391007649	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
359391007650	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
359391007651	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
359391007652	PYR/PP interface [polypeptide binding]; other site
359391007653	dimer interface [polypeptide binding]; other site
359391007654	TPP binding site [chemical binding]; other site
359391007655	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
359391007656	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
359391007657	TPP-binding site [chemical binding]; other site
359391007658	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
359391007659	substrate binding site [chemical binding]; other site
359391007660	ATP binding site [chemical binding]; other site
359391007661	Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863
359391007662	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
359391007663	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
359391007664	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
359391007665	putative active site [active]
359391007666	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
359391007667	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
359391007668	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
359391007669	Protein of unknown function (DUF1612); Region: DUF1612; pfam07756
359391007670	HTH DNA binding domain; Region: HTH_13; pfam11972
359391007671	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
359391007672	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
359391007673	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
359391007674	dimerization interface [polypeptide binding]; other site
359391007675	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
359391007676	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
359391007677	dimer interface [polypeptide binding]; other site
359391007678	decamer (pentamer of dimers) interface [polypeptide binding]; other site
359391007679	catalytic triad [active]
359391007680	peroxidatic and resolving cysteines [active]
359391007681	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
359391007682	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
359391007683	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
359391007684	metabolite-proton symporter; Region: 2A0106; TIGR00883
359391007685	putative substrate translocation pore; other site
359391007686	multicopper oxidase; Provisional; Region: PRK10965
359391007687	The first Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_1_CueO_FtsP; cd04232
359391007688	Domain 2 interface [polypeptide binding]; other site
359391007689	Domain 3 interface [polypeptide binding]; other site
359391007690	trinuclear Cu binding site [ion binding]; other site
359391007691	The second Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_2_CueO_FtsP; cd13867
359391007692	Domain 1 interface [polypeptide binding]; other site
359391007693	Domain 3 interface [polypeptide binding]; other site
359391007694	The third Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_3_CueO_FtsP; cd13890
359391007695	Domain 2 interface [polypeptide binding]; other site
359391007696	Domain 1 interface [polypeptide binding]; other site
359391007697	Type 1 (T1) Cu binding site [ion binding]; other site
359391007698	trinuclear Cu binding site [ion binding]; other site
359391007699	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
359391007700	E-class dimer interface [polypeptide binding]; other site
359391007701	P-class dimer interface [polypeptide binding]; other site
359391007702	active site
359391007703	Cu2+ binding site [ion binding]; other site
359391007704	Zn2+ binding site [ion binding]; other site
359391007705	D-amino acid oxidase family protein
359391007706	NAD binding site
359391007707	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
359391007708	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
359391007709	Walker A/P-loop; other site
359391007710	ATP binding site [chemical binding]; other site
359391007711	Q-loop/lid; other site
359391007712	ABC transporter signature motif; other site
359391007713	Walker B; other site
359391007714	D-loop; other site
359391007715	H-loop/switch region; other site
359391007716	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
359391007717	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
359391007718	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391007719	dimer interface [polypeptide binding]; other site
359391007720	conserved gate region; other site
359391007721	putative PBP binding loops; other site
359391007722	ABC-ATPase subunit interface; other site
359391007723	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391007724	dimer interface [polypeptide binding]; other site
359391007725	conserved gate region; other site
359391007726	putative PBP binding loops; other site
359391007727	ABC-ATPase subunit interface; other site
359391007728	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3453
359391007729	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
359391007730	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-II; Region: Lumazine_synthase-II; cd09208
359391007731	active site
359391007732	homopentamer interface [polypeptide binding]; other site
359391007733	dimer interface [polypeptide binding]; other site
359391007734	Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435
359391007735	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
359391007736	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
359391007737	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
359391007738	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391007739	dimer interface [polypeptide binding]; other site
359391007740	conserved gate region; other site
359391007741	putative PBP binding loops; other site
359391007742	ABC-ATPase subunit interface; other site
359391007743	sugar ABC transporter, permease protein, putative KO: K02026 multiple sugar/glycerol-3P transport system permease...
359391007744	Binding-protein-dependent transport systems inner membrane component:Prion protein
359391007745	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
359391007746	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
359391007747	Walker A/P-loop; other site
359391007748	ATP binding site [chemical binding]; other site
359391007749	Q-loop/lid; other site
359391007750	ABC transporter signature motif; other site
359391007751	Walker B; other site
359391007752	D-loop; other site
359391007753	H-loop/switch region; other site
359391007754	TOBE domain; Region: TOBE_2; pfam08402
359391007755	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
359391007756	putative transporter; Provisional; Region: PRK10504
359391007757	putative substrate translocation pore; other site
359391007758	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
359391007759	S-adenosylmethionine binding site [chemical binding]; other site
359391007760	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
359391007761	Ppx/GppA phosphatase family; Region: Ppx-GppA; cl19483
359391007762	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
359391007763	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
359391007764	Walker A/P-loop; other site
359391007765	ATP binding site [chemical binding]; other site
359391007766	Q-loop/lid; other site
359391007767	ABC transporter signature motif; other site
359391007768	Walker B; other site
359391007769	D-loop; other site
359391007770	H-loop/switch region; other site
359391007771	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
359391007772	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391007773	dimer interface [polypeptide binding]; other site
359391007774	conserved gate region; other site
359391007775	putative PBP binding loops; other site
359391007776	ABC-ATPase subunit interface; other site
359391007777	cystine transporter subunit; Provisional; Region: PRK11260
359391007778	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
359391007779	substrate binding pocket [chemical binding]; other site
359391007780	membrane-bound complex binding site; other site
359391007781	hinge residues; other site
359391007782	5-oxoprolinase; Region: PLN02666
359391007783	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
359391007784	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
359391007785	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
359391007786	Predicted transcription regulator, contains HTH domain (MarR family) [Transcription]; Region: COG5631
359391007787	Transcriptional regulators [Transcription]; Region: MarR; COG1846
359391007788	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
359391007789	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
359391007790	Walker A/P-loop; other site
359391007791	ATP binding site [chemical binding]; other site
359391007792	Q-loop/lid; other site
359391007793	ABC transporter signature motif; other site
359391007794	Walker B; other site
359391007795	D-loop; other site
359391007796	H-loop/switch region; other site
359391007797	ABC-type enterochelin transport system, permease component [Inorganic ion transport and metabolism]; Region: CeuC; COG4605
359391007798	ABC-ATPase subunit  interface; other site
359391007799	dimer interface [polypeptide binding]; other site
359391007800	putative PBP binding regions; other site
359391007801	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
359391007802	ABC-ATPase subunit  interface; other site
359391007803	dimer interface [polypeptide binding]; other site
359391007804	putative PBP binding regions; other site
359391007805	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
359391007806	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
359391007807	putative ligand binding residues [chemical binding]; other site
359391007808	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
359391007809	NAD binding site [chemical binding]; other site
359391007810	catalytic residues [active]
359391007811	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237
359391007812	Protein of unknown function (DUF3775); Region: DUF3775; pfam12616
359391007813	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
359391007814	Predicted oxidoreductase [General function prediction only]; Region: COG3573
359391007815	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
359391007816	aminotransferase; Provisional; Region: PRK13356
359391007817	homodimer interface [polypeptide binding]; other site
359391007818	substrate-cofactor binding pocket; other site
359391007819	pyridoxal 5'-phosphate binding site [chemical binding]; other site
359391007820	catalytic residue [active]
359391007821	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
359391007822	EamA-like transporter family; Region: EamA; pfam00892
359391007823	Domain of unknown function (DUF1127); Region: DUF1127; pfam06568
359391007824	Protein of unknown function (DUF2938); Region: DUF2938; pfam11158
359391007825	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
359391007826	Sulfate transporter family; Region: Sulfate_transp; cl19250
359391007827	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
359391007828	nucleoside/Zn binding site; other site
359391007829	dimer interface [polypeptide binding]; other site
359391007830	catalytic motif [active]
359391007831	TrkA-C
359391007832	hypothetical
359391007833	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
359391007834	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
359391007835	Walker A/P-loop; other site
359391007836	ATP binding site [chemical binding]; other site
359391007837	Q-loop/lid; other site
359391007838	ABC transporter signature motif; other site
359391007839	Walker B; other site
359391007840	D-loop; other site
359391007841	H-loop/switch region; other site
359391007842	TOBE domain; Region: TOBE_2; pfam08402
359391007843	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
359391007844	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391007845	dimer interface [polypeptide binding]; other site
359391007846	conserved gate region; other site
359391007847	putative PBP binding loops; other site
359391007848	ABC-ATPase subunit interface; other site
359391007849	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
359391007850	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
359391007851	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391007852	dimer interface [polypeptide binding]; other site
359391007853	conserved gate region; other site
359391007854	putative PBP binding loops; other site
359391007855	ABC-ATPase subunit interface; other site
359391007856	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
359391007857	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
359391007858	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
359391007859	active site
359391007860	dimer interface [polypeptide binding]; other site
359391007861	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
359391007862	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
359391007863	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
359391007864	active site
359391007865	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
359391007866	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
359391007867	Walker A/P-loop; other site
359391007868	ATP binding site [chemical binding]; other site
359391007869	Q-loop/lid; other site
359391007870	ABC transporter signature motif; other site
359391007871	Walker B; other site
359391007872	D-loop; other site
359391007873	H-loop/switch region; other site
359391007874	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
359391007875	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
359391007876	Walker A/P-loop; other site
359391007877	ATP binding site [chemical binding]; other site
359391007878	Q-loop/lid; other site
359391007879	ABC transporter signature motif; other site
359391007880	Walker B; other site
359391007881	D-loop; other site
359391007882	H-loop/switch region; other site
359391007883	Bacterial inner-membrane translocator
359391007884	branched-chain amino acid ABC transporter, permease protein
359391007885	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
359391007886	TM-ABC transporter signature motif; other site
359391007887	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
359391007888	3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK05975
359391007889	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
359391007890	tetramer interface [polypeptide binding]; other site
359391007891	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
359391007892	Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463
359391007893	heterodimer interface [polypeptide binding]; other site
359391007894	active site
359391007895	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
359391007896	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
359391007897	active site
359391007898	4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425
359391007899	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
359391007900	Putative lysophospholipase; Region: Hydrolase_4; cl19140
359391007901	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
359391007902	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
359391007903	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
359391007904	dimerization interface [polypeptide binding]; other site
359391007905	p-hydroxybenzoate hydroxylase
359391007906	NAD binding site:Flavoprotein monooxygenase:Pyridine nucleotide-disulphide oxidoreductase, class I:FAD-dependent pyridine nuc...
359391007907	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
359391007908	Cupin domain; Region: Cupin_2; cl17218
359391007909	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
359391007910	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
359391007911	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
359391007912	Bacterial transcriptional regulator; Region: IclR; pfam01614
359391007913	3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429
359391007914	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
359391007915	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
359391007916	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
359391007917	dimer interface [polypeptide binding]; other site
359391007918	active site
359391007919	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
359391007920	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
359391007921	active site
359391007922	transcriptional regulator, AsnC family
359391007923	Bacterial regulatory proteins, AsnC family
359391007924	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
359391007925	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
359391007926	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
359391007927	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
359391007928	substrate binding pocket [chemical binding]; other site
359391007929	membrane-bound complex binding site; other site
359391007930	hinge residues; other site
359391007931	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
359391007932	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
359391007933	substrate binding pocket [chemical binding]; other site
359391007934	membrane-bound complex binding site; other site
359391007935	hinge residues; other site
359391007936	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
359391007937	FAD dependent oxidoreductase; Region: DAO; pfam01266
359391007938	Helix-turn-helix, AraC type
359391007939	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
359391007940	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
359391007941	active site
359391007942	catalytic site [active]
359391007943	substrate binding site [chemical binding]; other site
359391007944	Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013
359391007945	GGDEF domain protein
359391007946	GGDEF
359391007947	Uncharacterized conserved protein [Function unknown]; Region: COG3391
359391007948	SdiA-regulated; Region: SdiA-regulated; cl19046
359391007949	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
359391007950	DNA polymerase IV; Provisional; Region: PRK02794
359391007951	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
359391007952	active site
359391007953	DNA binding site [nucleotide binding]
359391007954	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
359391007955	Rnk N-terminus; Region: Rnk_N; pfam14760
359391007956	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
359391007957	Protein of unknown function (DUF3572); Region: DUF3572; pfam12096
359391007958	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
359391007959	active site
359391007960	phosphorylation site [posttranslational modification]
359391007961	intermolecular recognition site; other site
359391007962	dimerization interface [polypeptide binding]; other site
359391007963	response regulator PleD; Reviewed; Region: pleD; PRK09581
359391007964	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
359391007965	active site
359391007966	phosphorylation site [posttranslational modification]
359391007967	intermolecular recognition site; other site
359391007968	dimerization interface [polypeptide binding]; other site
359391007969	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
359391007970	active site
359391007971	phosphorylation site [posttranslational modification]
359391007972	dimerization interface [polypeptide binding]; other site
359391007973	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
359391007974	metal binding site [ion binding]; metal-binding site
359391007975	active site
359391007976	I-site; other site
359391007977	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
359391007978	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
359391007979	Major Facilitator Superfamily; Region: MFS_1; pfam07690
359391007980	putative substrate translocation pore; other site
359391007981	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
359391007982	nudix motif; other site
359391007983	hypothetical protein; Provisional; Region: PRK05978
359391007984	ribonuclease R; Region: RNase_R; TIGR02063
359391007985	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
359391007986	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
359391007987	RNA binding site [nucleotide binding]; other site
359391007988	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
359391007989	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
359391007990	active site
359391007991	interdomain interaction site; other site
359391007992	putative metal-binding site [ion binding]; other site
359391007993	nucleotide binding site [chemical binding]; other site
359391007994	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
359391007995	domain I; other site
359391007996	DNA binding groove [nucleotide binding]
359391007997	phosphate binding site [ion binding]; other site
359391007998	domain II; other site
359391007999	domain III; other site
359391008000	nucleotide binding site [chemical binding]; other site
359391008001	catalytic site [active]
359391008002	domain IV; other site
359391008003	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
359391008004	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
359391008005	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
359391008006	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
359391008007	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
359391008008	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
359391008009	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
359391008010	dihydroorotase; Validated; Region: PRK09059
359391008011	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
359391008012	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
359391008013	active site
359391008014	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
359391008015	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
359391008016	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
359391008017	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
359391008018	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
359391008019	active site
359391008020	Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816
359391008021	metal-dependent hydrolase; Provisional; Region: PRK00685
359391008022	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
359391008023	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
359391008024	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
359391008025	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
359391008026	ATP binding site [chemical binding]; other site
359391008027	Mg2+ binding site [ion binding]; other site
359391008028	G-X-G motif; other site
359391008029	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
359391008030	anchoring element; other site
359391008031	dimer interface [polypeptide binding]; other site
359391008032	ATP binding site [chemical binding]; other site
359391008033	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
359391008034	active site
359391008035	metal binding site [ion binding]; metal-binding site
359391008036	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
359391008037	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
359391008038	EamA-like transporter family; Region: EamA; pfam00892
359391008039	lipoate-protein ligase B; Provisional; Region: PRK14341
359391008040	PAS domain; Region: PAS_9; pfam13426
359391008041	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
359391008042	putative active site [active]
359391008043	heme pocket [chemical binding]; other site
359391008044	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
359391008045	PAS fold; Region: PAS_3; pfam08447
359391008046	putative active site [active]
359391008047	heme pocket [chemical binding]; other site
359391008048	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
359391008049	HWE histidine kinase; Region: HWE_HK; pfam07536
359391008050	BA14K-like protein; Region: BA14K; pfam07886
359391008051	Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946
359391008052	Bacterial virulence protein (VirJ); Region: VirJ; pfam06057
359391008053	Predicted integral membrane protein [Function unknown]; Region: COG0392
359391008054	Uncharacterized conserved protein [Function unknown]; Region: COG2898
359391008055	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
359391008056	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
359391008057	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353
359391008058	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
359391008059	Substrate binding site; other site
359391008060	Mg++ binding site; other site
359391008061	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
359391008062	active site
359391008063	substrate binding site [chemical binding]; other site
359391008064	CoA binding site [chemical binding]; other site
359391008065	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
359391008066	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
359391008067	glutaminase active site [active]
359391008068	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
359391008069	dimer interface [polypeptide binding]; other site
359391008070	active site
359391008071	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
359391008072	dimer interface [polypeptide binding]; other site
359391008073	active site
359391008074	RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200
359391008075	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
359391008076	generic binding surface II; other site
359391008077	ssDNA binding site; other site
359391008078	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
359391008079	ATP binding site [chemical binding]; other site
359391008080	putative Mg++ binding site [ion binding]; other site
359391008081	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
359391008082	nucleotide binding region [chemical binding]; other site
359391008083	ATP-binding site [chemical binding]; other site
359391008084	Uncharacterized conserved protein [Function unknown]; Region: COG2938
359391008085	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
359391008086	Bifunctional transglycosylase second domain; Region: UB2H; pfam14814
359391008087	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
359391008088	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
359391008089	ATP binding site [chemical binding]; other site
359391008090	putative Mg++ binding site [ion binding]; other site
359391008091	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
359391008092	nucleotide binding region [chemical binding]; other site
359391008093	ATP-binding site [chemical binding]; other site
359391008094	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
359391008095	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
359391008096	active site
359391008097	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
359391008098	catalytic residues [active]
359391008099	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
359391008100	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
359391008101	Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342
359391008102	Uncharacterized conserved protein [Function unknown]; Region: COG3785
359391008103	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494
359391008104	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
359391008105	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
359391008106	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
359391008107	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
359391008108	NADP binding site [chemical binding]; other site
359391008109	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
359391008110	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
359391008111	Walker A/P-loop; other site
359391008112	ATP binding site [chemical binding]; other site
359391008113	Q-loop/lid; other site
359391008114	ABC transporter signature motif; other site
359391008115	Walker B; other site
359391008116	D-loop; other site
359391008117	H-loop/switch region; other site
359391008118	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
359391008119	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
359391008120	TM-ABC transporter signature motif; other site
359391008121	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
359391008122	TM-ABC transporter signature motif; other site
359391008123	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
359391008124	putative ligand binding site [chemical binding]; other site
359391008125	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
359391008126	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
359391008127	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
359391008128	FeS/SAM binding site; other site
359391008129	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
359391008130	Ferritin-like domain; Region: Ferritin; pfam00210
359391008131	heme binding site [chemical binding]; other site
359391008132	ferroxidase pore; other site
359391008133	ferroxidase diiron center [ion binding]; other site
359391008134	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
359391008135	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
359391008136	iron-responsive transcriptional regulator; Reviewed; Region: rirA; PRK11920
359391008137	Rrf2 family protein; Region: rrf2_super; TIGR00738
359391008138	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
359391008139	putative deacylase active site [active]
359391008140	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
359391008141	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
359391008142	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
359391008143	Transposase; Region: HTH_Tnp_1; cl17663
359391008144	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
359391008145	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
359391008146	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
359391008147	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
359391008148	zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005
359391008149	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
359391008150	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
359391008151	yecA family protein; Region: ygfB_yecA; TIGR02292
359391008152	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
359391008153	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
359391008154	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
359391008155	conserved domain protein
359391008156	Protein of unknown function (DUF995); Region: DUF995; pfam06191
359391008157	Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124
359391008158	Protein of unknown function (DUF995); Region: DUF995; pfam06191
359391008159	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
359391008160	UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721
359391008161	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
359391008162	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
359391008163	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
359391008164	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
359391008165	active site
359391008166	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
359391008167	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
359391008168	NAD binding site [chemical binding]; other site
359391008169	homodimer interface [polypeptide binding]; other site
359391008170	active site
359391008171	substrate binding site [chemical binding]; other site
359391008172	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
359391008173	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
359391008174	NAD binding site [chemical binding]; other site
359391008175	putative substrate binding site 2 [chemical binding]; other site
359391008176	putative substrate binding site 1 [chemical binding]; other site
359391008177	active site
359391008178	Predicted integral membrane protein [Function unknown]; Region: COG5455
359391008179	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
359391008180	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
359391008181	peptide binding site [polypeptide binding]; other site
359391008182	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
359391008183	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
359391008184	peptide binding site [polypeptide binding]; other site
359391008185	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
359391008186	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391008187	dimer interface [polypeptide binding]; other site
359391008188	conserved gate region; other site
359391008189	putative PBP binding loops; other site
359391008190	ABC-ATPase subunit interface; other site
359391008191	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
359391008192	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
359391008193	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391008194	dimer interface [polypeptide binding]; other site
359391008195	conserved gate region; other site
359391008196	putative PBP binding loops; other site
359391008197	ABC-ATPase subunit interface; other site
359391008198	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
359391008199	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
359391008200	Walker A/P-loop; other site
359391008201	ATP binding site [chemical binding]; other site
359391008202	Q-loop/lid; other site
359391008203	ABC transporter signature motif; other site
359391008204	Walker B; other site
359391008205	D-loop; other site
359391008206	H-loop/switch region; other site
359391008207	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
359391008208	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
359391008209	Walker A/P-loop; other site
359391008210	ATP binding site [chemical binding]; other site
359391008211	Q-loop/lid; other site
359391008212	ABC transporter signature motif; other site
359391008213	Walker B; other site
359391008214	D-loop; other site
359391008215	H-loop/switch region; other site
359391008216	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
359391008217	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
359391008218	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
359391008219	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
359391008220	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
359391008221	benzoate transport; Region: 2A0115; TIGR00895
359391008222	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
359391008223	putative substrate translocation pore; other site
359391008224	L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253
359391008225	homodimer interface [polypeptide binding]; other site
359391008226	homotetramer interface [polypeptide binding]; other site
359391008227	active site pocket [active]
359391008228	cleavage site
359391008229	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
359391008230	AAA-like domain; Region: AAA_10; pfam12846
359391008231	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
359391008232	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
359391008233	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
359391008234	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
359391008235	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
359391008236	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
359391008237	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
359391008238	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
359391008239	E3 interaction surface; other site
359391008240	lipoyl attachment site [posttranslational modification]; other site
359391008241	e3 binding domain; Region: E3_binding; pfam02817
359391008242	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
359391008243	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
359391008244	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
359391008245	alpha subunit interface [polypeptide binding]; other site
359391008246	TPP binding site [chemical binding]; other site
359391008247	heterodimer interface [polypeptide binding]; other site
359391008248	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
359391008249	2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573
359391008250	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
359391008251	tetramer interface [polypeptide binding]; other site
359391008252	TPP-binding site [chemical binding]; other site
359391008253	heterodimer interface [polypeptide binding]; other site
359391008254	phosphorylation loop region [posttranslational modification]
359391008255	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
359391008256	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
359391008257	Walker A/P-loop; other site
359391008258	ATP binding site [chemical binding]; other site
359391008259	Q-loop/lid; other site
359391008260	ABC transporter signature motif; other site
359391008261	Walker B; other site
359391008262	D-loop; other site
359391008263	H-loop/switch region; other site
359391008264	TOBE domain; Region: TOBE_2; pfam08402
359391008265	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
359391008266	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
359391008267	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
359391008268	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391008269	dimer interface [polypeptide binding]; other site
359391008270	conserved gate region; other site
359391008271	putative PBP binding loops; other site
359391008272	ABC-ATPase subunit interface; other site
359391008273	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
359391008274	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391008275	dimer interface [polypeptide binding]; other site
359391008276	conserved gate region; other site
359391008277	putative PBP binding loops; other site
359391008278	ABC-ATPase subunit interface; other site
359391008279	sugar-binding protein KO: K02027 multiple sugar/glycerol-3P transport system substrate-binding protein
359391008280	sugar ABC transporter, periplasmic sugar-binding protein KO: K02027 multiple sugar/glycerol-3P transport system...
359391008281	Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971
359391008282	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
359391008283	nucleotide binding site [chemical binding]; other site
359391008284	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
359391008285	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
359391008286	DNA-binding site [nucleotide binding]; DNA binding site
359391008287	UTRA domain; Region: UTRA; pfam07702
359391008288	Predicted outer membrane lipoprotein [Function unknown]; Region: COG4890
359391008289	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
359391008290	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
359391008291	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
359391008292	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
359391008293	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
359391008294	Walker A/P-loop; other site
359391008295	ATP binding site [chemical binding]; other site
359391008296	Q-loop/lid; other site
359391008297	ABC transporter signature motif; other site
359391008298	Walker B; other site
359391008299	D-loop; other site
359391008300	H-loop/switch region; other site
359391008301	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
359391008302	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
359391008303	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
359391008304	Walker A/P-loop; other site
359391008305	ATP binding site [chemical binding]; other site
359391008306	Q-loop/lid; other site
359391008307	ABC transporter signature motif; other site
359391008308	Walker B; other site
359391008309	D-loop; other site
359391008310	H-loop/switch region; other site
359391008311	Predicted transcriptional regulators [Transcription]; Region: COG1510
359391008312	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
359391008313	dimerization interface [polypeptide binding]; other site
359391008314	putative DNA binding site [nucleotide binding]; other site
359391008315	putative Zn2+ binding site [ion binding]; other site
359391008316	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12671
359391008317	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161
359391008318	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12596
359391008319	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
359391008320	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
359391008321	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094
359391008322	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
359391008323	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
359391008324	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
359391008325	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
359391008326	monovalent cation:proton antiporter; Region: 2a6301s02; TIGR00943
359391008327	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
359391008328	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
359391008329	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
359391008330	dimer interface [polypeptide binding]; other site
359391008331	FMN binding site [chemical binding]; other site
359391008332	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
359391008333	MPT binding site; other site
359391008334	trimer interface [polypeptide binding]; other site
359391008335	biotin synthase; Region: bioB; TIGR00433
359391008336	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
359391008337	FeS/SAM binding site; other site
359391008338	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
359391008339	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
359391008340	8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858
359391008341	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
359391008342	catalytic residue [active]
359391008343	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
359391008344	AAA domain; Region: AAA_26; pfam13500
359391008345	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
359391008346	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
359391008347	inhibitor-cofactor binding pocket; inhibition site
359391008348	pyridoxal 5'-phosphate binding site [chemical binding]; other site
359391008349	catalytic residue [active]
359391008350	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05963
359391008351	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
359391008352	dimer interface [polypeptide binding]; other site
359391008353	active site
359391008354	CoA binding pocket [chemical binding]; other site
359391008355	conserved hypothetical protein
359391008356	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
359391008357	proposed active site lysine [active]
359391008358	conserved cys residue [active]
359391008359	Glycoside hydrolase, family 25
359391008360	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
359391008361	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
359391008362	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
359391008363	Transcriptional regulators [Transcription]; Region: MarR; COG1846
359391008364	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
359391008365	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
359391008366	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
359391008367	Uncharacterized conserved protein [Function unknown]; Region: COG3189
359391008368	sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101
359391008369	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
359391008370	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
359391008371	active site
359391008372	phosphorylation site [posttranslational modification]
359391008373	intermolecular recognition site; other site
359391008374	dimerization interface [polypeptide binding]; other site
359391008375	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
359391008376	DNA binding site [nucleotide binding]
359391008377	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
359391008378	HAMP domain; Region: HAMP; pfam00672
359391008379	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
359391008380	dimer interface [polypeptide binding]; other site
359391008381	phosphorylation site [posttranslational modification]
359391008382	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
359391008383	ATP binding site [chemical binding]; other site
359391008384	Mg2+ binding site [ion binding]; other site
359391008385	G-X-G motif; other site
359391008386	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
359391008387	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
359391008388	HlyD family secretion protein; Region: HlyD_3; pfam13437
359391008389	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
359391008390	putative substrate translocation pore; other site
359391008391	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
359391008392	Transcriptional regulators [Transcription]; Region: MarR; COG1846
359391008393	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
359391008394	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
359391008395	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
359391008396	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
359391008397	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
359391008398	Walker A/P-loop; other site
359391008399	ATP binding site [chemical binding]; other site
359391008400	Q-loop/lid; other site
359391008401	ABC transporter signature motif; other site
359391008402	Walker B; other site
359391008403	D-loop; other site
359391008404	H-loop/switch region; other site
359391008405	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
359391008406	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391008407	dimer interface [polypeptide binding]; other site
359391008408	conserved gate region; other site
359391008409	putative PBP binding loops; other site
359391008410	ABC-ATPase subunit interface; other site
359391008411	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
359391008412	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580
359391008413	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
359391008414	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
359391008415	ATP/GTP-binding site motif A (P-loop):ABC transporter
359391008416	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
359391008417	Peptidase family M23; Region: Peptidase_M23; pfam01551
359391008418	HlyD family secretion protein; Region: HlyD_3; pfam13437
359391008419	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552
359391008420	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
359391008421	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
359391008422	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
359391008423	Transcriptional regulators [Transcription]; Region: GntR; COG1802
359391008424	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
359391008425	DNA-binding site [nucleotide binding]; DNA binding site
359391008426	FCD domain; Region: FCD; pfam07729
359391008427	Predicted transporter component [General function prediction only]; Region: COG2391
359391008428	Sulphur transport; Region: Sulf_transp; pfam04143
359391008429	Predicted transporter component [General function prediction only]; Region: COG2391
359391008430	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
359391008431	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
359391008432	dimerization interface [polypeptide binding]; other site
359391008433	putative DNA binding site [nucleotide binding]; other site
359391008434	putative Zn2+ binding site [ion binding]; other site
359391008435	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354
359391008436	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
359391008437	active site
359391008438	catalytic residues [active]
359391008439	metal binding site [ion binding]; metal-binding site
359391008440	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
359391008441	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
359391008442	ligand binding site [chemical binding]; other site
359391008443	NAD binding site [chemical binding]; other site
359391008444	tetramer interface [polypeptide binding]; other site
359391008445	catalytic site [active]
359391008446	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
359391008447	L-serine binding site [chemical binding]; other site
359391008448	ACT domain interface; other site
359391008449	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
359391008450	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
359391008451	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
359391008452	AMP-dependent synthetase and ligase
359391008453	acetyl-coenzyme A synthetase
359391008454	possible 3-hydroxyacyl-CoA dehydrogenase, putative
359391008455	Short-chain dehydrogenase/reductase SDR:Glucose/ribitol dehydrogenase
359391008456	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
359391008457	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
359391008458	dimer interface [polypeptide binding]; other site
359391008459	active site
359391008460	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
359391008461	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
359391008462	active site
359391008463	methionine sulfoxide reductase B; Provisional; Region: PRK00222
359391008464	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
359391008465	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
359391008466	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
359391008467	putative dimerization interface [polypeptide binding]; other site
359391008468	putative substrate binding pocket [chemical binding]; other site
359391008469	Sugar transporter superfamily:Major facilitator superfamily (MFS)
359391008470	multidrug resistance protein
359391008471	glycerol kinase
359391008472	Carbohydrate kinase, FGGY
359391008473	hypothetical
359391008474	uracil permease
359391008475	Xanthine/uracil/vitamin C permease family
359391008476	conserved hypothetical protein
359391008477	fucose synthetase family protein
359391008478	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
359391008479	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
359391008480	SLBB domain; Region: SLBB; pfam10531
359391008481	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
359391008482	Chain length determinant protein; Region: Wzz; pfam02706
359391008483	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
359391008484	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
359391008485	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078
359391008486	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
359391008487	DNA binding residues [nucleotide binding]
359391008488	dimerization interface [polypeptide binding]; other site
359391008489	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
359391008490	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
359391008491	ligand binding site [chemical binding]; other site
359391008492	flexible hinge region; other site
359391008493	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
359391008494	putative switch regulator; other site
359391008495	non-specific DNA interactions [nucleotide binding]; other site
359391008496	DNA binding site [nucleotide binding]
359391008497	sequence specific DNA binding site [nucleotide binding]; other site
359391008498	putative cAMP binding site [chemical binding]; other site
359391008499	N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131
359391008500	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
359391008501	putative active site cavity [active]
359391008502	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
359391008503	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
359391008504	nucleotide binding site [chemical binding]; other site
359391008505	Transcriptional regulators [Transcription]; Region: FadR; COG2186
359391008506	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
359391008507	DNA-binding site [nucleotide binding]; DNA binding site
359391008508	FCD domain; Region: FCD; pfam07729
359391008509	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
359391008510	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
359391008511	peptide ABC transporter, permease protein KO: K02033 peptide transport system permease protein
359391008512	Binding-protein-dependent transport systems inner membrane component
359391008513	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
359391008514	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
359391008515	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391008516	dimer interface [polypeptide binding]; other site
359391008517	conserved gate region; other site
359391008518	putative PBP binding loops; other site
359391008519	ABC-ATPase subunit interface; other site
359391008520	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
359391008521	inhibitor site; inhibition site
359391008522	active site
359391008523	dimer interface [polypeptide binding]; other site
359391008524	catalytic residue [active]
359391008525	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
359391008526	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
359391008527	Walker A/P-loop; other site
359391008528	ATP binding site [chemical binding]; other site
359391008529	Q-loop/lid; other site
359391008530	ABC transporter signature motif; other site
359391008531	Walker B; other site
359391008532	D-loop; other site
359391008533	H-loop/switch region; other site
359391008534	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
359391008535	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
359391008536	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
359391008537	Walker A/P-loop; other site
359391008538	ATP binding site [chemical binding]; other site
359391008539	Q-loop/lid; other site
359391008540	ABC transporter signature motif; other site
359391008541	Walker B; other site
359391008542	D-loop; other site
359391008543	H-loop/switch region; other site
359391008544	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
359391008545	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
359391008546	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
359391008547	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
359391008548	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; cl19130
359391008549	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
359391008550	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
359391008551	Zinc-dependent alcohol dehydrogenases (ADH) and class III ADG (AKA formaldehyde dehydrogenase); Region: liver_ADH_like1; cd08281
359391008552	NAD binding site [chemical binding]; other site
359391008553	catalytic Zn binding site [ion binding]; other site
359391008554	substrate binding site [chemical binding]; other site
359391008555	structural Zn binding site [ion binding]; other site
359391008556	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
359391008557	Receptor family ligand binding region; Region: ANF_receptor; pfam01094
359391008558	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
359391008559	tetramerization interface [polypeptide binding]; other site
359391008560	NAD(P) binding site [chemical binding]; other site
359391008561	catalytic residues [active]
359391008562	choline dehydrogenase; Validated; Region: PRK02106
359391008563	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
359391008564	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
359391008565	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
359391008566	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
359391008567	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
359391008568	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
359391008569	shikimate binding site; other site
359391008570	NAD(P) binding site [chemical binding]; other site
359391008571	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
359391008572	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
359391008573	NAD(P) binding site [chemical binding]; other site
359391008574	active site
359391008575	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
359391008576	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
359391008577	Walker A/P-loop; other site
359391008578	ATP binding site [chemical binding]; other site
359391008579	Q-loop/lid; other site
359391008580	ABC transporter signature motif; other site
359391008581	Walker B; other site
359391008582	D-loop; other site
359391008583	H-loop/switch region; other site
359391008584	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
359391008585	TM-ABC transporter signature motif; other site
359391008586	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
359391008587	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
359391008588	Walker A/P-loop; other site
359391008589	ATP binding site [chemical binding]; other site
359391008590	Q-loop/lid; other site
359391008591	ABC transporter signature motif; other site
359391008592	Walker B; other site
359391008593	D-loop; other site
359391008594	H-loop/switch region; other site
359391008595	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
359391008596	TM-ABC transporter signature motif; other site
359391008597	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
359391008598	Receptor family ligand binding region; Region: ANF_receptor; pfam01094
359391008599	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
359391008600	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
359391008601	NAD(P) binding site [chemical binding]; other site
359391008602	Transcriptional regulators [Transcription]; Region: GntR; COG1802
359391008603	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
359391008604	DNA-binding site [nucleotide binding]; DNA binding site
359391008605	FCD domain; Region: FCD; pfam07729
359391008606	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
359391008607	acetate kinase; Provisional; Region: PRK07058
359391008608	putative phosphoketolase; Provisional; Region: PRK05261
359391008609	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
359391008610	TPP-binding site; other site
359391008611	D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894
359391008612	XFP C-terminal domain; Region: XFP_C; pfam09363
359391008613	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
359391008614	4Fe-4S binding domain; Region: Fer4_5; pfam12801
359391008615	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
359391008616	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
359391008617	Uncharacterized protein probably involved in high-affinity Fe2+ transport [Inorganic ion transport and metabolism]; Region: Tpd; COG3470
359391008618	GMP synthase; Reviewed; Region: guaA; PRK00074
359391008619	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
359391008620	AMP/PPi binding site [chemical binding]; other site
359391008621	candidate oxyanion hole; other site
359391008622	catalytic triad [active]
359391008623	potential glutamine specificity residues [chemical binding]; other site
359391008624	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
359391008625	ATP Binding subdomain [chemical binding]; other site
359391008626	Ligand Binding sites [chemical binding]; other site
359391008627	Dimerization subdomain; other site
359391008628	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06026
359391008629	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
359391008630	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
359391008631	CoenzymeA binding site [chemical binding]; other site
359391008632	subunit interaction site [polypeptide binding]; other site
359391008633	PHB binding site; other site
359391008634	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
359391008635	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
359391008636	S-adenosylmethionine binding site [chemical binding]; other site
359391008637	Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495
359391008638	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
359391008639	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
359391008640	tetramer interface [polypeptide binding]; other site
359391008641	heme binding pocket [chemical binding]; other site
359391008642	NADPH binding site [chemical binding]; other site
359391008643	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
359391008644	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
359391008645	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
359391008646	dimerization interface [polypeptide binding]; other site
359391008647	Cytochrome c [Energy production and conversion]; Region: COG3258
359391008648	Cytochrome c; Region: Cytochrom_C; pfam00034
359391008649	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
359391008650	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
359391008651	active site
359391008652	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
359391008653	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
359391008654	putative ion selectivity filter; other site
359391008655	putative pore gating glutamate residue; other site
359391008656	putative H+/Cl- coupling transport residue; other site
359391008657	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
359391008658	putative active site pocket [active]
359391008659	cleavage site
359391008660	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
359391008661	ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088
359391008662	active site
359391008663	substrate binding site [chemical binding]; other site
359391008664	metal binding site [ion binding]; metal-binding site
359391008665	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
359391008666	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
359391008667	Substrate binding site; other site
359391008668	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
359391008669	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
359391008670	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
359391008671	LysR substrate binding domain; Region: LysR_substrate; pfam03466
359391008672	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
359391008673	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
359391008674	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
359391008675	acid-resistance protein; Provisional; Region: PRK10208
359391008676	glutaminase; Reviewed; Region: PRK12356
359391008677	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
359391008678	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
359391008679	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
359391008680	catalytic residue [active]
359391008681	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
359391008682	Predicted membrane protein [Function unknown]; Region: COG4803
359391008683	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
359391008684	Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169
359391008685	HlyD family secretion protein; Region: HlyD_3; pfam13437
359391008686	Acriflavin resistance protein
359391008687	Acriflavin resistance protein
359391008688	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
359391008689	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
359391008690	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391008691	dimer interface [polypeptide binding]; other site
359391008692	conserved gate region; other site
359391008693	putative PBP binding loops; other site
359391008694	ABC-ATPase subunit interface; other site
359391008695	2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050
359391008696	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391008697	dimer interface [polypeptide binding]; other site
359391008698	conserved gate region; other site
359391008699	putative PBP binding loops; other site
359391008700	ABC-ATPase subunit interface; other site
359391008701	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
359391008702	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
359391008703	Walker A/P-loop; other site
359391008704	ATP binding site [chemical binding]; other site
359391008705	Q-loop/lid; other site
359391008706	ABC transporter signature motif; other site
359391008707	Walker B; other site
359391008708	D-loop; other site
359391008709	H-loop/switch region; other site
359391008710	TOBE domain; Region: TOBE_2; pfam08402
359391008711	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
359391008712	Domain of unknown function (DUF3597); Region: DUF3597; pfam12200
359391008713	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
359391008714	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
359391008715	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
359391008716	P-loop; other site
359391008717	ADP binding residues [chemical binding]; other site
359391008718	Switch I; other site
359391008719	Switch II; other site
359391008720	septum formation inhibitor; Reviewed; Region: minC; PRK05177
359391008721	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
359391008722	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
359391008723	dimer interface [polypeptide binding]; other site
359391008724	putative radical transfer pathway; other site
359391008725	diiron center [ion binding]; other site
359391008726	tyrosyl radical; other site
359391008727	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
359391008728	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
359391008729	Class I ribonucleotide reductase; Region: RNR_I; cd01679
359391008730	active site
359391008731	dimer interface [polypeptide binding]; other site
359391008732	catalytic residues [active]
359391008733	effector binding site; other site
359391008734	R2 peptide binding site; other site
359391008735	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
359391008736	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
359391008737	catalytic residues [active]
359391008738	Beta and gamma crystallin:Tetracycline resistance protein:Major facilitator superfamily (MFS)
359391008739	transporter, putative
359391008740	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
359391008741	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
359391008742	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
359391008743	Trehalose utilization protein [Carbohydrate transport and metabolism]; Region: ThuA; COG4813
359391008744	conserved cys residue [active]
359391008745	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
359391008746	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
359391008747	Walker A/P-loop; other site
359391008748	ATP binding site [chemical binding]; other site
359391008749	Q-loop/lid; other site
359391008750	ABC transporter signature motif; other site
359391008751	Walker B; other site
359391008752	D-loop; other site
359391008753	H-loop/switch region; other site
359391008754	TOBE domain; Region: TOBE_2; pfam08402
359391008755	Binding-protein-dependent transport systems inner membrane component
359391008756	Polycystic kidney disease type 1 protein:Binding-protein-dependent transport systems inner membrane component
359391008757	nitrite extrusion protein
359391008758	sugar ABC transporter, periplasmic sugar-binding protein
359391008759	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
359391008760	Respiratory nitrate reductase alpha N-terminal; Region: Nitr_red_alph_N; pfam14710
359391008761	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
359391008762	[4Fe-4S] binding site [ion binding]; other site
359391008763	molybdopterin cofactor binding site [chemical binding]; other site
359391008764	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
359391008765	molybdopterin cofactor binding site; other site
359391008766	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
359391008767	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
359391008768	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
359391008769	Respiratory nitrate reductase beta C-terminal; Region: Nitr_red_bet_C; pfam14711
359391008770	Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180
359391008771	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
359391008772	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
359391008773	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
359391008774	Protein of unknown function (DUF2478); Region: DUF2478; pfam10649
359391008775	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
359391008776	Carboxylyase-related protein
359391008777	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
359391008778	Putative lipid carrier protein [Lipid metabolism]; Region: COG3154
359391008779	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
359391008780	putative protease; Provisional; Region: PRK15447
359391008781	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
359391008782	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
359391008783	Walker A/P-loop; other site
359391008784	ATP binding site [chemical binding]; other site
359391008785	Q-loop/lid; other site
359391008786	ABC transporter signature motif; other site
359391008787	Walker B; other site
359391008788	D-loop; other site
359391008789	H-loop/switch region; other site
359391008790	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
359391008791	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391008792	dimer interface [polypeptide binding]; other site
359391008793	conserved gate region; other site
359391008794	putative PBP binding loops; other site
359391008795	ABC-ATPase subunit interface; other site
359391008796	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
359391008797	NMT1-like family; Region: NMT1_2; cl17432
359391008798	Uncharacterized protein involved in response to NO [Inorganic ion transport and metabolism]; Region: NnrS; COG3213
359391008799	Pseudoazurin (Paz) is a type I blue copper electron-transfer protein; Region: Pseudoazurin; cd04218
359391008800	Type 1 (T1) Cu binding site [ion binding]; other site
359391008801	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
359391008802	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
359391008803	ligand binding site [chemical binding]; other site
359391008804	flexible hinge region; other site
359391008805	putative switch regulator; other site
359391008806	helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419
359391008807	non-specific DNA interactions [nucleotide binding]; other site
359391008808	DNA binding site [nucleotide binding]
359391008809	sequence specific DNA binding site [nucleotide binding]; other site
359391008810	putative cAMP binding site [chemical binding]; other site
359391008811	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
359391008812	Predicted lipoprotein involved in nitrous oxide reduction [Energy production and conversion]; Region: NosL; COG4314
359391008813	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
359391008814	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
359391008815	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
359391008816	Walker A/P-loop; other site
359391008817	ATP binding site [chemical binding]; other site
359391008818	Q-loop/lid; other site
359391008819	ABC transporter signature motif; other site
359391008820	Walker B; other site
359391008821	D-loop; other site
359391008822	H-loop/switch region; other site
359391008823	Nitrous oxidase accessory protein [Inorganic ion transport and metabolism]; Region: NosD; COG3420
359391008824	Domain present in carbohydrate binding proteins and sugar hydrolses; Region: CASH; smart00722
359391008825	Domain present in carbohydrate binding proteins and sugar hydrolses; Region: CASH; smart00722
359391008826	nitrous-oxide reductase; Validated; Region: PRK02888
359391008827	The C-terminal cupredoxin domain of Nitrous-oxide reductase; Region: N2OR_C; cd04223
359391008828	dimer interface [polypeptide binding]; other site
359391008829	CuA binuclear site [ion binding]; other site
359391008830	Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901
359391008831	ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163
359391008832	4Fe-4S binding domain; Region: Fer4_5; pfam12801
359391008833	4Fe-4S binding domain; Region: Fer4_5; pfam12801
359391008834	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
359391008835	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
359391008836	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
359391008837	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
359391008838	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
359391008839	RES domain; Region: RES; smart00953
359391008840	Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069
359391008841	Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782
359391008842	N- and C-terminal domain interface [polypeptide binding]; other site
359391008843	active site
359391008844	MgATP binding site [chemical binding]; other site
359391008845	catalytic site [active]
359391008846	metal binding site [ion binding]; metal-binding site
359391008847	carbohydrate binding site [chemical binding]; other site
359391008848	putative homodimer interface [polypeptide binding]; other site
359391008849	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
359391008850	classical (c) SDRs; Region: SDR_c; cd05233
359391008851	NAD(P) binding site [chemical binding]; other site
359391008852	active site
359391008853	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
359391008854	TM-ABC transporter signature motif; other site
359391008855	ATP/GTP-binding site motif A (P-loop):ABC transporter:AAA ATPase
359391008856	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
359391008857	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
359391008858	putative ligand binding site [chemical binding]; other site
359391008859	Transcriptional regulators [Transcription]; Region: PurR; COG1609
359391008860	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
359391008861	DNA binding site [nucleotide binding]
359391008862	domain linker motif; other site
359391008863	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
359391008864	dimerization interface [polypeptide binding]; other site
359391008865	ligand binding site [chemical binding]; other site
359391008866	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
359391008867	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
359391008868	ligand binding site [chemical binding]; other site
359391008869	flexible hinge region; other site
359391008870	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
359391008871	putative switch regulator; other site
359391008872	non-specific DNA interactions [nucleotide binding]; other site
359391008873	DNA binding site [nucleotide binding]
359391008874	sequence specific DNA binding site [nucleotide binding]; other site
359391008875	putative cAMP binding site [chemical binding]; other site
359391008876	Uncharacterized conserved protein [Function unknown]; Region: COG1262
359391008877	Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; cl19582
359391008878	nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376
359391008879	Cupredoxin domain 1 of Copper-containing nitrite reductase; Region: CuRO_1_CuNIR; cd11020
359391008880	Type 1 (T1) Cu binding site [ion binding]; other site
359391008881	trimer interface [polypeptide binding]; other site
359391008882	Type II Cu binding site [ion binding]; other site
359391008883	Cupredoxin superfamily; Region: Cupredoxin; cl19115
359391008884	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
359391008885	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
359391008886	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
359391008887	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
359391008888	Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006
359391008889	Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006
359391008890	Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719
359391008891	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
359391008892	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
359391008893	metal ion-dependent adhesion site (MIDAS); other site
359391008894	MoxR-like ATPases [General function prediction only]; Region: COG0714
359391008895	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
359391008896	Walker A motif; other site
359391008897	ATP binding site [chemical binding]; other site
359391008898	Walker B motif; other site
359391008899	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
359391008900	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
359391008901	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
359391008902	Low-spin heme binding site [chemical binding]; other site
359391008903	D-pathway; other site
359391008904	K-pathway; other site
359391008905	Binuclear center (active site) [active]
359391008906	Putative proton exit pathway; other site
359391008907	Cytochrome c; Region: Cytochrom_C; pfam00034
359391008908	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211
359391008909	Subunit I/III interface [polypeptide binding]; other site
359391008910	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
359391008911	Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440
359391008912	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
359391008913	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
359391008914	inhibitor site; inhibition site
359391008915	active site
359391008916	dimer interface [polypeptide binding]; other site
359391008917	catalytic residue [active]
359391008918	Transcriptional regulators [Transcription]; Region: GntR; COG1802
359391008919	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
359391008920	DNA-binding site [nucleotide binding]; DNA binding site
359391008921	FCD domain; Region: FCD; pfam07729
359391008922	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
359391008923	EamA-like transporter family; Region: EamA; pfam00892
359391008924	EamA-like transporter family; Region: EamA; cl17759
359391008925	GAF/GGDEF domain protein
359391008926	GGDEF domain protein
359391008927	GGDEF:FAD-dependent pyridine nucleotide-disulphide oxidoreductase
359391008928	DNA polymerase III subunit epsilon; Validated; Region: PRK09182
359391008929	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
359391008930	active site
359391008931	catalytic site [active]
359391008932	substrate binding site [chemical binding]; other site
359391008933	glutamyl-tRNA(gln) amidotransferase subunit A
359391008934	glutamyl-tRNA(gln) amidotransferase subunit A
359391008935	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
359391008936	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
359391008937	Walker A/P-loop; other site
359391008938	ATP binding site [chemical binding]; other site
359391008939	Q-loop/lid; other site
359391008940	ABC transporter signature motif; other site
359391008941	Walker B; other site
359391008942	D-loop; other site
359391008943	H-loop/switch region; other site
359391008944	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
359391008945	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
359391008946	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
359391008947	Walker A/P-loop; other site
359391008948	ATP binding site [chemical binding]; other site
359391008949	Q-loop/lid; other site
359391008950	ABC transporter signature motif; other site
359391008951	Walker B; other site
359391008952	D-loop; other site
359391008953	H-loop/switch region; other site
359391008954	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
359391008955	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
359391008956	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391008957	dimer interface [polypeptide binding]; other site
359391008958	conserved gate region; other site
359391008959	putative PBP binding loops; other site
359391008960	ABC-ATPase subunit interface; other site
359391008961	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
359391008962	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391008963	dimer interface [polypeptide binding]; other site
359391008964	conserved gate region; other site
359391008965	putative PBP binding loops; other site
359391008966	ABC-ATPase subunit interface; other site
359391008967	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
359391008968	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494
359391008969	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345
359391008970	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
359391008971	putative NAD(P) binding site [chemical binding]; other site
359391008972	active site
359391008973	Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109
359391008974	NAD(P) binding site [chemical binding]; other site
359391008975	catalytic residues [active]
359391008976	catalytic residues [active]
359391008977	Transcriptional regulators [Transcription]; Region: GntR; COG1802
359391008978	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
359391008979	DNA-binding site [nucleotide binding]; DNA binding site
359391008980	FCD domain; Region: FCD; pfam07729
359391008981	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
359391008982	Major Facilitator Superfamily; Region: MFS_1; pfam07690
359391008983	putative substrate translocation pore; other site
359391008984	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
359391008986	possible translation initiation inhibitor
359391008987	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
359391008988	ribonuclease P; Reviewed; Region: rnpA; PRK01313
359391008989	membrane protein insertase; Provisional; Region: PRK01318
359391008990	YidC periplasmic domain; Region: YidC_periplas; pfam14849
359391008991	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
359391008992	Predicted GTPase [General function prediction only]; Region: COG0218
359391008993	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
359391008994	G1 box; other site
359391008995	GTP/Mg2+ binding site [chemical binding]; other site
359391008996	Switch I region; other site
359391008997	G2 box; other site
359391008998	G3 box; other site
359391008999	Switch II region; other site
359391009000	G4 box; other site
359391009001	G5 box; other site
359391009002	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
359391009003	homohexameric interface [polypeptide binding]; other site
359391009004	feedback inhibition sensing region; other site
359391009005	nucleotide binding site [chemical binding]; other site
359391009006	N-acetyl-L-glutamate binding site [chemical binding]; other site
359391009007	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
359391009008	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
359391009009	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
359391009010	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
359391009011	Tetrahydrodipicolinate N-succinyltransferase N-terminal; Region: THDPS_N_2; pfam14805
359391009012	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
359391009013	trimer interface [polypeptide binding]; other site
359391009014	active site
359391009015	substrate binding site [chemical binding]; other site
359391009016	CoA binding site [chemical binding]; other site
359391009017	conserved hypothetical protein
359391009018	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
359391009019	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
359391009020	metal binding site [ion binding]; metal-binding site
359391009021	dimer interface [polypeptide binding]; other site
359391009022	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
359391009023	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
359391009024	dimerization interface 3.5A [polypeptide binding]; other site
359391009025	active site
359391009026	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
359391009027	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
359391009028	putative active site [active]
359391009029	substrate binding site [chemical binding]; other site
359391009030	putative cosubstrate binding site; other site
359391009031	catalytic site [active]
359391009032	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
359391009033	substrate binding site [chemical binding]; other site
359391009034	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
359391009035	active site
359391009036	catalytic residues [active]
359391009037	metal binding site [ion binding]; metal-binding site
359391009038	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
359391009039	RmuC family; Region: RmuC; pfam02646
359391009040	Uncharacterized protein conserved in bacteria [Posttranslational modification, protein turnover, chaperones]; Region: COG3526
359391009041	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
359391009042	GIY-YIG motif/motif A; other site
359391009043	putative active site [active]
359391009044	putative metal binding site [ion binding]; other site
359391009045	GTP-binding protein LepA; Provisional; Region: PRK05433
359391009046	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
359391009047	G1 box; other site
359391009048	putative GEF interaction site [polypeptide binding]; other site
359391009049	GTP/Mg2+ binding site [chemical binding]; other site
359391009050	Switch I region; other site
359391009051	G2 box; other site
359391009052	G3 box; other site
359391009053	Switch II region; other site
359391009054	G4 box; other site
359391009055	G5 box; other site
359391009056	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
359391009057	Elongation Factor G, domain II; Region: EFG_II; pfam14492
359391009058	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
359391009059	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
359391009060	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
359391009061	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
359391009062	putative NAD(P) binding site [chemical binding]; other site
359391009063	active site
359391009064	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
359391009065	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
359391009066	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
359391009067	C-terminal domain interface [polypeptide binding]; other site
359391009068	GSH binding site (G-site) [chemical binding]; other site
359391009069	dimer interface [polypeptide binding]; other site
359391009070	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
359391009071	N-terminal domain interface [polypeptide binding]; other site
359391009072	dimer interface [polypeptide binding]; other site
359391009073	substrate binding pocket (H-site) [chemical binding]; other site
359391009074	epoxyqueuosine reductase; Region: TIGR00276
359391009075	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
359391009076	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
359391009077	HEAT repeat; Region: HEAT; pfam02985
359391009078	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
359391009079	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
359391009080	putative NAD(P) binding site [chemical binding]; other site
359391009081	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
359391009082	Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770
359391009083	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
359391009084	active site
359391009085	dimer interfaces [polypeptide binding]; other site
359391009086	catalytic residues [active]
359391009087	Glucokinase [Carbohydrate transport and metabolism]; Region: Glk; COG0837
359391009088	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
359391009089	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
359391009090	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
359391009091	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
359391009092	Walker A/P-loop; other site
359391009093	ATP binding site [chemical binding]; other site
359391009094	Q-loop/lid; other site
359391009095	ABC transporter signature motif; other site
359391009096	Walker B; other site
359391009097	D-loop; other site
359391009098	H-loop/switch region; other site
359391009099	Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289
359391009100	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
359391009101	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
359391009102	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
359391009103	catalytic core [active]
359391009104	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
359391009105	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
359391009106	active site
359391009107	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
359391009108	putative FMN binding site [chemical binding]; other site
359391009109	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
359391009110	Ligand Binding Site [chemical binding]; other site
359391009111	Predicted membrane protein [Function unknown]; Region: COG3714
359391009112	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
359391009113	NAD(P) binding site [chemical binding]; other site
359391009114	catalytic residues [active]
359391009115	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
359391009116	putative catalytic site [active]
359391009117	putative metal binding site [ion binding]; other site
359391009118	putative phosphate binding site [ion binding]; other site
359391009119	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
359391009120	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
359391009121	Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157
359391009122	putative active site [active]
359391009123	catalytic site [active]
359391009124	Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163
359391009125	putative active site [active]
359391009126	catalytic site [active]
359391009127	conserved hypothetical protein
359391009128	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
359391009129	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
359391009130	G1 box; other site
359391009131	putative GEF interaction site [polypeptide binding]; other site
359391009132	GTP/Mg2+ binding site [chemical binding]; other site
359391009133	Switch I region; other site
359391009134	G2 box; other site
359391009135	G3 box; other site
359391009136	Switch II region; other site
359391009137	G4 box; other site
359391009138	G5 box; other site
359391009139	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
359391009140	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
359391009141	Flavoprotein; Region: Flavoprotein; cl19190
359391009142	DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127
359391009143	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
359391009144	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
359391009145	active site
359391009146	ATP binding site [chemical binding]; other site
359391009147	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
359391009148	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
359391009149	S-adenosylmethionine binding site [chemical binding]; other site
359391009150	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
359391009151	active site
359391009152	hypothetical protein; Provisional; Region: PRK00736
359391009153	methionine sulfoxide reductase A; Provisional; Region: PRK00058
359391009154	putative transposase OrfB; Reviewed; Region: PHA02517
359391009155	HTH-like domain; Region: HTH_21; pfam13276
359391009156	Integrase core domain; Region: rve; pfam00665
359391009157	Integrase core domain; Region: rve_3; pfam13683
359391009158	Transcriptional regulators [Transcription]; Region: GntR; COG1802
359391009159	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
359391009160	DNA-binding site [nucleotide binding]; DNA binding site
359391009161	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
359391009162	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
359391009163	tetramerization interface [polypeptide binding]; other site
359391009164	NAD(P) binding site [chemical binding]; other site
359391009165	catalytic residues [active]
359391009166	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
359391009167	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
359391009168	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
359391009169	Walker A/P-loop; other site
359391009170	ATP binding site [chemical binding]; other site
359391009171	Q-loop/lid; other site
359391009172	ABC transporter signature motif; other site
359391009173	Walker B; other site
359391009174	D-loop; other site
359391009175	H-loop/switch region; other site
359391009176	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
359391009177	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
359391009178	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
359391009179	Walker A/P-loop; other site
359391009180	ATP binding site [chemical binding]; other site
359391009181	Q-loop/lid; other site
359391009182	ABC transporter signature motif; other site
359391009183	Walker B; other site
359391009184	D-loop; other site
359391009185	H-loop/switch region; other site
359391009186	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
359391009187	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
359391009188	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
359391009189	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
359391009190	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391009191	dimer interface [polypeptide binding]; other site
359391009192	conserved gate region; other site
359391009193	putative PBP binding loops; other site
359391009194	ABC-ATPase subunit interface; other site
359391009195	Transcriptional regulator [Transcription]; Region: IclR; COG1414
359391009196	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
359391009197	Bacterial transcriptional regulator; Region: IclR; pfam01614
359391009198	acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875
359391009199	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
359391009200	E3 interaction surface; other site
359391009201	lipoyl attachment site [posttranslational modification]; other site
359391009202	e3 binding domain; Region: E3_binding; pfam02817
359391009203	Putative lysophospholipase; Region: Hydrolase_4; cl19140
359391009204	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
359391009205	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
359391009206	Dehydrogenase, E1 component:Transketolase, central region:Transketolase, C terminal
359391009207	3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268
359391009208	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
359391009209	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
359391009210	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
359391009211	enoyl-CoA hydratase; Provisional; Region: PRK08138
359391009212	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
359391009213	substrate binding site [chemical binding]; other site
359391009214	oxyanion hole (OAH) forming residues; other site
359391009215	trimer interface [polypeptide binding]; other site
359391009216	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
359391009217	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
359391009218	active site
359391009219	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
359391009220	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
359391009221	active site
359391009222	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
359391009223	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502
359391009224	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
359391009225	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391009226	dimer interface [polypeptide binding]; other site
359391009227	conserved gate region; other site
359391009228	putative PBP binding loops; other site
359391009229	ABC-ATPase subunit interface; other site
359391009230	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
359391009231	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391009232	dimer interface [polypeptide binding]; other site
359391009233	conserved gate region; other site
359391009234	putative PBP binding loops; other site
359391009235	ABC-ATPase subunit interface; other site
359391009236	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
359391009237	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
359391009238	Walker A/P-loop; other site
359391009239	ATP binding site [chemical binding]; other site
359391009240	Q-loop/lid; other site
359391009241	ABC transporter signature motif; other site
359391009242	Walker B; other site
359391009243	D-loop; other site
359391009244	H-loop/switch region; other site
359391009245	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
359391009246	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
359391009247	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
359391009248	Walker A/P-loop; other site
359391009249	ATP binding site [chemical binding]; other site
359391009250	Q-loop/lid; other site
359391009251	ABC transporter signature motif; other site
359391009252	Walker B; other site
359391009253	D-loop; other site
359391009254	H-loop/switch region; other site
359391009255	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
359391009256	Transcriptional regulators [Transcription]; Region: GntR; COG1802
359391009257	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
359391009258	DNA-binding site [nucleotide binding]; DNA binding site
359391009259	FCD domain; Region: FCD; pfam07729
359391009260	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
359391009261	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
359391009262	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
359391009263	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391009264	dimer interface [polypeptide binding]; other site
359391009265	conserved gate region; other site
359391009266	putative PBP binding loops; other site
359391009267	ABC-ATPase subunit interface; other site
359391009268	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
359391009269	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391009270	dimer interface [polypeptide binding]; other site
359391009271	conserved gate region; other site
359391009272	putative PBP binding loops; other site
359391009273	ABC-ATPase subunit interface; other site
359391009274	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
359391009275	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
359391009276	Walker A/P-loop; other site
359391009277	ATP binding site [chemical binding]; other site
359391009278	Q-loop/lid; other site
359391009279	ABC transporter signature motif; other site
359391009280	Walker B; other site
359391009281	D-loop; other site
359391009282	H-loop/switch region; other site
359391009283	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
359391009284	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
359391009285	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
359391009286	Walker A/P-loop; other site
359391009287	ATP binding site [chemical binding]; other site
359391009288	Q-loop/lid; other site
359391009289	ABC transporter signature motif; other site
359391009290	Walker B; other site
359391009291	D-loop; other site
359391009292	H-loop/switch region; other site
359391009293	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
359391009294	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
359391009295	amidase; Provisional; Region: PRK07486
359391009296	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
359391009297	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
359391009298	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391009299	dimer interface [polypeptide binding]; other site
359391009300	conserved gate region; other site
359391009301	putative PBP binding loops; other site
359391009302	ABC-ATPase subunit interface; other site
359391009303	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391009304	dimer interface [polypeptide binding]; other site
359391009305	conserved gate region; other site
359391009306	putative PBP binding loops; other site
359391009307	ABC-ATPase subunit interface; other site
359391009308	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
359391009309	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
359391009310	Walker A/P-loop; other site
359391009311	ATP binding site [chemical binding]; other site
359391009312	Q-loop/lid; other site
359391009313	ABC transporter signature motif; other site
359391009314	Walker B; other site
359391009315	D-loop; other site
359391009316	H-loop/switch region; other site
359391009317	TOBE domain; Region: TOBE_2; pfam08402
359391009318	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
359391009319	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
359391009320	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
359391009321	catalytic residue [active]
359391009322	Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235
359391009323	intersubunit interface [polypeptide binding]; other site
359391009324	active site
359391009325	Zn2+ binding site [ion binding]; other site
359391009326	conserved hypothetical protein
359391009327	conserved hypothetical protein
359391009328	conserved hypothetical protein
359391009329	Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337
359391009330	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
359391009331	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
359391009332	Transposase; Region: HTH_Tnp_1; cl17663
359391009333	putative transposase OrfB; Reviewed; Region: PHA02517
359391009334	HTH-like domain; Region: HTH_21; pfam13276
359391009335	Integrase core domain; Region: rve; pfam00665
359391009336	Integrase core domain; Region: rve_3; pfam13683
359391009337	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
359391009338	nucleotide binding site [chemical binding]; other site
359391009339	Predicted transcriptional regulator [Transcription]; Region: COG1959
359391009340	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
359391009341	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
359391009342	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
359391009343	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
359391009344	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
359391009345	metal binding site [ion binding]; metal-binding site
359391009346	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
359391009347	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
359391009348	Walker A/P-loop; other site
359391009349	ATP binding site [chemical binding]; other site
359391009350	Q-loop/lid; other site
359391009351	ABC transporter signature motif; other site
359391009352	Walker B; other site
359391009353	D-loop; other site
359391009354	H-loop/switch region; other site
359391009355	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
359391009356	ABC-ATPase subunit  interface; other site
359391009357	dimer interface [polypeptide binding]; other site
359391009358	putative PBP binding regions; other site
359391009359	Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735
359391009360	metal binding site 2 [ion binding]; metal-binding site
359391009361	putative DNA binding helix; other site
359391009362	metal binding site 1 [ion binding]; metal-binding site
359391009363	dimer interface [polypeptide binding]; other site
359391009364	structural Zn2+ binding site [ion binding]; other site
359391009365	PilZ domain; Region: PilZ; pfam07238
359391009366	FlgN protein; Region: FlgN; pfam05130
359391009367	Rod binding protein; Region: Rod-binding; pfam10135
359391009368	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
359391009369	flagellar biosynthetic protein FlhA KO: K02400 flagellar biosynthesis protein FlhA
359391009370	Bacterial type III secretion FHIPEP
359391009371	flagellar biosynthetic protein FlhA KO: K02400 flagellar biosynthesis protein FlhA
359391009372	flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010
359391009373	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009
359391009374	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
359391009375	Flagellar biosynthesis regulator FlbT [Cell motility and secretion]; Region: FlbT; COG5443
359391009376	flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793
359391009377	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008
359391009378	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
359391009379	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
359391009380	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521
359391009381	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
359391009382	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
359391009383	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
359391009384	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
359391009385	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
359391009386	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
359391009387	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
359391009388	active site
359391009389	dimerization interface [polypeptide binding]; other site
359391009390	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
359391009391	DNA binding site [nucleotide binding]
359391009392	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
359391009393	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
359391009394	N-acetyl-D-glucosamine binding site [chemical binding]; other site
359391009395	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
359391009396	chemotaxis protein; Reviewed; Region: PRK12798
359391009397	flagellar motor protein MotB; Validated; Region: motB; PRK05996
359391009398	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
359391009399	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
359391009400	ligand binding site [chemical binding]; other site
359391009401	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
359391009402	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
359391009403	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
359391009404	flagellin; Reviewed; Region: PRK12687
359391009405	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
359391009406	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
359391009407	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
359391009408	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
359391009409	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
359391009410	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
359391009411	autotransporter-associated beta strand repeat; Region: autotrns_rpt; TIGR02601
359391009412	autotransporter-associated beta strand repeat; Region: autotrns_rpt; TIGR02601
359391009413	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
359391009414	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
359391009415	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
359391009416	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
359391009417	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
359391009418	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
359391009419	Autotransporter beta-domain; Region: Autotransporter; smart00869
359391009420	Uncharacterized conserved protein [Function unknown]; Region: COG3268
359391009421	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
359391009422	NAD(P) binding site [chemical binding]; other site
359391009423	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
359391009424	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
359391009425	putative ligand binding site [chemical binding]; other site
359391009426	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
359391009427	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
359391009428	Walker A/P-loop; other site
359391009429	ATP binding site [chemical binding]; other site
359391009430	Q-loop/lid; other site
359391009431	ABC transporter signature motif; other site
359391009432	Walker B; other site
359391009433	D-loop; other site
359391009434	H-loop/switch region; other site
359391009435	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
359391009436	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
359391009437	TM-ABC transporter signature motif; other site
359391009438	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
359391009439	AraC-binding-like domain; Region: AraC_binding_2; pfam14525
359391009440	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
359391009441	Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106
359391009442	NAD(P) binding site [chemical binding]; other site
359391009443	catalytic residues [active]
359391009444	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Region: HpaI; TIGR02311
359391009445	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
359391009446	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
359391009447	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
359391009448	3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295
359391009449	N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266
359391009450	tetramer interface [polypeptide binding]; other site
359391009451	C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256
359391009452	tetramer interface [polypeptide binding]; other site
359391009453	active site
359391009454	metal binding site [ion binding]; metal-binding site
359391009455	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
359391009456	NAD binding site [chemical binding]; other site
359391009457	catalytic residues [active]
359391009458	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
359391009459	putative substrate binding pocket [chemical binding]; other site
359391009460	trimer interface [polypeptide binding]; other site
359391009461	MarR family; Region: MarR_2; cl17246
359391009462	Transcriptional regulators [Transcription]; Region: MarR; COG1846
359391009463	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
359391009464	Phosphotransferase enzyme family; Region: APH; pfam01636
359391009465	active site
359391009466	ATP binding site [chemical binding]; other site
359391009467	substrate binding site [chemical binding]; other site
359391009468	aminotransferase, class III
359391009469	ATP/GTP-binding site motif A (P-loop):Aminotransferase class-III
359391009470	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
359391009471	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
359391009472	inhibitor-cofactor binding pocket; inhibition site
359391009473	pyridoxal 5'-phosphate binding site [chemical binding]; other site
359391009474	catalytic residue [active]
359391009475	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
359391009476	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
359391009477	motif II; other site
359391009478	Uncharacterized protein family (UPF0261); Region: UPF0261; cl02262
359391009479	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
359391009480	Transcriptional regulator [Transcription]; Region: IclR; COG1414
359391009481	Bacterial transcriptional regulator; Region: IclR; pfam01614
359391009482	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
359391009483	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
359391009484	NAD(P) binding site [chemical binding]; other site
359391009485	catalytic residues [active]
359391009486	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
359391009487	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
359391009488	active site
359391009489	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
359391009490	putative ligand binding site [chemical binding]; other site
359391009491	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
359391009492	TM-ABC transporter signature motif; other site
359391009493	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
359391009494	TM-ABC transporter signature motif; other site
359391009495	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
359391009496	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
359391009497	Walker A/P-loop; other site
359391009498	ATP binding site [chemical binding]; other site
359391009499	Q-loop/lid; other site
359391009500	ABC transporter signature motif; other site
359391009501	Walker B; other site
359391009502	D-loop; other site
359391009503	H-loop/switch region; other site
359391009504	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
359391009505	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
359391009506	Walker A/P-loop; other site
359391009507	ATP binding site [chemical binding]; other site
359391009508	Q-loop/lid; other site
359391009509	ABC transporter signature motif; other site
359391009510	Walker B; other site
359391009511	D-loop; other site
359391009512	H-loop/switch region; other site
359391009513	Protein of unknown function (DUF1634); Region: DUF1634; pfam07843
359391009514	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
359391009515	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
359391009516	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
359391009517	DNA-binding site [nucleotide binding]; DNA binding site
359391009518	UTRA domain; Region: UTRA; pfam07702
359391009519	Bacterial extracellular solute-binding protein, family 1
359391009520	sugar ABC transporter, permease protein, putative KO: K02026 multiple sugar/glycerol-3P transport system permease...
359391009521	possible sugar ABC transporter, permease protein, putative KO: K02026 multiple sugar/glycerol-3P transport system permease...
359391009522	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391009523	dimer interface [polypeptide binding]; other site
359391009524	conserved gate region; other site
359391009525	putative PBP binding loops; other site
359391009526	ABC-ATPase subunit interface; other site
359391009527	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
359391009528	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
359391009529	Walker A/P-loop; other site
359391009530	ATP binding site [chemical binding]; other site
359391009531	Q-loop/lid; other site
359391009532	ABC transporter signature motif; other site
359391009533	Walker B; other site
359391009534	D-loop; other site
359391009535	H-loop/switch region; other site
359391009536	TOBE domain; Region: TOBE_2; pfam08402
359391009537	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
359391009538	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
359391009539	active site
359391009540	metal binding site [ion binding]; metal-binding site
359391009541	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
359391009542	Sulfatase; Region: Sulfatase; pfam00884
359391009543	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
359391009544	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
359391009545	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
359391009546	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
359391009547	Walker A/P-loop; other site
359391009548	ATP binding site [chemical binding]; other site
359391009549	Q-loop/lid; other site
359391009550	ABC transporter signature motif; other site
359391009551	Walker B; other site
359391009552	D-loop; other site
359391009553	H-loop/switch region; other site
359391009554	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
359391009555	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
359391009556	dimer interface [polypeptide binding]; other site
359391009557	conserved gate region; other site
359391009558	putative PBP binding loops; other site
359391009559	ABC-ATPase subunit interface; other site
359391009560	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
359391009561	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
359391009562	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
359391009563	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
359391009564	nucleotide binding site [chemical binding]; other site
359391009565	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
359391009566	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
359391009567	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
359391009568	N-terminal plug; other site
359391009569	ligand-binding site [chemical binding]; other site
359391009570	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
359391009571	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
359391009572	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
359391009573	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_5; cd06338
359391009574	Receptor family ligand binding region; Region: ANF_receptor; pfam01094
359391009575	putative ligand binding site [chemical binding]; other site
359391009576	Bacterial inner-membrane translocator
359391009577	Bacterial inner-membrane translocator
359391009578	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
359391009579	TM-ABC transporter signature motif; other site
359391009580	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
359391009581	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
359391009582	Walker A/P-loop; other site
359391009583	ATP binding site [chemical binding]; other site
359391009584	Q-loop/lid; other site
359391009585	ABC transporter signature motif; other site
359391009586	Walker B; other site
359391009587	D-loop; other site
359391009588	H-loop/switch region; other site
359391009589	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
359391009590	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
359391009591	Walker A/P-loop; other site
359391009592	ATP binding site [chemical binding]; other site
359391009593	Q-loop/lid; other site
359391009594	ABC transporter signature motif; other site
359391009595	Walker B; other site
359391009596	D-loop; other site
359391009597	H-loop/switch region; other site
359391009598	H+ transporting ATPase, proton pump:ATPase, E1-E2 type:Haloacid dehalogenase-like hydrolase
359391009599	Cadmium-transporting ATPase:Copper-transporting ATPase:ATPase, E1-E2 type
359391009600	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
359391009601	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
359391009602	FeS/SAM binding site; other site
359391009603	HemN C-terminal domain; Region: HemN_C; pfam06969
359391009604	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
359391009605	MerR family regulatory protein; Region: MerR; pfam00376
359391009606	DNA binding residues [nucleotide binding]
359391009607	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
359391009608	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
359391009609	P-loop; other site
359391009610	Magnesium ion binding site [ion binding]; other site
359391009611	plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454
359391009612	ParB-like nuclease domain; Region: ParBc; pfam02195
359391009613	RepB plasmid partitioning protein; Region: RepB; pfam07506