-- dump date 20140619_011035 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type NP_538919.1 17986285 1195727 192..1217 1 NC_003317.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 1217 hemE 1195727 hemE Brucella melitensis bv. 1 str. 16M uroporphyrinogen decarboxylase NP_538919.1 192 D 224914 CDS NP_538920.1 17986286 1195713 1286..1750 1 NC_003317.1 cytochrome functioning/assembly related protein 1750 1195713 BMEI0002 Brucella melitensis bv. 1 str. 16M cytochrome functioning/assembly related protein NP_538920.1 1286 D 224914 CDS NP_538921.1 17986287 1195714 2132..3397 1 NC_003317.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 3397 rho 1195714 rho Brucella melitensis bv. 1 str. 16M transcription termination factor Rho NP_538921.1 2132 D 224914 CDS NP_538922.1 17986288 1195715 complement(3482..3856) 1 NC_003317.1 hypothetical protein 3856 1195715 BMEI0004 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_538922.1 3482 R 224914 CDS NP_538923.1 17986289 1195716 complement(3984..5504) 1 NC_003317.1 thymidylate kinase 5504 1195716 BMEI0005 Brucella melitensis bv. 1 str. 16M thymidylate kinase NP_538923.1 3984 R 224914 CDS NP_538924.1 17986290 1195717 5526..6854 1 NC_003317.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 6854 trmE 1195717 trmE Brucella melitensis bv. 1 str. 16M tRNA modification GTPase TrmE NP_538924.1 5526 D 224914 CDS NP_538925.1 17986291 1195718 7015..8991 1 NC_003317.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification protein GidA 8991 1195718 BMEI0007 Brucella melitensis bv. 1 str. 16M tRNA uridine 5-carboxymethylaminomethyl modification protein GidA NP_538925.1 7015 D 224914 CDS NP_538926.1 17986292 1195719 8988..9629 1 NC_003317.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 9629 gidB 1195719 gidB Brucella melitensis bv. 1 str. 16M 16S rRNA methyltransferase GidB NP_538926.1 8988 D 224914 CDS NP_538927.1 17986293 1195720 9643..10479 1 NC_003317.1 chromosome partitioning protein PARA 10479 1195720 BMEI0009 Brucella melitensis bv. 1 str. 16M chromosome partitioning protein PARA NP_538927.1 9643 D 224914 CDS NP_538928.1 17986294 1195721 10523..11404 1 NC_003317.1 chromosome partitioning protein PARB 11404 1195721 BMEI0010 Brucella melitensis bv. 1 str. 16M chromosome partitioning protein PARB NP_538928.1 10523 D 224914 CDS NP_538929.1 17986295 1195722 complement(11498..12541) 1 NC_003317.1 required for the assembly and function of the DNAX complex which are required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta 12541 holA 1195722 holA Brucella melitensis bv. 1 str. 16M DNA polymerase III subunit delta NP_538929.1 11498 R 224914 CDS NP_538930.1 17986296 1195723 complement(12703..13497) 1 NC_003317.1 ABC transporter ATP-binding protein 13497 1195723 BMEI0012 Brucella melitensis bv. 1 str. 16M ABC transporter ATP-binding protein NP_538930.1 12703 R 224914 CDS NP_538931.1 17986297 1195724 complement(13494..14378) 1 NC_003317.1 ABC transporter membrane protein 14378 1195724 BMEI0013 Brucella melitensis bv. 1 str. 16M ABC transporter membrane protein NP_538931.1 13494 R 224914 CDS NP_538932.1 17986298 1195725 14633..14818 1 NC_003317.1 hypothetical protein 14818 1195725 BMEI0014 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_538932.1 14633 D 224914 CDS NP_538933.1 17986299 1195726 complement(15022..15966) 1 NC_003317.1 ABC transporter substrate-binding protein 15966 1195726 BMEI0015 Brucella melitensis bv. 1 str. 16M ABC transporter substrate-binding protein NP_538933.1 15022 R 224914 CDS NP_538934.1 17986300 1195728 16050..16259 1 NC_003317.1 hypothetical protein 16259 1195728 BMEI0016 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_538934.1 16050 D 224914 CDS NP_538935.1 17986301 1195729 16256..17278 1 NC_003317.1 alkanal monooxygenase subunit alpha 17278 1195729 BMEI0017 Brucella melitensis bv. 1 str. 16M alkanal monooxygenase subunit alpha NP_538935.1 16256 D 224914 CDS NP_538936.1 17986302 1195730 complement(17312..18481) 1 NC_003317.1 hypothetical protein 18481 1195730 BMEI0018 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_538936.1 17312 R 224914 CDS NP_538937.1 17986303 1195731 18672..19790 1 NC_003317.1 LACI-family transcription regulator 19790 1195731 BMEI0019 Brucella melitensis bv. 1 str. 16M LACI-family transcription regulator NP_538937.1 18672 D 224914 CDS NP_538938.1 17986304 1195732 19769..20770 1 NC_003317.1 glucose-fructose oxidoreductase precursor 20770 1195732 BMEI0020 Brucella melitensis bv. 1 str. 16M glucose-fructose oxidoreductase precursor NP_538938.1 19769 D 224914 CDS NP_538939.1 17986305 1195733 20776..22266 1 NC_003317.1 acetoacetyl-COA transferase subunit alpha 22266 1195733 BMEI0021 Brucella melitensis bv. 1 str. 16M acetoacetyl-COA transferase subunit alpha NP_538939.1 20776 D 224914 CDS NP_538940.1 17986306 1195734 22268..22639 1 NC_003317.1 3-hydroxybutyryl-CoA dehydratase 22639 1195734 BMEI0022 Brucella melitensis bv. 1 str. 16M 3-hydroxybutyryl-CoA dehydratase NP_538940.1 22268 D 224914 CDS NP_538941.1 17986307 1195735 22584..23045 1 NC_003317.1 3-hydroxybutyryl-CoA dehydratase 23045 1195735 BMEI0023 Brucella melitensis bv. 1 str. 16M 3-hydroxybutyryl-CoA dehydratase NP_538941.1 22584 D 224914 CDS NP_538942.1 17986308 1195736 23039..24559 1 NC_003317.1 L-sorbosone dehydrogenase, NAD(P) dependent 24559 1195736 BMEI0024 Brucella melitensis bv. 1 str. 16M L-sorbosone dehydrogenase, NAD(P) dependent NP_538942.1 23039 D 224914 CDS NP_538943.1 17986309 1195737 24572..26056 1 NC_003317.1 L-sorbose dehydrogenase (FAD) 26056 1195737 BMEI0025 Brucella melitensis bv. 1 str. 16M L-sorbose dehydrogenase (FAD) NP_538943.1 24572 D 224914 CDS NP_538944.2 161511167 1195738 26053..26817 1 NC_003317.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 26817 fabG 1195738 fabG Brucella melitensis bv. 1 str. 16M 3-ketoacyl-ACP reductase NP_538944.2 26053 D 224914 CDS NP_538945.1 17986311 1195739 26783..27148 1 NC_003317.1 L-sorbose dehydrogenase 27148 1195739 BMEI0027 Brucella melitensis bv. 1 str. 16M L-sorbose dehydrogenase NP_538945.1 26783 D 224914 CDS NP_538946.1 17986312 1195740 27042..28109 1 NC_003317.1 L-sorbose dehydrogenase 28109 1195740 BMEI0028 Brucella melitensis bv. 1 str. 16M L-sorbose dehydrogenase NP_538946.1 27042 D 224914 CDS NP_538947.1 17986313 1195741 28116..28463 1 NC_003317.1 L-sorbose dehydrogenase 28463 1195741 BMEI0029 Brucella melitensis bv. 1 str. 16M L-sorbose dehydrogenase NP_538947.1 28116 D 224914 CDS NP_538948.1 17986314 1195742 complement(28520..28864) 1 NC_003317.1 hypothetical protein 28864 1195742 BMEI0030 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_538948.1 28520 R 224914 CDS NP_538949.1 17986315 1195743 complement(29014..29331) 1 NC_003317.1 hypothetical protein 29331 1195743 BMEI0031 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_538949.1 29014 R 224914 CDS NP_538950.1 17986316 1195744 29555..30319 1 NC_003317.1 3-oxoacyl-ACP reductase 30319 1195744 BMEI0032 Brucella melitensis bv. 1 str. 16M 3-oxoacyl-ACP reductase NP_538950.1 29555 D 224914 CDS NP_538951.1 17986317 1195745 complement(30518..31351) 1 NC_003317.1 N-acyl-L-amino acid amidohydrolase 31351 1195745 BMEI0033 Brucella melitensis bv. 1 str. 16M N-acyl-L-amino acid amidohydrolase NP_538951.1 30518 R 224914 CDS NP_538952.1 17986318 1195746 complement(31406..31681) 1 NC_003317.1 N-acyl-L-amino acid amidohydrolase 31681 1195746 BMEI0034 Brucella melitensis bv. 1 str. 16M N-acyl-L-amino acid amidohydrolase NP_538952.1 31406 R 224914 CDS NP_538953.1 17986319 1195747 31979..33091 1 NC_003317.1 D-alanyl-D-alanine carboxypeptidase 33091 1195747 BMEI0035 Brucella melitensis bv. 1 str. 16M D-alanyl-D-alanine carboxypeptidase NP_538953.1 31979 D 224914 CDS NP_538954.1 17986320 1195748 33093..34259 1 NC_003317.1 COBW protein 34259 1195748 BMEI0036 Brucella melitensis bv. 1 str. 16M COBW protein NP_538954.1 33093 D 224914 CDS NP_538955.1 17986321 1195749 complement(34277..34534) 1 NC_003317.1 transcriptional regulator 34534 1195749 BMEI0037 Brucella melitensis bv. 1 str. 16M transcriptional regulator NP_538955.1 34277 R 224914 CDS NP_538956.1 17986322 1195750 complement(34513..35724) 1 NC_003317.1 hypothetical protein 35724 1195750 BMEI0038 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_538956.1 34513 R 224914 CDS NP_538957.1 17986323 1195751 complement(35946..36899) 1 NC_003317.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; acetyl-CoA carboxylase carboxyltransferase subunit alpha 36899 1195751 BMEI0039 Brucella melitensis bv. 1 str. 16M acetyl-CoA carboxylase carboxyltransferase subunit alpha NP_538957.1 35946 R 224914 CDS NP_538958.1 17986324 1195752 complement(37038..37967) 1 NC_003317.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD 37967 xerD 1195752 xerD Brucella melitensis bv. 1 str. 16M site-specific tyrosine recombinase XerD NP_538958.1 37038 R 224914 CDS NP_538959.1 17986325 1195753 complement(37967..38149) 1 NC_003317.1 hypothetical protein 38149 1195753 BMEI0041 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_538959.1 37967 R 224914 CDS NP_538960.1 17986326 1195754 38388..38897 1 NC_003317.1 catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase 38897 1195754 BMEI0042 Brucella melitensis bv. 1 str. 16M shikimate kinase NP_538960.1 38388 D 224914 CDS NP_538961.1 17986327 1195755 38990..40126 1 NC_003317.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 40126 aroB 1195755 aroB Brucella melitensis bv. 1 str. 16M 3-dehydroquinate synthase NP_538961.1 38990 D 224914 CDS NP_538962.1 17986328 1195756 40190..41497 1 NC_003317.1 hypothetical protein 41497 1195756 BMEI0044 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_538962.1 40190 D 224914 CDS NP_538963.1 17986329 1195757 complement(41522..41830) 1 NC_003317.1 morphology/transcriptional regulatory protein BolA 41830 1195757 BMEI0045 Brucella melitensis bv. 1 str. 16M morphology/transcriptional regulatory protein BolA NP_538963.1 41522 R 224914 CDS NP_538964.1 17986330 1195758 41829..42026 1 NC_003317.1 hypothetical protein 42026 1195758 BMEI0046 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_538964.1 41829 D 224914 CDS NP_538965.1 17986331 1195759 42023..42652 1 NC_003317.1 DnaJ family molecular chaperone 42652 1195759 BMEI0047 Brucella melitensis bv. 1 str. 16M DnaJ family molecular chaperone NP_538965.1 42023 D 224914 CDS NP_538966.1 17986332 1195760 42646..42843 1 NC_003317.1 hypothetical protein 42843 1195760 BMEI0048 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_538966.1 42646 D 224914 CDS NP_538967.1 17986333 1195761 42897..43925 1 NC_003317.1 CobS protein 43925 1195761 BMEI0049 Brucella melitensis bv. 1 str. 16M CobS protein NP_538967.1 42897 D 224914 CDS NP_538968.1 17986334 1195762 44033..45934 1 NC_003317.1 CobT protein 45934 1195762 BMEI0050 Brucella melitensis bv. 1 str. 16M CobT protein NP_538968.1 44033 D 224914 CDS NP_538969.1 17986335 1195763 complement(46200..47192) 1 NC_003317.1 hypothetical protein 47192 1195763 BMEI0051 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_538969.1 46200 R 224914 CDS NP_538970.1 17986336 1195764 complement(47219..47968) 1 NC_003317.1 hypothetical protein 47968 1195764 BMEI0052 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_538970.1 47219 R 224914 CDS NP_538971.1 17986337 1195765 complement(48375..50816) 1 NC_003317.1 cation-transporting ATPase PACS 50816 1195765 BMEI0053 Brucella melitensis bv. 1 str. 16M cation-transporting ATPase PACS NP_538971.1 48375 R 224914 CDS NP_538972.1 17986338 1195766 50893..51315 1 NC_003317.1 mercuric resistance operon regulatory protein 51315 1195766 BMEI0054 Brucella melitensis bv. 1 str. 16M mercuric resistance operon regulatory protein NP_538972.1 50893 D 224914 CDS NP_538973.1 17986339 1195767 complement(51427..52149) 1 NC_003317.1 hypothetical protein 52149 1195767 BMEI0055 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_538973.1 51427 R 224914 CDS NP_538974.1 17986340 1195768 52604..52897 1 NC_003317.1 required for 70S ribosome assembly; 50S ribosomal protein L28 52897 rpmB 1195768 rpmB Brucella melitensis bv. 1 str. 16M 50S ribosomal protein L28 NP_538974.1 52604 D 224914 CDS NP_538975.1 17986341 1195769 52977..53648 1 NC_003317.1 hypothetical protein 53648 1195769 BMEI0057 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_538975.1 52977 D 224914 CDS NP_538976.1 17986342 1195770 complement(53789..57913) 1 NC_003317.1 serine protease 57913 1195770 BMEI0058 Brucella melitensis bv. 1 str. 16M serine protease NP_538976.1 53789 R 224914 CDS NP_538977.1 17986343 1195771 complement(58718..58966) 1 NC_003317.1 hypothetical protein 58966 1195771 BMEI0059 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_538977.1 58718 R 224914 CDS NP_538978.1 17986344 1195772 59103..60305 1 NC_003317.1 hypothetical protein 60305 1195772 BMEI0060 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_538978.1 59103 D 224914 CDS NP_538979.1 17986345 1195773 60314..60673 1 NC_003317.1 hypothetical protein 60673 1195773 BMEI0061 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_538979.1 60314 D 224914 CDS NP_538980.1 17986346 1195774 61107..62186 1 NC_003317.1 hypothetical protein 62186 1195774 BMEI0062 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_538980.1 61107 D 224914 CDS NP_538981.1 17986347 1195775 62656..63702 1 NC_003317.1 hypothetical protein 63702 1195775 BMEI0063 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_538981.1 62656 D 224914 CDS NP_538982.1 17986348 1195776 complement(63731..64030) 1 NC_003317.1 hypothetical protein 64030 1195776 BMEI0064 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_538982.1 63731 R 224914 CDS NP_538983.1 17986349 1195777 complement(64091..64636) 1 NC_003317.1 hypothetical protein 64636 1195777 BMEI0065 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_538983.1 64091 R 224914 CDS NP_538984.1 17986350 1195778 64844..65527 1 NC_003317.1 two component response regulator 65527 1195778 BMEI0066 Brucella melitensis bv. 1 str. 16M two component response regulator NP_538984.1 64844 D 224914 CDS NP_538985.1 17986351 1195779 65562..66023 1 NC_003317.1 cAMP-dependent protein kinase regulatory subunit 66023 1195779 BMEI0067 Brucella melitensis bv. 1 str. 16M cAMP-dependent protein kinase regulatory subunit NP_538985.1 65562 D 224914 CDS NP_538986.1 17986352 1195780 complement(66029..66898) 1 NC_003317.1 exodeoxyribonuclease III 66898 1195780 BMEI0068 Brucella melitensis bv. 1 str. 16M exodeoxyribonuclease III NP_538986.1 66029 R 224914 CDS NP_538987.1 17986353 1195781 complement(66938..67540) 1 NC_003317.1 outer membrane lipoproteins carrier protein precursor 67540 1195781 BMEI0069 Brucella melitensis bv. 1 str. 16M outer membrane lipoproteins carrier protein precursor NP_538987.1 66938 R 224914 CDS NP_538988.1 17986354 1195782 complement(68014..68700) 1 NC_003317.1 porin involved in osmoregulation allowing water to move into and out of the cell in response to osmotic pressure; aquaporin Z 68700 1195782 BMEI0070 Brucella melitensis bv. 1 str. 16M aquaporin Z NP_538988.1 68014 R 224914 CDS NP_538989.1 17986355 1195783 69178..69450 1 NC_003317.1 hypothetical protein 69450 1195783 BMEI0071 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_538989.1 69178 D 224914 CDS NP_538990.1 17986356 1195784 69759..70418 1 NC_003317.1 cell division ATP-binding protein FTSE 70418 1195784 BMEI0072 Brucella melitensis bv. 1 str. 16M cell division ATP-binding protein FTSE NP_538990.1 69759 D 224914 CDS NP_538991.1 17986357 1195785 70411..71412 1 NC_003317.1 cell division protein FTSX 71412 1195785 BMEI0073 Brucella melitensis bv. 1 str. 16M cell division protein FTSX NP_538991.1 70411 D 224914 CDS NP_538992.1 17986358 1195786 71559..72311 1 NC_003317.1 hypothetical protein 72311 1195786 BMEI0074 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_538992.1 71559 D 224914 CDS NP_538993.1 17986359 1195787 72370..73272 1 NC_003317.1 1-acyl-SN-glycerol-3-phosphate acyltransferase 73272 1195787 BMEI0075 Brucella melitensis bv. 1 str. 16M 1-acyl-SN-glycerol-3-phosphate acyltransferase NP_538993.1 72370 D 224914 CDS NP_538994.1 17986360 1195788 73425..73955 1 NC_003317.1 catalyzes the hydrolysis of pyrophosphate to phosphate; inorganic pyrophosphatase 73955 1195788 BMEI0076 Brucella melitensis bv. 1 str. 16M inorganic pyrophosphatase NP_538994.1 73425 D 224914 CDS NP_538995.1 17986361 1195789 complement(74749..75321) 1 NC_003317.1 cation transport protein CHAC 75321 1195789 BMEI0077 Brucella melitensis bv. 1 str. 16M cation transport protein CHAC NP_538995.1 74749 R 224914 CDS NP_538996.1 17986362 1195790 75521..76540 1 NC_003317.1 hypothetical protein 76540 1195790 BMEI0078 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_538996.1 75521 D 224914 CDS NP_538997.1 17986363 1195791 complement(76509..77474) 1 NC_003317.1 dual function enzyme catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate and the formation of tyrosine from arogenate; cyclohexadienyl dehydrogenase 77474 1195791 BMEI0079 Brucella melitensis bv. 1 str. 16M cyclohexadienyl dehydrogenase NP_538997.1 76509 R 224914 CDS NP_538998.1 17986364 1195792 complement(77479..78585) 1 NC_003317.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 78585 1195792 BMEI0080 Brucella melitensis bv. 1 str. 16M histidinol-phosphate aminotransferase NP_538998.1 77479 R 224914 CDS NP_538999.1 17986365 1195793 complement(78582..79508) 1 NC_003317.1 methyltransferase 79508 1195793 BMEI0081 Brucella melitensis bv. 1 str. 16M methyltransferase NP_538999.1 78582 R 224914 CDS NP_539000.1 17986366 1195794 79657..80193 1 NC_003317.1 Catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively; hypoxanthine-guanine phosphoribosyltransferase 80193 1195794 BMEI0082 Brucella melitensis bv. 1 str. 16M hypoxanthine-guanine phosphoribosyltransferase NP_539000.1 79657 D 224914 CDS NP_539001.1 17986367 1195795 complement(80233..82635) 1 NC_003317.1 hypothetical protein 82635 1195795 BMEI0083 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539001.1 80233 R 224914 CDS NP_539002.1 17986368 1195796 complement(82965..84230) 1 NC_003317.1 diaminopimelate decarboxylase 84230 1195796 BMEI0084 Brucella melitensis bv. 1 str. 16M diaminopimelate decarboxylase NP_539002.1 82965 R 224914 CDS NP_539003.1 17986369 1195797 complement(84258..84530) 1 NC_003317.1 hypothetical protein 84530 1195797 BMEI0085 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539003.1 84258 R 224914 CDS NP_539004.1 17986370 1195798 complement(84551..85951) 1 NC_003317.1 catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 85951 1195798 BMEI0086 Brucella melitensis bv. 1 str. 16M argininosuccinate lyase NP_539004.1 84551 R 224914 CDS NP_539005.1 17986371 1195799 86266..86721 1 NC_003317.1 thiol:disulfide interchange protein TlpA 86721 1195799 BMEI0087 Brucella melitensis bv. 1 str. 16M thiol:disulfide interchange protein TlpA NP_539005.1 86266 D 224914 CDS NP_539006.1 17986372 1195800 complement(86729..87214) 1 NC_003317.1 hypothetical protein 87214 1195800 BMEI0088 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539006.1 86729 R 224914 CDS NP_539007.1 17986373 1195801 complement(87232..88092) 1 NC_003317.1 ribonuclease BN 88092 1195801 BMEI0089 Brucella melitensis bv. 1 str. 16M ribonuclease BN NP_539007.1 87232 R 224914 CDS NP_539008.2 229220682 1195802 88250..89092 1 NC_003317.1 short chain dehydrogenase 89092 1195802 BMEI0090 Brucella melitensis bv. 1 str. 16M short chain dehydrogenase NP_539008.2 88250 D 224914 CDS NP_539009.1 17986375 1195803 89191..89325 1 NC_003317.1 hypothetical protein 89325 1195803 BMEI0091 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539009.1 89191 D 224914 CDS NP_539010.1 17986376 1195804 89285..89956 1 NC_003317.1 adenosylcobalamin-dependent diol dehydratase subunit gamma 89956 1195804 BMEI0092 Brucella melitensis bv. 1 str. 16M adenosylcobalamin-dependent diol dehydratase subunit gamma NP_539010.1 89285 D 224914 CDS NP_539011.1 17986377 1195805 complement(90052..90783) 1 NC_003317.1 radical SAM protein 90783 1195805 BMEI0093 Brucella melitensis bv. 1 str. 16M radical SAM protein NP_539011.1 90052 R 224914 CDS NP_539012.1 17986378 1195806 complement(90725..91171) 1 NC_003317.1 vacuolar ATP synthase 16 KD proteolipid subunit 91171 1195806 BMEI0094 Brucella melitensis bv. 1 str. 16M vacuolar ATP synthase 16 KD proteolipid subunit NP_539012.1 90725 R 224914 CDS NP_539013.1 17986379 1195807 complement(91171..91869) 1 NC_003317.1 succinoglycan biosynthesis regulator 91869 1195807 BMEI0095 Brucella melitensis bv. 1 str. 16M succinoglycan biosynthesis regulator NP_539013.1 91171 R 224914 CDS NP_539014.1 17986380 1195808 92205..92951 1 NC_003317.1 electron transfer flavoprotein subunit beta 92951 1195808 BMEI0096 Brucella melitensis bv. 1 str. 16M electron transfer flavoprotein subunit beta NP_539014.1 92205 D 224914 CDS NP_539015.1 17986381 1195809 92987..94033 1 NC_003317.1 electron transfer flavoprotein subunit alpha 94033 1195809 BMEI0097 Brucella melitensis bv. 1 str. 16M electron transfer flavoprotein subunit alpha NP_539015.1 92987 D 224914 CDS NP_539016.1 17986382 1195810 94144..94365 1 NC_003317.1 hypothetical protein 94365 1195810 BMEI0098 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539016.1 94144 D 224914 CDS NP_539017.1 17986383 1195811 94517..95392 1 NC_003317.1 converts (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA; 3-hydroxybutyryl-CoA dehydrogenase 95392 1195811 BMEI0099 Brucella melitensis bv. 1 str. 16M 3-hydroxybutyryl-CoA dehydrogenase NP_539017.1 94517 D 224914 CDS NP_539018.1 17986384 1195812 95552..95800 1 NC_003317.1 hypothetical protein 95800 1195812 BMEI0100 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539018.1 95552 D 224914 CDS NP_539019.1 17986385 1195813 complement(95882..96892) 1 NC_003317.1 cysteine synthase A 96892 1195813 BMEI0101 Brucella melitensis bv. 1 str. 16M cysteine synthase A NP_539019.1 95882 R 224914 CDS NP_539020.1 17986386 1195814 97112..97561 1 NC_003317.1 universal stress protein 97561 1195814 BMEI0102 Brucella melitensis bv. 1 str. 16M universal stress protein NP_539020.1 97112 D 224914 CDS NP_539021.1 17986387 1195815 97741..99024 1 NC_003317.1 catalyzes the formation of methanethiol and 2-ocobutanoate from L-methionine; methionine gamma-lyase 99024 1195815 BMEI0103 Brucella melitensis bv. 1 str. 16M methionine gamma-lyase NP_539021.1 97741 D 224914 CDS NP_539022.1 17986388 1195816 complement(99710..101077) 1 NC_003317.1 glucarate transporter 101077 1195816 BMEI0104 Brucella melitensis bv. 1 str. 16M glucarate transporter NP_539022.1 99710 R 224914 CDS NP_539023.1 17986389 1195817 101072..102040 1 NC_003317.1 L-asparaginase II 102040 1195817 BMEI0105 Brucella melitensis bv. 1 str. 16M L-asparaginase II NP_539023.1 101072 D 224914 CDS NP_539024.1 17986390 1195818 102110..102793 1 NC_003317.1 GntR family transcriptional regulator 102793 1195818 BMEI0106 Brucella melitensis bv. 1 str. 16M GntR family transcriptional regulator NP_539024.1 102110 D 224914 CDS NP_539025.1 17986391 1195819 complement(102930..103928) 1 NC_003317.1 L-asparaginase 103928 1195819 BMEI0107 Brucella melitensis bv. 1 str. 16M L-asparaginase NP_539025.1 102930 R 224914 CDS NP_539026.1 17986392 1195820 complement(103937..104692) 1 NC_003317.1 asparagine transport ATP-binding protein 104692 1195820 BMEI0108 Brucella melitensis bv. 1 str. 16M asparagine transport ATP-binding protein NP_539026.1 103937 R 224914 CDS NP_539027.1 17986393 1195821 complement(104676..106127) 1 NC_003317.1 catalyzes the formation of fumarate from aspartate; aspartate ammonia-lyase 106127 aspA 1195821 aspA Brucella melitensis bv. 1 str. 16M aspartate ammonia-lyase NP_539027.1 104676 R 224914 CDS NP_539028.1 17986394 1195822 complement(106136..107149) 1 NC_003317.1 agmatinase 107149 1195822 BMEI0110 Brucella melitensis bv. 1 str. 16M agmatinase NP_539028.1 106136 R 224914 CDS NP_539029.1 17986395 1195823 complement(107170..107985) 1 NC_003317.1 asparagine transport ATP-binding protein 107985 1195823 BMEI0111 Brucella melitensis bv. 1 str. 16M asparagine transport ATP-binding protein NP_539029.1 107170 R 224914 CDS NP_539030.1 17986396 1195824 complement(107982..108704) 1 NC_003317.1 asparagine transport system permease protein 108704 1195824 BMEI0112 Brucella melitensis bv. 1 str. 16M asparagine transport system permease protein NP_539030.1 107982 R 224914 CDS NP_539031.1 17986397 1195825 complement(108709..109443) 1 NC_003317.1 asparagine transport system permease protein 109443 1195825 BMEI0113 Brucella melitensis bv. 1 str. 16M asparagine transport system permease protein NP_539031.1 108709 R 224914 CDS NP_539032.1 17986398 1195826 complement(109493..109927) 1 NC_003317.1 asparagine-binding periplasmic protein precursor 109927 1195826 BMEI0114 Brucella melitensis bv. 1 str. 16M asparagine-binding periplasmic protein precursor NP_539032.1 109493 R 224914 CDS NP_539033.1 17986399 1195827 complement(110033..110266) 1 NC_003317.1 asparagine-binding periplasmic protein precursor 110266 1195827 BMEI0115 Brucella melitensis bv. 1 str. 16M asparagine-binding periplasmic protein precursor NP_539033.1 110033 R 224914 CDS NP_539034.1 17986400 1195828 110662..111588 1 NC_003317.1 LysR family transcriptional regulator 111588 1195828 BMEI0116 Brucella melitensis bv. 1 str. 16M LysR family transcriptional regulator NP_539034.1 110662 D 224914 CDS NP_539035.1 17986401 1195829 111736..111936 1 NC_003317.1 hypothetical protein 111936 1195829 BMEI0117 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539035.1 111736 D 224914 CDS NP_539036.1 17986402 1195830 complement(112771..114405) 1 NC_003317.1 hypothetical protein 114405 1195830 BMEI0118 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539036.1 112771 R 224914 CDS NP_539037.1 17986403 1195831 complement(114574..115566) 1 NC_003317.1 hypothetical protein 115566 1195831 BMEI0119 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539037.1 114574 R 224914 CDS NP_539038.1 17986404 1195832 115712..115903 1 NC_003317.1 hypothetical protein 115903 1195832 BMEI0120 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539038.1 115712 D 224914 CDS NP_539039.1 17986405 1195833 complement(116637..119357) 1 NC_003317.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 119357 secA 1195833 secA Brucella melitensis bv. 1 str. 16M preprotein translocase subunit SecA NP_539039.1 116637 R 224914 CDS NP_539040.1 17986406 1195834 119329..119568 1 NC_003317.1 hypothetical protein 119568 1195834 BMEI0122 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539040.1 119329 D 224914 CDS NP_539041.1 17986407 1195835 119696..120691 1 NC_003317.1 peptidyl-prolyl cis-trans isomerase 120691 1195835 BMEI0123 Brucella melitensis bv. 1 str. 16M peptidyl-prolyl cis-trans isomerase NP_539041.1 119696 D 224914 CDS NP_539042.1 17986408 1195836 121129..122370 1 NC_003317.1 bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate; bifunctional ornithine acetyltransferase/N-acetylglutamate synthase 122370 argJ 1195836 argJ Brucella melitensis bv. 1 str. 16M bifunctional ornithine acetyltransferase/N-acetylglutamate synthase NP_539042.1 121129 D 224914 CDS NP_539043.1 17986409 1195837 122461..123219 1 NC_003317.1 acetyltransferase 123219 1195837 BMEI0125 Brucella melitensis bv. 1 str. 16M acetyltransferase NP_539043.1 122461 D 224914 CDS NP_539044.1 17986410 1195838 123216..123632 1 NC_003317.1 mutator protein MutT 123632 1195838 BMEI0126 Brucella melitensis bv. 1 str. 16M mutator protein MutT NP_539044.1 123216 D 224914 CDS NP_539045.1 17986411 1195839 123825..124049 1 NC_003317.1 hypothetical protein 124049 1195839 BMEI0127 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539045.1 123825 D 224914 CDS NP_539046.1 17986412 1195840 complement(124114..124566) 1 NC_003317.1 hypothetical protein 124566 1195840 BMEI0128 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539046.1 124114 R 224914 CDS NP_539047.1 17986413 1195841 complement(124652..125425) 1 NC_003317.1 hydroxyacylglutathione hydrolase, mitochondrial 125425 1195841 BMEI0129 Brucella melitensis bv. 1 str. 16M hydroxyacylglutathione hydrolase, mitochondrial NP_539047.1 124652 R 224914 CDS NP_539048.2 161511166 1195842 complement(125458..126120) 1 NC_003317.1 Involved in cell division; probably involved in intracellular septation; intracellular septation protein A 126120 1195842 BMEI0130 Brucella melitensis bv. 1 str. 16M intracellular septation protein A NP_539048.2 125458 R 224914 CDS NP_539049.1 17986415 1195843 complement(126120..127064) 1 NC_003317.1 signal recognition particle receptor FTSY 127064 1195843 BMEI0131 Brucella melitensis bv. 1 str. 16M signal recognition particle receptor FTSY NP_539049.1 126120 R 224914 CDS NP_539050.1 17986416 1195844 complement(127539..128882) 1 NC_003317.1 Fe-S oxidoreductase 128882 1195844 BMEI0132 Brucella melitensis bv. 1 str. 16M Fe-S oxidoreductase NP_539050.1 127539 R 224914 CDS NP_539051.1 17986417 1195845 complement(128822..129733) 1 NC_003317.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase 129733 dapF 1195845 dapF Brucella melitensis bv. 1 str. 16M diaminopimelate epimerase NP_539051.1 128822 R 224914 CDS NP_539052.1 17986418 1195846 129764..129967 1 NC_003317.1 hypothetical protein 129967 1195846 BMEI0134 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539052.1 129764 D 224914 CDS NP_539053.1 17986419 1195847 130096..130629 1 NC_003317.1 outer membrane lipoprotein 130629 1195847 BMEI0135 Brucella melitensis bv. 1 str. 16M outer membrane lipoprotein NP_539053.1 130096 D 224914 CDS NP_539054.1 17986420 1195848 130701..131912 1 NC_003317.1 ATPase n2B 131912 1195848 BMEI0136 Brucella melitensis bv. 1 str. 16M ATPase n2B NP_539054.1 130701 D 224914 CDS NP_539055.2 161511165 1195849 132351..133313 1 NC_003317.1 Catalyzes the reversible oxidation of malate to oxaloacetate; malate dehydrogenase 133313 1195849 BMEI0137 Brucella melitensis bv. 1 str. 16M malate dehydrogenase NP_539055.2 132351 D 224914 CDS NP_539056.1 17986422 1195850 133420..134616 1 NC_003317.1 catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 134616 sucC 1195850 sucC Brucella melitensis bv. 1 str. 16M succinyl-CoA synthetase subunit beta NP_539056.1 133420 D 224914 CDS NP_539057.1 17986423 1195851 134620..135522 1 NC_003317.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha 135522 1195851 BMEI0139 Brucella melitensis bv. 1 str. 16M succinyl-CoA synthetase subunit alpha NP_539057.1 134620 D 224914 CDS NP_539058.1 17986424 1195852 135798..138812 1 NC_003317.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 138812 sucA 1195852 sucA Brucella melitensis bv. 1 str. 16M 2-oxoglutarate dehydrogenase E1 NP_539058.1 135798 D 224914 CDS NP_539059.1 17986425 1195853 138874..140100 1 NC_003317.1 component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA; dihydrolipoamide succinyltransferase 140100 1195853 BMEI0141 Brucella melitensis bv. 1 str. 16M dihydrolipoamide succinyltransferase NP_539059.1 138874 D 224914 CDS NP_539060.1 17986426 1195854 140110..140523 1 NC_003317.1 hypothetical protein 140523 1195854 BMEI0142 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539060.1 140110 D 224914 CDS NP_539061.1 17986427 1195855 140565..141203 1 NC_003317.1 threonine efflux protein 141203 1195855 BMEI0143 Brucella melitensis bv. 1 str. 16M threonine efflux protein NP_539061.1 140565 D 224914 CDS NP_539062.1 17986428 1195856 141274..141816 1 NC_003317.1 hypothetical protein 141816 1195856 BMEI0144 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539062.1 141274 D 224914 CDS NP_539063.1 17986429 1195857 141985..143388 1 NC_003317.1 Catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase 143388 1195857 BMEI0145 Brucella melitensis bv. 1 str. 16M dihydrolipoamide dehydrogenase NP_539063.1 141985 D 224914 CDS NP_539064.1 17986430 1195858 complement(143592..144452) 1 NC_003317.1 hypothetical protein 144452 1195858 BMEI0146 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539064.1 143592 R 224914 CDS NP_539065.1 17986431 1195859 complement(144647..145594) 1 NC_003317.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerC 145594 xerC 1195859 xerC Brucella melitensis bv. 1 str. 16M site-specific tyrosine recombinase XerC NP_539065.1 144647 R 224914 CDS NP_539066.1 17986432 1195860 145818..146387 1 NC_003317.1 Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 146387 rimM 1195860 rimM Brucella melitensis bv. 1 str. 16M 16S rRNA-processing protein RimM NP_539066.1 145818 D 224914 CDS NP_539067.1 17986433 1195861 146393..147118 1 NC_003317.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 147118 trmD 1195861 trmD Brucella melitensis bv. 1 str. 16M tRNA (guanine-N(1)-)-methyltransferase NP_539067.1 146393 D 224914 CDS NP_539068.1 17986434 1195862 complement(147253..147984) 1 NC_003317.1 ArsR family transcriptional regulator 147984 1195862 BMEI0150 Brucella melitensis bv. 1 str. 16M ArsR family transcriptional regulator NP_539068.1 147253 R 224914 CDS NP_539069.1 17986435 1195863 147989..148312 1 NC_003317.1 hypothetical protein 148312 1195863 BMEI0151 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539069.1 147989 D 224914 CDS NP_539070.1 17986436 1195864 148309..148671 1 NC_003317.1 hypothetical protein 148671 1195864 BMEI0152 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539070.1 148309 D 224914 CDS NP_539071.1 17986437 1195865 148640..149074 1 NC_003317.1 hypothetical protein 149074 1195865 BMEI0153 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539071.1 148640 D 224914 CDS NP_539072.1 17986438 1195866 149071..149307 1 NC_003317.1 hypothetical protein 149307 1195866 BMEI0154 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539072.1 149071 D 224914 CDS NP_539073.1 17986439 1195867 complement(149460..150689) 1 NC_003317.1 allantoin permease 150689 1195867 BMEI0155 Brucella melitensis bv. 1 str. 16M allantoin permease NP_539073.1 149460 R 224914 CDS NP_539074.1 17986440 1195868 151213..151650 1 NC_003317.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 151650 rplS 1195868 rplS Brucella melitensis bv. 1 str. 16M 50S ribosomal protein L19 NP_539074.1 151213 D 224914 CDS NP_539075.1 17986441 1195869 151861..153270 1 NC_003317.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit 153270 1195869 BMEI0157 Brucella melitensis bv. 1 str. 16M isopropylmalate isomerase large subunit NP_539075.1 151861 D 224914 CDS NP_539076.1 17986442 1195870 153527..153985 1 NC_003317.1 acetyltransferase 153985 1195870 BMEI0158 Brucella melitensis bv. 1 str. 16M acetyltransferase NP_539076.1 153527 D 224914 CDS NP_539077.1 17986443 1195871 154330..154728 1 NC_003317.1 succinate dehydrogenase cytochrome B-556 subunit 154728 1195871 BMEI0159 Brucella melitensis bv. 1 str. 16M succinate dehydrogenase cytochrome B-556 subunit NP_539077.1 154330 D 224914 CDS NP_539078.1 17986444 1195872 154751..155137 1 NC_003317.1 succinate dehydrogenase hydrophobic membrane anchor protein 155137 1195872 BMEI0160 Brucella melitensis bv. 1 str. 16M succinate dehydrogenase hydrophobic membrane anchor protein NP_539078.1 154751 D 224914 CDS NP_539079.1 17986445 1195873 155094..156986 1 NC_003317.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 156986 sdhA 1195873 sdhA Brucella melitensis bv. 1 str. 16M succinate dehydrogenase flavoprotein subunit NP_539079.1 155094 D 224914 CDS NP_539080.1 17986446 1195874 157002..157781 1 NC_003317.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit 157781 sdhB 1195874 sdhB Brucella melitensis bv. 1 str. 16M succinate dehydrogenase iron-sulfur subunit NP_539080.1 157002 D 224914 CDS NP_539081.1 17986447 1195875 complement(157750..158151) 1 NC_003317.1 hypothetical protein 158151 1195875 BMEI0163 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539081.1 157750 R 224914 CDS NP_539082.1 17986448 1195876 158117..158521 1 NC_003317.1 lactoylglutathione lyase 158521 1195876 BMEI0164 Brucella melitensis bv. 1 str. 16M lactoylglutathione lyase NP_539082.1 158117 D 224914 CDS NP_539083.1 17986449 1195877 complement(158607..159896) 1 NC_003317.1 2-octaprenyl-6-methoxyphenyl hydroxylase 159896 1195877 BMEI0165 Brucella melitensis bv. 1 str. 16M 2-octaprenyl-6-methoxyphenyl hydroxylase NP_539083.1 158607 R 224914 CDS NP_539084.1 17986450 1195878 160071..160973 1 NC_003317.1 acyl-CoA thioesterase 160973 1195878 BMEI0166 Brucella melitensis bv. 1 str. 16M acyl-CoA thioesterase NP_539084.1 160071 D 224914 CDS NP_539085.1 17986451 1195879 161196..162497 1 NC_003317.1 ammonium transporter 162497 1195879 BMEI0167 Brucella melitensis bv. 1 str. 16M ammonium transporter NP_539085.1 161196 D 224914 CDS NP_539086.1 17986452 1195880 162767..165160 1 NC_003317.1 DNA translocase FtsK 165160 1195880 BMEI0168 Brucella melitensis bv. 1 str. 16M DNA translocase FtsK NP_539086.1 162767 D 224914 CDS NP_539087.1 17986453 1195881 complement(165222..166676) 1 NC_003317.1 GntR family transcriptional regulator 166676 1195881 BMEI0169 Brucella melitensis bv. 1 str. 16M GntR family transcriptional regulator NP_539087.1 165222 R 224914 CDS NP_539088.1 17986454 1195882 166783..167688 1 NC_003317.1 transporter, DME family 167688 1195882 BMEI0170 Brucella melitensis bv. 1 str. 16M transporter, DME family NP_539088.1 166783 D 224914 CDS NP_539089.1 17986455 1195883 complement(167734..168390) 1 NC_003317.1 50S ribosomal protein L11 methyltransferase 168390 1195883 BMEI0171 Brucella melitensis bv. 1 str. 16M 50S ribosomal protein L11 methyltransferase NP_539089.1 167734 R 224914 CDS NP_539090.1 17986456 1195884 complement(168390..168818) 1 NC_003317.1 hypothetical protein 168818 1195884 BMEI0172 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539090.1 168390 R 224914 CDS NP_539091.1 17986457 1195885 complement(168831..169121) 1 NC_003317.1 unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity; hypothetical protein 169121 1195885 BMEI0173 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539091.1 168831 R 224914 CDS NP_539092.1 17986458 1195886 complement(169123..170103) 1 NC_003317.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 170103 gpsA 1195886 gpsA Brucella melitensis bv. 1 str. 16M NAD(P)H-dependent glycerol-3-phosphate dehydrogenase NP_539092.1 169123 R 224914 CDS NP_539093.1 17986459 1195887 complement(170100..171179) 1 NC_003317.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease 171179 1195887 BMEI0175 Brucella melitensis bv. 1 str. 16M DNA-binding/iron metalloprotein/AP endonuclease NP_539093.1 170100 R 224914 CDS NP_539094.1 17986460 1195888 171214..172242 1 NC_003317.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase 172242 hemC 1195888 hemC Brucella melitensis bv. 1 str. 16M porphobilinogen deaminase NP_539094.1 171214 D 224914 CDS NP_539095.1 17986461 1195889 172266..172973 1 NC_003317.1 catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; uroporphyrinogen-III synthase 172973 1195889 BMEI0177 Brucella melitensis bv. 1 str. 16M uroporphyrinogen-III synthase NP_539095.1 172266 D 224914 CDS NP_539096.1 17986462 1195890 173899..174432 1 NC_003317.1 hypothetical protein 174432 1195890 BMEI0178 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539096.1 173899 D 224914 CDS NP_539097.1 17986463 1195891 174439..176016 1 NC_003317.1 hypothetical protein 176016 1195891 BMEI0179 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539097.1 174439 D 224914 CDS NP_539098.1 17986464 1195892 176432..176911 1 NC_003317.1 hypothetical protein 176911 1195892 BMEI0180 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539098.1 176432 D 224914 CDS NP_539099.1 17986465 1195893 complement(176937..178175) 1 NC_003317.1 macrolide-efflux protein 178175 1195893 BMEI0181 Brucella melitensis bv. 1 str. 16M macrolide-efflux protein NP_539099.1 176937 R 224914 CDS NP_539100.1 17986466 1195894 complement(178314..179207) 1 NC_003317.1 biotin synthesis protein BioC 179207 1195894 BMEI0182 Brucella melitensis bv. 1 str. 16M biotin synthesis protein BioC NP_539100.1 178314 R 224914 CDS NP_539101.1 17986467 1195895 179390..180178 1 NC_003317.1 competence protein F 180178 1195895 BMEI0183 Brucella melitensis bv. 1 str. 16M competence protein F NP_539101.1 179390 D 224914 CDS NP_539102.1 17986468 1195896 180250..180528 1 NC_003317.1 glutaredoxin 180528 1195896 BMEI0184 Brucella melitensis bv. 1 str. 16M glutaredoxin NP_539102.1 180250 D 224914 CDS NP_539103.1 17986469 1195897 180539..181393 1 NC_003317.1 beta-ureidopropionase 181393 1195897 BMEI0185 Brucella melitensis bv. 1 str. 16M beta-ureidopropionase NP_539103.1 180539 D 224914 CDS NP_539104.1 17986470 1195898 181399..181824 1 NC_003317.1 hypothetical protein 181824 1195898 BMEI0186 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539104.1 181399 D 224914 CDS NP_539105.1 17986471 1195899 181852..182745 1 NC_003317.1 transporter, DME family 182745 1195899 BMEI0187 Brucella melitensis bv. 1 str. 16M transporter, DME family NP_539105.1 181852 D 224914 CDS NP_539106.1 17986472 1195900 complement(182751..183497) 1 NC_003317.1 Involved in ubiquinone biosynthesis; 3-demethylubiquinone-9 3-methyltransferase 183497 1195900 BMEI0188 Brucella melitensis bv. 1 str. 16M 3-demethylubiquinone-9 3-methyltransferase NP_539106.1 182751 R 224914 CDS NP_539107.1 17986473 1195901 183715..184986 1 NC_003317.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation.; aspartate kinase 184986 1195901 BMEI0189 Brucella melitensis bv. 1 str. 16M aspartate kinase NP_539107.1 183715 D 224914 CDS NP_539108.1 17986474 1195902 185314..187584 1 NC_003317.1 phosphoenolpyruvate-protein phosphotransferase PTSP 187584 1195902 BMEI0190 Brucella melitensis bv. 1 str. 16M phosphoenolpyruvate-protein phosphotransferase PTSP NP_539108.1 185314 D 224914 CDS NP_539109.2 161511164 1195903 187781..188860 1 NC_003317.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 188860 prfA 1195903 prfA Brucella melitensis bv. 1 str. 16M peptide chain release factor 1 NP_539109.2 187781 D 224914 CDS NP_539110.1 17986476 1195904 188857..189744 1 NC_003317.1 methyltransferase 189744 1195904 BMEI0192 Brucella melitensis bv. 1 str. 16M methyltransferase NP_539110.1 188857 D 224914 CDS NP_539111.1 17986477 1195905 189936..190208 1 NC_003317.1 hypothetical protein 190208 1195905 BMEI0193 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539111.1 189936 D 224914 CDS NP_539112.1 17986478 1195906 190189..190947 1 NC_003317.1 hypothetical protein 190947 1195906 BMEI0194 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539112.1 190189 D 224914 CDS NP_539113.1 17986479 1195907 190975..193770 1 NC_003317.1 ATP-dependent Clp protease, ATP-binding subunit CLPB 193770 1195907 BMEI0195 Brucella melitensis bv. 1 str. 16M ATP-dependent Clp protease, ATP-binding subunit CLPB NP_539113.1 190975 D 224914 CDS NP_539114.1 17986480 1195908 194810..195670 1 NC_003317.1 protein ERFK/SRFK 195670 1195908 BMEI0196 Brucella melitensis bv. 1 str. 16M protein ERFK/SRFK NP_539114.1 194810 D 224914 CDS NP_539115.1 17986481 1195909 complement(195738..197693) 1 NC_003317.1 lysostaphin 197693 1195909 BMEI0197 Brucella melitensis bv. 1 str. 16M lysostaphin NP_539115.1 195738 R 224914 CDS NP_539116.1 17986482 1195910 204832..205506 1 NC_003317.1 hypothetical protein 205506 1195910 BMEI0198 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539116.1 204832 D 224914 CDS NP_539117.1 17986483 1195911 205682..207121 1 NC_003317.1 hypothetical protein 207121 1195911 BMEI0199 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539117.1 205682 D 224914 CDS NP_539118.1 17986484 1195912 complement(207366..208187) 1 NC_003317.1 transposase 208187 1195912 BMEI0200 Brucella melitensis bv. 1 str. 16M transposase NP_539118.1 207366 R 224914 CDS NP_539119.2 161511163 1195913 208762..209190 1 NC_003317.1 50S ribosomal protein L21 209190 rplU 1195913 rplU Brucella melitensis bv. 1 str. 16M 50S ribosomal protein L21 NP_539119.2 208762 D 224914 CDS NP_539120.1 17986486 1195914 209284..209487 1 NC_003317.1 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 209487 rpmA 1195914 rpmA Brucella melitensis bv. 1 str. 16M 50S ribosomal protein L27 NP_539120.1 209284 D 224914 CDS NP_539121.1 17986487 1195915 209704..210048 1 NC_003317.1 acetyltransferase 210048 1195915 BMEI0203 Brucella melitensis bv. 1 str. 16M acetyltransferase NP_539121.1 209704 D 224914 CDS NP_539122.1 17986488 1195916 210311..210868 1 NC_003317.1 acetyltransferase 210868 1195916 BMEI0204 Brucella melitensis bv. 1 str. 16M acetyltransferase NP_539122.1 210311 D 224914 CDS NP_539123.1 17986489 1195917 211391..211858 1 NC_003317.1 immunoglobulin-binding protein EIBE 211858 1195917 BMEI0205 Brucella melitensis bv. 1 str. 16M immunoglobulin-binding protein EIBE NP_539123.1 211391 D 224914 CDS NP_539124.2 161511162 1195918 212114..213139 1 NC_003317.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 213139 obgE 1195918 obgE Brucella melitensis bv. 1 str. 16M GTPase ObgE NP_539124.2 212114 D 224914 CDS NP_539125.1 17986491 1195919 213167..214303 1 NC_003317.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 214303 1195919 BMEI0207 Brucella melitensis bv. 1 str. 16M gamma-glutamyl kinase NP_539125.1 213167 D 224914 CDS NP_539126.1 17986492 1195920 214316..215596 1 NC_003317.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 215596 proA 1195920 proA Brucella melitensis bv. 1 str. 16M gamma-glutamyl phosphate reductase NP_539126.1 214316 D 224914 CDS NP_539127.1 17986493 1195921 215596..216270 1 NC_003317.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase 216270 nadD 1195921 nadD Brucella melitensis bv. 1 str. 16M nicotinic acid mononucleotide adenylyltransferase NP_539127.1 215596 D 224914 CDS NP_539128.1 17986494 1195922 216334..216804 1 NC_003317.1 iojap superfamily protein 216804 1195922 BMEI0210 Brucella melitensis bv. 1 str. 16M iojap superfamily protein NP_539128.1 216334 D 224914 CDS NP_539129.1 17986495 1195923 216823..217347 1 NC_003317.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase 217347 1195923 BMEI0211 Brucella melitensis bv. 1 str. 16M rRNA large subunit methyltransferase NP_539129.1 216823 D 224914 CDS NP_539130.1 17986496 1195924 217465..218364 1 NC_003317.1 hypothetical protein 218364 1195924 BMEI0212 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539130.1 217465 D 224914 CDS NP_539131.1 17986497 1195925 218477..219826 1 NC_003317.1 metalloendopeptidase-like membrane protein 219826 1195925 BMEI0213 Brucella melitensis bv. 1 str. 16M metalloendopeptidase-like membrane protein NP_539131.1 218477 D 224914 CDS NP_539132.1 17986498 1195926 219816..221144 1 NC_003317.1 tail-specific protease 221144 1195926 BMEI0214 Brucella melitensis bv. 1 str. 16M tail-specific protease NP_539132.1 219816 D 224914 CDS NP_539133.1 17986499 1195927 221343..221879 1 NC_003317.1 hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase 221879 1195927 BMEI0215 Brucella melitensis bv. 1 str. 16M dinucleoside polyphosphate hydrolase NP_539133.1 221343 D 224914 CDS NP_539134.1 17986500 1195928 221995..222249 1 NC_003317.1 hypothetical protein 222249 1195928 BMEI0216 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539134.1 221995 D 224914 CDS NP_539135.1 17986501 1195929 222317..222961 1 NC_003317.1 hypothetical protein 222961 1195929 BMEI0217 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539135.1 222317 D 224914 CDS NP_539136.1 17986502 1195930 complement(223277..224203) 1 NC_003317.1 LysR family transcriptional regulator 224203 1195930 BMEI0218 Brucella melitensis bv. 1 str. 16M LysR family transcriptional regulator NP_539136.1 223277 R 224914 CDS NP_539137.1 17986503 1195931 224310..225806 1 NC_003317.1 malonate-semialdehyde dehydrogenase (acylating) / methylmalonate-semialdehyde dehydrogenase (acylating) 225806 1195931 BMEI0219 Brucella melitensis bv. 1 str. 16M malonate-semialdehyde dehydrogenase (acylating) / methylmalonate-semialdehyde dehydrogenase (acylating) NP_539137.1 224310 D 224914 CDS NP_539138.1 17986504 1195932 226020..226367 1 NC_003317.1 hypothetical protein 226367 1195932 BMEI0220 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539138.1 226020 D 224914 CDS NP_539139.1 17986505 1195933 226369..227265 1 NC_003317.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxamine kinase 227265 1195933 BMEI0221 Brucella melitensis bv. 1 str. 16M pyridoxamine kinase NP_539139.1 226369 D 224914 CDS NP_539140.1 17986506 1195934 227439..228080 1 NC_003317.1 carbonic anhydrase 228080 1195934 BMEI0222 Brucella melitensis bv. 1 str. 16M carbonic anhydrase NP_539140.1 227439 D 224914 CDS NP_539141.1 17986507 1195935 complement(228144..228911) 1 NC_003317.1 membrane-bound lytic murein transglycosylase B 228911 1195935 BMEI0223 Brucella melitensis bv. 1 str. 16M membrane-bound lytic murein transglycosylase B NP_539141.1 228144 R 224914 CDS NP_539142.1 17986508 1195936 complement(228911..229282) 1 NC_003317.1 hypothetical protein 229282 1195936 BMEI0224 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539142.1 228911 R 224914 CDS NP_539143.1 17986509 1195937 229406..230977 1 NC_003317.1 signal recognition particle subunit FFH/SRP54 230977 1195937 BMEI0225 Brucella melitensis bv. 1 str. 16M signal recognition particle subunit FFH/SRP54 NP_539143.1 229406 D 224914 CDS NP_539144.1 17986510 1195938 230983..231264 1 NC_003317.1 catalyzes the interconversion of chorismate to prephenate; chorismate mutase 231264 1195938 BMEI0226 Brucella melitensis bv. 1 str. 16M chorismate mutase NP_539144.1 230983 D 224914 CDS NP_539145.1 17986511 1195939 231365..231769 1 NC_003317.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 231769 rpsP 1195939 rpsP Brucella melitensis bv. 1 str. 16M 30S ribosomal protein S16 NP_539145.1 231365 D 224914 CDS NP_539146.1 17986512 1195940 232039..232662 1 NC_003317.1 LemA protein 232662 1195940 BMEI0228 Brucella melitensis bv. 1 str. 16M LemA protein NP_539146.1 232039 D 224914 CDS NP_539147.1 17986513 1195941 232749..233510 1 NC_003317.1 hypothetical protein 233510 1195941 BMEI0229 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539147.1 232749 D 224914 CDS NP_539148.1 17986514 1195942 233523..234164 1 NC_003317.1 hypothetical protein 234164 1195942 BMEI0230 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539148.1 233523 D 224914 CDS NP_539149.1 17986515 1195943 234429..239231 1 NC_003317.1 NAD-specific glutamate dehydrogenase 239231 1195943 BMEI0231 Brucella melitensis bv. 1 str. 16M NAD-specific glutamate dehydrogenase NP_539149.1 234429 D 224914 CDS NP_539150.1 17986516 1195944 239373..240818 1 NC_003317.1 transporter 240818 1195944 BMEI0232 Brucella melitensis bv. 1 str. 16M transporter NP_539150.1 239373 D 224914 CDS NP_539151.1 17986517 1195945 complement(240868..242484) 1 NC_003317.1 involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 242484 purH 1195945 purH Brucella melitensis bv. 1 str. 16M bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase NP_539151.1 240868 R 224914 CDS NP_539152.1 17986518 1195946 complement(242591..244306) 1 NC_003317.1 hypothetical protein 244306 1195946 BMEI0234 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539152.1 242591 R 224914 CDS NP_539153.1 17986519 1195947 complement(244454..245728) 1 NC_003317.1 16S rRNA m(5)C 967 methyltransferase 245728 1195947 BMEI0235 Brucella melitensis bv. 1 str. 16M 16S rRNA m(5)C 967 methyltransferase NP_539153.1 244454 R 224914 CDS NP_539154.1 17986520 1195948 complement(245867..246880) 1 NC_003317.1 metalloprotease; heat shock protein HtpX 246880 1195948 BMEI0236 Brucella melitensis bv. 1 str. 16M heat shock protein HtpX NP_539154.1 245867 R 224914 CDS NP_539155.1 17986521 1195949 246976..247194 1 NC_003317.1 hypothetical protein 247194 1195949 BMEI0237 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539155.1 246976 D 224914 CDS NP_539156.2 161511161 1195950 complement(247350..249305) 1 NC_003317.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA; acetyl-CoA synthetase 249305 1195950 BMEI0238 Brucella melitensis bv. 1 str. 16M acetyl-CoA synthetase NP_539156.2 247350 R 224914 CDS NP_539157.1 17986523 1195951 249661..249933 1 NC_003317.1 phosphoribosylanthranilate isomerase subunit 249933 1195951 BMEI0239 Brucella melitensis bv. 1 str. 16M phosphoribosylanthranilate isomerase subunit NP_539157.1 249661 D 224914 CDS NP_539158.1 17986524 1195952 250004..250534 1 NC_003317.1 fusaric acid resistance protein FusB / fusaric acid resistance protein FusC 250534 1195952 BMEI0240 Brucella melitensis bv. 1 str. 16M fusaric acid resistance protein FusB / fusaric acid resistance protein FusC NP_539158.1 250004 D 224914 CDS NP_539159.1 17986525 1195953 complement(250547..251227) 1 NC_003317.1 phosphate regulon sensor protein PHOR 251227 1195953 BMEI0241 Brucella melitensis bv. 1 str. 16M phosphate regulon sensor protein PHOR NP_539159.1 250547 R 224914 CDS NP_539160.1 17986526 1195954 251350..253983 1 NC_003317.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 253983 leuS 1195954 leuS Brucella melitensis bv. 1 str. 16M leucyl-tRNA synthetase NP_539160.1 251350 D 224914 CDS NP_539161.1 17986527 1195955 254129..254551 1 NC_003317.1 hypothetical protein 254551 1195955 BMEI0243 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539161.1 254129 D 224914 CDS NP_539162.1 17986528 1195956 complement(254694..255347) 1 NC_003317.1 similar to novel fructose-6-phosphate aldolase from Escherichia coli; enzyme from Methanocaldococcus janaschii shows transaldolase activity; translaldolase 255347 1195956 BMEI0244 Brucella melitensis bv. 1 str. 16M translaldolase NP_539162.1 254694 R 224914 CDS NP_539163.1 17986529 1195957 255457..256461 1 NC_003317.1 primosomal protein N' 256461 1195957 BMEI0245 Brucella melitensis bv. 1 str. 16M primosomal protein N' NP_539163.1 255457 D 224914 CDS NP_539164.1 17986530 1195958 256304..257692 1 NC_003317.1 primosomal protein N' 257692 1195958 BMEI0246 Brucella melitensis bv. 1 str. 16M primosomal protein N' NP_539164.1 256304 D 224914 CDS NP_539165.1 17986531 1195959 257816..258172 1 NC_003317.1 hypothetical protein 258172 1195959 BMEI0247 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539165.1 257816 D 224914 CDS NP_539166.1 17986532 1195960 258454..259014 1 NC_003317.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; ATP synthase F0F1 subunit delta 259014 1195960 BMEI0248 Brucella melitensis bv. 1 str. 16M ATP synthase F0F1 subunit delta NP_539166.1 258454 D 224914 CDS NP_539167.1 17986533 1195961 259014..260543 1 NC_003317.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; ATP synthase F0F1 subunit alpha 260543 1195961 BMEI0249 Brucella melitensis bv. 1 str. 16M ATP synthase F0F1 subunit alpha NP_539167.1 259014 D 224914 CDS NP_539168.1 17986534 1195962 260565..261443 1 NC_003317.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; ATP synthase F0F1 subunit gamma 261443 1195962 BMEI0250 Brucella melitensis bv. 1 str. 16M ATP synthase F0F1 subunit gamma NP_539168.1 260565 D 224914 CDS NP_539169.1 17986535 1195963 261571..263136 1 NC_003317.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; ATP synthase F0F1 subunit beta 263136 1195963 BMEI0251 Brucella melitensis bv. 1 str. 16M ATP synthase F0F1 subunit beta NP_539169.1 261571 D 224914 CDS NP_539170.1 17986536 1195964 263261..263668 1 NC_003317.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; ATP synthase F0F1 subunit epsilon 263668 atpC 1195964 atpC Brucella melitensis bv. 1 str. 16M ATP synthase F0F1 subunit epsilon NP_539170.1 263261 D 224914 CDS NP_539171.1 17986537 1195965 264038..264448 1 NC_003317.1 MarR family transcriptional regulator 264448 1195965 BMEI0253 Brucella melitensis bv. 1 str. 16M MarR family transcriptional regulator NP_539171.1 264038 D 224914 CDS NP_539172.1 17986538 1195966 complement(264521..265216) 1 NC_003317.1 GntR family transcriptional regulator 265216 1195966 BMEI0254 Brucella melitensis bv. 1 str. 16M GntR family transcriptional regulator NP_539172.1 264521 R 224914 CDS NP_539173.1 17986539 1195967 complement(265272..265511) 1 NC_003317.1 hypothetical protein 265511 1195967 BMEI0255 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539173.1 265272 R 224914 CDS NP_539174.1 17986540 1195968 265496..266758 1 NC_003317.1 D-amino acid dehydrogenase small subunit 266758 1195968 BMEI0256 Brucella melitensis bv. 1 str. 16M D-amino acid dehydrogenase small subunit NP_539174.1 265496 D 224914 CDS NP_539175.1 17986541 1195969 266764..267765 1 NC_003317.1 hydroxyproline-2-epimerase 267765 1195969 BMEI0257 Brucella melitensis bv. 1 str. 16M hydroxyproline-2-epimerase NP_539175.1 266764 D 224914 CDS NP_539176.1 17986542 1195970 268044..268967 1 NC_003317.1 high-affinity branched-chain amino acid transport system permease livH 268967 1195970 BMEI0258 Brucella melitensis bv. 1 str. 16M high-affinity branched-chain amino acid transport system permease livH NP_539176.1 268044 D 224914 CDS NP_539177.1 17986543 1195971 268970..270349 1 NC_003317.1 high-affinity branched-chain amino acid transport system permease LIVM 270349 1195971 BMEI0259 Brucella melitensis bv. 1 str. 16M high-affinity branched-chain amino acid transport system permease LIVM NP_539177.1 268970 D 224914 CDS NP_539178.1 17986544 1195972 270349..271689 1 NC_003317.1 high-affinity branched-chain amino acid transport ATP-binding protein BRAF 271689 1195972 BMEI0260 Brucella melitensis bv. 1 str. 16M high-affinity branched-chain amino acid transport ATP-binding protein BRAF NP_539178.1 270349 D 224914 CDS NP_539179.1 17986545 1195973 271686..272435 1 NC_003317.1 high-affinity branched-chain amino acid transport ATP-binding protein BRAG 272435 1195973 BMEI0261 Brucella melitensis bv. 1 str. 16M high-affinity branched-chain amino acid transport ATP-binding protein BRAG NP_539179.1 271686 D 224914 CDS NP_539180.1 17986546 1195974 272445..272789 1 NC_003317.1 hypothetical protein 272789 1195974 BMEI0262 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539180.1 272445 D 224914 CDS NP_539181.1 17986547 1195975 272926..274056 1 NC_003317.1 leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein precursor 274056 1195975 BMEI0263 Brucella melitensis bv. 1 str. 16M leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein precursor NP_539181.1 272926 D 224914 CDS NP_539182.1 17986548 1195976 274560..275135 1 NC_003317.1 leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein precursor 275135 1195976 BMEI0264 Brucella melitensis bv. 1 str. 16M leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein precursor NP_539182.1 274560 D 224914 CDS NP_539183.1 17986549 1195977 275136..275792 1 NC_003317.1 leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein precursor 275792 1195977 BMEI0265 Brucella melitensis bv. 1 str. 16M leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein precursor NP_539183.1 275136 D 224914 CDS NP_539184.1 17986550 1195978 276058..279534 1 NC_003317.1 biotin-containing enzyme that catalyzes a two step carboxylation of pyruvate to oxaloacetate; pyruvate carboxylase 279534 1195978 BMEI0266 Brucella melitensis bv. 1 str. 16M pyruvate carboxylase NP_539184.1 276058 D 224914 CDS NP_539185.1 17986551 1195979 279596..280789 1 NC_003317.1 hypothetical protein 280789 1195979 BMEI0267 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539185.1 279596 D 224914 CDS NP_539186.1 17986552 1195980 complement(280807..281622) 1 NC_003317.1 D-beta-hydroxybutyrate dehydrogenase 281622 1195980 BMEI0268 Brucella melitensis bv. 1 str. 16M D-beta-hydroxybutyrate dehydrogenase NP_539186.1 280807 R 224914 CDS NP_539187.1 17986553 1195981 281715..283028 1 NC_003317.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 283028 ispG 1195981 ispG Brucella melitensis bv. 1 str. 16M 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase NP_539187.1 281715 D 224914 CDS NP_539188.1 17986554 1195982 complement(283036..283950) 1 NC_003317.1 geranyltranstransferase 283950 1195982 BMEI0270 Brucella melitensis bv. 1 str. 16M geranyltranstransferase NP_539188.1 283036 R 224914 CDS NP_539189.1 17986555 1195983 284236..284871 1 NC_003317.1 glycosyltransferase; polymerizes glycan strands in the peptidoglycan; monofunctional biosynthetic peptidoglycan transglycosylase 284871 mtgA 1195983 mtgA Brucella melitensis bv. 1 str. 16M monofunctional biosynthetic peptidoglycan transglycosylase NP_539189.1 284236 D 224914 CDS NP_539190.1 17986556 1195984 285032..285211 1 NC_003317.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 285211 rpmF 1195984 rpmF Brucella melitensis bv. 1 str. 16M 50S ribosomal protein L32 NP_539190.1 285032 D 224914 CDS NP_539191.1 17986557 1195985 complement(285343..285774) 1 NC_003317.1 hypothetical protein 285774 1195985 BMEI0273 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539191.1 285343 R 224914 CDS NP_539192.1 17986558 1195986 285920..287434 1 NC_003317.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 287434 1195986 BMEI0274 Brucella melitensis bv. 1 str. 16M acetyl-CoA acetyltransferase NP_539192.1 285920 D 224914 CDS NP_539193.1 17986559 1195987 287527..290613 1 NC_003317.1 ATP-dependent DNA helicase 290613 1195987 BMEI0275 Brucella melitensis bv. 1 str. 16M ATP-dependent DNA helicase NP_539193.1 287527 D 224914 CDS NP_539194.1 17986560 1195988 290649..291050 1 NC_003317.1 heat shock protein 15 291050 1195988 BMEI0277 Brucella melitensis bv. 1 str. 16M heat shock protein 15 NP_539194.1 290649 D 224914 CDS NP_539195.1 17986561 1195989 291414..291752 1 NC_003317.1 ferredoxin II 291752 1195989 BMEI0278 Brucella melitensis bv. 1 str. 16M ferredoxin II NP_539195.1 291414 D 224914 CDS NP_539196.1 17986562 1195990 292222..292845 1 NC_003317.1 transcriptional regulator 292845 1195990 BMEI0279 Brucella melitensis bv. 1 str. 16M transcriptional regulator NP_539196.1 292222 D 224914 CDS NP_539197.1 17986563 1195991 293166..294125 1 NC_003317.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma-32 is responsible for the expression of heat shock promoters; there are paralogs in Rhizobium and Sinorhizobium; the proteins in this cluster act as secondary heat shock sigma factors; the Rhizobium sigma-32 factor may also be involved in exopolysaccharide production; RNA polymerase factor sigma-32 294125 rpoH2 1195991 rpoH2 Brucella melitensis bv. 1 str. 16M RNA polymerase factor sigma-32 NP_539197.1 293166 D 224914 CDS NP_539198.1 17986564 1195992 complement(294213..294941) 1 NC_003317.1 hypothetical protein 294941 1195992 BMEI0281 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539198.1 294213 R 224914 CDS NP_539199.1 17986565 1195993 complement(294968..296395) 1 NC_003317.1 zinc metalloprotease 296395 1195993 BMEI0282 Brucella melitensis bv. 1 str. 16M zinc metalloprotease NP_539199.1 294968 R 224914 CDS NP_539200.1 17986566 1195994 complement(296716..297504) 1 NC_003317.1 thiamine transport ATP-binding protein ThiQ 297504 1195994 BMEI0283 Brucella melitensis bv. 1 str. 16M thiamine transport ATP-binding protein ThiQ NP_539200.1 296716 R 224914 CDS NP_539201.1 17986567 1195995 complement(297438..299003) 1 NC_003317.1 permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine; thiamine transporter membrane protein 299003 thiP 1195995 thiP Brucella melitensis bv. 1 str. 16M thiamine transporter membrane protein NP_539201.1 297438 R 224914 CDS NP_539202.1 17986568 1195996 complement(299066..300073) 1 NC_003317.1 part of the thiamine and TPP transport system tbpA-thiPQ; thiamine transporter substrate binding subunit 300073 tbpA 1195996 tbpA Brucella melitensis bv. 1 str. 16M thiamine transporter substrate binding subunit NP_539202.1 299066 R 224914 CDS NP_539203.1 17986569 1195997 300377..301033 1 NC_003317.1 nucleotide-binding protein 301033 1195997 BMEI0286 Brucella melitensis bv. 1 str. 16M nucleotide-binding protein NP_539203.1 300377 D 224914 CDS NP_539204.1 17986570 1195998 301185..301451 1 NC_003317.1 hypothetical protein 301451 1195998 BMEI0287 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539204.1 301185 D 224914 CDS NP_539205.1 17986571 1195999 301587..303416 1 NC_003317.1 ABC transporter ATP-binding protein 303416 1195999 BMEI0288 Brucella melitensis bv. 1 str. 16M ABC transporter ATP-binding protein NP_539205.1 301587 D 224914 CDS NP_539206.1 17986572 1196000 complement(303508..303786) 1 NC_003317.1 hypothetical protein 303786 1196000 BMEI0289 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539206.1 303508 R 224914 CDS NP_539207.1 17986573 1196001 complement(303941..304759) 1 NC_003317.1 hypothetical protein 304759 1196001 BMEI0290 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539207.1 303941 R 224914 CDS NP_539208.1 17986574 1196002 305024..305461 1 NC_003317.1 hypothetical protein 305461 1196002 BMEI0291 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539208.1 305024 D 224914 CDS NP_539209.1 17986575 1196003 305458..306894 1 NC_003317.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 306894 1196003 BMEI0292 Brucella melitensis bv. 1 str. 16M pyruvate kinase NP_539209.1 305458 D 224914 CDS NP_539210.1 17986576 1196004 complement(307146..307817) 1 NC_003317.1 2-hydroxy-6-oxo-2,4-heptadienoate hydrolase 307817 1196004 BMEI0293 Brucella melitensis bv. 1 str. 16M 2-hydroxy-6-oxo-2,4-heptadienoate hydrolase NP_539210.1 307146 R 224914 CDS NP_539211.1 17986577 1196005 complement(307873..308067) 1 NC_003317.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group do not have the motif; 50S ribosomal protein L36 308067 rpmJ 1196005 rpmJ Brucella melitensis bv. 1 str. 16M 50S ribosomal protein L36 NP_539211.1 307873 R 224914 CDS NP_539212.1 17986578 1196006 complement(308234..309322) 1 NC_003317.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 309322 1196006 BMEI0295 Brucella melitensis bv. 1 str. 16M phosphoribosylaminoimidazole carboxylase ATPase subunit NP_539212.1 308234 R 224914 CDS NP_539213.1 17986579 1196007 complement(309339..309881) 1 NC_003317.1 phosphoribosylaminoimidazole carboxylase catalytic subunit 309881 1196007 BMEI0296 Brucella melitensis bv. 1 str. 16M phosphoribosylaminoimidazole carboxylase catalytic subunit NP_539213.1 309339 R 224914 CDS NP_539214.1 17986580 1196008 complement(309925..310170) 1 NC_003317.1 hypothetical protein 310170 1196008 BMEI0297 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539214.1 309925 R 224914 CDS NP_539215.1 17986581 1196009 310302..310463 1 NC_003317.1 hypothetical protein 310463 1196009 BMEI0298 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539215.1 310302 D 224914 CDS NP_539216.1 17986582 1196010 310522..310701 1 NC_003317.1 hypothetical protein 310701 1196010 BMEI0299 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539216.1 310522 D 224914 CDS NP_539217.1 17986583 1196011 complement(310844..312082) 1 NC_003317.1 major facilitator superfamily transporter 312082 1196011 BMEI0300 Brucella melitensis bv. 1 str. 16M major facilitator superfamily transporter NP_539217.1 310844 R 224914 CDS NP_539218.1 17986584 1196012 complement(312180..312371) 1 NC_003317.1 hypothetical protein 312371 1196012 BMEI0301 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539218.1 312180 R 224914 CDS NP_539219.1 17986585 1196013 312558..313568 1 NC_003317.1 quinone oxidoreductase 313568 1196013 BMEI0302 Brucella melitensis bv. 1 str. 16M quinone oxidoreductase NP_539219.1 312558 D 224914 CDS NP_539220.1 17986586 1196014 313696..314385 1 NC_003317.1 hypothetical protein 314385 1196014 BMEI0303 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539220.1 313696 D 224914 CDS NP_539221.1 17986587 1196015 complement(314463..314870) 1 NC_003317.1 hypothetical protein 314870 1196015 BMEI0304 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539221.1 314463 R 224914 CDS NP_539222.1 17986588 1196016 complement(315343..315975) 1 NC_003317.1 DeoR family transcriptional regulator 315975 1196016 BMEI0305 Brucella melitensis bv. 1 str. 16M DeoR family transcriptional regulator NP_539222.1 315343 R 224914 CDS NP_539223.1 17986589 1196017 complement(315982..316206) 1 NC_003317.1 hypothetical protein 316206 1196017 BMEI0306 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539223.1 315982 R 224914 CDS NP_539224.1 17986590 1196018 complement(316551..318542) 1 NC_003317.1 propionate-CoA ligase 318542 1196018 BMEI0307 Brucella melitensis bv. 1 str. 16M propionate-CoA ligase NP_539224.1 316551 R 224914 CDS NP_539225.1 17986591 1196019 318693..318899 1 NC_003317.1 hypothetical protein 318899 1196019 BMEI0308 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539225.1 318693 D 224914 CDS NP_539226.1 17986592 1196020 complement(319190..320404) 1 NC_003317.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 320404 pgk 1196020 pgk Brucella melitensis bv. 1 str. 16M phosphoglycerate kinase NP_539226.1 319190 R 224914 CDS NP_539227.1 17986593 1196021 complement(320448..321455) 1 NC_003317.1 catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; glyceraldehyde-3-phosphate dehydrogenase 321455 1196021 BMEI0310 Brucella melitensis bv. 1 str. 16M glyceraldehyde-3-phosphate dehydrogenase NP_539227.1 320448 R 224914 CDS NP_539228.1 17986594 1196022 complement(321596..323719) 1 NC_003317.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 323719 1196022 BMEI0311 Brucella melitensis bv. 1 str. 16M transketolase NP_539228.1 321596 R 224914 CDS NP_539229.1 17986595 1196023 324127..324276 1 NC_003317.1 hypothetical protein 324276 1196023 BMEI0312 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539229.1 324127 D 224914 CDS NP_539230.1 17986596 1196024 324286..324651 1 NC_003317.1 hypothetical protein 324651 1196024 BMEI0313 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539230.1 324286 D 224914 CDS NP_539231.1 17986597 1196025 324785..325015 1 NC_003317.1 hypothetical protein 325015 1196025 BMEI0314 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539231.1 324785 D 224914 CDS NP_539232.1 17986598 1196026 325090..325635 1 NC_003317.1 5-formyltetrahydrofolate cyclo-ligase 325635 1196026 BMEI0315 Brucella melitensis bv. 1 str. 16M 5-formyltetrahydrofolate cyclo-ligase NP_539232.1 325090 D 224914 CDS NP_539233.1 17986599 1196027 325744..326568 1 NC_003317.1 hypothetical protein 326568 1196027 BMEI0316 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539233.1 325744 D 224914 CDS NP_539234.1 17986600 1196028 326671..327522 1 NC_003317.1 hypothetical protein 327522 1196028 BMEI0317 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539234.1 326671 D 224914 CDS NP_539235.1 17986601 1196029 complement(327535..327963) 1 NC_003317.1 2Fe-2S ferredoxin 327963 1196029 BMEI0318 Brucella melitensis bv. 1 str. 16M 2Fe-2S ferredoxin NP_539235.1 327535 R 224914 CDS NP_539236.1 17986602 1196030 complement(327974..328549) 1 NC_003317.1 BioY protein 328549 1196030 BMEI0319 Brucella melitensis bv. 1 str. 16M BioY protein NP_539236.1 327974 R 224914 CDS NP_539237.1 17986603 1196031 complement(328711..329403) 1 NC_003317.1 GntR family transcriptional regulator 329403 1196031 BMEI0320 Brucella melitensis bv. 1 str. 16M GntR family transcriptional regulator NP_539237.1 328711 R 224914 CDS NP_539238.2 161511160 1196032 329624..330370 1 NC_003317.1 hypothetical protein 330370 1196032 BMEI0321 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539238.2 329624 D 224914 CDS NP_539239.1 17986605 1196033 complement(330598..330819) 1 NC_003317.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 330819 rpmE 1196033 rpmE Brucella melitensis bv. 1 str. 16M 50S ribosomal protein L31 NP_539239.1 330598 R 224914 CDS NP_539240.1 17986606 1196034 330994..332934 1 NC_003317.1 transport ATP-binding protein msbA 332934 1196034 BMEI0323 Brucella melitensis bv. 1 str. 16M transport ATP-binding protein msbA NP_539240.1 330994 D 224914 CDS NP_539241.1 17986607 1196035 complement(332968..333999) 1 NC_003317.1 hypothetical protein 333999 1196035 BMEI0324 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539241.1 332968 R 224914 CDS NP_539242.1 17986608 1196036 complement(334006..335046) 1 NC_003317.1 MotA/TolQ/ExbB proton channel family protein 335046 1196036 BMEI0325 Brucella melitensis bv. 1 str. 16M MotA/TolQ/ExbB proton channel family protein NP_539242.1 334006 R 224914 CDS NP_539243.1 17986609 1196037 complement(335310..336101) 1 NC_003317.1 myo-inositol-1(or 4)-monophosphatase 336101 1196037 BMEI0326 Brucella melitensis bv. 1 str. 16M myo-inositol-1(or 4)-monophosphatase NP_539243.1 335310 R 224914 CDS NP_539244.1 17986610 1196038 complement(336287..336847) 1 NC_003317.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 336847 1196038 BMEI0327 Brucella melitensis bv. 1 str. 16M elongation factor P NP_539244.1 336287 R 224914 CDS NP_539245.1 17986611 1196039 complement(337112..338008) 1 NC_003317.1 hypothetical protein 338008 1196039 BMEI0328 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539245.1 337112 R 224914 CDS NP_539246.1 17986612 1196040 complement(338201..338866) 1 NC_003317.1 catalyzes the formation of thiamine monophosphate from 2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate and 4-methyl-5-(2-phosphono-oxyethyl)-thiazole; thiamine-phosphate pyrophosphorylase 338866 1196040 BMEI0329 Brucella melitensis bv. 1 str. 16M thiamine-phosphate pyrophosphorylase NP_539246.1 338201 R 224914 CDS NP_539247.1 17986613 1196041 339090..340292 1 NC_003317.1 OPGC 340292 1196041 BMEI0330 Brucella melitensis bv. 1 str. 16M OPGC NP_539247.1 339090 D 224914 CDS NP_539248.1 17986614 1196042 340759..341286 1 NC_003317.1 hypothetical protein 341286 1196042 BMEI0331 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539248.1 340759 D 224914 CDS NP_539249.1 17986615 1196043 341388..341909 1 NC_003317.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 341909 ruvC 1196043 ruvC Brucella melitensis bv. 1 str. 16M Holliday junction resolvase NP_539249.1 341388 D 224914 CDS NP_539250.1 17986616 1196044 341914..342531 1 NC_003317.1 plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 342531 ruvA 1196044 ruvA Brucella melitensis bv. 1 str. 16M Holliday junction DNA helicase RuvA NP_539250.1 341914 D 224914 CDS NP_539251.1 17986617 1196045 342572..343612 1 NC_003317.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 343612 ruvB 1196045 ruvB Brucella melitensis bv. 1 str. 16M Holliday junction DNA helicase RuvB NP_539251.1 342572 D 224914 CDS NP_539252.1 17986618 1196046 343609..344058 1 NC_003317.1 4-hydroxybenzoyl-CoA thioesterase 344058 1196046 BMEI0335 Brucella melitensis bv. 1 str. 16M 4-hydroxybenzoyl-CoA thioesterase NP_539252.1 343609 D 224914 CDS NP_539253.1 17986619 1196047 344433..345143 1 NC_003317.1 TOLQ protein 345143 1196047 BMEI0336 Brucella melitensis bv. 1 str. 16M TOLQ protein NP_539253.1 344433 D 224914 CDS NP_539254.1 17986620 1196048 345190..345642 1 NC_003317.1 biopolymer transport EXBD protein 345642 1196048 BMEI0337 Brucella melitensis bv. 1 str. 16M biopolymer transport EXBD protein NP_539254.1 345190 D 224914 CDS NP_539255.1 17986621 1196049 346178..346720 1 NC_003317.1 hypothetical protein 346720 1196049 BMEI0338 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539255.1 346178 D 224914 CDS NP_539256.1 17986622 1196050 346776..348107 1 NC_003317.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA; translocation protein TolB 348107 tolB 1196050 tolB Brucella melitensis bv. 1 str. 16M translocation protein TolB NP_539256.1 346776 D 224914 CDS NP_539257.1 17986623 1196051 348395..348901 1 NC_003317.1 peptidoglycan-associated lipoprotein 348901 1196051 BMEI0340 Brucella melitensis bv. 1 str. 16M peptidoglycan-associated lipoprotein NP_539257.1 348395 D 224914 CDS NP_539258.1 17986624 1196052 350180..350764 1 NC_003317.1 hypothetical protein 350764 1196052 BMEI0341 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539258.1 350180 D 224914 CDS NP_539259.1 17986625 1196053 350837..352126 1 NC_003317.1 cell cycle protein MESJ 352126 1196053 BMEI0342 Brucella melitensis bv. 1 str. 16M cell cycle protein MESJ NP_539259.1 350837 D 224914 CDS NP_539260.1 17986626 1196054 352241..354196 1 NC_003317.1 cell division protein FTSH 354196 1196054 BMEI0343 Brucella melitensis bv. 1 str. 16M cell division protein FTSH NP_539260.1 352241 D 224914 CDS NP_539261.1 17986627 1196055 354429..355856 1 NC_003317.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 355856 glmM 1196055 glmM Brucella melitensis bv. 1 str. 16M phosphoglucosamine mutase NP_539261.1 354429 D 224914 CDS NP_539262.1 17986628 1196056 356041..356865 1 NC_003317.1 heat resistant agglutinin 1 356865 1196056 BMEI0345 Brucella melitensis bv. 1 str. 16M heat resistant agglutinin 1 NP_539262.1 356041 D 224914 CDS NP_539263.1 17986629 1196057 357046..358002 1 NC_003317.1 sodium/bile acid cotransporter family protein 358002 1196057 BMEI0346 Brucella melitensis bv. 1 str. 16M sodium/bile acid cotransporter family protein NP_539263.1 357046 D 224914 CDS NP_539264.1 17986630 1196058 358153..359328 1 NC_003317.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; phosphoserine aminotransferase 359328 1196058 BMEI0347 Brucella melitensis bv. 1 str. 16M phosphoserine aminotransferase NP_539264.1 358153 D 224914 CDS NP_539265.1 17986631 1196059 359283..359471 1 NC_003317.1 hypothetical protein 359471 1196059 BMEI0348 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539265.1 359283 D 224914 CDS NP_539266.1 17986632 1196060 359468..361084 1 NC_003317.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase 361084 1196060 BMEI0349 Brucella melitensis bv. 1 str. 16M D-3-phosphoglycerate dehydrogenase NP_539266.1 359468 D 224914 CDS NP_539267.1 17986633 1196061 361101..361598 1 NC_003317.1 acetyltransferase 361598 1196061 BMEI0350 Brucella melitensis bv. 1 str. 16M acetyltransferase NP_539267.1 361101 D 224914 CDS NP_539268.1 17986634 1196062 361643..363205 1 NC_003317.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 363205 1196062 BMEI0351 Brucella melitensis bv. 1 str. 16M adenylosuccinate synthetase NP_539268.1 361643 D 224914 CDS NP_539269.1 17986635 1196063 364382..364915 1 NC_003317.1 transcriptional regulator 364915 1196063 BMEI0352 Brucella melitensis bv. 1 str. 16M transcriptional regulator NP_539269.1 364382 D 224914 CDS NP_539270.1 17986636 1196064 complement(365125..366636) 1 NC_003317.1 proline/betaine transporter 366636 1196064 BMEI0353 Brucella melitensis bv. 1 str. 16M proline/betaine transporter NP_539270.1 365125 R 224914 CDS NP_539271.1 17986637 1196065 366840..367655 1 NC_003317.1 hypothetical protein 367655 1196065 BMEI0354 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539271.1 366840 D 224914 CDS NP_539272.1 17986638 1196066 complement(367682..368515) 1 NC_003317.1 glutamine amidotransferase 368515 1196066 BMEI0355 Brucella melitensis bv. 1 str. 16M glutamine amidotransferase NP_539272.1 367682 R 224914 CDS NP_539273.1 17986639 1196067 complement(368586..368801) 1 NC_003317.1 Type 1 capsular polysaccharide biosynthesis protein J 368801 1196067 BMEI0356 Brucella melitensis bv. 1 str. 16M Type 1 capsular polysaccharide biosynthesis protein J NP_539273.1 368586 R 224914 CDS NP_539274.1 17986640 1196068 368911..369417 1 NC_003317.1 AsnC family transcriptional regulator 369417 1196068 BMEI0357 Brucella melitensis bv. 1 str. 16M AsnC family transcriptional regulator NP_539274.1 368911 D 224914 CDS NP_539275.1 17986641 1196069 369590..370114 1 NC_003317.1 catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 370114 dut 1196069 dut Brucella melitensis bv. 1 str. 16M deoxyuridine 5'-triphosphate nucleotidohydrolase NP_539275.1 369590 D 224914 CDS NP_539276.1 17986642 1196070 370349..371575 1 NC_003317.1 periplasmic protein of efflux system 371575 1196070 BMEI0359 Brucella melitensis bv. 1 str. 16M periplasmic protein of efflux system NP_539276.1 370349 D 224914 CDS NP_539277.1 17986643 1196071 371575..372720 1 NC_003317.1 ABC transporter ATP-binding protein 372720 1196071 BMEI0360 Brucella melitensis bv. 1 str. 16M ABC transporter ATP-binding protein NP_539277.1 371575 D 224914 CDS NP_539278.1 17986644 1196072 372729..373529 1 NC_003317.1 ABC transporter ATP-binding protein 373529 1196072 BMEI0361 Brucella melitensis bv. 1 str. 16M ABC transporter ATP-binding protein NP_539278.1 372729 D 224914 CDS NP_539279.1 17986645 1196073 373548..374318 1 NC_003317.1 hypothetical protein 374318 1196073 BMEI0362 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539279.1 373548 D 224914 CDS NP_539280.1 17986646 1196074 complement(374361..374708) 1 NC_003317.1 TonB protein 374708 1196074 BMEI0363 Brucella melitensis bv. 1 str. 16M TonB protein NP_539280.1 374361 R 224914 CDS NP_539281.1 17986647 1196075 complement(375179..375703) 1 NC_003317.1 biopolymer transport EXBD protein 375703 1196075 BMEI0364 Brucella melitensis bv. 1 str. 16M biopolymer transport EXBD protein NP_539281.1 375179 R 224914 CDS NP_539282.1 17986648 1196076 complement(375709..376581) 1 NC_003317.1 biopolymer transport EXBB protein 376581 1196076 BMEI0365 Brucella melitensis bv. 1 str. 16M biopolymer transport EXBB protein NP_539282.1 375709 R 224914 CDS NP_539283.1 17986649 1196077 377414..377881 1 NC_003317.1 hypothetical protein 377881 1196077 BMEI0366 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539283.1 377414 D 224914 CDS NP_539284.1 17986650 1196078 377917..378255 1 NC_003317.1 hypothetical protein 378255 1196078 BMEI0367 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539284.1 377917 D 224914 CDS NP_539285.1 17986651 1196079 378420..378773 1 NC_003317.1 hypothetical protein 378773 1196079 BMEI0368 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539285.1 378420 D 224914 CDS NP_539286.1 17986652 1196080 378782..379213 1 NC_003317.1 hypothetical protein 379213 1196080 BMEI0369 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539286.1 378782 D 224914 CDS NP_539287.1 17986653 1196081 complement(379274..380068) 1 NC_003317.1 sensory transduction histidine kinase 380068 1196081 BMEI0370 Brucella melitensis bv. 1 str. 16M sensory transduction histidine kinase NP_539287.1 379274 R 224914 CDS NP_539288.1 17986654 1196082 complement(380916..381488) 1 NC_003317.1 Bacteria have multiple sigma factors which are active under specific conditions; the sigma factor binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; RNA polymerase sigma factor 381488 1196082 BMEI0371 Brucella melitensis bv. 1 str. 16M RNA polymerase sigma factor NP_539288.1 380916 R 224914 CDS NP_539289.1 17986655 1196083 381933..382727 1 NC_003317.1 in Caulobacter crescentus, CC3477 is differentially expressed in minimal salts media with glucose as compared to complex media; two-component response regulator 382727 1196083 BMEI0372 Brucella melitensis bv. 1 str. 16M two-component response regulator NP_539289.1 381933 D 224914 CDS NP_539290.1 17986656 1196084 382889..383041 1 NC_003317.1 hypothetical protein 383041 1196084 BMEI0373 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539290.1 382889 D 224914 CDS NP_539291.1 17986657 1196085 383237..384244 1 NC_003317.1 sensory transduction histidine kinase 384244 1196085 BMEI0374 Brucella melitensis bv. 1 str. 16M sensory transduction histidine kinase NP_539291.1 383237 D 224914 CDS NP_539292.1 17986658 1196086 complement(384480..384920) 1 NC_003317.1 ferric uptake regulation protein 384920 1196086 BMEI0375 Brucella melitensis bv. 1 str. 16M ferric uptake regulation protein NP_539292.1 384480 R 224914 CDS NP_539293.1 17986659 1196087 complement(385284..385760) 1 NC_003317.1 hypothetical protein 385760 1196087 BMEI0376 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539293.1 385284 R 224914 CDS NP_539294.1 17986660 1196088 385777..386820 1 NC_003317.1 ribosomal large subunit pseudouridine synthase D 386820 1196088 BMEI0377 Brucella melitensis bv. 1 str. 16M ribosomal large subunit pseudouridine synthase D NP_539294.1 385777 D 224914 CDS NP_539295.1 17986661 1196089 387251..388162 1 NC_003317.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters; RNA polymerase factor sigma-32 388162 1196089 BMEI0378 Brucella melitensis bv. 1 str. 16M RNA polymerase factor sigma-32 NP_539295.1 387251 D 224914 CDS NP_539296.1 17986662 1196090 complement(388221..388715) 1 NC_003317.1 phosphinothricin N-acetyltransferase 388715 1196090 BMEI0379 Brucella melitensis bv. 1 str. 16M phosphinothricin N-acetyltransferase NP_539296.1 388221 R 224914 CDS NP_539297.1 17986663 1196091 complement(389021..391207) 1 NC_003317.1 catalyzes the formation of malate from glyoxylate and acetyl-CoA; malate synthase G 391207 1196091 BMEI0380 Brucella melitensis bv. 1 str. 16M malate synthase G NP_539297.1 389021 R 224914 CDS NP_539298.1 17986664 1196092 complement(391350..392225) 1 NC_003317.1 this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu; glutamyl-Q tRNA(Asp) synthetase 392225 1196092 BMEI0381 Brucella melitensis bv. 1 str. 16M glutamyl-Q tRNA(Asp) synthetase NP_539298.1 391350 R 224914 CDS NP_539299.1 17986665 1196093 392271..392945 1 NC_003317.1 DNA-3-methyladenine glycosidase 392945 1196093 BMEI0382 Brucella melitensis bv. 1 str. 16M DNA-3-methyladenine glycosidase NP_539299.1 392271 D 224914 CDS NP_539300.1 17986666 1196094 393219..393791 1 NC_003317.1 5-methylcytosine-specific restriction protein A 393791 1196094 BMEI0383 Brucella melitensis bv. 1 str. 16M 5-methylcytosine-specific restriction protein A NP_539300.1 393219 D 224914 CDS NP_539301.1 17986667 1196095 complement(393808..394326) 1 NC_003317.1 disulfide bond formation protein B 394326 1196095 BMEI0384 Brucella melitensis bv. 1 str. 16M disulfide bond formation protein B NP_539301.1 393808 R 224914 CDS NP_539302.1 17986668 1196096 complement(394439..395029) 1 NC_003317.1 membrane-associated alkaline phosphatase 395029 1196096 BMEI0385 Brucella melitensis bv. 1 str. 16M membrane-associated alkaline phosphatase NP_539302.1 394439 R 224914 CDS NP_539303.1 17986669 1196097 complement(395134..396597) 1 NC_003317.1 succinate-semialdehyde dehydrogenase 396597 1196097 BMEI0386 Brucella melitensis bv. 1 str. 16M succinate-semialdehyde dehydrogenase NP_539303.1 395134 R 224914 CDS NP_539304.1 17986670 1196098 396715..397536 1 NC_003317.1 IclR family transcriptional regulator 397536 1196098 BMEI0387 Brucella melitensis bv. 1 str. 16M IclR family transcriptional regulator NP_539304.1 396715 D 224914 CDS NP_539305.1 17986671 1196099 complement(404235..405755) 1 NC_003317.1 choline dehydrogenase 405755 1196099 BMEI0388 Brucella melitensis bv. 1 str. 16M choline dehydrogenase NP_539305.1 404235 R 224914 CDS NP_539306.1 17986672 1196100 405880..406104 1 NC_003317.1 hypothetical protein 406104 1196100 BMEI0389 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539306.1 405880 D 224914 CDS NP_539307.1 17986673 1196101 complement(406254..406517) 1 NC_003317.1 hypothetical protein 406517 1196101 BMEI0390 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539307.1 406254 R 224914 CDS NP_539308.1 17986674 1196102 406815..408344 1 NC_003317.1 sugar transport ATP-binding protein 408344 1196102 BMEI0391 Brucella melitensis bv. 1 str. 16M sugar transport ATP-binding protein NP_539308.1 406815 D 224914 CDS NP_539309.1 17986675 1196103 408440..409444 1 NC_003317.1 ribose ABC transporter permease 409444 1196103 BMEI0392 Brucella melitensis bv. 1 str. 16M ribose ABC transporter permease NP_539309.1 408440 D 224914 CDS NP_539310.1 17986676 1196104 409632..410609 1 NC_003317.1 D-ribose-binding periplasmic protein precursor 410609 1196104 BMEI0393 Brucella melitensis bv. 1 str. 16M D-ribose-binding periplasmic protein precursor NP_539310.1 409632 D 224914 CDS NP_539311.1 17986677 1196105 410698..411174 1 NC_003317.1 2-deoxy-D-gluconate 3-dehydrogenase 411174 1196105 BMEI0394 Brucella melitensis bv. 1 str. 16M 2-deoxy-D-gluconate 3-dehydrogenase NP_539311.1 410698 D 224914 CDS NP_539312.1 17986678 1196106 411107..411475 1 NC_003317.1 2-deoxy-D-gluconate 3-dehydrogenase 411475 1196106 BMEI0395 Brucella melitensis bv. 1 str. 16M 2-deoxy-D-gluconate 3-dehydrogenase NP_539312.1 411107 D 224914 CDS NP_539313.1 17986679 1196107 411472..412500 1 NC_003317.1 dihydroxyacetone kinase 412500 1196107 BMEI0396 Brucella melitensis bv. 1 str. 16M dihydroxyacetone kinase NP_539313.1 411472 D 224914 CDS NP_539314.1 17986680 1196108 412497..413153 1 NC_003317.1 dihydroxyacetone kinase 413153 1196108 BMEI0397 Brucella melitensis bv. 1 str. 16M dihydroxyacetone kinase NP_539314.1 412497 D 224914 CDS NP_539315.1 17986681 1196109 413312..415396 1 NC_003317.1 deoxyribonucleoside regulator / dihydroxyacetone kinase 415396 1196109 BMEI0398 Brucella melitensis bv. 1 str. 16M deoxyribonucleoside regulator / dihydroxyacetone kinase NP_539315.1 413312 D 224914 CDS NP_539316.1 17986682 1196110 415414..416109 1 NC_003317.1 dihydroxyacetone kinase 416109 1196110 BMEI0399 Brucella melitensis bv. 1 str. 16M dihydroxyacetone kinase NP_539316.1 415414 D 224914 CDS NP_539317.1 17986683 1196111 complement(416386..416628) 1 NC_003317.1 hypothetical protein 416628 1196111 BMEI0400 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539317.1 416386 R 224914 CDS NP_539318.1 17986684 1196112 417340..418770 1 NC_003317.1 hypothetical protein 418770 1196112 BMEI0401 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539318.1 417340 D 224914 CDS NP_539319.1 17986685 1196113 complement(418899..419504) 1 NC_003317.1 hypothetical protein 419504 1196113 BMEI0402 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539319.1 418899 R 224914 CDS NP_539320.1 17986686 1196114 complement(419731..420345) 1 NC_003317.1 multiple antibiotic resistance protein MARC 420345 1196114 BMEI0403 Brucella melitensis bv. 1 str. 16M multiple antibiotic resistance protein MARC NP_539320.1 419731 R 224914 CDS NP_539321.1 17986687 1196115 complement(420361..422004) 1 NC_003317.1 hypothetical protein 422004 1196115 BMEI0404 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539321.1 420361 R 224914 CDS NP_539322.1 17986688 1196116 complement(422128..422922) 1 NC_003317.1 7-alpha-hydroxysteroid dehydrogenase 422922 1196116 BMEI0405 Brucella melitensis bv. 1 str. 16M 7-alpha-hydroxysteroid dehydrogenase NP_539322.1 422128 R 224914 CDS NP_539323.2 161511159 1196117 complement(422988..423755) 1 NC_003317.1 Acts on the hydroxyl group at position 7 of the steroid frame; 7-alpha-hydroxysteroid dehydrogenase 423755 1196117 BMEI0406 Brucella melitensis bv. 1 str. 16M 7-alpha-hydroxysteroid dehydrogenase NP_539323.2 422988 R 224914 CDS NP_539324.1 17986690 1196118 424223..424459 1 NC_003317.1 hypothetical protein 424459 1196118 BMEI0407 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539324.1 424223 D 224914 CDS NP_539325.1 17986691 1196119 complement(424718..424903) 1 NC_003317.1 hypothetical protein 424903 1196119 BMEI0408 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539325.1 424718 R 224914 CDS NP_539326.1 17986692 1196120 complement(424989..426278) 1 NC_003317.1 Catalyzes the first step in the glyoxalate cycle, which converts lipids to carbohydrates; isocitrate lyase 426278 1196120 BMEI0409 Brucella melitensis bv. 1 str. 16M isocitrate lyase NP_539326.1 424989 R 224914 CDS NP_539327.1 17986693 1196121 426671..427939 1 NC_003317.1 MerR family transcriptional regulator 427939 1196121 BMEI0410 Brucella melitensis bv. 1 str. 16M MerR family transcriptional regulator NP_539327.1 426671 D 224914 CDS NP_539328.1 17986694 1196122 428161..429264 1 NC_003317.1 putrescine-binding periplasmic protein 429264 1196122 BMEI0411 Brucella melitensis bv. 1 str. 16M putrescine-binding periplasmic protein NP_539328.1 428161 D 224914 CDS NP_539329.1 17986695 1196123 429506..430651 1 NC_003317.1 putrescine ABC transporter ATP-binding protein 430651 1196123 BMEI0412 Brucella melitensis bv. 1 str. 16M putrescine ABC transporter ATP-binding protein NP_539329.1 429506 D 224914 CDS NP_539330.1 17986696 1196124 430667..431578 1 NC_003317.1 putrescine ABC transporter permease 431578 1196124 BMEI0413 Brucella melitensis bv. 1 str. 16M putrescine ABC transporter permease NP_539330.1 430667 D 224914 CDS NP_539331.1 17986697 1196125 431580..432401 1 NC_003317.1 putrescine ABC transporter permease 432401 1196125 BMEI0414 Brucella melitensis bv. 1 str. 16M putrescine ABC transporter permease NP_539331.1 431580 D 224914 CDS NP_539332.1 17986698 1196126 complement(432409..434265) 1 NC_003317.1 hypothetical protein 434265 1196126 BMEI0415 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539332.1 432409 R 224914 CDS NP_539333.1 17986699 1196127 434490..434735 1 NC_003317.1 hypothetical protein 434735 1196127 BMEI0416 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539333.1 434490 D 224914 CDS NP_539334.1 17986700 1196128 complement(435087..437528) 1 NC_003317.1 non-motile and phage-resistance protein 437528 1196128 BMEI0417 Brucella melitensis bv. 1 str. 16M non-motile and phage-resistance protein NP_539334.1 435087 R 224914 CDS NP_539335.1 17986701 1196129 438915..439721 1 NC_003317.1 lipooligosaccharide biosynthesis protein lic2B 439721 1196129 BMEI0418 Brucella melitensis bv. 1 str. 16M lipooligosaccharide biosynthesis protein lic2B NP_539335.1 438915 D 224914 CDS NP_539336.1 17986702 1196130 complement(439897..440151) 1 NC_003317.1 hypothetical protein 440151 1196130 BMEI0419 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539336.1 439897 R 224914 CDS NP_539337.1 17986703 1196131 440511..441509 1 NC_003317.1 oxidoreductase 441509 1196131 BMEI0420 Brucella melitensis bv. 1 str. 16M oxidoreductase NP_539337.1 440511 D 224914 CDS NP_539338.1 17986704 1196132 441642..442793 1 NC_003317.1 pleiotropic regulatory protein 442793 1196132 BMEI0421 Brucella melitensis bv. 1 str. 16M pleiotropic regulatory protein NP_539338.1 441642 D 224914 CDS NP_539339.1 17986705 1196133 complement(442877..443269) 1 NC_003317.1 hypothetical protein 443269 1196133 BMEI0422 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539339.1 442877 R 224914 CDS NP_539340.1 17986706 1196134 443801..444499 1 NC_003317.1 response regulator CTRA 444499 1196134 BMEI0423 Brucella melitensis bv. 1 str. 16M response regulator CTRA NP_539340.1 443801 D 224914 CDS NP_539341.1 17986707 1196135 complement(444612..445235) 1 NC_003317.1 hypothetical protein 445235 1196135 BMEI0424 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539341.1 444612 R 224914 CDS NP_539342.1 17986708 1196136 445653..446249 1 NC_003317.1 hypothetical protein 446249 1196136 BMEI0425 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539342.1 445653 D 224914 CDS NP_539343.1 17986709 1196137 complement(447326..447754) 1 NC_003317.1 acetyltransferase 447754 1196137 BMEI0426 Brucella melitensis bv. 1 str. 16M acetyltransferase NP_539343.1 447326 R 224914 CDS NP_539344.1 17986710 1196138 complement(447957..448232) 1 NC_003317.1 hypothetical protein 448232 1196138 BMEI0427 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539344.1 447957 R 224914 CDS NP_539345.1 17986711 1196139 448537..449733 1 NC_003317.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 449733 mnmA 1196139 mnmA Brucella melitensis bv. 1 str. 16M tRNA-specific 2-thiouridylase MnmA NP_539345.1 448537 D 224914 CDS NP_539346.1 17986712 1196140 complement(449955..450785) 1 NC_003317.1 23S rRNA methyltransferase RumA 450785 1196140 BMEI0429 Brucella melitensis bv. 1 str. 16M 23S rRNA methyltransferase RumA NP_539346.1 449955 R 224914 CDS NP_539347.1 17986713 1196141 complement(450815..451162) 1 NC_003317.1 nodulation protein NOLR 451162 1196141 BMEI0430 Brucella melitensis bv. 1 str. 16M nodulation protein NOLR NP_539347.1 450815 R 224914 CDS NP_539348.1 17986714 1196142 451152..451379 1 NC_003317.1 hypothetical protein 451379 1196142 BMEI0431 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539348.1 451152 D 224914 CDS NP_539349.1 17986715 1196143 complement(451620..451868) 1 NC_003317.1 hypothetical protein 451868 1196143 BMEI0432 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539349.1 451620 R 224914 CDS NP_539350.1 17986716 1196144 452103..453161 1 NC_003317.1 periplasmic dipeptide transport protein 453161 1196144 BMEI0433 Brucella melitensis bv. 1 str. 16M periplasmic dipeptide transport protein NP_539350.1 452103 D 224914 CDS NP_539351.1 17986717 1196145 453180..453740 1 NC_003317.1 periplasmic dipeptide transport protein 453740 1196145 BMEI0434 Brucella melitensis bv. 1 str. 16M periplasmic dipeptide transport protein NP_539351.1 453180 D 224914 CDS NP_539352.1 17986718 1196146 453926..454969 1 NC_003317.1 peptide ABC transporter permease 454969 1196146 BMEI0435 Brucella melitensis bv. 1 str. 16M peptide ABC transporter permease NP_539352.1 453926 D 224914 CDS NP_539353.1 17986719 1196147 454977..455885 1 NC_003317.1 peptide ABC transporter permease 455885 1196147 BMEI0436 Brucella melitensis bv. 1 str. 16M peptide ABC transporter permease NP_539353.1 454977 D 224914 CDS NP_539354.1 17986720 1196148 455882..456739 1 NC_003317.1 peptide ABC transporter ATP-binding protein 456739 1196148 BMEI0437 Brucella melitensis bv. 1 str. 16M peptide ABC transporter ATP-binding protein NP_539354.1 455882 D 224914 CDS NP_539355.1 17986721 1196149 456736..457584 1 NC_003317.1 peptide ABC transporter ATP-binding protein 457584 1196149 BMEI0438 Brucella melitensis bv. 1 str. 16M peptide ABC transporter ATP-binding protein NP_539355.1 456736 D 224914 CDS NP_539356.1 17986722 1196150 complement(457858..458904) 1 NC_003317.1 glycine betaine/L-proline transport ATP-binding protein proV 458904 1196150 BMEI0439 Brucella melitensis bv. 1 str. 16M glycine betaine/L-proline transport ATP-binding protein proV NP_539356.1 457858 R 224914 CDS NP_539357.1 17986723 1196151 complement(459074..459910) 1 NC_003317.1 glycine betaine/L-proline transport system permease protein proW 459910 1196151 BMEI0440 Brucella melitensis bv. 1 str. 16M glycine betaine/L-proline transport system permease protein proW NP_539357.1 459074 R 224914 CDS NP_539358.1 17986724 1196152 complement(459999..460979) 1 NC_003317.1 glycine betaine/L-proline-binding protein PROX 460979 1196152 BMEI0441 Brucella melitensis bv. 1 str. 16M glycine betaine/L-proline-binding protein PROX NP_539358.1 459999 R 224914 CDS NP_539359.1 17986725 1196153 461170..461406 1 NC_003317.1 hypothetical protein 461406 1196153 BMEI0442 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539359.1 461170 D 224914 CDS NP_539360.1 17986726 1196154 461553..462599 1 NC_003317.1 hypothetical protein 462599 1196154 BMEI0443 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539360.1 461553 D 224914 CDS NP_539361.1 17986727 1196155 462605..463570 1 NC_003317.1 methyltransferase 463570 1196155 BMEI0444 Brucella melitensis bv. 1 str. 16M methyltransferase NP_539361.1 462605 D 224914 CDS NP_539362.1 17986728 1196156 complement(463565..464731) 1 NC_003317.1 oxalate/formate antiporter 464731 1196156 BMEI0445 Brucella melitensis bv. 1 str. 16M oxalate/formate antiporter NP_539362.1 463565 R 224914 CDS NP_539363.1 17986729 1196157 complement(464953..465177) 1 NC_003317.1 MarR family transcriptional regulator 465177 1196157 BMEI0446 Brucella melitensis bv. 1 str. 16M MarR family transcriptional regulator NP_539363.1 464953 R 224914 CDS NP_539364.1 17986730 1196158 complement(465504..465968) 1 NC_003317.1 leucine-responsive regulatory protein 465968 1196158 BMEI0447 Brucella melitensis bv. 1 str. 16M leucine-responsive regulatory protein NP_539364.1 465504 R 224914 CDS NP_539365.1 17986731 1196159 complement(466457..466645) 1 NC_003317.1 hypothetical protein 466645 1196159 BMEI0448 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539365.1 466457 R 224914 CDS NP_539366.1 17986732 1196160 466644..468839 1 NC_003317.1 trpE(G); catalyzes the formation of anthranilate from chorismate and glutamine; contains both component I and II; anthranilate synthase 468839 1196160 BMEI0449 Brucella melitensis bv. 1 str. 16M anthranilate synthase NP_539366.1 466644 D 224914 CDS NP_539367.1 17986733 1196161 469308..470216 1 NC_003317.1 cobalt-zinc-cadmium resistance protein CZCD 470216 1196161 BMEI0450 Brucella melitensis bv. 1 str. 16M cobalt-zinc-cadmium resistance protein CZCD NP_539367.1 469308 D 224914 CDS NP_539368.2 161511158 1196162 470581..472248 1 NC_003317.1 2-isopropylmalate synthase 472248 1196162 BMEI0451 Brucella melitensis bv. 1 str. 16M 2-isopropylmalate synthase NP_539368.2 470581 D 224914 CDS NP_539369.1 17986735 1196163 complement(472449..473360) 1 NC_003317.1 Icc family phosphohydrolase 473360 1196163 BMEI0452 Brucella melitensis bv. 1 str. 16M Icc family phosphohydrolase NP_539369.1 472449 R 224914 CDS NP_539370.1 17986736 1196164 473460..473915 1 NC_003317.1 MUTT/NUDIX family protein 473915 1196164 BMEI0453 Brucella melitensis bv. 1 str. 16M MUTT/NUDIX family protein NP_539370.1 473460 D 224914 CDS NP_539371.1 17986737 1196165 complement(473944..474603) 1 NC_003317.1 outer membrane protein W 474603 1196165 BMEI0454 Brucella melitensis bv. 1 str. 16M outer membrane protein W NP_539371.1 473944 R 224914 CDS NP_539372.1 17986738 1196166 complement(474775..475758) 1 NC_003317.1 glutathione S-transferase 475758 1196166 BMEI0455 Brucella melitensis bv. 1 str. 16M glutathione S-transferase NP_539372.1 474775 R 224914 CDS NP_539373.1 17986739 1196167 476050..476568 1 NC_003317.1 acetyltransferase 476568 1196167 BMEI0456 Brucella melitensis bv. 1 str. 16M acetyltransferase NP_539373.1 476050 D 224914 CDS NP_539374.1 17986740 1196168 complement(476448..478571) 1 NC_003317.1 hypothetical protein 478571 1196168 BMEI0457 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539374.1 476448 R 224914 CDS NP_539375.1 17986741 1196169 complement(478770..481571) 1 NC_003317.1 hypothetical protein 481571 1196169 BMEI0458 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539375.1 478770 R 224914 CDS NP_539376.1 17986742 1196170 complement(481616..482545) 1 NC_003317.1 hypothetical protein 482545 1196170 BMEI0459 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539376.1 481616 R 224914 CDS NP_539377.1 17986743 1196171 complement(482548..483555) 1 NC_003317.1 MoxR protein 483555 1196171 BMEI0460 Brucella melitensis bv. 1 str. 16M MoxR protein NP_539377.1 482548 R 224914 CDS NP_539378.1 17986744 1196172 483675..484340 1 NC_003317.1 hypothetical protein 484340 1196172 BMEI0461 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539378.1 483675 D 224914 CDS NP_539379.1 17986745 1196173 484337..484960 1 NC_003317.1 phosphohydrolase 484960 1196173 BMEI0462 Brucella melitensis bv. 1 str. 16M phosphohydrolase NP_539379.1 484337 D 224914 CDS NP_539380.1 17986746 1196174 484957..486228 1 NC_003317.1 poly(A) polymerase 486228 1196174 BMEI0463 Brucella melitensis bv. 1 str. 16M poly(A) polymerase NP_539380.1 484957 D 224914 CDS NP_539381.1 17986747 1196175 486419..486940 1 NC_003317.1 lipid A-myristate beta-hydroxylase 486940 1196175 BMEI0464 Brucella melitensis bv. 1 str. 16M lipid A-myristate beta-hydroxylase NP_539381.1 486419 D 224914 CDS NP_539382.1 17986748 1196176 486886..487173 1 NC_003317.1 aspartyl/asparaginyl beta-hydroxylase 487173 1196176 BMEI0465 Brucella melitensis bv. 1 str. 16M aspartyl/asparaginyl beta-hydroxylase NP_539382.1 486886 D 224914 CDS NP_539383.1 17986749 1196177 487246..487755 1 NC_003317.1 acetyltransferase 487755 1196177 BMEI0466 Brucella melitensis bv. 1 str. 16M acetyltransferase NP_539383.1 487246 D 224914 CDS NP_539384.1 17986750 1196178 complement(487789..488811) 1 NC_003317.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis; coproporphyrinogen III oxidase 488811 1196178 BMEI0467 Brucella melitensis bv. 1 str. 16M coproporphyrinogen III oxidase NP_539384.1 487789 R 224914 CDS NP_539385.1 17986751 1196179 488994..489254 1 NC_003317.1 hypothetical protein 489254 1196179 BMEI0468 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539385.1 488994 D 224914 CDS NP_539386.1 17986752 1196180 complement(489366..490403) 1 NC_003317.1 purine nucleoside permease 490403 1196180 BMEI0469 Brucella melitensis bv. 1 str. 16M purine nucleoside permease NP_539386.1 489366 R 224914 CDS NP_539387.1 17986753 1196181 complement(490513..491028) 1 NC_003317.1 ribosomal RNA methyltransferase 491028 1196181 BMEI0470 Brucella melitensis bv. 1 str. 16M ribosomal RNA methyltransferase NP_539387.1 490513 R 224914 CDS NP_539388.1 17986754 1196182 491125..493005 1 NC_003317.1 ABC transporter ATP-binding protein 493005 1196182 BMEI0471 Brucella melitensis bv. 1 str. 16M ABC transporter ATP-binding protein NP_539388.1 491125 D 224914 CDS NP_539389.1 17986755 1196183 493159..495027 1 NC_003317.1 ABC transporter ATP-binding protein 495027 1196183 BMEI0472 Brucella melitensis bv. 1 str. 16M ABC transporter ATP-binding protein NP_539389.1 493159 D 224914 CDS NP_539390.1 17986756 1196184 495261..495842 1 NC_003317.1 ubiquinol-cytochrome C reductase IRON-sulfur subunit 495842 1196184 BMEI0473 Brucella melitensis bv. 1 str. 16M ubiquinol-cytochrome C reductase IRON-sulfur subunit NP_539390.1 495261 D 224914 CDS NP_539391.1 17986757 1196185 495864..497162 1 NC_003317.1 cytochrome B 497162 1196185 BMEI0474 Brucella melitensis bv. 1 str. 16M cytochrome B NP_539391.1 495864 D 224914 CDS NP_539392.1 17986758 1196186 497257..498063 1 NC_003317.1 cytochrome C1 498063 1196186 BMEI0475 Brucella melitensis bv. 1 str. 16M cytochrome C1 NP_539392.1 497257 D 224914 CDS NP_539393.1 17986759 1196187 498371..498931 1 NC_003317.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 498931 1196187 BMEI0476 Brucella melitensis bv. 1 str. 16M adenine phosphoribosyltransferase NP_539393.1 498371 D 224914 CDS NP_539394.1 17986760 1196188 complement(498973..499455) 1 NC_003317.1 monoamine oxidase regulatory protein 499455 1196188 BMEI0477 Brucella melitensis bv. 1 str. 16M monoamine oxidase regulatory protein NP_539394.1 498973 R 224914 CDS NP_539395.1 17986761 1196189 complement(499452..499952) 1 NC_003317.1 (R)-specific enoyl-CoA hydratase 499952 1196189 BMEI0478 Brucella melitensis bv. 1 str. 16M (R)-specific enoyl-CoA hydratase NP_539395.1 499452 R 224914 CDS NP_539396.1 17986762 1196190 complement(500014..501117) 1 NC_003317.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 501117 1196190 BMEI0479 Brucella melitensis bv. 1 str. 16M GTP-dependent nucleic acid-binding protein EngD NP_539396.1 500014 R 224914 CDS NP_539397.1 17986763 1196191 complement(501205..501957) 1 NC_003317.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 501957 1196191 BMEI0480 Brucella melitensis bv. 1 str. 16M peptidyl-tRNA hydrolase NP_539397.1 501205 R 224914 CDS NP_539398.2 161511157 1196192 complement(501986..502609) 1 NC_003317.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 502609 1196192 BMEI0481 Brucella melitensis bv. 1 str. 16M 50S ribosomal protein L25 NP_539398.2 501986 R 224914 CDS NP_539399.1 17986765 1196193 503419..504843 1 NC_003317.1 ATP-binding protein 504843 1196193 BMEI0482 Brucella melitensis bv. 1 str. 16M ATP-binding protein NP_539399.1 503419 D 224914 CDS NP_539400.1 17986766 1196194 complement(504991..505977) 1 NC_003317.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 505977 1196194 BMEI0483 Brucella melitensis bv. 1 str. 16M ribose-phosphate pyrophosphokinase NP_539400.1 504991 R 224914 CDS NP_539401.1 17986767 1196195 complement(506262..506774) 1 NC_003317.1 hypothetical protein 506774 1196195 BMEI0484 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539401.1 506262 R 224914 CDS NP_539402.1 17986768 1196196 complement(506870..508021) 1 NC_003317.1 Xaa-Pro dipeptidase 508021 1196196 BMEI0485 Brucella melitensis bv. 1 str. 16M Xaa-Pro dipeptidase NP_539402.1 506870 R 224914 CDS NP_539403.1 17986769 1196197 complement(508134..508931) 1 NC_003317.1 hypothetical protein 508931 1196197 BMEI0486 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539403.1 508134 R 224914 CDS NP_539404.1 17986770 1196198 complement(509165..510370) 1 NC_003317.1 ATP synthase subunit beta 510370 1196198 BMEI0487 Brucella melitensis bv. 1 str. 16M ATP synthase subunit beta NP_539404.1 509165 R 224914 CDS NP_539405.1 17986771 1196199 complement(510255..511100) 1 NC_003317.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 511100 1196199 BMEI0488 Brucella melitensis bv. 1 str. 16M prolipoprotein diacylglyceryl transferase NP_539405.1 510255 R 224914 CDS NP_539406.1 17986772 1196200 511264..511605 1 NC_003317.1 hypothetical protein 511605 1196200 BMEI0489 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539406.1 511264 D 224914 CDS NP_539407.1 17986773 1196201 511974..512534 1 NC_003317.1 hypothetical protein 512534 1196201 BMEI0490 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539407.1 511974 D 224914 CDS NP_539408.1 17986774 1196202 512674..513021 1 NC_003317.1 protein secretion chaperonin CsaA 513021 1196202 BMEI0491 Brucella melitensis bv. 1 str. 16M protein secretion chaperonin CsaA NP_539408.1 512674 D 224914 CDS NP_539409.1 17986775 1196203 complement(513453..514796) 1 NC_003317.1 osmolarity sensor protein ENVZ 514796 1196203 BMEI0492 Brucella melitensis bv. 1 str. 16M osmolarity sensor protein ENVZ NP_539409.1 513453 R 224914 CDS NP_539410.1 17986776 1196204 complement(514940..515665) 1 NC_003317.1 transcriptional regulatory protein OMPR 515665 1196204 BMEI0493 Brucella melitensis bv. 1 str. 16M transcriptional regulatory protein OMPR NP_539410.1 514940 R 224914 CDS NP_539411.1 17986777 1196205 complement(515747..516286) 1 NC_003317.1 transcriptional regulatory protein PETP 516286 1196205 BMEI0494 Brucella melitensis bv. 1 str. 16M transcriptional regulatory protein PETP NP_539411.1 515747 R 224914 CDS NP_539412.1 17986778 1196206 516799..517089 1 NC_003317.1 hypothetical protein 517089 1196206 BMEI0495 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539412.1 516799 D 224914 CDS NP_539413.1 17986779 1196207 517303..517959 1 NC_003317.1 hydroxyacylglutathione hydrolase 517959 1196207 BMEI0496 Brucella melitensis bv. 1 str. 16M hydroxyacylglutathione hydrolase NP_539413.1 517303 D 224914 CDS NP_539414.1 17986780 1196208 complement(518018..518521) 1 NC_003317.1 hypothetical protein 518521 1196208 BMEI0497 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539414.1 518018 R 224914 CDS NP_539415.1 17986781 1196209 complement(518938..519189) 1 NC_003317.1 cold shock protein CSPA 519189 1196209 BMEI0498 Brucella melitensis bv. 1 str. 16M cold shock protein CSPA NP_539415.1 518938 R 224914 CDS NP_539416.1 17986782 1196210 complement(519562..519831) 1 NC_003317.1 soluble lytic murein transglycosylase 519831 1196210 BMEI0499 Brucella melitensis bv. 1 str. 16M soluble lytic murein transglycosylase NP_539416.1 519562 R 224914 CDS NP_539417.1 17986783 1196211 complement(519648..520385) 1 NC_003317.1 soluble lytic murein transglycosylase 520385 1196211 BMEI0500 Brucella melitensis bv. 1 str. 16M soluble lytic murein transglycosylase NP_539417.1 519648 R 224914 CDS NP_539418.1 17986784 1196212 complement(520583..523312) 1 NC_003317.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 523312 1196212 BMEI0501 Brucella melitensis bv. 1 str. 16M excinuclease ABC subunit B NP_539418.1 520583 R 224914 CDS NP_539419.1 17986785 1196213 complement(523356..524111) 1 NC_003317.1 hypothetical protein 524111 1196213 BMEI0502 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539419.1 523356 R 224914 CDS NP_539420.1 17986786 1196214 524324..524722 1 NC_003317.1 acyl-CoA hydrolase 524722 1196214 BMEI0503 Brucella melitensis bv. 1 str. 16M acyl-CoA hydrolase NP_539420.1 524324 D 224914 CDS NP_539421.1 17986787 1196215 complement(524855..525502) 1 NC_003317.1 extensin 525502 1196215 BMEI0504 Brucella melitensis bv. 1 str. 16M extensin NP_539421.1 524855 R 224914 CDS NP_539422.1 17986788 1196216 526071..526394 1 NC_003317.1 hypothetical protein 526394 1196216 BMEI0505 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539422.1 526071 D 224914 CDS NP_539423.1 17986789 1196217 complement(526399..527313) 1 NC_003317.1 transporter, DME family 527313 1196217 BMEI0506 Brucella melitensis bv. 1 str. 16M transporter, DME family NP_539423.1 526399 R 224914 CDS NP_539424.1 17986790 1196218 527466..528521 1 NC_003317.1 hypothetical protein 528521 1196218 BMEI0507 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539424.1 527466 D 224914 CDS NP_539425.1 17986791 1196219 528790..529263 1 NC_003317.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 529263 greA 1196219 greA Brucella melitensis bv. 1 str. 16M transcription elongation factor GreA NP_539425.1 528790 D 224914 CDS NP_539426.1 17986792 1196220 529270..530334 1 NC_003317.1 lipopolysaccharide core biosynthesis mannosyltransferase LPCC 530334 1196220 BMEI0509 Brucella melitensis bv. 1 str. 16M lipopolysaccharide core biosynthesis mannosyltransferase LPCC NP_539426.1 529270 D 224914 CDS NP_539427.1 17986793 1196221 complement(530341..530811) 1 NC_003317.1 leucine-responsive regulatory protein 530811 1196221 BMEI0510 Brucella melitensis bv. 1 str. 16M leucine-responsive regulatory protein NP_539427.1 530341 R 224914 CDS NP_539428.1 17986794 1196222 complement(531069..532469) 1 NC_003317.1 TRK system potassium uptake protein TRKH 532469 1196222 BMEI0511 Brucella melitensis bv. 1 str. 16M TRK system potassium uptake protein TRKH NP_539428.1 531069 R 224914 CDS NP_539429.1 17986795 1196223 532791..533765 1 NC_003317.1 thioredoxin reductase 533765 1196223 BMEI0512 Brucella melitensis bv. 1 str. 16M thioredoxin reductase NP_539429.1 532791 D 224914 CDS NP_539430.1 17986796 1196224 533836..534741 1 NC_003317.1 LysR family transcriptional regulator 534741 1196224 BMEI0513 Brucella melitensis bv. 1 str. 16M LysR family transcriptional regulator NP_539430.1 533836 D 224914 CDS NP_539431.1 17986797 1196225 complement(534793..534972) 1 NC_003317.1 hypothetical protein 534972 1196225 BMEI0514 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539431.1 534793 R 224914 CDS NP_539432.1 17986798 1196226 534934..535149 1 NC_003317.1 hypothetical protein 535149 1196226 BMEI0515 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539432.1 534934 D 224914 CDS NP_539433.1 17986799 1196227 complement(535210..536475) 1 NC_003317.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; aspartate aminotransferase 536475 1196227 BMEI0516 Brucella melitensis bv. 1 str. 16M aspartate aminotransferase NP_539433.1 535210 R 224914 CDS NP_539434.1 17986800 1196228 536584..537273 1 NC_003317.1 glutathione S-transferase 537273 1196228 BMEI0517 Brucella melitensis bv. 1 str. 16M glutathione S-transferase NP_539434.1 536584 D 224914 CDS NP_539435.1 17986801 1196229 complement(537402..537707) 1 NC_003317.1 cold shock protein CSPA 537707 1196229 BMEI0518 Brucella melitensis bv. 1 str. 16M cold shock protein CSPA NP_539435.1 537402 R 224914 CDS NP_539436.1 17986802 1196230 complement(537804..538196) 1 NC_003317.1 phosphohydrolase 538196 1196230 BMEI0519 Brucella melitensis bv. 1 str. 16M phosphohydrolase NP_539436.1 537804 R 224914 CDS NP_539437.1 17986803 1196231 538455..540320 1 NC_003317.1 ABC transporter ATP-binding protein 540320 1196231 BMEI0520 Brucella melitensis bv. 1 str. 16M ABC transporter ATP-binding protein NP_539437.1 538455 D 224914 CDS NP_539438.1 17986804 1196232 complement(540378..540779) 1 NC_003317.1 hypothetical protein 540779 1196232 BMEI0521 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539438.1 540378 R 224914 CDS NP_539439.1 17986805 1196233 complement(541037..544525) 1 NC_003317.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 544525 carB 1196233 carB Brucella melitensis bv. 1 str. 16M carbamoyl phosphate synthase large subunit NP_539439.1 541037 R 224914 CDS NP_539440.1 17986806 1196234 complement(545020..545523) 1 NC_003317.1 hypothetical protein 545523 1196234 BMEI0523 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539440.1 545020 R 224914 CDS NP_539441.1 17986807 1196235 545738..546163 1 NC_003317.1 hypothetical protein 546163 1196235 BMEI0524 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539441.1 545738 D 224914 CDS NP_539442.1 17986808 1196236 546280..547206 1 NC_003317.1 zinc protease 547206 1196236 BMEI0525 Brucella melitensis bv. 1 str. 16M zinc protease NP_539442.1 546280 D 224914 CDS NP_539443.2 161511156 1196237 complement(547378..548601) 1 NC_003317.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 548601 1196237 BMEI0526 Brucella melitensis bv. 1 str. 16M carbamoyl phosphate synthase small subunit NP_539443.2 547378 R 224914 CDS NP_539444.1 17986810 1196238 548924..549433 1 NC_003317.1 hypothetical protein 549433 1196238 BMEI0527 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539444.1 548924 D 224914 CDS NP_539445.1 17986811 1196239 complement(549500..550540) 1 NC_003317.1 sodium-dependent phosphate transport protein 550540 1196239 BMEI0528 Brucella melitensis bv. 1 str. 16M sodium-dependent phosphate transport protein NP_539445.1 549500 R 224914 CDS NP_539446.1 17986812 1196240 complement(550547..551155) 1 NC_003317.1 sodium-dependent phosphate transport protein 551155 1196240 BMEI0529 Brucella melitensis bv. 1 str. 16M sodium-dependent phosphate transport protein NP_539446.1 550547 R 224914 CDS NP_539447.1 17986813 1196241 551468..553513 1 NC_003317.1 synthesizes RNA primers at the replication forks; DNA primase 553513 dnaG 1196241 dnaG Brucella melitensis bv. 1 str. 16M DNA primase NP_539447.1 551468 D 224914 CDS NP_539448.1 17986814 1196242 complement(553592..553822) 1 NC_003317.1 hypothetical protein 553822 1196242 BMEI0531 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539448.1 553592 R 224914 CDS NP_539449.1 17986815 1196243 553985..556003 1 NC_003317.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria; RNA polymerase sigma factor RpoD 556003 1196243 BMEI0532 Brucella melitensis bv. 1 str. 16M RNA polymerase sigma factor RpoD NP_539449.1 553985 D 224914 CDS NP_539450.1 17986816 1196244 556027..556317 1 NC_003317.1 hypothetical protein 556317 1196244 BMEI0533 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539450.1 556027 D 224914 CDS NP_539451.1 17986817 1196245 556455..556967 1 NC_003317.1 hypothetical protein 556967 1196245 BMEI0534 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539451.1 556455 D 224914 CDS NP_539452.1 17986818 1196246 557211..557555 1 NC_003317.1 hypothetical protein 557555 1196246 BMEI0535 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539452.1 557211 D 224914 CDS NP_539453.1 17986819 1196247 complement(557729..558481) 1 NC_003317.1 immunogenic protein 558481 1196247 BMEI0536 Brucella melitensis bv. 1 str. 16M immunogenic protein NP_539453.1 557729 R 224914 CDS NP_539454.1 17986820 1196248 complement(558899..559249) 1 NC_003317.1 integrase/recombinase 559249 1196248 BMEI0537 Brucella melitensis bv. 1 str. 16M integrase/recombinase NP_539454.1 558899 R 224914 CDS NP_539455.1 17986821 1196249 complement(559458..559817) 1 NC_003317.1 hypothetical protein 559817 1196249 BMEI0538 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539455.1 559458 R 224914 CDS NP_539456.1 17986822 1196250 559812..560201 1 NC_003317.1 hypothetical protein 560201 1196250 BMEI0539 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539456.1 559812 D 224914 CDS NP_539457.1 17986823 1196251 complement(560362..560715) 1 NC_003317.1 hypothetical protein 560715 1196251 BMEI0540 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539457.1 560362 R 224914 CDS NP_539458.1 17986824 1196252 560863..561069 1 NC_003317.1 hypothetical protein 561069 1196252 BMEI0541 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539458.1 560863 D 224914 CDS NP_539459.1 17986825 1196253 complement(561915..562718) 1 NC_003317.1 hypothetical protein 562718 1196253 BMEI0542 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539459.1 561915 R 224914 CDS NP_539460.1 17986826 1196254 562994..564097 1 NC_003317.1 choloylglycine hydrolase 564097 1196254 BMEI0543 Brucella melitensis bv. 1 str. 16M choloylglycine hydrolase NP_539460.1 562994 D 224914 CDS NP_539461.1 17986827 1196255 complement(564295..564561) 1 NC_003317.1 hypothetical protein 564561 1196255 BMEI0544 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539461.1 564295 R 224914 CDS NP_539462.1 17986828 1196256 564908..565969 1 NC_003317.1 hypothetical protein 565969 1196256 BMEI0545 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539462.1 564908 D 224914 CDS NP_539463.1 17986829 1196257 complement(565966..566721) 1 NC_003317.1 pyrazinamidase / nicotinamidase 566721 1196257 BMEI0546 Brucella melitensis bv. 1 str. 16M pyrazinamidase / nicotinamidase NP_539463.1 565966 R 224914 CDS NP_539464.1 17986830 1196258 566733..566954 1 NC_003317.1 PhnA protein 566954 1196258 BMEI0547 Brucella melitensis bv. 1 str. 16M PhnA protein NP_539464.1 566733 D 224914 CDS NP_539465.1 17986831 1196259 complement(566957..568093) 1 NC_003317.1 flavohemoprotein 568093 1196259 BMEI0548 Brucella melitensis bv. 1 str. 16M flavohemoprotein NP_539465.1 566957 R 224914 CDS NP_539466.1 17986832 1196260 complement(568109..569356) 1 NC_003317.1 benzoate 1,2-dioxygenase subunit alpha 569356 1196260 BMEI0549 Brucella melitensis bv. 1 str. 16M benzoate 1,2-dioxygenase subunit alpha NP_539466.1 568109 R 224914 CDS NP_539467.1 17986833 1196261 569793..570392 1 NC_003317.1 hypothetical protein 570392 1196261 BMEI0550 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539467.1 569793 D 224914 CDS NP_539468.1 17986834 1196262 complement(570486..570956) 1 NC_003317.1 hypothetical protein 570956 1196262 BMEI0551 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539468.1 570486 R 224914 CDS NP_539469.1 17986835 1196263 complement(571189..572133) 1 NC_003317.1 lysophospholipase L2 572133 1196263 BMEI0552 Brucella melitensis bv. 1 str. 16M lysophospholipase L2 NP_539469.1 571189 R 224914 CDS NP_539470.1 17986836 1196264 572524..574278 1 NC_003317.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; ABC transporter ATP-binding protein 574278 1196264 BMEI0553 Brucella melitensis bv. 1 str. 16M ABC transporter ATP-binding protein NP_539470.1 572524 D 224914 CDS NP_539471.1 17986837 1196265 574452..575117 1 NC_003317.1 catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate; trans-aconitate 2-methyltransferase 575117 1196265 BMEI0554 Brucella melitensis bv. 1 str. 16M trans-aconitate 2-methyltransferase NP_539471.1 574452 D 224914 CDS NP_539472.1 17986838 1196266 complement(575291..575545) 1 NC_003317.1 hypothetical protein 575545 1196266 BMEI0555 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539472.1 575291 R 224914 CDS NP_539473.1 17986839 1196267 575505..576878 1 NC_003317.1 alpha-ketoglutarate permease 576878 1196267 BMEI0556 Brucella melitensis bv. 1 str. 16M alpha-ketoglutarate permease NP_539473.1 575505 D 224914 CDS NP_539474.1 17986840 1196268 complement(576933..577256) 1 NC_003317.1 hypothetical protein 577256 1196268 BMEI0557 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539474.1 576933 R 224914 CDS NP_539475.1 17986841 1196269 577385..578401 1 NC_003317.1 ArsR family transcriptional regulator 578401 1196269 BMEI0558 Brucella melitensis bv. 1 str. 16M ArsR family transcriptional regulator NP_539475.1 577385 D 224914 CDS NP_539476.1 17986842 1196270 578534..579358 1 NC_003317.1 5,10-methylenetetrahydrofolate reductase 579358 1196270 BMEI0559 Brucella melitensis bv. 1 str. 16M 5,10-methylenetetrahydrofolate reductase NP_539476.1 578534 D 224914 CDS NP_539477.1 17986843 1196271 complement(579793..580728) 1 NC_003317.1 transporter 580728 1196271 BMEI0560 Brucella melitensis bv. 1 str. 16M transporter NP_539477.1 579793 R 224914 CDS NP_539478.1 17986844 1196272 complement(580790..581986) 1 NC_003317.1 membrane-bound lytic murein transglycosylase B 581986 1196272 BMEI0561 Brucella melitensis bv. 1 str. 16M membrane-bound lytic murein transglycosylase B NP_539478.1 580790 R 224914 CDS NP_539479.1 17986845 1196273 complement(582144..582977) 1 NC_003317.1 lysozyme M1 582977 1196273 BMEI0562 Brucella melitensis bv. 1 str. 16M lysozyme M1 NP_539479.1 582144 R 224914 CDS NP_539480.1 17986846 1196274 583332..583685 1 NC_003317.1 hypothetical protein 583685 1196274 BMEI0563 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539480.1 583332 D 224914 CDS NP_539481.1 17986847 1196275 583804..584514 1 NC_003317.1 DNAJ-like protein DJLA 584514 1196275 BMEI0564 Brucella melitensis bv. 1 str. 16M DNAJ-like protein DJLA NP_539481.1 583804 D 224914 CDS NP_539482.1 17986848 1196276 584511..585317 1 NC_003317.1 anhydro-N-acetylmuramyl-tripeptide amidase 585317 1196276 BMEI0565 Brucella melitensis bv. 1 str. 16M anhydro-N-acetylmuramyl-tripeptide amidase NP_539482.1 584511 D 224914 CDS NP_539483.1 17986849 1196277 585889..586302 1 NC_003317.1 soluble lytic murein transglycosylase 586302 1196277 BMEI0566 Brucella melitensis bv. 1 str. 16M soluble lytic murein transglycosylase NP_539483.1 585889 D 224914 CDS NP_539484.1 17986850 1196278 complement(586299..586811) 1 NC_003317.1 hypothetical protein 586811 1196278 BMEI0567 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539484.1 586299 R 224914 CDS NP_539485.1 17986851 1196279 complement(586487..586759) 1 NC_003317.1 hypothetical protein 586759 1196279 BMEI0568 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539485.1 586487 R 224914 CDS NP_539486.1 17986852 1196280 complement(587004..588374) 1 NC_003317.1 manganese transport protein MntH 588374 1196280 BMEI0569 Brucella melitensis bv. 1 str. 16M manganese transport protein MntH NP_539486.1 587004 R 224914 CDS NP_539487.1 17986853 1196281 complement(588601..588870) 1 NC_003317.1 hypothetical protein 588870 1196281 BMEI0570 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539487.1 588601 R 224914 CDS NP_539488.1 17986854 1196282 588848..589888 1 NC_003317.1 S-adenosyl-methyltransferase MraW 589888 mraW 1196282 mraW Brucella melitensis bv. 1 str. 16M S-adenosyl-methyltransferase MraW NP_539488.1 588848 D 224914 CDS NP_539489.1 17986855 1196283 589893..590306 1 NC_003317.1 hypothetical protein 590306 1196283 BMEI0572 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539489.1 589893 D 224914 CDS NP_539490.1 17986856 1196284 590297..592120 1 NC_003317.1 penicillin-binding protein 2 592120 1196284 BMEI0573 Brucella melitensis bv. 1 str. 16M penicillin-binding protein 2 NP_539490.1 590297 D 224914 CDS NP_539491.1 17986857 1196285 592148..593647 1 NC_003317.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 593647 murE 1196285 murE Brucella melitensis bv. 1 str. 16M UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase NP_539491.1 592148 D 224914 CDS NP_539492.1 17986858 1196286 593644..595089 1 NC_003317.1 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D - alanyl ligase 595089 1196286 BMEI0575 Brucella melitensis bv. 1 str. 16M UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D - alanyl ligase NP_539492.1 593644 D 224914 CDS NP_539493.1 17986859 1196287 595116..596198 1 NC_003317.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 596198 mraY 1196287 mraY Brucella melitensis bv. 1 str. 16M phospho-N-acetylmuramoyl-pentapeptide- transferase NP_539493.1 595116 D 224914 CDS NP_539494.1 17986860 1196288 596211..597614 1 NC_003317.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 597614 murD 1196288 murD Brucella melitensis bv. 1 str. 16M UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase NP_539494.1 596211 D 224914 CDS NP_539495.1 17986861 1196289 597614..598771 1 NC_003317.1 cell division protein FTSW 598771 1196289 BMEI0578 Brucella melitensis bv. 1 str. 16M cell division protein FTSW NP_539495.1 597614 D 224914 CDS NP_539496.1 17986862 1196290 598995..600137 1 NC_003317.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase 600137 murG 1196290 murG Brucella melitensis bv. 1 str. 16M undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase NP_539496.1 598995 D 224914 CDS NP_539497.1 17986863 1196291 600134..601549 1 NC_003317.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 601549 murC 1196291 murC Brucella melitensis bv. 1 str. 16M UDP-N-acetylmuramate--L-alanine ligase NP_539497.1 600134 D 224914 CDS NP_539498.1 17986864 1196292 601603..602517 1 NC_003317.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 602517 murB 1196292 murB Brucella melitensis bv. 1 str. 16M UDP-N-acetylenolpyruvoylglucosamine reductase NP_539498.1 601603 D 224914 CDS NP_539499.1 17986865 1196293 602739..603686 1 NC_003317.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanine--D-alanine ligase 603686 ddl 1196293 ddl Brucella melitensis bv. 1 str. 16M D-alanine--D-alanine ligase NP_539499.1 602739 D 224914 CDS NP_539500.1 17986866 1196294 603653..604609 1 NC_003317.1 cell division protein FtsQ 604609 1196294 BMEI0583 Brucella melitensis bv. 1 str. 16M cell division protein FtsQ NP_539500.1 603653 D 224914 CDS NP_539501.1 17986867 1196295 604606..605928 1 NC_003317.1 cell division protein FTSA 605928 1196295 BMEI0584 Brucella melitensis bv. 1 str. 16M cell division protein FTSA NP_539501.1 604606 D 224914 CDS NP_539502.1 17986868 1196296 606025..607641 1 NC_003317.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 607641 1196296 BMEI0585 Brucella melitensis bv. 1 str. 16M cell division protein FtsZ NP_539502.1 606025 D 224914 CDS NP_539503.1 17986869 1196297 608267..609127 1 NC_003317.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 609127 lpxC 1196297 lpxC Brucella melitensis bv. 1 str. 16M UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase NP_539503.1 608267 D 224914 CDS NP_539504.1 17986870 1196298 609468..610397 1 NC_003317.1 COML, competence lipoprotein 610397 1196298 BMEI0587 Brucella melitensis bv. 1 str. 16M COML, competence lipoprotein NP_539504.1 609468 D 224914 CDS NP_539505.1 17986871 1196299 610410..612089 1 NC_003317.1 DNA repair protein RECN 612089 1196299 BMEI0588 Brucella melitensis bv. 1 str. 16M DNA repair protein RECN NP_539505.1 610410 D 224914 CDS NP_539506.1 17986872 1196300 612275..614434 1 NC_003317.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 614434 ligA 1196300 ligA Brucella melitensis bv. 1 str. 16M NAD-dependent DNA ligase LigA NP_539506.1 612275 D 224914 CDS NP_539507.1 17986873 1196301 614434..615138 1 NC_003317.1 hypothetical protein 615138 1196301 BMEI0590 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539507.1 614434 D 224914 CDS NP_539508.1 17986874 1196302 complement(615139..616965) 1 NC_003317.1 XAA-Pro aminopeptidase 616965 1196302 BMEI0591 Brucella melitensis bv. 1 str. 16M XAA-Pro aminopeptidase NP_539508.1 615139 R 224914 CDS NP_539509.1 17986875 1196303 complement(617042..617899) 1 NC_003317.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; 50S ribosomal protein L11 methyltransferase 617899 prmA 1196303 prmA Brucella melitensis bv. 1 str. 16M 50S ribosomal protein L11 methyltransferase NP_539509.1 617042 R 224914 CDS NP_539510.1 17986876 1196304 complement(617937..618527) 1 NC_003317.1 SCO2 protein 618527 1196304 BMEI0593 Brucella melitensis bv. 1 str. 16M SCO2 protein NP_539510.1 617937 R 224914 CDS NP_539511.1 17986877 1196305 618639..619325 1 NC_003317.1 chloramphenicol acetyltransferase 619325 1196305 BMEI0594 Brucella melitensis bv. 1 str. 16M chloramphenicol acetyltransferase NP_539511.1 618639 D 224914 CDS NP_539512.1 17986878 1196306 619288..619887 1 NC_003317.1 CreA family protein 619887 1196306 BMEI0595 Brucella melitensis bv. 1 str. 16M CreA family protein NP_539512.1 619288 D 224914 CDS NP_539513.1 17986879 1196307 complement(619961..622444) 1 NC_003317.1 DNA helicase II 622444 1196307 BMEI0596 Brucella melitensis bv. 1 str. 16M DNA helicase II NP_539513.1 619961 R 224914 CDS NP_539514.1 17986880 1196308 complement(622596..623648) 1 NC_003317.1 serine/threonine protein kinase 623648 1196308 BMEI0597 Brucella melitensis bv. 1 str. 16M serine/threonine protein kinase NP_539514.1 622596 R 224914 CDS NP_539515.1 17986881 1196309 623792..624301 1 NC_003317.1 hypothetical protein 624301 1196309 BMEI0598 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539515.1 623792 D 224914 CDS NP_539516.1 17986882 1196310 624326..625732 1 NC_003317.1 D-lactate dehydrogenase 625732 1196310 BMEI0599 Brucella melitensis bv. 1 str. 16M D-lactate dehydrogenase NP_539516.1 624326 D 224914 CDS NP_539517.1 17986883 1196311 625987..629667 1 NC_003317.1 hypothetical protein 629667 1196311 BMEI0600 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539517.1 625987 D 224914 CDS NP_539518.1 17986884 1196312 complement(629695..629946) 1 NC_003317.1 hypothetical protein 629946 1196312 BMEI0601 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539518.1 629695 R 224914 CDS NP_539519.1 17986885 1196313 complement(629943..630143) 1 NC_003317.1 hypothetical protein 630143 1196313 BMEI0602 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539519.1 629943 R 224914 CDS NP_539520.1 17986886 1196314 complement(630524..631093) 1 NC_003317.1 hypothetical protein 631093 1196314 BMEI0603 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539520.1 630524 R 224914 CDS NP_539521.1 17986887 1196315 complement(631174..631899) 1 NC_003317.1 TetR family transcriptional regulator 631899 1196315 BMEI0604 Brucella melitensis bv. 1 str. 16M TetR family transcriptional regulator NP_539521.1 631174 R 224914 CDS NP_539522.1 17986888 1196316 632194..633465 1 NC_003317.1 bicyclomycin resistance protein 633465 1196316 BMEI0605 Brucella melitensis bv. 1 str. 16M bicyclomycin resistance protein NP_539522.1 632194 D 224914 CDS NP_539523.1 17986889 1196317 633110..633406 1 NC_003317.1 bicyclomycin resistance protein 633406 1196317 BMEI0606 Brucella melitensis bv. 1 str. 16M bicyclomycin resistance protein NP_539523.1 633110 D 224914 CDS NP_539524.1 17986890 1196318 633952..634290 1 NC_003317.1 hypothetical protein 634290 1196318 BMEI0607 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539524.1 633952 D 224914 CDS NP_539525.1 17986891 1196319 634391..635185 1 NC_003317.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 635185 thyA 1196319 thyA Brucella melitensis bv. 1 str. 16M thymidylate synthase NP_539525.1 634391 D 224914 CDS NP_539526.1 17986892 1196320 635188..635706 1 NC_003317.1 dihydrofolate reductase 635706 1196320 BMEI0609 Brucella melitensis bv. 1 str. 16M dihydrofolate reductase NP_539526.1 635188 D 224914 CDS NP_539527.1 17986893 1196321 635831..636985 1 NC_003317.1 HFLK protein 636985 1196321 BMEI0610 Brucella melitensis bv. 1 str. 16M HFLK protein NP_539527.1 635831 D 224914 CDS NP_539528.1 17986894 1196322 636985..637887 1 NC_003317.1 HFLC protein 637887 1196322 BMEI0611 Brucella melitensis bv. 1 str. 16M HFLC protein NP_539528.1 636985 D 224914 CDS NP_539529.1 17986895 1196323 637907..638092 1 NC_003317.1 hypothetical protein 638092 1196323 BMEI0612 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539529.1 637907 D 224914 CDS NP_539530.1 17986896 1196324 638316..639890 1 NC_003317.1 protease Do 639890 1196324 BMEI0613 Brucella melitensis bv. 1 str. 16M protease Do NP_539530.1 638316 D 224914 CDS NP_539531.2 161511155 1196325 640020..641201 1 NC_003317.1 NAD(FAD)-utilizing dehydrogenase 641201 1196325 BMEI0614 Brucella melitensis bv. 1 str. 16M NAD(FAD)-utilizing dehydrogenase NP_539531.2 640020 D 224914 CDS NP_539532.1 17986898 1196326 complement(641242..642150) 1 NC_003317.1 phosphoserine phosphatase 642150 1196326 BMEI0615 Brucella melitensis bv. 1 str. 16M phosphoserine phosphatase NP_539532.1 641242 R 224914 CDS NP_539533.1 17986899 1196327 642159..643091 1 NC_003317.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 643091 miaA 1196327 miaA Brucella melitensis bv. 1 str. 16M tRNA delta(2)-isopentenylpyrophosphate transferase NP_539533.1 642159 D 224914 CDS NP_539534.1 17986900 1196328 643338..645161 1 NC_003317.1 catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive; acetolactate synthase 3 catalytic subunit 645161 1196328 BMEI0617 Brucella melitensis bv. 1 str. 16M acetolactate synthase 3 catalytic subunit NP_539534.1 643338 D 224914 CDS NP_539535.1 17986901 1196329 645180..645752 1 NC_003317.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 645752 ilvH 1196329 ilvH Brucella melitensis bv. 1 str. 16M acetolactate synthase 3 regulatory subunit NP_539535.1 645180 D 224914 CDS NP_539536.1 17986902 1196330 645936..647057 1 NC_003317.1 exodeoxyribonuclease V subunit alpha 647057 1196330 BMEI0619 Brucella melitensis bv. 1 str. 16M exodeoxyribonuclease V subunit alpha NP_539536.1 645936 D 224914 CDS NP_539537.1 17986903 1196331 complement(647058..647456) 1 NC_003317.1 hypothetical protein 647456 1196331 BMEI0620 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539537.1 647058 R 224914 CDS NP_539538.1 17986904 1196332 647756..648496 1 NC_003317.1 involved in the de novo synthesis of pyridoxine (Vitamin B6); pyridoxine 5'-phosphate synthase 648496 1196332 BMEI0621 Brucella melitensis bv. 1 str. 16M pyridoxine 5'-phosphate synthase NP_539538.1 647756 D 224914 CDS NP_539539.1 17986905 1196333 648866..650821 1 NC_003317.1 KUP system potassium uptake protein 650821 1196333 BMEI0622 Brucella melitensis bv. 1 str. 16M KUP system potassium uptake protein NP_539539.1 648866 D 224914 CDS NP_539540.1 17986906 1196334 651052..651672 1 NC_003317.1 TetR family transcriptional regulator 651672 1196334 BMEI0623 Brucella melitensis bv. 1 str. 16M TetR family transcriptional regulator NP_539540.1 651052 D 224914 CDS NP_539541.1 17986907 1196335 651728..652747 1 NC_003317.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 652747 1196335 BMEI0624 Brucella melitensis bv. 1 str. 16M ketol-acid reductoisomerase NP_539541.1 651728 D 224914 CDS NP_539542.1 17986908 1196336 652769..653050 1 NC_003317.1 hypothetical protein 653050 1196336 BMEI0625 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539542.1 652769 D 224914 CDS NP_539543.1 17986909 1196337 653168..654415 1 NC_003317.1 GntR family transcriptional regulator 654415 1196337 BMEI0626 Brucella melitensis bv. 1 str. 16M GntR family transcriptional regulator NP_539543.1 653168 D 224914 CDS NP_539544.1 17986910 1196338 complement(654461..654862) 1 NC_003317.1 hypothetical protein 654862 1196338 BMEI0627 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539544.1 654461 R 224914 CDS NP_539545.1 17986911 1196339 655149..656162 1 NC_003317.1 hypothetical protein 656162 1196339 BMEI0628 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539545.1 655149 D 224914 CDS NP_539546.1 17986912 1196340 656228..656914 1 NC_003317.1 hypothetical protein 656914 1196340 BMEI0629 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539546.1 656228 D 224914 CDS NP_539547.1 17986913 1196341 657019..657945 1 NC_003317.1 phenazine biosynthesis protein PHZF 657945 1196341 BMEI0630 Brucella melitensis bv. 1 str. 16M phenazine biosynthesis protein PHZF NP_539547.1 657019 D 224914 CDS NP_539548.1 17986914 1196342 658097..658531 1 NC_003317.1 hypothetical protein 658531 1196342 BMEI0631 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539548.1 658097 D 224914 CDS NP_539549.1 17986915 1196343 complement(658659..659603) 1 NC_003317.1 hypothetical protein 659603 1196343 BMEI0632 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539549.1 658659 R 224914 CDS NP_539550.2 161511154 1196344 659953..660342 1 NC_003317.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 660342 ccrB 1196344 ccrB Brucella melitensis bv. 1 str. 16M camphor resistance protein CrcB NP_539550.2 659953 D 224914 CDS NP_539551.1 17986917 1196345 660355..661167 1 NC_003317.1 hypothetical protein 661167 1196345 BMEI0634 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539551.1 660355 D 224914 CDS NP_539552.1 17986918 1196346 complement(661188..661565) 1 NC_003317.1 cobalt ABC transporter ATP-binding protein 661565 1196346 BMEI0635 Brucella melitensis bv. 1 str. 16M cobalt ABC transporter ATP-binding protein NP_539552.1 661188 R 224914 CDS NP_539553.1 17986919 1196347 complement(661575..661907) 1 NC_003317.1 cobalt ABC transporter ATP-binding protein 661907 1196347 BMEI0636 Brucella melitensis bv. 1 str. 16M cobalt ABC transporter ATP-binding protein NP_539553.1 661575 R 224914 CDS NP_539554.1 17986920 1196348 complement(661904..662668) 1 NC_003317.1 cobalt ABC transporter permease 662668 1196348 BMEI0637 Brucella melitensis bv. 1 str. 16M cobalt ABC transporter permease NP_539554.1 661904 R 224914 CDS NP_539555.1 17986921 1196349 complement(662665..663234) 1 NC_003317.1 hypothetical protein 663234 1196349 BMEI0638 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539555.1 662665 R 224914 CDS NP_539556.1 17986922 1196350 complement(663288..663473) 1 NC_003317.1 cobalamin biosynthesis protein CbiM protein 663473 1196350 BMEI0639 Brucella melitensis bv. 1 str. 16M cobalamin biosynthesis protein CbiM protein NP_539556.1 663288 R 224914 CDS NP_539557.1 17986923 1196351 complement(663388..663924) 1 NC_003317.1 cobalamin biosynthesis protein CbiM protein 663924 1196351 BMEI0640 Brucella melitensis bv. 1 str. 16M cobalamin biosynthesis protein CbiM protein NP_539557.1 663388 R 224914 CDS NP_539558.1 17986924 1196352 complement(663944..664702) 1 NC_003317.1 hypothetical protein 664702 1196352 BMEI0641 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539558.1 663944 R 224914 CDS NP_539559.1 17986925 1196353 complement(664729..665778) 1 NC_003317.1 urea transporter 665778 1196353 BMEI0642 Brucella melitensis bv. 1 str. 16M urea transporter NP_539559.1 664729 R 224914 CDS NP_539560.1 17986926 1196354 complement(665788..666696) 1 NC_003317.1 urease accessory protein URED 666696 1196354 BMEI0643 Brucella melitensis bv. 1 str. 16M urease accessory protein URED NP_539560.1 665788 R 224914 CDS NP_539561.1 17986927 1196355 complement(666696..667334) 1 NC_003317.1 urease accessory protein UREG 667334 1196355 BMEI0644 Brucella melitensis bv. 1 str. 16M urease accessory protein UREG NP_539561.1 666696 R 224914 CDS NP_539562.1 17986928 1196356 complement(667350..668075) 1 NC_003317.1 urease accessory protein UREF 668075 1196356 BMEI0645 Brucella melitensis bv. 1 str. 16M urease accessory protein UREF NP_539562.1 667350 R 224914 CDS NP_539563.1 17986929 1196357 complement(668053..668658) 1 NC_003317.1 involved in the assembly of the urease metallocenter; possible nickel donor; urease accessory protein UreE 668658 ureE 1196357 ureE Brucella melitensis bv. 1 str. 16M urease accessory protein UreE NP_539563.1 668053 R 224914 CDS NP_539564.1 17986930 1196358 complement(668706..670427) 1 NC_003317.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits; urease subunit alpha 670427 ureC 1196358 ureC Brucella melitensis bv. 1 str. 16M urease subunit alpha NP_539564.1 668706 R 224914 CDS NP_539565.1 17986931 1196359 complement(670467..670946) 1 NC_003317.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori and Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta); in Brucella suis the urease encoded by this operon (one of two urease-encoding operons found in its genome) does not seem to be involved with urease activity, optimum growth, resistance to low-pH killing in-vitro and persistence in-vivo; urease subunit beta 670946 ureB 1196359 ureB Brucella melitensis bv. 1 str. 16M urease subunit beta NP_539565.1 670467 R 224914 CDS NP_539566.1 17986932 1196360 complement(670995..671297) 1 NC_003317.1 UreA, with UreB and UreC, catalyzes the hydrolysis of urea to ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter; urease subunit gamma 671297 ureA 1196360 ureA Brucella melitensis bv. 1 str. 16M urease subunit gamma NP_539566.1 670995 R 224914 CDS NP_539567.1 17986933 1196361 complement(671392..671772) 1 NC_003317.1 hypothetical protein 671772 1196361 BMEI0650 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539567.1 671392 R 224914 CDS NP_539568.1 17986934 1196362 672139..673407 1 NC_003317.1 hypothetical protein 673407 1196362 BMEI0651 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539568.1 672139 D 224914 CDS NP_539569.1 17986935 1196363 673480..673716 1 NC_003317.1 hypothetical protein 673716 1196363 BMEI0652 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539569.1 673480 D 224914 CDS NP_539570.1 17986936 1196364 674025..675020 1 NC_003317.1 periplasmic protein of efflux system 675020 1196364 BMEI0653 Brucella melitensis bv. 1 str. 16M periplasmic protein of efflux system NP_539570.1 674025 D 224914 CDS NP_539571.1 17986937 1196365 675249..677012 1 NC_003317.1 ABC transporter ATP-binding protein 677012 1196365 BMEI0654 Brucella melitensis bv. 1 str. 16M ABC transporter ATP-binding protein NP_539571.1 675249 D 224914 CDS NP_539572.1 17986938 1196366 676912..677787 1 NC_003317.1 ABC transporter ATP-binding protein 677787 1196366 BMEI0655 Brucella melitensis bv. 1 str. 16M ABC transporter ATP-binding protein NP_539572.1 676912 D 224914 CDS NP_539573.1 17986939 1196367 677789..678901 1 NC_003317.1 daunorubicin resistance transmembrane protein 678901 1196367 BMEI0656 Brucella melitensis bv. 1 str. 16M daunorubicin resistance transmembrane protein NP_539573.1 677789 D 224914 CDS NP_539574.1 17986940 1196368 679458..681257 1 NC_003317.1 metal chelate outer membrane receptor 681257 1196368 BMEI0657 Brucella melitensis bv. 1 str. 16M metal chelate outer membrane receptor NP_539574.1 679458 D 224914 CDS NP_539575.1 17986941 1196369 681271..682110 1 NC_003317.1 metal chelate periplasmic binding protein 682110 1196369 BMEI0658 Brucella melitensis bv. 1 str. 16M metal chelate periplasmic binding protein NP_539575.1 681271 D 224914 CDS NP_539576.1 17986942 1196370 682088..683104 1 NC_003317.1 metal chelate transport system permease protein 683104 1196370 BMEI0659 Brucella melitensis bv. 1 str. 16M metal chelate transport system permease protein NP_539576.1 682088 D 224914 CDS NP_539577.1 17986943 1196371 682837..683877 1 NC_003317.1 metal chelate transport ATP-binding protein 683877 1196371 BMEI0660 Brucella melitensis bv. 1 str. 16M metal chelate transport ATP-binding protein NP_539577.1 682837 D 224914 CDS NP_539578.1 17986944 1196372 complement(683874..684995) 1 NC_003317.1 myo-inositol 2-dehydrogenase 684995 1196372 BMEI0661 Brucella melitensis bv. 1 str. 16M myo-inositol 2-dehydrogenase NP_539578.1 683874 R 224914 CDS NP_539579.1 17986945 1196373 685407..685784 1 NC_003317.1 D-ribose-binding periplasmic protein precursor 685784 1196373 BMEI0662 Brucella melitensis bv. 1 str. 16M D-ribose-binding periplasmic protein precursor NP_539579.1 685407 D 224914 CDS NP_539580.1 17986946 1196374 685766..686278 1 NC_003317.1 D-ribose-binding periplasmic protein precursor 686278 1196374 BMEI0663 Brucella melitensis bv. 1 str. 16M D-ribose-binding periplasmic protein precursor NP_539580.1 685766 D 224914 CDS NP_539581.1 17986947 1196375 686529..687692 1 NC_003317.1 sugar transport system permease 687692 1196375 BMEI0664 Brucella melitensis bv. 1 str. 16M sugar transport system permease NP_539581.1 686529 D 224914 CDS NP_539582.1 17986948 1196376 687706..688485 1 NC_003317.1 sugar transport ATP-binding protein 688485 1196376 BMEI0665 Brucella melitensis bv. 1 str. 16M sugar transport ATP-binding protein NP_539582.1 687706 D 224914 CDS NP_539583.1 17986949 1196377 688500..689309 1 NC_003317.1 short chain dehydrogenase 689309 1196377 BMEI0666 Brucella melitensis bv. 1 str. 16M short chain dehydrogenase NP_539583.1 688500 D 224914 CDS NP_539584.1 17986950 1196378 689403..689825 1 NC_003317.1 fucose operon FUCU protein 689825 1196378 BMEI0667 Brucella melitensis bv. 1 str. 16M fucose operon FUCU protein NP_539584.1 689403 D 224914 CDS NP_539585.1 17986951 1196379 complement(689959..690513) 1 NC_003317.1 calcium binding protein 690513 1196379 BMEI0668 Brucella melitensis bv. 1 str. 16M calcium binding protein NP_539585.1 689959 R 224914 CDS NP_539586.1 17986952 1196380 complement(690782..690988) 1 NC_003317.1 hypothetical protein 690988 1196380 BMEI0669 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539586.1 690782 R 224914 CDS NP_539587.1 17986953 1196381 691353..692057 1 NC_003317.1 membrane-associated alkaline phosphatase 692057 1196381 BMEI0670 Brucella melitensis bv. 1 str. 16M membrane-associated alkaline phosphatase NP_539587.1 691353 D 224914 CDS NP_539588.1 17986954 1196382 692475..694043 1 NC_003317.1 integral membrane protein / hemolysin 694043 1196382 BMEI0671 Brucella melitensis bv. 1 str. 16M integral membrane protein / hemolysin NP_539588.1 692475 D 224914 CDS NP_539589.1 17986955 1196383 complement(694115..694393) 1 NC_003317.1 hypothetical protein 694393 1196383 BMEI0672 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539589.1 694115 R 224914 CDS NP_539590.1 17986956 1196384 694674..695678 1 NC_003317.1 thiosulfate-binding protein precursor 695678 1196384 BMEI0673 Brucella melitensis bv. 1 str. 16M thiosulfate-binding protein precursor NP_539590.1 694674 D 224914 CDS NP_539591.1 17986957 1196385 695775..696671 1 NC_003317.1 sulfate transport system permease protein cysT 696671 1196385 BMEI0674 Brucella melitensis bv. 1 str. 16M sulfate transport system permease protein cysT NP_539591.1 695775 D 224914 CDS NP_539592.1 17986958 1196386 696658..697488 1 NC_003317.1 sulfate transport system permease protein CYSW 697488 1196386 BMEI0675 Brucella melitensis bv. 1 str. 16M sulfate transport system permease protein CYSW NP_539592.1 696658 D 224914 CDS NP_539593.1 17986959 1196387 complement(697534..697779) 1 NC_003317.1 hypothetical protein 697779 1196387 BMEI0676 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539593.1 697534 R 224914 CDS NP_539594.1 17986960 1196388 complement(697825..698139) 1 NC_003317.1 hypothetical protein 698139 1196388 BMEI0677 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539594.1 697825 R 224914 CDS NP_539595.1 17986961 1196389 complement(698366..699337) 1 NC_003317.1 low PH-induced protein A 699337 1196389 BMEI0678 Brucella melitensis bv. 1 str. 16M low PH-induced protein A NP_539595.1 698366 R 224914 CDS NP_539596.1 17986962 1196390 complement(699337..701196) 1 NC_003317.1 potassium/proton antiporter rosB 701196 1196390 BMEI0679 Brucella melitensis bv. 1 str. 16M potassium/proton antiporter rosB NP_539596.1 699337 R 224914 CDS NP_539597.1 17986963 1196391 complement(701274..703811) 1 NC_003317.1 part of the preprotein secretory system; forms a complex with protein YajC; SecDFyajC stimulates the proton motive force-driven protein translocation, seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecD/SecF 703811 1196391 BMEI0680 Brucella melitensis bv. 1 str. 16M preprotein translocase subunit SecD/SecF NP_539597.1 701274 R 224914 CDS NP_539598.1 17986964 1196392 complement(703920..704336) 1 NC_003317.1 hypothetical protein 704336 1196392 BMEI0681 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539598.1 703920 R 224914 CDS NP_539599.1 17986965 1196393 704658..707153 1 NC_003317.1 potassium efflux system KEFA 707153 1196393 BMEI0682 Brucella melitensis bv. 1 str. 16M potassium efflux system KEFA NP_539599.1 704658 D 224914 CDS NP_539600.1 17986966 1196394 707260..707550 1 NC_003317.1 hypothetical protein 707550 1196394 BMEI0683 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539600.1 707260 D 224914 CDS NP_539601.1 17986967 1196395 complement(707636..709960) 1 NC_003317.1 sarcosine dehydrogenase 709960 1196395 BMEI0684 Brucella melitensis bv. 1 str. 16M sarcosine dehydrogenase NP_539601.1 707636 R 224914 CDS NP_539602.1 17986968 1196396 complement(710463..711587) 1 NC_003317.1 AraC family transcriptional regulator 711587 1196396 BMEI0685 Brucella melitensis bv. 1 str. 16M AraC family transcriptional regulator NP_539602.1 710463 R 224914 CDS NP_539603.1 17986969 1196397 711877..712827 1 NC_003317.1 LysR family transcriptional regulator 712827 1196397 BMEI0686 Brucella melitensis bv. 1 str. 16M LysR family transcriptional regulator NP_539603.1 711877 D 224914 CDS NP_539604.1 17986970 1196398 712839..713141 1 NC_003317.1 hypothetical protein 713141 1196398 BMEI0687 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539604.1 712839 D 224914 CDS NP_539605.1 17986971 1196399 complement(713537..714469) 1 NC_003317.1 3-hydroxyisobutyrate dehydrogenase 714469 1196399 BMEI0688 Brucella melitensis bv. 1 str. 16M 3-hydroxyisobutyrate dehydrogenase NP_539605.1 713537 R 224914 CDS NP_539606.1 17986972 1196400 complement(714459..715616) 1 NC_003317.1 acyl-CoA dehydrogenase 715616 1196400 BMEI0689 Brucella melitensis bv. 1 str. 16M acyl-CoA dehydrogenase NP_539606.1 714459 R 224914 CDS NP_539607.1 17986973 1196401 715822..717342 1 NC_003317.1 catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation; cobyric acid synthase 717342 1196401 BMEI0690 Brucella melitensis bv. 1 str. 16M cobyric acid synthase NP_539607.1 715822 D 224914 CDS NP_539608.1 17986974 1196402 717668..717844 1 NC_003317.1 hypothetical protein 717844 1196402 BMEI0691 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539608.1 717668 D 224914 CDS NP_539609.1 17986975 1196403 718254..718649 1 NC_003317.1 hypothetical protein 718649 1196403 BMEI0692 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539609.1 718254 D 224914 CDS NP_539610.1 17986976 1196404 718655..719176 1 NC_003317.1 catalyzes ATP-dependent phosphorylation of adenosylcobinamide to form adenosylcobinamide phosphate and the addition of guanosine monophosphate to adenosylcobinamide phosphate to form adenosylcobinamide-GDP; adenosylcobinamide kinase 719176 cobU 1196404 cobU Brucella melitensis bv. 1 str. 16M adenosylcobinamide kinase NP_539610.1 718655 D 224914 CDS NP_539611.1 17986977 1196405 719180..720229 1 NC_003317.1 COBW protein 720229 1196405 BMEI0694 Brucella melitensis bv. 1 str. 16M COBW protein NP_539611.1 719180 D 224914 CDS NP_539612.1 17986978 1196406 720229..724020 1 NC_003317.1 with CobST catalyzes the formation of cobyrinic acid a,c-diamide from hydrogenobyrinic acid a,c-diamide in an ATP-dependent manner; involved in porphyrin and chlorophyll metabolism; vitamin B12 metabolism; cobaltochelatase subunit CobN 724020 cobN 1196406 cobN Brucella melitensis bv. 1 str. 16M cobaltochelatase subunit CobN NP_539612.1 720229 D 224914 CDS NP_539613.1 17986979 1196407 724082..724651 1 NC_003317.1 catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide; cob(I)yrinic acid a,c-diamide adenosyltransferase 724651 1196407 BMEI0696 Brucella melitensis bv. 1 str. 16M cob(I)yrinic acid a,c-diamide adenosyltransferase NP_539613.1 724082 D 224914 CDS NP_539614.1 17986980 1196408 724648..725079 1 NC_003317.1 transporter, DME family 725079 1196408 BMEI0697 Brucella melitensis bv. 1 str. 16M transporter, DME family NP_539614.1 724648 D 224914 CDS NP_539615.1 17986981 1196409 complement(725076..725537) 1 NC_003317.1 transporter 725537 1196409 BMEI0698 Brucella melitensis bv. 1 str. 16M transporter NP_539615.1 725076 R 224914 CDS NP_539616.1 17986982 1196410 725671..726468 1 NC_003317.1 hypothetical protein 726468 1196410 BMEI0699 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539616.1 725671 D 224914 CDS NP_539617.1 17986983 1196411 726461..726856 1 NC_003317.1 precorrin-3B C(17)-methyltransferase 726856 1196411 BMEI0700 Brucella melitensis bv. 1 str. 16M precorrin-3B C(17)-methyltransferase NP_539617.1 726461 D 224914 CDS NP_539618.1 17986984 1196412 726730..727674 1 NC_003317.1 precorrin-4 C(11)-methyltransferase 727674 1196412 BMEI0701 Brucella melitensis bv. 1 str. 16M precorrin-4 C(11)-methyltransferase NP_539618.1 726730 D 224914 CDS NP_539619.1 17986985 1196413 complement(727663..728409) 1 NC_003317.1 CobK/CbiJ; there are 2 pathways for cobalamin (vitamin B12) production, one aerobic (ex. P. denitrificans), the other anaerobic (ex. S. typhimurium); the CobK/CbiJ perform similar reactions in both; the anaerobic pathway includes the use of a chelated cobalt ion in order for ring contraction to occur; CobK thus converts precorrin 6 into dihydro-precorrin 6 while CbiJ converts cobalt-precorrin 6 into cobalt-deihydro-precorrin 6; cobalt-precorrin-6x reductase 728409 1196413 BMEI0702 Brucella melitensis bv. 1 str. 16M cobalt-precorrin-6x reductase NP_539619.1 727663 R 224914 CDS NP_539620.1 17986986 1196414 complement(728396..729505) 1 NC_003317.1 Catalyzes the methylation of C-1 in cobalt-precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A; cobalt-precorrin-6A synthase 729505 cbiD 1196414 cbiD Brucella melitensis bv. 1 str. 16M cobalt-precorrin-6A synthase NP_539620.1 728396 R 224914 CDS NP_539621.1 17986987 1196415 729566..730444 1 NC_003317.1 uroporphyrin-III C-methyltransferase 730444 1196415 BMEI0704 Brucella melitensis bv. 1 str. 16M uroporphyrin-III C-methyltransferase NP_539621.1 729566 D 224914 CDS NP_539622.1 17986988 1196416 730441..731751 1 NC_003317.1 responsible for the amidation of carboxylic groups at position A and C of cobyrinic acid or hydrogenobrynic acid; cobyrinic acid a,c-diamide synthase 731751 1196416 BMEI0705 Brucella melitensis bv. 1 str. 16M cobyrinic acid a,c-diamide synthase NP_539622.1 730441 D 224914 CDS NP_539623.1 17986989 1196417 731748..732746 1 NC_003317.1 aminotransferase family protein 732746 1196417 BMEI0706 Brucella melitensis bv. 1 str. 16M aminotransferase family protein NP_539623.1 731748 D 224914 CDS NP_539624.1 17986990 1196418 732783..733766 1 NC_003317.1 CobD; CbiD in Salmonella; converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group; cobalamin biosynthesis protein 733766 cobD 1196418 cobD Brucella melitensis bv. 1 str. 16M cobalamin biosynthesis protein NP_539624.1 732783 D 224914 CDS NP_539625.1 17986991 1196419 complement(733752..734843) 1 NC_003317.1 leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein precursor 734843 1196419 BMEI0708 Brucella melitensis bv. 1 str. 16M leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein precursor NP_539625.1 733752 R 224914 CDS NP_539626.1 17986992 1196420 734988..735509 1 NC_003317.1 4-hydroxyphenylacetate 3-monooxygenase 735509 1196420 BMEI0709 Brucella melitensis bv. 1 str. 16M 4-hydroxyphenylacetate 3-monooxygenase NP_539626.1 734988 D 224914 CDS NP_539627.1 17986993 1196421 735552..736121 1 NC_003317.1 hypothetical protein 736121 1196421 BMEI0710 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539627.1 735552 D 224914 CDS NP_539628.1 17986994 1196422 736580..737020 1 NC_003317.1 hypothetical protein 737020 1196422 BMEI0711 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539628.1 736580 D 224914 CDS NP_539629.1 17986995 1196423 complement(737058..738764) 1 NC_003317.1 CBIG protein / precorrin-3B C17-methyltransferase 738764 1196423 BMEI0712 Brucella melitensis bv. 1 str. 16M CBIG protein / precorrin-3B C17-methyltransferase NP_539629.1 737058 R 224914 CDS NP_539630.1 17986996 1196424 complement(738749..739483) 1 NC_003317.1 catalyzes the formation of precorrin-3 from precorrin-2; precorrin-2 C(20)-methyltransferase 739483 1196424 BMEI0713 Brucella melitensis bv. 1 str. 16M precorrin-2 C(20)-methyltransferase NP_539630.1 738749 R 224914 CDS NP_539631.1 17986997 1196425 complement(739483..740109) 1 NC_003317.1 catalyzes the interconversion of precorrin-8X and hydrogenobyrinate; precorrin-8X methylmutase 740109 cobH 1196425 cobH Brucella melitensis bv. 1 str. 16M precorrin-8X methylmutase NP_539631.1 739483 R 224914 CDS NP_539632.1 17986998 1196426 complement(740119..741489) 1 NC_003317.1 COBG protein 741489 1196426 BMEI0715 Brucella melitensis bv. 1 str. 16M COBG protein NP_539632.1 740119 R 224914 CDS NP_539633.1 17986999 1196427 741488..742693 1 NC_003317.1 precorrin-6Y C5,15-methyltransferase 742693 1196427 BMEI0716 Brucella melitensis bv. 1 str. 16M precorrin-6Y C5,15-methyltransferase NP_539633.1 741488 D 224914 CDS NP_539634.1 17987000 1196428 complement(742982..743539) 1 NC_003317.1 outer membrane protein 743539 1196428 BMEI0717 Brucella melitensis bv. 1 str. 16M outer membrane protein NP_539634.1 742982 R 224914 CDS NP_539635.1 17987001 1196429 complement(743822..744571) 1 NC_003317.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC 744571 radC 1196429 radC Brucella melitensis bv. 1 str. 16M DNA repair protein RadC NP_539635.1 743822 R 224914 CDS NP_539636.1 17987002 1196430 complement(744627..745457) 1 NC_003317.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase 745457 1196430 BMEI0719 Brucella melitensis bv. 1 str. 16M methionine aminopeptidase NP_539636.1 744627 R 224914 CDS NP_539637.1 17987003 1196431 complement(745454..746170) 1 NC_003317.1 Regulatory factor involved in maltose metabolism; sugar fermentation stimulation protein A 746170 1196431 BMEI0720 Brucella melitensis bv. 1 str. 16M sugar fermentation stimulation protein A NP_539637.1 745454 R 224914 CDS NP_539638.1 17987004 1196432 complement(746493..746777) 1 NC_003317.1 hypothetical protein 746777 1196432 BMEI0721 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539638.1 746493 R 224914 CDS NP_539639.1 17987005 1196433 complement(747295..748008) 1 NC_003317.1 hypothetical protein 748008 1196433 BMEI0722 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539639.1 747295 R 224914 CDS NP_539640.1 17987006 1196434 748782..749282 1 NC_003317.1 hypothetical protein 749282 1196434 BMEI0723 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539640.1 748782 D 224914 CDS NP_539641.1 17987007 1196435 749413..750633 1 NC_003317.1 aminotransferase 750633 1196435 BMEI0724 Brucella melitensis bv. 1 str. 16M aminotransferase NP_539641.1 749413 D 224914 CDS NP_539642.1 17987008 1196436 750769..752088 1 NC_003317.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine; homoserine dehydrogenase 752088 1196436 BMEI0725 Brucella melitensis bv. 1 str. 16M homoserine dehydrogenase NP_539642.1 750769 D 224914 CDS NP_539643.1 17987009 1196437 752481..753467 1 NC_003317.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II 753467 glpX 1196437 glpX Brucella melitensis bv. 1 str. 16M fructose 1,6-bisphosphatase II NP_539643.1 752481 D 224914 CDS NP_539644.1 17987010 1196438 753731..754831 1 NC_003317.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A 754831 ddl 1196438 ddl Brucella melitensis bv. 1 str. 16M D-alanyl-alanine synthetase A NP_539644.1 753731 D 224914 CDS NP_539645.1 17987011 1196439 754881..756665 1 NC_003317.1 single-stranded-DNA-specific exonuclease RECJ 756665 1196439 BMEI0728 Brucella melitensis bv. 1 str. 16M single-stranded-DNA-specific exonuclease RECJ NP_539645.1 754881 D 224914 CDS NP_539646.1 17987012 1196440 757262..757855 1 NC_003317.1 transporter 757855 1196440 BMEI0729 Brucella melitensis bv. 1 str. 16M transporter NP_539646.1 757262 D 224914 CDS NP_539647.1 17987013 1196441 complement(757907..758428) 1 NC_003317.1 lactoylglutathione lyase 758428 1196441 BMEI0730 Brucella melitensis bv. 1 str. 16M lactoylglutathione lyase NP_539647.1 757907 R 224914 CDS NP_539648.1 17987014 1196442 758710..759291 1 NC_003317.1 cold shock protein 759291 1196442 BMEI0731 Brucella melitensis bv. 1 str. 16M cold shock protein NP_539648.1 758710 D 224914 CDS NP_539649.1 17987015 1196443 759695..760144 1 NC_003317.1 hypothetical protein 760144 1196443 BMEI0732 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539649.1 759695 D 224914 CDS NP_539650.1 17987016 1196444 760178..760948 1 NC_003317.1 non-heme chloroperoxidase 760948 1196444 BMEI0733 Brucella melitensis bv. 1 str. 16M non-heme chloroperoxidase NP_539650.1 760178 D 224914 CDS NP_539651.1 17987017 1196445 761057..761947 1 NC_003317.1 serine acetyltransferase 761947 1196445 BMEI0734 Brucella melitensis bv. 1 str. 16M serine acetyltransferase NP_539651.1 761057 D 224914 CDS NP_539652.1 17987018 1196446 762195..762449 1 NC_003317.1 hypothetical protein 762449 1196446 BMEI0735 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539652.1 762195 D 224914 CDS NP_539653.1 17987019 1196447 762720..763247 1 NC_003317.1 ferripyochelin binding protein 763247 1196447 BMEI0736 Brucella melitensis bv. 1 str. 16M ferripyochelin binding protein NP_539653.1 762720 D 224914 CDS NP_539654.1 17987020 1196448 complement(763326..763898) 1 NC_003317.1 hypothetical protein 763898 1196448 BMEI0737 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539654.1 763326 R 224914 CDS NP_539655.1 17987021 1196449 complement(764175..764876) 1 NC_003317.1 hypothetical protein 764876 1196449 BMEI0738 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539655.1 764175 R 224914 CDS NP_539656.1 17987022 1196450 765229..765936 1 NC_003317.1 rhomboid family integral membrane protein 765936 1196450 BMEI0739 Brucella melitensis bv. 1 str. 16M rhomboid family integral membrane protein NP_539656.1 765229 D 224914 CDS NP_539657.1 17987023 1196451 766065..766538 1 NC_003317.1 inosine-5'-monophosphate dehydrogenase 766538 1196451 BMEI0740 Brucella melitensis bv. 1 str. 16M inosine-5'-monophosphate dehydrogenase NP_539657.1 766065 D 224914 CDS NP_539658.1 17987024 1196452 complement(766599..767510) 1 NC_003317.1 23S rRNA methyltransferase RumA 767510 1196452 BMEI0741 Brucella melitensis bv. 1 str. 16M 23S rRNA methyltransferase RumA NP_539658.1 766599 R 224914 CDS NP_539659.2 161511153 1196453 768090..769265 1 NC_003317.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 769265 tuf 1196453 tuf Brucella melitensis bv. 1 str. 16M elongation factor Tu NP_539659.2 768090 D 224914 CDS NP_539660.1 17987026 1196454 769900..770139 1 NC_003317.1 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 770139 secE 1196454 secE Brucella melitensis bv. 1 str. 16M preprotein translocase subunit SecE NP_539660.1 769900 D 224914 CDS NP_539661.1 17987027 1196455 770163..770690 1 NC_003317.1 Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 770690 nusG 1196455 nusG Brucella melitensis bv. 1 str. 16M transcription antitermination protein NusG NP_539661.1 770163 D 224914 CDS NP_539662.1 17987028 1196456 770893..771321 1 NC_003317.1 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 771321 rplK 1196456 rplK Brucella melitensis bv. 1 str. 16M 50S ribosomal protein L11 NP_539662.1 770893 D 224914 CDS NP_539663.1 17987029 1196457 771326..772027 1 NC_003317.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 772027 rplA 1196457 rplA Brucella melitensis bv. 1 str. 16M 50S ribosomal protein L1 NP_539663.1 771326 D 224914 CDS NP_539664.2 161511152 1196458 772418..772936 1 NC_003317.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 772936 rplJ 1196458 rplJ Brucella melitensis bv. 1 str. 16M 50S ribosomal protein L10 NP_539664.2 772418 D 224914 CDS NP_539665.1 17987031 1196459 772988..773362 1 NC_003317.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 773362 rplL 1196459 rplL Brucella melitensis bv. 1 str. 16M 50S ribosomal protein L7/L12 NP_539665.1 772988 D 224914 CDS NP_539666.1 17987032 1196460 773570..777703 1 NC_003317.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 777703 rpoB 1196460 rpoB Brucella melitensis bv. 1 str. 16M DNA-directed RNA polymerase subunit beta NP_539666.1 773570 D 224914 CDS NP_539667.1 17987033 1196461 777852..782054 1 NC_003317.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 782054 1196461 BMEI0750 Brucella melitensis bv. 1 str. 16M DNA-directed RNA polymerase subunit beta' NP_539667.1 777852 D 224914 CDS NP_539668.1 17987034 1196462 complement(782161..782439) 1 NC_003317.1 hypothetical protein 782439 1196462 BMEI0751 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539668.1 782161 R 224914 CDS NP_539669.2 161511151 1196463 782952..783323 1 NC_003317.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 783323 rpsL 1196463 rpsL Brucella melitensis bv. 1 str. 16M 30S ribosomal protein S12 NP_539669.2 782952 D 224914 CDS NP_539670.1 17987036 1196464 783390..783860 1 NC_003317.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 783860 1196464 BMEI0753 Brucella melitensis bv. 1 str. 16M 30S ribosomal protein S7 NP_539670.1 783390 D 224914 CDS NP_539671.1 17987037 1196465 783891..785975 1 NC_003317.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 785975 1196465 BMEI0754 Brucella melitensis bv. 1 str. 16M elongation factor G NP_539671.1 783891 D 224914 CDS NP_539672.1 17987038 1196466 786042..787217 1 NC_003317.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 787217 tuf 1196466 tuf Brucella melitensis bv. 1 str. 16M elongation factor Tu NP_539672.1 786042 D 224914 CDS NP_539673.1 17987039 1196467 787278..787586 1 NC_003317.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 787586 rpsJ 1196467 rpsJ Brucella melitensis bv. 1 str. 16M 30S ribosomal protein S10 NP_539673.1 787278 D 224914 CDS NP_539674.2 161511150 1196468 787616..788329 1 NC_003317.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 788329 rplC 1196468 rplC Brucella melitensis bv. 1 str. 16M 50S ribosomal protein L3 NP_539674.2 787616 D 224914 CDS NP_539675.1 17987041 1196469 788329..788934 1 NC_003317.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 788934 rplD 1196469 rplD Brucella melitensis bv. 1 str. 16M 50S ribosomal protein L4 NP_539675.1 788329 D 224914 CDS NP_539676.1 17987042 1196470 788947..789240 1 NC_003317.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 789240 rplW 1196470 rplW Brucella melitensis bv. 1 str. 16M 50S ribosomal protein L23 NP_539676.1 788947 D 224914 CDS NP_539677.1 17987043 1196471 789262..790095 1 NC_003317.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 790095 rplB 1196471 rplB Brucella melitensis bv. 1 str. 16M 50S ribosomal protein L2 NP_539677.1 789262 D 224914 CDS NP_539678.1 17987044 1196472 790111..790389 1 NC_003317.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 790389 rpsS 1196472 rpsS Brucella melitensis bv. 1 str. 16M 30S ribosomal protein S19 NP_539678.1 790111 D 224914 CDS NP_539679.1 17987045 1196473 790392..790781 1 NC_003317.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 790781 rplV 1196473 rplV Brucella melitensis bv. 1 str. 16M 50S ribosomal protein L22 NP_539679.1 790392 D 224914 CDS NP_539680.1 17987046 1196474 790781..791491 1 NC_003317.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 791491 rpsC 1196474 rpsC Brucella melitensis bv. 1 str. 16M 30S ribosomal protein S3 NP_539680.1 790781 D 224914 CDS NP_539681.1 17987047 1196475 791530..791943 1 NC_003317.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 791943 rplP 1196475 rplP Brucella melitensis bv. 1 str. 16M 50S ribosomal protein L16 NP_539681.1 791530 D 224914 CDS NP_539682.1 17987048 1196476 791956..792156 1 NC_003317.1 one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 792156 1196476 BMEI0765 Brucella melitensis bv. 1 str. 16M 50S ribosomal protein L29 NP_539682.1 791956 D 224914 CDS NP_539683.1 17987049 1196477 792169..792411 1 NC_003317.1 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 792411 rpsQ 1196477 rpsQ Brucella melitensis bv. 1 str. 16M 30S ribosomal protein S17 NP_539683.1 792169 D 224914 CDS NP_539684.1 17987050 1196478 792480..792848 1 NC_003317.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 792848 rplN 1196478 rplN Brucella melitensis bv. 1 str. 16M 50S ribosomal protein L14 NP_539684.1 792480 D 224914 CDS NP_539685.1 17987051 1196479 792861..793172 1 NC_003317.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 793172 rplX 1196479 rplX Brucella melitensis bv. 1 str. 16M 50S ribosomal protein L24 NP_539685.1 792861 D 224914 CDS NP_539686.1 17987052 1196480 793165..793722 1 NC_003317.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 793722 rplE 1196480 rplE Brucella melitensis bv. 1 str. 16M 50S ribosomal protein L5 NP_539686.1 793165 D 224914 CDS NP_539687.1 17987053 1196481 793750..794055 1 NC_003317.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 794055 rpsN 1196481 rpsN Brucella melitensis bv. 1 str. 16M 30S ribosomal protein S14 NP_539687.1 793750 D 224914 CDS NP_539688.1 17987054 1196482 794066..794464 1 NC_003317.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 794464 rpsH 1196482 rpsH Brucella melitensis bv. 1 str. 16M 30S ribosomal protein S8 NP_539688.1 794066 D 224914 CDS NP_539689.1 17987055 1196483 794503..795036 1 NC_003317.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 795036 rplF 1196483 rplF Brucella melitensis bv. 1 str. 16M 50S ribosomal protein L6 NP_539689.1 794503 D 224914 CDS NP_539690.1 17987056 1196484 795049..795411 1 NC_003317.1 binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 795411 rplR 1196484 rplR Brucella melitensis bv. 1 str. 16M 50S ribosomal protein L18 NP_539690.1 795049 D 224914 CDS NP_539691.1 17987057 1196485 795453..796013 1 NC_003317.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 796013 rpsE 1196485 rpsE Brucella melitensis bv. 1 str. 16M 30S ribosomal protein S5 NP_539691.1 795453 D 224914 CDS NP_539692.1 17987058 1196486 796131..796328 1 NC_003317.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 796328 rpmD 1196486 rpmD Brucella melitensis bv. 1 str. 16M 50S ribosomal protein L30 NP_539692.1 796131 D 224914 CDS NP_539693.1 17987059 1196487 796349..796819 1 NC_003317.1 late assembly protein; 50S ribosomal protein L15 796819 rplO 1196487 rplO Brucella melitensis bv. 1 str. 16M 50S ribosomal protein L15 NP_539693.1 796349 D 224914 CDS NP_539694.1 17987060 1196488 796980..798320 1 NC_003317.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 798320 secY 1196488 secY Brucella melitensis bv. 1 str. 16M preprotein translocase subunit SecY NP_539694.1 796980 D 224914 CDS NP_539695.1 17987061 1196489 798317..798901 1 NC_003317.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 798901 adk 1196489 adk Brucella melitensis bv. 1 str. 16M adenylate kinase NP_539695.1 798317 D 224914 CDS NP_539696.1 17987062 1196490 799211..799579 1 NC_003317.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 799579 rpsM 1196490 rpsM Brucella melitensis bv. 1 str. 16M 30S ribosomal protein S13 NP_539696.1 799211 D 224914 CDS NP_539697.1 17987063 1196491 799707..800096 1 NC_003317.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 800096 1196491 BMEI0780 Brucella melitensis bv. 1 str. 16M 30S ribosomal protein S11 NP_539697.1 799707 D 224914 CDS NP_539698.1 17987064 1196492 800212..801225 1 NC_003317.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 801225 1196492 BMEI0781 Brucella melitensis bv. 1 str. 16M DNA-directed RNA polymerase subunit alpha NP_539698.1 800212 D 224914 CDS NP_539699.1 17987065 1196493 801387..801815 1 NC_003317.1 is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 801815 rplQ 1196493 rplQ Brucella melitensis bv. 1 str. 16M 50S ribosomal protein L17 NP_539699.1 801387 D 224914 CDS NP_539700.1 17987066 1196494 802095..803519 1 NC_003317.1 protease Do 803519 1196494 BMEI0783 Brucella melitensis bv. 1 str. 16M protease Do NP_539700.1 802095 D 224914 CDS NP_539701.1 17987067 1196495 803606..804979 1 NC_003317.1 recombination factor protein RarA 804979 1196495 BMEI0784 Brucella melitensis bv. 1 str. 16M recombination factor protein RarA NP_539701.1 803606 D 224914 CDS NP_539702.1 17987068 1196496 805103..805687 1 NC_003317.1 transcriptional regulator 805687 1196496 BMEI0785 Brucella melitensis bv. 1 str. 16M transcriptional regulator NP_539702.1 805103 D 224914 CDS NP_539703.1 17987069 1196497 805738..806436 1 NC_003317.1 hypothetical protein 806436 1196497 BMEI0786 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539703.1 805738 D 224914 CDS NP_539704.2 229220681 1196498 806767..807852 1 NC_003317.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 807852 recA 1196498 recA Brucella melitensis bv. 1 str. 16M recombinase A NP_539704.2 806767 D 224914 CDS NP_539705.1 17987071 1196499 complement(808080..808235) 1 NC_003317.1 hypothetical protein 808235 1196499 BMEI0788 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539705.1 808080 R 224914 CDS NP_539706.1 17987072 1196500 808245..810902 1 NC_003317.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 810902 alaS 1196500 alaS Brucella melitensis bv. 1 str. 16M alanyl-tRNA synthetase NP_539706.1 808245 D 224914 CDS NP_539707.1 17987073 1196501 complement(811054..812499) 1 NC_003317.1 alkaline phosphatase 812499 1196501 BMEI0790 Brucella melitensis bv. 1 str. 16M alkaline phosphatase NP_539707.1 811054 R 224914 CDS NP_539708.1 17987074 1196502 complement(812721..813935) 1 NC_003317.1 Converts isocitrate to alpha ketoglutarate; isocitrate dehydrogenase 813935 1196502 BMEI0791 Brucella melitensis bv. 1 str. 16M isocitrate dehydrogenase NP_539708.1 812721 R 224914 CDS NP_539709.1 17987075 1196503 complement(814063..814473) 1 NC_003317.1 intracellular proteinase I 814473 1196503 BMEI0792 Brucella melitensis bv. 1 str. 16M intracellular proteinase I NP_539709.1 814063 R 224914 CDS NP_539710.1 17987076 1196504 complement(814562..815206) 1 NC_003317.1 protease I 815206 1196504 BMEI0793 Brucella melitensis bv. 1 str. 16M protease I NP_539710.1 814562 R 224914 CDS NP_539711.1 17987077 1196505 815326..816156 1 NC_003317.1 SpoU rRNA methylase family 816156 1196505 BMEI0794 Brucella melitensis bv. 1 str. 16M SpoU rRNA methylase family NP_539711.1 815326 D 224914 CDS NP_539712.1 17987078 1196506 816153..816986 1 NC_003317.1 converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 816986 1196506 BMEI0795 Brucella melitensis bv. 1 str. 16M glutamate racemase NP_539712.1 816153 D 224914 CDS NP_539713.1 17987079 1196507 817132..818121 1 NC_003317.1 hypothetical protein 818121 1196507 BMEI0796 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539713.1 817132 D 224914 CDS NP_539714.1 17987080 1196508 818358..820406 1 NC_003317.1 transporter 820406 1196508 BMEI0797 Brucella melitensis bv. 1 str. 16M transporter NP_539714.1 818358 D 224914 CDS NP_539715.1 17987081 1196509 820569..820955 1 NC_003317.1 hypothetical protein 820955 1196509 BMEI0798 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539715.1 820569 D 224914 CDS NP_539716.1 17987082 1196510 complement(821062..823254) 1 NC_003317.1 MDM; functions in conversion of succinate to propionate; methylmalonyl-CoA mutase 823254 1196510 BMEI0799 Brucella melitensis bv. 1 str. 16M methylmalonyl-CoA mutase NP_539716.1 821062 R 224914 CDS NP_539717.1 17987083 1196511 complement(823261..825264) 1 NC_003317.1 propionyl-CoA carboxylase subunit alpha 825264 1196511 BMEI0800 Brucella melitensis bv. 1 str. 16M propionyl-CoA carboxylase subunit alpha NP_539717.1 823261 R 224914 CDS NP_539718.1 17987084 1196512 complement(825349..826881) 1 NC_003317.1 propionyl-CoA carboxylase subunit beta 826881 1196512 BMEI0801 Brucella melitensis bv. 1 str. 16M propionyl-CoA carboxylase subunit beta NP_539718.1 825349 R 224914 CDS NP_539719.1 17987085 1196513 827036..828448 1 NC_003317.1 MerR family transcriptional regulator 828448 1196513 BMEI0802 Brucella melitensis bv. 1 str. 16M MerR family transcriptional regulator NP_539719.1 827036 D 224914 CDS NP_539720.1 17987086 1196514 complement(828451..829077) 1 NC_003317.1 hypothetical protein 829077 1196514 BMEI0803 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539720.1 828451 R 224914 CDS NP_539721.1 17987087 1196515 complement(829332..829799) 1 NC_003317.1 NADPH-dependent; catalyzes the reduction of 7-cyano-7-deazaguanine to 7-aminomethyl-7-deazaguanine in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 829799 1196515 BMEI0804 Brucella melitensis bv. 1 str. 16M 7-cyano-7-deazaguanine reductase NP_539721.1 829332 R 224914 CDS NP_539722.1 17987088 1196516 complement(830095..830409) 1 NC_003317.1 hypothetical protein 830409 1196516 BMEI0805 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539722.1 830095 R 224914 CDS NP_539723.1 17987089 1196517 complement(830480..830815) 1 NC_003317.1 hypothetical protein 830815 1196517 BMEI0806 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539723.1 830480 R 224914 CDS NP_539724.1 17987090 1196518 complement(830842..831207) 1 NC_003317.1 hypothetical protein 831207 1196518 BMEI0807 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539724.1 830842 R 224914 CDS NP_539725.1 17987091 1196519 831445..831831 1 NC_003317.1 MerR family transcriptional regulator 831831 1196519 BMEI0808 Brucella melitensis bv. 1 str. 16M MerR family transcriptional regulator NP_539725.1 831445 D 224914 CDS NP_539726.1 17987092 1196520 complement(832246..832809) 1 NC_003317.1 hypothetical protein 832809 1196520 BMEI0809 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539726.1 832246 R 224914 CDS NP_539727.1 17987093 1196521 833002..833796 1 NC_003317.1 hypothetical protein 833796 1196521 BMEI0810 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539727.1 833002 D 224914 CDS NP_539728.1 17987094 1196522 834312..835721 1 NC_003317.1 L-serine dehydratase 1 835721 1196522 BMEI0811 Brucella melitensis bv. 1 str. 16M L-serine dehydratase 1 NP_539728.1 834312 D 224914 CDS NP_539729.1 17987095 1196523 835810..836247 1 NC_003317.1 hypothetical protein 836247 1196523 BMEI0812 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539729.1 835810 D 224914 CDS NP_539730.1 17987096 1196524 complement(836361..836702) 1 NC_003317.1 hypothetical protein 836702 1196524 BMEI0813 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539730.1 836361 R 224914 CDS NP_539731.1 17987097 1196525 complement(836734..838152) 1 NC_003317.1 penicillin-binding protein 6 (D-alanyl-D-alanine carboxypeptidase fraction C) 838152 1196525 BMEI0814 Brucella melitensis bv. 1 str. 16M penicillin-binding protein 6 (D-alanyl-D-alanine carboxypeptidase fraction C) NP_539731.1 836734 R 224914 CDS NP_539732.1 17987098 1196526 838578..838988 1 NC_003317.1 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA; ATP-dependent Clp protease adaptor protein ClpS 838988 clpS 1196526 clpS Brucella melitensis bv. 1 str. 16M ATP-dependent Clp protease adaptor protein ClpS NP_539732.1 838578 D 224914 CDS NP_539733.1 17987099 1196527 838995..841469 1 NC_003317.1 ATP-dependent Clp protease ATP-binding subunit ClpA 841469 1196527 BMEI0816 Brucella melitensis bv. 1 str. 16M ATP-dependent Clp protease ATP-binding subunit ClpA NP_539733.1 838995 D 224914 CDS NP_539734.1 17987100 1196528 complement(841576..842025) 1 NC_003317.1 bis(5'-nucleosyl)-tetraphosphatase 842025 1196528 BMEI0817 Brucella melitensis bv. 1 str. 16M bis(5'-nucleosyl)-tetraphosphatase NP_539734.1 841576 R 224914 CDS NP_539735.1 17987101 1196529 complement(842070..843257) 1 NC_003317.1 hypothetical protein 843257 1196529 BMEI0818 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539735.1 842070 R 224914 CDS NP_539736.1 17987102 1196530 complement(843312..844052) 1 NC_003317.1 glycerophosphoryl diester phosphodiesterase 844052 1196530 BMEI0819 Brucella melitensis bv. 1 str. 16M glycerophosphoryl diester phosphodiesterase NP_539736.1 843312 R 224914 CDS NP_539737.1 17987103 1196531 complement(844054..844518) 1 NC_003317.1 translation initiation inhibitor 844518 1196531 BMEI0820 Brucella melitensis bv. 1 str. 16M translation initiation inhibitor NP_539737.1 844054 R 224914 CDS NP_539738.1 17987104 1196532 844711..845505 1 NC_003317.1 hypothetical protein 845505 1196532 BMEI0821 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539738.1 844711 D 224914 CDS NP_539739.1 17987105 1196533 845743..846111 1 NC_003317.1 hypothetical protein 846111 1196533 BMEI0822 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539739.1 845743 D 224914 CDS NP_539740.2 161511149 1196534 846334..847104 1 NC_003317.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 847104 rpsB 1196534 rpsB Brucella melitensis bv. 1 str. 16M 30S ribosomal protein S2 NP_539740.2 846334 D 224914 CDS NP_539741.2 161511148 1196535 847294..848211 1 NC_003317.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 848211 tsf 1196535 tsf Brucella melitensis bv. 1 str. 16M elongation factor Ts NP_539741.2 847294 D 224914 CDS NP_539742.2 161511147 1196536 848378..849100 1 NC_003317.1 Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 849100 pyrH 1196536 pyrH Brucella melitensis bv. 1 str. 16M uridylate kinase NP_539742.2 848378 D 224914 CDS NP_539743.1 17987109 1196537 849136..849696 1 NC_003317.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 849696 frr 1196537 frr Brucella melitensis bv. 1 str. 16M ribosome recycling factor NP_539743.1 849136 D 224914 CDS NP_539744.1 17987110 1196538 849741..850505 1 NC_003317.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 850505 1196538 BMEI0827 Brucella melitensis bv. 1 str. 16M undecaprenyl pyrophosphate synthase NP_539744.1 849741 D 224914 CDS NP_539745.1 17987111 1196539 850586..851422 1 NC_003317.1 phosphatidate cytidylyltransferase 851422 1196539 BMEI0828 Brucella melitensis bv. 1 str. 16M phosphatidate cytidylyltransferase NP_539745.1 850586 D 224914 CDS NP_539746.1 17987112 1196540 851489..852628 1 NC_003317.1 membrane metalloprotease 852628 1196540 BMEI0829 Brucella melitensis bv. 1 str. 16M membrane metalloprotease NP_539746.1 851489 D 224914 CDS NP_539747.1 17987113 1196541 852964..855309 1 NC_003317.1 hypothetical protein 855309 1196541 BMEI0830 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539747.1 852964 D 224914 CDS NP_539748.1 17987114 1196542 855363..856418 1 NC_003317.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 856418 lpxD 1196542 lpxD Brucella melitensis bv. 1 str. 16M UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase NP_539748.1 855363 D 224914 CDS NP_539749.1 17987115 1196543 856363..856884 1 NC_003317.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 856884 fabZ 1196543 fabZ Brucella melitensis bv. 1 str. 16M (3R)-hydroxymyristoyl-ACP dehydratase NP_539749.1 856363 D 224914 CDS NP_539750.1 17987116 1196544 856881..857729 1 NC_003317.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis; UDP-N-acetylglucosamine acyltransferase 857729 1196544 BMEI0833 Brucella melitensis bv. 1 str. 16M UDP-N-acetylglucosamine acyltransferase NP_539750.1 856881 D 224914 CDS NP_539751.1 17987117 1196545 857710..858612 1 NC_003317.1 hypothetical protein 858612 1196545 BMEI0834 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539751.1 857710 D 224914 CDS NP_539752.1 17987118 1196546 858609..859796 1 NC_003317.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM; lipid-A-disaccharide synthase 859796 lpxB 1196546 lpxB Brucella melitensis bv. 1 str. 16M lipid-A-disaccharide synthase NP_539752.1 858609 D 224914 CDS NP_539753.2 161511146 1196547 complement(859969..861261) 1 NC_003317.1 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; type II citrate synthase 861261 gltA 1196547 gltA Brucella melitensis bv. 1 str. 16M type II citrate synthase NP_539753.2 859969 R 224914 CDS NP_539754.1 17987120 1196548 complement(861490..862995) 1 NC_003317.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 862995 gltX 1196548 gltX Brucella melitensis bv. 1 str. 16M glutamyl-tRNA synthetase NP_539754.1 861490 R 224914 CDS NP_539755.1 17987121 1196549 863132..863968 1 NC_003317.1 competence protein ComE 863968 1196549 BMEI0838 Brucella melitensis bv. 1 str. 16M competence protein ComE NP_539755.1 863132 D 224914 CDS NP_539756.1 17987122 1196550 863965..865662 1 NC_003317.1 competence protein ComE 865662 1196550 BMEI0839 Brucella melitensis bv. 1 str. 16M competence protein ComE NP_539756.1 863965 D 224914 CDS NP_539757.1 17987123 1196551 complement(865656..866378) 1 NC_003317.1 Represses a number of genes involved in the response to DNA damage; LexA repressor 866378 1196551 BMEI0840 Brucella melitensis bv. 1 str. 16M LexA repressor NP_539757.1 865656 R 224914 CDS NP_539758.1 17987124 1196552 complement(866626..867840) 1 NC_003317.1 molybdopterin biosynthesis MOEA protein 867840 1196552 BMEI0841 Brucella melitensis bv. 1 str. 16M molybdopterin biosynthesis MOEA protein NP_539758.1 866626 R 224914 CDS NP_539759.1 17987125 1196553 complement(867936..868433) 1 NC_003317.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MoaC 868433 moaC 1196553 moaC Brucella melitensis bv. 1 str. 16M molybdenum cofactor biosynthesis protein MoaC NP_539759.1 867936 R 224914 CDS NP_539760.2 161511145 1196554 complement(868430..869236) 1 NC_003317.1 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water; indole-3-glycerol phosphate synthase 869236 trpC 1196554 trpC Brucella melitensis bv. 1 str. 16M indole-3-glycerol phosphate synthase NP_539760.2 868430 R 224914 CDS NP_539761.1 17987127 1196555 complement(869253..870281) 1 NC_003317.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase 870281 trpD 1196555 trpD Brucella melitensis bv. 1 str. 16M anthranilate phosphoribosyltransferase NP_539761.1 869253 R 224914 CDS NP_539762.1 17987128 1196556 complement(870287..872173) 1 NC_003317.1 peptidyl-prolyl cis-trans isomerase D 872173 1196556 BMEI0845 Brucella melitensis bv. 1 str. 16M peptidyl-prolyl cis-trans isomerase D NP_539762.1 870287 R 224914 CDS NP_539763.1 17987129 1196557 872392..873156 1 NC_003317.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 873156 tpiA 1196557 tpiA Brucella melitensis bv. 1 str. 16M triosephosphate isomerase NP_539763.1 872392 D 224914 CDS NP_539764.2 161511144 1196558 873256..873702 1 NC_003317.1 preprotein translocase subunit SecG 873702 secG 1196558 secG Brucella melitensis bv. 1 str. 16M preprotein translocase subunit SecG NP_539764.2 873256 D 224914 CDS NP_539765.1 17987131 1196559 874000..874647 1 NC_003317.1 carnitine operon oxidoreductase CaiA 874647 1196559 BMEI0848 Brucella melitensis bv. 1 str. 16M carnitine operon oxidoreductase CaiA NP_539765.1 874000 D 224914 CDS NP_539766.1 17987132 1196560 874917..876545 1 NC_003317.1 CTP synthase; CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 876545 pyrG 1196560 pyrG Brucella melitensis bv. 1 str. 16M CTP synthetase NP_539766.1 874917 D 224914 CDS NP_539767.1 17987133 1196561 876651..877484 1 NC_003317.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase 877484 1196561 BMEI0850 Brucella melitensis bv. 1 str. 16M 2-dehydro-3-deoxyphosphooctonate aldolase NP_539767.1 876651 D 224914 CDS NP_539768.1 17987134 1196562 877671..878948 1 NC_003317.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 878948 eno 1196562 eno Brucella melitensis bv. 1 str. 16M phosphopyruvate hydratase NP_539768.1 877671 D 224914 CDS NP_539769.1 17987135 1196563 879276..879866 1 NC_003317.1 methyltransferase 879866 1196563 BMEI0852 Brucella melitensis bv. 1 str. 16M methyltransferase NP_539769.1 879276 D 224914 CDS NP_539770.1 17987136 1196564 880138..880467 1 NC_003317.1 hypothetical protein 880467 1196564 BMEI0853 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539770.1 880138 D 224914 CDS NP_539771.1 17987137 1196565 880606..881646 1 NC_003317.1 pyruvate dehydrogenase E1 component subunit alpha 881646 1196565 BMEI0854 Brucella melitensis bv. 1 str. 16M pyruvate dehydrogenase E1 component subunit alpha NP_539771.1 880606 D 224914 CDS NP_539772.1 17987138 1196566 881665..883050 1 NC_003317.1 catalyzes the oxidative decarboxylation of pyruvate with concomitant acetylation of a lipoic acid-containing dihydrolipoamide acetyltransferase within the complex. The E1 component of the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase(E2) and lipoamide dehydrogenase; pyruvate dehydrogenase subunit beta 883050 1196566 BMEI0855 Brucella melitensis bv. 1 str. 16M pyruvate dehydrogenase subunit beta NP_539772.1 881665 D 224914 CDS NP_539773.1 17987139 1196567 883068..884411 1 NC_003317.1 branched-chain alpha-keto acid dehydrogenase E2 subunit 884411 1196567 BMEI0856 Brucella melitensis bv. 1 str. 16M branched-chain alpha-keto acid dehydrogenase E2 subunit NP_539773.1 883068 D 224914 CDS NP_539774.1 17987140 1196568 884359..885957 1 NC_003317.1 E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase 885957 1196568 BMEI0857 Brucella melitensis bv. 1 str. 16M dihydrolipoamide dehydrogenase NP_539774.1 884359 D 224914 CDS NP_539775.1 17987141 1196569 886040..886237 1 NC_003317.1 hypothetical protein 886237 1196569 BMEI0858 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539775.1 886040 D 224914 CDS NP_539776.1 17987142 1196570 886347..887315 1 NC_003317.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 887315 1196570 BMEI0859 Brucella melitensis bv. 1 str. 16M lipoyl synthase NP_539776.1 886347 D 224914 CDS NP_539777.1 17987143 1196571 887321..887779 1 NC_003317.1 hypothetical protein 887779 1196571 BMEI0860 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539777.1 887321 D 224914 CDS NP_539778.1 17987144 1196572 complement(887761..888579) 1 NC_003317.1 glucose 1-dehydrogenase 888579 1196572 BMEI0861 Brucella melitensis bv. 1 str. 16M glucose 1-dehydrogenase NP_539778.1 887761 R 224914 CDS NP_539779.1 17987145 1196573 complement(888656..889153) 1 NC_003317.1 competence-damage protein 889153 1196573 BMEI0862 Brucella melitensis bv. 1 str. 16M competence-damage protein NP_539779.1 888656 R 224914 CDS NP_539780.2 161511143 1196574 complement(889150..890379) 1 NC_003317.1 bifunctional enzyme involved in formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate and 2-C-methyl-D-erythritol 2,4-cyclodiphosphate and CMP from 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; binds divalent cations; bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 890379 ispDF 1196574 ispDF Brucella melitensis bv. 1 str. 16M bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase NP_539780.2 889150 R 224914 CDS NP_539781.1 17987147 1196575 890517..891518 1 NC_003317.1 nitrogen regulation protein NIFR3 891518 1196575 BMEI0864 Brucella melitensis bv. 1 str. 16M nitrogen regulation protein NIFR3 NP_539781.1 890517 D 224914 CDS NP_539782.1 17987148 1196576 891518..892660 1 NC_003317.1 nitrogen regulation protein NTRB 892660 1196576 BMEI0865 Brucella melitensis bv. 1 str. 16M nitrogen regulation protein NTRB NP_539782.1 891518 D 224914 CDS NP_539783.1 17987149 1196577 892546..894132 1 NC_003317.1 nitrogen assimilation regulatory protein 894132 1196577 BMEI0866 Brucella melitensis bv. 1 str. 16M nitrogen assimilation regulatory protein NP_539783.1 892546 D 224914 CDS NP_539784.1 17987150 1196578 894292..896547 1 NC_003317.1 nitrogen regulation protein NTRY 896547 1196578 BMEI0867 Brucella melitensis bv. 1 str. 16M nitrogen regulation protein NTRY NP_539784.1 894292 D 224914 CDS NP_539785.1 17987151 1196579 896549..897910 1 NC_003317.1 nitrogen assimilation regulatory protein NTRX 897910 1196579 BMEI0868 Brucella melitensis bv. 1 str. 16M nitrogen assimilation regulatory protein NTRX NP_539785.1 896549 D 224914 CDS NP_539786.1 17987152 1196580 897935..899311 1 NC_003317.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane protein 899311 trkA 1196580 trkA Brucella melitensis bv. 1 str. 16M potassium transporter peripheral membrane protein NP_539786.1 897935 D 224914 CDS NP_539787.1 17987153 1196581 899426..900190 1 NC_003317.1 hypothetical protein 900190 1196581 BMEI0870 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539787.1 899426 D 224914 CDS NP_539788.1 17987154 1196582 900219..900413 1 NC_003317.1 hypothetical protein 900413 1196582 BMEI0871 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539788.1 900219 D 224914 CDS NP_539789.1 17987155 1196583 900419..900655 1 NC_003317.1 Stimulates the elongation of poly(A) tails; RNA-binding protein Hfq 900655 hfq 1196583 hfq Brucella melitensis bv. 1 str. 16M RNA-binding protein Hfq NP_539789.1 900419 D 224914 CDS NP_539790.1 17987156 1196584 900747..902264 1 NC_003317.1 GTP-binding protein HflX 902264 1196584 BMEI0873 Brucella melitensis bv. 1 str. 16M GTP-binding protein HflX NP_539790.1 900747 D 224914 CDS NP_539791.2 161511142 1196585 902369..902998 1 NC_003317.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 902998 clpP 1196585 clpP Brucella melitensis bv. 1 str. 16M ATP-dependent Clp protease proteolytic subunit NP_539791.2 902369 D 224914 CDS NP_539792.1 17987158 1196586 903380..904654 1 NC_003317.1 binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 904654 clpX 1196586 clpX Brucella melitensis bv. 1 str. 16M ATP-dependent protease ATP-binding subunit ClpX NP_539792.1 903380 D 224914 CDS NP_539793.1 17987159 1196587 905053..907524 1 NC_003317.1 ATP-dependent protease LA 907524 1196587 BMEI0876 Brucella melitensis bv. 1 str. 16M ATP-dependent protease LA NP_539793.1 905053 D 224914 CDS NP_539794.1 17987160 1196588 907699..907980 1 NC_003317.1 DNA-binding protein HU-alpha 907980 1196588 BMEI0877 Brucella melitensis bv. 1 str. 16M DNA-binding protein HU-alpha NP_539794.1 907699 D 224914 CDS NP_539795.1 17987161 1196589 complement(908167..911091) 1 NC_003317.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 911091 uvrA 1196589 uvrA Brucella melitensis bv. 1 str. 16M excinuclease ABC subunit A NP_539795.1 908167 R 224914 CDS NP_539796.1 17987162 1196590 complement(911222..911422) 1 NC_003317.1 hypothetical protein 911422 1196590 BMEI0879 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539796.1 911222 R 224914 CDS NP_539797.1 17987163 1196591 911990..912496 1 NC_003317.1 single-strand binding protein 912496 1196591 BMEI0880 Brucella melitensis bv. 1 str. 16M single-strand binding protein NP_539797.1 911990 D 224914 CDS NP_539798.1 17987164 1196592 complement(913182..913943) 1 NC_003317.1 GntR family transcriptional regulator 913943 1196592 BMEI0881 Brucella melitensis bv. 1 str. 16M GntR family transcriptional regulator NP_539798.1 913182 R 224914 CDS NP_539799.1 17987165 1196593 914130..914708 1 NC_003317.1 phosphonate ABC transporter ATP-binding protein 914708 1196593 BMEI0882 Brucella melitensis bv. 1 str. 16M phosphonate ABC transporter ATP-binding protein NP_539799.1 914130 D 224914 CDS NP_539800.1 17987166 1196594 complement(914799..915428) 1 NC_003317.1 multiple antibiotic resistance protein MARC 915428 1196594 BMEI0883 Brucella melitensis bv. 1 str. 16M multiple antibiotic resistance protein MARC NP_539800.1 914799 R 224914 CDS NP_539801.2 161511141 1196595 915716..918484 1 NC_003317.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A 918484 1196595 BMEI0884 Brucella melitensis bv. 1 str. 16M DNA gyrase subunit A NP_539801.2 915716 D 224914 CDS NP_539802.1 17987168 1196596 complement(918651..918800) 1 NC_003317.1 hypothetical protein 918800 1196596 BMEI0885 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539802.1 918651 R 224914 CDS NP_539803.1 17987169 1196597 918995..919489 1 NC_003317.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 919489 coaD 1196597 coaD Brucella melitensis bv. 1 str. 16M phosphopantetheine adenylyltransferase NP_539803.1 918995 D 224914 CDS NP_539804.1 17987170 1196598 919570..920100 1 NC_003317.1 peptidyl-prolyl cis-trans isomerase 920100 1196598 BMEI0887 Brucella melitensis bv. 1 str. 16M peptidyl-prolyl cis-trans isomerase NP_539804.1 919570 D 224914 CDS NP_539805.1 17987171 1196599 920139..920669 1 NC_003317.1 peptidyl-prolyl cis-trans isomerase A 920669 1196599 BMEI0888 Brucella melitensis bv. 1 str. 16M peptidyl-prolyl cis-trans isomerase A NP_539805.1 920139 D 224914 CDS NP_539806.1 17987172 1196600 920791..921882 1 NC_003317.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine--tRNA ribosyltransferase-isomerase 921882 queA 1196600 queA Brucella melitensis bv. 1 str. 16M S-adenosylmethionine--tRNA ribosyltransferase-isomerase NP_539806.1 920791 D 224914 CDS NP_539807.1 17987173 1196601 921879..923012 1 NC_003317.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 923012 tgt 1196601 tgt Brucella melitensis bv. 1 str. 16M queuine tRNA-ribosyltransferase NP_539807.1 921879 D 224914 CDS NP_539808.1 17987174 1196602 complement(923049..923615) 1 NC_003317.1 TetR family transcriptional regulator 923615 1196602 BMEI0891 Brucella melitensis bv. 1 str. 16M TetR family transcriptional regulator NP_539808.1 923049 R 224914 CDS NP_539809.1 17987175 1196603 923810..924904 1 NC_003317.1 membrane fusion protein MTRC 924904 1196603 BMEI0892 Brucella melitensis bv. 1 str. 16M membrane fusion protein MTRC NP_539809.1 923810 D 224914 CDS NP_539810.1 17987176 1196604 924914..928003 1 NC_003317.1 acriflavin resistance protein B 928003 1196604 BMEI0893 Brucella melitensis bv. 1 str. 16M acriflavin resistance protein B NP_539810.1 924914 D 224914 CDS NP_539811.1 17987177 1196605 928084..929067 1 NC_003317.1 alkanal monooxygenase subunit alpha 929067 1196605 BMEI0894 Brucella melitensis bv. 1 str. 16M alkanal monooxygenase subunit alpha NP_539811.1 928084 D 224914 CDS NP_539812.1 17987178 1196606 complement(929037..929273) 1 NC_003317.1 LysR family transcriptional regulator 929273 1196606 BMEI0895 Brucella melitensis bv. 1 str. 16M LysR family transcriptional regulator NP_539812.1 929037 R 224914 CDS NP_539813.1 17987179 1196607 complement(929117..929968) 1 NC_003317.1 LysR family transcriptional regulator 929968 1196607 BMEI0896 Brucella melitensis bv. 1 str. 16M LysR family transcriptional regulator NP_539813.1 929117 R 224914 CDS NP_539814.1 17987180 1196608 930070..931254 1 NC_003317.1 glutaryl-CoA dehydrogenase 931254 1196608 BMEI0897 Brucella melitensis bv. 1 str. 16M glutaryl-CoA dehydrogenase NP_539814.1 930070 D 224914 CDS NP_539815.1 17987181 1196609 931276..932478 1 NC_003317.1 acyl-CoA transferase 932478 1196609 BMEI0898 Brucella melitensis bv. 1 str. 16M acyl-CoA transferase NP_539815.1 931276 D 224914 CDS NP_539816.1 17987182 1196610 933005..933580 1 NC_003317.1 Phage-related DNA binding protein 933580 1196610 BMEI0899 Brucella melitensis bv. 1 str. 16M Phage-related DNA binding protein NP_539816.1 933005 D 224914 CDS NP_539817.1 17987183 1196611 933957..934199 1 NC_003317.1 hypothetical protein 934199 1196611 BMEI0900 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539817.1 933957 D 224914 CDS NP_539818.1 17987184 1196612 934707..935324 1 NC_003317.1 resolvase 935324 1196612 BMEI0901 Brucella melitensis bv. 1 str. 16M resolvase NP_539818.1 934707 D 224914 CDS NP_539819.1 17987185 1196613 935275..935505 1 NC_003317.1 recombinase 935505 1196613 BMEI0902 Brucella melitensis bv. 1 str. 16M recombinase NP_539819.1 935275 D 224914 CDS NP_539820.1 17987186 1196614 935903..937246 1 NC_003317.1 hypothetical protein 937246 1196614 BMEI0903 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539820.1 935903 D 224914 CDS NP_539821.1 17987187 1196615 complement(937691..937936) 1 NC_003317.1 hypothetical protein 937936 1196615 BMEI0904 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539821.1 937691 R 224914 CDS NP_539822.1 17987188 1196616 938429..938650 1 NC_003317.1 hypothetical protein 938650 1196616 BMEI0905 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539822.1 938429 D 224914 CDS NP_539823.1 17987189 1196617 complement(938992..939309) 1 NC_003317.1 hypothetical protein 939309 1196617 BMEI0906 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539823.1 938992 R 224914 CDS NP_539824.1 17987190 1196618 940518..940766 1 NC_003317.1 hypothetical protein 940766 1196618 BMEI0907 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539824.1 940518 D 224914 CDS NP_539825.1 17987191 1196619 complement(941252..942196) 1 NC_003317.1 serine protease 942196 1196619 BMEI0908 Brucella melitensis bv. 1 str. 16M serine protease NP_539825.1 941252 R 224914 CDS NP_539826.1 17987192 1196620 complement(942416..942835) 1 NC_003317.1 PR-AMP cyclohydrolase; functions in histidine biosynthesis from PRPP; converts 1-(5-phosphoribosyl)-AMP to 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxyamide during the histidine biosynthesis pathway; binds zinc and magnesium; forms homodimers; phosphoribosyl-AMP cyclohydrolase 942835 hisI 1196620 hisI Brucella melitensis bv. 1 str. 16M phosphoribosyl-AMP cyclohydrolase NP_539826.1 942416 R 224914 CDS NP_539827.1 17987193 1196621 complement(942858..943499) 1 NC_003317.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 943499 folE 1196621 folE Brucella melitensis bv. 1 str. 16M GTP cyclohydrolase I NP_539827.1 942858 R 224914 CDS NP_539828.1 17987194 1196622 943763..944203 1 NC_003317.1 NifU protein 944203 1196622 BMEI0911 Brucella melitensis bv. 1 str. 16M NifU protein NP_539828.1 943763 D 224914 CDS NP_539829.1 17987195 1196623 944205..944576 1 NC_003317.1 hypothetical protein 944576 1196623 BMEI0912 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539829.1 944205 D 224914 CDS NP_539830.1 17987196 1196624 944683..945300 1 NC_003317.1 penicillin-binding protein 6 (D-alanyl-D-alanine carboxypeptidase fraction C) 945300 1196624 BMEI0913 Brucella melitensis bv. 1 str. 16M penicillin-binding protein 6 (D-alanyl-D-alanine carboxypeptidase fraction C) NP_539830.1 944683 D 224914 CDS NP_539831.1 17987197 1196625 945367..945915 1 NC_003317.1 penicillin-binding protein 6 (D-alanyl-D-alanine carboxypeptidase fraction C) 945915 1196625 BMEI0914 Brucella melitensis bv. 1 str. 16M penicillin-binding protein 6 (D-alanyl-D-alanine carboxypeptidase fraction C) NP_539831.1 945367 D 224914 CDS NP_539832.1 17987198 1196626 946130..948106 1 NC_003317.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase 948106 thrS 1196626 thrS Brucella melitensis bv. 1 str. 16M threonyl-tRNA synthetase NP_539832.1 946130 D 224914 CDS NP_539833.1 17987199 1196627 complement(948161..949126) 1 NC_003317.1 hypothetical protein 949126 1196627 BMEI0916 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539833.1 948161 R 224914 CDS NP_539834.1 17987200 1196628 949391..949756 1 NC_003317.1 nitroreductase family protein 949756 1196628 BMEI0917 Brucella melitensis bv. 1 str. 16M nitroreductase family protein NP_539834.1 949391 D 224914 CDS NP_539835.1 17987201 1196629 949753..949974 1 NC_003317.1 nitroreductase family protein 949974 1196629 BMEI0918 Brucella melitensis bv. 1 str. 16M nitroreductase family protein NP_539835.1 949753 D 224914 CDS NP_539836.1 17987202 1196630 950017..950628 1 NC_003317.1 nitrilotriacetate monooxygenase component B 950628 1196630 BMEI0919 Brucella melitensis bv. 1 str. 16M nitrilotriacetate monooxygenase component B NP_539836.1 950017 D 224914 CDS NP_539837.1 17987203 1196631 complement(950637..951482) 1 NC_003317.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era; nucleoside triphosphate pyrophosphohydrolase 951482 mazG 1196631 mazG Brucella melitensis bv. 1 str. 16M nucleoside triphosphate pyrophosphohydrolase NP_539837.1 950637 R 224914 CDS NP_539838.1 17987204 1196632 951606..952613 1 NC_003317.1 UDP-glucose 4-epimerase 952613 1196632 BMEI0921 Brucella melitensis bv. 1 str. 16M UDP-glucose 4-epimerase NP_539838.1 951606 D 224914 CDS NP_539839.1 17987205 1196633 952742..953707 1 NC_003317.1 sodium/bile acid cotransporter family protein 953707 1196633 BMEI0922 Brucella melitensis bv. 1 str. 16M sodium/bile acid cotransporter family protein NP_539839.1 952742 D 224914 CDS NP_539840.1 17987206 1196634 953816..954646 1 NC_003317.1 3-demethylubiquinone-9 3-methyltransferase 954646 1196634 BMEI0923 Brucella melitensis bv. 1 str. 16M 3-demethylubiquinone-9 3-methyltransferase NP_539840.1 953816 D 224914 CDS NP_539841.1 17987207 1196635 954905..955900 1 NC_003317.1 Xaa-Pro dipeptidase 955900 1196635 BMEI0924 Brucella melitensis bv. 1 str. 16M Xaa-Pro dipeptidase NP_539841.1 954905 D 224914 CDS NP_539842.1 17987208 1196636 complement(956090..957073) 1 NC_003317.1 alcohol dehydrogenase 957073 1196636 BMEI0925 Brucella melitensis bv. 1 str. 16M alcohol dehydrogenase NP_539842.1 956090 R 224914 CDS NP_539843.1 17987209 1196637 957356..957958 1 NC_003317.1 multidrug resistance protein A 957958 1196637 BMEI0926 Brucella melitensis bv. 1 str. 16M multidrug resistance protein A NP_539843.1 957356 D 224914 CDS NP_539844.1 17987210 1196638 957910..959328 1 NC_003317.1 multidrug resistance protein B 959328 1196638 BMEI0927 Brucella melitensis bv. 1 str. 16M multidrug resistance protein B NP_539844.1 957910 D 224914 CDS NP_539845.1 17987211 1196639 959593..961083 1 NC_003317.1 acetate CoA-transferase subunit alpha 961083 1196639 BMEI0928 Brucella melitensis bv. 1 str. 16M acetate CoA-transferase subunit alpha NP_539845.1 959593 D 224914 CDS NP_539846.1 17987212 1196640 961675..962442 1 NC_003317.1 diguanylate cyclase/phosphodiesterase 962442 1196640 BMEI0929 Brucella melitensis bv. 1 str. 16M diguanylate cyclase/phosphodiesterase NP_539846.1 961675 D 224914 CDS NP_539847.1 17987213 1196641 complement(962481..962990) 1 NC_003317.1 acetyltransferase 962990 1196641 BMEI0930 Brucella melitensis bv. 1 str. 16M acetyltransferase NP_539847.1 962481 R 224914 CDS NP_539848.1 17987214 1196642 complement(963004..963858) 1 NC_003317.1 thiosulfate sulfurtransferase 963858 1196642 BMEI0931 Brucella melitensis bv. 1 str. 16M thiosulfate sulfurtransferase NP_539848.1 963004 R 224914 CDS NP_539849.1 17987215 1196643 complement(963885..964628) 1 NC_003317.1 alanyl-tRNA synthetase 964628 1196643 BMEI0932 Brucella melitensis bv. 1 str. 16M alanyl-tRNA synthetase NP_539849.1 963885 R 224914 CDS NP_539850.1 17987216 1196644 complement(964631..965659) 1 NC_003317.1 CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis; cysteine synthase A 965659 1196644 BMEI0933 Brucella melitensis bv. 1 str. 16M cysteine synthase A NP_539850.1 964631 R 224914 CDS NP_539851.1 17987217 1196645 complement(965830..967437) 1 NC_003317.1 ATP-dependent RNA helicase RHLE 967437 1196645 BMEI0934 Brucella melitensis bv. 1 str. 16M ATP-dependent RNA helicase RHLE NP_539851.1 965830 R 224914 CDS NP_539852.1 17987218 1196646 complement(967504..968763) 1 NC_003317.1 catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic; threonine dehydratase 968763 1196646 BMEI0935 Brucella melitensis bv. 1 str. 16M threonine dehydratase NP_539852.1 967504 R 224914 CDS NP_539853.1 17987219 1196647 complement(969065..969664) 1 NC_003317.1 stationary phase protein that binds TrpR repressor; TrpR binding protein WrbA 969664 1196647 BMEI0936 Brucella melitensis bv. 1 str. 16M TrpR binding protein WrbA NP_539853.1 969065 R 224914 CDS NP_539854.1 17987220 1196648 969825..970583 1 NC_003317.1 competence-damage protein 970583 1196648 BMEI0937 Brucella melitensis bv. 1 str. 16M competence-damage protein NP_539854.1 969825 D 224914 CDS NP_539855.1 17987221 1196649 970661..971506 1 NC_003317.1 universal stress protein UspA-like nucleotide-binding protein 971506 1196649 BMEI0938 Brucella melitensis bv. 1 str. 16M universal stress protein UspA-like nucleotide-binding protein NP_539855.1 970661 D 224914 CDS NP_539856.1 17987222 1196650 971733..971972 1 NC_003317.1 hypothetical protein 971972 1196650 BMEI0939 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539856.1 971733 D 224914 CDS NP_539857.1 17987223 1196651 971956..972468 1 NC_003317.1 catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively; xanthine-guanine phosphoribosyltransferase 972468 1196651 BMEI0940 Brucella melitensis bv. 1 str. 16M xanthine-guanine phosphoribosyltransferase NP_539857.1 971956 D 224914 CDS NP_539858.1 17987224 1196652 972695..973183 1 NC_003317.1 bis(5'-nucleosyl)-tetraphosphatase 973183 1196652 BMEI0941 Brucella melitensis bv. 1 str. 16M bis(5'-nucleosyl)-tetraphosphatase NP_539858.1 972695 D 224914 CDS NP_539859.1 17987225 1196653 complement(973593..973832) 1 NC_003317.1 hypothetical protein 973832 1196653 BMEI0942 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539859.1 973593 R 224914 CDS NP_539860.1 17987226 1196654 973894..977679 1 NC_003317.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 977679 1196654 BMEI0943 Brucella melitensis bv. 1 str. 16M ribonucleotide-diphosphate reductase subunit alpha NP_539860.1 973894 D 224914 CDS NP_539861.1 17987227 1196655 977769..978995 1 NC_003317.1 transport 978995 1196655 BMEI0944 Brucella melitensis bv. 1 str. 16M transport NP_539861.1 977769 D 224914 CDS NP_539862.1 17987228 1196656 complement(978976..979968) 1 NC_003317.1 6-aminohexanoate-dimer hydrolase 979968 1196656 BMEI0945 Brucella melitensis bv. 1 str. 16M 6-aminohexanoate-dimer hydrolase NP_539862.1 978976 R 224914 CDS NP_539863.1 17987229 1196657 complement(980332..981540) 1 NC_003317.1 NAD(FAD)-utilizing dehydrogenase 981540 1196657 BMEI0946 Brucella melitensis bv. 1 str. 16M NAD(FAD)-utilizing dehydrogenase NP_539863.1 980332 R 224914 CDS NP_539864.1 17987230 1196658 complement(981565..983868) 1 NC_003317.1 sensory transduction protein kinase 983868 1196658 BMEI0947 Brucella melitensis bv. 1 str. 16M sensory transduction protein kinase NP_539864.1 981565 R 224914 CDS NP_539865.1 17987231 1196659 984798..985883 1 NC_003317.1 hypothetical protein 985883 1196659 BMEI0948 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539865.1 984798 D 224914 CDS NP_539866.1 17987232 1196660 complement(986029..986445) 1 NC_003317.1 DNAK suppressor protein 986445 1196660 BMEI0949 Brucella melitensis bv. 1 str. 16M DNAK suppressor protein NP_539866.1 986029 R 224914 CDS NP_539867.1 17987233 1196661 986842..987342 1 NC_003317.1 phosphohistidine phosphatase SIXA 987342 1196661 BMEI0950 Brucella melitensis bv. 1 str. 16M phosphohistidine phosphatase SIXA NP_539867.1 986842 D 224914 CDS NP_539868.1 17987234 1196662 987435..988895 1 NC_003317.1 amino acid regulated cytosolic protein 988895 1196662 BMEI0951 Brucella melitensis bv. 1 str. 16M amino acid regulated cytosolic protein NP_539868.1 987435 D 224914 CDS NP_539869.1 17987235 1196663 988892..989965 1 NC_003317.1 hypothetical protein 989965 1196663 BMEI0952 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539869.1 988892 D 224914 CDS NP_539870.1 17987236 1196664 990304..990774 1 NC_003317.1 hypothetical protein 990774 1196664 BMEI0953 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539870.1 990304 D 224914 CDS NP_539871.1 17987237 1196665 complement(990889..991422) 1 NC_003317.1 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase 991422 1196665 BMEI0954 Brucella melitensis bv. 1 str. 16M 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase NP_539871.1 990889 R 224914 CDS NP_539872.1 17987238 1196666 complement(991419..991778) 1 NC_003317.1 dihydroneopterin aldolase 991778 1196666 BMEI0955 Brucella melitensis bv. 1 str. 16M dihydroneopterin aldolase NP_539872.1 991419 R 224914 CDS NP_539873.1 17987239 1196667 complement(991797..992636) 1 NC_003317.1 dihydropteroate synthase 992636 1196667 BMEI0956 Brucella melitensis bv. 1 str. 16M dihydropteroate synthase NP_539873.1 991797 R 224914 CDS NP_539874.1 17987240 1196668 992833..993414 1 NC_003317.1 hypothetical protein 993414 1196668 BMEI0957 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539874.1 992833 D 224914 CDS NP_539875.1 17987241 1196669 complement(993419..993760) 1 NC_003317.1 thioredoxin reductase 993760 1196669 BMEI0958 Brucella melitensis bv. 1 str. 16M thioredoxin reductase NP_539875.1 993419 R 224914 CDS NP_539876.1 17987242 1196670 complement(994060..994401) 1 NC_003317.1 (2Fe-2S)-binding protein 994401 1196670 BMEI0959 Brucella melitensis bv. 1 str. 16M (2Fe-2S)-binding protein NP_539876.1 994060 R 224914 CDS NP_539877.1 17987243 1196671 complement(994502..994783) 1 NC_003317.1 hypothetical protein 994783 1196671 BMEI0960 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539877.1 994502 R 224914 CDS NP_539878.1 17987244 1196672 995691..999671 1 NC_003317.1 kinesin-like protein 999671 1196672 BMEI0961 Brucella melitensis bv. 1 str. 16M kinesin-like protein NP_539878.1 995691 D 224914 CDS NP_539879.1 17987245 1196673 complement(999911..1000468) 1 NC_003317.1 membrane lipoprotein lipid attachment site containing protein 1000468 1196673 BMEI0962 Brucella melitensis bv. 1 str. 16M membrane lipoprotein lipid attachment site containing protein NP_539879.1 999911 R 224914 CDS NP_539880.1 17987246 1196674 complement(1000537..1001532) 1 NC_003317.1 toluene tolerance protein TTG2C 1001532 1196674 BMEI0963 Brucella melitensis bv. 1 str. 16M toluene tolerance protein TTG2C NP_539880.1 1000537 R 224914 CDS NP_539881.1 17987247 1196675 complement(1001536..1002399) 1 NC_003317.1 ABC transporter ATP-binding protein 1002399 1196675 BMEI0964 Brucella melitensis bv. 1 str. 16M ABC transporter ATP-binding protein NP_539881.1 1001536 R 224914 CDS NP_539882.1 17987248 1196676 complement(1002609..1003781) 1 NC_003317.1 toluene tolerance protein Ttg2B 1003781 1196676 BMEI0965 Brucella melitensis bv. 1 str. 16M toluene tolerance protein Ttg2B NP_539882.1 1002609 R 224914 CDS NP_539883.1 17987249 1196677 1003692..1004825 1 NC_003317.1 muconate cycloisomerase I 1004825 1196677 BMEI0966 Brucella melitensis bv. 1 str. 16M muconate cycloisomerase I NP_539883.1 1003692 D 224914 CDS NP_539884.1 17987250 1196678 1005043..1007367 1 NC_003317.1 NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; malic enzyme 1007367 1196678 BMEI0967 Brucella melitensis bv. 1 str. 16M malic enzyme NP_539884.1 1005043 D 224914 CDS NP_539885.1 17987251 1196679 complement(1008185..1009564) 1 NC_003317.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 1009564 gltX 1196679 gltX Brucella melitensis bv. 1 str. 16M glutamyl-tRNA synthetase NP_539885.1 1008185 R 224914 CDS NP_539886.1 17987252 1196680 complement(1009570..1011249) 1 NC_003317.1 NH(3)-dependent; catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase 1011249 nadE 1196680 nadE Brucella melitensis bv. 1 str. 16M NAD synthetase NP_539886.1 1009570 R 224914 CDS NP_539887.1 17987253 1196681 complement(1011314..1011694) 1 NC_003317.1 diacylglycerol kinase 1011694 1196681 BMEI0970 Brucella melitensis bv. 1 str. 16M diacylglycerol kinase NP_539887.1 1011314 R 224914 CDS NP_539888.1 17987254 1196682 complement(1011778..1013157) 1 NC_003317.1 phospho-2-dehydro-3-deoxyheptonate aldolase 1013157 1196682 BMEI0971 Brucella melitensis bv. 1 str. 16M phospho-2-dehydro-3-deoxyheptonate aldolase NP_539888.1 1011778 R 224914 CDS NP_539889.2 161511140 1196683 complement(1013366..1014760) 1 NC_003317.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase 1014760 1196683 BMEI0972 Brucella melitensis bv. 1 str. 16M glutathione reductase NP_539889.2 1013366 R 224914 CDS NP_539890.1 17987256 1196684 complement(1014914..1015384) 1 NC_003317.1 hypothetical protein 1015384 1196684 BMEI0973 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539890.1 1014914 R 224914 CDS NP_539891.1 17987257 1196685 complement(1015476..1016210) 1 NC_003317.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 1016210 1196685 BMEI0974 Brucella melitensis bv. 1 str. 16M ribose-5-phosphate isomerase A NP_539891.1 1015476 R 224914 CDS NP_539892.1 17987258 1196686 1016521..1017225 1 NC_003317.1 catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate; phosphoglycolate phosphatase 1017225 1196686 BMEI0975 Brucella melitensis bv. 1 str. 16M phosphoglycolate phosphatase NP_539892.1 1016521 D 224914 CDS NP_539893.1 17987259 1196687 1017222..1017494 1 NC_003317.1 hypothetical protein 1017494 1196687 BMEI0976 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539893.1 1017222 D 224914 CDS NP_539894.1 17987260 1196688 complement(1017525..1019093) 1 NC_003317.1 sugar kinase 1019093 1196688 BMEI0977 Brucella melitensis bv. 1 str. 16M sugar kinase NP_539894.1 1017525 R 224914 CDS NP_539895.1 17987261 1196689 1019337..1019675 1 NC_003317.1 nitrogen regulatory protein P-II 1019675 1196689 BMEI0978 Brucella melitensis bv. 1 str. 16M nitrogen regulatory protein P-II NP_539895.1 1019337 D 224914 CDS NP_539896.1 17987262 1196690 1019823..1021232 1 NC_003317.1 glutamine synthetase 1021232 1196690 BMEI0979 Brucella melitensis bv. 1 str. 16M glutamine synthetase NP_539896.1 1019823 D 224914 CDS NP_539897.1 17987263 1196691 complement(1021357..1022139) 1 NC_003317.1 hypothetical protein 1022139 1196691 BMEI0980 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539897.1 1021357 R 224914 CDS NP_539898.1 17987264 1196692 complement(1022181..1022831) 1 NC_003317.1 phosphoglycolate phosphatase 1022831 1196692 BMEI0981 Brucella melitensis bv. 1 str. 16M phosphoglycolate phosphatase NP_539898.1 1022181 R 224914 CDS NP_539899.1 17987265 1196693 complement(1022828..1023751) 1 NC_003317.1 transporter, DME family 1023751 1196693 BMEI0982 Brucella melitensis bv. 1 str. 16M transporter, DME family NP_539899.1 1022828 R 224914 CDS NP_539900.1 17987266 1196694 complement(1023754..1024785) 1 NC_003317.1 ribosomal large subunit pseudouridine synthase C 1024785 1196694 BMEI0983 Brucella melitensis bv. 1 str. 16M ribosomal large subunit pseudouridine synthase C NP_539900.1 1023754 R 224914 CDS NP_539901.1 17987267 1196695 1025047..1026846 1 NC_003317.1 responsible for transport of beta-1,2-glucans from the cytoplasm to periplasm; inner membrane ABC transporter permease component; Cgt; ChvA; NdvA; cyclic beta-1,2-glucan ABc transporter 1026846 1196695 BMEI0984 Brucella melitensis bv. 1 str. 16M cyclic beta-1,2-glucan ABc transporter NP_539901.1 1025047 D 224914 CDS NP_539902.1 17987268 1196696 complement(1026896..1027714) 1 NC_003317.1 PHNP protein 1027714 1196696 BMEI0985 Brucella melitensis bv. 1 str. 16M PHNP protein NP_539902.1 1026896 R 224914 CDS NP_539903.1 17987269 1196697 complement(1027717..1028514) 1 NC_003317.1 SEC-independent protein TATD 1028514 1196697 BMEI0986 Brucella melitensis bv. 1 str. 16M SEC-independent protein TATD NP_539903.1 1027717 R 224914 CDS NP_539904.1 17987270 1196698 complement(1028517..1030151) 1 NC_003317.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 1030151 metG 1196698 metG Brucella melitensis bv. 1 str. 16M methionyl-tRNA synthetase NP_539904.1 1028517 R 224914 CDS NP_539905.1 17987271 1196699 complement(1030220..1031302) 1 NC_003317.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' 1031302 1196699 BMEI0988 Brucella melitensis bv. 1 str. 16M DNA polymerase III subunit delta' NP_539905.1 1030220 R 224914 CDS NP_539906.1 17987272 1196700 complement(1031299..1031943) 1 NC_003317.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 1031943 1196700 BMEI0989 Brucella melitensis bv. 1 str. 16M thymidylate kinase NP_539906.1 1031299 R 224914 CDS NP_539907.1 17987273 1196701 complement(1032025..1033215) 1 NC_003317.1 D-alanyl-D-alanine carboxypeptidase 1033215 1196701 BMEI0990 Brucella melitensis bv. 1 str. 16M D-alanyl-D-alanine carboxypeptidase NP_539907.1 1032025 R 224914 CDS NP_539908.1 17987274 1196702 complement(1033326..1034501) 1 NC_003317.1 rare lipoprotein A 1034501 1196702 BMEI0991 Brucella melitensis bv. 1 str. 16M rare lipoprotein A NP_539908.1 1033326 R 224914 CDS NP_539909.1 17987275 1196703 complement(1034962..1035309) 1 NC_003317.1 arsenate reductase 1035309 1196703 BMEI0992 Brucella melitensis bv. 1 str. 16M arsenate reductase NP_539909.1 1034962 R 224914 CDS NP_539910.1 17987276 1196704 1035296..1035550 1 NC_003317.1 hypothetical protein 1035550 1196704 BMEI0993 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539910.1 1035296 D 224914 CDS NP_539911.1 17987277 1196705 complement(1035649..1035909) 1 NC_003317.1 hypothetical protein 1035909 1196705 BMEI0994 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539911.1 1035649 R 224914 CDS NP_539912.1 17987278 1196706 complement(1036269..1037027) 1 NC_003317.1 secretion activator protein 1037027 1196706 BMEI0995 Brucella melitensis bv. 1 str. 16M secretion activator protein NP_539912.1 1036269 R 224914 CDS NP_539913.1 17987279 1196707 1037172..1037393 1 NC_003317.1 hypothetical protein 1037393 1196707 BMEI0996 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539913.1 1037172 D 224914 CDS NP_539914.1 17987280 1196708 complement(1037374..1038933) 1 NC_003317.1 mannosyltransferase 1038933 1196708 BMEI0997 Brucella melitensis bv. 1 str. 16M mannosyltransferase NP_539914.1 1037374 R 224914 CDS NP_539915.1 17987281 1196709 complement(1038930..1040162) 1 NC_003317.1 glycosyltransferase 1040162 1196709 BMEI0998 Brucella melitensis bv. 1 str. 16M glycosyltransferase NP_539915.1 1038930 R 224914 CDS NP_539916.1 17987282 1196710 complement(1040488..1041939) 1 NC_003317.1 hypothetical protein 1041939 1196710 BMEI0999 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539916.1 1040488 R 224914 CDS NP_539917.1 17987283 1196711 complement(1042270..1043007) 1 NC_003317.1 hypothetical protein 1043007 1196711 BMEI1000 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539917.1 1042270 R 224914 CDS NP_539918.1 17987284 1196712 complement(1043044..1043436) 1 NC_003317.1 transposase 1043436 1196712 BMEI1001 Brucella melitensis bv. 1 str. 16M transposase NP_539918.1 1043044 R 224914 CDS NP_539919.1 17987285 1196713 complement(1043433..1043801) 1 NC_003317.1 transposase 1043801 1196713 BMEI1002 Brucella melitensis bv. 1 str. 16M transposase NP_539919.1 1043433 R 224914 CDS NP_539920.1 17987286 1196714 complement(1043871..1044479) 1 NC_003317.1 queuine tRNA-ribosyltransferase 1044479 1196714 BMEI1003 Brucella melitensis bv. 1 str. 16M queuine tRNA-ribosyltransferase NP_539920.1 1043871 R 224914 CDS NP_539921.1 17987287 1196715 1044642..1044887 1 NC_003317.1 hypothetical protein 1044887 1196715 BMEI1004 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539921.1 1044642 D 224914 CDS NP_539922.1 17987288 1196716 complement(1045317..1045526) 1 NC_003317.1 hypothetical protein 1045526 1196716 BMEI1005 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539922.1 1045317 R 224914 CDS NP_539923.1 17987289 1196717 1045549..1045719 1 NC_003317.1 hypothetical protein 1045719 1196717 BMEI1006 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539923.1 1045549 D 224914 CDS NP_539924.1 17987290 1196718 complement(1046067..1046777) 1 NC_003317.1 hypothetical protein 1046777 1196718 BMEI1007 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539924.1 1046067 R 224914 CDS NP_539925.1 17987291 1196719 complement(1047012..1047530) 1 NC_003317.1 hypothetical protein 1047530 1196719 BMEI1008 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539925.1 1047012 R 224914 CDS NP_539926.1 17987292 1196720 complement(1047622..1047897) 1 NC_003317.1 hypothetical protein 1047897 1196720 BMEI1009 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539926.1 1047622 R 224914 CDS NP_539927.1 17987293 1196721 complement(1048121..1049038) 1 NC_003317.1 hypothetical protein 1049038 1196721 BMEI1010 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539927.1 1048121 R 224914 CDS NP_539928.1 17987294 1196722 1048875..1049078 1 NC_003317.1 hypothetical protein 1049078 1196722 BMEI1011 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539928.1 1048875 D 224914 CDS NP_539929.1 17987295 1196723 1049498..1050508 1 NC_003317.1 integrase/recombinase 1050508 1196723 BMEI1012 Brucella melitensis bv. 1 str. 16M integrase/recombinase NP_539929.1 1049498 D 224914 CDS NP_539930.1 17987296 1196724 1051017..1051268 1 NC_003317.1 hypothetical protein 1051268 1196724 BMEI1013 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539930.1 1051017 D 224914 CDS NP_539931.1 17987297 1196725 complement(1052069..1053664) 1 NC_003317.1 cell wall degradation protein 1053664 1196725 BMEI1014 Brucella melitensis bv. 1 str. 16M cell wall degradation protein NP_539931.1 1052069 R 224914 CDS NP_539932.1 17987298 1196726 complement(1053686..1053973) 1 NC_003317.1 hypothetical protein 1053973 1196726 BMEI1015 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539932.1 1053686 R 224914 CDS NP_539933.1 17987299 1196727 1054379..1055998 1 NC_003317.1 class I fumarate hydratase 1055998 1196727 BMEI1016 Brucella melitensis bv. 1 str. 16M class I fumarate hydratase NP_539933.1 1054379 D 224914 CDS NP_539934.1 17987300 1196728 1056319..1057452 1 NC_003317.1 salicylate hydroxylase 1057452 1196728 BMEI1017 Brucella melitensis bv. 1 str. 16M salicylate hydroxylase NP_539934.1 1056319 D 224914 CDS NP_539935.1 17987301 1196729 complement(1057520..1057879) 1 NC_003317.1 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase 1057879 1196729 BMEI1018 Brucella melitensis bv. 1 str. 16M phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase NP_539935.1 1057520 R 224914 CDS NP_539936.1 17987302 1196730 1058066..1059100 1 NC_003317.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z; molybdenum cofactor biosynthesis protein A 1059100 moaA 1196730 moaA Brucella melitensis bv. 1 str. 16M molybdenum cofactor biosynthesis protein A NP_539936.1 1058066 D 224914 CDS NP_539937.1 17987303 1196731 1059276..1059941 1 NC_003317.1 molybdopterin-guanine dinucleotide biosynthesis protein MobA 1059941 1196731 BMEI1020 Brucella melitensis bv. 1 str. 16M molybdopterin-guanine dinucleotide biosynthesis protein MobA NP_539937.1 1059276 D 224914 CDS NP_539938.1 17987304 1196732 1059938..1060336 1 NC_003317.1 molybdopterin-guanine dinucleotide biosynthesis protein MobB 1060336 1196732 BMEI1021 Brucella melitensis bv. 1 str. 16M molybdopterin-guanine dinucleotide biosynthesis protein MobB NP_539938.1 1059938 D 224914 CDS NP_539939.1 17987305 1196733 1060785..1061231 1 NC_003317.1 arginine/ornithine-binding periplasmic protein precursor 1061231 1196733 BMEI1022 Brucella melitensis bv. 1 str. 16M arginine/ornithine-binding periplasmic protein precursor NP_539939.1 1060785 D 224914 CDS NP_539940.1 17987306 1196734 1061203..1061532 1 NC_003317.1 glutathione S-transferase 1061532 1196734 BMEI1023 Brucella melitensis bv. 1 str. 16M glutathione S-transferase NP_539940.1 1061203 D 224914 CDS NP_539941.1 17987307 1196735 1061560..1062435 1 NC_003317.1 3-hydroxyisobutyrate dehydrogenase 1062435 1196735 BMEI1024 Brucella melitensis bv. 1 str. 16M 3-hydroxyisobutyrate dehydrogenase NP_539941.1 1061560 D 224914 CDS NP_539942.1 17987308 1196736 complement(1062501..1063391) 1 NC_003317.1 outer membrane protein E 1063391 1196736 BMEI1025 Brucella melitensis bv. 1 str. 16M outer membrane protein E NP_539942.1 1062501 R 224914 CDS NP_539943.1 17987309 1196737 complement(1063500..1063787) 1 NC_003317.1 outer membrane protein E 1063787 1196737 BMEI1026 Brucella melitensis bv. 1 str. 16M outer membrane protein E NP_539943.1 1063500 R 224914 CDS NP_539944.1 17987310 1196738 complement(1064193..1066925) 1 NC_003317.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 1066925 valS 1196738 valS Brucella melitensis bv. 1 str. 16M valyl-tRNA synthetase NP_539944.1 1064193 R 224914 CDS NP_539945.1 17987311 1196739 complement(1067216..1067911) 1 NC_003317.1 hypothetical protein 1067911 1196739 BMEI1028 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539945.1 1067216 R 224914 CDS NP_539946.1 17987312 1196740 complement(1068197..1069567) 1 NC_003317.1 outer membrane protein TolC 1069567 1196740 BMEI1029 Brucella melitensis bv. 1 str. 16M outer membrane protein TolC NP_539946.1 1068197 R 224914 CDS NP_539947.1 17987313 1196741 complement(1069706..1070374) 1 NC_003317.1 protein-L-isoaspartate O-methyltransferase 1070374 1196741 BMEI1030 Brucella melitensis bv. 1 str. 16M protein-L-isoaspartate O-methyltransferase NP_539947.1 1069706 R 224914 CDS NP_539948.1 17987314 1196742 complement(1070368..1070550) 1 NC_003317.1 hypothetical protein 1070550 1196742 BMEI1031 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539948.1 1070368 R 224914 CDS NP_539949.1 17987315 1196743 complement(1070703..1070900) 1 NC_003317.1 heavy metal binding protein 1070900 1196743 BMEI1032 Brucella melitensis bv. 1 str. 16M heavy metal binding protein NP_539949.1 1070703 R 224914 CDS NP_539950.1 17987316 1196744 complement(1070984..1071607) 1 NC_003317.1 hypothetical protein 1071607 1196744 BMEI1033 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539950.1 1070984 R 224914 CDS NP_539951.1 17987317 1196745 1071737..1072180 1 NC_003317.1 HESB protein 1072180 1196745 BMEI1034 Brucella melitensis bv. 1 str. 16M HESB protein NP_539951.1 1071737 D 224914 CDS NP_539952.1 17987318 1196746 complement(1072417..1073865) 1 NC_003317.1 ATP-dependent RNA helicase DeaD 1073865 1196746 BMEI1035 Brucella melitensis bv. 1 str. 16M ATP-dependent RNA helicase DeaD NP_539952.1 1072417 R 224914 CDS NP_539953.1 17987319 1196747 complement(1074193..1074990) 1 NC_003317.1 catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 1074990 ppnK 1196747 ppnK Brucella melitensis bv. 1 str. 16M inorganic polyphosphate/ATP-NAD kinase NP_539953.1 1074193 R 224914 CDS NP_539954.1 17987320 1196748 1075393..1076364 1 NC_003317.1 cell wall biosynthesis glycosyltransferase 1076364 1196748 BMEI1037 Brucella melitensis bv. 1 str. 16M cell wall biosynthesis glycosyltransferase NP_539954.1 1075393 D 224914 CDS NP_539955.1 17987321 1196749 complement(1076398..1076808) 1 NC_003317.1 phenylacetic acid degradation protein PAAD 1076808 1196749 BMEI1038 Brucella melitensis bv. 1 str. 16M phenylacetic acid degradation protein PAAD NP_539955.1 1076398 R 224914 CDS NP_539956.1 17987322 1196750 complement(1076814..1078124) 1 NC_003317.1 cysteine desulfhydrase 1078124 1196750 BMEI1039 Brucella melitensis bv. 1 str. 16M cysteine desulfhydrase NP_539956.1 1076814 R 224914 CDS NP_539957.1 17987323 1196751 complement(1078140..1079417) 1 NC_003317.1 ABC transporter ATP-binding protein 1079417 1196751 BMEI1040 Brucella melitensis bv. 1 str. 16M ABC transporter ATP-binding protein NP_539957.1 1078140 R 224914 CDS NP_539958.1 17987324 1196752 complement(1079431..1080273) 1 NC_003317.1 ABC transporter ATP-binding protein 1080273 1196752 BMEI1041 Brucella melitensis bv. 1 str. 16M ABC transporter ATP-binding protein NP_539958.1 1079431 R 224914 CDS NP_539959.1 17987325 1196753 complement(1080254..1081777) 1 NC_003317.1 with SufCD activates cysteine desulfurase SufS; cysteine desulfurase 1081777 1196753 BMEI1042 Brucella melitensis bv. 1 str. 16M cysteine desulfurase NP_539959.1 1080254 R 224914 CDS NP_539960.1 17987326 1196754 complement(1081958..1083136) 1 NC_003317.1 NifS protein 1083136 1196754 BMEI1043 Brucella melitensis bv. 1 str. 16M NifS protein NP_539960.1 1081958 R 224914 CDS NP_539961.1 17987327 1196755 1083341..1084015 1 NC_003317.1 alpha/beta hydrolase 1084015 1196755 BMEI1044 Brucella melitensis bv. 1 str. 16M alpha/beta hydrolase NP_539961.1 1083341 D 224914 CDS NP_539962.1 17987328 1196756 1084127..1084459 1 NC_003317.1 quaternary ammonium compound-resistance protein QACE 1084459 1196756 BMEI1045 Brucella melitensis bv. 1 str. 16M quaternary ammonium compound-resistance protein QACE NP_539962.1 1084127 D 224914 CDS NP_539963.1 17987329 1196757 complement(1084456..1085577) 1 NC_003317.1 catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling; anhydro-N-acetylmuramic acid kinase 1085577 anmK 1196757 anmK Brucella melitensis bv. 1 str. 16M anhydro-N-acetylmuramic acid kinase NP_539963.1 1084456 R 224914 CDS NP_539964.1 17987330 1196758 1085693..1086946 1 NC_003317.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 1086946 1196758 BMEI1047 Brucella melitensis bv. 1 str. 16M tyrosyl-tRNA synthetase NP_539964.1 1085693 D 224914 CDS NP_539965.1 17987331 1196759 complement(1087006..1089519) 1 NC_003317.1 hypothetical protein 1089519 1196759 BMEI1048 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539965.1 1087006 R 224914 CDS NP_539966.1 17987332 1196760 1090691..1091155 1 NC_003317.1 bacterioferritin comigratory protein 1091155 1196760 BMEI1049 Brucella melitensis bv. 1 str. 16M bacterioferritin comigratory protein NP_539966.1 1090691 D 224914 CDS NP_539967.1 17987333 1196761 1091177..1092004 1 NC_003317.1 hypothetical protein 1092004 1196761 BMEI1050 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539967.1 1091177 D 224914 CDS NP_539968.1 17987334 1196762 1092196..1092537 1 NC_003317.1 hypothetical protein 1092537 1196762 BMEI1051 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539968.1 1092196 D 224914 CDS NP_539969.1 17987335 1196763 complement(1092804..1093082) 1 NC_003317.1 transposase 1093082 1196763 BMEI1052 Brucella melitensis bv. 1 str. 16M transposase NP_539969.1 1092804 R 224914 CDS NP_539970.1 17987336 1196764 complement(1093079..1093447) 1 NC_003317.1 transposase 1093447 1196764 BMEI1053 Brucella melitensis bv. 1 str. 16M transposase NP_539970.1 1093079 R 224914 CDS NP_539971.1 17987337 1196765 complement(1093641..1094606) 1 NC_003317.1 catalyzes the release of newly synthesized polypeptide chains at the stop codons UAA and UGA; peptide chain release factor 2 1094606 1196765 BMEI1054 Brucella melitensis bv. 1 str. 16M peptide chain release factor 2 NP_539971.1 1093641 R 224914 CDS NP_539972.1 17987338 1196766 complement(1094910..1097369) 1 NC_003317.1 penicillin-binding protein 1A 1097369 1196766 BMEI1055 Brucella melitensis bv. 1 str. 16M penicillin-binding protein 1A NP_539972.1 1094910 R 224914 CDS NP_539973.1 17987339 1196767 complement(1097649..1098821) 1 NC_003317.1 N-acetylmuramoyl-L-alanine amidase 1098821 1196767 BMEI1056 Brucella melitensis bv. 1 str. 16M N-acetylmuramoyl-L-alanine amidase NP_539973.1 1097649 R 224914 CDS NP_539974.1 17987340 1196768 1099596..1102271 1 NC_003317.1 ribonuclease E / zinc metalloprotease 1102271 1196768 BMEI1057 Brucella melitensis bv. 1 str. 16M ribonuclease E / zinc metalloprotease NP_539974.1 1099596 D 224914 CDS NP_539975.1 17987341 1196769 complement(1102568..1103638) 1 NC_003317.1 aspartate aminotransferase 1103638 1196769 BMEI1058 Brucella melitensis bv. 1 str. 16M aspartate aminotransferase NP_539975.1 1102568 R 224914 CDS NP_539976.1 17987342 1196770 1103746..1105161 1 NC_003317.1 zinc metalloprotease 1105161 1196770 BMEI1059 Brucella melitensis bv. 1 str. 16M zinc metalloprotease NP_539976.1 1103746 D 224914 CDS NP_539977.1 17987343 1196771 1105254..1106006 1 NC_003317.1 hypothetical protein 1106006 1196771 BMEI1060 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539977.1 1105254 D 224914 CDS NP_539978.1 17987344 1196772 1106220..1106723 1 NC_003317.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis; 3-dehydroquinate dehydratase 1106723 1196772 BMEI1061 Brucella melitensis bv. 1 str. 16M 3-dehydroquinate dehydratase NP_539978.1 1106220 D 224914 CDS NP_539979.1 17987345 1196773 1106725..1107195 1 NC_003317.1 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 1107195 1196773 BMEI1062 Brucella melitensis bv. 1 str. 16M acetyl-CoA carboxylase biotin carboxyl carrier protein subunit NP_539979.1 1106725 D 224914 CDS NP_539980.2 161511139 1196774 1107245..1108603 1 NC_003317.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit 1108603 1196774 BMEI1063 Brucella melitensis bv. 1 str. 16M acetyl-CoA carboxylase biotin carboxylase subunit NP_539980.2 1107245 D 224914 CDS NP_539981.1 17987347 1196775 1108609..1109223 1 NC_003317.1 leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys; leucyl/phenylalanyl-tRNA--protein transferase 1109223 aat 1196775 aat Brucella melitensis bv. 1 str. 16M leucyl/phenylalanyl-tRNA--protein transferase NP_539981.1 1108609 D 224914 CDS NP_539982.1 17987348 1196776 complement(1109267..1109722) 1 NC_003317.1 hypothetical protein 1109722 1196776 BMEI1065 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539982.1 1109267 R 224914 CDS NP_539983.1 17987349 1196777 complement(1109931..1110341) 1 NC_003317.1 Provides the input to the respiratory chain from the NAD-linked dehydrogenases of the citric acid cycle. The complex couples the oxidation of NADH and the reduction of ubiquinone, to the generation of a proton gradient which is then used for ATP synthesis; NADH dehydrogenase 1110341 1196777 BMEI1066 Brucella melitensis bv. 1 str. 16M NADH dehydrogenase NP_539983.1 1109931 R 224914 CDS NP_539984.1 17987350 1196778 complement(1110501..1111004) 1 NC_003317.1 acetyltransferase 1111004 1196778 BMEI1067 Brucella melitensis bv. 1 str. 16M acetyltransferase NP_539984.1 1110501 R 224914 CDS NP_539985.1 17987351 1196779 complement(1111004..1112506) 1 NC_003317.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B 1112506 gatB 1196779 gatB Brucella melitensis bv. 1 str. 16M aspartyl/glutamyl-tRNA amidotransferase subunit B NP_539985.1 1111004 R 224914 CDS NP_539986.1 17987352 1196780 complement(1112656..1114113) 1 NC_003317.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 1114113 tig 1196780 tig Brucella melitensis bv. 1 str. 16M trigger factor NP_539986.1 1112656 R 224914 CDS NP_539987.1 17987353 1196781 complement(1114493..1115062) 1 NC_003317.1 hypothetical protein 1115062 1196781 BMEI1070 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539987.1 1114493 R 224914 CDS NP_539988.1 17987354 1196782 complement(1115059..1116063) 1 NC_003317.1 hypothetical protein 1116063 1196782 BMEI1071 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539988.1 1115059 R 224914 CDS NP_539989.1 17987355 1196783 1116469..1116615 1 NC_003317.1 hypothetical protein 1116615 1196783 BMEI1072 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539989.1 1116469 D 224914 CDS NP_539990.1 17987356 1196784 1116821..1118257 1 NC_003317.1 TrmFO; Gid; glucose-inhibited division protein; similar to GidA; the gene from Bacillus subtilis encodes a tRNA-methyltransferase that utilizes folate as the carbon donor and bound flavin as reductant; modifies tRNA at position 54 (uridine) of the T-psi loop to form a C5-methyluridine; tRNA (uracil-5-)-methyltransferase Gid 1118257 1196784 BMEI1073 Brucella melitensis bv. 1 str. 16M tRNA (uracil-5-)-methyltransferase Gid NP_539990.1 1116821 D 224914 CDS NP_539991.1 17987357 1196785 complement(1118309..1119142) 1 NC_003317.1 phytoene synthase 1119142 1196785 BMEI1074 Brucella melitensis bv. 1 str. 16M phytoene synthase NP_539991.1 1118309 R 224914 CDS NP_539992.1 17987358 1196786 complement(1119148..1119537) 1 NC_003317.1 hypothetical protein 1119537 1196786 BMEI1075 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539992.1 1119148 R 224914 CDS NP_539993.1 17987359 1196787 complement(1119540..1121867) 1 NC_003317.1 part of the preprotein secretory system; forms a complex with protein YajC; SecDFyajC stimulates the proton motive force-driven protein translocation, seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecD/SecF 1121867 1196787 BMEI1076 Brucella melitensis bv. 1 str. 16M preprotein translocase subunit SecD/SecF NP_539993.1 1119540 R 224914 CDS NP_539994.1 17987360 1196788 complement(1121987..1122349) 1 NC_003317.1 hypothetical protein 1122349 1196788 BMEI1077 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_539994.1 1121987 R 224914 CDS NP_539995.1 17987361 1196789 1122452..1123354 1 NC_003317.1 ATP-dependent protease subunit 1123354 1196789 BMEI1078 Brucella melitensis bv. 1 str. 16M ATP-dependent protease subunit NP_539995.1 1122452 D 224914 CDS NP_539996.1 17987362 1196790 complement(1123403..1124686) 1 NC_003317.1 lipoprotein NlpD 1124686 1196790 BMEI1079 Brucella melitensis bv. 1 str. 16M lipoprotein NlpD NP_539996.1 1123403 R 224914 CDS NP_539997.1 17987363 1196791 complement(1125080..1125748) 1 NC_003317.1 catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins; protein-L-isoaspartate O-methyltransferase 1125748 pcm 1196791 pcm Brucella melitensis bv. 1 str. 16M protein-L-isoaspartate O-methyltransferase NP_539997.1 1125080 R 224914 CDS NP_539998.1 17987364 1196792 complement(1125745..1126545) 1 NC_003317.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate; stationary phase survival protein SurE 1126545 surE 1196792 surE Brucella melitensis bv. 1 str. 16M stationary phase survival protein SurE NP_539998.1 1125745 R 224914 CDS NP_539999.2 161511138 1196793 complement(1126661..1127944) 1 NC_003317.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 1127944 1196793 BMEI1082 Brucella melitensis bv. 1 str. 16M seryl-tRNA synthetase NP_539999.2 1126661 R 224914 CDS NP_540000.1 17987366 1196794 complement(1128021..1128845) 1 NC_003317.1 SEC-independent protein translocase protein TATC 1128845 1196794 BMEI1083 Brucella melitensis bv. 1 str. 16M SEC-independent protein translocase protein TATC NP_540000.1 1128021 R 224914 CDS NP_540001.1 17987367 1196795 complement(1129534..1129752) 1 NC_003317.1 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin-arginine translocation protein TatA 1129752 tatA 1196795 tatA Brucella melitensis bv. 1 str. 16M twin-arginine translocation protein TatA NP_540001.1 1129534 R 224914 CDS NP_540002.1 17987368 1196796 complement(1129898..1130590) 1 NC_003317.1 hypothetical protein 1130590 1196796 BMEI1085 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540002.1 1129898 R 224914 CDS NP_540003.1 17987369 1196797 complement(1130616..1131467) 1 NC_003317.1 hypothetical protein 1131467 1196797 BMEI1086 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540003.1 1130616 R 224914 CDS NP_540004.1 17987370 1196798 complement(1131540..1132592) 1 NC_003317.1 beta-hexosaminidase A 1132592 1196798 BMEI1087 Brucella melitensis bv. 1 str. 16M beta-hexosaminidase A NP_540004.1 1131540 R 224914 CDS NP_540005.1 17987371 1196799 complement(1132760..1135669) 1 NC_003317.1 soluble lytic murein transglycosylase 1135669 1196799 BMEI1088 Brucella melitensis bv. 1 str. 16M soluble lytic murein transglycosylase NP_540005.1 1132760 R 224914 CDS NP_540006.1 17987372 1196800 complement(1135926..1137683) 1 NC_003317.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1137683 argS 1196800 argS Brucella melitensis bv. 1 str. 16M arginyl-tRNA synthetase NP_540006.1 1135926 R 224914 CDS NP_540007.1 17987373 1196801 complement(1137905..1139113) 1 NC_003317.1 dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate; deoxyguanosinetriphosphate triphosphohydrolase-like protein 1139113 1196801 BMEI1090 Brucella melitensis bv. 1 str. 16M deoxyguanosinetriphosphate triphosphohydrolase-like protein NP_540007.1 1137905 R 224914 CDS NP_540008.1 17987374 1196802 1139280..1139606 1 NC_003317.1 HESB protein 1139606 1196802 BMEI1091 Brucella melitensis bv. 1 str. 16M HESB protein NP_540008.1 1139280 D 224914 CDS NP_540009.1 17987375 1196803 complement(1139687..1140178) 1 NC_003317.1 hypothetical protein 1140178 1196803 BMEI1092 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540009.1 1139687 R 224914 CDS NP_540010.1 17987376 1196804 1140455..1141345 1 NC_003317.1 exodeoxyribonuclease III 1141345 1196804 BMEI1093 Brucella melitensis bv. 1 str. 16M exodeoxyribonuclease III NP_540010.1 1140455 D 224914 CDS NP_540011.1 17987377 1196805 complement(1141404..1142207) 1 NC_003317.1 exopolysaccharide production negative regulator 1142207 1196805 BMEI1094 Brucella melitensis bv. 1 str. 16M exopolysaccharide production negative regulator NP_540011.1 1141404 R 224914 CDS NP_540012.1 17987378 1196806 complement(1142579..1142857) 1 NC_003317.1 hypothetical protein 1142857 1196806 BMEI1095 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540012.1 1142579 R 224914 CDS NP_540013.1 17987379 1196807 1142939..1143397 1 NC_003317.1 succinoglycan biosynthesis protein EXOI 1143397 1196807 BMEI1096 Brucella melitensis bv. 1 str. 16M succinoglycan biosynthesis protein EXOI NP_540013.1 1142939 D 224914 CDS NP_540014.1 17987380 1196808 1143494..1144135 1 NC_003317.1 uracil-DNA glycosylase 1144135 1196808 BMEI1097 Brucella melitensis bv. 1 str. 16M uracil-DNA glycosylase NP_540014.1 1143494 D 224914 CDS NP_540015.1 17987381 1196809 1144264..1144743 1 NC_003317.1 AsnC family transcriptional regulator 1144743 1196809 BMEI1098 Brucella melitensis bv. 1 str. 16M AsnC family transcriptional regulator NP_540015.1 1144264 D 224914 CDS NP_540016.1 17987382 1196810 complement(1144851..1145870) 1 NC_003317.1 catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 1145870 cobT 1196810 cobT Brucella melitensis bv. 1 str. 16M nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase NP_540016.1 1144851 R 224914 CDS NP_540017.1 17987383 1196811 1146024..1146806 1 NC_003317.1 catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole; cobalamin synthase 1146806 cobS 1196811 cobS Brucella melitensis bv. 1 str. 16M cobalamin synthase NP_540017.1 1146024 D 224914 CDS NP_540018.1 17987384 1196812 1146790..1147020 1 NC_003317.1 hypothetical protein 1147020 1196812 BMEI1101 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540018.1 1146790 D 224914 CDS NP_540019.1 17987385 1196813 1147077..1147724 1 NC_003317.1 transporter 1147724 1196813 BMEI1102 Brucella melitensis bv. 1 str. 16M transporter NP_540019.1 1147077 D 224914 CDS NP_540020.1 17987386 1196814 complement(1147721..1148743) 1 NC_003317.1 tRNA-dihydrouridine synthase A 1148743 1196814 BMEI1103 Brucella melitensis bv. 1 str. 16M tRNA-dihydrouridine synthase A NP_540020.1 1147721 R 224914 CDS NP_540021.1 17987387 1196815 complement(1148935..1149690) 1 NC_003317.1 arginine/ornithine-binding periplasmic protein precursor 1149690 1196815 BMEI1104 Brucella melitensis bv. 1 str. 16M arginine/ornithine-binding periplasmic protein precursor NP_540021.1 1148935 R 224914 CDS NP_540022.1 17987388 1196816 1149980..1150663 1 NC_003317.1 glycerol-3-phosphatase 1 1150663 1196816 BMEI1105 Brucella melitensis bv. 1 str. 16M glycerol-3-phosphatase 1 NP_540022.1 1149980 D 224914 CDS NP_540023.1 17987389 1196817 complement(1150660..1151799) 1 NC_003317.1 PhnM protein 1151799 1196817 BMEI1106 Brucella melitensis bv. 1 str. 16M PhnM protein NP_540023.1 1150660 R 224914 CDS NP_540024.1 17987390 1196818 complement(1151803..1152534) 1 NC_003317.1 hypothetical protein 1152534 1196818 BMEI1107 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540024.1 1151803 R 224914 CDS NP_540025.1 17987391 1196819 1152723..1153640 1 NC_003317.1 2-dehydro-3-deoxygluconokinase 1153640 1196819 BMEI1108 Brucella melitensis bv. 1 str. 16M 2-dehydro-3-deoxygluconokinase NP_540025.1 1152723 D 224914 CDS NP_540026.1 17987392 1196820 complement(1153637..1154659) 1 NC_003317.1 aldose 1-epimerase 1154659 1196820 BMEI1109 Brucella melitensis bv. 1 str. 16M aldose 1-epimerase NP_540026.1 1153637 R 224914 CDS NP_540027.1 17987393 1196821 1154875..1155636 1 NC_003317.1 secretion activator protein 1155636 1196821 BMEI1110 Brucella melitensis bv. 1 str. 16M secretion activator protein NP_540027.1 1154875 D 224914 CDS NP_540028.1 17987394 1196822 1155837..1156118 1 NC_003317.1 Involved in the biosynthetic pathways of fatty acids, phospholipids, lipopolysaccharides, and oligosaccharides; acyl carrier protein 1156118 1196822 BMEI1111 Brucella melitensis bv. 1 str. 16M acyl carrier protein NP_540028.1 1155837 D 224914 CDS NP_540029.1 17987395 1196823 1156266..1157447 1 NC_003317.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 1157447 1196823 BMEI1112 Brucella melitensis bv. 1 str. 16M 3-oxoacyl-ACP synthase NP_540029.1 1156266 D 224914 CDS NP_540030.1 17987396 1196824 1157449..1158726 1 NC_003317.1 FabF, beta-Ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP.; 3-oxoacyl-ACP synthase 1158726 1196824 BMEI1113 Brucella melitensis bv. 1 str. 16M 3-oxoacyl-ACP synthase NP_540030.1 1157449 D 224914 CDS NP_540031.1 17987397 1196825 1158808..1159836 1 NC_003317.1 alcohol dehydrogenase 1159836 1196825 BMEI1114 Brucella melitensis bv. 1 str. 16M alcohol dehydrogenase NP_540031.1 1158808 D 224914 CDS NP_540032.1 17987398 1196826 1159853..1160776 1 NC_003317.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase 1160776 1196826 BMEI1115 Brucella melitensis bv. 1 str. 16M lipid A biosynthesis lauroyl acyltransferase NP_540032.1 1159853 D 224914 CDS NP_540033.1 17987399 1196827 1160793..1161611 1 NC_003317.1 ribulose-phosphate 3-epimerase 1161611 1196827 BMEI1116 Brucella melitensis bv. 1 str. 16M ribulose-phosphate 3-epimerase NP_540033.1 1160793 D 224914 CDS NP_540034.1 17987400 1196828 1161638..1162939 1 NC_003317.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 1162939 1196828 BMEI1117 Brucella melitensis bv. 1 str. 16M adenylosuccinate lyase NP_540034.1 1161638 D 224914 CDS NP_540035.1 17987401 1196829 complement(1163165..1164040) 1 NC_003317.1 biphenyl-2,3-diol 1,2-dioxygenase III 1164040 1196829 BMEI1118 Brucella melitensis bv. 1 str. 16M biphenyl-2,3-diol 1,2-dioxygenase III NP_540035.1 1163165 R 224914 CDS NP_540036.1 17987402 1196830 1164309..1164875 1 NC_003317.1 hypothetical protein 1164875 1196830 BMEI1119 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540036.1 1164309 D 224914 CDS NP_540037.1 17987403 1196831 complement(1164924..1165679) 1 NC_003317.1 phosphotyrosyl phosphatase activator (PTPA) 1165679 1196831 BMEI1120 Brucella melitensis bv. 1 str. 16M phosphotyrosyl phosphatase activator (PTPA) NP_540037.1 1164924 R 224914 CDS NP_540038.1 17987404 1196832 complement(1165756..1166079) 1 NC_003317.1 hypothetical protein 1166079 1196832 BMEI1121 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540038.1 1165756 R 224914 CDS NP_540039.1 17987405 1196833 1166335..1167099 1 NC_003317.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazolesuccinocarboxamide synthase 1167099 1196833 BMEI1122 Brucella melitensis bv. 1 str. 16M phosphoribosylaminoimidazolesuccinocarboxamide synthase NP_540039.1 1166335 D 224914 CDS NP_540040.1 17987406 1196834 1167215..1167457 1 NC_003317.1 With PurL and PurQ catalyzes the conversion of formylglycinamide ribonucleotide, ATP, and glutamine to formylglycinamidine ribonucleotide, ADP, and glutamate in the fourth step of the purine biosynthetic pathway; phosphoribosylformylglycinamidine synthase subunit PurS 1167457 1196834 BMEI1123 Brucella melitensis bv. 1 str. 16M phosphoribosylformylglycinamidine synthase subunit PurS NP_540040.1 1167215 D 224914 CDS NP_540041.1 17987407 1196835 1167429..1168151 1 NC_003317.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase I 1168151 1196835 BMEI1124 Brucella melitensis bv. 1 str. 16M phosphoribosylformylglycinamidine synthase I NP_540041.1 1167429 D 224914 CDS NP_540042.1 17987408 1196836 1168403..1169050 1 NC_003317.1 maleylpyruvate isomerase 1169050 1196836 BMEI1125 Brucella melitensis bv. 1 str. 16M maleylpyruvate isomerase NP_540042.1 1168403 D 224914 CDS NP_540043.1 17987409 1196837 1169110..1169511 1 NC_003317.1 hypothetical protein 1169511 1196837 BMEI1126 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540043.1 1169110 D 224914 CDS NP_540044.1 17987410 1196838 1169665..1171920 1 NC_003317.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase II 1171920 1196838 BMEI1127 Brucella melitensis bv. 1 str. 16M phosphoribosylformylglycinamidine synthase II NP_540044.1 1169665 D 224914 CDS NP_540045.1 17987411 1196839 1172190..1172423 1 NC_003317.1 morphology/transcription regulator BolA family protein 1172423 1196839 BMEI1128 Brucella melitensis bv. 1 str. 16M morphology/transcription regulator BolA family protein NP_540045.1 1172190 D 224914 CDS NP_540046.1 17987412 1196840 1172548..1172940 1 NC_003317.1 glutaredoxin 1172940 1196840 BMEI1129 Brucella melitensis bv. 1 str. 16M glutaredoxin NP_540046.1 1172548 D 224914 CDS NP_540047.1 17987413 1196841 1173211..1174476 1 NC_003317.1 bicyclomycin resistance protein 1174476 1196841 BMEI1130 Brucella melitensis bv. 1 str. 16M bicyclomycin resistance protein NP_540047.1 1173211 D 224914 CDS NP_540048.1 17987414 1196842 complement(1174691..1175518) 1 NC_003317.1 inositol monophosphatase 1175518 1196842 BMEI1131 Brucella melitensis bv. 1 str. 16M inositol monophosphatase NP_540048.1 1174691 R 224914 CDS NP_540049.1 17987415 1196843 complement(1175505..1176386) 1 NC_003317.1 TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs; C32 tRNA thiolase 1176386 1196843 BMEI1132 Brucella melitensis bv. 1 str. 16M C32 tRNA thiolase NP_540049.1 1175505 R 224914 CDS NP_540050.1 17987416 1196844 complement(1176916..1177533) 1 NC_003317.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 1177533 rpsD 1196844 rpsD Brucella melitensis bv. 1 str. 16M 30S ribosomal protein S4 NP_540050.1 1176916 R 224914 CDS NP_540051.1 17987417 1196845 1178198..1178839 1 NC_003317.1 extensin 1178839 1196845 BMEI1134 Brucella melitensis bv. 1 str. 16M extensin NP_540051.1 1178198 D 224914 CDS NP_540052.1 17987418 1196846 1179111..1179524 1 NC_003317.1 hypothetical protein 1179524 1196846 BMEI1135 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540052.1 1179111 D 224914 CDS NP_540053.1 17987419 1196847 complement(1179569..1179766) 1 NC_003317.1 hypothetical protein 1179766 1196847 BMEI1136 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540053.1 1179569 R 224914 CDS NP_540054.1 17987420 1196848 complement(1179807..1183343) 1 NC_003317.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha 1183343 dnaE 1196848 dnaE Brucella melitensis bv. 1 str. 16M DNA polymerase III subunit alpha NP_540054.1 1179807 R 224914 CDS NP_540055.1 17987421 1196849 complement(1183957..1184826) 1 NC_003317.1 lipoprotein releasing system ATP-binding protein LOLD 1184826 1196849 BMEI1138 Brucella melitensis bv. 1 str. 16M lipoprotein releasing system ATP-binding protein LOLD NP_540055.1 1183957 R 224914 CDS NP_540056.1 17987422 1196850 complement(1184640..1185908) 1 NC_003317.1 lipoprotein releasing system transmembrane protein LOLE 1185908 1196850 BMEI1139 Brucella melitensis bv. 1 str. 16M lipoprotein releasing system transmembrane protein LOLE NP_540056.1 1184640 R 224914 CDS NP_540057.1 17987423 1196851 complement(1185950..1187287) 1 NC_003317.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 1187287 1196851 BMEI1140 Brucella melitensis bv. 1 str. 16M prolyl-tRNA synthetase NP_540057.1 1185950 R 224914 CDS NP_540058.1 17987424 1196852 complement(1188126..1188395) 1 NC_003317.1 hypothetical protein 1188395 1196852 BMEI1141 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540058.1 1188126 R 224914 CDS NP_540059.1 17987425 1196853 complement(1188398..1188808) 1 NC_003317.1 lactoylglutathione lyase 1188808 1196853 BMEI1142 Brucella melitensis bv. 1 str. 16M lactoylglutathione lyase NP_540059.1 1188398 R 224914 CDS NP_540060.1 17987426 1196854 complement(1188842..1190518) 1 NC_003317.1 metal dependent hydrolase 1190518 1196854 BMEI1143 Brucella melitensis bv. 1 str. 16M metal dependent hydrolase NP_540060.1 1188842 R 224914 CDS NP_540061.1 17987427 1196855 complement(1190712..1191575) 1 NC_003317.1 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 1191575 1196855 BMEI1144 Brucella melitensis bv. 1 str. 16M biotin--protein ligase NP_540061.1 1190712 R 224914 CDS NP_540062.1 17987428 1196856 complement(1191535..1192971) 1 NC_003317.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit N 1192971 1196856 BMEI1145 Brucella melitensis bv. 1 str. 16M NADH dehydrogenase subunit N NP_540062.1 1191535 R 224914 CDS NP_540063.1 17987429 1196857 complement(1192993..1194501) 1 NC_003317.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit M 1194501 1196857 BMEI1146 Brucella melitensis bv. 1 str. 16M NADH dehydrogenase subunit M NP_540063.1 1192993 R 224914 CDS NP_540064.1 17987430 1196858 complement(1194501..1196486) 1 NC_003317.1 Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit L 1196486 1196858 BMEI1147 Brucella melitensis bv. 1 str. 16M NADH dehydrogenase subunit L NP_540064.1 1194501 R 224914 CDS NP_540065.1 17987431 1196859 complement(1196494..1196802) 1 NC_003317.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit K 1196802 1196859 BMEI1148 Brucella melitensis bv. 1 str. 16M NADH dehydrogenase subunit K NP_540065.1 1196494 R 224914 CDS NP_540066.1 17987432 1196860 complement(1196813..1197382) 1 NC_003317.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit J 1197382 1196860 BMEI1149 Brucella melitensis bv. 1 str. 16M NADH dehydrogenase subunit J NP_540066.1 1196813 R 224914 CDS NP_540067.1 17987433 1196861 complement(1197604..1198095) 1 NC_003317.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I 1198095 1196861 BMEI1150 Brucella melitensis bv. 1 str. 16M NADH dehydrogenase subunit I NP_540067.1 1197604 R 224914 CDS NP_540068.2 161511137 1196862 complement(1198108..1199151) 1 NC_003317.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit H 1199151 1196862 BMEI1151 Brucella melitensis bv. 1 str. 16M NADH dehydrogenase subunit H NP_540068.2 1198108 R 224914 CDS NP_540069.1 17987435 1196863 complement(1199171..1201255) 1 NC_003317.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit G 1201255 1196863 BMEI1152 Brucella melitensis bv. 1 str. 16M NADH dehydrogenase subunit G NP_540069.1 1199171 R 224914 CDS NP_540070.1 17987436 1196864 complement(1201390..1202697) 1 NC_003317.1 part of NADH-ubiquinone oxidoreductase complex I; shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase; NADH dehydrogenase I subunit F 1202697 1196864 BMEI1153 Brucella melitensis bv. 1 str. 16M NADH dehydrogenase I subunit F NP_540070.1 1201390 R 224914 CDS NP_540071.1 17987437 1196865 complement(1202701..1203414) 1 NC_003317.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit E 1203414 1196865 BMEI1154 Brucella melitensis bv. 1 str. 16M NADH dehydrogenase subunit E NP_540071.1 1202701 R 224914 CDS NP_540072.1 17987438 1196866 complement(1203414..1204604) 1 NC_003317.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit D 1204604 1196866 BMEI1155 Brucella melitensis bv. 1 str. 16M NADH dehydrogenase subunit D NP_540072.1 1203414 R 224914 CDS NP_540073.1 17987439 1196867 complement(1204622..1205230) 1 NC_003317.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit C 1205230 1196867 BMEI1156 Brucella melitensis bv. 1 str. 16M NADH dehydrogenase subunit C NP_540073.1 1204622 R 224914 CDS NP_540074.1 17987440 1196868 complement(1205343..1205945) 1 NC_003317.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B 1205945 1196868 BMEI1157 Brucella melitensis bv. 1 str. 16M NADH dehydrogenase subunit B NP_540074.1 1205343 R 224914 CDS NP_540075.1 17987441 1196869 complement(1205915..1206280) 1 NC_003317.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit A 1206280 1196869 BMEI1158 Brucella melitensis bv. 1 str. 16M NADH dehydrogenase subunit A NP_540075.1 1205915 R 224914 CDS NP_540076.1 17987442 1196870 1206788..1206991 1 NC_003317.1 hypothetical protein 1206991 1196870 BMEI1159 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540076.1 1206788 D 224914 CDS NP_540077.1 17987443 1196871 1207855..1208256 1 NC_003317.1 hypothetical protein 1208256 1196871 BMEI1160 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540077.1 1207855 D 224914 CDS NP_540078.1 17987444 1196872 complement(1208702..1209076) 1 NC_003317.1 hypothetical protein 1209076 1196872 BMEI1161 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540078.1 1208702 R 224914 CDS NP_540079.1 17987445 1196873 complement(1209094..1209603) 1 NC_003317.1 hypothetical protein 1209603 1196873 BMEI1162 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540079.1 1209094 R 224914 CDS NP_540080.1 17987446 1196874 complement(1209738..1210016) 1 NC_003317.1 transposase 1210016 1196874 BMEI1163 Brucella melitensis bv. 1 str. 16M transposase NP_540080.1 1209738 R 224914 CDS NP_540081.1 17987447 1196875 complement(1210013..1210381) 1 NC_003317.1 transposase 1210381 1196875 BMEI1164 Brucella melitensis bv. 1 str. 16M transposase NP_540081.1 1210013 R 224914 CDS NP_540082.1 17987448 1196876 1211011..1211463 1 NC_003317.1 hypothetical protein 1211463 1196876 BMEI1165 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540082.1 1211011 D 224914 CDS NP_540083.1 17987449 1196877 complement(1211535..1212839) 1 NC_003317.1 catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol; O-acetylhomoserine aminocarboxypropyltransferase 1212839 1196877 BMEI1166 Brucella melitensis bv. 1 str. 16M O-acetylhomoserine aminocarboxypropyltransferase NP_540083.1 1211535 R 224914 CDS NP_540084.1 17987450 1196878 1213093..1213497 1 NC_003317.1 hypothetical protein 1213497 1196878 BMEI1167 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540084.1 1213093 D 224914 CDS NP_540085.1 17987451 1196879 1213733..1214197 1 NC_003317.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 1214197 rplM 1196879 rplM Brucella melitensis bv. 1 str. 16M 50S ribosomal protein L13 NP_540085.1 1213733 D 224914 CDS NP_540086.1 17987452 1196880 1214200..1214676 1 NC_003317.1 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 1214676 rpsI 1196880 rpsI Brucella melitensis bv. 1 str. 16M 30S ribosomal protein S9 NP_540086.1 1214200 D 224914 CDS NP_540087.1 17987453 1196881 1214767..1215717 1 NC_003317.1 catalyzes the formation of putrescine from agmatine; agmatinase 1215717 1196881 BMEI1170 Brucella melitensis bv. 1 str. 16M agmatinase NP_540087.1 1214767 D 224914 CDS NP_540088.1 17987454 1196882 1215807..1216739 1 NC_003317.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis; N-acetyl-gamma-glutamyl-phosphate reductase 1216739 argC 1196882 argC Brucella melitensis bv. 1 str. 16M N-acetyl-gamma-glutamyl-phosphate reductase NP_540088.1 1215807 D 224914 CDS NP_540089.1 17987455 1196883 complement(1216892..1217992) 1 NC_003317.1 cytochrome C oxidase assembly protein COX15 1217992 1196883 BMEI1172 Brucella melitensis bv. 1 str. 16M cytochrome C oxidase assembly protein COX15 NP_540089.1 1216892 R 224914 CDS NP_540090.1 17987456 1196884 1218368..1218538 1 NC_003317.1 hypothetical protein 1218538 1196884 BMEI1173 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540090.1 1218368 D 224914 CDS NP_540091.1 17987457 1196885 complement(1218606..1219151) 1 NC_003317.1 chromosome partitioning protein ParA 1219151 1196885 BMEI1174 Brucella melitensis bv. 1 str. 16M chromosome partitioning protein ParA NP_540091.1 1218606 R 224914 CDS NP_540092.1 17987458 1196886 1219392..1219979 1 NC_003317.1 capsule polysaccharide export protein precursor 1219979 1196886 BMEI1175 Brucella melitensis bv. 1 str. 16M capsule polysaccharide export protein precursor NP_540092.1 1219392 D 224914 CDS NP_540093.1 17987459 1196887 1219985..1220203 1 NC_003317.1 hypothetical protein 1220203 1196887 BMEI1176 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540093.1 1219985 D 224914 CDS NP_540094.1 17987460 1196888 1220333..1221871 1 NC_003317.1 colanic biosynthesis UDP-glucose lipid carrier transferase 1221871 1196888 BMEI1177 Brucella melitensis bv. 1 str. 16M colanic biosynthesis UDP-glucose lipid carrier transferase NP_540094.1 1220333 D 224914 CDS NP_540095.1 17987461 1196889 complement(1222584..1223165) 1 NC_003317.1 MerR family transcriptional regulator 1223165 1196889 BMEI1178 Brucella melitensis bv. 1 str. 16M MerR family transcriptional regulator NP_540095.1 1222584 R 224914 CDS NP_540096.1 17987462 1196890 complement(1223660..1224046) 1 NC_003317.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit alpha 1224046 ihfA 1196890 ihfA Brucella melitensis bv. 1 str. 16M integration host factor subunit alpha NP_540096.1 1223660 R 224914 CDS NP_540097.1 17987463 1196891 complement(1224102..1225073) 1 NC_003317.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase 1225073 1196891 BMEI1180 Brucella melitensis bv. 1 str. 16M 3-oxoacyl-ACP synthase NP_540097.1 1224102 R 224914 CDS NP_540098.1 17987464 1196892 complement(1225321..1226361) 1 NC_003317.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; glycerol-3-phosphate acyltransferase PlsX 1226361 1196892 BMEI1181 Brucella melitensis bv. 1 str. 16M glycerol-3-phosphate acyltransferase PlsX NP_540098.1 1225321 R 224914 CDS NP_540099.1 17987465 1196893 complement(1226479..1227036) 1 NC_003317.1 hypothetical protein 1227036 1196893 BMEI1182 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540099.1 1226479 R 224914 CDS NP_540100.1 17987466 1196894 complement(1227156..1227710) 1 NC_003317.1 hypothetical protein 1227710 1196894 BMEI1183 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540100.1 1227156 R 224914 CDS NP_540101.1 17987467 1196895 1227815..1228318 1 NC_003317.1 small protein A 1228318 1196895 BMEI1184 Brucella melitensis bv. 1 str. 16M small protein A NP_540101.1 1227815 D 224914 CDS NP_540102.2 161511136 1196896 complement(1228390..1230540) 1 NC_003317.1 pyrophosphate-energized proton pump; pyrophosphate-energized inorganic pyrophosphatase; H+-PPase; can cleave pyrophosphate to two phosphates; can generate a proton motive force and drive pyrophosphate synthesis when PMF is sufficient; membrane-bound proton-translocating pyrophosphatase 1230540 hppA 1196896 hppA Brucella melitensis bv. 1 str. 16M membrane-bound proton-translocating pyrophosphatase NP_540102.2 1228390 R 224914 CDS NP_540103.1 17987469 1196897 complement(1230997..1231512) 1 NC_003317.1 Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 1231512 nusB 1196897 nusB Brucella melitensis bv. 1 str. 16M transcription antitermination protein NusB NP_540103.1 1230997 R 224914 CDS NP_540104.1 17987470 1196898 complement(1231518..1231991) 1 NC_003317.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 1231991 ribH 1196898 ribH Brucella melitensis bv. 1 str. 16M 6,7-dimethyl-8-ribityllumazine synthase NP_540104.1 1231518 R 224914 CDS NP_540105.1 17987471 1196899 complement(1232074..1232685) 1 NC_003317.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 1232685 1196899 BMEI1188 Brucella melitensis bv. 1 str. 16M riboflavin synthase subunit alpha NP_540105.1 1232074 R 224914 CDS NP_540106.1 17987472 1196900 complement(1232682..1233803) 1 NC_003317.1 diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase 1233803 1196900 BMEI1189 Brucella melitensis bv. 1 str. 16M diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase NP_540106.1 1232682 R 224914 CDS NP_540107.1 17987473 1196901 complement(1233805..1234281) 1 NC_003317.1 transcriptional regulator NrdR 1234281 nrdR 1196901 nrdR Brucella melitensis bv. 1 str. 16M transcriptional regulator NrdR NP_540107.1 1233805 R 224914 CDS NP_540108.1 17987474 1196902 complement(1234538..1235404) 1 NC_003317.1 serine hydroxymethyltransferase 1235404 1196902 BMEI1191 Brucella melitensis bv. 1 str. 16M serine hydroxymethyltransferase NP_540108.1 1234538 R 224914 CDS NP_540109.1 17987475 1196903 complement(1235101..1235853) 1 NC_003317.1 serine hydroxymethyltransferase 1235853 1196903 BMEI1192 Brucella melitensis bv. 1 str. 16M serine hydroxymethyltransferase NP_540109.1 1235101 R 224914 CDS NP_540110.1 17987476 1196904 complement(1236084..1237286) 1 NC_003317.1 cell wall degradation protein 1237286 1196904 BMEI1193 Brucella melitensis bv. 1 str. 16M cell wall degradation protein NP_540110.1 1236084 R 224914 CDS NP_540111.1 17987477 1196905 complement(1237747..1238346) 1 NC_003317.1 exopolysaccharide synthesis regulatory protein MUCS 1238346 1196905 BMEI1194 Brucella melitensis bv. 1 str. 16M exopolysaccharide synthesis regulatory protein MUCS NP_540111.1 1237747 R 224914 CDS NP_540112.1 17987478 1196906 complement(1238577..1239005) 1 NC_003317.1 hypothetical protein 1239005 1196906 BMEI1195 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540112.1 1238577 R 224914 CDS NP_540113.1 17987479 1196907 complement(1239025..1240074) 1 NC_003317.1 catalyzes the formation of 3-hydroxy-2-methylpropanoate from 3-hydroxy-2-methylpropanoyl-CoA; 3-hydroxyisobutyryl-CoA hydrolase 1240074 1196907 BMEI1196 Brucella melitensis bv. 1 str. 16M 3-hydroxyisobutyryl-CoA hydrolase NP_540113.1 1239025 R 224914 CDS NP_540114.1 17987480 1196908 1240242..1241279 1 NC_003317.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase 1241279 1196908 BMEI1197 Brucella melitensis bv. 1 str. 16M delta-aminolevulinic acid dehydratase NP_540114.1 1240242 D 224914 CDS NP_540115.1 17987481 1196909 1241456..1241896 1 NC_003317.1 hypothetical protein 1241896 1196909 BMEI1198 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540115.1 1241456 D 224914 CDS NP_540116.1 17987482 1196910 1242017..1242766 1 NC_003317.1 Conjugates Arg from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate; arginyl-tRNA-protein transferase 1242766 1196910 BMEI1199 Brucella melitensis bv. 1 str. 16M arginyl-tRNA-protein transferase NP_540116.1 1242017 D 224914 CDS NP_540117.1 17987483 1196911 complement(1242945..1245272) 1 NC_003317.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 1245272 1196911 BMEI1200 Brucella melitensis bv. 1 str. 16M DNA topoisomerase IV subunit A NP_540117.1 1242945 R 224914 CDS NP_540118.1 17987484 1196912 1245741..1246853 1 NC_003317.1 hypothetical protein 1246853 1196912 BMEI1201 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540118.1 1245741 D 224914 CDS NP_540119.1 17987485 1196913 complement(1246894..1248681) 1 NC_003317.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 1248681 aspS 1196913 aspS Brucella melitensis bv. 1 str. 16M aspartyl-tRNA synthetase NP_540119.1 1246894 R 224914 CDS NP_540120.1 17987486 1196914 1248908..1250065 1 NC_003317.1 ribonuclease D 1250065 1196914 BMEI1203 Brucella melitensis bv. 1 str. 16M ribonuclease D NP_540120.1 1248908 D 224914 CDS NP_540121.1 17987487 1196915 complement(1250187..1251725) 1 NC_003317.1 exopolyphosphatase 1251725 1196915 BMEI1204 Brucella melitensis bv. 1 str. 16M exopolyphosphatase NP_540121.1 1250187 R 224914 CDS NP_540122.1 17987488 1196916 complement(1251722..1254073) 1 NC_003317.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate; polyphosphate kinase 1254073 1196916 BMEI1205 Brucella melitensis bv. 1 str. 16M polyphosphate kinase NP_540122.1 1251722 R 224914 CDS NP_540123.1 17987489 1196917 1254248..1254502 1 NC_003317.1 hypothetical protein 1254502 1196917 BMEI1206 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540123.1 1254248 D 224914 CDS NP_540124.1 17987490 1196918 1254550..1255737 1 NC_003317.1 catalyzes the formation of catechol from salicylate; salicylate hydroxylase 1255737 1196918 BMEI1207 Brucella melitensis bv. 1 str. 16M salicylate hydroxylase NP_540124.1 1254550 D 224914 CDS NP_540125.1 17987491 1196919 complement(1255785..1256594) 1 NC_003317.1 general L-amino acid transport ATP-binding protein AAPP 1256594 1196919 BMEI1208 Brucella melitensis bv. 1 str. 16M general L-amino acid transport ATP-binding protein AAPP NP_540125.1 1255785 R 224914 CDS NP_540126.1 17987492 1196920 complement(1256615..1257646) 1 NC_003317.1 general L-amino acid transport system permease protein AAPM 1257646 1196920 BMEI1209 Brucella melitensis bv. 1 str. 16M general L-amino acid transport system permease protein AAPM NP_540126.1 1256615 R 224914 CDS NP_540127.1 17987493 1196921 complement(1257774..1258967) 1 NC_003317.1 general L-amino acid transport system permease aapQ 1258967 1196921 BMEI1210 Brucella melitensis bv. 1 str. 16M general L-amino acid transport system permease aapQ NP_540127.1 1257774 R 224914 CDS NP_540128.1 17987494 1196922 complement(1259264..1260295) 1 NC_003317.1 general L-amino acid-binding periplasmic protein AAPJ precursor 1260295 1196922 BMEI1211 Brucella melitensis bv. 1 str. 16M general L-amino acid-binding periplasmic protein AAPJ precursor NP_540128.1 1259264 R 224914 CDS NP_540129.1 17987495 1196923 complement(1260750..1261457) 1 NC_003317.1 phosphatidylglycerophosphatase B 1261457 1196923 BMEI1212 Brucella melitensis bv. 1 str. 16M phosphatidylglycerophosphatase B NP_540129.1 1260750 R 224914 CDS NP_540130.1 17987496 1196924 1261569..1262897 1 NC_003317.1 catalyzes the formation of L-homocysteine from cystathionine; cystathionine beta-lyase 1262897 1196924 BMEI1213 Brucella melitensis bv. 1 str. 16M cystathionine beta-lyase NP_540130.1 1261569 D 224914 CDS NP_540131.1 17987497 1196925 1263121..1263390 1 NC_003317.1 hypothetical protein 1263390 1196925 BMEI1214 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540131.1 1263121 D 224914 CDS NP_540132.1 17987498 1196926 1263562..1264062 1 NC_003317.1 hypothetical protein 1264062 1196926 BMEI1215 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540132.1 1263562 D 224914 CDS NP_540133.1 17987499 1196927 complement(1264446..1264982) 1 NC_003317.1 hypothetical protein 1264982 1196927 BMEI1216 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540133.1 1264446 R 224914 CDS NP_540134.1 17987500 1196928 complement(1265413..1266816) 1 NC_003317.1 ApeA 1266816 1196928 BMEI1217 Brucella melitensis bv. 1 str. 16M ApeA NP_540134.1 1265413 R 224914 CDS NP_540135.1 17987501 1196929 complement(1267240..1268547) 1 NC_003317.1 phage protein 1268547 1196929 BMEI1218 Brucella melitensis bv. 1 str. 16M phage protein NP_540135.1 1267240 R 224914 CDS NP_540136.1 17987502 1196930 1268794..1268985 1 NC_003317.1 hypothetical protein 1268985 1196930 BMEI1219 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540136.1 1268794 D 224914 CDS NP_540137.1 17987503 1196931 complement(1269023..1270039) 1 NC_003317.1 hypothetical protein 1270039 1196931 BMEI1220 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540137.1 1269023 R 224914 CDS NP_540138.1 17987504 1196932 complement(1270857..1271243) 1 NC_003317.1 hypothetical protein 1271243 1196932 BMEI1221 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540138.1 1270857 R 224914 CDS NP_540139.1 17987505 1196933 complement(1271273..1271833) 1 NC_003317.1 hypothetical protein 1271833 1196933 BMEI1222 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540139.1 1271273 R 224914 CDS NP_540140.1 17987506 1196934 complement(1271799..1273760) 1 NC_003317.1 transposase 1273760 1196934 BMEI1223 Brucella melitensis bv. 1 str. 16M transposase NP_540140.1 1271799 R 224914 CDS NP_540141.1 17987507 1196935 complement(1273913..1274464) 1 NC_003317.1 hypothetical protein 1274464 1196935 BMEI1224 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540141.1 1273913 R 224914 CDS NP_540142.1 17987508 1196936 1275189..1275608 1 NC_003317.1 hypothetical protein 1275608 1196936 BMEI1225 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540142.1 1275189 D 224914 CDS NP_540143.1 17987509 1196937 1275696..1276427 1 NC_003317.1 transcriptional regulator 1276427 1196937 BMEI1226 Brucella melitensis bv. 1 str. 16M transcriptional regulator NP_540143.1 1275696 D 224914 CDS NP_540144.1 17987510 1196938 1276402..1277937 1 NC_003317.1 hypothetical protein 1277937 1196938 BMEI1227 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540144.1 1276402 D 224914 CDS NP_540145.1 17987511 1196939 1277934..1278479 1 NC_003317.1 adenylate kinase 1278479 1196939 BMEI1228 Brucella melitensis bv. 1 str. 16M adenylate kinase NP_540145.1 1277934 D 224914 CDS NP_540146.1 17987512 1196940 1278804..1279415 1 NC_003317.1 exonuclease 1279415 1196940 BMEI1229 Brucella melitensis bv. 1 str. 16M exonuclease NP_540146.1 1278804 D 224914 CDS NP_540147.1 17987513 1196941 complement(1279636..1280220) 1 NC_003317.1 hypothetical protein 1280220 1196941 BMEI1230 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540147.1 1279636 R 224914 CDS NP_540148.1 17987514 1196942 complement(1280792..1281097) 1 NC_003317.1 NADH-ubiquinone oxidoreductase 18 KD subunit 1281097 1196942 BMEI1231 Brucella melitensis bv. 1 str. 16M NADH-ubiquinone oxidoreductase 18 KD subunit NP_540148.1 1280792 R 224914 CDS NP_540149.1 17987515 1196943 1281631..1282257 1 NC_003317.1 L-lactate permease 1282257 1196943 BMEI1232 Brucella melitensis bv. 1 str. 16M L-lactate permease NP_540149.1 1281631 D 224914 CDS NP_540150.1 17987516 1196944 1282306..1283325 1 NC_003317.1 L-lactate permease 1283325 1196944 BMEI1233 Brucella melitensis bv. 1 str. 16M L-lactate permease NP_540150.1 1282306 D 224914 CDS NP_540151.1 17987517 1196945 complement(1283734..1283952) 1 NC_003317.1 hypothetical protein 1283952 1196945 BMEI1234 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540151.1 1283734 R 224914 CDS NP_540152.1 17987518 1196946 1284003..1284728 1 NC_003317.1 short-chain dehydrogenase 1284728 1196946 BMEI1235 Brucella melitensis bv. 1 str. 16M short-chain dehydrogenase NP_540152.1 1284003 D 224914 CDS NP_540153.1 17987519 1196947 1284888..1285586 1 NC_003317.1 exported proline-rich protein 1285586 1196947 BMEI1236 Brucella melitensis bv. 1 str. 16M exported proline-rich protein NP_540153.1 1284888 D 224914 CDS NP_540154.1 17987520 1196948 complement(1285583..1286452) 1 NC_003317.1 UDP-glucose 4-epimerase 1286452 1196948 BMEI1237 Brucella melitensis bv. 1 str. 16M UDP-glucose 4-epimerase NP_540154.1 1285583 R 224914 CDS NP_540155.1 17987521 1196949 complement(1286449..1287144) 1 NC_003317.1 hypothetical protein 1287144 1196949 BMEI1238 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540155.1 1286449 R 224914 CDS NP_540156.1 17987522 1196950 complement(1287184..1288332) 1 NC_003317.1 permease 1288332 1196950 BMEI1239 Brucella melitensis bv. 1 str. 16M permease NP_540156.1 1287184 R 224914 CDS NP_540157.1 17987523 1196951 1288822..1289901 1 NC_003317.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 1289901 1196951 BMEI1240 Brucella melitensis bv. 1 str. 16M phosphoribosylaminoimidazole synthetase NP_540157.1 1288822 D 224914 CDS NP_540158.1 17987524 1196952 1289898..1290515 1 NC_003317.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 1290515 purN 1196952 purN Brucella melitensis bv. 1 str. 16M phosphoribosylglycinamide formyltransferase NP_540158.1 1289898 D 224914 CDS NP_540159.1 17987525 1196953 1290727..1291215 1 NC_003317.1 hypothetical protein 1291215 1196953 BMEI1242 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540159.1 1290727 D 224914 CDS NP_540160.1 17987526 1196954 complement(1291442..1293568) 1 NC_003317.1 formate dehydrogenase subunit alpha 1293568 1196954 BMEI1243 Brucella melitensis bv. 1 str. 16M formate dehydrogenase subunit alpha NP_540160.1 1291442 R 224914 CDS NP_540161.1 17987527 1196955 complement(1293646..1294491) 1 NC_003317.1 transporter, DME family 1294491 1196955 BMEI1244 Brucella melitensis bv. 1 str. 16M transporter, DME family NP_540161.1 1293646 R 224914 CDS NP_540162.1 17987528 1196956 1294611..1295519 1 NC_003317.1 florfenicol resistance protein 1295519 1196956 BMEI1245 Brucella melitensis bv. 1 str. 16M florfenicol resistance protein NP_540162.1 1294611 D 224914 CDS NP_540163.1 17987529 1196957 1295455..1296072 1 NC_003317.1 hypothetical protein 1296072 1196957 BMEI1246 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540163.1 1295455 D 224914 CDS NP_540164.1 17987530 1196958 1296097..1296774 1 NC_003317.1 ribonuclease 1296774 1196958 BMEI1247 Brucella melitensis bv. 1 str. 16M ribonuclease NP_540164.1 1296097 D 224914 CDS NP_540165.1 17987531 1196959 1296829..1297428 1 NC_003317.1 glutathione S-transferase 1297428 1196959 BMEI1248 Brucella melitensis bv. 1 str. 16M glutathione S-transferase NP_540165.1 1296829 D 224914 CDS NP_540166.1 17987532 1196960 complement(1297525..1298166) 1 NC_003317.1 hypothetical protein 1298166 1196960 BMEI1249 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540166.1 1297525 R 224914 CDS NP_540167.1 17987533 1196961 1298478..1299323 1 NC_003317.1 short chain dehydrogenase 1299323 1196961 BMEI1250 Brucella melitensis bv. 1 str. 16M short chain dehydrogenase NP_540167.1 1298478 D 224914 CDS NP_540168.1 17987534 1196962 1299323..1301380 1 NC_003317.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 1301380 uvrC 1196962 uvrC Brucella melitensis bv. 1 str. 16M excinuclease ABC subunit C NP_540168.1 1299323 D 224914 CDS NP_540169.1 17987535 1196963 1301499..1302083 1 NC_003317.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 1302083 1196963 BMEI1252 Brucella melitensis bv. 1 str. 16M CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase NP_540169.1 1301499 D 224914 CDS NP_540170.1 17987536 1196964 1302088..1302345 1 NC_003317.1 molybdopterin (MPT) converting factor subunit 1 1302345 1196964 BMEI1253 Brucella melitensis bv. 1 str. 16M molybdopterin (MPT) converting factor subunit 1 NP_540170.1 1302088 D 224914 CDS NP_540171.1 17987537 1196965 1302347..1302838 1 NC_003317.1 molybdopterin (MPT) converting factor, subunit 2 1302838 1196965 BMEI1254 Brucella melitensis bv. 1 str. 16M molybdopterin (MPT) converting factor, subunit 2 NP_540171.1 1302347 D 224914 CDS NP_540172.1 17987538 1196966 1303119..1303877 1 NC_003317.1 glycoprotein/polysaccharide metabolism 1303877 1196966 BMEI1255 Brucella melitensis bv. 1 str. 16M glycoprotein/polysaccharide metabolism NP_540172.1 1303119 D 224914 CDS NP_540173.1 17987539 1196967 complement(1303986..1304408) 1 NC_003317.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase 1304408 ndk 1196967 ndk Brucella melitensis bv. 1 str. 16M nucleoside diphosphate kinase NP_540173.1 1303986 R 224914 CDS NP_540174.1 17987540 1196968 1304637..1305149 1 NC_003317.1 DinB family DNA polymerase 1305149 1196968 BMEI1257 Brucella melitensis bv. 1 str. 16M DinB family DNA polymerase NP_540174.1 1304637 D 224914 CDS NP_540175.1 17987541 1196969 1305153..1307093 1 NC_003317.1 ABC transporter ATP-binding protein 1307093 1196969 BMEI1258 Brucella melitensis bv. 1 str. 16M ABC transporter ATP-binding protein NP_540175.1 1305153 D 224914 CDS NP_540176.1 17987542 1196970 complement(1307153..1307716) 1 NC_003317.1 hypothetical protein 1307716 1196970 BMEI1259 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540176.1 1307153 R 224914 CDS NP_540177.1 17987543 1196971 complement(1307716..1308213) 1 NC_003317.1 binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit chi 1308213 1196971 BMEI1260 Brucella melitensis bv. 1 str. 16M DNA polymerase III subunit chi NP_540177.1 1307716 R 224914 CDS NP_540178.1 17987544 1196972 complement(1308237..1309694) 1 NC_003317.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase 1309694 1196972 BMEI1261 Brucella melitensis bv. 1 str. 16M leucyl aminopeptidase NP_540178.1 1308237 R 224914 CDS NP_540179.1 17987545 1196973 1310138..1311346 1 NC_003317.1 hypothetical protein 1311346 1196973 BMEI1262 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540179.1 1310138 D 224914 CDS NP_540180.1 17987546 1196974 1311343..1312431 1 NC_003317.1 permeases 1312431 1196974 BMEI1263 Brucella melitensis bv. 1 str. 16M permeases NP_540180.1 1311343 D 224914 CDS NP_540181.1 17987547 1196975 1312437..1314830 1 NC_003317.1 organic solvent tolerance protein 1314830 1196975 BMEI1264 Brucella melitensis bv. 1 str. 16M organic solvent tolerance protein NP_540181.1 1312437 D 224914 CDS NP_540182.1 17987548 1196976 1315161..1316114 1 NC_003317.1 survival protein surA precursor (peptidyl-prolyl cis-trans isomerase surA) 1316114 1196976 BMEI1265 Brucella melitensis bv. 1 str. 16M survival protein surA precursor (peptidyl-prolyl cis-trans isomerase surA) NP_540182.1 1315161 D 224914 CDS NP_540183.1 17987549 1196977 1315999..1317210 1 NC_003317.1 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate); 4-hydroxythreonine-4-phosphate dehydrogenase 1317210 pdxA 1196977 pdxA Brucella melitensis bv. 1 str. 16M 4-hydroxythreonine-4-phosphate dehydrogenase NP_540183.1 1315999 D 224914 CDS NP_540184.1 17987550 1196978 1317207..1318037 1 NC_003317.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 1318037 ksgA 1196978 ksgA Brucella melitensis bv. 1 str. 16M dimethyladenosine transferase NP_540184.1 1317207 D 224914 CDS NP_540185.1 17987551 1196979 complement(1318105..1319523) 1 NC_003317.1 lysostaphin 1319523 1196979 BMEI1268 Brucella melitensis bv. 1 str. 16M lysostaphin NP_540185.1 1318105 R 224914 CDS NP_540186.1 17987552 1196980 complement(1319971..1320915) 1 NC_003317.1 chloramphenicol-sensitive protein RARD 1320915 1196980 BMEI1269 Brucella melitensis bv. 1 str. 16M chloramphenicol-sensitive protein RARD NP_540186.1 1319971 R 224914 CDS NP_540187.1 17987553 1196981 complement(1321139..1322770) 1 NC_003317.1 catalyzes the formation of 2-isopropylmalate from 1-methyl-2-oxobutanoate and acetyl-CoA; alpha-isopropylmalate/homocitrate synthase family transferase 1322770 1196981 BMEI1270 Brucella melitensis bv. 1 str. 16M alpha-isopropylmalate/homocitrate synthase family transferase NP_540187.1 1321139 R 224914 CDS NP_540188.1 17987554 1196982 complement(1322752..1323057) 1 NC_003317.1 2-isopropylmalate synthase 1323057 1196982 BMEI1271 Brucella melitensis bv. 1 str. 16M 2-isopropylmalate synthase NP_540188.1 1322752 R 224914 CDS NP_540189.1 17987555 1196983 complement(1323039..1324559) 1 NC_003317.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 1324559 cysS 1196983 cysS Brucella melitensis bv. 1 str. 16M cysteinyl-tRNA synthetase NP_540189.1 1323039 R 224914 CDS NP_540190.1 17987556 1196984 1324706..1324921 1 NC_003317.1 hypothetical protein 1324921 1196984 BMEI1273 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540190.1 1324706 D 224914 CDS NP_540191.1 17987557 1196985 complement(1325070..1325684) 1 NC_003317.1 amino acid transporter LysE 1325684 1196985 BMEI1274 Brucella melitensis bv. 1 str. 16M amino acid transporter LysE NP_540191.1 1325070 R 224914 CDS NP_540192.1 17987558 1196986 complement(1325739..1326518) 1 NC_003317.1 hypothetical protein 1326518 1196986 BMEI1275 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540192.1 1325739 R 224914 CDS NP_540193.1 17987559 1196987 1326688..1327047 1 NC_003317.1 phosphohydrolase 1327047 1196987 BMEI1276 Brucella melitensis bv. 1 str. 16M phosphohydrolase NP_540193.1 1326688 D 224914 CDS NP_540194.1 17987560 1196988 1327175..1327510 1 NC_003317.1 hypothetical protein 1327510 1196988 BMEI1277 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540194.1 1327175 D 224914 CDS NP_540195.1 17987561 1196989 complement(1327583..1328266) 1 NC_003317.1 hypothetical protein 1328266 1196989 BMEI1278 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540195.1 1327583 R 224914 CDS NP_540196.1 17987562 1196990 1327676..1327933 1 NC_003317.1 hypothetical protein 1327933 1196990 BMEI1279 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540196.1 1327676 D 224914 CDS NP_540197.1 17987563 1196991 1327982..1328746 1 NC_003317.1 hypothetical protein 1328746 1196991 BMEI1280 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540197.1 1327982 D 224914 CDS NP_540198.1 17987564 1196992 complement(1328795..1330231) 1 NC_003317.1 Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides; dihydroorotase 1330231 1196992 BMEI1281 Brucella melitensis bv. 1 str. 16M dihydroorotase NP_540198.1 1328795 R 224914 CDS NP_540199.1 17987565 1196993 1330215..1331078 1 NC_003317.1 glycine cleavage system protein T 1331078 1196993 BMEI1282 Brucella melitensis bv. 1 str. 16M glycine cleavage system protein T NP_540199.1 1330215 D 224914 CDS NP_540200.1 17987566 1196994 1331078..1331698 1 NC_003317.1 hypothetical protein 1331698 1196994 BMEI1283 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540200.1 1331078 D 224914 CDS NP_540201.1 17987567 1196995 1331695..1332204 1 NC_003317.1 tyrosine phosphatase 1332204 1196995 BMEI1284 Brucella melitensis bv. 1 str. 16M tyrosine phosphatase NP_540201.1 1331695 D 224914 CDS NP_540202.1 17987568 1196996 complement(1332182..1332925) 1 NC_003317.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 1332925 recO 1196996 recO Brucella melitensis bv. 1 str. 16M DNA repair protein RecO NP_540202.1 1332182 R 224914 CDS NP_540203.1 17987569 1196997 complement(1332952..1333887) 1 NC_003317.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 1333887 era 1196997 era Brucella melitensis bv. 1 str. 16M GTP-binding protein Era NP_540203.1 1332952 R 224914 CDS NP_540204.1 17987570 1196998 complement(1334032..1334769) 1 NC_003317.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 1334769 rncS 1196998 rncS Brucella melitensis bv. 1 str. 16M ribonuclease III NP_540204.1 1334032 R 224914 CDS NP_540205.1 17987571 1196999 complement(1334738..1335574) 1 NC_003317.1 signal peptidase I 1335574 1196999 BMEI1288 Brucella melitensis bv. 1 str. 16M signal peptidase I NP_540205.1 1334738 R 224914 CDS NP_540206.2 161511135 1197000 complement(1335631..1336035) 1 NC_003317.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase 1336035 acpS 1197000 acpS Brucella melitensis bv. 1 str. 16M 4'-phosphopantetheinyl transferase NP_540206.2 1335631 R 224914 CDS NP_540207.1 17987573 1197001 complement(1336032..1336604) 1 NC_003317.1 hypothetical protein 1336604 1197001 BMEI1290 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540207.1 1336032 R 224914 CDS NP_540208.1 17987574 1197002 complement(1336657..1337559) 1 NC_003317.1 AraC family transcriptional regulator 1337559 1197002 BMEI1291 Brucella melitensis bv. 1 str. 16M AraC family transcriptional regulator NP_540208.1 1336657 R 224914 CDS NP_540209.1 17987575 1197003 1337748..1338959 1 NC_003317.1 fosmidomycin resistance protein 1338959 1197003 BMEI1292 Brucella melitensis bv. 1 str. 16M fosmidomycin resistance protein NP_540209.1 1337748 D 224914 CDS NP_540210.1 17987576 1197004 complement(1339143..1340477) 1 NC_003317.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 1340477 1197004 BMEI1293 Brucella melitensis bv. 1 str. 16M coproporphyrinogen III oxidase NP_540210.1 1339143 R 224914 CDS NP_540211.1 17987577 1197005 complement(1340858..1341613) 1 NC_003317.1 nitrogen fixation regulation protein fixk 1341613 1197005 BMEI1294 Brucella melitensis bv. 1 str. 16M nitrogen fixation regulation protein fixk NP_540211.1 1340858 R 224914 CDS NP_540212.1 17987578 1197006 complement(1341773..1342351) 1 NC_003317.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 1342351 pyrE 1197006 pyrE Brucella melitensis bv. 1 str. 16M orotate phosphoribosyltransferase NP_540212.1 1341773 R 224914 CDS NP_540213.1 17987579 1197007 complement(1342359..1344641) 1 NC_003317.1 guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 1344641 1197007 BMEI1296 Brucella melitensis bv. 1 str. 16M guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase NP_540213.1 1342359 R 224914 CDS NP_540214.1 17987580 1197008 complement(1344852..1345253) 1 NC_003317.1 Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 1345253 1197008 BMEI1297 Brucella melitensis bv. 1 str. 16M DNA-directed RNA polymerase subunit omega NP_540214.1 1344852 R 224914 CDS NP_540215.1 17987581 1197009 1345650..1346225 1 NC_003317.1 hypothetical protein 1346225 1197009 BMEI1298 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540215.1 1345650 D 224914 CDS NP_540216.1 17987582 1197010 1346256..1346927 1 NC_003317.1 hypothetical protein 1346927 1197010 BMEI1299 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540216.1 1346256 D 224914 CDS NP_540217.1 17987583 1197011 complement(1347064..1347540) 1 NC_003317.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 1347540 smpB 1197011 smpB Brucella melitensis bv. 1 str. 16M SsrA-binding protein NP_540217.1 1347064 R 224914 CDS NP_540218.1 17987584 1197012 complement(1347631..1348554) 1 NC_003317.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 1348554 dapA 1197012 dapA Brucella melitensis bv. 1 str. 16M dihydrodipicolinate synthase NP_540218.1 1347631 R 224914 CDS NP_540219.1 17987585 1197013 1348988..1351045 1 NC_003317.1 soluble lytic murein transglycosylase 1351045 1197013 BMEI1302 Brucella melitensis bv. 1 str. 16M soluble lytic murein transglycosylase NP_540219.1 1348988 D 224914 CDS NP_540220.1 17987586 1197014 complement(1351108..1351473) 1 NC_003317.1 hypothetical protein 1351473 1197014 BMEI1303 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540220.1 1351108 R 224914 CDS NP_540221.1 17987587 1197015 complement(1352081..1352722) 1 NC_003317.1 porin 1352722 1197015 BMEI1304 Brucella melitensis bv. 1 str. 16M porin NP_540221.1 1352081 R 224914 CDS NP_540222.1 17987588 1197016 complement(1352866..1353993) 1 NC_003317.1 porin 1353993 1197016 BMEI1305 Brucella melitensis bv. 1 str. 16M porin NP_540222.1 1352866 R 224914 CDS NP_540223.1 17987589 1197017 1354796..1355899 1 NC_003317.1 porin 1355899 1197017 BMEI1306 Brucella melitensis bv. 1 str. 16M porin NP_540223.1 1354796 D 224914 CDS NP_540224.1 17987590 1197018 1356177..1357103 1 NC_003317.1 integrase 1357103 1197018 BMEI1307 Brucella melitensis bv. 1 str. 16M integrase NP_540224.1 1356177 D 224914 CDS NP_540225.1 17987591 1197019 1357385..1358035 1 NC_003317.1 histidinol-phosphate aminotransferase 1358035 1197019 BMEI1308 Brucella melitensis bv. 1 str. 16M histidinol-phosphate aminotransferase NP_540225.1 1357385 D 224914 CDS NP_540226.1 17987592 1197020 1357975..1358598 1 NC_003317.1 histidinol-phosphate aminotransferase 1358598 1197020 BMEI1309 Brucella melitensis bv. 1 str. 16M histidinol-phosphate aminotransferase NP_540226.1 1357975 D 224914 CDS NP_540227.1 17987593 1197021 1358571..1358990 1 NC_003317.1 hypothetical protein 1358990 1197021 BMEI1310 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540227.1 1358571 D 224914 CDS NP_540228.1 17987594 1197022 complement(1359035..1359535) 1 NC_003317.1 hypothetical protein 1359535 1197022 BMEI1311 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540228.1 1359035 R 224914 CDS NP_540229.1 17987595 1197023 1360460..1361113 1 NC_003317.1 hypothetical protein 1361113 1197023 BMEI1312 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540229.1 1360460 D 224914 CDS NP_540230.1 17987596 1197024 complement(1361173..1361430) 1 NC_003317.1 hypothetical protein 1361430 1197024 BMEI1313 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540230.1 1361173 R 224914 CDS NP_540231.1 17987597 1197025 1361700..1361939 1 NC_003317.1 hypothetical protein 1361939 1197025 BMEI1314 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540231.1 1361700 D 224914 CDS NP_540232.1 17987598 1197026 1361960..1362283 1 NC_003317.1 SN-glycerol-3-phosphate transport ATP-binding protein ugpC 1362283 1197026 BMEI1315 Brucella melitensis bv. 1 str. 16M SN-glycerol-3-phosphate transport ATP-binding protein ugpC NP_540232.1 1361960 D 224914 CDS NP_540233.1 17987599 1197027 complement(1362342..1363052) 1 NC_003317.1 glutathione S-transferase 1363052 1197027 BMEI1316 Brucella melitensis bv. 1 str. 16M glutathione S-transferase NP_540233.1 1362342 R 224914 CDS NP_540234.1 17987600 1197028 complement(1363130..1363426) 1 NC_003317.1 hypothetical protein 1363426 1197028 BMEI1317 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540234.1 1363130 R 224914 CDS NP_540235.2 161511134 1197029 1363619..1365121 1 NC_003317.1 Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile; AMP nucleosidase 1365121 1197029 BMEI1318 Brucella melitensis bv. 1 str. 16M AMP nucleosidase NP_540235.2 1363619 D 224914 CDS NP_540236.1 17987602 1197030 1365472..1366242 1 NC_003317.1 hypothetical protein 1366242 1197030 BMEI1319 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540236.1 1365472 D 224914 CDS NP_540237.1 17987603 1197031 complement(1366357..1368048) 1 NC_003317.1 electron transfer flavoprotein-ubiquinone oxidoreductase 1368048 1197031 BMEI1320 Brucella melitensis bv. 1 str. 16M electron transfer flavoprotein-ubiquinone oxidoreductase NP_540237.1 1366357 R 224914 CDS NP_540238.1 17987604 1197032 1368437..1369309 1 NC_003317.1 DNA polymerase 1369309 1197032 BMEI1321 Brucella melitensis bv. 1 str. 16M DNA polymerase NP_540238.1 1368437 D 224914 CDS NP_540239.1 17987605 1197033 1369471..1370727 1 NC_003317.1 major facilitator superfamily transporter 1370727 1197033 BMEI1322 Brucella melitensis bv. 1 str. 16M major facilitator superfamily transporter NP_540239.1 1369471 D 224914 CDS NP_540240.1 17987606 1197034 complement(1370732..1371691) 1 NC_003317.1 transporter, DME family 1371691 1197034 BMEI1323 Brucella melitensis bv. 1 str. 16M transporter, DME family NP_540240.1 1370732 R 224914 CDS NP_540241.1 17987607 1197035 1371917..1374568 1 NC_003317.1 aminopeptidase 1374568 pepN 1197035 pepN Brucella melitensis bv. 1 str. 16M aminopeptidase NP_540241.1 1371917 D 224914 CDS NP_540242.1 17987608 1197036 1374959..1377310 1 NC_003317.1 sensory transduction protein kinase 1377310 1197036 BMEI1325 Brucella melitensis bv. 1 str. 16M sensory transduction protein kinase NP_540242.1 1374959 D 224914 CDS NP_540243.1 17987609 1197037 1377527..1379692 1 NC_003317.1 hypothetical protein 1379692 1197037 BMEI1326 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540243.1 1377527 D 224914 CDS NP_540244.1 17987610 1197038 complement(1379737..1382553) 1 NC_003317.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase 1382553 1197038 BMEI1327 Brucella melitensis bv. 1 str. 16M bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase NP_540244.1 1379737 R 224914 CDS NP_540245.1 17987611 1197039 complement(1382811..1384214) 1 NC_003317.1 sensory transduction histidine kinase 1384214 1197039 BMEI1328 Brucella melitensis bv. 1 str. 16M sensory transduction histidine kinase NP_540245.1 1382811 R 224914 CDS NP_540246.1 17987612 1197040 complement(1384214..1384921) 1 NC_003317.1 two component response regulator 1384921 1197040 BMEI1329 Brucella melitensis bv. 1 str. 16M two component response regulator NP_540246.1 1384214 R 224914 CDS NP_540247.1 17987613 1197041 complement(1385015..1386556) 1 NC_003317.1 protease Do 1386556 1197041 BMEI1330 Brucella melitensis bv. 1 str. 16M protease Do NP_540247.1 1385015 R 224914 CDS NP_540248.1 17987614 1197042 complement(1386698..1387174) 1 NC_003317.1 cytochrome C-type biogenesis protein CYCL precursor 1387174 1197042 BMEI1331 Brucella melitensis bv. 1 str. 16M cytochrome C-type biogenesis protein CYCL precursor NP_540248.1 1386698 R 224914 CDS NP_540249.1 17987615 1197043 complement(1387171..1389162) 1 NC_003317.1 cytochrome C-type biogenesis protein CYCK 1389162 1197043 BMEI1332 Brucella melitensis bv. 1 str. 16M cytochrome C-type biogenesis protein CYCK NP_540249.1 1387171 R 224914 CDS NP_540250.1 17987616 1197044 complement(1389182..1389679) 1 NC_003317.1 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane; cytochrome c-type biogenesis protein CcmE 1389679 1197044 BMEI1333 Brucella melitensis bv. 1 str. 16M cytochrome c-type biogenesis protein CcmE NP_540250.1 1389182 R 224914 CDS NP_540251.1 17987617 1197045 complement(1389676..1390815) 1 NC_003317.1 cytochrome C-type biogenesis protein CYCH 1390815 1197045 BMEI1334 Brucella melitensis bv. 1 str. 16M cytochrome C-type biogenesis protein CYCH NP_540251.1 1389676 R 224914 CDS NP_540252.1 17987618 1197046 complement(1390916..1391311) 1 NC_003317.1 hypothetical protein 1391311 1197046 BMEI1335 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540252.1 1390916 R 224914 CDS NP_540253.1 17987619 1197047 complement(1391462..1392772) 1 NC_003317.1 sensor protein PHOQ 1392772 1197047 BMEI1336 Brucella melitensis bv. 1 str. 16M sensor protein PHOQ NP_540253.1 1391462 R 224914 CDS NP_540254.1 17987620 1197048 complement(1392847..1393536) 1 NC_003317.1 transcriptional regulatory protein PhoP 1393536 1197048 BMEI1337 Brucella melitensis bv. 1 str. 16M transcriptional regulatory protein PhoP NP_540254.1 1392847 R 224914 CDS NP_540255.1 17987621 1197049 complement(1393615..1393914) 1 NC_003317.1 hypothetical protein 1393914 1197049 BMEI1338 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540255.1 1393615 R 224914 CDS NP_540256.1 17987622 1197050 complement(1394073..1394384) 1 NC_003317.1 hypothetical protein 1394384 1197050 BMEI1339 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540256.1 1394073 R 224914 CDS NP_540257.1 17987623 1197051 complement(1394344..1395399) 1 NC_003317.1 Phage host specificity protein 1395399 1197051 BMEI1340 Brucella melitensis bv. 1 str. 16M Phage host specificity protein NP_540257.1 1394344 R 224914 CDS NP_540258.1 17987624 1197052 complement(1395389..1398118) 1 NC_003317.1 Phage host specificity protein 1398118 1197052 BMEI1341 Brucella melitensis bv. 1 str. 16M Phage host specificity protein NP_540258.1 1395389 R 224914 CDS NP_540259.1 17987625 1197053 complement(1398212..1398646) 1 NC_003317.1 hypothetical protein 1398646 1197053 BMEI1342 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540259.1 1398212 R 224914 CDS NP_540260.1 17987626 1197054 complement(1398643..1399518) 1 NC_003317.1 hypothetical protein 1399518 1197054 BMEI1343 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540260.1 1398643 R 224914 CDS NP_540261.1 17987627 1197055 complement(1399515..1400147) 1 NC_003317.1 hypothetical protein 1400147 1197055 BMEI1344 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540261.1 1399515 R 224914 CDS NP_540262.1 17987628 1197056 complement(1400150..1400719) 1 NC_003317.1 Phage minor tail protein H 1400719 1197056 BMEI1345 Brucella melitensis bv. 1 str. 16M Phage minor tail protein H NP_540262.1 1400150 R 224914 CDS NP_540263.1 17987629 1197057 complement(1400914..1401255) 1 NC_003317.1 hypothetical protein 1401255 1197057 BMEI1346 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540263.1 1400914 R 224914 CDS NP_540264.1 17987630 1197058 complement(1401252..1401665) 1 NC_003317.1 hypothetical protein 1401665 1197058 BMEI1347 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540264.1 1401252 R 224914 CDS NP_540265.1 17987631 1197059 complement(1401716..1402093) 1 NC_003317.1 hypothetical protein 1402093 1197059 BMEI1348 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540265.1 1401716 R 224914 CDS NP_540266.1 17987632 1197060 complement(1402090..1403283) 1 NC_003317.1 Phage portal protein 1403283 1197060 BMEI1349 Brucella melitensis bv. 1 str. 16M Phage portal protein NP_540266.1 1402090 R 224914 CDS NP_540267.1 17987633 1197061 complement(1403315..1404607) 1 NC_003317.1 Phage DNA packaging protein 1404607 1197061 BMEI1350 Brucella melitensis bv. 1 str. 16M Phage DNA packaging protein NP_540267.1 1403315 R 224914 CDS NP_540268.1 17987634 1197062 1405383..1407539 1 NC_003317.1 penicillin-binding protein 1A 1407539 1197062 BMEI1351 Brucella melitensis bv. 1 str. 16M penicillin-binding protein 1A NP_540268.1 1405383 D 224914 CDS NP_540269.1 17987635 1197063 1407576..1408157 1 NC_003317.1 hypothetical protein 1408157 1197063 BMEI1352 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540269.1 1407576 D 224914 CDS NP_540270.1 17987636 1197064 1408339..1408692 1 NC_003317.1 hypothetical protein 1408692 1197064 BMEI1353 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540270.1 1408339 D 224914 CDS NP_540271.1 17987637 1197065 1408890..1409948 1 NC_003317.1 hypothetical protein 1409948 1197065 BMEI1354 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540271.1 1408890 D 224914 CDS NP_540272.1 17987638 1197066 complement(1409959..1410306) 1 NC_003317.1 hypothetical protein 1410306 1197066 BMEI1355 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540272.1 1409959 R 224914 CDS NP_540273.1 17987639 1197067 complement(1410320..1411219) 1 NC_003317.1 peptidoglycan binding domain-containing protein 1411219 1197067 BMEI1356 Brucella melitensis bv. 1 str. 16M peptidoglycan binding domain-containing protein NP_540273.1 1410320 R 224914 CDS NP_540274.1 17987640 1197068 complement(1411263..1412570) 1 NC_003317.1 histidine protein kinase DIVJ 1412570 1197068 BMEI1357 Brucella melitensis bv. 1 str. 16M histidine protein kinase DIVJ NP_540274.1 1411263 R 224914 CDS NP_540275.1 17987641 1197069 1413383..1413847 1 NC_003317.1 hypothetical protein 1413847 1197069 BMEI1358 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540275.1 1413383 D 224914 CDS NP_540276.1 17987642 1197070 1413885..1414352 1 NC_003317.1 hypothetical protein 1414352 1197070 BMEI1359 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540276.1 1413885 D 224914 CDS NP_540277.2 161511133 1197071 complement(1414393..1415709) 1 NC_003317.1 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia; amidase 1415709 1197071 BMEI1360 Brucella melitensis bv. 1 str. 16M amidase NP_540277.2 1414393 R 224914 CDS NP_540278.1 17987644 1197072 complement(1415843..1416616) 1 NC_003317.1 hypothetical protein 1416616 1197072 BMEI1361 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540278.1 1415843 R 224914 CDS NP_540279.1 17987645 1197073 complement(1416613..1416969) 1 NC_003317.1 hypothetical protein 1416969 1197073 BMEI1362 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540279.1 1416613 R 224914 CDS NP_540280.1 17987646 1197074 1417250..1417561 1 NC_003317.1 hypothetical protein 1417561 1197074 BMEI1363 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540280.1 1417250 D 224914 CDS NP_540281.1 17987647 1197075 complement(1417769..1418254) 1 NC_003317.1 transcriptional regulatory protein MUCR 1418254 1197075 BMEI1364 Brucella melitensis bv. 1 str. 16M transcriptional regulatory protein MUCR NP_540281.1 1417769 R 224914 CDS NP_540282.1 17987648 1197076 1418770..1420878 1 NC_003317.1 oligopeptidase B 1420878 1197076 BMEI1365 Brucella melitensis bv. 1 str. 16M oligopeptidase B NP_540282.1 1418770 D 224914 CDS NP_540283.1 17987649 1197077 1420945..1421331 1 NC_003317.1 hypothetical protein 1421331 1197077 BMEI1366 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540283.1 1420945 D 224914 CDS NP_540284.1 17987650 1197078 complement(1421503..1422234) 1 NC_003317.1 superoxide dismutase (Mn) 1422234 1197078 BMEI1367 Brucella melitensis bv. 1 str. 16M superoxide dismutase (Mn) NP_540284.1 1421503 R 224914 CDS NP_540285.1 17987651 1197079 1422325..1423083 1 NC_003317.1 2-haloalkanoic acid dehalogenase 1423083 1197079 BMEI1368 Brucella melitensis bv. 1 str. 16M 2-haloalkanoic acid dehalogenase NP_540285.1 1422325 D 224914 CDS NP_540286.1 17987652 1197080 1423361..1423996 1 NC_003317.1 hypothetical protein 1423996 1197080 BMEI1369 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540286.1 1423361 D 224914 CDS NP_540287.1 17987653 1197081 complement(1424194..1425705) 1 NC_003317.1 ATPase 1425705 1197081 BMEI1370 Brucella melitensis bv. 1 str. 16M ATPase NP_540287.1 1424194 R 224914 CDS NP_540288.1 17987654 1197082 1425969..1426403 1 NC_003317.1 hypothetical protein 1426403 1197082 BMEI1371 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540288.1 1425969 D 224914 CDS NP_540289.1 17987655 1197083 complement(1426460..1427704) 1 NC_003317.1 cyanate transport protein CynX 1427704 1197083 BMEI1372 Brucella melitensis bv. 1 str. 16M cyanate transport protein CynX NP_540289.1 1426460 R 224914 CDS NP_540290.1 17987656 1197084 complement(1427755..1428432) 1 NC_003317.1 GntR family transcriptional regulator 1428432 1197084 BMEI1373 Brucella melitensis bv. 1 str. 16M GntR family transcriptional regulator NP_540290.1 1427755 R 224914 CDS NP_540291.1 17987657 1197085 1428588..1429580 1 NC_003317.1 magnesium/cobalt transporter CorA 1429580 1197085 BMEI1374 Brucella melitensis bv. 1 str. 16M magnesium/cobalt transporter CorA NP_540291.1 1428588 D 224914 CDS NP_540292.1 17987658 1197086 1429641..1429871 1 NC_003317.1 hypothetical protein 1429871 1197086 BMEI1375 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540292.1 1429641 D 224914 CDS NP_540293.1 17987659 1197087 1429868..1430257 1 NC_003317.1 death on curing protein 1430257 1197087 BMEI1376 Brucella melitensis bv. 1 str. 16M death on curing protein NP_540293.1 1429868 D 224914 CDS NP_540294.1 17987660 1197088 complement(1430254..1430724) 1 NC_003317.1 transcription elongation factor GREB 1430724 1197088 BMEI1377 Brucella melitensis bv. 1 str. 16M transcription elongation factor GREB NP_540294.1 1430254 R 224914 CDS NP_540295.1 17987661 1197089 complement(1430769..1431791) 1 NC_003317.1 L-asparaginase II 1431791 1197089 BMEI1378 Brucella melitensis bv. 1 str. 16M L-asparaginase II NP_540295.1 1430769 R 224914 CDS NP_540296.1 17987662 1197090 1431982..1432578 1 NC_003317.1 HTH-type; bet1; Repressor involved in choline regulation of the bet genes; transcriptional regulator BetI 1432578 1197090 BMEI1379 Brucella melitensis bv. 1 str. 16M transcriptional regulator BetI NP_540296.1 1431982 D 224914 CDS NP_540297.1 17987663 1197091 1432575..1434263 1 NC_003317.1 catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine; choline dehydrogenase 1434263 1197091 BMEI1380 Brucella melitensis bv. 1 str. 16M choline dehydrogenase NP_540297.1 1432575 D 224914 CDS NP_540298.1 17987664 1197092 1433816..1434229 1 NC_003317.1 choline dehydrogenase 1434229 1197092 BMEI1381 Brucella melitensis bv. 1 str. 16M choline dehydrogenase NP_540298.1 1433816 D 224914 CDS NP_540299.2 161511132 1197093 1434415..1435878 1 NC_003317.1 catalyzes the formation of betaine from betaine aldehyde; betaine aldehyde dehydrogenase 1435878 1197093 BMEI1382 Brucella melitensis bv. 1 str. 16M betaine aldehyde dehydrogenase NP_540299.2 1434415 D 224914 CDS NP_540300.1 17987666 1197094 1436447..1436986 1 NC_003317.1 AraC family transcriptional regulator 1436986 1197094 BMEI1383 Brucella melitensis bv. 1 str. 16M AraC family transcriptional regulator NP_540300.1 1436447 D 224914 CDS NP_540301.1 17987667 1197095 1436968..1437411 1 NC_003317.1 AraC family transcriptional regulator 1437411 1197095 BMEI1384 Brucella melitensis bv. 1 str. 16M AraC family transcriptional regulator NP_540301.1 1436968 D 224914 CDS NP_540302.1 17987668 1197096 1437673..1438704 1 NC_003317.1 LACI-family transcription regulator 1438704 1197096 BMEI1385 Brucella melitensis bv. 1 str. 16M LACI-family transcription regulator NP_540302.1 1437673 D 224914 CDS NP_540303.1 17987669 1197097 1438737..1440188 1 NC_003317.1 xylulose kinase 1440188 1197097 BMEI1386 Brucella melitensis bv. 1 str. 16M xylulose kinase NP_540303.1 1438737 D 224914 CDS NP_540304.1 17987670 1197098 1440235..1441542 1 NC_003317.1 catalyzes the interconversion of D-xylose to D-xylulose; xylose isomerase 1441542 1197098 BMEI1387 Brucella melitensis bv. 1 str. 16M xylose isomerase NP_540304.1 1440235 D 224914 CDS NP_540305.1 17987671 1197099 complement(1441584..1442756) 1 NC_003317.1 oxidoreductase 1442756 1197099 BMEI1388 Brucella melitensis bv. 1 str. 16M oxidoreductase NP_540305.1 1441584 R 224914 CDS NP_540306.1 17987672 1197100 complement(1442764..1443816) 1 NC_003317.1 sugar phosphate isomerase/epimerase IolE 1443816 1197100 BMEI1389 Brucella melitensis bv. 1 str. 16M sugar phosphate isomerase/epimerase IolE NP_540306.1 1442764 R 224914 CDS NP_540307.1 17987673 1197101 complement(1443874..1444800) 1 NC_003317.1 D-ribose-binding periplasmic protein precursor 1444800 1197101 BMEI1390 Brucella melitensis bv. 1 str. 16M D-ribose-binding periplasmic protein precursor NP_540307.1 1443874 R 224914 CDS NP_540308.1 17987674 1197102 complement(1444915..1445940) 1 NC_003317.1 ribose ABC transporter permease 1445940 1197102 BMEI1391 Brucella melitensis bv. 1 str. 16M ribose ABC transporter permease NP_540308.1 1444915 R 224914 CDS NP_540309.1 17987675 1197103 complement(1445937..1447505) 1 NC_003317.1 ribose ABC transporter ATP-binding protein 1447505 1197103 BMEI1392 Brucella melitensis bv. 1 str. 16M ribose ABC transporter ATP-binding protein NP_540309.1 1445937 R 224914 CDS NP_540310.1 17987676 1197104 complement(1448164..1449297) 1 NC_003317.1 mannosyltransferase 1449297 1197104 BMEI1393 Brucella melitensis bv. 1 str. 16M mannosyltransferase NP_540310.1 1448164 R 224914 CDS NP_540311.1 17987677 1197105 complement(1449356..1450519) 1 NC_003317.1 mannose-6-phosphate isomerase 1450519 1197105 BMEI1394 Brucella melitensis bv. 1 str. 16M mannose-6-phosphate isomerase NP_540311.1 1449356 R 224914 CDS NP_540312.1 17987678 1197106 complement(1450561..1451985) 1 NC_003317.1 mannose-1-phosphate guanylyltransferase 1451985 1197106 BMEI1395 Brucella melitensis bv. 1 str. 16M mannose-1-phosphate guanylyltransferase NP_540312.1 1450561 R 224914 CDS NP_540313.1 17987679 1197107 complement(1452056..1453429) 1 NC_003317.1 phosphomannomutase 1453429 1197107 BMEI1396 Brucella melitensis bv. 1 str. 16M phosphomannomutase NP_540313.1 1452056 R 224914 CDS NP_540314.1 17987680 1197108 complement(1453577..1453930) 1 NC_003317.1 transposase 1453930 1197108 BMEI1397 Brucella melitensis bv. 1 str. 16M transposase NP_540314.1 1453577 R 224914 CDS NP_540315.1 17987681 1197109 complement(1454236..1454652) 1 NC_003317.1 transposase 1454652 1197109 BMEI1398 Brucella melitensis bv. 1 str. 16M transposase NP_540315.1 1454236 R 224914 CDS NP_540316.1 17987682 1197110 complement(1454571..1454879) 1 NC_003317.1 transposase 1454879 1197110 BMEI1399 Brucella melitensis bv. 1 str. 16M transposase NP_540316.1 1454571 R 224914 CDS NP_540317.1 17987683 1197111 complement(1454723..1454998) 1 NC_003317.1 transposase 1454998 1197111 BMEI1400 Brucella melitensis bv. 1 str. 16M transposase NP_540317.1 1454723 R 224914 CDS NP_540318.1 17987684 1197112 1455163..1455717 1 NC_003317.1 transposase 1455717 1197112 BMEI1401 Brucella melitensis bv. 1 str. 16M transposase NP_540318.1 1455163 D 224914 CDS NP_540319.1 17987685 1197113 complement(1455807..1456247) 1 NC_003317.1 transposase 1456247 1197113 BMEI1402 Brucella melitensis bv. 1 str. 16M transposase NP_540319.1 1455807 R 224914 CDS NP_540320.1 17987686 1197114 complement(1456244..1456612) 1 NC_003317.1 transposase 1456612 1197114 BMEI1403 Brucella melitensis bv. 1 str. 16M transposase NP_540320.1 1456244 R 224914 CDS NP_540321.1 17987687 1197115 complement(1456670..1457788) 1 NC_003317.1 mannosyltransferase 1457788 1197115 BMEI1404 Brucella melitensis bv. 1 str. 16M mannosyltransferase NP_540321.1 1456670 R 224914 CDS NP_540322.1 17987688 1197116 complement(1457919..1458158) 1 NC_003317.1 transposase 1458158 1197116 BMEI1405 Brucella melitensis bv. 1 str. 16M transposase NP_540322.1 1457919 R 224914 CDS NP_540323.1 17987689 1197117 complement(1458274..1458552) 1 NC_003317.1 transposase 1458552 1197117 BMEI1406 Brucella melitensis bv. 1 str. 16M transposase NP_540323.1 1458274 R 224914 CDS NP_540324.1 17987690 1197118 complement(1458549..1458917) 1 NC_003317.1 transposase 1458917 1197118 BMEI1407 Brucella melitensis bv. 1 str. 16M transposase NP_540324.1 1458549 R 224914 CDS NP_540325.1 17987691 1197119 complement(1458987..1459397) 1 NC_003317.1 transposase 1459397 1197119 BMEI1408 Brucella melitensis bv. 1 str. 16M transposase NP_540325.1 1458987 R 224914 CDS NP_540326.1 17987692 1197120 complement(1459394..1459780) 1 NC_003317.1 transposase 1459780 1197120 BMEI1409 Brucella melitensis bv. 1 str. 16M transposase NP_540326.1 1459394 R 224914 CDS NP_540327.1 17987693 1197121 complement(1459810..1460184) 1 NC_003317.1 transposase 1460184 1197121 BMEI1410 Brucella melitensis bv. 1 str. 16M transposase NP_540327.1 1459810 R 224914 CDS NP_540328.1 17987694 1197122 complement(1460103..1460411) 1 NC_003317.1 transposase 1460411 1197122 BMEI1411 Brucella melitensis bv. 1 str. 16M transposase NP_540328.1 1460103 R 224914 CDS NP_540329.1 17987695 1197123 complement(1460255..1460530) 1 NC_003317.1 transposase 1460530 1197123 BMEI1412 Brucella melitensis bv. 1 str. 16M transposase NP_540329.1 1460255 R 224914 CDS NP_540330.1 17987696 1197124 1461049..1462137 1 NC_003317.1 GDP-mannose 4,6-dehydratase 1462137 1197124 BMEI1413 Brucella melitensis bv. 1 str. 16M GDP-mannose 4,6-dehydratase NP_540330.1 1461049 D 224914 CDS NP_540331.1 17987697 1197125 1462106..1463248 1 NC_003317.1 perosamine synthetase 1463248 1197125 BMEI1414 Brucella melitensis bv. 1 str. 16M perosamine synthetase NP_540331.1 1462106 D 224914 CDS NP_540332.1 17987698 1197126 1463248..1464045 1 NC_003317.1 O-antigen export system permease protein RFBD 1464045 1197126 BMEI1415 Brucella melitensis bv. 1 str. 16M O-antigen export system permease protein RFBD NP_540332.1 1463248 D 224914 CDS NP_540333.1 17987699 1197127 1464042..1464800 1 NC_003317.1 O-antigen export system ATP-binding protein RFBB 1464800 1197127 BMEI1416 Brucella melitensis bv. 1 str. 16M O-antigen export system ATP-binding protein RFBB NP_540333.1 1464042 D 224914 CDS NP_540334.1 17987700 1197128 1464797..1465651 1 NC_003317.1 perosamine synthetase WbkB 1465651 1197128 BMEI1417 Brucella melitensis bv. 1 str. 16M perosamine synthetase WbkB NP_540334.1 1464797 D 224914 CDS NP_540335.1 17987701 1197129 1465678..1466457 1 NC_003317.1 GDP-mannose 4,6-dehydratase 1466457 1197129 BMEI1418 Brucella melitensis bv. 1 str. 16M GDP-mannose 4,6-dehydratase NP_540335.1 1465678 D 224914 CDS NP_540336.1 17987702 1197130 complement(1466586..1466729) 1 NC_003317.1 hypothetical protein 1466729 1197130 BMEI1419 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540336.1 1466586 R 224914 CDS NP_540337.1 17987703 1197131 complement(1466793..1467656) 1 NC_003317.1 transposase 1467656 1197131 BMEI1420 Brucella melitensis bv. 1 str. 16M transposase NP_540337.1 1466793 R 224914 CDS NP_540338.1 17987704 1197132 complement(1467885..1468115) 1 NC_003317.1 transposase 1468115 1197132 BMEI1421 Brucella melitensis bv. 1 str. 16M transposase NP_540338.1 1467885 R 224914 CDS NP_540339.1 17987705 1197133 complement(1468172..1468471) 1 NC_003317.1 transposase 1468471 1197133 BMEI1422 Brucella melitensis bv. 1 str. 16M transposase NP_540339.1 1468172 R 224914 CDS NP_540340.1 17987706 1197134 complement(1468528..1469181) 1 NC_003317.1 transposase 1469181 1197134 BMEI1423 Brucella melitensis bv. 1 str. 16M transposase NP_540340.1 1468528 R 224914 CDS NP_540341.1 17987707 1197135 complement(1468847..1469665) 1 NC_003317.1 transposase 1469665 1197135 BMEI1424 Brucella melitensis bv. 1 str. 16M transposase NP_540341.1 1468847 R 224914 CDS NP_540342.1 17987708 1197136 1469933..1470058 1 NC_003317.1 hypothetical protein 1470058 1197136 BMEI1425 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540342.1 1469933 D 224914 CDS NP_540343.1 17987709 1197137 1470324..1471331 1 NC_003317.1 undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase 1471331 1197137 BMEI1426 Brucella melitensis bv. 1 str. 16M undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase NP_540343.1 1470324 D 224914 CDS NP_540344.1 17987710 1197138 complement(1471318..1473186) 1 NC_003317.1 capsular polysaccharide biosynthesis protein CapD 1473186 1197138 BMEI1427 Brucella melitensis bv. 1 str. 16M capsular polysaccharide biosynthesis protein CapD NP_540344.1 1471318 R 224914 CDS NP_540345.1 17987711 1197139 complement(1473723..1474559) 1 NC_003317.1 ribonuclease III 1474559 1197139 BMEI1428 Brucella melitensis bv. 1 str. 16M ribonuclease III NP_540345.1 1473723 R 224914 CDS NP_540346.1 17987712 1197140 complement(1474630..1475001) 1 NC_003317.1 transthyretin-like protein 1475001 1197140 BMEI1429 Brucella melitensis bv. 1 str. 16M transthyretin-like protein NP_540346.1 1474630 R 224914 CDS NP_540347.1 17987713 1197141 complement(1474998..1475507) 1 NC_003317.1 catalyzes the formation of glyoxylate from (S)-ureidoglycolate; ureidoglycolate hydrolase 1475507 1197141 BMEI1430 Brucella melitensis bv. 1 str. 16M ureidoglycolate hydrolase NP_540347.1 1474998 R 224914 CDS NP_540348.1 17987714 1197142 complement(1475643..1476242) 1 NC_003317.1 BioY protein 1476242 1197142 BMEI1431 Brucella melitensis bv. 1 str. 16M BioY protein NP_540348.1 1475643 R 224914 CDS NP_540349.1 17987715 1197143 1476428..1477348 1 NC_003317.1 hydroxyacylglutathione hydrolase 1477348 1197143 BMEI1432 Brucella melitensis bv. 1 str. 16M hydroxyacylglutathione hydrolase NP_540349.1 1476428 D 224914 CDS NP_540350.1 17987716 1197144 complement(1477349..1478137) 1 NC_003317.1 hypothetical protein 1478137 1197144 BMEI1433 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540350.1 1477349 R 224914 CDS NP_540351.1 17987717 1197145 1478446..1478895 1 NC_003317.1 hypothetical protein 1478895 1197145 BMEI1434 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540351.1 1478446 D 224914 CDS NP_540352.1 17987718 1197146 complement(1479098..1479847) 1 NC_003317.1 polysaccharide deacetylase 1479847 1197146 BMEI1435 Brucella melitensis bv. 1 str. 16M polysaccharide deacetylase NP_540352.1 1479098 R 224914 CDS NP_540353.1 17987719 1197147 complement(1480130..1482922) 1 NC_003317.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate phosphate dikinase 1482922 1197147 BMEI1436 Brucella melitensis bv. 1 str. 16M pyruvate phosphate dikinase NP_540353.1 1480130 R 224914 CDS NP_540354.1 17987720 1197148 1483033..1483398 1 NC_003317.1 hydroxlase 1483398 1197148 BMEI1437 Brucella melitensis bv. 1 str. 16M hydroxlase NP_540354.1 1483033 D 224914 CDS NP_540355.1 17987721 1197149 complement(1483508..1484413) 1 NC_003317.1 cobalt-zinc-cadmium resistance protein CZCD 1484413 1197149 BMEI1438 Brucella melitensis bv. 1 str. 16M cobalt-zinc-cadmium resistance protein CZCD NP_540355.1 1483508 R 224914 CDS NP_540356.1 17987722 1197150 complement(1484424..1487888) 1 NC_003317.1 chromosome segregation protein SMC2 1487888 1197150 BMEI1439 Brucella melitensis bv. 1 str. 16M chromosome segregation protein SMC2 NP_540356.1 1484424 R 224914 CDS NP_540357.1 17987723 1197151 complement(1487961..1488614) 1 NC_003317.1 thiol:disulfide interchange protein DsbA 1488614 1197151 BMEI1440 Brucella melitensis bv. 1 str. 16M thiol:disulfide interchange protein DsbA NP_540357.1 1487961 R 224914 CDS NP_540358.1 17987724 1197152 complement(1488852..1489379) 1 NC_003317.1 hypothetical protein 1489379 1197152 BMEI1441 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540358.1 1488852 R 224914 CDS NP_540359.1 17987725 1197153 1489602..1490729 1 NC_003317.1 A/G-specific adenine glycosylase 1490729 1197153 BMEI1442 Brucella melitensis bv. 1 str. 16M A/G-specific adenine glycosylase NP_540359.1 1489602 D 224914 CDS NP_540360.1 17987726 1197154 1490726..1491343 1 NC_003317.1 2-haloalkanoic acid dehalogenase 1491343 1197154 BMEI1443 Brucella melitensis bv. 1 str. 16M 2-haloalkanoic acid dehalogenase NP_540360.1 1490726 D 224914 CDS NP_540361.1 17987727 1197155 complement(1491426..1492637) 1 NC_003317.1 adenine-specific methyltransferase 1492637 1197155 BMEI1444 Brucella melitensis bv. 1 str. 16M adenine-specific methyltransferase NP_540361.1 1491426 R 224914 CDS NP_540362.1 17987728 1197156 1492935..1494602 1 NC_003317.1 chloride channel protein 1494602 1197156 BMEI1445 Brucella melitensis bv. 1 str. 16M chloride channel protein NP_540362.1 1492935 D 224914 CDS NP_540363.1 17987729 1197157 1494663..1495436 1 NC_003317.1 phosphoglycolate phosphatase 1495436 1197157 BMEI1446 Brucella melitensis bv. 1 str. 16M phosphoglycolate phosphatase NP_540363.1 1494663 D 224914 CDS NP_540364.1 17987730 1197158 complement(1495478..1495663) 1 NC_003317.1 hypothetical protein 1495663 1197158 BMEI1447 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540364.1 1495478 R 224914 CDS NP_540365.1 17987731 1197159 complement(1495792..1497372) 1 NC_003317.1 c-di-GMP phosphodiesterase A-related protein 1497372 1197159 BMEI1448 Brucella melitensis bv. 1 str. 16M c-di-GMP phosphodiesterase A-related protein NP_540365.1 1495792 R 224914 CDS NP_540366.1 17987732 1197160 complement(1497740..1498264) 1 NC_003317.1 hypothetical protein 1498264 1197160 BMEI1449 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540366.1 1497740 R 224914 CDS NP_540367.1 17987733 1197161 1498740..1500131 1 NC_003317.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 1500131 1197161 BMEI1450 Brucella melitensis bv. 1 str. 16M threonine synthase NP_540367.1 1498740 D 224914 CDS NP_540368.1 17987734 1197162 1500005..1501477 1 NC_003317.1 processing peptidase 1501477 1197162 BMEI1451 Brucella melitensis bv. 1 str. 16M processing peptidase NP_540368.1 1500005 D 224914 CDS NP_540369.1 17987735 1197163 1501648..1502268 1 NC_003317.1 ribosomal-protein-alanine acetyltransferase 1502268 1197163 BMEI1452 Brucella melitensis bv. 1 str. 16M ribosomal-protein-alanine acetyltransferase NP_540369.1 1501648 D 224914 CDS NP_540370.1 17987736 1197164 1502265..1505159 1 NC_003317.1 diguanylate cyclase/phosphodiesterase 1505159 1197164 BMEI1453 Brucella melitensis bv. 1 str. 16M diguanylate cyclase/phosphodiesterase NP_540370.1 1502265 D 224914 CDS NP_540371.2 161511131 1197165 complement(1505281..1505883) 1 NC_003317.1 hypothetical protein 1505883 1197165 BMEI1454 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540371.2 1505281 R 224914 CDS NP_540372.1 17987738 1197166 1506018..1506818 1 NC_003317.1 THIO:disulfide interchange protein 1506818 1197166 BMEI1455 Brucella melitensis bv. 1 str. 16M THIO:disulfide interchange protein NP_540372.1 1506018 D 224914 CDS NP_540373.1 17987739 1197167 1506908..1507483 1 NC_003317.1 thiol peroxidase 1507483 1197167 BMEI1456 Brucella melitensis bv. 1 str. 16M thiol peroxidase NP_540373.1 1506908 D 224914 CDS NP_540374.1 17987740 1197168 complement(1507514..1507978) 1 NC_003317.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease H 1507978 rnhA 1197168 rnhA Brucella melitensis bv. 1 str. 16M ribonuclease H NP_540374.1 1507514 R 224914 CDS NP_540375.1 17987741 1197169 complement(1507975..1508955) 1 NC_003317.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine; homoserine kinase 1508955 1197169 BMEI1458 Brucella melitensis bv. 1 str. 16M homoserine kinase NP_540375.1 1507975 R 224914 CDS NP_540376.2 161511130 1197170 complement(1508961..1510079) 1 NC_003317.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1510079 ispH 1197170 ispH Brucella melitensis bv. 1 str. 16M 4-hydroxy-3-methylbut-2-enyl diphosphate reductase NP_540376.2 1508961 R 224914 CDS NP_540377.1 17987743 1197171 complement(1510110..1510859) 1 NC_003317.1 surfeit locus protein 1 1510859 1197171 BMEI1460 Brucella melitensis bv. 1 str. 16M surfeit locus protein 1 NP_540377.1 1510110 R 224914 CDS NP_540378.1 17987744 1197172 complement(1510856..1511314) 1 NC_003317.1 zinc-finger protein 1511314 1197172 BMEI1461 Brucella melitensis bv. 1 str. 16M zinc-finger protein NP_540378.1 1510856 R 224914 CDS NP_540379.1 17987745 1197173 complement(1511353..1512297) 1 NC_003317.1 cytochrome c oxidase polypeptide III 1512297 1197173 BMEI1462 Brucella melitensis bv. 1 str. 16M cytochrome c oxidase polypeptide III NP_540379.1 1511353 R 224914 CDS NP_540380.1 17987746 1197174 complement(1512440..1513153) 1 NC_003317.1 involved in the insertion of copper into subunit I of cytochrome C oxidase; cytochrome C oxidase assembly protein 1513153 1197174 BMEI1463 Brucella melitensis bv. 1 str. 16M cytochrome C oxidase assembly protein NP_540380.1 1512440 R 224914 CDS NP_540381.1 17987747 1197175 complement(1513250..1514197) 1 NC_003317.1 converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase 1514197 1197175 BMEI1464 Brucella melitensis bv. 1 str. 16M protoheme IX farnesyltransferase NP_540381.1 1513250 R 224914 CDS NP_540382.1 17987748 1197176 complement(1514425..1516083) 1 NC_003317.1 cytochrome C oxidase polypeptide I 1516083 1197176 BMEI1465 Brucella melitensis bv. 1 str. 16M cytochrome C oxidase polypeptide I NP_540382.1 1514425 R 224914 CDS NP_540383.1 17987749 1197177 complement(1516221..1517183) 1 NC_003317.1 cytochrome c oxidase polypeptide II 1517183 1197177 BMEI1466 Brucella melitensis bv. 1 str. 16M cytochrome c oxidase polypeptide II NP_540383.1 1516221 R 224914 CDS NP_540384.1 17987750 1197178 1517539..1518135 1 NC_003317.1 hypothetical protein 1518135 1197178 BMEI1467 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540384.1 1517539 D 224914 CDS NP_540385.1 17987751 1197179 1518276..1519688 1 NC_003317.1 TLDD protein 1519688 1197179 BMEI1468 Brucella melitensis bv. 1 str. 16M TLDD protein NP_540385.1 1518276 D 224914 CDS NP_540386.2 161511129 1197180 complement(1519715..1520377) 1 NC_003317.1 Essential for recycling GMP and indirectly, cGMP; guanylate kinase 1520377 gmk 1197180 gmk Brucella melitensis bv. 1 str. 16M guanylate kinase NP_540386.2 1519715 R 224914 CDS NP_540387.1 17987753 1197181 complement(1520386..1521330) 1 NC_003317.1 hypothetical protein 1521330 1197181 BMEI1470 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540387.1 1520386 R 224914 CDS NP_540388.1 17987754 1197182 complement(1521469..1522707) 1 NC_003317.1 4-amino-4-deoxychorismate lyase 1522707 1197182 BMEI1471 Brucella melitensis bv. 1 str. 16M 4-amino-4-deoxychorismate lyase NP_540388.1 1521469 R 224914 CDS NP_540389.1 17987755 1197183 1522726..1522944 1 NC_003317.1 hypothetical protein 1522944 1197183 BMEI1472 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540389.1 1522726 D 224914 CDS NP_540390.1 17987756 1197184 complement(1522932..1524194) 1 NC_003317.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 1524194 1197184 BMEI1473 Brucella melitensis bv. 1 str. 16M 3-oxoacyl-ACP synthase NP_540390.1 1522932 R 224914 CDS NP_540391.1 17987757 1197185 complement(1524251..1524514) 1 NC_003317.1 hypothetical protein 1524514 1197185 BMEI1474 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540391.1 1524251 R 224914 CDS NP_540392.1 17987758 1197186 complement(1524518..1524754) 1 NC_003317.1 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 1524754 acpP 1197186 acpP Brucella melitensis bv. 1 str. 16M acyl carrier protein NP_540392.1 1524518 R 224914 CDS NP_540393.1 17987759 1197187 1524769..1524993 1 NC_003317.1 hypothetical protein 1524993 1197187 BMEI1476 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540393.1 1524769 D 224914 CDS NP_540394.1 17987760 1197188 complement(1525028..1525765) 1 NC_003317.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 1525765 fabG 1197188 fabG Brucella melitensis bv. 1 str. 16M 3-ketoacyl-ACP reductase NP_540394.1 1525028 R 224914 CDS NP_540395.1 17987761 1197189 complement(1525835..1526779) 1 NC_003317.1 ACP S-malonyltransferase 1526779 1197189 BMEI1478 Brucella melitensis bv. 1 str. 16M ACP S-malonyltransferase NP_540395.1 1525835 R 224914 CDS NP_540396.1 17987762 1197190 1526801..1527160 1 NC_003317.1 hypothetical protein 1527160 1197190 BMEI1479 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540396.1 1526801 D 224914 CDS NP_540397.1 17987763 1197191 1527185..1527631 1 NC_003317.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 1527631 rpsF 1197191 rpsF Brucella melitensis bv. 1 str. 16M 30S ribosomal protein S6 NP_540397.1 1527185 D 224914 CDS NP_540398.1 17987764 1197192 1527634..1527882 1 NC_003317.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 1527882 rpsR 1197192 rpsR Brucella melitensis bv. 1 str. 16M 30S ribosomal protein S18 NP_540398.1 1527634 D 224914 CDS NP_540399.1 17987765 1197193 1528033..1529004 1 NC_003317.1 hypothetical protein 1529004 1197193 BMEI1482 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540399.1 1528033 D 224914 CDS NP_540400.1 17987766 1197194 1529034..1529603 1 NC_003317.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 1529603 rplI 1197194 rplI Brucella melitensis bv. 1 str. 16M 50S ribosomal protein L9 NP_540400.1 1529034 D 224914 CDS NP_540401.1 17987767 1197195 1529933..1531258 1 NC_003317.1 cyclopropane-fatty-acyl-phospholipid synthase 1531258 1197195 BMEI1484 Brucella melitensis bv. 1 str. 16M cyclopropane-fatty-acyl-phospholipid synthase NP_540401.1 1529933 D 224914 CDS NP_540402.1 17987768 1197196 1531457..1532962 1 NC_003317.1 unwinds double stranded DNA; replicative DNA helicase 1532962 1197196 BMEI1485 Brucella melitensis bv. 1 str. 16M replicative DNA helicase NP_540402.1 1531457 D 224914 CDS NP_540403.1 17987769 1197197 1532990..1534393 1 NC_003317.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 1534393 1197197 BMEI1486 Brucella melitensis bv. 1 str. 16M DNA repair protein RadA NP_540403.1 1532990 D 224914 CDS NP_540404.1 17987770 1197198 1534519..1535097 1 NC_003317.1 colicin V production protein 1535097 1197198 BMEI1487 Brucella melitensis bv. 1 str. 16M colicin V production protein NP_540404.1 1534519 D 224914 CDS NP_540405.1 17987771 1197199 1535319..1536869 1 NC_003317.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 1536869 1197199 BMEI1488 Brucella melitensis bv. 1 str. 16M amidophosphoribosyltransferase NP_540405.1 1535319 D 224914 CDS NP_540406.1 17987772 1197200 1536911..1537678 1 NC_003317.1 ribitol-5-phosphate dehydrogenase [NADP('+)] 1537678 1197200 BMEI1489 Brucella melitensis bv. 1 str. 16M ribitol-5-phosphate dehydrogenase [NADP('+)] NP_540406.1 1536911 D 224914 CDS NP_540407.1 17987773 1197201 complement(1537763..1538644) 1 NC_003317.1 CDP-diacylglycerol--serine O-phosphatidyltransferase 1538644 1197201 BMEI1490 Brucella melitensis bv. 1 str. 16M CDP-diacylglycerol--serine O-phosphatidyltransferase NP_540407.1 1537763 R 224914 CDS NP_540408.2 161511128 1197202 complement(1538604..1539302) 1 NC_003317.1 catalyzes the decarboxylaton of phospatidyl-L-sering to phosphatidylethanolamine; phosphatidylserine decarboxylase 1539302 1197202 BMEI1491 Brucella melitensis bv. 1 str. 16M phosphatidylserine decarboxylase NP_540408.2 1538604 R 224914 CDS NP_540409.1 17987775 1197203 complement(1539407..1541293) 1 NC_003317.1 heavy metal tolerance protein 1541293 1197203 BMEI1492 Brucella melitensis bv. 1 str. 16M heavy metal tolerance protein NP_540409.1 1539407 R 224914 CDS NP_540410.1 17987776 1197204 complement(1541496..1542491) 1 NC_003317.1 peptidoglycan binding protein 1542491 1197204 BMEI1493 Brucella melitensis bv. 1 str. 16M peptidoglycan binding protein NP_540410.1 1541496 R 224914 CDS NP_540411.1 17987777 1197205 complement(1542897..1543238) 1 NC_003317.1 hypothetical protein 1543238 1197205 BMEI1494 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540411.1 1542897 R 224914 CDS NP_540412.1 17987778 1197206 1543329..1543994 1 NC_003317.1 lysine decarboxylase 1543994 1197206 BMEI1495 Brucella melitensis bv. 1 str. 16M lysine decarboxylase NP_540412.1 1543329 D 224914 CDS NP_540413.1 17987779 1197207 complement(1544098..1545345) 1 NC_003317.1 tRNA (uracil-5-) -methyltransferase 1545345 1197207 BMEI1496 Brucella melitensis bv. 1 str. 16M tRNA (uracil-5-) -methyltransferase NP_540413.1 1544098 R 224914 CDS NP_540414.1 17987780 1197208 complement(1545342..1546103) 1 NC_003317.1 hemolysin 1546103 1197208 BMEI1497 Brucella melitensis bv. 1 str. 16M hemolysin NP_540414.1 1545342 R 224914 CDS NP_540415.1 17987781 1197209 complement(1546109..1548040) 1 NC_003317.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 1548040 1197209 BMEI1498 Brucella melitensis bv. 1 str. 16M 1-deoxy-D-xylulose-5-phosphate synthase NP_540415.1 1546109 R 224914 CDS NP_540416.1 17987782 1197210 complement(1548183..1549130) 1 NC_003317.1 pirin 1549130 1197210 BMEI1499 Brucella melitensis bv. 1 str. 16M pirin NP_540416.1 1548183 R 224914 CDS NP_540417.1 17987783 1197211 complement(1549259..1549513) 1 NC_003317.1 hypothetical protein 1549513 1197211 BMEI1500 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540417.1 1549259 R 224914 CDS NP_540418.1 17987784 1197212 1549973..1550233 1 NC_003317.1 transglycosylase associated protein 1550233 1197212 BMEI1501 Brucella melitensis bv. 1 str. 16M transglycosylase associated protein NP_540418.1 1549973 D 224914 CDS NP_540419.1 17987785 1197213 1550400..1550993 1 NC_003317.1 alkaline phosphatase 1550993 1197213 BMEI1502 Brucella melitensis bv. 1 str. 16M alkaline phosphatase NP_540419.1 1550400 D 224914 CDS NP_540420.1 17987786 1197214 complement(1551000..1551251) 1 NC_003317.1 catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 1551251 1197214 BMEI1503 Brucella melitensis bv. 1 str. 16M exodeoxyribonuclease VII small subunit NP_540420.1 1551000 R 224914 CDS NP_540421.1 17987787 1197215 complement(1551259..1552272) 1 NC_003317.1 acetylspermidine deacetylase 1552272 1197215 BMEI1504 Brucella melitensis bv. 1 str. 16M acetylspermidine deacetylase NP_540421.1 1551259 R 224914 CDS NP_540422.1 17987788 1197216 complement(1552425..1553540) 1 NC_003317.1 GTP cyclohydrolase II 1553540 1197216 BMEI1505 Brucella melitensis bv. 1 str. 16M GTP cyclohydrolase II NP_540422.1 1552425 R 224914 CDS NP_540423.1 17987789 1197217 complement(1553676..1554770) 1 NC_003317.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 1554770 1197217 BMEI1506 Brucella melitensis bv. 1 str. 16M chorismate synthase NP_540423.1 1553676 R 224914 CDS NP_540424.1 17987790 1197218 1555044..1555295 1 NC_003317.1 hypothetical protein 1555295 1197218 BMEI1507 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540424.1 1555044 D 224914 CDS NP_540425.1 17987791 1197219 complement(1555440..1556117) 1 NC_003317.1 lipoprotein 1556117 1197219 BMEI1508 Brucella melitensis bv. 1 str. 16M lipoprotein NP_540425.1 1555440 R 224914 CDS NP_540426.1 17987792 1197220 complement(1556194..1556406) 1 NC_003317.1 hypothetical protein 1556406 1197220 BMEI1509 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540426.1 1556194 R 224914 CDS NP_540427.1 17987793 1197221 complement(1556876..1557085) 1 NC_003317.1 cold shock protein CSPA 1557085 1197221 BMEI1510 Brucella melitensis bv. 1 str. 16M cold shock protein CSPA NP_540427.1 1556876 R 224914 CDS NP_540428.1 17987794 1197222 complement(1557347..1557937) 1 NC_003317.1 phosphoglycerate mutase/fructose-2,6-bisphosphatase 1557937 1197222 BMEI1511 Brucella melitensis bv. 1 str. 16M phosphoglycerate mutase/fructose-2,6-bisphosphatase NP_540428.1 1557347 R 224914 CDS NP_540429.1 17987795 1197223 complement(1558052..1558870) 1 NC_003317.1 Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-ACP reductase 1558870 1197223 BMEI1512 Brucella melitensis bv. 1 str. 16M enoyl-ACP reductase NP_540429.1 1558052 R 224914 CDS NP_540430.1 17987796 1197224 complement(1559014..1559955) 1 NC_003317.1 molecular chaperone DnaJ 1559955 1197224 BMEI1513 Brucella melitensis bv. 1 str. 16M molecular chaperone DnaJ NP_540430.1 1559014 R 224914 CDS NP_540431.1 17987797 1197225 complement(1560048..1560398) 1 NC_003317.1 hypothetical protein 1560398 1197225 BMEI1514 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540431.1 1560048 R 224914 CDS NP_540432.1 17987798 1197226 complement(1560100..1560306) 1 NC_003317.1 hypothetical protein 1560306 1197226 BMEI1515 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540432.1 1560100 R 224914 CDS NP_540433.1 17987799 1197227 1560393..1560641 1 NC_003317.1 hypothetical protein 1560641 1197227 BMEI1516 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540433.1 1560393 D 224914 CDS NP_540434.1 17987800 1197228 1560828..1561454 1 NC_003317.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; pyridoxamine 5'-phosphate oxidase 1561454 1197228 BMEI1517 Brucella melitensis bv. 1 str. 16M pyridoxamine 5'-phosphate oxidase NP_540434.1 1560828 D 224914 CDS NP_540435.1 17987801 1197229 complement(1561494..1562495) 1 NC_003317.1 UbiA prenyltransferase family catalyzes the transfer of a prenyl group to various acceptors with hydrophobic ring structures in the biosynthesis of respiratory quinones, hemes, chlorophylls, vitamin E, and shikonin; 4-hydroxybenzoate polyprenyltransferase 1562495 ubiA 1197229 ubiA Brucella melitensis bv. 1 str. 16M 4-hydroxybenzoate polyprenyltransferase NP_540435.1 1561494 R 224914 CDS NP_540436.1 17987802 1197230 1562640..1563923 1 NC_003317.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 1563923 1197230 BMEI1519 Brucella melitensis bv. 1 str. 16M phosphoribosylamine--glycine ligase NP_540436.1 1562640 D 224914 CDS NP_540437.1 17987803 1197231 complement(1563941..1565008) 1 NC_003317.1 response regulator protein 1565008 1197231 BMEI1520 Brucella melitensis bv. 1 str. 16M response regulator protein NP_540437.1 1563941 R 224914 CDS NP_540438.1 17987804 1197232 1565404..1567182 1 NC_003317.1 acyl-CoA dehydrogenase 1567182 1197232 BMEI1521 Brucella melitensis bv. 1 str. 16M acyl-CoA dehydrogenase NP_540438.1 1565404 D 224914 CDS NP_540439.1 17987805 1197233 1567074..1567937 1 NC_003317.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 1567937 1197233 BMEI1522 Brucella melitensis bv. 1 str. 16M enoyl-CoA hydratase NP_540439.1 1567074 D 224914 CDS NP_540440.1 17987806 1197234 complement(1568080..1568643) 1 NC_003317.1 hypothetical protein 1568643 1197234 BMEI1523 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540440.1 1568080 R 224914 CDS NP_540441.1 17987807 1197235 1568636..1568848 1 NC_003317.1 hypothetical protein 1568848 1197235 BMEI1524 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540441.1 1568636 D 224914 CDS NP_540442.1 17987808 1197236 1568957..1569217 1 NC_003317.1 CopG family transcriptional regulator 1569217 1197236 BMEI1525 Brucella melitensis bv. 1 str. 16M CopG family transcriptional regulator NP_540442.1 1568957 D 224914 CDS NP_540443.1 17987809 1197237 1569214..1569531 1 NC_003317.1 hypothetical protein 1569531 1197237 BMEI1526 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540443.1 1569214 D 224914 CDS NP_540444.1 17987810 1197238 complement(1569569..1570981) 1 NC_003317.1 glycolate oxidase subunit GLCD 1570981 1197238 BMEI1527 Brucella melitensis bv. 1 str. 16M glycolate oxidase subunit GLCD NP_540444.1 1569569 R 224914 CDS NP_540445.1 17987811 1197239 complement(1571007..1571978) 1 NC_003317.1 SUA5 protein 1571978 1197239 BMEI1528 Brucella melitensis bv. 1 str. 16M SUA5 protein NP_540445.1 1571007 R 224914 CDS NP_540446.1 17987812 1197240 complement(1572111..1574453) 1 NC_003317.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta 1574453 glyS 1197240 glyS Brucella melitensis bv. 1 str. 16M glycyl-tRNA synthetase subunit beta NP_540446.1 1572111 R 224914 CDS NP_540447.1 17987813 1197241 complement(1574450..1575400) 1 NC_003317.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha 1575400 glyQ 1197241 glyQ Brucella melitensis bv. 1 str. 16M glycyl-tRNA synthetase subunit alpha NP_540447.1 1574450 R 224914 CDS NP_540448.1 17987814 1197242 complement(1575528..1577309) 1 NC_003317.1 hypothetical protein 1577309 1197242 BMEI1531 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540448.1 1575528 R 224914 CDS NP_540449.1 17987815 1197243 complement(1577697..1578785) 1 NC_003317.1 farnesyl pyrophosphate synthetase 1578785 1197243 BMEI1532 Brucella melitensis bv. 1 str. 16M farnesyl pyrophosphate synthetase NP_540449.1 1577697 R 224914 CDS NP_540450.1 17987816 1197244 1578970..1579209 1 NC_003317.1 hypothetical protein 1579209 1197244 BMEI1533 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540450.1 1578970 D 224914 CDS NP_540451.1 17987817 1197245 1579206..1579988 1 NC_003317.1 methyltransferase 1579988 1197245 BMEI1534 Brucella melitensis bv. 1 str. 16M methyltransferase NP_540451.1 1579206 D 224914 CDS NP_540452.1 17987818 1197246 1580197..1582488 1 NC_003317.1 Na(+)/H(+) antiporter 1 / protease IV 1582488 1197246 BMEI1535 Brucella melitensis bv. 1 str. 16M Na(+)/H(+) antiporter 1 / protease IV NP_540452.1 1580197 D 224914 CDS NP_540453.1 17987819 1197247 1582919..1583140 1 NC_003317.1 hypothetical protein 1583140 1197247 BMEI1536 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540453.1 1582919 D 224914 CDS NP_540454.1 17987820 1197248 1583170..1584069 1 NC_003317.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 1584069 1197248 BMEI1537 Brucella melitensis bv. 1 str. 16M 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase NP_540454.1 1583170 D 224914 CDS NP_540455.1 17987821 1197249 1584123..1584356 1 NC_003317.1 hypothetical protein 1584356 1197249 BMEI1538 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540455.1 1584123 D 224914 CDS NP_540456.1 17987822 1197250 1584476..1584694 1 NC_003317.1 hypothetical protein 1584694 1197250 BMEI1539 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540456.1 1584476 D 224914 CDS NP_540457.1 17987823 1197251 complement(1584774..1585280) 1 NC_003317.1 glycosyltransferase 1585280 1197251 BMEI1540 Brucella melitensis bv. 1 str. 16M glycosyltransferase NP_540457.1 1584774 R 224914 CDS NP_540458.1 17987824 1197252 1585416..1586582 1 NC_003317.1 transporter 1586582 1197252 BMEI1541 Brucella melitensis bv. 1 str. 16M transporter NP_540458.1 1585416 D 224914 CDS NP_540459.1 17987825 1197253 1586759..1587421 1 NC_003317.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 1587421 rnhB 1197253 rnhB Brucella melitensis bv. 1 str. 16M ribonuclease HII NP_540459.1 1586759 D 224914 CDS NP_540460.2 161511127 1197254 complement(1587544..1588023) 1 NC_003317.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; ATP synthase F0F1 subunit B 1588023 1197254 BMEI1543 Brucella melitensis bv. 1 str. 16M ATP synthase F0F1 subunit B NP_540460.2 1587544 R 224914 CDS NP_540461.1 17987827 1197255 complement(1588034..1588576) 1 NC_003317.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B' is part of the membrane proton channel.; ATP synthase F0F1 subunit B' 1588576 1197255 BMEI1544 Brucella melitensis bv. 1 str. 16M ATP synthase F0F1 subunit B' NP_540461.1 1588034 R 224914 CDS NP_540462.1 17987828 1197256 complement(1588832..1589059) 1 NC_003317.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; ATP synthase F0F1 subunit C 1589059 1197256 BMEI1545 Brucella melitensis bv. 1 str. 16M ATP synthase F0F1 subunit C NP_540462.1 1588832 R 224914 CDS NP_540463.1 17987829 1197257 complement(1589127..1589960) 1 NC_003317.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; ATP synthase F0F1 subunit A 1589960 1197257 BMEI1546 Brucella melitensis bv. 1 str. 16M ATP synthase F0F1 subunit A NP_540463.1 1589127 R 224914 CDS NP_540464.1 17987830 1197258 complement(1589984..1590382) 1 NC_003317.1 ATP synthase 1590382 1197258 BMEI1547 Brucella melitensis bv. 1 str. 16M ATP synthase NP_540464.1 1589984 R 224914 CDS NP_540465.1 17987831 1197259 complement(1590653..1591831) 1 NC_003317.1 spore-cortex-lytic enzyme prepeptide 1591831 1197259 BMEI1548 Brucella melitensis bv. 1 str. 16M spore-cortex-lytic enzyme prepeptide NP_540465.1 1590653 R 224914 CDS NP_540466.1 17987832 1197260 complement(1592379..1593695) 1 NC_003317.1 molecular chaperone DnaK 1593695 1197260 BMEI1549 Brucella melitensis bv. 1 str. 16M molecular chaperone DnaK NP_540466.1 1592379 R 224914 CDS NP_540467.1 17987833 1197261 complement(1593854..1595305) 1 NC_003317.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 1595305 engA 1197261 engA Brucella melitensis bv. 1 str. 16M GTP-binding protein EngA NP_540467.1 1593854 R 224914 CDS NP_540468.1 17987834 1197262 complement(1595327..1595998) 1 NC_003317.1 hypothetical protein 1595998 1197262 BMEI1551 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540468.1 1595327 R 224914 CDS NP_540469.1 17987835 1197263 1596313..1597242 1 NC_003317.1 hypothetical protein 1597242 1197263 BMEI1552 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540469.1 1596313 D 224914 CDS NP_540470.1 17987836 1197264 complement(1597281..1598528) 1 NC_003317.1 in Escherichia coli SbmA is involved in uptake of microcin J25; functions along with FhuA, TonB, and ExbB/D in this capacity; in Sinorhizobium meliloti, BacA is essential and required for symbiosis; defects appear to affect the cell envelope; transporter 1598528 1197264 BMEI1553 Brucella melitensis bv. 1 str. 16M transporter NP_540470.1 1597281 R 224914 CDS NP_540471.1 17987837 1197265 complement(1598750..1599061) 1 NC_003317.1 major facilitator superfamily transporter 1599061 1197265 BMEI1554 Brucella melitensis bv. 1 str. 16M major facilitator superfamily transporter NP_540471.1 1598750 R 224914 CDS NP_540472.1 17987838 1197266 complement(1599043..1599861) 1 NC_003317.1 major facilitator superfamily transporter 1599861 1197266 BMEI1555 Brucella melitensis bv. 1 str. 16M major facilitator superfamily transporter NP_540472.1 1599043 R 224914 CDS NP_540473.1 17987839 1197267 complement(1600094..1601137) 1 NC_003317.1 hypothetical protein 1601137 1197267 BMEI1556 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540473.1 1600094 R 224914 CDS NP_540474.1 17987840 1197268 complement(1601475..1601825) 1 NC_003317.1 arsenate reductase 1601825 1197268 BMEI1557 Brucella melitensis bv. 1 str. 16M arsenate reductase NP_540474.1 1601475 R 224914 CDS NP_540475.1 17987841 1197269 complement(1602007..1603092) 1 NC_003317.1 ADA regulatory protein / O-6-methylguanine-DNA-alkyltransferase 1603092 1197269 BMEI1558 Brucella melitensis bv. 1 str. 16M ADA regulatory protein / O-6-methylguanine-DNA-alkyltransferase NP_540475.1 1602007 R 224914 CDS NP_540476.1 17987842 1197270 1603291..1603893 1 NC_003317.1 salicylaldehyde dehydrogenase 1603893 1197270 BMEI1559 Brucella melitensis bv. 1 str. 16M salicylaldehyde dehydrogenase NP_540476.1 1603291 D 224914 CDS NP_540477.1 17987843 1197271 1603734..1604735 1 NC_003317.1 salicylaldehyde dehydrogenase 1604735 1197271 BMEI1560 Brucella melitensis bv. 1 str. 16M salicylaldehyde dehydrogenase NP_540477.1 1603734 D 224914 CDS NP_540478.1 17987844 1197272 complement(1604784..1605377) 1 NC_003317.1 hypothetical protein 1605377 1197272 BMEI1561 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540478.1 1604784 R 224914 CDS NP_540479.1 17987845 1197273 complement(1605510..1605830) 1 NC_003317.1 hypothetical protein 1605830 1197273 BMEI1562 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540479.1 1605510 R 224914 CDS NP_540480.1 17987846 1197274 1605829..1606287 1 NC_003317.1 ferric uptake regulation protein 1606287 1197274 BMEI1563 Brucella melitensis bv. 1 str. 16M ferric uptake regulation protein NP_540480.1 1605829 D 224914 CDS NP_540481.1 17987847 1197275 1606505..1608130 1 NC_003317.1 CcoN; FixN; cbb3-type cytochrome c oxidase subunit I 1608130 1197275 BMEI1564 Brucella melitensis bv. 1 str. 16M cbb3-type cytochrome c oxidase subunit I NP_540481.1 1606505 D 224914 CDS NP_540482.1 17987848 1197276 1608145..1608876 1 NC_003317.1 CcoO; FixO; cbb3-type cytochrome c oxidase subunit II 1608876 1197276 BMEI1565 Brucella melitensis bv. 1 str. 16M cbb3-type cytochrome c oxidase subunit II NP_540482.1 1608145 D 224914 CDS NP_540483.1 17987849 1197277 1609006..1609905 1 NC_003317.1 cytochrome c oxidase, diheme subunit, membrane-bound 1609905 1197277 BMEI1566 Brucella melitensis bv. 1 str. 16M cytochrome c oxidase, diheme subunit, membrane-bound NP_540483.1 1609006 D 224914 CDS NP_540484.1 17987850 1197278 1610065..1611615 1 NC_003317.1 nitrogen fixation protein FIXG 1611615 1197278 BMEI1567 Brucella melitensis bv. 1 str. 16M nitrogen fixation protein FIXG NP_540484.1 1610065 D 224914 CDS NP_540485.1 17987851 1197279 1611615..1612112 1 NC_003317.1 nitrogen fixation protein FIXH 1612112 1197279 BMEI1568 Brucella melitensis bv. 1 str. 16M nitrogen fixation protein FIXH NP_540485.1 1611615 D 224914 CDS NP_540486.1 17987852 1197280 1612109..1614367 1 NC_003317.1 nitrogen fixation protein FIXI (E1-E2 type cation ATPase FIXI) 1614367 1197280 BMEI1569 Brucella melitensis bv. 1 str. 16M nitrogen fixation protein FIXI (E1-E2 type cation ATPase FIXI) NP_540486.1 1612109 D 224914 CDS NP_540487.1 17987853 1197281 complement(1614503..1615714) 1 NC_003317.1 hydroxypyruvate reductase 1615714 1197281 BMEI1570 Brucella melitensis bv. 1 str. 16M hydroxypyruvate reductase NP_540487.1 1614503 R 224914 CDS NP_540488.1 17987854 1197282 complement(1615734..1617038) 1 NC_003317.1 Catalyzes the deamination of guanine; guanine deaminase 1617038 1197282 BMEI1571 Brucella melitensis bv. 1 str. 16M guanine deaminase NP_540488.1 1615734 R 224914 CDS NP_540489.1 17987855 1197283 complement(1617035..1618288) 1 NC_003317.1 hypothetical protein 1618288 1197283 BMEI1572 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540489.1 1617035 R 224914 CDS NP_540490.1 17987856 1197284 1618388..1619371 1 NC_003317.1 LysR family transcriptional regulator 1619371 1197284 BMEI1573 Brucella melitensis bv. 1 str. 16M LysR family transcriptional regulator NP_540490.1 1618388 D 224914 CDS NP_540491.1 17987857 1197285 complement(1619452..1620324) 1 NC_003317.1 xanthine dehydrogenase subunit XdhC 1620324 1197285 BMEI1574 Brucella melitensis bv. 1 str. 16M xanthine dehydrogenase subunit XdhC NP_540491.1 1619452 R 224914 CDS NP_540492.1 17987858 1197286 complement(1620329..1622674) 1 NC_003317.1 xanthine dehydrogenase 1622674 1197286 BMEI1575 Brucella melitensis bv. 1 str. 16M xanthine dehydrogenase NP_540492.1 1620329 R 224914 CDS NP_540493.1 17987859 1197287 complement(1622687..1624246) 1 NC_003317.1 xanthine dehydrogenase 1624246 1197287 BMEI1576 Brucella melitensis bv. 1 str. 16M xanthine dehydrogenase NP_540493.1 1622687 R 224914 CDS NP_540494.1 17987860 1197288 1624713..1626140 1 NC_003317.1 chitooligosaccharide deacetylase 1626140 1197288 BMEI1577 Brucella melitensis bv. 1 str. 16M chitooligosaccharide deacetylase NP_540494.1 1624713 D 224914 CDS NP_540495.1 17987861 1197289 1626153..1626971 1 NC_003317.1 hypothetical protein 1626971 1197289 BMEI1578 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540495.1 1626153 D 224914 CDS NP_540496.1 17987862 1197290 complement(1627385..1628152) 1 NC_003317.1 periplasmic mannitol-binding protein 1628152 1197290 BMEI1579 Brucella melitensis bv. 1 str. 16M periplasmic mannitol-binding protein NP_540496.1 1627385 R 224914 CDS NP_540497.1 17987863 1197291 complement(1628226..1629827) 1 NC_003317.1 mannitol transporter, large subunit 1629827 1197291 BMEI1580 Brucella melitensis bv. 1 str. 16M mannitol transporter, large subunit NP_540497.1 1628226 R 224914 CDS NP_540498.1 17987864 1197292 complement(1629805..1630353) 1 NC_003317.1 tripartite transporter, small subunit 1630353 1197292 BMEI1581 Brucella melitensis bv. 1 str. 16M tripartite transporter, small subunit NP_540498.1 1629805 R 224914 CDS NP_540499.1 17987865 1197293 complement(1630641..1631282) 1 NC_003317.1 transcriptional regulatory protein DEGU 1631282 1197293 BMEI1582 Brucella melitensis bv. 1 str. 16M transcriptional regulatory protein DEGU NP_540499.1 1630641 R 224914 CDS NP_540500.1 17987866 1197294 complement(1631279..1632598) 1 NC_003317.1 sensor protein degS 1632598 1197294 BMEI1583 Brucella melitensis bv. 1 str. 16M sensor protein degS NP_540500.1 1631279 R 224914 CDS NP_540501.1 17987867 1197295 1632894..1633415 1 NC_003317.1 invasion protein B 1633415 1197295 BMEI1584 Brucella melitensis bv. 1 str. 16M invasion protein B NP_540501.1 1632894 D 224914 CDS NP_540502.1 17987868 1197296 complement(1633461..1634876) 1 NC_003317.1 Na+ driven multidrug efflux PUMP 1634876 1197296 BMEI1585 Brucella melitensis bv. 1 str. 16M Na+ driven multidrug efflux PUMP NP_540502.1 1633461 R 224914 CDS NP_540503.1 17987869 1197297 1635329..1636357 1 NC_003317.1 proline racemase 1636357 1197297 BMEI1586 Brucella melitensis bv. 1 str. 16M proline racemase NP_540503.1 1635329 D 224914 CDS NP_540504.1 17987870 1197298 1636382..1636597 1 NC_003317.1 hypothetical protein 1636597 1197298 BMEI1587 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540504.1 1636382 D 224914 CDS NP_540505.1 17987871 1197299 complement(1636613..1637854) 1 NC_003317.1 catalase 1637854 1197299 BMEI1588 Brucella melitensis bv. 1 str. 16M catalase NP_540505.1 1636613 R 224914 CDS NP_540506.1 17987872 1197300 complement(1638035..1639132) 1 NC_003317.1 carboxynorspermidine decarboxylase 1639132 1197300 BMEI1589 Brucella melitensis bv. 1 str. 16M carboxynorspermidine decarboxylase NP_540506.1 1638035 R 224914 CDS NP_540507.1 17987873 1197301 1639249..1639632 1 NC_003317.1 hypothetical protein 1639632 1197301 BMEI1590 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540507.1 1639249 D 224914 CDS NP_540508.1 17987874 1197302 1639936..1640712 1 NC_003317.1 ferredoxin-NADP reductase 1640712 1197302 BMEI1591 Brucella melitensis bv. 1 str. 16M ferredoxin-NADP reductase NP_540508.1 1639936 D 224914 CDS NP_540509.2 161511126 1197303 complement(1640909..1641736) 1 NC_003317.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase 1641736 panB 1197303 panB Brucella melitensis bv. 1 str. 16M 3-methyl-2-oxobutanoate hydroxymethyltransferase NP_540509.2 1640909 R 224914 CDS NP_540510.1 17987876 1197304 complement(1641738..1642619) 1 NC_003317.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase 1642619 panC 1197304 panC Brucella melitensis bv. 1 str. 16M pantoate--beta-alanine ligase NP_540510.1 1641738 R 224914 CDS NP_540511.1 17987877 1197305 complement(1642706..1643914) 1 NC_003317.1 hypothetical protein 1643914 1197305 BMEI1594 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540511.1 1642706 R 224914 CDS NP_540512.1 17987878 1197306 complement(1643985..1644371) 1 NC_003317.1 hypothetical protein 1644371 1197306 BMEI1595 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540512.1 1643985 R 224914 CDS NP_540513.1 17987879 1197307 complement(1644494..1645201) 1 NC_003317.1 LrgB protein 1645201 1197307 BMEI1596 Brucella melitensis bv. 1 str. 16M LrgB protein NP_540513.1 1644494 R 224914 CDS NP_540514.1 17987880 1197308 complement(1645188..1645541) 1 NC_003317.1 murein hydrolase exporter 1645541 1197308 BMEI1597 Brucella melitensis bv. 1 str. 16M murein hydrolase exporter NP_540514.1 1645188 R 224914 CDS NP_540515.1 17987881 1197309 1645729..1646619 1 NC_003317.1 LysR family transcriptional regulator 1646619 1197309 BMEI1598 Brucella melitensis bv. 1 str. 16M LysR family transcriptional regulator NP_540515.1 1645729 D 224914 CDS NP_540516.1 17987882 1197310 1646710..1646895 1 NC_003317.1 hypothetical protein 1646895 1197310 BMEI1599 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540516.1 1646710 D 224914 CDS NP_540517.1 17987883 1197311 1647044..1647343 1 NC_003317.1 urease operon 23 kDa accessory protein 1647343 1197311 BMEI1600 Brucella melitensis bv. 1 str. 16M urease operon 23 kDa accessory protein NP_540517.1 1647044 D 224914 CDS NP_540518.1 17987884 1197312 1647328..1647597 1 NC_003317.1 hypothetical protein 1647597 1197312 BMEI1601 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540518.1 1647328 D 224914 CDS NP_540519.1 17987885 1197313 1647790..1648509 1 NC_003317.1 glycosyltransferase 1648509 1197313 BMEI1602 Brucella melitensis bv. 1 str. 16M glycosyltransferase NP_540519.1 1647790 D 224914 CDS NP_540520.1 17987886 1197314 1648506..1649219 1 NC_003317.1 polysaccharide deacetylase 1649219 1197314 BMEI1603 Brucella melitensis bv. 1 str. 16M polysaccharide deacetylase NP_540520.1 1648506 D 224914 CDS NP_540521.1 17987887 1197315 1649365..1650642 1 NC_003317.1 catalyzes the formation of 5-aminolevulinate from succinyl-CoA and glycine; 5-aminolevulinate synthase 1650642 1197315 BMEI1604 Brucella melitensis bv. 1 str. 16M 5-aminolevulinate synthase NP_540521.1 1649365 D 224914 CDS NP_540522.1 17987888 1197316 complement(1650718..1651152) 1 NC_003317.1 homopentamer; channel that opens in response to pressure or hypoosmotic shock; large-conductance mechanosensitive channel 1651152 mscL 1197316 mscL Brucella melitensis bv. 1 str. 16M large-conductance mechanosensitive channel NP_540522.1 1650718 R 224914 CDS NP_540523.1 17987889 1197317 1651656..1655573 1 NC_003317.1 sensory transduction histidine kinase 1655573 1197317 BMEI1606 Brucella melitensis bv. 1 str. 16M sensory transduction histidine kinase NP_540523.1 1651656 D 224914 CDS NP_540524.1 17987890 1197318 complement(1655204..1655845) 1 NC_003317.1 glycerol metabolism activator 1655845 1197318 BMEI1607 Brucella melitensis bv. 1 str. 16M glycerol metabolism activator NP_540524.1 1655204 R 224914 CDS NP_540525.1 17987891 1197319 1656009..1657025 1 NC_003317.1 proline iminopeptidase 1657025 1197319 BMEI1608 Brucella melitensis bv. 1 str. 16M proline iminopeptidase NP_540525.1 1656009 D 224914 CDS NP_540526.1 17987892 1197320 complement(1657116..1657490) 1 NC_003317.1 hypothetical protein 1657490 1197320 BMEI1609 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540526.1 1657116 R 224914 CDS NP_540527.1 17987893 1197321 1657825..1658178 1 NC_003317.1 hypothetical protein 1658178 1197321 BMEI1610 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540527.1 1657825 D 224914 CDS NP_540528.1 17987894 1197322 1658175..1659269 1 NC_003317.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 1659269 1197322 BMEI1611 Brucella melitensis bv. 1 str. 16M dihydroorotate dehydrogenase 2 NP_540528.1 1658175 D 224914 CDS NP_540529.1 17987895 1197323 complement(1659271..1660626) 1 NC_003317.1 Na+ driven multidrug efflux PUMP 1660626 1197323 BMEI1612 Brucella melitensis bv. 1 str. 16M Na+ driven multidrug efflux PUMP NP_540529.1 1659271 R 224914 CDS NP_540530.1 17987896 1197324 complement(1660813..1661232) 1 NC_003317.1 hypothetical protein 1661232 1197324 BMEI1613 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540530.1 1660813 R 224914 CDS NP_540531.1 17987897 1197325 complement(1661332..1661598) 1 NC_003317.1 hypothetical protein 1661598 1197325 BMEI1614 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540531.1 1661332 R 224914 CDS NP_540532.1 17987898 1197326 complement(1661685..1662692) 1 NC_003317.1 AraC family transcriptional regulator 1662692 1197326 BMEI1615 Brucella melitensis bv. 1 str. 16M AraC family transcriptional regulator NP_540532.1 1661685 R 224914 CDS NP_540533.1 17987899 1197327 complement(1662792..1663883) 1 NC_003317.1 Catalyzes the deamination of dCTP to form dUTP; 2'-deoxycytidine 5'-triphosphate deaminase 1663883 1197327 BMEI1616 Brucella melitensis bv. 1 str. 16M 2'-deoxycytidine 5'-triphosphate deaminase NP_540533.1 1662792 R 224914 CDS NP_540534.1 17987900 1197328 1664301..1665506 1 NC_003317.1 catalyzes the conversion of O-succinylhomoserine and sulfide to homocysteine; second step in methionine biosynthesis; O-succinylhomoserine sulfhydrylase 1665506 1197328 BMEI1617 Brucella melitensis bv. 1 str. 16M O-succinylhomoserine sulfhydrylase NP_540534.1 1664301 D 224914 CDS NP_540535.1 17987901 1197329 1665842..1666267 1 NC_003317.1 protein associated with Co2+ and Mg2+ efflux; ApaG protein 1666267 apaG 1197329 apaG Brucella melitensis bv. 1 str. 16M ApaG protein NP_540535.1 1665842 D 224914 CDS NP_540536.1 17987902 1197330 complement(1666308..1667330) 1 NC_003317.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; heat shock protein 33 1667330 hslO 1197330 hslO Brucella melitensis bv. 1 str. 16M heat shock protein 33 NP_540536.1 1666308 R 224914 CDS NP_540537.2 161511125 1197331 complement(1667332..1668270) 1 NC_003317.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; ornithine carbamoyltransferase 1668270 1197331 BMEI1620 Brucella melitensis bv. 1 str. 16M ornithine carbamoyltransferase NP_540537.2 1667332 R 224914 CDS NP_540538.1 17987904 1197332 complement(1668275..1669486) 1 NC_003317.1 DapATase; functions in arginine biosynthetic pathway; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine; acetylornithine transaminase protein 1669486 argD 1197332 argD Brucella melitensis bv. 1 str. 16M acetylornithine transaminase protein NP_540538.1 1668275 R 224914 CDS NP_540539.1 17987905 1197333 1669562..1669918 1 NC_003317.1 hypothetical protein 1669918 1197333 BMEI1622 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540539.1 1669562 D 224914 CDS NP_540540.1 17987906 1197334 1670075..1670632 1 NC_003317.1 hypothetical protein 1670632 1197334 BMEI1623 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540540.1 1670075 D 224914 CDS NP_540541.1 17987907 1197335 complement(1670762..1672000) 1 NC_003317.1 phosphate regulon sensor protein PHOR 1672000 1197335 BMEI1624 Brucella melitensis bv. 1 str. 16M phosphate regulon sensor protein PHOR NP_540541.1 1670762 R 224914 CDS NP_540542.1 17987908 1197336 1672215..1673174 1 NC_003317.1 UDP-galactose-lipid carrier transferase 1673174 1197336 BMEI1625 Brucella melitensis bv. 1 str. 16M UDP-galactose-lipid carrier transferase NP_540542.1 1672215 D 224914 CDS NP_540543.1 17987909 1197337 complement(1673102..1674706) 1 NC_003317.1 N-acetylglucosaminyltransferase 1674706 1197337 BMEI1626 Brucella melitensis bv. 1 str. 16M N-acetylglucosaminyltransferase NP_540543.1 1673102 R 224914 CDS NP_540544.1 17987910 1197338 1675296..1676105 1 NC_003317.1 arginine-binding periplasmic protein 1676105 1197338 BMEI1627 Brucella melitensis bv. 1 str. 16M arginine-binding periplasmic protein NP_540544.1 1675296 D 224914 CDS NP_540545.1 17987911 1197339 complement(1676102..1676413) 1 NC_003317.1 hypothetical protein 1676413 1197339 BMEI1628 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540545.1 1676102 R 224914 CDS NP_540546.1 17987912 1197340 complement(1676813..1679968) 1 NC_003317.1 multidrug resistance protein MEXB 1679968 1197340 BMEI1629 Brucella melitensis bv. 1 str. 16M multidrug resistance protein MEXB NP_540546.1 1676813 R 224914 CDS NP_540547.1 17987913 1197341 complement(1679965..1681152) 1 NC_003317.1 acriflavin resistance protein A 1681152 1197341 BMEI1630 Brucella melitensis bv. 1 str. 16M acriflavin resistance protein A NP_540547.1 1679965 R 224914 CDS NP_540548.1 17987914 1197342 1681331..1681960 1 NC_003317.1 TetR family transcriptional regulator 1681960 1197342 BMEI1631 Brucella melitensis bv. 1 str. 16M TetR family transcriptional regulator NP_540548.1 1681331 D 224914 CDS NP_540549.1 17987915 1197343 1682137..1684056 1 NC_003317.1 activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 1684056 1197343 BMEI1632 Brucella melitensis bv. 1 str. 16M long-chain-fatty-acid--CoA ligase NP_540549.1 1682137 D 224914 CDS NP_540550.1 17987916 1197344 1684170..1684952 1 NC_003317.1 alpha/beta hydrolase 1684952 1197344 BMEI1633 Brucella melitensis bv. 1 str. 16M alpha/beta hydrolase NP_540550.1 1684170 D 224914 CDS NP_540551.1 17987917 1197345 complement(1684925..1685671) 1 NC_003317.1 phosphoglycolate phosphatase 1685671 1197345 BMEI1634 Brucella melitensis bv. 1 str. 16M phosphoglycolate phosphatase NP_540551.1 1684925 R 224914 CDS NP_540552.1 17987918 1197346 complement(1685671..1686732) 1 NC_003317.1 arginine/ornithine transporter 1686732 1197346 BMEI1635 Brucella melitensis bv. 1 str. 16M arginine/ornithine transporter NP_540552.1 1685671 R 224914 CDS NP_540553.1 17987919 1197347 complement(1686968..1688617) 1 NC_003317.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 1688617 pgi 1197347 pgi Brucella melitensis bv. 1 str. 16M glucose-6-phosphate isomerase NP_540553.1 1686968 R 224914 CDS NP_540554.1 17987920 1197348 1688768..1689220 1 NC_003317.1 CoxG protein 1689220 1197348 BMEI1637 Brucella melitensis bv. 1 str. 16M CoxG protein NP_540554.1 1688768 D 224914 CDS NP_540555.1 17987921 1197349 1689408..1690904 1 NC_003317.1 function undetermined; similar to glutamate synthase beta subunit and related oxidoreductases which transfer electrons from NADPH to an acceptor protein or protein domain; oxidoreductase 1690904 1197349 BMEI1638 Brucella melitensis bv. 1 str. 16M oxidoreductase NP_540555.1 1689408 D 224914 CDS NP_540556.1 17987922 1197350 1690908..1692218 1 NC_003317.1 catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines; dihydropyrimidine dehydrogenase 1692218 1197350 BMEI1639 Brucella melitensis bv. 1 str. 16M dihydropyrimidine dehydrogenase NP_540556.1 1690908 D 224914 CDS NP_540557.1 17987923 1197351 complement(1692263..1692652) 1 NC_003317.1 phosphohydrolase 1692652 1197351 BMEI1640 Brucella melitensis bv. 1 str. 16M phosphohydrolase NP_540557.1 1692263 R 224914 CDS NP_540558.1 17987924 1197352 complement(1692649..1693101) 1 NC_003317.1 TetR family transcriptional regulator 1693101 1197352 BMEI1641 Brucella melitensis bv. 1 str. 16M TetR family transcriptional regulator NP_540558.1 1692649 R 224914 CDS NP_540559.1 17987925 1197353 complement(1693132..1693332) 1 NC_003317.1 TetR family transcriptional regulator 1693332 1197353 BMEI1642 Brucella melitensis bv. 1 str. 16M TetR family transcriptional regulator NP_540559.1 1693132 R 224914 CDS NP_540560.1 17987926 1197354 1693551..1694798 1 NC_003317.1 allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide; allantoate amidohydrolase 1694798 1197354 BMEI1643 Brucella melitensis bv. 1 str. 16M allantoate amidohydrolase NP_540560.1 1693551 D 224914 CDS NP_540561.1 17987927 1197355 1694850..1696319 1 NC_003317.1 catalyzes the hydrolytic cleavage of hydantoin with aromatic side chains at the 5'position; phenylhydantoinase 1696319 1197355 BMEI1644 Brucella melitensis bv. 1 str. 16M phenylhydantoinase NP_540561.1 1694850 D 224914 CDS NP_540562.1 17987928 1197356 complement(1696442..1699573) 1 NC_003317.1 acriflavin resistance protein B 1699573 1197356 BMEI1645 Brucella melitensis bv. 1 str. 16M acriflavin resistance protein B NP_540562.1 1696442 R 224914 CDS NP_540563.1 17987929 1197357 complement(1699588..1700739) 1 NC_003317.1 acriflavin resistance protein E 1700739 1197357 BMEI1646 Brucella melitensis bv. 1 str. 16M acriflavin resistance protein E NP_540563.1 1699588 R 224914 CDS NP_540564.1 17987930 1197358 1700699..1701007 1 NC_003317.1 hypothetical protein 1701007 1197358 BMEI1647 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540564.1 1700699 D 224914 CDS NP_540565.1 17987931 1197359 1701267..1702649 1 NC_003317.1 sensory transduction protein kinase 1702649 1197359 BMEI1648 Brucella melitensis bv. 1 str. 16M sensory transduction protein kinase NP_540565.1 1701267 D 224914 CDS NP_540566.1 17987932 1197360 complement(1703006..1703632) 1 NC_003317.1 urease accessory protein UREG 1703632 1197360 BMEI1649 Brucella melitensis bv. 1 str. 16M urease accessory protein UREG NP_540566.1 1703006 R 224914 CDS NP_540567.1 17987933 1197361 complement(1703629..1704315) 1 NC_003317.1 urease accessory protein UREF 1704315 1197361 BMEI1650 Brucella melitensis bv. 1 str. 16M urease accessory protein UREF NP_540567.1 1703629 R 224914 CDS NP_540568.1 17987934 1197362 complement(1704287..1704802) 1 NC_003317.1 involved in the assembly of the urease metallocenter; possible nickel donor; urease accessory protein UreE 1704802 ureE 1197362 ureE Brucella melitensis bv. 1 str. 16M urease accessory protein UreE NP_540568.1 1704287 R 224914 CDS NP_540569.1 17987935 1197363 complement(1704818..1706530) 1 NC_003317.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits; urease subunit alpha 1706530 ureC 1197363 ureC Brucella melitensis bv. 1 str. 16M urease subunit alpha NP_540569.1 1704818 R 224914 CDS NP_540570.1 17987936 1197364 complement(1706549..1706854) 1 NC_003317.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori and Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta); in Brucella suis the urease encoded by this operon (one of two urease-encoding operons found in its genome) is involved with urease activity, optimum growth, resistance to low-pH killing in-vitro and persistence in-vivo, while the other operon does not seem to be active; urease subunit beta 1706854 ureB 1197364 ureB Brucella melitensis bv. 1 str. 16M urease subunit beta NP_540570.1 1706549 R 224914 CDS NP_540571.1 17987937 1197365 complement(1707021..1707272) 1 NC_003317.1 urease subunit gamma 1707272 1197365 BMEI1654 Brucella melitensis bv. 1 str. 16M urease subunit gamma NP_540571.1 1707021 R 224914 CDS NP_540572.1 17987938 1197366 complement(1707477..1708280) 1 NC_003317.1 urease accessory protein URED 1708280 1197366 BMEI1655 Brucella melitensis bv. 1 str. 16M urease accessory protein URED NP_540572.1 1707477 R 224914 CDS NP_540573.1 17987939 1197367 complement(1708913..1709302) 1 NC_003317.1 hypothetical protein 1709302 1197367 BMEI1656 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540573.1 1708913 R 224914 CDS NP_540574.1 17987940 1197368 1709386..1709646 1 NC_003317.1 hypothetical protein 1709646 1197368 BMEI1657 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540574.1 1709386 D 224914 CDS NP_540575.1 17987941 1197369 1709760..1710044 1 NC_003317.1 hypothetical protein 1710044 1197369 BMEI1658 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540575.1 1709760 D 224914 CDS NP_540576.1 17987942 1197370 1710657..1710902 1 NC_003317.1 hypothetical protein 1710902 1197370 BMEI1659 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540576.1 1710657 D 224914 CDS NP_540577.1 17987943 1197371 complement(1711347..1712690) 1 NC_003317.1 hypothetical protein 1712690 1197371 BMEI1660 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540577.1 1711347 R 224914 CDS NP_540578.1 17987944 1197372 complement(1713088..1713834) 1 NC_003317.1 recombinase 1713834 1197372 BMEI1661 Brucella melitensis bv. 1 str. 16M recombinase NP_540578.1 1713088 R 224914 CDS NP_540579.1 17987945 1197373 1713892..1714251 1 NC_003317.1 hypothetical protein 1714251 1197373 BMEI1662 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540579.1 1713892 D 224914 CDS NP_540580.1 17987946 1197374 complement(1714483..1714905) 1 NC_003317.1 antirepressor protein ANT 1714905 1197374 BMEI1663 Brucella melitensis bv. 1 str. 16M antirepressor protein ANT NP_540580.1 1714483 R 224914 CDS NP_540581.1 17987947 1197375 complement(1715000..1716766) 1 NC_003317.1 hypothetical protein 1716766 1197375 BMEI1664 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540581.1 1715000 R 224914 CDS NP_540582.1 17987948 1197376 complement(1716955..1717305) 1 NC_003317.1 hypothetical protein 1717305 1197376 BMEI1665 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540582.1 1716955 R 224914 CDS NP_540583.1 17987949 1197377 1717420..1718760 1 NC_003317.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1718760 1197377 BMEI1666 Brucella melitensis bv. 1 str. 16M UDP-N-acetylglucosamine 1-carboxyvinyltransferase NP_540583.1 1717420 D 224914 CDS NP_540584.1 17987950 1197378 1719040..1719471 1 NC_003317.1 hypothetical protein 1719471 1197378 BMEI1667 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540584.1 1719040 D 224914 CDS NP_540585.1 17987951 1197379 1719546..1720838 1 NC_003317.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase 1720838 hisD 1197379 hisD Brucella melitensis bv. 1 str. 16M histidinol dehydrogenase NP_540585.1 1719546 D 224914 CDS NP_540586.1 17987952 1197380 1720845..1721327 1 NC_003317.1 hypothetical protein 1721327 1197380 BMEI1669 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540586.1 1720845 D 224914 CDS NP_540587.1 17987953 1197381 1721334..1721807 1 NC_003317.1 arsenate reductase 1721807 1197381 BMEI1670 Brucella melitensis bv. 1 str. 16M arsenate reductase NP_540587.1 1721334 D 224914 CDS NP_540588.1 17987954 1197382 1721832..1722137 1 NC_003317.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 1722137 infA 1197382 infA Brucella melitensis bv. 1 str. 16M translation initiation factor IF-1 NP_540588.1 1721832 D 224914 CDS NP_540589.1 17987955 1197383 1722165..1722797 1 NC_003317.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 1722797 maf 1197383 maf Brucella melitensis bv. 1 str. 16M Maf-like protein NP_540589.1 1722165 D 224914 CDS NP_540590.1 17987956 1197384 1722807..1723022 1 NC_003317.1 zinc-binding protein 1723022 1197384 BMEI1673 Brucella melitensis bv. 1 str. 16M zinc-binding protein NP_540590.1 1722807 D 224914 CDS NP_540591.1 17987957 1197385 1724077..1724829 1 NC_003317.1 hypothetical protein 1724829 1197385 BMEI1674 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540591.1 1724077 D 224914 CDS NP_540592.1 17987958 1197386 complement(1724950..1725186) 1 NC_003317.1 hypothetical protein 1725186 1197386 BMEI1675 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540592.1 1724950 R 224914 CDS NP_540593.1 17987959 1197387 complement(1725529..1726137) 1 NC_003317.1 hypothetical protein 1726137 1197387 BMEI1676 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540593.1 1725529 R 224914 CDS NP_540594.1 17987960 1197388 complement(1726408..1726872) 1 NC_003317.1 hypothetical protein 1726872 1197388 BMEI1677 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540594.1 1726408 R 224914 CDS NP_540595.1 17987961 1197389 complement(1726944..1727234) 1 NC_003317.1 hypothetical protein 1727234 1197389 BMEI1678 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540595.1 1726944 R 224914 CDS NP_540596.1 17987962 1197390 complement(1727300..1727545) 1 NC_003317.1 hypothetical protein 1727545 1197390 BMEI1679 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540596.1 1727300 R 224914 CDS NP_540597.1 17987963 1197391 1727623..1727868 1 NC_003317.1 hypothetical protein 1727868 1197391 BMEI1680 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540597.1 1727623 D 224914 CDS NP_540598.1 17987964 1197392 1727932..1728408 1 NC_003317.1 hypothetical protein 1728408 1197392 BMEI1681 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540598.1 1727932 D 224914 CDS NP_540599.1 17987965 1197393 1728405..1728890 1 NC_003317.1 hypothetical protein 1728890 1197393 BMEI1682 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540599.1 1728405 D 224914 CDS NP_540600.1 17987966 1197394 complement(1729275..1729823) 1 NC_003317.1 zinc-dependent metallopeptidase 1729823 1197394 BMEI1683 Brucella melitensis bv. 1 str. 16M zinc-dependent metallopeptidase NP_540600.1 1729275 R 224914 CDS NP_540601.1 17987967 1197395 1729845..1730009 1 NC_003317.1 hypothetical protein 1730009 1197395 BMEI1684 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540601.1 1729845 D 224914 CDS NP_540602.1 17987968 1197396 1730353..1730586 1 NC_003317.1 hypothetical protein 1730586 1197396 BMEI1685 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540602.1 1730353 D 224914 CDS NP_540603.1 17987969 1197397 complement(1730670..1731023) 1 NC_003317.1 hypothetical protein 1731023 1197397 BMEI1686 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540603.1 1730670 R 224914 CDS NP_540604.1 17987970 1197398 complement(1731087..1731293) 1 NC_003317.1 hypothetical protein 1731293 1197398 BMEI1687 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540604.1 1731087 R 224914 CDS NP_540605.1 17987971 1197399 complement(1731290..1731880) 1 NC_003317.1 hypothetical protein 1731880 1197399 BMEI1688 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540605.1 1731290 R 224914 CDS NP_540606.1 17987972 1197400 complement(1731871..1732350) 1 NC_003317.1 hypothetical protein 1732350 1197400 BMEI1689 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540606.1 1731871 R 224914 CDS NP_540607.1 17987973 1197401 complement(1732392..1732697) 1 NC_003317.1 hypothetical protein 1732697 1197401 BMEI1690 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540607.1 1732392 R 224914 CDS NP_540608.1 17987974 1197402 complement(1732898..1734790) 1 NC_003317.1 hypothetical protein 1734790 1197402 BMEI1691 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540608.1 1732898 R 224914 CDS NP_540609.1 17987975 1197403 complement(1734940..1736856) 1 NC_003317.1 flagellar protein FLGJ 1736856 1197403 BMEI1692 Brucella melitensis bv. 1 str. 16M flagellar protein FLGJ NP_540609.1 1734940 R 224914 CDS NP_540610.1 17987976 1197404 complement(1737057..1737266) 1 NC_003317.1 hypothetical protein 1737266 1197404 BMEI1693 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540610.1 1737057 R 224914 CDS NP_540611.1 17987977 1197405 complement(1737368..1738384) 1 NC_003317.1 hypothetical protein 1738384 1197405 BMEI1694 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540611.1 1737368 R 224914 CDS NP_540612.1 17987978 1197406 complement(1738538..1739155) 1 NC_003317.1 hypothetical protein 1739155 1197406 BMEI1695 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540612.1 1738538 R 224914 CDS NP_540613.1 17987979 1197407 complement(1739125..1740654) 1 NC_003317.1 hypothetical protein 1740654 1197407 BMEI1696 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540613.1 1739125 R 224914 CDS NP_540614.1 17987980 1197408 complement(1740651..1741532) 1 NC_003317.1 virulence-associated protein E 1741532 1197408 BMEI1697 Brucella melitensis bv. 1 str. 16M virulence-associated protein E NP_540614.1 1740651 R 224914 CDS NP_540615.1 17987981 1197409 complement(1741529..1741843) 1 NC_003317.1 hypothetical protein 1741843 1197409 BMEI1698 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540615.1 1741529 R 224914 CDS NP_540616.1 17987982 1197410 complement(1741840..1742049) 1 NC_003317.1 hypothetical protein 1742049 1197410 BMEI1699 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540616.1 1741840 R 224914 CDS NP_540617.1 17987983 1197411 complement(1742050..1742268) 1 NC_003317.1 hypothetical protein 1742268 1197411 BMEI1700 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540617.1 1742050 R 224914 CDS NP_540618.1 17987984 1197412 1742369..1742641 1 NC_003317.1 hypothetical protein 1742641 1197412 BMEI1701 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540618.1 1742369 D 224914 CDS NP_540619.1 17987985 1197413 complement(1742779..1743975) 1 NC_003317.1 transposase 1743975 1197413 BMEI1702 Brucella melitensis bv. 1 str. 16M transposase NP_540619.1 1742779 R 224914 CDS NP_540620.1 17987986 1197414 1744147..1744464 1 NC_003317.1 hypothetical protein 1744464 1197414 BMEI1703 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540620.1 1744147 D 224914 CDS NP_540621.1 17987987 1197415 complement(1744547..1744948) 1 NC_003317.1 hypothetical protein 1744948 1197415 BMEI1704 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540621.1 1744547 R 224914 CDS NP_540622.1 17987988 1197416 1744919..1745131 1 NC_003317.1 hypothetical protein 1745131 1197416 BMEI1705 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540622.1 1744919 D 224914 CDS NP_540623.1 17987989 1197417 1745166..1745717 1 NC_003317.1 hypothetical protein 1745717 1197417 BMEI1706 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540623.1 1745166 D 224914 CDS NP_540624.1 17987990 1197418 complement(1746116..1747393) 1 NC_003317.1 mandelate racemase 1747393 1197418 BMEI1707 Brucella melitensis bv. 1 str. 16M mandelate racemase NP_540624.1 1746116 R 224914 CDS NP_540625.1 17987991 1197419 complement(1747407..1748312) 1 NC_003317.1 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase 1748312 1197419 BMEI1708 Brucella melitensis bv. 1 str. 16M 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase NP_540625.1 1747407 R 224914 CDS NP_540626.1 17987992 1197420 complement(1748293..1749027) 1 NC_003317.1 oxidoreductase UcpA 1749027 1197420 BMEI1709 Brucella melitensis bv. 1 str. 16M oxidoreductase UcpA NP_540626.1 1748293 R 224914 CDS NP_540627.1 17987993 1197421 complement(1749132..1750211) 1 NC_003317.1 oxidoreductase 1750211 1197421 BMEI1710 Brucella melitensis bv. 1 str. 16M oxidoreductase NP_540627.1 1749132 R 224914 CDS NP_540628.1 17987994 1197422 complement(1750204..1750548) 1 NC_003317.1 hypothetical protein 1750548 1197422 BMEI1711 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540628.1 1750204 R 224914 CDS NP_540629.1 17987995 1197423 complement(1750545..1751663) 1 NC_003317.1 mandelate racemase 1751663 1197423 BMEI1712 Brucella melitensis bv. 1 str. 16M mandelate racemase NP_540629.1 1750545 R 224914 CDS NP_540630.1 17987996 1197424 complement(1751666..1752757) 1 NC_003317.1 maltose ABC transporter ATP-binding protein 1752757 1197424 BMEI1713 Brucella melitensis bv. 1 str. 16M maltose ABC transporter ATP-binding protein NP_540630.1 1751666 R 224914 CDS NP_540631.1 17987997 1197425 complement(1752765..1753649) 1 NC_003317.1 maltose ABC transporter permease 1753649 1197425 BMEI1714 Brucella melitensis bv. 1 str. 16M maltose ABC transporter permease NP_540631.1 1752765 R 224914 CDS NP_540632.1 17987998 1197426 complement(1753643..1754566) 1 NC_003317.1 maltose ABC transporter permease 1754566 1197426 BMEI1715 Brucella melitensis bv. 1 str. 16M maltose ABC transporter permease NP_540632.1 1753643 R 224914 CDS NP_540633.1 17987999 1197427 complement(1754627..1755898) 1 NC_003317.1 trehalose/maltose binding protein 1755898 1197427 BMEI1716 Brucella melitensis bv. 1 str. 16M trehalose/maltose binding protein NP_540633.1 1754627 R 224914 CDS NP_540634.1 17988000 1197428 1756104..1756898 1 NC_003317.1 IclR family transcriptional regulator 1756898 1197428 BMEI1717 Brucella melitensis bv. 1 str. 16M IclR family transcriptional regulator NP_540634.1 1756104 D 224914 CDS NP_540635.1 17988001 1197429 1756956..1757804 1 NC_003317.1 purine/pyrimidine phosphoribosyl transferase 1757804 1197429 BMEI1718 Brucella melitensis bv. 1 str. 16M purine/pyrimidine phosphoribosyl transferase NP_540635.1 1756956 D 224914 CDS NP_540636.1 17988002 1197430 complement(1757857..1758411) 1 NC_003317.1 sarcosine oxidase subunit gamma 1758411 1197430 BMEI1719 Brucella melitensis bv. 1 str. 16M sarcosine oxidase subunit gamma NP_540636.1 1757857 R 224914 CDS NP_540637.1 17988003 1197431 complement(1758422..1761424) 1 NC_003317.1 sarcosine oxidase subunit alpha 1761424 1197431 BMEI1720 Brucella melitensis bv. 1 str. 16M sarcosine oxidase subunit alpha NP_540637.1 1758422 R 224914 CDS NP_540638.1 17988004 1197432 complement(1761421..1761726) 1 NC_003317.1 sarcosine oxidase subunit delta 1761726 1197432 BMEI1721 Brucella melitensis bv. 1 str. 16M sarcosine oxidase subunit delta NP_540638.1 1761421 R 224914 CDS NP_540639.1 17988005 1197433 complement(1761745..1763004) 1 NC_003317.1 sarcosine oxidase subunit beta 1763004 1197433 BMEI1722 Brucella melitensis bv. 1 str. 16M sarcosine oxidase subunit beta NP_540639.1 1761745 R 224914 CDS NP_540640.1 17988006 1197434 1763325..1764590 1 NC_003317.1 NADP-specific glutamate dehydrogenase 1764590 1197434 BMEI1723 Brucella melitensis bv. 1 str. 16M NADP-specific glutamate dehydrogenase NP_540640.1 1763325 D 224914 CDS NP_540641.1 17988007 1197435 1764894..1765544 1 NC_003317.1 hypothetical protein 1765544 1197435 BMEI1724 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540641.1 1764894 D 224914 CDS NP_540642.1 17988008 1197436 1765730..1766644 1 NC_003317.1 glycine betaine-binding protein 1766644 1197436 BMEI1725 Brucella melitensis bv. 1 str. 16M glycine betaine-binding protein NP_540642.1 1765730 D 224914 CDS NP_540643.1 17988009 1197437 1766717..1767877 1 NC_003317.1 glycine betaine/L-proline transport system permease protein proW 1767877 1197437 BMEI1726 Brucella melitensis bv. 1 str. 16M glycine betaine/L-proline transport system permease protein proW NP_540643.1 1766717 D 224914 CDS NP_540644.1 17988010 1197438 1767448..1768812 1 NC_003317.1 glycine betaine/L-proline transport ATP-binding protein proV 1768812 1197438 BMEI1727 Brucella melitensis bv. 1 str. 16M glycine betaine/L-proline transport ATP-binding protein proV NP_540644.1 1767448 D 224914 CDS NP_540645.1 17988011 1197439 1768854..1769555 1 NC_003317.1 glycine betaine/L-proline transport system permease protein proW 1769555 1197439 BMEI1728 Brucella melitensis bv. 1 str. 16M glycine betaine/L-proline transport system permease protein proW NP_540645.1 1768854 D 224914 CDS NP_540646.1 17988012 1197440 1769706..1769936 1 NC_003317.1 mercuric resistance operon regulatory protein 1769936 1197440 BMEI1729 Brucella melitensis bv. 1 str. 16M mercuric resistance operon regulatory protein NP_540646.1 1769706 D 224914 CDS NP_540647.1 17988013 1197441 complement(1769916..1772396) 1 NC_003317.1 copper-transporting ATPase 1772396 1197441 BMEI1730 Brucella melitensis bv. 1 str. 16M copper-transporting ATPase NP_540647.1 1769916 R 224914 CDS NP_540648.1 17988014 1197442 complement(1772495..1774624) 1 NC_003317.1 diguanylate cyclase/phosphodiesterase 1774624 1197442 BMEI1731 Brucella melitensis bv. 1 str. 16M diguanylate cyclase/phosphodiesterase NP_540648.1 1772495 R 224914 CDS NP_540649.1 17988015 1197443 1774996..1775910 1 NC_003317.1 phosphomethylpyrimidine kinase / hydroxymethylpyrimidine kinase 1775910 1197443 BMEI1732 Brucella melitensis bv. 1 str. 16M phosphomethylpyrimidine kinase / hydroxymethylpyrimidine kinase NP_540649.1 1774996 D 224914 CDS NP_540650.1 17988016 1197444 1775880..1776914 1 NC_003317.1 thiamine biosynthesis oxidoreductase THIO 1776914 1197444 BMEI1733 Brucella melitensis bv. 1 str. 16M thiamine biosynthesis oxidoreductase THIO NP_540650.1 1775880 D 224914 CDS NP_540651.1 17988017 1197445 1776911..1777108 1 NC_003317.1 hypothetical protein 1777108 1197445 BMEI1734 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540651.1 1776911 D 224914 CDS NP_540652.2 161511124 1197446 1777110..1777880 1 NC_003317.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate; thiazole synthase 1777880 thiG 1197446 thiG Brucella melitensis bv. 1 str. 16M thiazole synthase NP_540652.2 1777110 D 224914 CDS NP_540653.1 17988019 1197447 1777877..1778488 1 NC_003317.1 Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate; thiamine-phosphate pyrophosphorylase 1778488 thiE 1197447 thiE Brucella melitensis bv. 1 str. 16M thiamine-phosphate pyrophosphorylase NP_540653.1 1777877 D 224914 CDS NP_540654.1 17988020 1197448 1778455..1779480 1 NC_003317.1 ABC transporter substrate-binding protein 1779480 1197448 BMEI1737 Brucella melitensis bv. 1 str. 16M ABC transporter substrate-binding protein NP_540654.1 1778455 D 224914 CDS NP_540655.1 17988021 1197449 1779477..1780175 1 NC_003317.1 transcriptional activator TENA 1780175 1197449 BMEI1738 Brucella melitensis bv. 1 str. 16M transcriptional activator TENA NP_540655.1 1779477 D 224914 CDS NP_540656.1 17988022 1197450 1780172..1780807 1 NC_003317.1 ABC transporter membrane protein 1780807 1197450 BMEI1739 Brucella melitensis bv. 1 str. 16M ABC transporter membrane protein NP_540656.1 1780172 D 224914 CDS NP_540657.1 17988023 1197451 complement(1780992..1782425) 1 NC_003317.1 aldehyde dehydrogenase 1782425 1197451 BMEI1740 Brucella melitensis bv. 1 str. 16M aldehyde dehydrogenase NP_540657.1 1780992 R 224914 CDS NP_540658.1 17988024 1197452 complement(1782728..1782928) 1 NC_003317.1 hypothetical protein 1782928 1197452 BMEI1741 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540658.1 1782728 R 224914 CDS NP_540659.1 17988025 1197453 1783019..1784227 1 NC_003317.1 ABC transporter ATP-binding protein 1784227 1197453 BMEI1742 Brucella melitensis bv. 1 str. 16M ABC transporter ATP-binding protein NP_540659.1 1783019 D 224914 CDS NP_540660.1 17988026 1197454 1783882..1784844 1 NC_003317.1 ABC transporter ATP-binding protein 1784844 1197454 BMEI1743 Brucella melitensis bv. 1 str. 16M ABC transporter ATP-binding protein NP_540660.1 1783882 D 224914 CDS NP_540661.1 17988027 1197455 complement(1784936..1785958) 1 NC_003317.1 glucose-resistance amylase regulator 1785958 1197455 BMEI1744 Brucella melitensis bv. 1 str. 16M glucose-resistance amylase regulator NP_540661.1 1784936 R 224914 CDS NP_540662.1 17988028 1197456 complement(1786020..1786391) 1 NC_003317.1 hypothetical protein 1786391 1197456 BMEI1745 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540662.1 1786020 R 224914 CDS NP_540663.1 17988029 1197457 complement(1786443..1787564) 1 NC_003317.1 alcohol dehydrogenase 1787564 1197457 BMEI1746 Brucella melitensis bv. 1 str. 16M alcohol dehydrogenase NP_540663.1 1786443 R 224914 CDS NP_540664.1 17988030 1197458 complement(1787949..1789466) 1 NC_003317.1 aldehyde dehydrogenase 1789466 1197458 BMEI1747 Brucella melitensis bv. 1 str. 16M aldehyde dehydrogenase NP_540664.1 1787949 R 224914 CDS NP_540665.1 17988031 1197459 complement(1789615..1790694) 1 NC_003317.1 transcriptional regulator 1790694 1197459 BMEI1748 Brucella melitensis bv. 1 str. 16M transcriptional regulator NP_540665.1 1789615 R 224914 CDS NP_540666.1 17988032 1197460 complement(1790802..1792337) 1 NC_003317.1 in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane; glycerol-3-phosphate dehydrogenase 1792337 glpD 1197460 glpD Brucella melitensis bv. 1 str. 16M glycerol-3-phosphate dehydrogenase NP_540666.1 1790802 R 224914 CDS NP_540667.1 17988033 1197461 complement(1792386..1793246) 1 NC_003317.1 glycerol-3-phosphate regulon repressor 1793246 1197461 BMEI1750 Brucella melitensis bv. 1 str. 16M glycerol-3-phosphate regulon repressor NP_540667.1 1792386 R 224914 CDS NP_540668.1 17988034 1197462 complement(1793505..1794197) 1 NC_003317.1 two component response regulator 1794197 1197462 BMEI1751 Brucella melitensis bv. 1 str. 16M two component response regulator NP_540668.1 1793505 R 224914 CDS NP_540669.1 17988035 1197463 1794539..1795246 1 NC_003317.1 Crp/Fnr family transcriptional regulator 1795246 1197463 BMEI1752 Brucella melitensis bv. 1 str. 16M Crp/Fnr family transcriptional regulator NP_540669.1 1794539 D 224914 CDS NP_540670.1 17988036 1197464 complement(1795508..1796353) 1 NC_003317.1 3'-phosphoadenosine 5'-phosphosulfate 3'-phosphatase 1796353 1197464 BMEI1753 Brucella melitensis bv. 1 str. 16M 3'-phosphoadenosine 5'-phosphosulfate 3'-phosphatase NP_540670.1 1795508 R 224914 CDS NP_540671.1 17988037 1197465 complement(1796356..1798290) 1 NC_003317.1 in Rhizobium meliloti this protein is involved in the synthesis of nodulation factors that are active on the roots of alfalfa; catalyzes formation of activated sulfate intermediate; converts ATP and sulfate to diphosphate and adenylylsulfate and then ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; the activated intermediate is transferred to the nodulation factors by NodH; may interact with NodP and NodQ; similar to the CysD and CysN proteins from EScherichia coli involved in cysteine biosynthesis; bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase 1798290 1197465 BMEI1754 Brucella melitensis bv. 1 str. 16M bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase NP_540671.1 1796356 R 224914 CDS NP_540672.2 161511123 1197466 complement(1798290..1799192) 1 NC_003317.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP; sulfate adenylyltransferase subunit 2 1799192 1197466 BMEI1755 Brucella melitensis bv. 1 str. 16M sulfate adenylyltransferase subunit 2 NP_540672.2 1798290 R 224914 CDS NP_540673.1 17988039 1197467 1799371..1799616 1 NC_003317.1 hypothetical protein 1799616 1197467 BMEI1756 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540673.1 1799371 D 224914 CDS NP_540674.1 17988040 1197468 complement(1799595..1800965) 1 NC_003317.1 aminotransferase 1800965 1197468 BMEI1757 Brucella melitensis bv. 1 str. 16M aminotransferase NP_540674.1 1799595 R 224914 CDS NP_540675.1 17988041 1197469 complement(1801080..1801796) 1 NC_003317.1 LuxR family transcriptional regulator 1801796 1197469 BMEI1758 Brucella melitensis bv. 1 str. 16M LuxR family transcriptional regulator NP_540675.1 1801080 R 224914 CDS NP_540676.1 17988042 1197470 complement(1802108..1805893) 1 NC_003317.1 one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity; B12-dependent methionine synthase 1805893 metH 1197470 metH Brucella melitensis bv. 1 str. 16M B12-dependent methionine synthase NP_540676.1 1802108 R 224914 CDS NP_540677.1 17988043 1197471 1806030..1806596 1 NC_003317.1 hypothetical protein 1806596 1197471 BMEI1760 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540677.1 1806030 D 224914 CDS NP_540678.1 17988044 1197472 complement(1806649..1806861) 1 NC_003317.1 hypothetical protein 1806861 1197472 BMEI1761 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540678.1 1806649 R 224914 CDS NP_540679.1 17988045 1197473 1807062..1807730 1 NC_003317.1 O-6-methylguanine-DNA-alkyltransferase 1807730 1197473 BMEI1762 Brucella melitensis bv. 1 str. 16M O-6-methylguanine-DNA-alkyltransferase NP_540679.1 1807062 D 224914 CDS NP_540680.1 17988046 1197474 complement(1807731..1808024) 1 NC_003317.1 hypothetical protein 1808024 1197474 BMEI1763 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540680.1 1807731 R 224914 CDS NP_540681.1 17988047 1197475 complement(1808092..1808616) 1 NC_003317.1 oxidoreductase 1808616 1197475 BMEI1764 Brucella melitensis bv. 1 str. 16M oxidoreductase NP_540681.1 1808092 R 224914 CDS NP_540682.1 17988048 1197476 complement(1808669..1809427) 1 NC_003317.1 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite; phosphoadenosine phosphosulfate reductase 1809427 1197476 BMEI1765 Brucella melitensis bv. 1 str. 16M phosphoadenosine phosphosulfate reductase NP_540682.1 1808669 R 224914 CDS NP_540683.1 17988049 1197477 complement(1809328..1811091) 1 NC_003317.1 sulfite reductase (ferredoxin) 1811091 1197477 BMEI1766 Brucella melitensis bv. 1 str. 16M sulfite reductase (ferredoxin) NP_540683.1 1809328 R 224914 CDS NP_540684.1 17988050 1197478 complement(1811112..1811429) 1 NC_003317.1 hypothetical protein 1811429 1197478 BMEI1767 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540684.1 1811112 R 224914 CDS NP_540685.1 17988051 1197479 complement(1811432..1812859) 1 NC_003317.1 uroporphyrin-III C-methyltransferase 1812859 1197479 BMEI1768 Brucella melitensis bv. 1 str. 16M uroporphyrin-III C-methyltransferase NP_540685.1 1811432 R 224914 CDS NP_540686.1 17988052 1197480 complement(1813085..1813465) 1 NC_003317.1 hypothetical protein 1813465 1197480 BMEI1769 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540686.1 1813085 R 224914 CDS NP_540687.1 17988053 1197481 complement(1813462..1814373) 1 NC_003317.1 methyltransferase 1814373 1197481 BMEI1770 Brucella melitensis bv. 1 str. 16M methyltransferase NP_540687.1 1813462 R 224914 CDS NP_540688.1 17988054 1197482 complement(1814385..1815599) 1 NC_003317.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 1815599 1197482 BMEI1771 Brucella melitensis bv. 1 str. 16M coproporphyrinogen III oxidase NP_540688.1 1814385 R 224914 CDS NP_540689.1 17988055 1197483 complement(1815596..1816270) 1 NC_003317.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; deoxyribonucleotide triphosphate pyrophosphatase 1816270 1197483 BMEI1772 Brucella melitensis bv. 1 str. 16M deoxyribonucleotide triphosphate pyrophosphatase NP_540689.1 1815596 R 224914 CDS NP_540690.1 17988056 1197484 complement(1816261..1816482) 1 NC_003317.1 lactoylglutathione lyase 1816482 1197484 BMEI1773 Brucella melitensis bv. 1 str. 16M lactoylglutathione lyase NP_540690.1 1816261 R 224914 CDS NP_540691.1 17988057 1197485 complement(1816491..1816709) 1 NC_003317.1 lactoylglutathione lyase 1816709 1197485 BMEI1774 Brucella melitensis bv. 1 str. 16M lactoylglutathione lyase NP_540691.1 1816491 R 224914 CDS NP_540692.1 17988058 1197486 complement(1816838..1817554) 1 NC_003317.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH 1817554 rph 1197486 rph Brucella melitensis bv. 1 str. 16M ribonuclease PH NP_540692.1 1816838 R 224914 CDS NP_540693.1 17988059 1197487 1817722..1818846 1 NC_003317.1 Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons; heat-inducible transcription repressor 1818846 hrcA 1197487 hrcA Brucella melitensis bv. 1 str. 16M heat-inducible transcription repressor NP_540693.1 1817722 D 224914 CDS NP_540694.1 17988060 1197488 1819102..1819632 1 NC_003317.1 heat shock protein GrpE 1819632 1197488 BMEI1777 Brucella melitensis bv. 1 str. 16M heat shock protein GrpE NP_540694.1 1819102 D 224914 CDS NP_540695.1 17988061 1197489 1819708..1820421 1 NC_003317.1 transporter 1820421 1197489 BMEI1778 Brucella melitensis bv. 1 str. 16M transporter NP_540695.1 1819708 D 224914 CDS NP_540696.1 17988062 1197490 complement(1820440..1821432) 1 NC_003317.1 fructokinase 1821432 1197490 BMEI1779 Brucella melitensis bv. 1 str. 16M fructokinase NP_540696.1 1820440 R 224914 CDS NP_540697.1 17988063 1197491 1821507..1821695 1 NC_003317.1 hypothetical protein 1821695 1197491 BMEI1780 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540697.1 1821507 D 224914 CDS NP_540698.1 17988064 1197492 1821692..1822405 1 NC_003317.1 role in sulfur assimilation; CysZ-like protein 1822405 1197492 BMEI1781 Brucella melitensis bv. 1 str. 16M CysZ-like protein NP_540698.1 1821692 D 224914 CDS NP_540699.1 17988065 1197493 complement(1822446..1823192) 1 NC_003317.1 endonuclease III 1823192 1197493 BMEI1782 Brucella melitensis bv. 1 str. 16M endonuclease III NP_540699.1 1822446 R 224914 CDS NP_540700.1 17988066 1197494 1823255..1823794 1 NC_003317.1 hypothetical protein 1823794 1197494 BMEI1783 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540700.1 1823255 D 224914 CDS NP_540701.1 17988067 1197495 1824006..1824488 1 NC_003317.1 small heat shock protein HspA 1824488 1197495 BMEI1784 Brucella melitensis bv. 1 str. 16M small heat shock protein HspA NP_540701.1 1824006 D 224914 CDS NP_540702.1 17988068 1197496 1824579..1824839 1 NC_003317.1 hypothetical protein 1824839 1197496 BMEI1785 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540702.1 1824579 D 224914 CDS NP_540703.1 17988069 1197497 complement(1824920..1825384) 1 NC_003317.1 nitrogen regulatory IIA protein 1825384 1197497 BMEI1786 Brucella melitensis bv. 1 str. 16M nitrogen regulatory IIA protein NP_540703.1 1824920 R 224914 CDS NP_540704.1 17988070 1197498 complement(1825487..1826080) 1 NC_003317.1 sigma54 modulation protein /30S ribosomal protein S30P 1826080 1197498 BMEI1787 Brucella melitensis bv. 1 str. 16M sigma54 modulation protein /30S ribosomal protein S30P NP_540704.1 1825487 R 224914 CDS NP_540705.1 17988071 1197499 1826316..1826684 1 NC_003317.1 hypothetical protein 1826684 1197499 BMEI1788 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540705.1 1826316 D 224914 CDS NP_540706.1 17988072 1197500 complement(1826830..1828395) 1 NC_003317.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen; RNA polymerase factor sigma-54 1828395 1197500 BMEI1789 Brucella melitensis bv. 1 str. 16M RNA polymerase factor sigma-54 NP_540706.1 1826830 R 224914 CDS NP_540707.1 17988073 1197501 complement(1828628..1829461) 1 NC_003317.1 ABC transporter ATP-binding protein 1829461 1197501 BMEI1790 Brucella melitensis bv. 1 str. 16M ABC transporter ATP-binding protein NP_540707.1 1828628 R 224914 CDS NP_540708.1 17988074 1197502 complement(1829473..1829991) 1 NC_003317.1 hypothetical protein 1829991 1197502 BMEI1791 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540708.1 1829473 R 224914 CDS NP_540709.1 17988075 1197503 complement(1830411..1831064) 1 NC_003317.1 hypothetical protein 1831064 1197503 BMEI1792 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540709.1 1830411 R 224914 CDS NP_540710.1 17988076 1197504 1831673..1832578 1 NC_003317.1 protease IV 1832578 1197504 BMEI1793 Brucella melitensis bv. 1 str. 16M protease IV NP_540710.1 1831673 D 224914 CDS NP_540711.1 17988077 1197505 1832604..1832909 1 NC_003317.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit beta 1832909 ihfB 1197505 ihfB Brucella melitensis bv. 1 str. 16M integration host factor subunit beta NP_540711.1 1832604 D 224914 CDS NP_540712.1 17988078 1197506 1832955..1833242 1 NC_003317.1 hypothetical protein 1833242 1197506 BMEI1795 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540712.1 1832955 D 224914 CDS NP_540713.1 17988079 1197507 1833355..1834044 1 NC_003317.1 methyltransferase 1834044 1197507 BMEI1796 Brucella melitensis bv. 1 str. 16M methyltransferase NP_540713.1 1833355 D 224914 CDS NP_540714.1 17988080 1197508 1833978..1834499 1 NC_003317.1 methyltransferase 1834499 1197508 BMEI1797 Brucella melitensis bv. 1 str. 16M methyltransferase NP_540714.1 1833978 D 224914 CDS NP_540715.1 17988081 1197509 1834496..1835389 1 NC_003317.1 23S rRNA methyltransferase RumA 1835389 1197509 BMEI1798 Brucella melitensis bv. 1 str. 16M 23S rRNA methyltransferase RumA NP_540715.1 1834496 D 224914 CDS NP_540716.1 17988082 1197510 1835358..1835873 1 NC_003317.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 1835873 1197510 BMEI1799 Brucella melitensis bv. 1 str. 16M lipoprotein signal peptidase NP_540716.1 1835358 D 224914 CDS NP_540717.1 17988083 1197511 1836195..1837040 1 NC_003317.1 hypothetical protein 1837040 1197511 BMEI1800 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540717.1 1836195 D 224914 CDS NP_540718.1 17988084 1197512 complement(1837346..1840093) 1 NC_003317.1 This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 1840093 1197512 BMEI1801 Brucella melitensis bv. 1 str. 16M DNA mismatch repair protein MutS NP_540718.1 1837346 R 224914 CDS NP_540719.1 17988085 1197513 1840235..1841635 1 NC_003317.1 NADP-dependent malic enzyme 1841635 1197513 BMEI1802 Brucella melitensis bv. 1 str. 16M NADP-dependent malic enzyme NP_540719.1 1840235 D 224914 CDS NP_540720.1 17988086 1197514 1841413..1842528 1 NC_003317.1 NADP-dependent malic enzyme 1842528 1197514 BMEI1803 Brucella melitensis bv. 1 str. 16M NADP-dependent malic enzyme NP_540720.1 1841413 D 224914 CDS NP_540721.1 17988087 1197515 1842671..1845475 1 NC_003317.1 catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein; PII uridylyl-transferase 1845475 1197515 BMEI1804 Brucella melitensis bv. 1 str. 16M PII uridylyl-transferase NP_540721.1 1842671 D 224914 CDS NP_540722.1 17988088 1197516 1845411..1847078 1 NC_003317.1 virulence factor MVIN 1847078 1197516 BMEI1805 Brucella melitensis bv. 1 str. 16M virulence factor MVIN NP_540722.1 1845411 D 224914 CDS NP_540723.2 161511122 1197517 1847175..1848242 1 NC_003317.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase 1848242 1197517 BMEI1806 Brucella melitensis bv. 1 str. 16M tryptophanyl-tRNA synthetase NP_540723.2 1847175 D 224914 CDS NP_540724.1 17988090 1197518 1848249..1848788 1 NC_003317.1 hypothetical protein 1848788 1197518 BMEI1807 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540724.1 1848249 D 224914 CDS NP_540725.1 17988091 1197519 1848897..1849469 1 NC_003317.1 NifU protein 1849469 1197519 BMEI1808 Brucella melitensis bv. 1 str. 16M NifU protein NP_540725.1 1848897 D 224914 CDS NP_540726.1 17988092 1197520 complement(1849559..1850179) 1 NC_003317.1 hypothetical protein 1850179 1197520 BMEI1809 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540726.1 1849559 R 224914 CDS NP_540727.1 17988093 1197521 1850449..1850943 1 NC_003317.1 hypothetical protein 1850943 1197521 BMEI1810 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540727.1 1850449 D 224914 CDS NP_540728.1 17988094 1197522 complement(1850949..1851512) 1 NC_003317.1 acid tolerance regulatory protein ACTR 1851512 1197522 BMEI1811 Brucella melitensis bv. 1 str. 16M acid tolerance regulatory protein ACTR NP_540728.1 1850949 R 224914 CDS NP_540729.1 17988095 1197523 1851472..1851675 1 NC_003317.1 hypothetical protein 1851675 1197523 BMEI1812 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540729.1 1851472 D 224914 CDS NP_540730.1 17988096 1197524 complement(1851762..1852046) 1 NC_003317.1 hypothetical protein 1852046 1197524 BMEI1813 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540730.1 1851762 R 224914 CDS NP_540731.1 17988097 1197525 complement(1852112..1852504) 1 NC_003317.1 transposase 1852504 1197525 BMEI1814 Brucella melitensis bv. 1 str. 16M transposase NP_540731.1 1852112 R 224914 CDS NP_540732.1 17988098 1197526 complement(1852501..1852869) 1 NC_003317.1 transposase 1852869 1197526 BMEI1815 Brucella melitensis bv. 1 str. 16M transposase NP_540732.1 1852501 R 224914 CDS NP_540733.1 17988099 1197527 complement(1852939..1854162) 1 NC_003317.1 sensory transduction protein kinase 1854162 1197527 BMEI1816 Brucella melitensis bv. 1 str. 16M sensory transduction protein kinase NP_540733.1 1852939 R 224914 CDS NP_540734.1 17988100 1197528 complement(1854326..1855162) 1 NC_003317.1 ATP-dependent helicase HRPB 1855162 1197528 BMEI1817 Brucella melitensis bv. 1 str. 16M ATP-dependent helicase HRPB NP_540734.1 1854326 R 224914 CDS NP_540735.1 17988101 1197529 complement(1854924..1857056) 1 NC_003317.1 ATP-dependent helicase HRPB 1857056 1197529 BMEI1818 Brucella melitensis bv. 1 str. 16M ATP-dependent helicase HRPB NP_540735.1 1854924 R 224914 CDS NP_540736.1 17988102 1197530 1857226..1858338 1 NC_003317.1 alcohol dehydrogenase 1858338 1197530 BMEI1819 Brucella melitensis bv. 1 str. 16M alcohol dehydrogenase NP_540736.1 1857226 D 224914 CDS NP_540737.1 17988103 1197531 1858338..1858754 1 NC_003317.1 acetyltransferase 1858754 1197531 BMEI1820 Brucella melitensis bv. 1 str. 16M acetyltransferase NP_540737.1 1858338 D 224914 CDS NP_540738.1 17988104 1197532 1858806..1859462 1 NC_003317.1 hypothetical protein 1859462 1197532 BMEI1821 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540738.1 1858806 D 224914 CDS NP_540739.1 17988105 1197533 1859452..1860306 1 NC_003317.1 S-formylglutathione hydrolase 1860306 1197533 BMEI1822 Brucella melitensis bv. 1 str. 16M S-formylglutathione hydrolase NP_540739.1 1859452 D 224914 CDS NP_540740.1 17988106 1197534 1860625..1863066 1 NC_003317.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 1863066 gyrB 1197534 gyrB Brucella melitensis bv. 1 str. 16M DNA gyrase subunit B NP_540740.1 1860625 D 224914 CDS NP_540741.1 17988107 1197535 complement(1863162..1865042) 1 NC_003317.1 ATP-dependent RNA helicase DeaD 1865042 1197535 BMEI1824 Brucella melitensis bv. 1 str. 16M ATP-dependent RNA helicase DeaD NP_540741.1 1863162 R 224914 CDS NP_540742.1 17988108 1197536 complement(1865184..1868168) 1 NC_003317.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 1868168 1197536 BMEI1825 Brucella melitensis bv. 1 str. 16M DNA polymerase I NP_540742.1 1865184 R 224914 CDS NP_540743.1 17988109 1197537 complement(1868202..1868450) 1 NC_003317.1 hypothetical protein 1868450 1197537 BMEI1826 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540743.1 1868202 R 224914 CDS NP_540744.1 17988110 1197538 1868645..1870096 1 NC_003317.1 hypothetical protein 1870096 1197538 BMEI1827 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540744.1 1868645 D 224914 CDS NP_540745.1 17988111 1197539 1870135..1870752 1 NC_003317.1 ribonuclease D 1870752 1197539 BMEI1828 Brucella melitensis bv. 1 str. 16M ribonuclease D NP_540745.1 1870135 D 224914 CDS NP_540746.1 17988112 1197540 1870984..1871670 1 NC_003317.1 hypothetical protein 1871670 1197540 BMEI1829 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540746.1 1870984 D 224914 CDS NP_540747.1 17988113 1197541 1871937..1872629 1 NC_003317.1 hypothetical protein 1872629 1197541 BMEI1830 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540747.1 1871937 D 224914 CDS NP_540748.1 17988114 1197542 1872934..1875126 1 NC_003317.1 penicillin-binding protein 1A 1875126 1197542 BMEI1831 Brucella melitensis bv. 1 str. 16M penicillin-binding protein 1A NP_540748.1 1872934 D 224914 CDS NP_540749.1 17988115 1197543 1875214..1876053 1 NC_003317.1 short-chain dehydrogenase/reductase 1876053 1197543 BMEI1832 Brucella melitensis bv. 1 str. 16M short-chain dehydrogenase/reductase NP_540749.1 1875214 D 224914 CDS NP_540750.1 17988116 1197544 1876144..1877070 1 NC_003317.1 fructokinase 1877070 1197544 BMEI1833 Brucella melitensis bv. 1 str. 16M fructokinase NP_540750.1 1876144 D 224914 CDS NP_540751.1 17988117 1197545 1877093..1877881 1 NC_003317.1 ubiquinone/menaquinone biosynthesis methyltransferase UBIE 1877881 1197545 BMEI1834 Brucella melitensis bv. 1 str. 16M ubiquinone/menaquinone biosynthesis methyltransferase UBIE NP_540751.1 1877093 D 224914 CDS NP_540752.1 17988118 1197546 1877991..1878821 1 NC_003317.1 N-methyl-D-aspartate receptor 1878821 1197546 BMEI1835 Brucella melitensis bv. 1 str. 16M N-methyl-D-aspartate receptor NP_540752.1 1877991 D 224914 CDS NP_540753.1 17988119 1197547 complement(1878863..1880167) 1 NC_003317.1 catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase 1880167 1197547 BMEI1836 Brucella melitensis bv. 1 str. 16M nicotinate phosphoribosyltransferase NP_540753.1 1878863 R 224914 CDS NP_540754.1 17988120 1197548 complement(1880257..1888860) 1 NC_003317.1 cellobiose-phosphorylase 1888860 1197548 BMEI1837 Brucella melitensis bv. 1 str. 16M cellobiose-phosphorylase NP_540754.1 1880257 R 224914 CDS NP_540755.1 17988121 1197549 complement(1889246..1890460) 1 NC_003317.1 sulfate transport ATP-binding protein CYSA 1890460 1197549 BMEI1838 Brucella melitensis bv. 1 str. 16M sulfate transport ATP-binding protein CYSA NP_540755.1 1889246 R 224914 CDS NP_540756.1 17988122 1197550 complement(1890423..1891160) 1 NC_003317.1 sulfate transport system permease protein CYSW 1891160 1197550 BMEI1839 Brucella melitensis bv. 1 str. 16M sulfate transport system permease protein CYSW NP_540756.1 1890423 R 224914 CDS NP_540757.1 17988123 1197551 complement(1891279..1892145) 1 NC_003317.1 sulfate transport system permease protein cysT 1892145 1197551 BMEI1840 Brucella melitensis bv. 1 str. 16M sulfate transport system permease protein cysT NP_540757.1 1891279 R 224914 CDS NP_540758.1 17988124 1197552 complement(1892240..1893223) 1 NC_003317.1 sulfate-binding protein 1893223 1197552 BMEI1841 Brucella melitensis bv. 1 str. 16M sulfate-binding protein NP_540758.1 1892240 R 224914 CDS NP_540759.1 17988125 1197553 complement(1893546..1894337) 1 NC_003317.1 hypothetical protein 1894337 1197553 BMEI1842 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540759.1 1893546 R 224914 CDS NP_540760.1 17988126 1197554 1894437..1895141 1 NC_003317.1 hypothetical protein 1895141 1197554 BMEI1843 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540760.1 1894437 D 224914 CDS NP_540761.1 17988127 1197555 complement(1895227..1895631) 1 NC_003317.1 hypothetical protein 1895631 1197555 BMEI1844 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540761.1 1895227 R 224914 CDS NP_540762.1 17988128 1197556 1896284..1896520 1 NC_003317.1 AsnC family transcriptional regulator 1896520 1197556 BMEI1845 Brucella melitensis bv. 1 str. 16M AsnC family transcriptional regulator NP_540762.1 1896284 D 224914 CDS NP_540763.1 17988129 1197557 1896619..1897071 1 NC_003317.1 response regulator receiver protein ExsF 1897071 1197557 BMEI1846 Brucella melitensis bv. 1 str. 16M response regulator receiver protein ExsF NP_540763.1 1896619 D 224914 CDS NP_540764.1 17988130 1197558 1897098..1897529 1 NC_003317.1 hypothetical protein 1897529 1197558 BMEI1847 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540764.1 1897098 D 224914 CDS NP_540765.1 17988131 1197559 1897914..1899755 1 NC_003317.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 1899755 1197559 BMEI1848 Brucella melitensis bv. 1 str. 16M dihydroxy-acid dehydratase NP_540765.1 1897914 D 224914 CDS NP_540766.1 17988132 1197560 complement(1900004..1900615) 1 NC_003317.1 thiol:disulfide interchange protein CYCY precursor 1900615 1197560 BMEI1849 Brucella melitensis bv. 1 str. 16M thiol:disulfide interchange protein CYCY precursor NP_540766.1 1900004 R 224914 CDS NP_540767.1 17988133 1197561 complement(1900612..1900785) 1 NC_003317.1 heme exporter protein D 1900785 1197561 BMEI1850 Brucella melitensis bv. 1 str. 16M heme exporter protein D NP_540767.1 1900612 R 224914 CDS NP_540768.1 17988134 1197562 complement(1900782..1901570) 1 NC_003317.1 heme exporter protein C 1901570 1197562 BMEI1851 Brucella melitensis bv. 1 str. 16M heme exporter protein C NP_540768.1 1900782 R 224914 CDS NP_540769.1 17988135 1197563 complement(1901625..1902290) 1 NC_003317.1 heme exporter protein B 1902290 1197563 BMEI1852 Brucella melitensis bv. 1 str. 16M heme exporter protein B NP_540769.1 1901625 R 224914 CDS NP_540770.1 17988136 1197564 complement(1902290..1902958) 1 NC_003317.1 ATP-binding protein; required for proper cytochrome c maturation; cytochrome c biogenesis protein CcmA 1902958 1197564 BMEI1853 Brucella melitensis bv. 1 str. 16M cytochrome c biogenesis protein CcmA NP_540770.1 1902290 R 224914 CDS NP_540771.1 17988137 1197565 complement(1903100..1903312) 1 NC_003317.1 hypothetical protein 1903312 1197565 BMEI1854 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540771.1 1903100 R 224914 CDS NP_540772.1 17988138 1197566 1903281..1905968 1 NC_003317.1 Catalyzes the conversion of citrate to isocitrate; aconitate hydratase 1905968 1197566 BMEI1855 Brucella melitensis bv. 1 str. 16M aconitate hydratase NP_540772.1 1903281 D 224914 CDS NP_540773.1 17988139 1197567 1906215..1906979 1 NC_003317.1 hypothetical protein 1906979 1197567 BMEI1856 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540773.1 1906215 D 224914 CDS NP_540774.1 17988140 1197568 1907529..1907930 1 NC_003317.1 hypothetical protein 1907930 1197568 BMEI1857 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540774.1 1907529 D 224914 CDS NP_540775.1 17988141 1197569 complement(1907950..1908489) 1 NC_003317.1 phosphinothricin N-acetyltransferase 1908489 1197569 BMEI1858 Brucella melitensis bv. 1 str. 16M phosphinothricin N-acetyltransferase NP_540775.1 1907950 R 224914 CDS NP_540776.1 17988142 1197570 complement(1908604..1909341) 1 NC_003317.1 hypothetical protein 1909341 1197570 BMEI1859 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540776.1 1908604 R 224914 CDS NP_540777.1 17988143 1197571 complement(1909575..1912127) 1 NC_003317.1 transmembrane oxidoreductase 1912127 1197571 BMEI1860 Brucella melitensis bv. 1 str. 16M transmembrane oxidoreductase NP_540777.1 1909575 R 224914 CDS NP_540778.1 17988144 1197572 1913061..1913723 1 NC_003317.1 arylesterase 1913723 1197572 BMEI1861 Brucella melitensis bv. 1 str. 16M arylesterase NP_540778.1 1913061 D 224914 CDS NP_540779.1 17988145 1197573 1913904..1914494 1 NC_003317.1 2'-5' RNA ligase 1914494 1197573 BMEI1862 Brucella melitensis bv. 1 str. 16M 2'-5' RNA ligase NP_540779.1 1913904 D 224914 CDS NP_540780.1 17988146 1197574 complement(1914404..1915009) 1 NC_003317.1 low molecular weight phosphotyrosine protein phosphatase 1915009 1197574 BMEI1863 Brucella melitensis bv. 1 str. 16M low molecular weight phosphotyrosine protein phosphatase NP_540780.1 1914404 R 224914 CDS NP_540781.1 17988147 1197575 1915236..1915529 1 NC_003317.1 4-alpha-hydroxytetrahydrobiopterin dehydratase activity; catalyzes the formation of (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7, 8-dihydro-6H-pterin from (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7, 8-tetrahydro-4a-hydroxypterin; functions in recycling tetrahydrobiopterin (BH4) in phenylalanine hydroxylase reaction; pterin-4-alpha-carbinolamine dehydratase 1915529 phhB 1197575 phhB Brucella melitensis bv. 1 str. 16M pterin-4-alpha-carbinolamine dehydratase NP_540781.1 1915236 D 224914 CDS NP_540782.1 17988148 1197576 1915617..1916000 1 NC_003317.1 hypothetical protein 1916000 1197576 BMEI1865 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540782.1 1915617 D 224914 CDS NP_540783.1 17988149 1197577 1916377..1916919 1 NC_003317.1 hypothetical protein 1916919 1197577 BMEI1866 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540783.1 1916377 D 224914 CDS NP_540784.1 17988150 1197578 1917179..1918414 1 NC_003317.1 florfenicol resistance protein 1918414 1197578 BMEI1867 Brucella melitensis bv. 1 str. 16M florfenicol resistance protein NP_540784.1 1917179 D 224914 CDS NP_540785.1 17988151 1197579 1918670..1918951 1 NC_003317.1 hypothetical protein 1918951 1197579 BMEI1868 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540785.1 1918670 D 224914 CDS NP_540786.1 17988152 1197580 complement(1918955..1919704) 1 NC_003317.1 homoserine/homoserine lactone efflux protein 1919704 1197580 BMEI1869 Brucella melitensis bv. 1 str. 16M homoserine/homoserine lactone efflux protein NP_540786.1 1918955 R 224914 CDS NP_540787.1 17988153 1197581 1919801..1921021 1 NC_003317.1 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming; argininosuccinate synthase 1921021 1197581 BMEI1870 Brucella melitensis bv. 1 str. 16M argininosuccinate synthase NP_540787.1 1919801 D 224914 CDS NP_540788.1 17988154 1197582 complement(1921100..1921837) 1 NC_003317.1 hypothetical protein 1921837 1197582 BMEI1871 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540788.1 1921100 R 224914 CDS NP_540789.1 17988155 1197583 complement(1921857..1922954) 1 NC_003317.1 cell surface protein 1922954 1197583 BMEI1872 Brucella melitensis bv. 1 str. 16M cell surface protein NP_540789.1 1921857 R 224914 CDS NP_540790.1 17988156 1197584 complement(1922890..1924407) 1 NC_003317.1 cell surface protein 1924407 1197584 BMEI1873 Brucella melitensis bv. 1 str. 16M cell surface protein NP_540790.1 1922890 R 224914 CDS NP_540791.1 17988157 1197585 1924971..1925801 1 NC_003317.1 hypothetical protein 1925801 1197585 BMEI1874 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540791.1 1924971 D 224914 CDS NP_540792.1 17988158 1197586 1925551..1927278 1 NC_003317.1 hypothetical protein 1927278 1197586 BMEI1875 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540792.1 1925551 D 224914 CDS NP_540793.1 17988159 1197587 1927275..1930511 1 NC_003317.1 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis. It is not the major replicative DNA polymerase.; error-prone DNA polymerase 1930511 dnaE2 1197587 dnaE2 Brucella melitensis bv. 1 str. 16M error-prone DNA polymerase NP_540793.1 1927275 D 224914 CDS NP_540794.1 17988160 1197588 complement(1930652..1931308) 1 NC_003317.1 hemolysin III 1931308 1197588 BMEI1877 Brucella melitensis bv. 1 str. 16M hemolysin III NP_540794.1 1930652 R 224914 CDS NP_540795.1 17988161 1197589 complement(1931490..1932011) 1 NC_003317.1 soluble lytic murein transglycosylase 1932011 1197589 BMEI1878 Brucella melitensis bv. 1 str. 16M soluble lytic murein transglycosylase NP_540795.1 1931490 R 224914 CDS NP_540796.1 17988162 1197590 complement(1932369..1932557) 1 NC_003317.1 hypothetical protein 1932557 1197590 BMEI1879 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540796.1 1932369 R 224914 CDS NP_540797.1 17988163 1197591 complement(1932723..1932932) 1 NC_003317.1 hypothetical protein 1932932 1197591 BMEI1880 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540797.1 1932723 R 224914 CDS NP_540798.1 17988164 1197592 complement(1933000..1933167) 1 NC_003317.1 hypothetical protein 1933167 1197592 BMEI1881 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540798.1 1933000 R 224914 CDS NP_540799.1 17988165 1197593 complement(1933211..1933900) 1 NC_003317.1 fumarylpyruvate hydrolase 1933900 1197593 BMEI1882 Brucella melitensis bv. 1 str. 16M fumarylpyruvate hydrolase NP_540799.1 1933211 R 224914 CDS NP_540800.1 17988166 1197594 complement(1934000..1934641) 1 NC_003317.1 fructose transport system kinase 1934641 frcK 1197594 frcK Brucella melitensis bv. 1 str. 16M fructose transport system kinase NP_540800.1 1934000 R 224914 CDS NP_540801.1 17988167 1197595 complement(1934771..1935694) 1 NC_003317.1 dienelactone hydrolase 1935694 1197595 BMEI1884 Brucella melitensis bv. 1 str. 16M dienelactone hydrolase NP_540801.1 1934771 R 224914 CDS NP_540802.1 17988168 1197596 1935819..1936712 1 NC_003317.1 LysR family transcriptional regulator 1936712 1197596 BMEI1885 Brucella melitensis bv. 1 str. 16M LysR family transcriptional regulator NP_540802.1 1935819 D 224914 CDS NP_540803.1 17988169 1197597 1936859..1938559 1 NC_003317.1 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; phosphoglucomutase 1938559 1197597 BMEI1886 Brucella melitensis bv. 1 str. 16M phosphoglucomutase NP_540803.1 1936859 D 224914 CDS NP_540804.1 17988170 1197598 complement(1938740..1939924) 1 NC_003317.1 ATPase 1939924 1197598 BMEI1887 Brucella melitensis bv. 1 str. 16M ATPase NP_540804.1 1938740 R 224914 CDS NP_540805.1 17988171 1197599 1940100..1940495 1 NC_003317.1 lactoylglutathione lyase 1940495 1197599 BMEI1888 Brucella melitensis bv. 1 str. 16M lactoylglutathione lyase NP_540805.1 1940100 D 224914 CDS NP_540806.1 17988172 1197600 1940796..1941146 1 NC_003317.1 hypothetical protein 1941146 1197600 BMEI1889 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540806.1 1940796 D 224914 CDS NP_540807.1 17988173 1197601 1941317..1942285 1 NC_003317.1 transporter 1942285 1197601 BMEI1890 Brucella melitensis bv. 1 str. 16M transporter NP_540807.1 1941317 D 224914 CDS NP_540808.1 17988174 1197602 1942296..1942502 1 NC_003317.1 hypothetical protein 1942502 1197602 BMEI1891 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540808.1 1942296 D 224914 CDS NP_540809.1 17988175 1197603 1942821..1943342 1 NC_003317.1 hypothetical protein 1943342 1197603 BMEI1892 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540809.1 1942821 D 224914 CDS NP_540810.1 17988176 1197604 complement(1943678..1944289) 1 NC_003317.1 hypothetical protein 1944289 1197604 BMEI1893 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540810.1 1943678 R 224914 CDS NP_540811.1 17988177 1197605 complement(1944548..1949203) 1 NC_003317.1 gramicidin S biosynthesis grsT protein 1949203 1197605 BMEI1894 Brucella melitensis bv. 1 str. 16M gramicidin S biosynthesis grsT protein NP_540811.1 1944548 R 224914 CDS NP_540812.1 17988178 1197606 complement(1949284..1951155) 1 NC_003317.1 hypothetical protein 1951155 1197606 BMEI1895 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540812.1 1949284 R 224914 CDS NP_540813.1 17988179 1197607 complement(1951688..1952203) 1 NC_003317.1 hypothetical protein 1952203 1197607 BMEI1896 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540813.1 1951688 R 224914 CDS NP_540814.1 17988180 1197608 1952562..1952807 1 NC_003317.1 hypothetical protein 1952807 1197608 BMEI1897 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540814.1 1952562 D 224914 CDS NP_540815.1 17988181 1197609 complement(1952838..1953284) 1 NC_003317.1 cytochrome O ubiquinol oxidase operon protein CYOD 1953284 1197609 BMEI1898 Brucella melitensis bv. 1 str. 16M cytochrome O ubiquinol oxidase operon protein CYOD NP_540815.1 1952838 R 224914 CDS NP_540816.1 17988182 1197610 complement(1953203..1953832) 1 NC_003317.1 cytochrome O ubiquinol oxidase subunit III 1953832 1197610 BMEI1899 Brucella melitensis bv. 1 str. 16M cytochrome O ubiquinol oxidase subunit III NP_540816.1 1953203 R 224914 CDS NP_540817.1 17988183 1197611 complement(1953836..1955815) 1 NC_003317.1 cytochrome O ubiquinol oxidase subunit I 1955815 1197611 BMEI1900 Brucella melitensis bv. 1 str. 16M cytochrome O ubiquinol oxidase subunit I NP_540817.1 1953836 R 224914 CDS NP_540818.1 17988184 1197612 complement(1955895..1956929) 1 NC_003317.1 cytochrome O ubiquinol oxidase subunit II 1956929 1197612 BMEI1901 Brucella melitensis bv. 1 str. 16M cytochrome O ubiquinol oxidase subunit II NP_540818.1 1955895 R 224914 CDS NP_540819.1 17988185 1197613 1957447..1958412 1 NC_003317.1 molybdopterin biosynthesis protein 1958412 1197613 BMEI1902 Brucella melitensis bv. 1 str. 16M molybdopterin biosynthesis protein NP_540819.1 1957447 D 224914 CDS NP_540820.1 17988186 1197614 complement(1958457..1959065) 1 NC_003317.1 cytochrome c-552 1959065 1197614 BMEI1903 Brucella melitensis bv. 1 str. 16M cytochrome c-552 NP_540820.1 1958457 R 224914 CDS NP_540821.2 161511121 1197615 1959443..1960198 1 NC_003317.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase 1960198 1197615 BMEI1904 Brucella melitensis bv. 1 str. 16M 3-deoxy-manno-octulosonate cytidylyltransferase NP_540821.2 1959443 D 224914 CDS NP_540822.1 17988188 1197616 1960278..1961150 1 NC_003317.1 catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; prephenate dehydratase 1961150 1197616 BMEI1905 Brucella melitensis bv. 1 str. 16M prephenate dehydratase NP_540822.1 1960278 D 224914 CDS NP_540823.1 17988189 1197617 complement(1961180..1962067) 1 NC_003317.1 phosphohydrolase 1962067 1197617 BMEI1906 Brucella melitensis bv. 1 str. 16M phosphohydrolase NP_540823.1 1961180 R 224914 CDS NP_540824.1 17988190 1197618 complement(1962126..1962530) 1 NC_003317.1 hit1 protein 1962530 1197618 BMEI1907 Brucella melitensis bv. 1 str. 16M hit1 protein NP_540824.1 1962126 R 224914 CDS NP_540825.1 17988191 1197619 1962812..1964620 1 NC_003317.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 1964620 1197619 BMEI1908 Brucella melitensis bv. 1 str. 16M DNA polymerase III subunits gamma and tau NP_540825.1 1962812 D 224914 CDS NP_540826.1 17988192 1197620 1964645..1964968 1 NC_003317.1 hypothetical protein 1964968 1197620 BMEI1909 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540826.1 1964645 D 224914 CDS NP_540827.1 17988193 1197621 1965030..1965704 1 NC_003317.1 involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 1965704 recR 1197621 recR Brucella melitensis bv. 1 str. 16M recombination protein RecR NP_540827.1 1965030 D 224914 CDS NP_540828.1 17988194 1197622 1965720..1967003 1 NC_003317.1 membrane-bound lytic murein transglycosylase B 1967003 1197622 BMEI1911 Brucella melitensis bv. 1 str. 16M membrane-bound lytic murein transglycosylase B NP_540828.1 1965720 D 224914 CDS NP_540829.1 17988195 1197623 1967039..1967608 1 NC_003317.1 sugar transporter 1967608 1197623 BMEI1912 Brucella melitensis bv. 1 str. 16M sugar transporter NP_540829.1 1967039 D 224914 CDS NP_540830.1 17988196 1197624 complement(1967609..1968508) 1 NC_003317.1 LysR family transcriptional regulator 1968508 1197624 BMEI1913 Brucella melitensis bv. 1 str. 16M LysR family transcriptional regulator NP_540830.1 1967609 R 224914 CDS NP_540831.1 17988197 1197625 1968561..1969634 1 NC_003317.1 hypothetical protein 1969634 1197625 BMEI1914 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540831.1 1968561 D 224914 CDS NP_540832.2 161511120 1197626 complement(1970052..1971752) 1 NC_003317.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 1971752 rpsA 1197626 rpsA Brucella melitensis bv. 1 str. 16M 30S ribosomal protein S1 NP_540832.2 1970052 R 224914 CDS NP_540833.1 17988199 1197627 complement(1971968..1972627) 1 NC_003317.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 1972627 cmk 1197627 cmk Brucella melitensis bv. 1 str. 16M cytidylate kinase NP_540833.1 1971968 R 224914 CDS NP_540834.1 17988200 1197628 complement(1972624..1974066) 1 NC_003317.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 1974066 1197628 BMEI1917 Brucella melitensis bv. 1 str. 16M 3-phosphoshikimate 1-carboxyvinyltransferase NP_540834.1 1972624 R 224914 CDS NP_540835.1 17988201 1197629 1974361..1974744 1 NC_003317.1 hypothetical protein 1974744 1197629 BMEI1918 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540835.1 1974361 D 224914 CDS NP_540836.1 17988202 1197630 1975267..1976388 1 NC_003317.1 acyltransferase 1976388 1197630 BMEI1919 Brucella melitensis bv. 1 str. 16M acyltransferase NP_540836.1 1975267 D 224914 CDS NP_540837.1 17988203 1197631 1976613..1976999 1 NC_003317.1 hypothetical protein 1976999 1197631 BMEI1920 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540837.1 1976613 D 224914 CDS NP_540838.1 17988204 1197632 1977184..1978164 1 NC_003317.1 acetoacetyl-CoA synthetase 1978164 1197632 BMEI1921 Brucella melitensis bv. 1 str. 16M acetoacetyl-CoA synthetase NP_540838.1 1977184 D 224914 CDS NP_540839.1 17988205 1197633 1978165..1979172 1 NC_003317.1 acetoacetyl-CoA synthetase 1979172 1197633 BMEI1922 Brucella melitensis bv. 1 str. 16M acetoacetyl-CoA synthetase NP_540839.1 1978165 D 224914 CDS NP_540840.1 17988206 1197634 1979349..1980497 1 NC_003317.1 isovaleryl-CoA dehydrogenase 1980497 1197634 BMEI1923 Brucella melitensis bv. 1 str. 16M isovaleryl-CoA dehydrogenase NP_540840.1 1979349 D 224914 CDS NP_540841.1 17988207 1197635 1980497..1982104 1 NC_003317.1 methylcrotonyl-CoA carboxylase 1982104 1197635 BMEI1924 Brucella melitensis bv. 1 str. 16M methylcrotonyl-CoA carboxylase NP_540841.1 1980497 D 224914 CDS NP_540842.1 17988208 1197636 1982101..1984137 1 NC_003317.1 acetyl-CoA carboxylase subunit alpha / propionyl-CoA carboxylase subunit alpha 1984137 1197636 BMEI1925 Brucella melitensis bv. 1 str. 16M acetyl-CoA carboxylase subunit alpha / propionyl-CoA carboxylase subunit alpha NP_540842.1 1982101 D 224914 CDS NP_540843.1 17988209 1197637 1984130..1984993 1 NC_003317.1 catalyzes the formation of acetoacetate and acetyl-CoA from 3-hydroxy-3-methylglutaryl-CoA; hydroxymethylglutaryl-CoA lyase 1984993 1197637 BMEI1926 Brucella melitensis bv. 1 str. 16M hydroxymethylglutaryl-CoA lyase NP_540843.1 1984130 D 224914 CDS NP_540844.1 17988210 1197638 1984990..1985418 1 NC_003317.1 enoyl-CoA hydratase 1985418 1197638 BMEI1927 Brucella melitensis bv. 1 str. 16M enoyl-CoA hydratase NP_540844.1 1984990 D 224914 CDS NP_540845.1 17988211 1197639 1985355..1986014 1 NC_003317.1 enoyl-CoA hydratase 1986014 1197639 BMEI1928 Brucella melitensis bv. 1 str. 16M enoyl-CoA hydratase NP_540845.1 1985355 D 224914 CDS NP_540846.1 17988212 1197640 complement(1986073..1986294) 1 NC_003317.1 hypothetical protein 1986294 1197640 BMEI1929 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540846.1 1986073 R 224914 CDS NP_540847.1 17988213 1197641 1986251..1987357 1 NC_003317.1 leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein precursor 1987357 1197641 BMEI1930 Brucella melitensis bv. 1 str. 16M leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein precursor NP_540847.1 1986251 D 224914 CDS NP_540848.1 17988214 1197642 1987622..1987972 1 NC_003317.1 hypothetical protein 1987972 1197642 BMEI1931 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540848.1 1987622 D 224914 CDS NP_540849.1 17988215 1197643 1988012..1988212 1 NC_003317.1 hypothetical protein 1988212 1197643 BMEI1932 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540849.1 1988012 D 224914 CDS NP_540850.1 17988216 1197644 1988258..1988581 1 NC_003317.1 hypothetical protein 1988581 1197644 BMEI1933 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540850.1 1988258 D 224914 CDS NP_540851.1 17988217 1197645 1988812..1990680 1 NC_003317.1 periplasmic oligopeptide-binding protein 1990680 1197645 BMEI1934 Brucella melitensis bv. 1 str. 16M periplasmic oligopeptide-binding protein NP_540851.1 1988812 D 224914 CDS NP_540852.1 17988218 1197646 1990694..1992532 1 NC_003317.1 oligopeptide-binding protein appa 1992532 1197646 BMEI1935 Brucella melitensis bv. 1 str. 16M oligopeptide-binding protein appa NP_540852.1 1990694 D 224914 CDS NP_540853.1 17988219 1197647 1992644..1993741 1 NC_003317.1 oligopeptide transport system permease OppB 1993741 1197647 BMEI1936 Brucella melitensis bv. 1 str. 16M oligopeptide transport system permease OppB NP_540853.1 1992644 D 224914 CDS NP_540854.1 17988220 1197648 1993738..1994880 1 NC_003317.1 oligopeptide transport system permease protein OPPC 1994880 1197648 BMEI1937 Brucella melitensis bv. 1 str. 16M oligopeptide transport system permease protein OPPC NP_540854.1 1993738 D 224914 CDS NP_540855.1 17988221 1197649 1994877..1996529 1 NC_003317.1 oligopeptide transport ATP-binding protein OPPD 1996529 1197649 BMEI1938 Brucella melitensis bv. 1 str. 16M oligopeptide transport ATP-binding protein OPPD NP_540855.1 1994877 D 224914 CDS NP_540856.1 17988222 1197650 1996526..1997482 1 NC_003317.1 D-3-phosphoglycerate dehydrogenase 1997482 1197650 BMEI1939 Brucella melitensis bv. 1 str. 16M D-3-phosphoglycerate dehydrogenase NP_540856.1 1996526 D 224914 CDS NP_540857.1 17988223 1197651 complement(1997499..1998308) 1 NC_003317.1 ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase; molybdopterin biosynthesis protein MoeB 1998308 1197651 BMEI1940 Brucella melitensis bv. 1 str. 16M molybdopterin biosynthesis protein MoeB NP_540857.1 1997499 R 224914 CDS NP_540858.1 17988224 1197652 complement(1998319..1999473) 1 NC_003317.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 1999473 recF 1197652 recF Brucella melitensis bv. 1 str. 16M recombination protein F NP_540858.1 1998319 R 224914 CDS NP_540859.1 17988225 1197653 complement(1999655..2000848) 1 NC_003317.1 binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 2000848 1197653 BMEI1942 Brucella melitensis bv. 1 str. 16M DNA polymerase III subunit beta NP_540859.1 1999655 R 224914 CDS NP_540860.1 17988226 1197654 complement(2001077..2002660) 1 NC_003317.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosome replication initiator DnaA 2002660 dnaA 1197654 dnaA Brucella melitensis bv. 1 str. 16M chromosome replication initiator DnaA NP_540860.1 2001077 R 224914 CDS NP_540861.1 17988227 1197655 complement(2003557..2003823) 1 NC_003317.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 2003823 rpsT 1197655 rpsT Brucella melitensis bv. 1 str. 16M 30S ribosomal protein S20 NP_540861.1 2003557 R 224914 CDS NP_540862.2 229220680 1197656 complement(2004160..2004933) 1 NC_003317.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 2004933 1197656 BMEI1945 Brucella melitensis bv. 1 str. 16M enoyl-CoA hydratase NP_540862.2 2004160 R 224914 CDS NP_540863.1 17988229 1197657 complement(2005060..2005941) 1 NC_003317.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 2005941 1197657 BMEI1946 Brucella melitensis bv. 1 str. 16M formamidopyrimidine-DNA glycosylase NP_540863.1 2005060 R 224914 CDS NP_540864.1 17988230 1197658 complement(2006097..2006396) 1 NC_003317.1 hypothetical protein 2006396 1197658 BMEI1947 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540864.1 2006097 R 224914 CDS NP_540865.1 17988231 1197659 2006500..2007882 1 NC_003317.1 cytosol aminopeptidase 2007882 1197659 BMEI1948 Brucella melitensis bv. 1 str. 16M cytosol aminopeptidase NP_540865.1 2006500 D 224914 CDS NP_540866.1 17988232 1197660 2007993..2008307 1 NC_003317.1 MarR family transcriptional regulator 2008307 1197660 BMEI1949 Brucella melitensis bv. 1 str. 16M MarR family transcriptional regulator NP_540866.1 2007993 D 224914 CDS NP_540867.1 17988233 1197661 2008304..2009176 1 NC_003317.1 gamma-D-glutamyl-L-diamino acid endopeptidase II 2009176 1197661 BMEI1950 Brucella melitensis bv. 1 str. 16M gamma-D-glutamyl-L-diamino acid endopeptidase II NP_540867.1 2008304 D 224914 CDS NP_540868.1 17988234 1197662 2009198..2009899 1 NC_003317.1 hydrolase 2009899 1197662 BMEI1951 Brucella melitensis bv. 1 str. 16M hydrolase NP_540868.1 2009198 D 224914 CDS NP_540869.1 17988235 1197663 complement(2009924..2011006) 1 NC_003317.1 Involved in the metabolism of aromatic amino acids; 2-hydroxyacid dehydrogenase 2011006 1197663 BMEI1952 Brucella melitensis bv. 1 str. 16M 2-hydroxyacid dehydrogenase NP_540869.1 2009924 R 224914 CDS NP_540870.1 17988236 1197664 2011321..2011824 1 NC_003317.1 aspartyl-tRNA synthetase 2011824 1197664 BMEI1953 Brucella melitensis bv. 1 str. 16M aspartyl-tRNA synthetase NP_540870.1 2011321 D 224914 CDS NP_540871.1 17988237 1197665 complement(2011869..2012675) 1 NC_003317.1 ABC transporter substrate-binding protein 2012675 1197665 BMEI1954 Brucella melitensis bv. 1 str. 16M ABC transporter substrate-binding protein NP_540871.1 2011869 R 224914 CDS NP_540872.1 17988238 1197666 complement(2012814..2013218) 1 NC_003317.1 ferric uptake regulation protein 2013218 1197666 BMEI1955 Brucella melitensis bv. 1 str. 16M ferric uptake regulation protein NP_540872.1 2012814 R 224914 CDS NP_540873.1 17988239 1197667 2013503..2014021 1 NC_003317.1 catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP; 3-hydroxydecanoyl-ACP dehydratase 2014021 1197667 BMEI1956 Brucella melitensis bv. 1 str. 16M 3-hydroxydecanoyl-ACP dehydratase NP_540873.1 2013503 D 224914 CDS NP_540874.1 17988240 1197668 2014187..2015410 1 NC_003317.1 FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 2015410 1197668 BMEI1957 Brucella melitensis bv. 1 str. 16M 3-oxoacyl-ACP synthase NP_540874.1 2014187 D 224914 CDS NP_540875.1 17988241 1197669 2015425..2016243 1 NC_003317.1 Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-ACP reductase 2016243 1197669 BMEI1958 Brucella melitensis bv. 1 str. 16M enoyl-ACP reductase NP_540875.1 2015425 D 224914 CDS NP_540876.1 17988242 1197670 complement(2016291..2016623) 1 NC_003317.1 methyltransferase 2016623 1197670 BMEI1959 Brucella melitensis bv. 1 str. 16M methyltransferase NP_540876.1 2016291 R 224914 CDS NP_540877.1 17988243 1197671 complement(2016547..2017314) 1 NC_003317.1 methyltransferase 2017314 1197671 BMEI1960 Brucella melitensis bv. 1 str. 16M methyltransferase NP_540877.1 2016547 R 224914 CDS NP_540878.1 17988244 1197672 complement(2017425..2019569) 1 NC_003317.1 polynucleotide phosphorylase 2019569 1197672 BMEI1961 Brucella melitensis bv. 1 str. 16M polynucleotide phosphorylase NP_540878.1 2017425 R 224914 CDS NP_540879.2 161511119 1197673 complement(2019853..2020122) 1 NC_003317.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 2020122 rpsO 1197673 rpsO Brucella melitensis bv. 1 str. 16M 30S ribosomal protein S15 NP_540879.2 2019853 R 224914 CDS NP_540880.1 17988246 1197674 complement(2020293..2021267) 1 NC_003317.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 2021267 truB 1197674 truB Brucella melitensis bv. 1 str. 16M tRNA pseudouridine synthase B NP_540880.1 2020293 R 224914 CDS NP_540881.1 17988247 1197675 complement(2021271..2021786) 1 NC_003317.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 2021786 rbfA 1197675 rbfA Brucella melitensis bv. 1 str. 16M ribosome-binding factor A NP_540881.1 2021271 R 224914 CDS NP_540882.2 161511118 1197676 complement(2021989..2024868) 1 NC_003317.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 2024868 infB 1197676 infB Brucella melitensis bv. 1 str. 16M translation initiation factor IF-2 NP_540882.2 2021989 R 224914 CDS NP_540883.1 17988249 1197677 complement(2025006..2025656) 1 NC_003317.1 hypothetical protein 2025656 1197677 BMEI1966 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540883.1 2025006 R 224914 CDS NP_540884.1 17988250 1197678 complement(2025991..2027604) 1 NC_003317.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 2027604 nusA 1197678 nusA Brucella melitensis bv. 1 str. 16M transcription elongation factor NusA NP_540884.1 2025991 R 224914 CDS NP_540885.1 17988251 1197679 complement(2027657..2028316) 1 NC_003317.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 2028316 1197679 BMEI1968 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540885.1 2027657 R 224914 CDS NP_540886.1 17988252 1197680 complement(2028496..2029197) 1 NC_003317.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 2029197 trmB 1197680 trmB Brucella melitensis bv. 1 str. 16M tRNA (guanine-N(7)-)-methyltransferase NP_540886.1 2028496 R 224914 CDS NP_540887.2 161511117 1197681 complement(2029206..2030471) 1 NC_003317.1 methionine adenosyltransferase; catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 2030471 1197681 BMEI1970 Brucella melitensis bv. 1 str. 16M S-adenosylmethionine synthetase NP_540887.2 2029206 R 224914 CDS NP_540888.1 17988254 1197682 complement(2030698..2031111) 1 NC_003317.1 transcriptional regulator 2031111 1197682 BMEI1971 Brucella melitensis bv. 1 str. 16M transcriptional regulator NP_540888.1 2030698 R 224914 CDS NP_540889.1 17988255 1197683 complement(2031258..2032856) 1 NC_003317.1 Transfers the fatty acyl group on membrane lipoproteins; apolipoprotein N-acyltransferase 2032856 lnt 1197683 lnt Brucella melitensis bv. 1 str. 16M apolipoprotein N-acyltransferase NP_540889.1 2031258 R 224914 CDS NP_540890.1 17988256 1197684 complement(2032853..2033971) 1 NC_003317.1 hypothetical protein 2033971 1197684 BMEI1973 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540890.1 2032853 R 224914 CDS NP_540891.1 17988257 1197685 complement(2033974..2034480) 1 NC_003317.1 diacyglycerol kinase 2034480 1197685 BMEI1974 Brucella melitensis bv. 1 str. 16M diacyglycerol kinase NP_540891.1 2033974 R 224914 CDS NP_540892.1 17988258 1197686 complement(2034616..2035563) 1 NC_003317.1 PhoH protein 2035563 1197686 BMEI1975 Brucella melitensis bv. 1 str. 16M PhoH protein NP_540892.1 2034616 R 224914 CDS NP_540893.1 17988259 1197687 complement(2035837..2037240) 1 NC_003317.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase 2037240 1197687 BMEI1976 Brucella melitensis bv. 1 str. 16M (dimethylallyl)adenosine tRNA methylthiotransferase NP_540893.1 2035837 R 224914 CDS NP_540894.1 17988260 1197688 complement(2037298..2038101) 1 NC_003317.1 1-acyl-SN-glycerol-3-phosphate acyltransferase 2038101 1197688 BMEI1977 Brucella melitensis bv. 1 str. 16M 1-acyl-SN-glycerol-3-phosphate acyltransferase NP_540894.1 2037298 R 224914 CDS NP_540895.1 17988261 1197689 complement(2038098..2038640) 1 NC_003317.1 ribosomal-protein-alanine acetyltransferase 2038640 1197689 BMEI1978 Brucella melitensis bv. 1 str. 16M ribosomal-protein-alanine acetyltransferase NP_540895.1 2038098 R 224914 CDS NP_540896.1 17988262 1197690 complement(2038603..2039388) 1 NC_003317.1 O-sialoglycoprotein endopeptidase 2039388 1197690 BMEI1979 Brucella melitensis bv. 1 str. 16M O-sialoglycoprotein endopeptidase NP_540896.1 2038603 R 224914 CDS NP_540897.2 161511116 1197691 2039575..2040072 1 NC_003317.1 binds DNA in a non-sequence-specific manner and is abundant during stationary phase; forms a DNA-protein crystal that protects DNA from damage; required for normal starvation response and long-term stationary viability; forms a homododecameric complex and sequesters iron which provides protection against oxidative damage; DNA starvation/stationary phase protection protein Dps 2040072 1197691 BMEI1980 Brucella melitensis bv. 1 str. 16M DNA starvation/stationary phase protection protein Dps NP_540897.2 2039575 D 224914 CDS NP_540898.1 17988264 1197692 complement(2040233..2041516) 1 NC_003317.1 aminopeptidase 2041516 1197692 BMEI1981 Brucella melitensis bv. 1 str. 16M aminopeptidase NP_540898.1 2040233 R 224914 CDS NP_540899.1 17988265 1197693 2041563..2041886 1 NC_003317.1 hypothetical protein 2041886 1197693 BMEI1982 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540899.1 2041563 D 224914 CDS NP_540900.1 17988266 1197694 complement(2041996..2042913) 1 NC_003317.1 spore-cortex-lytic enzyme prepeptide 2042913 1197694 BMEI1983 Brucella melitensis bv. 1 str. 16M spore-cortex-lytic enzyme prepeptide NP_540900.1 2041996 R 224914 CDS NP_540901.1 17988267 1197695 complement(2043562..2044329) 1 NC_003317.1 phosphate regulon transcriptional regulatory protein PHOB 2044329 1197695 BMEI1984 Brucella melitensis bv. 1 str. 16M phosphate regulon transcriptional regulatory protein PHOB NP_540901.1 2043562 R 224914 CDS NP_540902.1 17988268 1197696 complement(2044366..2045088) 1 NC_003317.1 phosphate transporter PhoU 2045088 1197696 BMEI1985 Brucella melitensis bv. 1 str. 16M phosphate transporter PhoU NP_540902.1 2044366 R 224914 CDS NP_540903.1 17988269 1197697 complement(2045154..2046035) 1 NC_003317.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 2046035 1197697 BMEI1986 Brucella melitensis bv. 1 str. 16M phosphate transporter ATP-binding protein NP_540903.1 2045154 R 224914 CDS NP_540904.1 17988270 1197698 complement(2045992..2047302) 1 NC_003317.1 phosphate ABC transporter permease 2047302 1197698 BMEI1987 Brucella melitensis bv. 1 str. 16M phosphate ABC transporter permease NP_540904.1 2045992 R 224914 CDS NP_540905.1 17988271 1197699 complement(2047302..2048792) 1 NC_003317.1 phosphate ABC transporter permease 2048792 1197699 BMEI1988 Brucella melitensis bv. 1 str. 16M phosphate ABC transporter permease NP_540905.1 2047302 R 224914 CDS NP_540906.1 17988272 1197700 complement(2048934..2049971) 1 NC_003317.1 phosphate-binding periplasmic protein 2049971 1197700 BMEI1989 Brucella melitensis bv. 1 str. 16M phosphate-binding periplasmic protein NP_540906.1 2048934 R 224914 CDS NP_540907.1 17988273 1197701 complement(2050135..2050575) 1 NC_003317.1 hypothetical protein 2050575 1197701 BMEI1990 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540907.1 2050135 R 224914 CDS NP_540908.1 17988274 1197702 complement(2050718..2050936) 1 NC_003317.1 hypothetical protein 2050936 1197702 BMEI1991 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540908.1 2050718 R 224914 CDS NP_540909.1 17988275 1197703 2051119..2051451 1 NC_003317.1 rare lipoprotein A 2051451 1197703 BMEI1992 Brucella melitensis bv. 1 str. 16M rare lipoprotein A NP_540909.1 2051119 D 224914 CDS NP_540910.1 17988276 1197704 2051965..2052519 1 NC_003317.1 hypothetical protein 2052519 1197704 BMEI1993 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540910.1 2051965 D 224914 CDS NP_540911.1 17988277 1197705 complement(2052568..2053587) 1 NC_003317.1 Mg(2+) chelatase family protein 2053587 1197705 BMEI1994 Brucella melitensis bv. 1 str. 16M Mg(2+) chelatase family protein NP_540911.1 2052568 R 224914 CDS NP_540912.1 17988278 1197706 complement(2053678..2054133) 1 NC_003317.1 Mg(2+) chelatase family protein 2054133 1197706 BMEI1995 Brucella melitensis bv. 1 str. 16M Mg(2+) chelatase family protein NP_540912.1 2053678 R 224914 CDS NP_540913.1 17988279 1197707 complement(2054210..2055148) 1 NC_003317.1 catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione; glutathione synthetase 2055148 1197707 BMEI1996 Brucella melitensis bv. 1 str. 16M glutathione synthetase NP_540913.1 2054210 R 224914 CDS NP_540914.1 17988280 1197708 2055396..2056271 1 NC_003317.1 gluconolactonase 2056271 1197708 BMEI1997 Brucella melitensis bv. 1 str. 16M gluconolactonase NP_540914.1 2055396 D 224914 CDS NP_540915.1 17988281 1197709 complement(2056309..2056596) 1 NC_003317.1 hypothetical protein 2056596 1197709 BMEI1998 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540915.1 2056309 R 224914 CDS NP_540916.1 17988282 1197710 complement(2056645..2057424) 1 NC_003317.1 OMP decarboxylase; OMPDCase; OMPdecase; type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 2057424 1197710 BMEI1999 Brucella melitensis bv. 1 str. 16M orotidine 5'-phosphate decarboxylase NP_540916.1 2056645 R 224914 CDS NP_540917.1 17988283 1197711 complement(2057571..2058170) 1 NC_003317.1 phosphatidylethanolamine N-methyltransferase/phosphatidyl-N-methylethanolamine N-methyltransferase 2058170 1197711 BMEI2000 Brucella melitensis bv. 1 str. 16M phosphatidylethanolamine N-methyltransferase/phosphatidyl-N-methylethanolamine N-methyltransferase NP_540917.1 2057571 R 224914 CDS NP_540918.1 17988284 1197712 complement(2058291..2059424) 1 NC_003317.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; molecular chaperone DnaJ 2059424 1197712 BMEI2001 Brucella melitensis bv. 1 str. 16M molecular chaperone DnaJ NP_540918.1 2058291 R 224914 CDS NP_540919.1 17988285 1197713 complement(2059670..2061595) 1 NC_003317.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 2061595 dnaK 1197713 dnaK Brucella melitensis bv. 1 str. 16M molecular chaperone DnaK NP_540919.1 2059670 R 224914 CDS NP_540920.1 17988286 1197714 complement(2061809..2062828) 1 NC_003317.1 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase / D-xylose 1-dehydrogenase (NADP+) 2062828 1197714 BMEI2003 Brucella melitensis bv. 1 str. 16M trans-1,2-dihydrobenzene-1,2-diol dehydrogenase / D-xylose 1-dehydrogenase (NADP+) NP_540920.1 2061809 R 224914 CDS NP_540921.1 17988287 1197715 complement(2062865..2065279) 1 NC_003317.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 2065279 pheT 1197715 pheT Brucella melitensis bv. 1 str. 16M phenylalanyl-tRNA synthetase subunit beta NP_540921.1 2062865 R 224914 CDS NP_540922.1 17988288 1197716 complement(2065301..2066410) 1 NC_003317.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 2066410 pheS 1197716 pheS Brucella melitensis bv. 1 str. 16M phenylalanyl-tRNA synthetase subunit alpha NP_540922.1 2065301 R 224914 CDS NP_540923.1 17988289 1197717 complement(2066538..2067353) 1 NC_003317.1 hypothetical protein 2067353 1197717 BMEI2006 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540923.1 2066538 R 224914 CDS NP_540924.1 17988290 1197718 complement(2067479..2067883) 1 NC_003317.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 2067883 rplT 1197718 rplT Brucella melitensis bv. 1 str. 16M 50S ribosomal protein L20 NP_540924.1 2067479 R 224914 CDS NP_540925.1 17988291 1197719 complement(2067911..2068111) 1 NC_003317.1 50S ribosomal protein L35 2068111 rpmI 1197719 rpmI Brucella melitensis bv. 1 str. 16M 50S ribosomal protein L35 NP_540925.1 2067911 R 224914 CDS NP_540926.1 17988292 1197720 complement(2068378..2068899) 1 NC_003317.1 nickel-cobalt-cadmium resistance protein NCCN 2068899 1197720 BMEI2009 Brucella melitensis bv. 1 str. 16M nickel-cobalt-cadmium resistance protein NCCN NP_540926.1 2068378 R 224914 CDS NP_540927.1 17988293 1197721 complement(2069121..2069525) 1 NC_003317.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 2069525 infC 1197721 infC Brucella melitensis bv. 1 str. 16M translation initiation factor IF-3 NP_540927.1 2069121 R 224914 CDS NP_540928.1 17988294 1197722 2069957..2070748 1 NC_003317.1 2-hydroxymuconic semialdehyde hydrolase 2070748 1197722 BMEI2011 Brucella melitensis bv. 1 str. 16M 2-hydroxymuconic semialdehyde hydrolase NP_540928.1 2069957 D 224914 CDS NP_540929.1 17988295 1197723 2070762..2071913 1 NC_003317.1 benzoate membrane transport protein 2071913 1197723 BMEI2012 Brucella melitensis bv. 1 str. 16M benzoate membrane transport protein NP_540929.1 2070762 D 224914 CDS NP_540930.1 17988296 1197724 2072110..2072283 1 NC_003317.1 hypothetical protein 2072283 1197724 BMEI2013 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540930.1 2072110 D 224914 CDS NP_540931.1 17988297 1197725 2072243..2072542 1 NC_003317.1 hypothetical protein 2072542 1197725 BMEI2014 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540931.1 2072243 D 224914 CDS NP_540932.1 17988298 1197726 2072651..2073412 1 NC_003317.1 zinc metallopeptidase 2073412 1197726 BMEI2015 Brucella melitensis bv. 1 str. 16M zinc metallopeptidase NP_540932.1 2072651 D 224914 CDS NP_540933.1 17988299 1197727 2073409..2074044 1 NC_003317.1 hypothetical protein 2074044 1197727 BMEI2016 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540933.1 2073409 D 224914 CDS NP_540934.1 17988300 1197728 2074068..2074751 1 NC_003317.1 catalyzes the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)-anthranilate in tryptophan biosynthesis; N-(5'-phosphoribosyl)anthranilate isomerase 2074751 1197728 BMEI2017 Brucella melitensis bv. 1 str. 16M N-(5'-phosphoribosyl)anthranilate isomerase NP_540934.1 2074068 D 224914 CDS NP_540935.1 17988301 1197729 2074723..2075991 1 NC_003317.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 2075991 1197729 BMEI2018 Brucella melitensis bv. 1 str. 16M tryptophan synthase subunit beta NP_540935.1 2074723 D 224914 CDS NP_540936.1 17988302 1197730 2076386..2077297 1 NC_003317.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 2077297 trpA 1197730 trpA Brucella melitensis bv. 1 str. 16M tryptophan synthase subunit alpha NP_540936.1 2076386 D 224914 CDS NP_540937.1 17988303 1197731 2077358..2078263 1 NC_003317.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta 2078263 1197731 BMEI2020 Brucella melitensis bv. 1 str. 16M acetyl-CoA carboxylase subunit beta NP_540937.1 2077358 D 224914 CDS NP_540938.1 17988304 1197732 2078266..2079594 1 NC_003317.1 folylpolyglutamate synthase / dihydrofolate synthase 2079594 1197732 BMEI2021 Brucella melitensis bv. 1 str. 16M folylpolyglutamate synthase / dihydrofolate synthase NP_540938.1 2078266 D 224914 CDS NP_540939.1 17988305 1197733 complement(2079808..2080131) 1 NC_003317.1 thioredoxin 2080131 1197733 BMEI2022 Brucella melitensis bv. 1 str. 16M thioredoxin NP_540939.1 2079808 R 224914 CDS NP_540940.1 17988306 1197734 complement(2080313..2083855) 1 NC_003317.1 ATP-dependent nuclease subunit A 2083855 1197734 BMEI2023 Brucella melitensis bv. 1 str. 16M ATP-dependent nuclease subunit A NP_540940.1 2080313 R 224914 CDS NP_540941.1 17988307 1197735 complement(2083852..2087010) 1 NC_003317.1 hypothetical protein 2087010 1197735 BMEI2024 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540941.1 2083852 R 224914 CDS NP_540942.1 17988308 1197736 complement(2087025..2087744) 1 NC_003317.1 mannose-1-phosphate guanylyltransferase 2087744 1197736 BMEI2025 Brucella melitensis bv. 1 str. 16M mannose-1-phosphate guanylyltransferase NP_540942.1 2087025 R 224914 CDS NP_540943.1 17988309 1197737 complement(2087731..2089272) 1 NC_003317.1 7.5 kDa chlorosome protein 2089272 1197737 BMEI2026 Brucella melitensis bv. 1 str. 16M 7.5 kDa chlorosome protein NP_540943.1 2087731 R 224914 CDS NP_540944.1 17988310 1197738 complement(2089281..2091587) 1 NC_003317.1 alkaline phosphatase synthesis sensor protein phoR 2091587 1197738 BMEI2027 Brucella melitensis bv. 1 str. 16M alkaline phosphatase synthesis sensor protein phoR NP_540944.1 2089281 R 224914 CDS NP_540945.1 17988311 1197739 complement(2091848..2092057) 1 NC_003317.1 hypothetical protein 2092057 1197739 BMEI2028 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540945.1 2091848 R 224914 CDS NP_540946.1 17988312 1197740 complement(2092245..2093690) 1 NC_003317.1 catalyzes the formation of L-homocysteine from S-adenosyl-L-homocysteine; S-adenosyl-L-homocysteine hydrolase 2093690 1197740 BMEI2029 Brucella melitensis bv. 1 str. 16M S-adenosyl-L-homocysteine hydrolase NP_540946.1 2092245 R 224914 CDS NP_540947.1 17988313 1197741 complement(2093642..2093959) 1 NC_003317.1 hypothetical protein 2093959 1197741 BMEI2030 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540947.1 2093642 R 224914 CDS NP_540948.1 17988314 1197742 complement(2094023..2094325) 1 NC_003317.1 phosphocarrier protein HPr 2094325 1197742 BMEI2031 Brucella melitensis bv. 1 str. 16M phosphocarrier protein HPr NP_540948.1 2094023 R 224914 CDS NP_540949.1 17988315 1197743 complement(2094341..2094775) 1 NC_003317.1 PTS system transporter subunit IIA 2094775 1197743 BMEI2032 Brucella melitensis bv. 1 str. 16M PTS system transporter subunit IIA NP_540949.1 2094341 R 224914 CDS NP_540950.1 17988316 1197744 complement(2094744..2095019) 1 NC_003317.1 hypothetical protein 2095019 1197744 BMEI2033 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540950.1 2094744 R 224914 CDS NP_540951.1 17988317 1197745 complement(2094994..2095473) 1 NC_003317.1 sensor protein CHVG 2095473 1197745 BMEI2034 Brucella melitensis bv. 1 str. 16M sensor protein CHVG NP_540951.1 2094994 R 224914 CDS NP_540952.1 17988318 1197746 complement(2095499..2097304) 1 NC_003317.1 sensor protein CHVG 2097304 1197746 BMEI2035 Brucella melitensis bv. 1 str. 16M sensor protein CHVG NP_540952.1 2095499 R 224914 CDS NP_540953.1 17988319 1197747 complement(2097415..2098134) 1 NC_003317.1 transcriptional regulatory protein chvI 2098134 1197747 BMEI2036 Brucella melitensis bv. 1 str. 16M transcriptional regulatory protein chvI NP_540953.1 2097415 R 224914 CDS NP_540954.1 17988320 1197748 2098536..2100011 1 NC_003317.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP; phosphoenolpyruvate carboxykinase 2100011 1197748 BMEI2037 Brucella melitensis bv. 1 str. 16M phosphoenolpyruvate carboxykinase NP_540954.1 2098536 D 224914 CDS NP_540955.1 17988321 1197749 2100257..2100694 1 NC_003317.1 peptidyl-tRNA hydrolase domain-containing protein 2100694 1197749 BMEI2038 Brucella melitensis bv. 1 str. 16M peptidyl-tRNA hydrolase domain-containing protein NP_540955.1 2100257 D 224914 CDS NP_540956.1 17988322 1197750 complement(2100757..2101725) 1 NC_003317.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase 2101725 1197750 BMEI2039 Brucella melitensis bv. 1 str. 16M pantothenate kinase NP_540956.1 2100757 R 224914 CDS NP_540957.2 161511115 1197751 complement(2101740..2102063) 1 NC_003317.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis; phosphoribosyl-ATP pyrophosphatase 2102063 hisE 1197751 hisE Brucella melitensis bv. 1 str. 16M phosphoribosyl-ATP pyrophosphatase NP_540957.2 2101740 R 224914 CDS NP_540958.1 17988324 1197752 complement(2102199..2102984) 1 NC_003317.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF 2102984 1197752 BMEI2041 Brucella melitensis bv. 1 str. 16M imidazole glycerol phosphate synthase subunit HisF NP_540958.1 2102199 R 224914 CDS NP_540959.1 17988325 1197753 complement(2102981..2103712) 1 NC_003317.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 2103712 1197753 BMEI2042 Brucella melitensis bv. 1 str. 16M 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase NP_540959.1 2102981 R 224914 CDS NP_540960.2 161511114 1197754 complement(2103717..2104367) 1 NC_003317.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 2104367 hisH 1197754 hisH Brucella melitensis bv. 1 str. 16M imidazole glycerol phosphate synthase subunit HisH NP_540960.2 2103717 R 224914 CDS NP_540961.1 17988327 1197755 complement(2104370..2104879) 1 NC_003317.1 hypothetical protein 2104879 1197755 BMEI2044 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540961.1 2104370 R 224914 CDS NP_540962.1 17988328 1197756 complement(2104991..2105599) 1 NC_003317.1 catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis; imidazoleglycerol-phosphate dehydratase 2105599 hisB 1197756 hisB Brucella melitensis bv. 1 str. 16M imidazoleglycerol-phosphate dehydratase NP_540962.1 2104991 R 224914 CDS NP_540963.1 17988329 1197757 2105583..2105864 1 NC_003317.1 hypothetical protein 2105864 1197757 BMEI2046 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540963.1 2105583 D 224914 CDS NP_540964.1 17988330 1197758 2105896..2106450 1 NC_003317.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit 2106450 1197758 BMEI2047 Brucella melitensis bv. 1 str. 16M ATP-dependent protease peptidase subunit NP_540964.1 2105896 D 224914 CDS NP_540965.1 17988331 1197759 2106524..2107828 1 NC_003317.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease ATP-binding subunit HslU 2107828 hslU 1197759 hslU Brucella melitensis bv. 1 str. 16M ATP-dependent protease ATP-binding subunit HslU NP_540965.1 2106524 D 224914 CDS NP_540966.1 17988332 1197760 2108065..2108994 1 NC_003317.1 hypothetical protein 2108994 1197760 BMEI2049 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540966.1 2108065 D 224914 CDS NP_540967.1 17988333 1197761 complement(2109003..2109383) 1 NC_003317.1 transcriptional regulator 2109383 1197761 BMEI2050 Brucella melitensis bv. 1 str. 16M transcriptional regulator NP_540967.1 2109003 R 224914 CDS NP_540968.1 17988334 1197762 complement(2109380..2109913) 1 NC_003317.1 SMR/MUTS family protein 2109913 1197762 BMEI2051 Brucella melitensis bv. 1 str. 16M SMR/MUTS family protein NP_540968.1 2109380 R 224914 CDS NP_540969.1 17988335 1197763 complement(2109989..2111098) 1 NC_003317.1 membrane-bound lytic murein transglycosylase A 2111098 1197763 BMEI2052 Brucella melitensis bv. 1 str. 16M membrane-bound lytic murein transglycosylase A NP_540969.1 2109989 R 224914 CDS NP_540970.1 17988336 1197764 complement(2111162..2111812) 1 NC_003317.1 transporter 2111812 1197764 BMEI2053 Brucella melitensis bv. 1 str. 16M transporter NP_540970.1 2111162 R 224914 CDS NP_540971.1 17988337 1197765 2112074..2112571 1 NC_003317.1 F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein; FxsA protein 2112571 fxsA 1197765 fxsA Brucella melitensis bv. 1 str. 16M FxsA protein NP_540971.1 2112074 D 224914 CDS NP_540972.1 17988338 1197766 2112691..2113182 1 NC_003317.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB 2113182 1197766 BMEI2055 Brucella melitensis bv. 1 str. 16M preprotein translocase subunit SecB NP_540972.1 2112691 D 224914 CDS NP_540973.1 17988339 1197767 complement(2113241..2113987) 1 NC_003317.1 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 2113987 1197767 BMEI2056 Brucella melitensis bv. 1 str. 16M DNA polymerase III subunit epsilon NP_540973.1 2113241 R 224914 CDS NP_540974.1 17988340 1197768 complement(2113987..2114589) 1 NC_003317.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 2114589 coaE 1197768 coaE Brucella melitensis bv. 1 str. 16M dephospho-CoA kinase NP_540974.1 2113987 R 224914 CDS NP_540975.1 17988341 1197769 complement(2114586..2115455) 1 NC_003317.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 2115455 aroE 1197769 aroE Brucella melitensis bv. 1 str. 16M shikimate 5-dehydrogenase NP_540975.1 2114586 R 224914 CDS NP_540976.1 17988342 1197770 complement(2115448..2116047) 1 NC_003317.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 2116047 maf 1197770 maf Brucella melitensis bv. 1 str. 16M Maf-like protein NP_540976.1 2115448 R 224914 CDS NP_540977.1 17988343 1197771 complement(2116044..2116943) 1 NC_003317.1 hypothetical protein 2116943 1197771 BMEI2060 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540977.1 2116044 R 224914 CDS NP_540978.1 17988345 1197772 complement(120..329) 1 NC_003318.1 hypothetical protein 329 1197772 BMEII0001 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540978.1 120 R 224914 CDS NP_540979.1 17988346 1197773 complement(316..1044) 1 NC_003318.1 ribosomal-protein-serine acetyltransferase 1044 1197773 BMEII0002 Brucella melitensis bv. 1 str. 16M ribosomal-protein-serine acetyltransferase NP_540979.1 316 R 224914 CDS NP_540980.1 17988347 1197774 complement(1063..2175) 1 NC_003318.1 molybdenum ABC transporter ATP-binding protein 2175 1197774 BMEII0003 Brucella melitensis bv. 1 str. 16M molybdenum ABC transporter ATP-binding protein NP_540980.1 1063 R 224914 CDS NP_540981.1 17988348 1197775 complement(2139..2825) 1 NC_003318.1 part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE; molybdate ABC transporter permease 2825 modB 1197775 modB Brucella melitensis bv. 1 str. 16M molybdate ABC transporter permease NP_540981.1 2139 R 224914 CDS NP_540982.1 17988349 1197776 complement(2836..3537) 1 NC_003318.1 molybdate-binding periplasmic protein 3537 1197776 BMEII0005 Brucella melitensis bv. 1 str. 16M molybdate-binding periplasmic protein NP_540982.1 2836 R 224914 CDS NP_540983.1 17988350 1197777 complement(3631..3837) 1 NC_003318.1 hypothetical protein 3837 1197777 BMEII0006 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540983.1 3631 R 224914 CDS NP_540984.1 17988351 1197778 complement(3872..4789) 1 NC_003318.1 rhodanese-related sulfurtransferase 4789 1197778 BMEII0007 Brucella melitensis bv. 1 str. 16M rhodanese-related sulfurtransferase NP_540984.1 3872 R 224914 CDS NP_540985.1 17988352 1197779 4974..5498 1 NC_003318.1 hypothetical protein 5498 1197779 BMEII0008 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540985.1 4974 D 224914 CDS NP_540986.1 17988353 1197780 5612..6295 1 NC_003318.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase 6295 1197780 BMEII0009 Brucella melitensis bv. 1 str. 16M keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase NP_540986.1 5612 D 224914 CDS NP_540987.1 17988354 1197781 complement(6361..8274) 1 NC_003318.1 hypothetical protein 8274 1197781 BMEII0010 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540987.1 6361 R 224914 CDS NP_540988.1 17988355 1197782 complement(8615..10105) 1 NC_003318.1 transcriptional regulatory protein hydG 10105 1197782 BMEII0011 Brucella melitensis bv. 1 str. 16M transcriptional regulatory protein hydG NP_540988.1 8615 R 224914 CDS NP_540989.1 17988356 1197783 10492..12315 1 NC_003318.1 oligoendopeptidase F 12315 1197783 BMEII0012 Brucella melitensis bv. 1 str. 16M oligoendopeptidase F NP_540989.1 10492 D 224914 CDS NP_540990.1 17988357 1197784 12325..13494 1 NC_003318.1 catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine; aminodeoxychorismate synthase 13494 1197784 BMEII0013 Brucella melitensis bv. 1 str. 16M aminodeoxychorismate synthase NP_540990.1 12325 D 224914 CDS NP_540991.1 17988358 1197785 13278..14108 1 NC_003318.1 hypothetical protein 14108 1197785 BMEII0014 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540991.1 13278 D 224914 CDS NP_540992.1 17988359 1197786 14220..14981 1 NC_003318.1 homospermidine synthase 14981 1197786 BMEII0015 Brucella melitensis bv. 1 str. 16M homospermidine synthase NP_540992.1 14220 D 224914 CDS NP_540993.1 17988360 1197787 14863..15666 1 NC_003318.1 homospermidine synthase 15666 1197787 BMEII0016 Brucella melitensis bv. 1 str. 16M homospermidine synthase NP_540993.1 14863 D 224914 CDS NP_540994.1 17988361 1197788 15808..16188 1 NC_003318.1 outer membrane lipoprotein 16188 1197788 BMEII0017 Brucella melitensis bv. 1 str. 16M outer membrane lipoprotein NP_540994.1 15808 D 224914 CDS NP_540995.1 17988362 1197789 16326..17384 1 NC_003318.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 17384 hemH 1197789 hemH Brucella melitensis bv. 1 str. 16M ferrochelatase NP_540995.1 16326 D 224914 CDS NP_540996.1 17988363 1197790 17517..18503 1 NC_003318.1 stomatin like protein 18503 1197790 BMEII0019 Brucella melitensis bv. 1 str. 16M stomatin like protein NP_540996.1 17517 D 224914 CDS NP_540997.1 17988364 1197791 18524..18991 1 NC_003318.1 nodulation protein NFED, C-terminal only 18991 1197791 BMEII0020 Brucella melitensis bv. 1 str. 16M nodulation protein NFED, C-terminal only NP_540997.1 18524 D 224914 CDS NP_540998.1 17988365 1197792 complement(19082..20161) 1 NC_003318.1 polysialic acid capsule expression protein KPSF 20161 1197792 BMEII0021 Brucella melitensis bv. 1 str. 16M polysialic acid capsule expression protein KPSF NP_540998.1 19082 R 224914 CDS NP_540999.1 17988366 1197793 20563..21762 1 NC_003318.1 hypothetical protein 21762 1197793 BMEII0022 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_540999.1 20563 D 224914 CDS NP_541000.1 17988367 1197794 complement(21815..22708) 1 NC_003318.1 UTP-glucose-1-phosphate uridylyltransferase 22708 1197794 BMEII0023 Brucella melitensis bv. 1 str. 16M UTP-glucose-1-phosphate uridylyltransferase NP_541000.1 21815 R 224914 CDS NP_541001.1 17988368 1197795 23120..24358 1 NC_003318.1 membrane-bound lytic murein transglycosylase B 24358 1197795 BMEII0024 Brucella melitensis bv. 1 str. 16M membrane-bound lytic murein transglycosylase B NP_541001.1 23120 D 224914 CDS NP_541002.1 17988369 1197796 24862..25578 1 NC_003318.1 attachment mediating protein VIRB1-like protein 25578 1197796 BMEII0025 Brucella melitensis bv. 1 str. 16M attachment mediating protein VIRB1-like protein NP_541002.1 24862 D 224914 CDS NP_541003.1 17988370 1197797 26014..26331 1 NC_003318.1 VirB2 26331 1197797 BMEII0026 Brucella melitensis bv. 1 str. 16M VirB2 NP_541003.1 26014 D 224914 CDS NP_541004.1 17988371 1197798 26345..26695 1 NC_003318.1 VirB3 26695 1197798 BMEII0027 Brucella melitensis bv. 1 str. 16M VirB3 NP_541004.1 26345 D 224914 CDS NP_541005.1 17988372 1197799 26695..29190 1 NC_003318.1 ATPase VIRB4-like protein 29190 1197799 BMEII0028 Brucella melitensis bv. 1 str. 16M ATPase VIRB4-like protein NP_541005.1 26695 D 224914 CDS NP_541006.1 17988373 1197800 29195..29911 1 NC_003318.1 VirB5 29911 1197800 BMEII0029 Brucella melitensis bv. 1 str. 16M VirB5 NP_541006.1 29195 D 224914 CDS NP_541007.1 17988374 1197801 30095..31138 1 NC_003318.1 channel protein VIRB6-like protein 31138 1197801 BMEII0030 Brucella melitensis bv. 1 str. 16M channel protein VIRB6-like protein NP_541007.1 30095 D 224914 CDS NP_541008.1 17988375 1197802 31302..31475 1 NC_003318.1 VirB7 31475 1197802 BMEII0031 Brucella melitensis bv. 1 str. 16M VirB7 NP_541008.1 31302 D 224914 CDS NP_541009.1 17988376 1197803 31478..32197 1 NC_003318.1 VirB8 32197 1197803 BMEII0032 Brucella melitensis bv. 1 str. 16M VirB8 NP_541009.1 31478 D 224914 CDS NP_541010.1 17988377 1197804 32321..33064 1 NC_003318.1 channel protein VIRB9-like protein 33064 1197804 BMEII0033 Brucella melitensis bv. 1 str. 16M channel protein VIRB9-like protein NP_541010.1 32321 D 224914 CDS NP_541011.1 17988378 1197805 33406..34203 1 NC_003318.1 channel protein VIRB10-like protein 34203 1197805 BMEII0034 Brucella melitensis bv. 1 str. 16M channel protein VIRB10-like protein NP_541011.1 33406 D 224914 CDS NP_541012.1 17988379 1197806 34187..35272 1 NC_003318.1 ATPase VIRB11-like protein 35272 1197806 BMEII0035 Brucella melitensis bv. 1 str. 16M ATPase VIRB11-like protein NP_541012.1 34187 D 224914 CDS NP_541013.1 17988380 1197807 35418..35936 1 NC_003318.1 outer membrane protein OprF 35936 1197807 BMEII0036 Brucella melitensis bv. 1 str. 16M outer membrane protein OprF NP_541013.1 35418 D 224914 CDS NP_541014.1 17988381 1197808 36376..37347 1 NC_003318.1 cytoplasmic protein 37347 1197808 BMEII0037 Brucella melitensis bv. 1 str. 16M cytoplasmic protein NP_541014.1 36376 D 224914 CDS NP_541015.1 17988382 1197809 37467..38960 1 NC_003318.1 D-serine/D-alanine/glycine transporter 38960 1197809 BMEII0038 Brucella melitensis bv. 1 str. 16M D-serine/D-alanine/glycine transporter NP_541015.1 37467 D 224914 CDS NP_541016.2 161511181 1197810 complement(39005..40459) 1 NC_003318.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; glutamate synthase subunit beta 40459 gltD 1197810 gltD Brucella melitensis bv. 1 str. 16M glutamate synthase subunit beta NP_541016.2 39005 R 224914 CDS NP_541017.1 17988384 1197811 complement(40541..45262) 1 NC_003318.1 glutamate synthase [NADPH] large chain 45262 1197811 BMEII0040 Brucella melitensis bv. 1 str. 16M glutamate synthase [NADPH] large chain NP_541017.1 40541 R 224914 CDS NP_541018.1 17988385 1197812 45935..46984 1 NC_003318.1 low-specificity threonine aldolase 46984 1197812 BMEII0041 Brucella melitensis bv. 1 str. 16M low-specificity threonine aldolase NP_541018.1 45935 D 224914 CDS NP_541019.1 17988386 1197813 complement(47122..47592) 1 NC_003318.1 HEAT shock protein A 47592 1197813 BMEII0042 Brucella melitensis bv. 1 str. 16M HEAT shock protein A NP_541019.1 47122 R 224914 CDS NP_541020.1 17988387 1197814 complement(47671..47922) 1 NC_003318.1 hypothetical protein 47922 1197814 BMEII0043 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541020.1 47671 R 224914 CDS NP_541021.1 17988388 1197815 complement(47895..48317) 1 NC_003318.1 hypothetical protein 48317 1197815 BMEII0044 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541021.1 47895 R 224914 CDS NP_541022.1 17988389 1197816 48282..48554 1 NC_003318.1 hypothetical protein 48554 1197816 BMEII0045 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541022.1 48282 D 224914 CDS NP_541023.1 17988390 1197817 48649..48864 1 NC_003318.1 hypothetical protein 48864 1197817 BMEII0046 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541023.1 48649 D 224914 CDS NP_541024.1 17988391 1197818 48904..49899 1 NC_003318.1 lysophospholipase L2 49899 1197818 BMEII0047 Brucella melitensis bv. 1 str. 16M lysophospholipase L2 NP_541024.1 48904 D 224914 CDS NP_541025.1 17988392 1197819 complement(49950..50768) 1 NC_003318.1 extragenic suppressor protein SUHB 50768 1197819 BMEII0048 Brucella melitensis bv. 1 str. 16M extragenic suppressor protein SUHB NP_541025.1 49950 R 224914 CDS NP_541026.1 17988393 1197820 complement(50879..51769) 1 NC_003318.1 N-formylglutamate deformylase 51769 1197820 BMEII0049 Brucella melitensis bv. 1 str. 16M N-formylglutamate deformylase NP_541026.1 50879 R 224914 CDS NP_541027.1 17988394 1197821 52088..52450 1 NC_003318.1 sensory transduction histidine kinase 52450 1197821 BMEII0050 Brucella melitensis bv. 1 str. 16M sensory transduction histidine kinase NP_541027.1 52088 D 224914 CDS NP_541028.1 17988395 1197822 complement(52836..53474) 1 NC_003318.1 nodulation protein W 53474 1197822 BMEII0051 Brucella melitensis bv. 1 str. 16M nodulation protein W NP_541028.1 52836 R 224914 CDS NP_541029.1 17988396 1197823 complement(53471..54538) 1 NC_003318.1 sensory transduction histidine kinase 54538 1197823 BMEII0052 Brucella melitensis bv. 1 str. 16M sensory transduction histidine kinase NP_541029.1 53471 R 224914 CDS NP_541030.1 17988397 1197824 complement(54616..55356) 1 NC_003318.1 magnesium ABC transporter ATPase 55356 1197824 BMEII0053 Brucella melitensis bv. 1 str. 16M magnesium ABC transporter ATPase NP_541030.1 54616 R 224914 CDS NP_541031.1 17988398 1197825 complement(55334..55489) 1 NC_003318.1 hypothetical protein 55489 1197825 BMEII0054 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541031.1 55334 R 224914 CDS NP_541032.1 17988399 1197826 complement(55668..56018) 1 NC_003318.1 hypothetical protein 56018 1197826 BMEII0055 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541032.1 55668 R 224914 CDS NP_541033.1 17988400 1197827 complement(56103..58889) 1 NC_003318.1 magnesium ABC transporter ATPase 58889 1197827 BMEII0056 Brucella melitensis bv. 1 str. 16M magnesium ABC transporter ATPase NP_541033.1 56103 R 224914 CDS NP_541034.1 17988401 1197828 58938..59219 1 NC_003318.1 hypothetical protein 59219 1197828 BMEII0057 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541034.1 58938 D 224914 CDS NP_541035.1 17988402 1197829 complement(59173..59466) 1 NC_003318.1 hypothetical protein 59466 1197829 BMEII0058 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541035.1 59173 R 224914 CDS NP_541036.1 17988403 1197830 complement(59746..60531) 1 NC_003318.1 aminoquinate/shkimate dehydrogenase 60531 1197830 BMEII0059 Brucella melitensis bv. 1 str. 16M aminoquinate/shkimate dehydrogenase NP_541036.1 59746 R 224914 CDS NP_541037.1 17988404 1197831 complement(60632..61897) 1 NC_003318.1 branched-chain alpha-keto acid dehydrogenase subunit E2 61897 1197831 BMEII0060 Brucella melitensis bv. 1 str. 16M branched-chain alpha-keto acid dehydrogenase subunit E2 NP_541037.1 60632 R 224914 CDS NP_541038.1 17988405 1197832 complement(61916..64105) 1 NC_003318.1 2-oxoisovalerate dehydrogenase subunit beta 64105 1197832 BMEII0061 Brucella melitensis bv. 1 str. 16M 2-oxoisovalerate dehydrogenase subunit beta NP_541038.1 61916 R 224914 CDS NP_541039.1 17988406 1197833 complement(64215..64736) 1 NC_003318.1 carbonyl reductase 64736 1197833 BMEII0062 Brucella melitensis bv. 1 str. 16M carbonyl reductase NP_541039.1 64215 R 224914 CDS NP_541040.1 17988407 1197834 complement(64985..65722) 1 NC_003318.1 3-oxoacyl-ACP reductase 65722 1197834 BMEII0063 Brucella melitensis bv. 1 str. 16M 3-oxoacyl-ACP reductase NP_541040.1 64985 R 224914 CDS NP_541041.1 17988408 1197835 complement(65726..66208) 1 NC_003318.1 lactoylglutathione lyase 66208 1197835 BMEII0064 Brucella melitensis bv. 1 str. 16M lactoylglutathione lyase NP_541041.1 65726 R 224914 CDS NP_541042.1 17988409 1197836 complement(66260..66976) 1 NC_003318.1 high-affinity branched-chain amino acid transport ATP-binding protein LIVF 66976 1197836 BMEII0065 Brucella melitensis bv. 1 str. 16M high-affinity branched-chain amino acid transport ATP-binding protein LIVF NP_541042.1 66260 R 224914 CDS NP_541043.1 17988410 1197837 complement(66976..67731) 1 NC_003318.1 high-affinity branched-chain amino acid transport ATP-binding protein LIVG 67731 1197837 BMEII0066 Brucella melitensis bv. 1 str. 16M high-affinity branched-chain amino acid transport ATP-binding protein LIVG NP_541043.1 66976 R 224914 CDS NP_541044.1 17988411 1197838 complement(67728..68948) 1 NC_003318.1 high-affinity branched-chain amino acid transport system permease LIVM 68948 1197838 BMEII0067 Brucella melitensis bv. 1 str. 16M high-affinity branched-chain amino acid transport system permease LIVM NP_541044.1 67728 R 224914 CDS NP_541045.1 17988412 1197839 complement(68952..69950) 1 NC_003318.1 high-affinity branched-chain amino acid transport system permease livH 69950 1197839 BMEII0068 Brucella melitensis bv. 1 str. 16M high-affinity branched-chain amino acid transport system permease livH NP_541045.1 68952 R 224914 CDS NP_541046.1 17988413 1197840 complement(69992..70678) 1 NC_003318.1 leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein precursor 70678 1197840 BMEII0069 Brucella melitensis bv. 1 str. 16M leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein precursor NP_541046.1 69992 R 224914 CDS NP_541047.1 17988414 1197841 complement(70700..71242) 1 NC_003318.1 leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein precursor 71242 1197841 BMEII0070 Brucella melitensis bv. 1 str. 16M leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein precursor NP_541047.1 70700 R 224914 CDS NP_541048.1 17988415 1197842 71453..72265 1 NC_003318.1 GntR family transcriptional regulator 72265 1197842 BMEII0071 Brucella melitensis bv. 1 str. 16M GntR family transcriptional regulator NP_541048.1 71453 D 224914 CDS NP_541049.1 17988416 1197843 complement(72311..73552) 1 NC_003318.1 extracytoplasmic function alternative sigma factor 73552 1197843 BMEII0072 Brucella melitensis bv. 1 str. 16M extracytoplasmic function alternative sigma factor NP_541049.1 72311 R 224914 CDS NP_541050.1 17988417 1197844 73614..73928 1 NC_003318.1 hypothetical protein 73928 1197844 BMEII0073 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541050.1 73614 D 224914 CDS NP_541051.1 17988418 1197845 74255..74800 1 NC_003318.1 hypothetical protein 74800 1197845 BMEII0074 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541051.1 74255 D 224914 CDS NP_541052.1 17988419 1197846 74797..75585 1 NC_003318.1 nitrate reductase 75585 1197846 BMEII0075 Brucella melitensis bv. 1 str. 16M nitrate reductase NP_541052.1 74797 D 224914 CDS NP_541053.1 17988420 1197847 complement(75633..77042) 1 NC_003318.1 enterobactin synthetase subunit F 77042 1197847 BMEII0076 Brucella melitensis bv. 1 str. 16M enterobactin synthetase subunit F NP_541053.1 75633 R 224914 CDS NP_541054.1 17988421 1197848 77033..78289 1 NC_003318.1 synthesizes isochorismate acid from chorismate; isochorismate synthase 78289 1197848 BMEII0077 Brucella melitensis bv. 1 str. 16M isochorismate synthase NP_541054.1 77033 D 224914 CDS NP_541055.2 161511180 1197849 78396..80015 1 NC_003318.1 bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate; enterobactin synthase subunit E 80015 entE 1197849 entE Brucella melitensis bv. 1 str. 16M enterobactin synthase subunit E NP_541055.2 78396 D 224914 CDS NP_541056.1 17988423 1197850 80067..80939 1 NC_003318.1 isochorismatase 80939 1197850 BMEII0079 Brucella melitensis bv. 1 str. 16M isochorismatase NP_541056.1 80067 D 224914 CDS NP_541057.1 17988424 1197851 80900..81715 1 NC_003318.1 catalyzes the formation of 2,3-dihydroxybenzoate from 2,3-dihydro-2,3-dihydroxybenzoate; involved in the biosynthesis of siderophores, enterobactin, bacillibactin or vibriobactin; 2,3-dihydroxybenzoate-2,3-dehydrogenase 81715 1197851 BMEII0080 Brucella melitensis bv. 1 str. 16M 2,3-dihydroxybenzoate-2,3-dehydrogenase NP_541057.1 80900 D 224914 CDS NP_541058.1 17988425 1197852 81690..82430 1 NC_003318.1 enterobactin synthetase subunit D 82430 1197852 BMEII0081 Brucella melitensis bv. 1 str. 16M enterobactin synthetase subunit D NP_541058.1 81690 D 224914 CDS NP_541059.1 17988426 1197853 complement(82402..83010) 1 NC_003318.1 hypothetical protein 83010 1197853 BMEII0082 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541059.1 82402 R 224914 CDS NP_541060.1 17988427 1197854 83254..83820 1 NC_003318.1 basic membrane protein A precursor 83820 1197854 BMEII0083 Brucella melitensis bv. 1 str. 16M basic membrane protein A precursor NP_541060.1 83254 D 224914 CDS NP_541061.1 17988428 1197855 83884..84360 1 NC_003318.1 basic membrane protein A precursor 84360 1197855 BMEII0084 Brucella melitensis bv. 1 str. 16M basic membrane protein A precursor NP_541061.1 83884 D 224914 CDS NP_541062.1 17988429 1197856 84363..85934 1 NC_003318.1 galactoside transport ATP-binding protein mglA 85934 1197856 BMEII0085 Brucella melitensis bv. 1 str. 16M galactoside transport ATP-binding protein mglA NP_541062.1 84363 D 224914 CDS NP_541063.1 17988430 1197857 85996..87075 1 NC_003318.1 galactoside transport system permease mglC 87075 1197857 BMEII0086 Brucella melitensis bv. 1 str. 16M galactoside transport system permease mglC NP_541063.1 85996 D 224914 CDS NP_541064.1 17988431 1197858 87072..87983 1 NC_003318.1 sugar ABC transporter, permease 87983 1197858 BMEII0087 Brucella melitensis bv. 1 str. 16M sugar ABC transporter, permease NP_541064.1 87072 D 224914 CDS NP_541065.1 17988432 1197859 88009..89004 1 NC_003318.1 inosine-uridine preferring nucleoside hydrolase 89004 1197859 BMEII0088 Brucella melitensis bv. 1 str. 16M inosine-uridine preferring nucleoside hydrolase NP_541065.1 88009 D 224914 CDS NP_541066.1 17988433 1197860 complement(89081..90022) 1 NC_003318.1 ribokinase 90022 1197860 BMEII0089 Brucella melitensis bv. 1 str. 16M ribokinase NP_541066.1 89081 R 224914 CDS NP_541067.1 17988434 1197861 90333..90533 1 NC_003318.1 hypothetical protein 90533 1197861 BMEII0090 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541067.1 90333 D 224914 CDS NP_541068.1 17988435 1197862 complement(90768..91934) 1 NC_003318.1 replication initiation protein RepC 91934 1197862 BMEII0091 Brucella melitensis bv. 1 str. 16M replication initiation protein RepC NP_541068.1 90768 R 224914 CDS NP_541069.1 17988436 1197863 complement(92332..93318) 1 NC_003318.1 replication protein B 93318 1197863 BMEII0092 Brucella melitensis bv. 1 str. 16M replication protein B NP_541069.1 92332 R 224914 CDS NP_541070.1 17988437 1197864 complement(93383..94576) 1 NC_003318.1 replication protein A 94576 1197864 BMEII0093 Brucella melitensis bv. 1 str. 16M replication protein A NP_541070.1 93383 R 224914 CDS NP_541071.1 17988438 1197865 94790..95194 1 NC_003318.1 hypothetical protein 95194 1197865 BMEII0094 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541071.1 94790 D 224914 CDS NP_541072.1 17988439 1197866 95161..95385 1 NC_003318.1 hypothetical protein 95385 1197866 BMEII0095 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541072.1 95161 D 224914 CDS NP_541073.1 17988440 1197867 95406..96830 1 NC_003318.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 96830 1197867 BMEII0096 Brucella melitensis bv. 1 str. 16M coproporphyrinogen III oxidase NP_541073.1 95406 D 224914 CDS NP_541074.1 17988441 1197868 97029..99050 1 NC_003318.1 cation-transporting P-type ATPase B 99050 1197868 BMEII0097 Brucella melitensis bv. 1 str. 16M cation-transporting P-type ATPase B NP_541074.1 97029 D 224914 CDS NP_541075.1 17988442 1197869 complement(99079..99807) 1 NC_003318.1 high-affinity branched-chain amino acid transport ATP-binding protein LIVF 99807 1197869 BMEII0098 Brucella melitensis bv. 1 str. 16M high-affinity branched-chain amino acid transport ATP-binding protein LIVF NP_541075.1 99079 R 224914 CDS NP_541076.1 17988443 1197870 complement(99804..100421) 1 NC_003318.1 high-affinity branched-chain amino acid transport ATP-binding protein LIVG 100421 1197870 BMEII0099 Brucella melitensis bv. 1 str. 16M high-affinity branched-chain amino acid transport ATP-binding protein LIVG NP_541076.1 99804 R 224914 CDS NP_541077.1 17988444 1197871 complement(100243..100536) 1 NC_003318.1 high-affinity branched-chain amino acid transport ATP-binding protein LIVG 100536 1197871 BMEII0100 Brucella melitensis bv. 1 str. 16M high-affinity branched-chain amino acid transport ATP-binding protein LIVG NP_541077.1 100243 R 224914 CDS NP_541078.1 17988445 1197872 complement(100533..101480) 1 NC_003318.1 high-affinity branched-chain amino acid transport system permease LIVM 101480 1197872 BMEII0101 Brucella melitensis bv. 1 str. 16M high-affinity branched-chain amino acid transport system permease LIVM NP_541078.1 100533 R 224914 CDS NP_541079.1 17988446 1197873 complement(101477..102340) 1 NC_003318.1 high-affinity branched-chain amino acid transport system permease livH 102340 1197873 BMEII0102 Brucella melitensis bv. 1 str. 16M high-affinity branched-chain amino acid transport system permease livH NP_541079.1 101477 R 224914 CDS NP_541080.1 17988447 1197874 complement(102542..103789) 1 NC_003318.1 Leu/Ile/Val-binding protein precursor 103789 1197874 BMEII0103 Brucella melitensis bv. 1 str. 16M Leu/Ile/Val-binding protein precursor NP_541080.1 102542 R 224914 CDS NP_541081.1 17988448 1197875 complement(103912..104613) 1 NC_003318.1 AraC family transcriptional regulator 104613 1197875 BMEII0104 Brucella melitensis bv. 1 str. 16M AraC family transcriptional regulator NP_541081.1 103912 R 224914 CDS NP_541082.1 17988449 1197876 105179..107143 1 NC_003318.1 iron-regulated outer membrane protein FrpB 107143 1197876 BMEII0105 Brucella melitensis bv. 1 str. 16M iron-regulated outer membrane protein FrpB NP_541082.1 105179 D 224914 CDS NP_541083.1 17988450 1197877 107399..108523 1 NC_003318.1 xylose repressor 108523 1197877 BMEII0106 Brucella melitensis bv. 1 str. 16M xylose repressor NP_541083.1 107399 D 224914 CDS NP_541084.1 17988451 1197878 108520..109260 1 NC_003318.1 taurine transport system permease TAUC 109260 1197878 BMEII0107 Brucella melitensis bv. 1 str. 16M taurine transport system permease TAUC NP_541084.1 108520 D 224914 CDS NP_541085.1 17988452 1197879 109254..109982 1 NC_003318.1 taurine transport ATP-binding protein TAUB 109982 1197879 BMEII0108 Brucella melitensis bv. 1 str. 16M taurine transport ATP-binding protein TAUB NP_541085.1 109254 D 224914 CDS NP_541086.1 17988453 1197880 109998..110957 1 NC_003318.1 aliphatic sulfonates-binding lipoprotein 110957 1197880 BMEII0109 Brucella melitensis bv. 1 str. 16M aliphatic sulfonates-binding lipoprotein NP_541086.1 109998 D 224914 CDS NP_541087.1 17988454 1197881 111100..112587 1 NC_003318.1 choline-sulfatase 112587 1197881 BMEII0110 Brucella melitensis bv. 1 str. 16M choline-sulfatase NP_541087.1 111100 D 224914 CDS NP_541088.1 17988455 1197882 112862..113707 1 NC_003318.1 metallophosphoesterase 113707 1197882 BMEII0111 Brucella melitensis bv. 1 str. 16M metallophosphoesterase NP_541088.1 112862 D 224914 CDS NP_541089.1 17988456 1197883 113704..114876 1 NC_003318.1 SN-glycerol-3-phosphate transport ATP-binding protein ugpC 114876 1197883 BMEII0112 Brucella melitensis bv. 1 str. 16M SN-glycerol-3-phosphate transport ATP-binding protein ugpC NP_541089.1 113704 D 224914 CDS NP_541090.1 17988457 1197884 114989..115801 1 NC_003318.1 SN-glycerol-3-phosphate transport system permease UGPA 115801 1197884 BMEII0113 Brucella melitensis bv. 1 str. 16M SN-glycerol-3-phosphate transport system permease UGPA NP_541090.1 114989 D 224914 CDS NP_541091.1 17988458 1197885 115812..116633 1 NC_003318.1 SN-glycerol-3-phosphate transport system permease UGPE 116633 1197885 BMEII0114 Brucella melitensis bv. 1 str. 16M SN-glycerol-3-phosphate transport system permease UGPE NP_541091.1 115812 D 224914 CDS NP_541092.1 17988459 1197886 116668..117933 1 NC_003318.1 glycerol-3-phosphate-binding periplasmic protein precursor 117933 1197886 BMEII0115 Brucella melitensis bv. 1 str. 16M glycerol-3-phosphate-binding periplasmic protein precursor NP_541092.1 116668 D 224914 CDS NP_541093.1 17988460 1197887 118078..118812 1 NC_003318.1 GntR family transcriptional regulator 118812 1197887 BMEII0116 Brucella melitensis bv. 1 str. 16M GntR family transcriptional regulator NP_541093.1 118078 D 224914 CDS NP_541094.1 17988461 1197888 118908..119687 1 NC_003318.1 hypothetical protein 119687 1197888 BMEII0117 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541094.1 118908 D 224914 CDS NP_541095.1 17988462 1197889 119702..120025 1 NC_003318.1 hypothetical protein 120025 1197889 BMEII0118 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541095.1 119702 D 224914 CDS NP_541096.1 17988463 1197890 complement(120120..120824) 1 NC_003318.1 high-affinity branched-chain amino acid transport ATP-binding protein LIVF 120824 1197890 BMEII0119 Brucella melitensis bv. 1 str. 16M high-affinity branched-chain amino acid transport ATP-binding protein LIVF NP_541096.1 120120 R 224914 CDS NP_541097.1 17988464 1197891 complement(120821..122368) 1 NC_003318.1 high-affinity branched-chain amino acid transport system permease LIVM / high-affinity branched-chain amino acid transport ATP-binding protein LIVG 122368 1197891 BMEII0120 Brucella melitensis bv. 1 str. 16M high-affinity branched-chain amino acid transport system permease LIVM / high-affinity branched-chain amino acid transport ATP-binding protein LIVG NP_541097.1 120821 R 224914 CDS NP_541098.1 17988465 1197892 complement(122520..123398) 1 NC_003318.1 high-affinity branched-chain amino acid transport system permease livH 123398 1197892 BMEII0121 Brucella melitensis bv. 1 str. 16M high-affinity branched-chain amino acid transport system permease livH NP_541098.1 122520 R 224914 CDS NP_541099.1 17988466 1197893 complement(123462..124604) 1 NC_003318.1 leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein precursor 124604 1197893 BMEII0122 Brucella melitensis bv. 1 str. 16M leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein precursor NP_541099.1 123462 R 224914 CDS NP_541100.1 17988467 1197894 complement(124710..126392) 1 NC_003318.1 exoenzymes regulatory protein AEPA precursor 126392 1197894 BMEII0123 Brucella melitensis bv. 1 str. 16M exoenzymes regulatory protein AEPA precursor NP_541100.1 124710 R 224914 CDS NP_541101.1 17988468 1197895 complement(126551..127006) 1 NC_003318.1 aldehyde dehydrogenase 127006 1197895 BMEII0124 Brucella melitensis bv. 1 str. 16M aldehyde dehydrogenase NP_541101.1 126551 R 224914 CDS NP_541102.1 17988469 1197896 complement(127003..128025) 1 NC_003318.1 aldehyde dehydrogenase 128025 1197896 BMEII0125 Brucella melitensis bv. 1 str. 16M aldehyde dehydrogenase NP_541102.1 127003 R 224914 CDS NP_541103.1 17988470 1197897 complement(128097..129590) 1 NC_003318.1 amino acid permease 129590 1197897 BMEII0126 Brucella melitensis bv. 1 str. 16M amino acid permease NP_541103.1 128097 R 224914 CDS NP_541104.1 17988471 1197898 129836..130621 1 NC_003318.1 acetate operon repressor 130621 1197898 BMEII0127 Brucella melitensis bv. 1 str. 16M acetate operon repressor NP_541104.1 129836 D 224914 CDS NP_541105.1 17988472 1197899 130621..131877 1 NC_003318.1 hypothetical protein 131877 1197899 BMEII0128 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541105.1 130621 D 224914 CDS NP_541106.1 17988473 1197900 131874..132518 1 NC_003318.1 hydrolase 132518 1197900 BMEII0129 Brucella melitensis bv. 1 str. 16M hydrolase NP_541106.1 131874 D 224914 CDS NP_541107.1 17988474 1197901 132531..133889 1 NC_003318.1 hypothetical protein 133889 1197901 BMEII0130 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541107.1 132531 D 224914 CDS NP_541108.1 17988475 1197902 133843..135174 1 NC_003318.1 4-aminobutyrate aminotransferase 135174 1197902 BMEII0131 Brucella melitensis bv. 1 str. 16M 4-aminobutyrate aminotransferase NP_541108.1 133843 D 224914 CDS NP_541109.1 17988476 1197903 135251..136171 1 NC_003318.1 homoserine kinase 136171 1197903 BMEII0132 Brucella melitensis bv. 1 str. 16M homoserine kinase NP_541109.1 135251 D 224914 CDS NP_541110.1 17988477 1197904 complement(136161..136652) 1 NC_003318.1 homoprotocatechuate degradative operon repressor 136652 1197904 BMEII0133 Brucella melitensis bv. 1 str. 16M homoprotocatechuate degradative operon repressor NP_541110.1 136161 R 224914 CDS NP_541111.1 17988478 1197905 136808..137200 1 NC_003318.1 5-carboxymethyl-2-hydroxymuconate delta-isomerase 137200 1197905 BMEII0134 Brucella melitensis bv. 1 str. 16M 5-carboxymethyl-2-hydroxymuconate delta-isomerase NP_541111.1 136808 D 224914 CDS NP_541112.1 17988479 1197906 137270..138784 1 NC_003318.1 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase 138784 1197906 BMEII0135 Brucella melitensis bv. 1 str. 16M 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase NP_541112.1 137270 D 224914 CDS NP_541113.1 17988480 1197907 138824..139819 1 NC_003318.1 homoprotocatechuate 2,3-dioxygenase 139819 1197907 BMEII0136 Brucella melitensis bv. 1 str. 16M homoprotocatechuate 2,3-dioxygenase NP_541113.1 138824 D 224914 CDS NP_541114.1 17988481 1197908 139819..140754 1 NC_003318.1 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase 140754 1197908 BMEII0137 Brucella melitensis bv. 1 str. 16M 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase NP_541114.1 139819 D 224914 CDS NP_541115.1 17988482 1197909 140758..141561 1 NC_003318.1 2-oxo-hepta-3-ene-1,7-dioic acid hydratase 141561 1197909 BMEII0138 Brucella melitensis bv. 1 str. 16M 2-oxo-hepta-3-ene-1,7-dioic acid hydratase NP_541115.1 140758 D 224914 CDS NP_541116.1 17988483 1197910 141779..142588 1 NC_003318.1 phosphotyrosyl phosphatase activator (PTPA) 142588 1197910 BMEII0139 Brucella melitensis bv. 1 str. 16M phosphotyrosyl phosphatase activator (PTPA) NP_541116.1 141779 D 224914 CDS NP_541117.1 17988484 1197911 complement(142745..142921) 1 NC_003318.1 aldehyde dehydrogenase 142921 1197911 BMEII0140 Brucella melitensis bv. 1 str. 16M aldehyde dehydrogenase NP_541117.1 142745 R 224914 CDS NP_541118.1 17988485 1197912 complement(142982..143797) 1 NC_003318.1 aldehyde dehydrogenase 143797 1197912 BMEII0141 Brucella melitensis bv. 1 str. 16M aldehyde dehydrogenase NP_541118.1 142982 R 224914 CDS NP_541119.1 17988486 1197913 complement(143828..144151) 1 NC_003318.1 aldehyde dehydrogenase 144151 1197913 BMEII0142 Brucella melitensis bv. 1 str. 16M aldehyde dehydrogenase NP_541119.1 143828 R 224914 CDS NP_541120.1 17988487 1197914 complement(144251..145219) 1 NC_003318.1 AraC family transcriptional regulator 145219 1197914 BMEII0143 Brucella melitensis bv. 1 str. 16M AraC family transcriptional regulator NP_541120.1 144251 R 224914 CDS NP_541121.1 17988488 1197915 complement(145777..146946) 1 NC_003318.1 xylose transport system permease XYLH 146946 1197915 BMEII0144 Brucella melitensis bv. 1 str. 16M xylose transport system permease XYLH NP_541121.1 145777 R 224914 CDS NP_541122.1 17988489 1197916 complement(147089..148627) 1 NC_003318.1 with XylFH is part of the high affinity xylose ABC transporter; xylose transporter ATP-binding subunit 148627 1197916 BMEII0145 Brucella melitensis bv. 1 str. 16M xylose transporter ATP-binding subunit NP_541122.1 147089 R 224914 CDS NP_541123.1 17988490 1197917 complement(148786..149745) 1 NC_003318.1 D-xylose-binding periplasmic protein precursor 149745 1197917 BMEII0146 Brucella melitensis bv. 1 str. 16M D-xylose-binding periplasmic protein precursor NP_541123.1 148786 R 224914 CDS NP_541124.1 17988491 1197918 150379..151434 1 NC_003318.1 integral membrane protein 151434 1197918 BMEII0147 Brucella melitensis bv. 1 str. 16M integral membrane protein NP_541124.1 150379 D 224914 CDS NP_541125.1 17988492 1197919 complement(151551..159215) 1 NC_003318.1 serine protease 159215 1197919 BMEII0148 Brucella melitensis bv. 1 str. 16M serine protease NP_541125.1 151551 R 224914 CDS NP_541126.1 17988493 1197920 complement(159847..161622) 1 NC_003318.1 serine protease 161622 1197920 BMEII0149 Brucella melitensis bv. 1 str. 16M serine protease NP_541126.1 159847 R 224914 CDS NP_541127.1 17988494 1197921 162455..163303 1 NC_003318.1 flagellin 163303 1197921 BMEII0150 Brucella melitensis bv. 1 str. 16M flagellin NP_541127.1 162455 D 224914 CDS NP_541128.1 17988495 1197922 163506..164234 1 NC_003318.1 flagellar M-ring protein FLIF 164234 1197922 BMEII0151 Brucella melitensis bv. 1 str. 16M flagellar M-ring protein FLIF NP_541128.1 163506 D 224914 CDS NP_541129.1 17988496 1197923 164247..165248 1 NC_003318.1 flagellar M-ring protein FLIF 165248 1197923 BMEII0152 Brucella melitensis bv. 1 str. 16M flagellar M-ring protein FLIF NP_541129.1 164247 D 224914 CDS NP_541130.1 17988497 1197924 165251..165931 1 NC_003318.1 hypothetical protein 165931 1197924 BMEII0153 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541130.1 165251 D 224914 CDS NP_541131.1 17988498 1197925 165928..167028 1 NC_003318.1 with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotB 167028 motB 1197925 motB Brucella melitensis bv. 1 str. 16M flagellar motor protein MotB NP_541131.1 165928 D 224914 CDS NP_541132.2 161511179 1197926 167025..168317 1 NC_003318.1 a periplasmic protein that interacts with and stabilizes MotB; in Rhizobium, interactions between MotB and MotC at the periplasmic surface of the motor control the energy flux or the energy coupling that drives flagellar rotation; chemotaxis protein 168317 1197926 BMEII0155 Brucella melitensis bv. 1 str. 16M chemotaxis protein NP_541132.2 167025 D 224914 CDS NP_541133.1 17988500 1197927 168389..169588 1 NC_003318.1 chemotaxis MotD protein 169588 1197927 BMEII0156 Brucella melitensis bv. 1 str. 16M chemotaxis MotD protein NP_541133.1 168389 D 224914 CDS NP_541134.1 17988501 1197928 169542..170114 1 NC_003318.1 hypothetical protein 170114 1197928 BMEII0157 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541134.1 169542 D 224914 CDS NP_541135.1 17988502 1197929 170442..171125 1 NC_003318.1 two component response regulator 171125 1197929 BMEII0158 Brucella melitensis bv. 1 str. 16M two component response regulator NP_541135.1 170442 D 224914 CDS NP_541136.1 17988503 1197930 171536..172726 1 NC_003318.1 the hook connects flagellar basal body to the flagellar filament; flagellar hook protein FlgE 172726 flgE 1197930 flgE Brucella melitensis bv. 1 str. 16M flagellar hook protein FlgE NP_541136.1 171536 D 224914 CDS NP_541137.1 17988504 1197931 172851..174305 1 NC_003318.1 with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook; flagellar hook-associated protein FlgK 174305 flgK 1197931 flgK Brucella melitensis bv. 1 str. 16M flagellar hook-associated protein FlgK NP_541137.1 172851 D 224914 CDS NP_541138.1 17988505 1197932 174311..175357 1 NC_003318.1 with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; Bradyrhizobium has one thick flagellum and several thin flagella; the Bradyrhizobium protein in this cluster is associated with the thin flagella; flagellar hook-associated protein FlgL 175357 flgL 1197932 flgL Brucella melitensis bv. 1 str. 16M flagellar hook-associated protein FlgL NP_541138.1 174311 D 224914 CDS NP_541139.1 17988506 1197933 175489..175833 1 NC_003318.1 acts as an activator or flagellin translation and may be required for filament secretion or assembly; Bradyrhizobium has one thick flagellum and several thin flagella; the protein in this cluster is associated with the thin flagella; flagellar biosynthesis regulatory protein FlaF 175833 flaF 1197933 flaF Brucella melitensis bv. 1 str. 16M flagellar biosynthesis regulatory protein FlaF NP_541139.1 175489 D 224914 CDS NP_541140.1 17988507 1197934 175835..176293 1 NC_003318.1 post-transcriptional repressor of flagellum biosynthesis; promotes degradation of fljK mRNA: Bradyrhizobium has one thick flagellum and several thin flagella; the protein in this cluster is associated with the thin flagella; flagellar biosynthesis repressor FlbT 176293 flbT 1197934 flbT Brucella melitensis bv. 1 str. 16M flagellar biosynthesis repressor FlbT NP_541140.1 175835 D 224914 CDS NP_541141.1 17988508 1197935 176290..176703 1 NC_003318.1 acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; Bradyrhizobium has one thick flagellum and several thin flagella; the protein in this cluster is associated with the thin flagella; flagellar basal body rod modification protein 176703 flgD 1197935 flgD Brucella melitensis bv. 1 str. 16M flagellar basal body rod modification protein NP_541141.1 176290 D 224914 CDS NP_541142.1 17988509 1197936 176715..176981 1 NC_003318.1 FliQ, with proteins FliP and FliR, forms the core of the central channel in the flagella export apparatus; Bradyrhizobium have one thick flagellum and several thin flagella; the protein in this cluster is associated with the thick flagellum; flagellar biosynthesis protein FliQ 176981 fliQ 1197936 fliQ Brucella melitensis bv. 1 str. 16M flagellar biosynthesis protein FliQ NP_541142.1 176715 D 224914 CDS NP_541143.1 17988510 1197937 177142..177441 1 NC_003318.1 flagellar biosynthetic protein FlhA 177441 1197937 BMEII0166 Brucella melitensis bv. 1 str. 16M flagellar biosynthetic protein FlhA NP_541143.1 177142 D 224914 CDS NP_541144.1 17988511 1197938 177463..179232 1 NC_003318.1 flagellar biosynthesis protein 179232 1197938 BMEII0167 Brucella melitensis bv. 1 str. 16M flagellar biosynthesis protein NP_541144.1 177463 D 224914 CDS NP_541145.1 17988512 1197939 179248..180015 1 NC_003318.1 FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliR 180015 fliR 1197939 fliR Brucella melitensis bv. 1 str. 16M flagellar biosynthesis protein FliR NP_541145.1 179248 D 224914 CDS NP_541146.1 17988513 1197940 180059..180430 1 NC_003318.1 hypothetical protein 180430 1197940 BMEII0169 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541146.1 180059 D 224914 CDS NP_541147.1 17988514 1197941 180612..181088 1 NC_003318.1 flagellar protein FLGJ 181088 1197941 BMEII0170 Brucella melitensis bv. 1 str. 16M flagellar protein FLGJ NP_541147.1 180612 D 224914 CDS NP_541148.1 17988515 1197942 181344..181691 1 NC_003318.1 cytoplasmic protein 181691 1197942 BMEII0171 Brucella melitensis bv. 1 str. 16M cytoplasmic protein NP_541148.1 181344 D 224914 CDS NP_541149.1 17988516 1197943 181688..182215 1 NC_003318.1 hypothetical protein 182215 1197943 BMEII0172 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541149.1 181688 D 224914 CDS NP_541150.1 17988517 1197944 complement(182203..182418) 1 NC_003318.1 hypothetical protein 182418 1197944 BMEII0173 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541150.1 182203 R 224914 CDS NP_541151.1 17988518 1197945 182408..182641 1 NC_003318.1 hypothetical protein 182641 1197945 BMEII0174 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541151.1 182408 D 224914 CDS NP_541152.1 17988519 1197946 complement(182666..183103) 1 NC_003318.1 zinc uptake regulation protein 183103 1197946 BMEII0175 Brucella melitensis bv. 1 str. 16M zinc uptake regulation protein NP_541152.1 182666 R 224914 CDS NP_541153.1 17988520 1197947 complement(183100..183954) 1 NC_003318.1 high-affinity zinc uptake system membrane protein ZNUB 183954 1197947 BMEII0176 Brucella melitensis bv. 1 str. 16M high-affinity zinc uptake system membrane protein ZNUB NP_541153.1 183100 R 224914 CDS NP_541154.1 17988521 1197948 complement(183914..184810) 1 NC_003318.1 high-affinity zinc uptake system ATP-binding protein ZNUC 184810 1197948 BMEII0177 Brucella melitensis bv. 1 str. 16M high-affinity zinc uptake system ATP-binding protein ZNUC NP_541154.1 183914 R 224914 CDS NP_541155.1 17988522 1197949 185055..186041 1 NC_003318.1 high-affinity zinc uptake system protein ZNUA 186041 1197949 BMEII0178 Brucella melitensis bv. 1 str. 16M high-affinity zinc uptake system protein ZNUA NP_541155.1 185055 D 224914 CDS NP_541156.1 17988523 1197950 186208..187410 1 NC_003318.1 zinc transporter 187410 1197950 BMEII0179 Brucella melitensis bv. 1 str. 16M zinc transporter NP_541156.1 186208 D 224914 CDS NP_541157.1 17988524 1197951 complement(187471..187959) 1 NC_003318.1 RRF2 family protein 187959 1197951 BMEII0180 Brucella melitensis bv. 1 str. 16M RRF2 family protein NP_541157.1 187471 R 224914 CDS NP_541158.1 17988525 1197952 complement(188182..189063) 1 NC_003318.1 N-acetylglucosamine kinase 189063 1197952 BMEII0181 Brucella melitensis bv. 1 str. 16M N-acetylglucosamine kinase NP_541158.1 188182 R 224914 CDS NP_541159.1 17988526 1197953 189042..189260 1 NC_003318.1 hypothetical protein 189260 1197953 BMEII0182 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541159.1 189042 D 224914 CDS NP_541160.1 17988527 1197954 complement(195542..196444) 1 NC_003318.1 transposase 196444 1197954 BMEII0183 Brucella melitensis bv. 1 str. 16M transposase NP_541160.1 195542 R 224914 CDS NP_541161.1 17988528 1197955 complement(196441..196722) 1 NC_003318.1 transposase 196722 1197955 BMEII0184 Brucella melitensis bv. 1 str. 16M transposase NP_541161.1 196441 R 224914 CDS NP_541162.1 17988529 1197956 197140..197658 1 NC_003318.1 D-lactate dehydrogenase 197658 1197956 BMEII0185 Brucella melitensis bv. 1 str. 16M D-lactate dehydrogenase NP_541162.1 197140 D 224914 CDS NP_541163.1 17988530 1197957 198089..198373 1 NC_003318.1 PEMK-like protein 1 198373 1197957 BMEII0186 Brucella melitensis bv. 1 str. 16M PEMK-like protein 1 NP_541163.1 198089 D 224914 CDS NP_541164.1 17988531 1197958 complement(198382..198894) 1 NC_003318.1 cytoplasmic protein 198894 1197958 BMEII0187 Brucella melitensis bv. 1 str. 16M cytoplasmic protein NP_541164.1 198382 R 224914 CDS NP_541165.1 17988532 1197959 complement(198872..200128) 1 NC_003318.1 cytoplasmic protein 200128 1197959 BMEII0188 Brucella melitensis bv. 1 str. 16M cytoplasmic protein NP_541165.1 198872 R 224914 CDS NP_541166.1 17988533 1197960 complement(200223..200957) 1 NC_003318.1 L-fuculose phosphate aldolase 200957 1197960 BMEII0189 Brucella melitensis bv. 1 str. 16M L-fuculose phosphate aldolase NP_541166.1 200223 R 224914 CDS NP_541167.1 17988534 1197961 complement(201078..201704) 1 NC_003318.1 hypothetical protein 201704 1197961 BMEII0190 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541167.1 201078 R 224914 CDS NP_541168.1 17988535 1197962 complement(201777..202727) 1 NC_003318.1 hypothetical protein 202727 1197962 BMEII0191 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541168.1 201777 R 224914 CDS NP_541169.1 17988536 1197963 complement(202907..204142) 1 NC_003318.1 glutamate-1-semialdehyde 2,1-aminomutase 204142 1197963 BMEII0192 Brucella melitensis bv. 1 str. 16M glutamate-1-semialdehyde 2,1-aminomutase NP_541169.1 202907 R 224914 CDS NP_541170.1 17988537 1197964 204369..205517 1 NC_003318.1 spermidine/putrescine ABC transporter ATP-binding protein 205517 1197964 BMEII0193 Brucella melitensis bv. 1 str. 16M spermidine/putrescine ABC transporter ATP-binding protein NP_541170.1 204369 D 224914 CDS NP_541171.1 17988538 1197965 205633..206388 1 NC_003318.1 spermidine/putrescine ABC transporter permease 206388 1197965 BMEII0194 Brucella melitensis bv. 1 str. 16M spermidine/putrescine ABC transporter permease NP_541171.1 205633 D 224914 CDS NP_541172.1 17988539 1197966 206427..207188 1 NC_003318.1 spermidine/putrescine ABC transporter permease 207188 1197966 BMEII0195 Brucella melitensis bv. 1 str. 16M spermidine/putrescine ABC transporter permease NP_541172.1 206427 D 224914 CDS NP_541173.1 17988540 1197967 207181..208263 1 NC_003318.1 spermidine/putrescine-binding periplasmic protein 208263 1197967 BMEII0196 Brucella melitensis bv. 1 str. 16M spermidine/putrescine-binding periplasmic protein NP_541173.1 207181 D 224914 CDS NP_541174.1 17988541 1197968 complement(208309..209727) 1 NC_003318.1 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia; amidase 209727 1197968 BMEII0197 Brucella melitensis bv. 1 str. 16M amidase NP_541174.1 208309 R 224914 CDS NP_541175.1 17988542 1197969 complement(209742..210614) 1 NC_003318.1 antibiotic-induced protein Drp35 210614 1197969 BMEII0198 Brucella melitensis bv. 1 str. 16M antibiotic-induced protein Drp35 NP_541175.1 209742 R 224914 CDS NP_541176.1 17988543 1197970 complement(210614..211720) 1 NC_003318.1 oligopeptide transport ATP-binding protein OPPF 211720 1197970 BMEII0199 Brucella melitensis bv. 1 str. 16M oligopeptide transport ATP-binding protein OPPF NP_541176.1 210614 R 224914 CDS NP_541177.1 17988544 1197971 complement(211588..212721) 1 NC_003318.1 oligopeptide transport ATP-binding protein OPPD 212721 1197971 BMEII0200 Brucella melitensis bv. 1 str. 16M oligopeptide transport ATP-binding protein OPPD NP_541177.1 211588 R 224914 CDS NP_541178.1 17988545 1197972 complement(212580..213413) 1 NC_003318.1 oligopeptide transport system permease OPPC 213413 1197972 BMEII0201 Brucella melitensis bv. 1 str. 16M oligopeptide transport system permease OPPC NP_541178.1 212580 R 224914 CDS NP_541179.1 17988546 1197973 complement(213410..214420) 1 NC_003318.1 oligopeptide transport system permease OPPB 214420 1197973 BMEII0202 Brucella melitensis bv. 1 str. 16M oligopeptide transport system permease OPPB NP_541179.1 213410 R 224914 CDS NP_541180.1 17988547 1197974 complement(214456..216012) 1 NC_003318.1 binding protein YDDS precursor 216012 1197974 BMEII0203 Brucella melitensis bv. 1 str. 16M binding protein YDDS precursor NP_541180.1 214456 R 224914 CDS NP_541181.1 17988548 1197975 complement(216078..216560) 1 NC_003318.1 GntR family transcriptional regulator 216560 1197975 BMEII0204 Brucella melitensis bv. 1 str. 16M GntR family transcriptional regulator NP_541181.1 216078 R 224914 CDS NP_541182.1 17988549 1197976 complement(216784..217914) 1 NC_003318.1 peptide ABC transporter ATP-binding protein 217914 1197976 BMEII0205 Brucella melitensis bv. 1 str. 16M peptide ABC transporter ATP-binding protein NP_541182.1 216784 R 224914 CDS NP_541183.1 17988550 1197977 complement(217785..218783) 1 NC_003318.1 peptide ABC transporter ATP-binding protein 218783 1197977 BMEII0206 Brucella melitensis bv. 1 str. 16M peptide ABC transporter ATP-binding protein NP_541183.1 217785 R 224914 CDS NP_541184.1 17988551 1197978 complement(218786..219319) 1 NC_003318.1 peptide ABC transporter permease 219319 1197978 BMEII0207 Brucella melitensis bv. 1 str. 16M peptide ABC transporter permease NP_541184.1 218786 R 224914 CDS NP_541185.1 17988552 1197979 complement(219190..219615) 1 NC_003318.1 peptide ABC transporter permease 219615 1197979 BMEII0208 Brucella melitensis bv. 1 str. 16M peptide ABC transporter permease NP_541185.1 219190 R 224914 CDS NP_541186.1 17988553 1197980 complement(219668..220615) 1 NC_003318.1 peptide ABC transporter permease 220615 1197980 BMEII0209 Brucella melitensis bv. 1 str. 16M peptide ABC transporter permease NP_541186.1 219668 R 224914 CDS NP_541187.1 17988554 1197981 complement(220769..222280) 1 NC_003318.1 periplasmic dipeptide transport protein precursor 222280 1197981 BMEII0210 Brucella melitensis bv. 1 str. 16M periplasmic dipeptide transport protein precursor NP_541187.1 220769 R 224914 CDS NP_541188.1 17988555 1197982 complement(222336..223289) 1 NC_003318.1 penicillin acylase 223289 1197982 BMEII0211 Brucella melitensis bv. 1 str. 16M penicillin acylase NP_541188.1 222336 R 224914 CDS NP_541189.1 17988556 1197983 complement(223223..224620) 1 NC_003318.1 penicillin acylase 224620 1197983 BMEII0212 Brucella melitensis bv. 1 str. 16M penicillin acylase NP_541189.1 223223 R 224914 CDS NP_541190.1 17988557 1197984 complement(224946..226091) 1 NC_003318.1 acyl-CoA dehydrogenase 226091 1197984 BMEII0213 Brucella melitensis bv. 1 str. 16M acyl-CoA dehydrogenase NP_541190.1 224946 R 224914 CDS NP_541191.1 17988558 1197985 226160..227053 1 NC_003318.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 227053 1197985 BMEII0214 Brucella melitensis bv. 1 str. 16M enoyl-CoA hydratase NP_541191.1 226160 D 224914 CDS NP_541192.1 17988559 1197986 227055..228557 1 NC_003318.1 converts 3-hydroxyadipyl-CoA to beta-ketoadipyl-CoA in phenylacetate degradation; 3-hydroxyacyl-CoA dehydrogenase 228557 1197986 BMEII0215 Brucella melitensis bv. 1 str. 16M 3-hydroxyacyl-CoA dehydrogenase NP_541192.1 227055 D 224914 CDS NP_541193.1 17988560 1197987 228572..230749 1 NC_003318.1 2-oxoisovalerate dehydrogenase subunit beta 230749 1197987 BMEII0216 Brucella melitensis bv. 1 str. 16M 2-oxoisovalerate dehydrogenase subunit beta NP_541193.1 228572 D 224914 CDS NP_541194.1 17988561 1197988 230779..232398 1 NC_003318.1 periplasmic dipeptide transport protein precursor 232398 1197988 BMEII0217 Brucella melitensis bv. 1 str. 16M periplasmic dipeptide transport protein precursor NP_541194.1 230779 D 224914 CDS NP_541195.1 17988562 1197989 complement(232482..233768) 1 NC_003318.1 Catalyzes the transfer of acetyl from acetyldihydrolipoamide to coenzyme A to form acetyl CoA; branched-chain alpha-keto acid dehydrogenase subunit E2 233768 1197989 BMEII0218 Brucella melitensis bv. 1 str. 16M branched-chain alpha-keto acid dehydrogenase subunit E2 NP_541195.1 232482 R 224914 CDS NP_541196.1 17988563 1197990 complement(233828..234754) 1 NC_003318.1 transcriptional regulator 234754 1197990 BMEII0219 Brucella melitensis bv. 1 str. 16M transcriptional regulator NP_541196.1 233828 R 224914 CDS NP_541197.1 17988564 1197991 234759..235823 1 NC_003318.1 oligopeptide transport system permease OPPB 235823 1197991 BMEII0220 Brucella melitensis bv. 1 str. 16M oligopeptide transport system permease OPPB NP_541197.1 234759 D 224914 CDS NP_541198.1 17988565 1197992 235835..236491 1 NC_003318.1 peptide ABC transporter permease 236491 1197992 BMEII0221 Brucella melitensis bv. 1 str. 16M peptide ABC transporter permease NP_541198.1 235835 D 224914 CDS NP_541199.1 17988566 1197993 236504..237541 1 NC_003318.1 oligopeptide transport ATP-binding protein OPPD 237541 1197993 BMEII0222 Brucella melitensis bv. 1 str. 16M oligopeptide transport ATP-binding protein OPPD NP_541199.1 236504 D 224914 CDS NP_541200.1 17988567 1197994 237333..238538 1 NC_003318.1 oligopeptide transport ATP-binding protein OPPF 238538 1197994 BMEII0223 Brucella melitensis bv. 1 str. 16M oligopeptide transport ATP-binding protein OPPF NP_541200.1 237333 D 224914 CDS NP_541201.1 17988568 1197995 238492..239856 1 NC_003318.1 formyl-coenzyme A transferase 239856 1197995 BMEII0224 Brucella melitensis bv. 1 str. 16M formyl-coenzyme A transferase NP_541201.1 238492 D 224914 CDS NP_541202.1 17988569 1197996 239847..241268 1 NC_003318.1 6-oxohexanoate dehydrogenase 241268 1197996 BMEII0225 Brucella melitensis bv. 1 str. 16M 6-oxohexanoate dehydrogenase NP_541202.1 239847 D 224914 CDS NP_541203.1 17988570 1197997 complement(241507..242235) 1 NC_003318.1 NTA operon transcriptional regulator 242235 1197997 BMEII0226 Brucella melitensis bv. 1 str. 16M NTA operon transcriptional regulator NP_541203.1 241507 R 224914 CDS NP_541204.1 17988571 1197998 242480..242761 1 NC_003318.1 transposase 242761 1197998 BMEII0227 Brucella melitensis bv. 1 str. 16M transposase NP_541204.1 242480 D 224914 CDS NP_541205.1 17988572 1197999 242758..243687 1 NC_003318.1 transposase 243687 1197999 BMEII0228 Brucella melitensis bv. 1 str. 16M transposase NP_541205.1 242758 D 224914 CDS NP_541206.1 17988573 1198000 244358..244681 1 NC_003318.1 hypothetical protein 244681 1198000 BMEII0229 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541206.1 244358 D 224914 CDS NP_541207.1 17988574 1198001 244704..245360 1 NC_003318.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A 245360 1198001 BMEII0230 Brucella melitensis bv. 1 str. 16M methionine sulfoxide reductase A NP_541207.1 244704 D 224914 CDS NP_541208.1 17988575 1198002 complement(245373..245579) 1 NC_003318.1 hypothetical protein 245579 1198002 BMEII0231 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541208.1 245373 R 224914 CDS NP_541209.1 17988576 1198003 complement(245690..246316) 1 NC_003318.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 246316 upp 1198003 upp Brucella melitensis bv. 1 str. 16M uracil phosphoribosyltransferase NP_541209.1 245690 R 224914 CDS NP_541210.1 17988577 1198004 246627..247436 1 NC_003318.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase 247436 ubiE 1198004 ubiE Brucella melitensis bv. 1 str. 16M ubiquinone/menaquinone biosynthesis methyltransferase NP_541210.1 246627 D 224914 CDS NP_541211.1 17988578 1198005 247470..249068 1 NC_003318.1 ubiquinone biosynthesis protein AARF 249068 1198005 BMEII0234 Brucella melitensis bv. 1 str. 16M ubiquinone biosynthesis protein AARF NP_541211.1 247470 D 224914 CDS NP_541212.1 17988579 1198006 249105..250319 1 NC_003318.1 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase 250319 1198006 BMEII0235 Brucella melitensis bv. 1 str. 16M bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase NP_541212.1 249105 D 224914 CDS NP_541213.1 17988580 1198007 complement(250316..251893) 1 NC_003318.1 peptide chain release factor 3 251893 1198007 BMEII0236 Brucella melitensis bv. 1 str. 16M peptide chain release factor 3 NP_541213.1 250316 R 224914 CDS NP_541214.1 17988581 1198008 complement(251883..252020) 1 NC_003318.1 hypothetical protein 252020 1198008 BMEII0237 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541214.1 251883 R 224914 CDS NP_541215.1 17988582 1198009 complement(252054..252617) 1 NC_003318.1 HdeD protein 252617 1198009 BMEII0238 Brucella melitensis bv. 1 str. 16M HdeD protein NP_541215.1 252054 R 224914 CDS NP_541216.1 17988583 1198010 252771..254249 1 NC_003318.1 cardiolipin synthetase 254249 1198010 BMEII0239 Brucella melitensis bv. 1 str. 16M cardiolipin synthetase NP_541216.1 252771 D 224914 CDS NP_541217.1 17988584 1198011 complement(254259..255116) 1 NC_003318.1 dioxygenase 255116 1198011 BMEII0240 Brucella melitensis bv. 1 str. 16M dioxygenase NP_541217.1 254259 R 224914 CDS NP_541218.1 17988585 1198012 complement(255271..255945) 1 NC_003318.1 coniferyl-aldehyde dehydrogenase 255945 1198012 BMEII0241 Brucella melitensis bv. 1 str. 16M coniferyl-aldehyde dehydrogenase NP_541218.1 255271 R 224914 CDS NP_541219.1 17988586 1198013 complement(255731..256417) 1 NC_003318.1 aldehyde dehydrogenase 256417 1198013 BMEII0242 Brucella melitensis bv. 1 str. 16M aldehyde dehydrogenase NP_541219.1 255731 R 224914 CDS NP_541220.1 17988587 1198014 complement(256676..257230) 1 NC_003318.1 hypothetical protein 257230 1198014 BMEII0243 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541220.1 256676 R 224914 CDS NP_541221.1 17988588 1198015 257261..257479 1 NC_003318.1 hypothetical protein 257479 1198015 BMEII0244 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541221.1 257261 D 224914 CDS NP_541222.1 17988589 1198016 complement(257596..258042) 1 NC_003318.1 universal stress protein 258042 1198016 BMEII0245 Brucella melitensis bv. 1 str. 16M universal stress protein NP_541222.1 257596 R 224914 CDS NP_541223.1 17988590 1198017 complement(258239..258922) 1 NC_003318.1 nitroreductase 258922 1198017 BMEII0246 Brucella melitensis bv. 1 str. 16M nitroreductase NP_541223.1 258239 R 224914 CDS NP_541224.1 17988591 1198018 complement(259372..261123) 1 NC_003318.1 exoenzymes regulatory protein AEPA precursor 261123 1198018 BMEII0247 Brucella melitensis bv. 1 str. 16M exoenzymes regulatory protein AEPA precursor NP_541224.1 259372 R 224914 CDS NP_541225.1 17988592 1198019 complement(261543..262196) 1 NC_003318.1 catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 262196 1198019 BMEII0248 Brucella melitensis bv. 1 str. 16M phosphoglyceromutase NP_541225.1 261543 R 224914 CDS NP_541226.1 17988593 1198020 complement(262200..263039) 1 NC_003318.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 263039 1198020 BMEII0249 Brucella melitensis bv. 1 str. 16M dihydrodipicolinate reductase NP_541226.1 262200 R 224914 CDS NP_541227.1 17988594 1198021 complement(263036..264871) 1 NC_003318.1 ABC transporter ATP-binding protein 264871 1198021 BMEII0250 Brucella melitensis bv. 1 str. 16M ABC transporter ATP-binding protein NP_541227.1 263036 R 224914 CDS NP_541228.1 17988595 1198022 complement(265092..266138) 1 NC_003318.1 catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate; glucokinase 266138 glk 1198022 glk Brucella melitensis bv. 1 str. 16M glucokinase NP_541228.1 265092 R 224914 CDS NP_541229.1 17988596 1198023 complement(266204..266581) 1 NC_003318.1 catalyzes the formation of methylglyoxal from glycerone phosphate; methylglyoxal synthase 266581 mgsA 1198023 mgsA Brucella melitensis bv. 1 str. 16M methylglyoxal synthase NP_541229.1 266204 R 224914 CDS NP_541230.1 17988597 1198024 complement(266734..267756) 1 NC_003318.1 D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm; penicillin-insensitive murein endopeptidase 267756 mepA 1198024 mepA Brucella melitensis bv. 1 str. 16M penicillin-insensitive murein endopeptidase NP_541230.1 266734 R 224914 CDS NP_541231.1 17988598 1198025 complement(267757..268668) 1 NC_003318.1 nucleoside-diphosphate-sugar epimerase 268668 1198025 BMEII0254 Brucella melitensis bv. 1 str. 16M nucleoside-diphosphate-sugar epimerase NP_541231.1 267757 R 224914 CDS NP_541232.1 17988599 1198026 complement(268628..269842) 1 NC_003318.1 (Fe-S)-binding protein 269842 1198026 BMEII0255 Brucella melitensis bv. 1 str. 16M (Fe-S)-binding protein NP_541232.1 268628 R 224914 CDS NP_541233.1 17988600 1198027 complement(269805..270497) 1 NC_003318.1 glutathione S-transferase 270497 1198027 BMEII0256 Brucella melitensis bv. 1 str. 16M glutathione S-transferase NP_541233.1 269805 R 224914 CDS NP_541234.1 17988601 1198028 270545..270748 1 NC_003318.1 hypothetical protein 270748 1198028 BMEII0257 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541234.1 270545 D 224914 CDS NP_541235.1 17988602 1198029 270753..271559 1 NC_003318.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; undecaprenyl pyrophosphate phosphatase 271559 uppP 1198029 uppP Brucella melitensis bv. 1 str. 16M undecaprenyl pyrophosphate phosphatase NP_541235.1 270753 D 224914 CDS NP_541236.1 17988603 1198030 complement(271660..272646) 1 NC_003318.1 NADH-ubiquinone oxidoreductase 39 kd subunit 272646 1198030 BMEII0259 Brucella melitensis bv. 1 str. 16M NADH-ubiquinone oxidoreductase 39 kd subunit NP_541236.1 271660 R 224914 CDS NP_541237.1 17988604 1198031 272810..274618 1 NC_003318.1 binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 274618 1198031 BMEII0260 Brucella melitensis bv. 1 str. 16M GTP-binding protein LepA NP_541237.1 272810 D 224914 CDS NP_541238.1 17988605 1198032 complement(274867..275217) 1 NC_003318.1 cytoplasmic protein 275217 1198032 BMEII0261 Brucella melitensis bv. 1 str. 16M cytoplasmic protein NP_541238.1 274867 R 224914 CDS NP_541239.1 17988606 1198033 275257..275562 1 NC_003318.1 hypothetical protein 275562 1198033 BMEII0262 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541239.1 275257 D 224914 CDS NP_541240.1 17988607 1198034 complement(275799..276821) 1 NC_003318.1 hypothetical protein 276821 1198034 BMEII0263 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541240.1 275799 R 224914 CDS NP_541241.1 17988608 1198035 277089..277652 1 NC_003318.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 277652 def 1198035 def Brucella melitensis bv. 1 str. 16M peptide deformylase NP_541241.1 277089 D 224914 CDS NP_541242.1 17988609 1198036 277652..278572 1 NC_003318.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 278572 fmt 1198036 fmt Brucella melitensis bv. 1 str. 16M methionyl-tRNA formyltransferase NP_541242.1 277652 D 224914 CDS NP_541243.1 17988610 1198037 278576..279331 1 NC_003318.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 279331 truA 1198037 truA Brucella melitensis bv. 1 str. 16M tRNA pseudouridine synthase A NP_541243.1 278576 D 224914 CDS NP_541244.1 17988611 1198038 complement(279506..280063) 1 NC_003318.1 hypothetical protein 280063 1198038 BMEII0267 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541244.1 279506 R 224914 CDS NP_541245.1 17988612 1198039 complement(280174..281361) 1 NC_003318.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.; succinyl-diaminopimelate desuccinylase 281361 1198039 BMEII0268 Brucella melitensis bv. 1 str. 16M succinyl-diaminopimelate desuccinylase NP_541245.1 280174 R 224914 CDS NP_541246.1 17988613 1198040 281646..282200 1 NC_003318.1 hypothetical protein 282200 1198040 BMEII0269 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541246.1 281646 D 224914 CDS NP_541247.1 17988614 1198041 complement(282344..283198) 1 NC_003318.1 catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 283198 dapD 1198041 dapD Brucella melitensis bv. 1 str. 16M 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase NP_541247.1 282344 R 224914 CDS NP_541248.1 17988615 1198042 283417..284247 1 NC_003318.1 3-isopropylmalate dehydrogenase 284247 1198042 BMEII0271 Brucella melitensis bv. 1 str. 16M 3-isopropylmalate dehydrogenase NP_541248.1 283417 D 224914 CDS NP_541249.1 17988616 1198043 complement(284309..285013) 1 NC_003318.1 phosphoglycolate phosphatase 285013 1198043 BMEII0272 Brucella melitensis bv. 1 str. 16M phosphoglycolate phosphatase NP_541249.1 284309 R 224914 CDS NP_541250.1 17988617 1198044 complement(285087..286049) 1 NC_003318.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase 286049 1198044 BMEII0273 Brucella melitensis bv. 1 str. 16M acetylglutamate kinase NP_541250.1 285087 R 224914 CDS NP_541251.1 17988618 1198045 complement(286148..286873) 1 NC_003318.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 286873 engB 1198045 engB Brucella melitensis bv. 1 str. 16M ribosome biogenesis GTP-binding protein YsxC NP_541251.1 286148 R 224914 CDS NP_541252.2 161511178 1198046 complement(286993..288825) 1 NC_003318.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; inner membrane protein translocase component YidC 288825 1198046 BMEII0275 Brucella melitensis bv. 1 str. 16M inner membrane protein translocase component YidC NP_541252.2 286993 R 224914 CDS NP_541253.1 17988620 1198047 complement(288815..289240) 1 NC_003318.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 289240 rnpA 1198047 rnpA Brucella melitensis bv. 1 str. 16M ribonuclease P NP_541253.1 288815 R 224914 CDS NP_541254.1 17988621 1198048 complement(289290..289424) 1 NC_003318.1 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 289424 rpmH 1198048 rpmH Brucella melitensis bv. 1 str. 16M 50S ribosomal protein L34 NP_541254.1 289290 R 224914 CDS NP_541255.1 17988622 1198049 complement(289425..289649) 1 NC_003318.1 hypothetical protein 289649 1198049 BMEII0277 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541255.1 289425 R 224914 CDS NP_541256.1 17988623 1198050 289690..290076 1 NC_003318.1 translation initiation inhibitor 290076 1198050 BMEII0278 Brucella melitensis bv. 1 str. 16M translation initiation inhibitor NP_541256.1 289690 D 224914 CDS NP_541257.1 17988624 1198051 complement(290130..291125) 1 NC_003318.1 hypothetical protein 291125 1198051 BMEII0279 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541257.1 290130 R 224914 CDS NP_541258.1 17988625 1198052 complement(291591..292982) 1 NC_003318.1 multidrug resistance protein B 292982 1198052 BMEII0280 Brucella melitensis bv. 1 str. 16M multidrug resistance protein B NP_541258.1 291591 R 224914 CDS NP_541259.1 17988626 1198053 293310..294026 1 NC_003318.1 GntR family transcriptional regulator 294026 1198053 BMEII0281 Brucella melitensis bv. 1 str. 16M GntR family transcriptional regulator NP_541259.1 293310 D 224914 CDS NP_541260.1 17988627 1198054 293887..295497 1 NC_003318.1 aldehyde dehydrogenase 295497 1198054 BMEII0282 Brucella melitensis bv. 1 str. 16M aldehyde dehydrogenase NP_541260.1 293887 D 224914 CDS NP_541261.1 17988628 1198055 295502..296290 1 NC_003318.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 296290 fabG 1198055 fabG Brucella melitensis bv. 1 str. 16M 3-ketoacyl-ACP reductase NP_541261.1 295502 D 224914 CDS NP_541262.1 17988629 1198056 296271..297791 1 NC_003318.1 periplasmic dipeptide transport protein precursor 297791 1198056 BMEII0284 Brucella melitensis bv. 1 str. 16M periplasmic dipeptide transport protein precursor NP_541262.1 296271 D 224914 CDS NP_541263.1 17988630 1198057 297889..298842 1 NC_003318.1 peptide ABC transporter permease 298842 1198057 BMEII0285 Brucella melitensis bv. 1 str. 16M peptide ABC transporter permease NP_541263.1 297889 D 224914 CDS NP_541264.1 17988631 1198058 298905..299699 1 NC_003318.1 peptide ABC transporter permease 299699 1198058 BMEII0286 Brucella melitensis bv. 1 str. 16M peptide ABC transporter permease NP_541264.1 298905 D 224914 CDS NP_541265.1 17988632 1198059 299696..300721 1 NC_003318.1 peptide ABC transporter ATP-binding protein 300721 1198059 BMEII0287 Brucella melitensis bv. 1 str. 16M peptide ABC transporter ATP-binding protein NP_541265.1 299696 D 224914 CDS NP_541266.1 17988633 1198060 300718..301566 1 NC_003318.1 peptide ABC transporter ATP-binding protein 301566 1198060 BMEII0288 Brucella melitensis bv. 1 str. 16M peptide ABC transporter ATP-binding protein NP_541266.1 300718 D 224914 CDS NP_541267.1 17988634 1198061 301580..302968 1 NC_003318.1 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia; amidase 302968 1198061 BMEII0289 Brucella melitensis bv. 1 str. 16M amidase NP_541267.1 301580 D 224914 CDS NP_541268.1 17988635 1198062 complement(303044..303862) 1 NC_003318.1 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 303862 1198062 BMEII0290 Brucella melitensis bv. 1 str. 16M DNA polymerase III subunit epsilon NP_541268.1 303044 R 224914 CDS NP_541269.1 17988636 1198063 304198..305430 1 NC_003318.1 catalyzed the formation of 2-ketoglutarate from 2-hydroxyglutarate; hydroxyglutarate oxidase 305430 1198063 BMEII0291 Brucella melitensis bv. 1 str. 16M hydroxyglutarate oxidase NP_541269.1 304198 D 224914 CDS NP_541270.1 17988637 1198064 305605..306651 1 NC_003318.1 response regulator protein 306651 1198064 BMEII0292 Brucella melitensis bv. 1 str. 16M response regulator protein NP_541270.1 305605 D 224914 CDS NP_541271.1 17988638 1198065 307466..308215 1 NC_003318.1 hypothetical protein 308215 1198065 BMEII0293 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541271.1 307466 D 224914 CDS NP_541272.1 17988639 1198066 308319..308924 1 NC_003318.1 glutathione S-transferase 308924 1198066 BMEII0294 Brucella melitensis bv. 1 str. 16M glutathione S-transferase NP_541272.1 308319 D 224914 CDS NP_541273.1 17988640 1198067 308981..309493 1 NC_003318.1 biphenyl-2,3-diol 1,2-dioxygenase III 309493 1198067 BMEII0295 Brucella melitensis bv. 1 str. 16M biphenyl-2,3-diol 1,2-dioxygenase III NP_541273.1 308981 D 224914 CDS NP_541274.1 17988641 1198068 309712..310053 1 NC_003318.1 hypothetical protein 310053 1198068 BMEII0296 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541274.1 309712 D 224914 CDS NP_541275.1 17988642 1198069 310231..312180 1 NC_003318.1 outer membrane protein NosA precursor 312180 1198069 BMEII0297 Brucella melitensis bv. 1 str. 16M outer membrane protein NosA precursor NP_541275.1 310231 D 224914 CDS NP_541276.1 17988643 1198070 312348..313529 1 NC_003318.1 hypothetical protein 313529 1198070 BMEII0298 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541276.1 312348 D 224914 CDS NP_541277.1 17988644 1198071 complement(313623..314417) 1 NC_003318.1 IclR family transcriptional regulator 314417 1198071 BMEII0299 Brucella melitensis bv. 1 str. 16M IclR family transcriptional regulator NP_541277.1 313623 R 224914 CDS NP_541278.1 17988645 1198072 315575..317329 1 NC_003318.1 ribose ABC transporter ATP-binding protein 317329 1198072 BMEII0300 Brucella melitensis bv. 1 str. 16M ribose ABC transporter ATP-binding protein NP_541278.1 315575 D 224914 CDS NP_541279.1 17988646 1198073 317341..318288 1 NC_003318.1 ribose ABC transporter permease 318288 1198073 BMEII0301 Brucella melitensis bv. 1 str. 16M ribose ABC transporter permease NP_541279.1 317341 D 224914 CDS NP_541280.1 17988647 1198074 318384..319238 1 NC_003318.1 ribose ABC transporter permease 319238 1198074 BMEII0302 Brucella melitensis bv. 1 str. 16M ribose ABC transporter permease NP_541280.1 318384 D 224914 CDS NP_541281.1 17988648 1198075 319238..319657 1 NC_003318.1 translation initiation inhibitor 319657 1198075 BMEII0303 Brucella melitensis bv. 1 str. 16M translation initiation inhibitor NP_541281.1 319238 D 224914 CDS NP_541282.1 17988649 1198076 complement(319865..320527) 1 NC_003318.1 in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme; sulfite oxidase subunit YedZ 320527 1198076 BMEII0304 Brucella melitensis bv. 1 str. 16M sulfite oxidase subunit YedZ NP_541282.1 319865 R 224914 CDS NP_541283.1 17988650 1198077 complement(320529..321488) 1 NC_003318.1 in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ; sulfite oxidase subunit YedY 321488 1198077 BMEII0305 Brucella melitensis bv. 1 str. 16M sulfite oxidase subunit YedY NP_541283.1 320529 R 224914 CDS NP_541284.1 17988651 1198078 322091..322777 1 NC_003318.1 carboxylesterase 322777 1198078 BMEII0306 Brucella melitensis bv. 1 str. 16M carboxylesterase NP_541284.1 322091 D 224914 CDS NP_541285.1 17988652 1198079 complement(322918..323892) 1 NC_003318.1 vegetatible incompatibility protein HET-E-1 323892 1198079 BMEII0307 Brucella melitensis bv. 1 str. 16M vegetatible incompatibility protein HET-E-1 NP_541285.1 322918 R 224914 CDS NP_541286.1 17988653 1198080 complement(324011..325129) 1 NC_003318.1 zinc transporter 325129 1198080 BMEII0308 Brucella melitensis bv. 1 str. 16M zinc transporter NP_541286.1 324011 R 224914 CDS NP_541287.1 17988654 1198081 complement(325365..326198) 1 NC_003318.1 creatininase 326198 1198081 BMEII0309 Brucella melitensis bv. 1 str. 16M creatininase NP_541287.1 325365 R 224914 CDS NP_541288.1 17988655 1198082 326308..326541 1 NC_003318.1 MarR family transcriptional regulator 326541 1198082 BMEII0310 Brucella melitensis bv. 1 str. 16M MarR family transcriptional regulator NP_541288.1 326308 D 224914 CDS NP_541289.1 17988656 1198083 326548..326805 1 NC_003318.1 MarR family transcriptional regulator 326805 1198083 BMEII0311 Brucella melitensis bv. 1 str. 16M MarR family transcriptional regulator NP_541289.1 326548 D 224914 CDS NP_541290.1 17988657 1198084 326895..327971 1 NC_003318.1 ribose operon repressor 327971 1198084 BMEII0312 Brucella melitensis bv. 1 str. 16M ribose operon repressor NP_541290.1 326895 D 224914 CDS NP_541291.1 17988658 1198085 328057..329031 1 NC_003318.1 Catalyzes the reduction of hydroxypyruvate to form D-glycerate, using NADH as an electron donor; glycerate dehydrogenase 329031 1198085 BMEII0313 Brucella melitensis bv. 1 str. 16M glycerate dehydrogenase NP_541291.1 328057 D 224914 CDS NP_541292.1 17988659 1198086 complement(329012..329914) 1 NC_003318.1 anthranilate synthase component II 329914 1198086 BMEII0314 Brucella melitensis bv. 1 str. 16M anthranilate synthase component II NP_541292.1 329012 R 224914 CDS NP_541293.1 17988660 1198087 329905..330156 1 NC_003318.1 hypothetical protein 330156 1198087 BMEII0315 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541293.1 329905 D 224914 CDS NP_541294.1 17988661 1198088 330149..330898 1 NC_003318.1 2-deoxy-D-gluconate 3-dehydrogenase 330898 1198088 BMEII0316 Brucella melitensis bv. 1 str. 16M 2-deoxy-D-gluconate 3-dehydrogenase NP_541294.1 330149 D 224914 CDS NP_541295.1 17988662 1198089 331264..333561 1 NC_003318.1 diguanylate cyclase/phosphodiesterase 333561 1198089 BMEII0317 Brucella melitensis bv. 1 str. 16M diguanylate cyclase/phosphodiesterase NP_541295.1 331264 D 224914 CDS NP_541296.1 17988663 1198090 333814..334584 1 NC_003318.1 6-aminohexanoate-dimer hydrolase 334584 1198090 BMEII0318 Brucella melitensis bv. 1 str. 16M 6-aminohexanoate-dimer hydrolase NP_541296.1 333814 D 224914 CDS NP_541297.1 17988664 1198091 334642..335031 1 NC_003318.1 6-aminohexanoate-dimer hydrolase 335031 1198091 BMEII0319 Brucella melitensis bv. 1 str. 16M 6-aminohexanoate-dimer hydrolase NP_541297.1 334642 D 224914 CDS NP_541298.1 17988665 1198092 335339..335644 1 NC_003318.1 hypothetical protein 335644 1198092 BMEII0320 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541298.1 335339 D 224914 CDS NP_541299.1 17988666 1198093 335641..336048 1 NC_003318.1 hypothetical protein 336048 1198093 BMEII0321 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541299.1 335641 D 224914 CDS NP_541300.1 17988667 1198094 336237..336476 1 NC_003318.1 cytochrome c oxidase polypeptide IV 336476 1198094 BMEII0322 Brucella melitensis bv. 1 str. 16M cytochrome c oxidase polypeptide IV NP_541300.1 336237 D 224914 CDS NP_541301.1 17988668 1198095 336700..337989 1 NC_003318.1 NAD(P) transhydrogenase subunit alpha 337989 1198095 BMEII0323 Brucella melitensis bv. 1 str. 16M NAD(P) transhydrogenase subunit alpha NP_541301.1 336700 D 224914 CDS NP_541302.1 17988669 1198096 338046..338408 1 NC_003318.1 NAD(P) transhydrogenase subunit alpha 338408 1198096 BMEII0324 Brucella melitensis bv. 1 str. 16M NAD(P) transhydrogenase subunit alpha NP_541302.1 338046 D 224914 CDS NP_541303.1 17988670 1198097 338421..339821 1 NC_003318.1 NAD(P) transhydrogenase subunit beta 339821 1198097 BMEII0325 Brucella melitensis bv. 1 str. 16M NAD(P) transhydrogenase subunit beta NP_541303.1 338421 D 224914 CDS NP_541304.1 17988671 1198098 complement(339915..341219) 1 NC_003318.1 homoserine dehydrogenase 341219 1198098 BMEII0326 Brucella melitensis bv. 1 str. 16M homoserine dehydrogenase NP_541304.1 339915 R 224914 CDS NP_541305.1 17988672 1198099 341304..342098 1 NC_003318.1 phosphoglycolate phosphatase 342098 1198099 BMEII0327 Brucella melitensis bv. 1 str. 16M phosphoglycolate phosphatase NP_541305.1 341304 D 224914 CDS NP_541306.1 17988673 1198100 342173..342649 1 NC_003318.1 nodulation protein N 342649 1198100 BMEII0328 Brucella melitensis bv. 1 str. 16M nodulation protein N NP_541306.1 342173 D 224914 CDS NP_541307.1 17988674 1198101 complement(342724..343164) 1 NC_003318.1 hypothetical protein 343164 1198101 BMEII0329 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541307.1 342724 R 224914 CDS NP_541308.1 17988675 1198102 complement(343369..343623) 1 NC_003318.1 hypothetical protein 343623 1198102 BMEII0330 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541308.1 343369 R 224914 CDS NP_541309.1 17988676 1198103 complement(343620..343919) 1 NC_003318.1 cytoplasmic protein 343919 1198103 BMEII0331 Brucella melitensis bv. 1 str. 16M cytoplasmic protein NP_541309.1 343620 R 224914 CDS NP_541310.1 17988677 1198104 344272..344499 1 NC_003318.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 344499 rpsU 1198104 rpsU Brucella melitensis bv. 1 str. 16M 30S ribosomal protein S21 NP_541310.1 344272 D 224914 CDS NP_541311.1 17988678 1198105 complement(344768..345031) 1 NC_003318.1 hypothetical protein 345031 1198105 BMEII0333 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541311.1 344768 R 224914 CDS NP_541312.1 17988679 1198106 345143..345910 1 NC_003318.1 TPR repeat-containing protein 345910 1198106 BMEII0334 Brucella melitensis bv. 1 str. 16M TPR repeat-containing protein NP_541312.1 345143 D 224914 CDS NP_541313.1 17988680 1198107 346002..346409 1 NC_003318.1 hypothetical protein 346409 1198107 BMEII0335 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541313.1 346002 D 224914 CDS NP_541314.1 17988681 1198108 complement(346422..347114) 1 NC_003318.1 ABC transporter permease 347114 1198108 BMEII0336 Brucella melitensis bv. 1 str. 16M ABC transporter permease NP_541314.1 346422 R 224914 CDS NP_541315.1 17988682 1198109 complement(347068..348177) 1 NC_003318.1 ABC transporter ATP-binding protein 348177 1198109 BMEII0337 Brucella melitensis bv. 1 str. 16M ABC transporter ATP-binding protein NP_541315.1 347068 R 224914 CDS NP_541316.1 17988683 1198110 complement(348591..349427) 1 NC_003318.1 ABC transporter substrate-binding protein 349427 1198110 BMEII0338 Brucella melitensis bv. 1 str. 16M ABC transporter substrate-binding protein NP_541316.1 348591 R 224914 CDS NP_541317.1 17988684 1198111 complement(349661..351259) 1 NC_003318.1 alcohol dehydrogenase 351259 1198111 BMEII0339 Brucella melitensis bv. 1 str. 16M alcohol dehydrogenase NP_541317.1 349661 R 224914 CDS NP_541318.1 17988685 1198112 complement(351323..352318) 1 NC_003318.1 high-affinity branched-chain amino acid transport system permease LIVM 352318 1198112 BMEII0340 Brucella melitensis bv. 1 str. 16M high-affinity branched-chain amino acid transport system permease LIVM NP_541318.1 351323 R 224914 CDS NP_541319.1 17988686 1198113 complement(352320..353207) 1 NC_003318.1 high-affinity branched-chain amino acid transport system permease livH 353207 1198113 BMEII0341 Brucella melitensis bv. 1 str. 16M high-affinity branched-chain amino acid transport system permease livH NP_541319.1 352320 R 224914 CDS NP_541320.1 17988687 1198114 complement(353212..354036) 1 NC_003318.1 high-affinity branched-chain amino acid transport ATP-binding protein LIVF 354036 1198114 BMEII0342 Brucella melitensis bv. 1 str. 16M high-affinity branched-chain amino acid transport ATP-binding protein LIVF NP_541320.1 353212 R 224914 CDS NP_541321.1 17988688 1198115 complement(353930..354748) 1 NC_003318.1 high-affinity branched-chain amino acid transport ATP-binding protein LIVG 354748 1198115 BMEII0343 Brucella melitensis bv. 1 str. 16M high-affinity branched-chain amino acid transport ATP-binding protein LIVG NP_541321.1 353930 R 224914 CDS NP_541322.1 17988689 1198116 complement(354758..355963) 1 NC_003318.1 branched chain amino acid ABC transporter amino acid-binding protein 355963 1198116 BMEII0344 Brucella melitensis bv. 1 str. 16M branched chain amino acid ABC transporter amino acid-binding protein NP_541322.1 354758 R 224914 CDS NP_541323.1 17988690 1198117 356192..357142 1 NC_003318.1 LysR family transcriptional regulator 357142 1198117 BMEII0345 Brucella melitensis bv. 1 str. 16M LysR family transcriptional regulator NP_541323.1 356192 D 224914 CDS NP_541324.1 17988691 1198118 complement(357358..357798) 1 NC_003318.1 AsnC family transcriptional regulator 357798 1198118 BMEII0346 Brucella melitensis bv. 1 str. 16M AsnC family transcriptional regulator NP_541324.1 357358 R 224914 CDS NP_541325.1 17988692 1198119 357971..359935 1 NC_003318.1 membrane protein related to metalloendopeptidase 359935 1198119 BMEII0347 Brucella melitensis bv. 1 str. 16M membrane protein related to metalloendopeptidase NP_541325.1 357971 D 224914 CDS NP_541326.1 17988693 1198120 359851..361122 1 NC_003318.1 4-aminobutyrate aminotransferase 361122 1198120 BMEII0348 Brucella melitensis bv. 1 str. 16M 4-aminobutyrate aminotransferase NP_541326.1 359851 D 224914 CDS NP_541327.1 17988694 1198121 361250..362245 1 NC_003318.1 general L-amino acid-binding periplasmic protein AAPJ precursor 362245 1198121 BMEII0349 Brucella melitensis bv. 1 str. 16M general L-amino acid-binding periplasmic protein AAPJ precursor NP_541327.1 361250 D 224914 CDS NP_541328.1 17988695 1198122 complement(362276..363832) 1 NC_003318.1 intracellular enzymes acting on low molecular weight D-amino acid amides, esters and oligopeptides containing D-amino acids; these proteases release the N-terminal D-amino acid from a peptide, and show higher affinity for D-Ala, D-Ser or D-Thr; no preference for the stereochemistry of the second amino acid; D-aminopeptidase 363832 1198122 BMEII0350 Brucella melitensis bv. 1 str. 16M D-aminopeptidase NP_541328.1 362276 R 224914 CDS NP_541329.1 17988696 1198123 364239..365933 1 NC_003318.1 catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive; also known as acetolactate synthase large subunit; thiamine pyrophosphate protein 365933 1198123 BMEII0351 Brucella melitensis bv. 1 str. 16M thiamine pyrophosphate protein NP_541329.1 364239 D 224914 CDS NP_541330.1 17988697 1198124 complement(365946..366665) 1 NC_003318.1 GntR family transcriptional regulator 366665 1198124 BMEII0352 Brucella melitensis bv. 1 str. 16M GntR family transcriptional regulator NP_541330.1 365946 R 224914 CDS NP_541331.1 17988698 1198125 complement(366696..366989) 1 NC_003318.1 sugar transport system permease 366989 1198125 BMEII0353 Brucella melitensis bv. 1 str. 16M sugar transport system permease NP_541331.1 366696 R 224914 CDS NP_541332.1 17988699 1198126 367238..368251 1 NC_003318.1 sugar transporter 368251 1198126 BMEII0354 Brucella melitensis bv. 1 str. 16M sugar transporter NP_541332.1 367238 D 224914 CDS NP_541333.1 17988700 1198127 368248..369195 1 NC_003318.1 D-galactose 1-dehydrogenase 369195 1198127 BMEII0355 Brucella melitensis bv. 1 str. 16M D-galactose 1-dehydrogenase NP_541333.1 368248 D 224914 CDS NP_541334.2 161511177 1198128 369292..371097 1 NC_003318.1 catalyzes the formation of 3-methyl-2-oxobutanoate from 2,3,-dihydroxy-3-methylbutanoate; dihydroxy-acid dehydratase 371097 1198128 BMEII0356 Brucella melitensis bv. 1 str. 16M dihydroxy-acid dehydratase NP_541334.2 369292 D 224914 CDS NP_541335.1 17988702 1198129 371094..372041 1 NC_003318.1 2-dehydro-3-deoxygalactonokinase 372041 1198129 BMEII0357 Brucella melitensis bv. 1 str. 16M 2-dehydro-3-deoxygalactonokinase NP_541335.1 371094 D 224914 CDS NP_541336.1 17988703 1198130 372038..372670 1 NC_003318.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-galactonate 6-phosphate; functions in galactonate metabolism; 2-dehydro-3-deoxy-6-phosphogalactonate aldolase 372670 1198130 BMEII0358 Brucella melitensis bv. 1 str. 16M 2-dehydro-3-deoxy-6-phosphogalactonate aldolase NP_541336.1 372038 D 224914 CDS NP_541337.1 17988704 1198131 372771..373166 1 NC_003318.1 multiple sugar-binding periplasmic receptor CHVE precursor 373166 1198131 BMEII0359 Brucella melitensis bv. 1 str. 16M multiple sugar-binding periplasmic receptor CHVE precursor NP_541337.1 372771 D 224914 CDS NP_541338.1 17988705 1198132 373223..373879 1 NC_003318.1 multiple sugar-binding periplasmic receptor CHVE precursor 373879 1198132 BMEII0360 Brucella melitensis bv. 1 str. 16M multiple sugar-binding periplasmic receptor CHVE precursor NP_541338.1 373223 D 224914 CDS NP_541339.1 17988706 1198133 374025..375614 1 NC_003318.1 sugar transport ATP-binding protein 375614 1198133 BMEII0361 Brucella melitensis bv. 1 str. 16M sugar transport ATP-binding protein NP_541339.1 374025 D 224914 CDS NP_541340.1 17988707 1198134 375614..376804 1 NC_003318.1 xylose transport system permease XYLH 376804 1198134 BMEII0362 Brucella melitensis bv. 1 str. 16M xylose transport system permease XYLH NP_541340.1 375614 D 224914 CDS NP_541341.1 17988708 1198135 complement(376946..377827) 1 NC_003318.1 catalyzes the transamination of D-amino acids and their alpha-keto acids; D-amino acid aminotransferase 377827 1198135 BMEII0363 Brucella melitensis bv. 1 str. 16M D-amino acid aminotransferase NP_541341.1 376946 R 224914 CDS NP_541342.1 17988709 1198136 complement(377915..378538) 1 NC_003318.1 hypothetical protein 378538 1198136 BMEII0364 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541342.1 377915 R 224914 CDS NP_541343.1 17988710 1198137 complement(378545..380218) 1 NC_003318.1 catalyzes the formation of 4-imidazolone-5-propanoate from urocanate during histidine metabolism; urocanate hydratase 380218 1198137 BMEII0365 Brucella melitensis bv. 1 str. 16M urocanate hydratase NP_541343.1 378545 R 224914 CDS NP_541344.1 17988711 1198138 complement(380229..381173) 1 NC_003318.1 N-formylglutamate deformylase 381173 1198138 BMEII0366 Brucella melitensis bv. 1 str. 16M N-formylglutamate deformylase NP_541344.1 380229 R 224914 CDS NP_541345.1 17988712 1198139 complement(381031..381726) 1 NC_003318.1 histidine ammonia-lyase 381726 1198139 BMEII0367 Brucella melitensis bv. 1 str. 16M histidine ammonia-lyase NP_541345.1 381031 R 224914 CDS NP_541346.1 17988713 1198140 complement(381636..383807) 1 NC_003318.1 catalyzing the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third stepin the histidine degradation pathway; imidazolonepropionase 383807 1198140 BMEII0368 Brucella melitensis bv. 1 str. 16M imidazolonepropionase NP_541346.1 381636 R 224914 CDS NP_541347.1 17988714 1198141 383938..385302 1 NC_003318.1 catalyzes the deimination of N-formimino-L-glutamate to ammonia and N-formyl-L-glutamate; N-formimino-L-glutamate deiminase 385302 1198141 BMEII0369 Brucella melitensis bv. 1 str. 16M N-formimino-L-glutamate deiminase NP_541347.1 383938 D 224914 CDS NP_541348.1 17988715 1198142 385314..386057 1 NC_003318.1 histidine utilization repressor 386057 1198142 BMEII0370 Brucella melitensis bv. 1 str. 16M histidine utilization repressor NP_541348.1 385314 D 224914 CDS NP_541349.1 17988716 1198143 complement(386128..387456) 1 NC_003318.1 catalyzes the formation of pyruvate and beta-alanine from L-alanine and 3-oxopropanoate; beta alanine--pyruvate transaminase 387456 1198143 BMEII0371 Brucella melitensis bv. 1 str. 16M beta alanine--pyruvate transaminase NP_541349.1 386128 R 224914 CDS NP_541350.1 17988717 1198144 387602..388150 1 NC_003318.1 MerR family transcriptional regulator 388150 1198144 BMEII0372 Brucella melitensis bv. 1 str. 16M MerR family transcriptional regulator NP_541350.1 387602 D 224914 CDS NP_541351.1 17988718 1198145 complement(388193..389443) 1 NC_003318.1 catalyzes the oxidative deamination of D-amino acids; D-amino acid dehydrogenase small subunit 389443 1198145 BMEII0373 Brucella melitensis bv. 1 str. 16M D-amino acid dehydrogenase small subunit NP_541351.1 388193 R 224914 CDS NP_541352.1 17988719 1198146 complement(389459..390658) 1 NC_003318.1 alanine racemase 390658 1198146 BMEII0374 Brucella melitensis bv. 1 str. 16M alanine racemase NP_541352.1 389459 R 224914 CDS NP_541353.1 17988720 1198147 390899..391366 1 NC_003318.1 AsnC family transcriptional regulator 391366 1198147 BMEII0375 Brucella melitensis bv. 1 str. 16M AsnC family transcriptional regulator NP_541353.1 390899 D 224914 CDS NP_541354.1 17988721 1198148 complement(391514..392368) 1 NC_003318.1 heat resistant agglutinin 1 precursor 392368 1198148 BMEII0376 Brucella melitensis bv. 1 str. 16M heat resistant agglutinin 1 precursor NP_541354.1 391514 R 224914 CDS NP_541355.1 17988722 1198149 complement(392647..393795) 1 NC_003318.1 L-lactate dehydrogenase (cytochrome) 393795 1198149 BMEII0377 Brucella melitensis bv. 1 str. 16M L-lactate dehydrogenase (cytochrome) NP_541355.1 392647 R 224914 CDS NP_541356.1 17988723 1198150 393949..396309 1 NC_003318.1 formate dehydrogenase alpha chain 396309 1198150 BMEII0378 Brucella melitensis bv. 1 str. 16M formate dehydrogenase alpha chain NP_541356.1 393949 D 224914 CDS NP_541357.1 17988724 1198151 396306..396605 1 NC_003318.1 hypothetical protein 396605 1198151 BMEII0379 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541357.1 396306 D 224914 CDS NP_541358.1 17988725 1198152 396837..398009 1 NC_003318.1 acriflavin resistance protein A 398009 1198152 BMEII0380 Brucella melitensis bv. 1 str. 16M acriflavin resistance protein A NP_541358.1 396837 D 224914 CDS NP_541359.1 17988726 1198153 398018..399112 1 NC_003318.1 acriflavin resistance protein E 399112 1198153 BMEII0381 Brucella melitensis bv. 1 str. 16M acriflavin resistance protein E NP_541359.1 398018 D 224914 CDS NP_541360.1 17988727 1198154 399109..402183 1 NC_003318.1 acriflavin resistance protein D 402183 1198154 BMEII0382 Brucella melitensis bv. 1 str. 16M acriflavin resistance protein D NP_541360.1 399109 D 224914 CDS NP_541361.1 17988728 1198155 402286..403053 1 NC_003318.1 GntR family transcriptional regulator 403053 1198155 BMEII0383 Brucella melitensis bv. 1 str. 16M GntR family transcriptional regulator NP_541361.1 402286 D 224914 CDS NP_541362.1 17988729 1198156 403050..404087 1 NC_003318.1 glucosamine-6-phosphate isomerase 404087 1198156 BMEII0384 Brucella melitensis bv. 1 str. 16M glucosamine-6-phosphate isomerase NP_541362.1 403050 D 224914 CDS NP_541363.1 17988730 1198157 404084..405250 1 NC_003318.1 N-acetylglucosamine-6-phosphate deacetylase 405250 1198157 BMEII0385 Brucella melitensis bv. 1 str. 16M N-acetylglucosamine-6-phosphate deacetylase NP_541363.1 404084 D 224914 CDS NP_541364.1 17988731 1198158 405258..405986 1 NC_003318.1 hypothetical protein 405986 1198158 BMEII0386 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541364.1 405258 D 224914 CDS NP_541365.1 17988732 1198159 406130..407014 1 NC_003318.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; formyltetrahydrofolate deformylase 407014 purU 1198159 purU Brucella melitensis bv. 1 str. 16M formyltetrahydrofolate deformylase NP_541365.1 406130 D 224914 CDS NP_541366.1 17988733 1198160 complement(407238..408770) 1 NC_003318.1 piperideine-6-carboxylate dehydrogenase 408770 1198160 BMEII0388 Brucella melitensis bv. 1 str. 16M piperideine-6-carboxylate dehydrogenase NP_541366.1 407238 R 224914 CDS NP_541367.1 17988734 1198161 complement(408844..409572) 1 NC_003318.1 hypothetical protein 409572 1198161 BMEII0389 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541367.1 408844 R 224914 CDS NP_541368.1 17988735 1198162 409693..410625 1 NC_003318.1 LysR family transcriptional regulator 410625 1198162 BMEII0390 Brucella melitensis bv. 1 str. 16M LysR family transcriptional regulator NP_541368.1 409693 D 224914 CDS NP_541369.1 17988736 1198163 410716..412008 1 NC_003318.1 sarcosine oxidase beta subunit 412008 1198163 BMEII0391 Brucella melitensis bv. 1 str. 16M sarcosine oxidase beta subunit NP_541369.1 410716 D 224914 CDS NP_541370.1 17988737 1198164 complement(412103..414214) 1 NC_003318.1 transcription accessory protein 414214 1198164 BMEII0392 Brucella melitensis bv. 1 str. 16M transcription accessory protein NP_541370.1 412103 R 224914 CDS NP_541371.1 17988738 1198165 414624..414932 1 NC_003318.1 ArsR family transcriptional regulator 414932 1198165 BMEII0393 Brucella melitensis bv. 1 str. 16M ArsR family transcriptional regulator NP_541371.1 414624 D 224914 CDS NP_541372.1 17988739 1198166 414976..416091 1 NC_003318.1 glycerol trinitrate reductase 416091 1198166 BMEII0394 Brucella melitensis bv. 1 str. 16M glycerol trinitrate reductase NP_541372.1 414976 D 224914 CDS NP_541373.1 17988740 1198167 complement(416129..416611) 1 NC_003318.1 AsnC family transcriptional regulator 416611 1198167 BMEII0395 Brucella melitensis bv. 1 str. 16M AsnC family transcriptional regulator NP_541373.1 416129 R 224914 CDS NP_541374.1 17988741 1198168 416622..417617 1 NC_003318.1 arginase 417617 1198168 BMEII0396 Brucella melitensis bv. 1 str. 16M arginase NP_541374.1 416622 D 224914 CDS NP_541375.1 17988742 1198169 417653..418732 1 NC_003318.1 catalyzes the formation of L-proline from L-ornithine; ornithine cyclodeaminase 418732 1198169 BMEII0397 Brucella melitensis bv. 1 str. 16M ornithine cyclodeaminase NP_541375.1 417653 D 224914 CDS NP_541376.1 17988743 1198170 complement(418745..419170) 1 NC_003318.1 SEC-independent protein translocase TATC 419170 1198170 BMEII0398 Brucella melitensis bv. 1 str. 16M SEC-independent protein translocase TATC NP_541376.1 418745 R 224914 CDS NP_541377.1 17988744 1198171 419185..419751 1 NC_003318.1 hypothetical protein 419751 1198171 BMEII0399 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541377.1 419185 D 224914 CDS NP_541378.1 17988745 1198172 420187..420708 1 NC_003318.1 DNA-binding protein 420708 1198172 BMEII0400 Brucella melitensis bv. 1 str. 16M DNA-binding protein NP_541378.1 420187 D 224914 CDS NP_541379.1 17988746 1198173 420941..421930 1 NC_003318.1 thioredoxin 421930 1198173 BMEII0401 Brucella melitensis bv. 1 str. 16M thioredoxin NP_541379.1 420941 D 224914 CDS NP_541380.1 17988747 1198174 422000..422698 1 NC_003318.1 ATP-dependent protease LA 2 422698 1198174 BMEII0402 Brucella melitensis bv. 1 str. 16M ATP-dependent protease LA 2 NP_541380.1 422000 D 224914 CDS NP_541381.1 17988748 1198175 422875..423069 1 NC_003318.1 cytosolic protein 423069 1198175 BMEII0403 Brucella melitensis bv. 1 str. 16M cytosolic protein NP_541381.1 422875 D 224914 CDS NP_541382.1 17988749 1198176 423369..424481 1 NC_003318.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase 424481 1198176 BMEII0404 Brucella melitensis bv. 1 str. 16M 3-isopropylmalate dehydrogenase NP_541382.1 423369 D 224914 CDS NP_541383.1 17988750 1198177 424622..425674 1 NC_003318.1 ADA regulatory protein / O-6-methylguanine-DNA-alkyltransferase 425674 1198177 BMEII0405 Brucella melitensis bv. 1 str. 16M ADA regulatory protein / O-6-methylguanine-DNA-alkyltransferase NP_541383.1 424622 D 224914 CDS NP_541384.1 17988751 1198178 complement(425732..427630) 1 NC_003318.1 proline/betaine transporter 427630 1198178 BMEII0406 Brucella melitensis bv. 1 str. 16M proline/betaine transporter NP_541384.1 425732 R 224914 CDS NP_541385.2 161511176 1198179 428153..429187 1 NC_003318.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 429187 1198179 BMEII0407 Brucella melitensis bv. 1 str. 16M aspartate-semialdehyde dehydrogenase NP_541385.2 428153 D 224914 CDS NP_541386.1 17988753 1198180 complement(429251..429724) 1 NC_003318.1 MarR family transcriptional regulator 429724 1198180 BMEII0408 Brucella melitensis bv. 1 str. 16M MarR family transcriptional regulator NP_541386.1 429251 R 224914 CDS NP_541387.1 17988754 1198181 429885..430334 1 NC_003318.1 osmotically inducible protein C 430334 1198181 BMEII0409 Brucella melitensis bv. 1 str. 16M osmotically inducible protein C NP_541387.1 429885 D 224914 CDS NP_541388.1 17988755 1198182 complement(430385..430807) 1 NC_003318.1 acetylglutamate kinase 430807 1198182 BMEII0410 Brucella melitensis bv. 1 str. 16M acetylglutamate kinase NP_541388.1 430385 R 224914 CDS NP_541389.2 161511175 1198183 complement(430893..431498) 1 NC_003318.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit 431498 leuD 1198183 leuD Brucella melitensis bv. 1 str. 16M isopropylmalate isomerase small subunit NP_541389.2 430893 R 224914 CDS NP_541390.1 17988757 1198184 complement(431563..431769) 1 NC_003318.1 hypothetical protein 431769 1198184 BMEII0412 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541390.1 431563 R 224914 CDS NP_541391.1 17988758 1198185 431908..432798 1 NC_003318.1 citrate lyase beta chain / Citryl-CoA lyase subunit 432798 1198185 BMEII0413 Brucella melitensis bv. 1 str. 16M citrate lyase beta chain / Citryl-CoA lyase subunit NP_541391.1 431908 D 224914 CDS NP_541392.1 17988759 1198186 432816..433022 1 NC_003318.1 hypothetical protein 433022 1198186 BMEII0414 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541392.1 432816 D 224914 CDS NP_541393.1 17988760 1198187 433022..433375 1 NC_003318.1 lactoylglutathione lyase 433375 1198187 BMEII0415 Brucella melitensis bv. 1 str. 16M lactoylglutathione lyase NP_541393.1 433022 D 224914 CDS NP_541394.1 17988761 1198188 complement(433405..435606) 1 NC_003318.1 peptidyl-dipeptidase DCP 435606 1198188 BMEII0416 Brucella melitensis bv. 1 str. 16M peptidyl-dipeptidase DCP NP_541394.1 433405 R 224914 CDS NP_541395.1 17988762 1198189 435579..435782 1 NC_003318.1 hypothetical protein 435782 1198189 BMEII0417 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541395.1 435579 D 224914 CDS NP_541396.1 17988763 1198190 435779..437176 1 NC_003318.1 Mg2+ transporter 437176 1198190 BMEII0418 Brucella melitensis bv. 1 str. 16M Mg2+ transporter NP_541396.1 435779 D 224914 CDS NP_541397.1 17988764 1198191 437419..439245 1 NC_003318.1 GTP-binding protein TypA 439245 1198191 BMEII0419 Brucella melitensis bv. 1 str. 16M GTP-binding protein TypA NP_541397.1 437419 D 224914 CDS NP_541398.1 17988765 1198192 439367..439984 1 NC_003318.1 thymidylate synthase 439984 1198192 BMEII0420 Brucella melitensis bv. 1 str. 16M thymidylate synthase NP_541398.1 439367 D 224914 CDS NP_541399.1 17988766 1198193 440215..440421 1 NC_003318.1 hypothetical protein 440421 1198193 BMEII0421 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541399.1 440215 D 224914 CDS NP_541400.1 17988767 1198194 440418..441440 1 NC_003318.1 catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate; fructose-1,6-bisphosphatase 441440 1198194 BMEII0422 Brucella melitensis bv. 1 str. 16M fructose-1,6-bisphosphatase NP_541400.1 440418 D 224914 CDS NP_541401.1 17988768 1198195 441471..442535 1 NC_003318.1 class II aldolase; catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis; fructose-1,6-bisphosphate aldolase 442535 1198195 BMEII0423 Brucella melitensis bv. 1 str. 16M fructose-1,6-bisphosphate aldolase NP_541401.1 441471 D 224914 CDS NP_541402.1 17988769 1198196 complement(442602..443096) 1 NC_003318.1 catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity; ribose-5-phosphate isomerase B 443096 1198196 BMEII0424 Brucella melitensis bv. 1 str. 16M ribose-5-phosphate isomerase B NP_541402.1 442602 R 224914 CDS NP_541403.1 17988770 1198197 complement(443069..443839) 1 NC_003318.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 443839 tpiA 1198197 tpiA Brucella melitensis bv. 1 str. 16M triosephosphate isomerase NP_541403.1 443069 R 224914 CDS NP_541404.1 17988771 1198198 complement(443852..444616) 1 NC_003318.1 DeoR family transcriptional regulator 444616 1198198 BMEII0426 Brucella melitensis bv. 1 str. 16M DeoR family transcriptional regulator NP_541404.1 443852 R 224914 CDS NP_541405.1 17988772 1198199 complement(444704..445654) 1 NC_003318.1 ERI operon repressor 445654 1198199 BMEII0427 Brucella melitensis bv. 1 str. 16M ERI operon repressor NP_541405.1 444704 R 224914 CDS NP_541406.1 17988773 1198200 complement(445682..446614) 1 NC_003318.1 D-erythrulose 4-phosphate dehydrogenase 446614 1198200 BMEII0428 Brucella melitensis bv. 1 str. 16M D-erythrulose 4-phosphate dehydrogenase NP_541406.1 445682 R 224914 CDS NP_541407.1 17988774 1198201 complement(446622..448130) 1 NC_003318.1 in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane; glycerol-3-phosphate dehydrogenase 448130 1198201 BMEII0429 Brucella melitensis bv. 1 str. 16M glycerol-3-phosphate dehydrogenase NP_541407.1 446622 R 224914 CDS NP_541408.1 17988775 1198202 complement(448143..449705) 1 NC_003318.1 erythritol kinase 449705 1198202 BMEII0430 Brucella melitensis bv. 1 str. 16M erythritol kinase NP_541408.1 448143 R 224914 CDS NP_541409.1 17988776 1198203 450731..451096 1 NC_003318.1 hypothetical protein 451096 1198203 BMEII0431 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541409.1 450731 D 224914 CDS NP_541410.1 17988777 1198204 451093..452637 1 NC_003318.1 ribose ABC transporter ATP-binding protein 452637 1198204 BMEII0432 Brucella melitensis bv. 1 str. 16M ribose ABC transporter ATP-binding protein NP_541410.1 451093 D 224914 CDS NP_541411.1 17988778 1198205 452661..453701 1 NC_003318.1 ribose ABC transporter permease 453701 1198205 BMEII0433 Brucella melitensis bv. 1 str. 16M ribose ABC transporter permease NP_541411.1 452661 D 224914 CDS NP_541412.1 17988779 1198206 453698..453952 1 NC_003318.1 hypothetical protein 453952 1198206 BMEII0434 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541412.1 453698 D 224914 CDS NP_541413.1 17988780 1198207 453936..454814 1 NC_003318.1 D-ribose-binding periplasmic protein precursor 454814 1198207 BMEII0435 Brucella melitensis bv. 1 str. 16M D-ribose-binding periplasmic protein precursor NP_541413.1 453936 D 224914 CDS NP_541414.1 17988781 1198208 454995..455843 1 NC_003318.1 DeoR family transcriptional regulator 455843 1198208 BMEII0436 Brucella melitensis bv. 1 str. 16M DeoR family transcriptional regulator NP_541414.1 454995 D 224914 CDS NP_541415.1 17988782 1198209 456466..457905 1 NC_003318.1 hypothetical protein 457905 1198209 BMEII0437 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541415.1 456466 D 224914 CDS NP_541416.1 17988783 1198210 457905..459239 1 NC_003318.1 L-gulonolactone oxidase 459239 1198210 BMEII0438 Brucella melitensis bv. 1 str. 16M L-gulonolactone oxidase NP_541416.1 457905 D 224914 CDS NP_541417.1 17988784 1198211 459211..459690 1 NC_003318.1 transporter, DME family 459690 1198211 BMEII0439 Brucella melitensis bv. 1 str. 16M transporter, DME family NP_541417.1 459211 D 224914 CDS NP_541418.1 17988785 1198212 459739..460749 1 NC_003318.1 dTDP-glucose 4,6-dehydratase 460749 1198212 BMEII0440 Brucella melitensis bv. 1 str. 16M dTDP-glucose 4,6-dehydratase NP_541418.1 459739 D 224914 CDS NP_541419.1 17988786 1198213 460760..462214 1 NC_003318.1 acetylornithine aminotransferase 462214 1198213 BMEII0441 Brucella melitensis bv. 1 str. 16M acetylornithine aminotransferase NP_541419.1 460760 D 224914 CDS NP_541420.1 17988787 1198214 complement(462378..464006) 1 NC_003318.1 hypothetical protein 464006 1198214 BMEII0442 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541420.1 462378 R 224914 CDS NP_541421.1 17988788 1198215 complement(464174..464557) 1 NC_003318.1 hypothetical protein 464557 1198215 BMEII0443 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541421.1 464174 R 224914 CDS NP_541422.1 17988789 1198216 complement(464789..464998) 1 NC_003318.1 hypothetical protein 464998 1198216 BMEII0444 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541422.1 464789 R 224914 CDS NP_541423.1 17988790 1198217 complement(465524..465790) 1 NC_003318.1 transposase 465790 1198217 BMEII0445 Brucella melitensis bv. 1 str. 16M transposase NP_541423.1 465524 R 224914 CDS NP_541424.1 17988791 1198218 complement(466304..468199) 1 NC_003318.1 hypothetical protein 468199 1198218 BMEII0446 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541424.1 466304 R 224914 CDS NP_541425.1 17988792 1198219 complement(468186..469115) 1 NC_003318.1 transporter 469115 1198219 BMEII0447 Brucella melitensis bv. 1 str. 16M transporter NP_541425.1 468186 R 224914 CDS NP_541426.1 17988793 1198220 complement(469123..469863) 1 NC_003318.1 zinc metallopeptidase 469863 1198220 BMEII0448 Brucella melitensis bv. 1 str. 16M zinc metallopeptidase NP_541426.1 469123 R 224914 CDS NP_541427.1 17988794 1198221 complement(470479..472830) 1 NC_003318.1 type I restriction-modification system restriction subunit 472830 1198221 BMEII0449 Brucella melitensis bv. 1 str. 16M type I restriction-modification system restriction subunit NP_541427.1 470479 R 224914 CDS NP_541428.1 17988795 1198222 complement(472827..474050) 1 NC_003318.1 type I restriction-modification system specificity subunit 474050 1198222 BMEII0450 Brucella melitensis bv. 1 str. 16M type I restriction-modification system specificity subunit NP_541428.1 472827 R 224914 CDS NP_541429.1 17988796 1198223 complement(474040..475596) 1 NC_003318.1 type I restriction-modification system methylation subunit 475596 1198223 BMEII0451 Brucella melitensis bv. 1 str. 16M type I restriction-modification system methylation subunit NP_541429.1 474040 R 224914 CDS NP_541430.1 17988797 1198224 complement(475574..476203) 1 NC_003318.1 type I restriction-modification enzyme, S subunit 476203 1198224 BMEII0452 Brucella melitensis bv. 1 str. 16M type I restriction-modification enzyme, S subunit NP_541430.1 475574 R 224914 CDS NP_541431.1 17988798 1198225 477292..477564 1 NC_003318.1 transposase 477564 1198225 BMEII0453 Brucella melitensis bv. 1 str. 16M transposase NP_541431.1 477292 D 224914 CDS NP_541432.1 17988799 1198226 477525..477722 1 NC_003318.1 hypothetical protein 477722 1198226 BMEII0454 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541432.1 477525 D 224914 CDS NP_541433.1 17988800 1198227 477892..478104 1 NC_003318.1 hypothetical protein 478104 1198227 BMEII0455 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541433.1 477892 D 224914 CDS NP_541434.1 17988801 1198228 478273..478773 1 NC_003318.1 hypothetical protein 478773 1198228 BMEII0456 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541434.1 478273 D 224914 CDS NP_541435.1 17988802 1198229 complement(478780..479502) 1 NC_003318.1 hypothetical protein 479502 1198229 BMEII0457 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541435.1 478780 R 224914 CDS NP_541436.1 17988803 1198230 complement(479480..480031) 1 NC_003318.1 hypothetical protein 480031 1198230 BMEII0458 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541436.1 479480 R 224914 CDS NP_541437.1 17988804 1198231 complement(480228..480479) 1 NC_003318.1 hypothetical protein 480479 1198231 BMEII0459 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541437.1 480228 R 224914 CDS NP_541438.1 17988805 1198232 complement(480557..481576) 1 NC_003318.1 2-nitropropane dioxygenase 481576 1198232 BMEII0460 Brucella melitensis bv. 1 str. 16M 2-nitropropane dioxygenase NP_541438.1 480557 R 224914 CDS NP_541439.1 17988806 1198233 482032..483054 1 NC_003318.1 hypothetical protein 483054 1198233 BMEII0461 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541439.1 482032 D 224914 CDS NP_541440.1 17988807 1198234 483306..485861 1 NC_003318.1 ATP-dependent helicase 485861 1198234 BMEII0462 Brucella melitensis bv. 1 str. 16M ATP-dependent helicase NP_541440.1 483306 D 224914 CDS NP_541441.1 17988808 1198235 485858..486574 1 NC_003318.1 ICC-like phosphoesterase 486574 1198235 BMEII0463 Brucella melitensis bv. 1 str. 16M ICC-like phosphoesterase NP_541441.1 485858 D 224914 CDS NP_541442.1 17988809 1198236 complement(486672..487394) 1 NC_003318.1 hypothetical protein 487394 1198236 BMEII0464 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541442.1 486672 R 224914 CDS NP_541443.1 17988810 1198237 complement(487498..488445) 1 NC_003318.1 permease 488445 1198237 BMEII0465 Brucella melitensis bv. 1 str. 16M permease NP_541443.1 487498 R 224914 CDS NP_541444.1 17988811 1198238 complement(488685..489638) 1 NC_003318.1 TPR repeat-containing protein 489638 1198238 BMEII0466 Brucella melitensis bv. 1 str. 16M TPR repeat-containing protein NP_541444.1 488685 R 224914 CDS NP_541445.1 17988812 1198239 491964..492359 1 NC_003318.1 MerR family transcriptional regulator 492359 1198239 BMEII0467 Brucella melitensis bv. 1 str. 16M MerR family transcriptional regulator NP_541445.1 491964 D 224914 CDS NP_541446.1 17988813 1198240 complement(492414..492773) 1 NC_003318.1 hypothetical protein 492773 1198240 BMEII0468 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541446.1 492414 R 224914 CDS NP_541447.1 17988814 1198241 complement(492789..493202) 1 NC_003318.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 493202 1198241 BMEII0469 Brucella melitensis bv. 1 str. 16M camphor resistance protein CrcB NP_541447.1 492789 R 224914 CDS NP_541448.2 161511174 1198242 complement(493199..493600) 1 NC_003318.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 493600 1198242 BMEII0470 Brucella melitensis bv. 1 str. 16M camphor resistance protein CrcB NP_541448.2 493199 R 224914 CDS NP_541449.1 17988816 1198243 493898..494092 1 NC_003318.1 hypothetical protein 494092 1198243 BMEII0471 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541449.1 493898 D 224914 CDS NP_541450.1 17988817 1198244 494056..495042 1 NC_003318.1 membrane fusion protein MTRC 495042 1198244 BMEII0472 Brucella melitensis bv. 1 str. 16M membrane fusion protein MTRC NP_541450.1 494056 D 224914 CDS NP_541451.1 17988818 1198245 495065..498142 1 NC_003318.1 acriflavin resistance protein F 498142 1198245 BMEII0473 Brucella melitensis bv. 1 str. 16M acriflavin resistance protein F NP_541451.1 495065 D 224914 CDS NP_541452.1 17988819 1198246 complement(498326..499531) 1 NC_003318.1 catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate; mannonate dehydratase 499531 1198246 BMEII0474 Brucella melitensis bv. 1 str. 16M mannonate dehydratase NP_541452.1 498326 R 224914 CDS NP_541453.1 17988820 1198247 complement(499592..500377) 1 NC_003318.1 GntR family transcriptional regulator 500377 1198247 BMEII0475 Brucella melitensis bv. 1 str. 16M GntR family transcriptional regulator NP_541453.1 499592 R 224914 CDS NP_541454.1 17988821 1198248 500694..501818 1 NC_003318.1 catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; uronate isomerase 501818 1198248 BMEII0476 Brucella melitensis bv. 1 str. 16M uronate isomerase NP_541454.1 500694 D 224914 CDS NP_541455.1 17988822 1198249 501785..502093 1 NC_003318.1 uronate isomerase 502093 1198249 BMEII0477 Brucella melitensis bv. 1 str. 16M uronate isomerase NP_541455.1 501785 D 224914 CDS NP_541456.1 17988823 1198250 502090..503598 1 NC_003318.1 D-mannonate oxidoreductase 503598 1198250 BMEII0478 Brucella melitensis bv. 1 str. 16M D-mannonate oxidoreductase NP_541456.1 502090 D 224914 CDS NP_541457.1 17988824 1198251 503848..504939 1 NC_003318.1 ABC transporter substrate-binding protein 504939 1198251 BMEII0479 Brucella melitensis bv. 1 str. 16M ABC transporter substrate-binding protein NP_541457.1 503848 D 224914 CDS NP_541458.1 17988825 1198252 complement(504947..505087) 1 NC_003318.1 hypothetical protein 505087 1198252 BMEII0480 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541458.1 504947 R 224914 CDS NP_541459.1 17988826 1198253 505060..506070 1 NC_003318.1 ABC transporter ATP-binding protein 506070 1198253 BMEII0481 Brucella melitensis bv. 1 str. 16M ABC transporter ATP-binding protein NP_541459.1 505060 D 224914 CDS NP_541460.1 17988827 1198254 506079..506351 1 NC_003318.1 hypothetical protein 506351 1198254 BMEII0482 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541460.1 506079 D 224914 CDS NP_541461.1 17988828 1198255 506360..506977 1 NC_003318.1 ABC transporter membrane protein 506977 1198255 BMEII0483 Brucella melitensis bv. 1 str. 16M ABC transporter membrane protein NP_541461.1 506360 D 224914 CDS NP_541462.1 17988829 1198256 507065..507820 1 NC_003318.1 ABC transporter membrane protein 507820 1198256 BMEII0484 Brucella melitensis bv. 1 str. 16M ABC transporter membrane protein NP_541462.1 507065 D 224914 CDS NP_541463.1 17988830 1198257 508140..509441 1 NC_003318.1 D-galactarate dehydratase 509441 1198257 BMEII0485 Brucella melitensis bv. 1 str. 16M D-galactarate dehydratase NP_541463.1 508140 D 224914 CDS NP_541464.1 17988831 1198258 complement(509452..509907) 1 NC_003318.1 Inhibits transcription at high concentrations of nickel; nickel responsive regulator 509907 1198258 BMEII0486 Brucella melitensis bv. 1 str. 16M nickel responsive regulator NP_541464.1 509452 R 224914 CDS NP_541465.1 17988832 1198259 510117..511697 1 NC_003318.1 nickel-binding periplasmic protein precursor 511697 1198259 BMEII0487 Brucella melitensis bv. 1 str. 16M nickel-binding periplasmic protein precursor NP_541465.1 510117 D 224914 CDS NP_541466.1 17988833 1198260 511976..512641 1 NC_003318.1 nickel transport system permease NIKB 512641 1198260 BMEII0488 Brucella melitensis bv. 1 str. 16M nickel transport system permease NIKB NP_541466.1 511976 D 224914 CDS NP_541467.1 17988834 1198261 512656..513510 1 NC_003318.1 with NikABDE is involved in nickel transport into the cell; nickel transporter permease NikC 513510 nikC 1198261 nikC Brucella melitensis bv. 1 str. 16M nickel transporter permease NikC NP_541467.1 512656 D 224914 CDS NP_541468.1 17988835 1198262 513507..514295 1 NC_003318.1 with NikABCE is involved in nickel transport into the cell; nickel transporter ATP-binding protein NikD 514295 nikD 1198262 nikD Brucella melitensis bv. 1 str. 16M nickel transporter ATP-binding protein NikD NP_541468.1 513507 D 224914 CDS NP_541469.1 17988836 1198263 514292..515092 1 NC_003318.1 with NikABCD is involved with nickel transport into the cell; nickel transporter ATP-binding protein NikE 515092 nikE 1198263 nikE Brucella melitensis bv. 1 str. 16M nickel transporter ATP-binding protein NikE NP_541469.1 514292 D 224914 CDS NP_541470.1 17988837 1198264 complement(515225..516412) 1 NC_003318.1 acyl-CoA dehydrogenase 516412 1198264 BMEII0492 Brucella melitensis bv. 1 str. 16M acyl-CoA dehydrogenase NP_541470.1 515225 R 224914 CDS NP_541471.1 17988838 1198265 complement(516708..517427) 1 NC_003318.1 LysR family transcriptional regulator 517427 1198265 BMEII0493 Brucella melitensis bv. 1 str. 16M LysR family transcriptional regulator NP_541471.1 516708 R 224914 CDS NP_541472.1 17988839 1198266 complement(517731..518018) 1 NC_003318.1 hypothetical protein 518018 1198266 BMEII0494 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541472.1 517731 R 224914 CDS NP_541473.1 17988840 1198267 518268..520121 1 NC_003318.1 acyl-CoA dehydrogenase 520121 1198267 BMEII0495 Brucella melitensis bv. 1 str. 16M acyl-CoA dehydrogenase NP_541473.1 518268 D 224914 CDS NP_541474.1 17988841 1198268 520141..521394 1 NC_003318.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 521394 1198268 BMEII0496 Brucella melitensis bv. 1 str. 16M acetyl-CoA acetyltransferase NP_541474.1 520141 D 224914 CDS NP_541475.1 17988842 1198269 521410..523626 1 NC_003318.1 enoyl-CoA hydratase 523626 1198269 BMEII0497 Brucella melitensis bv. 1 str. 16M enoyl-CoA hydratase NP_541475.1 521410 D 224914 CDS NP_541476.1 17988843 1198270 523864..524520 1 NC_003318.1 DNA-binding protein RDGA 524520 1198270 BMEII0498 Brucella melitensis bv. 1 str. 16M DNA-binding protein RDGA NP_541476.1 523864 D 224914 CDS NP_541477.1 17988844 1198271 524701..525480 1 NC_003318.1 succinoglycan biosynthesis protein EXOI 525480 1198271 BMEII0499 Brucella melitensis bv. 1 str. 16M succinoglycan biosynthesis protein EXOI NP_541477.1 524701 D 224914 CDS NP_541478.1 17988845 1198272 complement(525568..527223) 1 NC_003318.1 class I; LysRS1; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri this enzyme charges both tRNA molecules for lysine that exist in this organism (but the tRNALysUUU very poorly) and in the presence of LysRS2 can charge tRNAPyl with lysine; lysyl-tRNA synthetase 527223 lysK 1198272 lysK Brucella melitensis bv. 1 str. 16M lysyl-tRNA synthetase NP_541478.1 525568 R 224914 CDS NP_541479.1 17988846 1198273 527403..527828 1 NC_003318.1 cytoplasmic protein 527828 1198273 BMEII0501 Brucella melitensis bv. 1 str. 16M cytoplasmic protein NP_541479.1 527403 D 224914 CDS NP_541480.1 17988847 1198274 complement(527890..528525) 1 NC_003318.1 carbonic anhydrase 528525 1198274 BMEII0502 Brucella melitensis bv. 1 str. 16M carbonic anhydrase NP_541480.1 527890 R 224914 CDS NP_541481.1 17988848 1198275 complement(528674..529090) 1 NC_003318.1 hypothetical protein 529090 1198275 BMEII0503 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541481.1 528674 R 224914 CDS NP_541482.1 17988849 1198276 529373..530986 1 NC_003318.1 oligopeptide-binding protein appa precursor 530986 1198276 BMEII0504 Brucella melitensis bv. 1 str. 16M oligopeptide-binding protein appa precursor NP_541482.1 529373 D 224914 CDS NP_541483.1 17988850 1198277 531004..532002 1 NC_003318.1 oligopeptide transport system permease APPB 532002 1198277 BMEII0505 Brucella melitensis bv. 1 str. 16M oligopeptide transport system permease APPB NP_541483.1 531004 D 224914 CDS NP_541484.1 17988851 1198278 531999..532829 1 NC_003318.1 oligopeptide transport system permease OPPC 532829 1198278 BMEII0506 Brucella melitensis bv. 1 str. 16M oligopeptide transport system permease OPPC NP_541484.1 531999 D 224914 CDS NP_541485.1 17988852 1198279 532673..533581 1 NC_003318.1 oligopeptide transport ATP-binding protein OPPD 533581 1198279 BMEII0507 Brucella melitensis bv. 1 str. 16M oligopeptide transport ATP-binding protein OPPD NP_541485.1 532673 D 224914 CDS NP_541486.1 17988853 1198280 533505..534326 1 NC_003318.1 oligopeptide transport ATP-binding protein OPPF 534326 1198280 BMEII0508 Brucella melitensis bv. 1 str. 16M oligopeptide transport ATP-binding protein OPPF NP_541486.1 533505 D 224914 CDS NP_541487.1 17988854 1198281 complement(534417..535319) 1 NC_003318.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase 535319 1198281 BMEII0509 Brucella melitensis bv. 1 str. 16M pyrroline-5-carboxylate reductase NP_541487.1 534417 R 224914 CDS NP_541488.1 17988855 1198282 535493..536452 1 NC_003318.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 536452 1198282 BMEII0510 Brucella melitensis bv. 1 str. 16M bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase NP_541488.1 535493 D 224914 CDS NP_541489.1 17988856 1198283 complement(536544..538367) 1 NC_003318.1 catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate; phosphogluconate dehydratase 538367 1198283 BMEII0511 Brucella melitensis bv. 1 str. 16M phosphogluconate dehydratase NP_541489.1 536544 R 224914 CDS NP_541490.1 17988857 1198284 complement(538403..539116) 1 NC_003318.1 catalyzes the formation of 6-phospho-D-gluconate from 6-phospho-D-glucono-1,5-lactone; 6-phosphogluconolactonase 539116 1198284 BMEII0512 Brucella melitensis bv. 1 str. 16M 6-phosphogluconolactonase NP_541490.1 538403 R 224914 CDS NP_541491.1 17988858 1198285 complement(539230..540705) 1 NC_003318.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 540705 1198285 BMEII0513 Brucella melitensis bv. 1 str. 16M glucose-6-phosphate 1-dehydrogenase NP_541491.1 539230 R 224914 CDS NP_541492.1 17988859 1198286 540976..541725 1 NC_003318.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 541725 fabG 1198286 fabG Brucella melitensis bv. 1 str. 16M 3-ketoacyl-ACP reductase NP_541492.1 540976 D 224914 CDS NP_541493.1 17988860 1198287 complement(541814..543103) 1 NC_003318.1 multidrug resistance protein 1 543103 1198287 BMEII0515 Brucella melitensis bv. 1 str. 16M multidrug resistance protein 1 NP_541493.1 541814 R 224914 CDS NP_541494.1 17988861 1198288 complement(543285..543584) 1 NC_003318.1 hypothetical protein 543584 1198288 BMEII0516 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541494.1 543285 R 224914 CDS NP_541495.1 17988862 1198289 complement(543581..544321) 1 NC_003318.1 branched chain amino acid ABC transporter 544321 1198289 BMEII0517 Brucella melitensis bv. 1 str. 16M branched chain amino acid ABC transporter NP_541495.1 543581 R 224914 CDS NP_541496.1 17988863 1198290 544697..545161 1 NC_003318.1 transcriptional regulator AZLB 545161 1198290 BMEII0518 Brucella melitensis bv. 1 str. 16M transcriptional regulator AZLB NP_541496.1 544697 D 224914 CDS NP_541497.1 17988864 1198291 545552..546220 1 NC_003318.1 iron-regulated protein FrpC 546220 1198291 BMEII0519 Brucella melitensis bv. 1 str. 16M iron-regulated protein FrpC NP_541497.1 545552 D 224914 CDS NP_541498.1 17988865 1198292 546509..546946 1 NC_003318.1 MarR family transcriptional regulator 546946 1198292 BMEII0520 Brucella melitensis bv. 1 str. 16M MarR family transcriptional regulator NP_541498.1 546509 D 224914 CDS NP_541499.1 17988866 1198293 complement(546957..548576) 1 NC_003318.1 oxidoreductase 548576 1198293 BMEII0521 Brucella melitensis bv. 1 str. 16M oxidoreductase NP_541499.1 546957 R 224914 CDS NP_541500.1 17988867 1198294 complement(548297..548662) 1 NC_003318.1 crystal structure of protein from Xanthomonas shows pentameric toroidal structure; physiological function is unknown; hypothetical protein 548662 1198294 BMEII0522 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541500.1 548297 R 224914 CDS NP_541501.1 17988868 1198295 complement(548695..550125) 1 NC_003318.1 glutamine synthetase 550125 1198295 BMEII0523 Brucella melitensis bv. 1 str. 16M glutamine synthetase NP_541501.1 548695 R 224914 CDS NP_541502.1 17988869 1198296 complement(550377..550604) 1 NC_003318.1 hypothetical protein 550604 1198296 BMEII0524 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541502.1 550377 R 224914 CDS NP_541503.1 17988870 1198297 550612..550764 1 NC_003318.1 hypothetical protein 550764 1198297 BMEII0525 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541503.1 550612 D 224914 CDS NP_541504.1 17988871 1198298 550837..551814 1 NC_003318.1 LysR family transcriptional regulator 551814 1198298 BMEII0526 Brucella melitensis bv. 1 str. 16M LysR family transcriptional regulator NP_541504.1 550837 D 224914 CDS NP_541505.1 17988872 1198299 551877..553418 1 NC_003318.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 553418 xseA 1198299 xseA Brucella melitensis bv. 1 str. 16M exodeoxyribonuclease VII large subunit NP_541505.1 551877 D 224914 CDS NP_541506.1 17988873 1198300 complement(553484..554857) 1 NC_003318.1 glutamate-cysteine ligase 554857 1198300 BMEII0528 Brucella melitensis bv. 1 str. 16M glutamate-cysteine ligase NP_541506.1 553484 R 224914 CDS NP_541507.1 17988874 1198301 complement(554957..555703) 1 NC_003318.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 555703 1198301 BMEII0529 Brucella melitensis bv. 1 str. 16M 16S ribosomal RNA methyltransferase RsmE NP_541507.1 554957 R 224914 CDS NP_541508.1 17988875 1198302 555953..556390 1 NC_003318.1 MarR family transcriptional regulator 556390 1198302 BMEII0530 Brucella melitensis bv. 1 str. 16M MarR family transcriptional regulator NP_541508.1 555953 D 224914 CDS NP_541509.1 17988876 1198303 556433..558529 1 NC_003318.1 fusaric acid resistance protein FusB / fusaric acid resistance protein FusC 558529 1198303 BMEII0531 Brucella melitensis bv. 1 str. 16M fusaric acid resistance protein FusB / fusaric acid resistance protein FusC NP_541509.1 556433 D 224914 CDS NP_541510.1 17988877 1198304 558556..558765 1 NC_003318.1 hypothetical protein 558765 1198304 BMEII0532 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541510.1 558556 D 224914 CDS NP_541511.1 17988878 1198305 558762..559619 1 NC_003318.1 fusaric acid resistance protein fusE 559619 1198305 BMEII0533 Brucella melitensis bv. 1 str. 16M fusaric acid resistance protein fusE NP_541511.1 558762 D 224914 CDS NP_541512.1 17988879 1198306 559797..560213 1 NC_003318.1 hypothetical protein 560213 1198306 BMEII0534 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541512.1 559797 D 224914 CDS NP_541513.1 17988880 1198307 560170..561204 1 NC_003318.1 iron(III) dicitrate-binding periplasmic protein 561204 1198307 BMEII0535 Brucella melitensis bv. 1 str. 16M iron(III) dicitrate-binding periplasmic protein NP_541513.1 560170 D 224914 CDS NP_541514.1 17988881 1198308 561288..562244 1 NC_003318.1 iron ABC transporter permease 562244 1198308 BMEII0536 Brucella melitensis bv. 1 str. 16M iron ABC transporter permease NP_541514.1 561288 D 224914 CDS NP_541515.1 17988882 1198309 562241..563035 1 NC_003318.1 IRON(III) dicitrate transport ATP-binding protein FECE 563035 1198309 BMEII0537 Brucella melitensis bv. 1 str. 16M IRON(III) dicitrate transport ATP-binding protein FECE NP_541515.1 562241 D 224914 CDS NP_541516.1 17988883 1198310 563092..563334 1 NC_003318.1 hypothetical protein 563334 1198310 BMEII0538 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541516.1 563092 D 224914 CDS NP_541517.1 17988884 1198311 complement(563493..564962) 1 NC_003318.1 cytoplasmic protein 564962 1198311 BMEII0539 Brucella melitensis bv. 1 str. 16M cytoplasmic protein NP_541517.1 563493 R 224914 CDS NP_541518.1 17988885 1198312 complement(564989..565360) 1 NC_003318.1 regulator of purine biosynthesis 565360 1198312 BMEII0540 Brucella melitensis bv. 1 str. 16M regulator of purine biosynthesis NP_541518.1 564989 R 224914 CDS NP_541519.1 17988886 1198313 complement(565373..566260) 1 NC_003318.1 sugar transport system permease 566260 1198313 BMEII0541 Brucella melitensis bv. 1 str. 16M sugar transport system permease NP_541519.1 565373 R 224914 CDS NP_541520.1 17988887 1198314 complement(566558..567754) 1 NC_003318.1 sugar-binding protein 567754 1198314 BMEII0542 Brucella melitensis bv. 1 str. 16M sugar-binding protein NP_541520.1 566558 R 224914 CDS NP_541521.1 17988888 1198315 567973..568746 1 NC_003318.1 short-chain dehydrogenase 568746 1198315 BMEII0543 Brucella melitensis bv. 1 str. 16M short-chain dehydrogenase NP_541521.1 567973 D 224914 CDS NP_541522.1 17988889 1198316 568751..569803 1 NC_003318.1 SN-glycerol-3-phosphate transport ATP-binding protein ugpC 569803 1198316 BMEII0544 Brucella melitensis bv. 1 str. 16M SN-glycerol-3-phosphate transport ATP-binding protein ugpC NP_541522.1 568751 D 224914 CDS NP_541523.1 17988890 1198317 569775..570692 1 NC_003318.1 RPIR family transcriptional regulator 570692 1198317 BMEII0545 Brucella melitensis bv. 1 str. 16M RPIR family transcriptional regulator NP_541523.1 569775 D 224914 CDS NP_541524.1 17988891 1198318 570682..571764 1 NC_003318.1 metal-activated pyridoxal protein 571764 1198318 BMEII0546 Brucella melitensis bv. 1 str. 16M metal-activated pyridoxal protein NP_541524.1 570682 D 224914 CDS NP_541525.1 17988892 1198319 571778..572251 1 NC_003318.1 cytoplasmic protein 572251 1198319 BMEII0547 Brucella melitensis bv. 1 str. 16M cytoplasmic protein NP_541525.1 571778 D 224914 CDS NP_541526.1 17988893 1198320 572782..573978 1 NC_003318.1 glycine betaine/L-proline transport ATP-binding protein proV 573978 1198320 BMEII0548 Brucella melitensis bv. 1 str. 16M glycine betaine/L-proline transport ATP-binding protein proV NP_541526.1 572782 D 224914 CDS NP_541527.1 17988894 1198321 574041..574946 1 NC_003318.1 glycine betaine/L-proline transport system permease proW 574946 1198321 BMEII0549 Brucella melitensis bv. 1 str. 16M glycine betaine/L-proline transport system permease proW NP_541527.1 574041 D 224914 CDS NP_541528.1 17988895 1198322 575003..575866 1 NC_003318.1 glycine betaine/L-proline-binding protein PROX 575866 1198322 BMEII0550 Brucella melitensis bv. 1 str. 16M glycine betaine/L-proline-binding protein PROX NP_541528.1 575003 D 224914 CDS NP_541529.1 17988896 1198323 complement(575912..576811) 1 NC_003318.1 transporter, DME family 576811 1198323 BMEII0551 Brucella melitensis bv. 1 str. 16M transporter, DME family NP_541529.1 575912 R 224914 CDS NP_541530.1 17988897 1198324 complement(577220..577663) 1 NC_003318.1 hypothetical protein 577663 1198324 BMEII0552 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541530.1 577220 R 224914 CDS NP_541531.1 17988898 1198325 complement(577845..579014) 1 NC_003318.1 alcohol dehydrogenase 579014 1198325 BMEII0553 Brucella melitensis bv. 1 str. 16M alcohol dehydrogenase NP_541531.1 577845 R 224914 CDS NP_541532.1 17988899 1198326 complement(579115..580419) 1 NC_003318.1 glutamine synthetase 580419 1198326 BMEII0554 Brucella melitensis bv. 1 str. 16M glutamine synthetase NP_541532.1 579115 R 224914 CDS NP_541533.1 17988900 1198327 complement(580533..581300) 1 NC_003318.1 cytoplasmic protein 581300 1198327 BMEII0555 Brucella melitensis bv. 1 str. 16M cytoplasmic protein NP_541533.1 580533 R 224914 CDS NP_541534.1 17988901 1198328 581461..582303 1 NC_003318.1 RPIR family transcriptional regulator 582303 1198328 BMEII0556 Brucella melitensis bv. 1 str. 16M RPIR family transcriptional regulator NP_541534.1 581461 D 224914 CDS NP_541535.1 17988902 1198329 582391..583788 1 NC_003318.1 rhodocoxin reductase 583788 1198329 BMEII0557 Brucella melitensis bv. 1 str. 16M rhodocoxin reductase NP_541535.1 582391 D 224914 CDS NP_541536.1 17988903 1198330 583439..583645 1 NC_003318.1 rhodocoxin reductase 583645 1198330 BMEII0558 Brucella melitensis bv. 1 str. 16M rhodocoxin reductase NP_541536.1 583439 D 224914 CDS NP_541537.1 17988904 1198331 584622..585725 1 NC_003318.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T 585725 gcvT 1198331 gcvT Brucella melitensis bv. 1 str. 16M glycine cleavage system aminomethyltransferase T NP_541537.1 584622 D 224914 CDS NP_541538.1 17988905 1198332 585722..586099 1 NC_003318.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor; glycine cleavage system protein H 586099 1198332 BMEII0560 Brucella melitensis bv. 1 str. 16M glycine cleavage system protein H NP_541538.1 585722 D 224914 CDS NP_541539.1 17988906 1198333 586104..588902 1 NC_003318.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; glycine dehydrogenase 588902 1198333 BMEII0561 Brucella melitensis bv. 1 str. 16M glycine dehydrogenase NP_541539.1 586104 D 224914 CDS NP_541540.1 17988907 1198334 589690..589950 1 NC_003318.1 hypothetical protein 589950 1198334 BMEII0562 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541540.1 589690 D 224914 CDS NP_541541.1 17988908 1198335 complement(589932..590441) 1 NC_003318.1 proline dehydrogenase 590441 1198335 BMEII0563 Brucella melitensis bv. 1 str. 16M proline dehydrogenase NP_541541.1 589932 R 224914 CDS NP_541542.2 161511173 1198336 590589..594272 1 NC_003318.1 proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichia coli this protein self regulates transcription via a DNA-binding domain at the N-terminus but the protein from Pseudomonas does not have this domain; bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 594272 1198336 BMEII0564 Brucella melitensis bv. 1 str. 16M bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase NP_541542.2 590589 D 224914 CDS NP_541543.1 17988910 1198337 594451..595527 1 NC_003318.1 iron(III)-binding periplasmic protein precursor 595527 1198337 BMEII0565 Brucella melitensis bv. 1 str. 16M iron(III)-binding periplasmic protein precursor NP_541543.1 594451 D 224914 CDS NP_541544.1 17988911 1198338 596211..597887 1 NC_003318.1 iron ABC transporter permease 597887 1198338 BMEII0566 Brucella melitensis bv. 1 str. 16M iron ABC transporter permease NP_541544.1 596211 D 224914 CDS NP_541545.1 17988912 1198339 597884..598945 1 NC_003318.1 iron(III)-transport ATP-binding protein sfuC 598945 1198339 BMEII0567 Brucella melitensis bv. 1 str. 16M iron(III)-transport ATP-binding protein sfuC NP_541545.1 597884 D 224914 CDS NP_541546.1 17988913 1198340 598966..599766 1 NC_003318.1 myo-inositol-1(or 4)-monophosphatase 599766 1198340 BMEII0568 Brucella melitensis bv. 1 str. 16M myo-inositol-1(or 4)-monophosphatase NP_541546.1 598966 D 224914 CDS NP_541547.1 17988914 1198341 complement(599798..600607) 1 NC_003318.1 myo-inositol catabolism protein IolB 600607 1198341 BMEII0569 Brucella melitensis bv. 1 str. 16M myo-inositol catabolism protein IolB NP_541547.1 599798 R 224914 CDS NP_541548.1 17988915 1198342 complement(600611..601513) 1 NC_003318.1 sugar phosphate isomerase/epimerase IolE 601513 1198342 BMEII0570 Brucella melitensis bv. 1 str. 16M sugar phosphate isomerase/epimerase IolE NP_541548.1 600611 R 224914 CDS NP_541549.1 17988916 1198343 complement(601517..603406) 1 NC_003318.1 acetolactate synthase IolD 603406 1198343 BMEII0571 Brucella melitensis bv. 1 str. 16M acetolactate synthase IolD NP_541549.1 601517 R 224914 CDS NP_541550.1 17988917 1198344 complement(603373..605277) 1 NC_003318.1 5-dehydro-2-deoxygluconokinase 605277 1198344 BMEII0572 Brucella melitensis bv. 1 str. 16M 5-dehydro-2-deoxygluconokinase NP_541550.1 603373 R 224914 CDS NP_541551.1 17988918 1198345 complement(605369..606199) 1 NC_003318.1 RPIR family transcriptional regulator 606199 1198345 BMEII0573 Brucella melitensis bv. 1 str. 16M RPIR family transcriptional regulator NP_541551.1 605369 R 224914 CDS NP_541552.1 17988919 1198346 606373..607377 1 NC_003318.1 myo-inositol 2-dehydrogenase 607377 1198346 BMEII0574 Brucella melitensis bv. 1 str. 16M myo-inositol 2-dehydrogenase NP_541552.1 606373 D 224914 CDS NP_541553.1 17988920 1198347 607475..608542 1 NC_003318.1 hypothetical protein 608542 1198347 BMEII0575 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541553.1 607475 D 224914 CDS NP_541554.1 17988921 1198348 complement(608572..609477) 1 NC_003318.1 hydrogen peroxide-inducible genes activator 609477 1198348 BMEII0576 Brucella melitensis bv. 1 str. 16M hydrogen peroxide-inducible genes activator NP_541554.1 608572 R 224914 CDS NP_541555.1 17988922 1198349 609634..610188 1 NC_003318.1 alkyl hydroperoxide reductase 610188 1198349 BMEII0577 Brucella melitensis bv. 1 str. 16M alkyl hydroperoxide reductase NP_541555.1 609634 D 224914 CDS NP_541556.1 17988923 1198350 610268..610795 1 NC_003318.1 AHPD 610795 1198350 BMEII0578 Brucella melitensis bv. 1 str. 16M AHPD NP_541556.1 610268 D 224914 CDS NP_541557.1 17988924 1198351 complement(610873..612153) 1 NC_003318.1 major facilitator transporter 612153 1198351 BMEII0579 Brucella melitensis bv. 1 str. 16M major facilitator transporter NP_541557.1 610873 R 224914 CDS NP_541558.2 161511172 1198352 612862..614466 1 NC_003318.1 laccase; copper-stimulated phenoloxidase and ferroxidase which may be involved in copper detoxification; multicopper oxidase 614466 1198352 BMEII0580 Brucella melitensis bv. 1 str. 16M multicopper oxidase NP_541558.2 612862 D 224914 CDS NP_541559.1 17988926 1198353 614736..615260 1 NC_003318.1 superoxide dismutase (Cu-Zn) 615260 1198353 BMEII0581 Brucella melitensis bv. 1 str. 16M superoxide dismutase (Cu-Zn) NP_541559.1 614736 D 224914 CDS NP_541560.1 17988927 1198354 complement(615742..616845) 1 NC_003318.1 sarcosine oxidase beta subunit 616845 1198354 BMEII0582 Brucella melitensis bv. 1 str. 16M sarcosine oxidase beta subunit NP_541560.1 615742 R 224914 CDS NP_541561.1 17988928 1198355 617082..618185 1 NC_003318.1 iron(III)-transport ATP-binding protein sfuC 618185 1198355 BMEII0583 Brucella melitensis bv. 1 str. 16M iron(III)-transport ATP-binding protein sfuC NP_541561.1 617082 D 224914 CDS NP_541562.1 17988929 1198356 618311..619327 1 NC_003318.1 iron(III)-binding periplasmic protein precursor 619327 1198356 BMEII0584 Brucella melitensis bv. 1 str. 16M iron(III)-binding periplasmic protein precursor NP_541562.1 618311 D 224914 CDS NP_541563.1 17988930 1198357 619399..620745 1 NC_003318.1 iron ABC transporter permease 620745 1198357 BMEII0585 Brucella melitensis bv. 1 str. 16M iron ABC transporter permease NP_541563.1 619399 D 224914 CDS NP_541564.1 17988931 1198358 621296..621697 1 NC_003318.1 hypothetical protein 621697 1198358 BMEII0586 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541564.1 621296 D 224914 CDS NP_541565.1 17988932 1198359 complement(621767..622111) 1 NC_003318.1 sulfide dehydrogenase (flavocytochrome C) 622111 1198359 BMEII0587 Brucella melitensis bv. 1 str. 16M sulfide dehydrogenase (flavocytochrome C) NP_541565.1 621767 R 224914 CDS NP_541566.1 17988933 1198360 622221..623030 1 NC_003318.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth; formate dehydrogenase accessory protein 623030 1198360 BMEII0588 Brucella melitensis bv. 1 str. 16M formate dehydrogenase accessory protein NP_541566.1 622221 D 224914 CDS NP_541567.1 17988934 1198361 complement(623031..623507) 1 NC_003318.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; riboflavin synthase subunit beta 623507 ribH 1198361 ribH Brucella melitensis bv. 1 str. 16M riboflavin synthase subunit beta NP_541567.1 623031 R 224914 CDS NP_541568.1 17988935 1198362 624454..625659 1 NC_003318.1 sugar-binding protein 625659 1198362 BMEII0590 Brucella melitensis bv. 1 str. 16M sugar-binding protein NP_541568.1 624454 D 224914 CDS NP_541569.1 17988936 1198363 625860..626816 1 NC_003318.1 sugar transport system permease 626816 1198363 BMEII0591 Brucella melitensis bv. 1 str. 16M sugar transport system permease NP_541569.1 625860 D 224914 CDS NP_541570.1 17988937 1198364 626813..627694 1 NC_003318.1 sugar transport system permease 627694 1198364 BMEII0592 Brucella melitensis bv. 1 str. 16M sugar transport system permease NP_541570.1 626813 D 224914 CDS NP_541571.1 17988938 1198365 627707..628828 1 NC_003318.1 glucose ABC transporter ATPase 628828 1198365 BMEII0593 Brucella melitensis bv. 1 str. 16M glucose ABC transporter ATPase NP_541571.1 627707 D 224914 CDS NP_541572.1 17988939 1198366 complement(628851..629123) 1 NC_003318.1 hypothetical protein 629123 1198366 BMEII0594 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541572.1 628851 R 224914 CDS NP_541573.1 17988940 1198367 629062..629346 1 NC_003318.1 hypothetical protein 629346 1198367 BMEII0595 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541573.1 629062 D 224914 CDS NP_541574.1 17988941 1198368 629390..630799 1 NC_003318.1 methylenomycin A resistance protein 630799 1198368 BMEII0596 Brucella melitensis bv. 1 str. 16M methylenomycin A resistance protein NP_541574.1 629390 D 224914 CDS NP_541575.1 17988942 1198369 complement(630998..631720) 1 NC_003318.1 23S ribsomal RNA methyltransferase 631720 1198369 BMEII0597 Brucella melitensis bv. 1 str. 16M 23S ribsomal RNA methyltransferase NP_541575.1 630998 R 224914 CDS NP_541576.1 17988943 1198370 complement(631722..633143) 1 NC_003318.1 exopolyphosphatase 633143 1198370 BMEII0598 Brucella melitensis bv. 1 str. 16M exopolyphosphatase NP_541576.1 631722 R 224914 CDS NP_541577.1 17988944 1198371 complement(633460..634221) 1 NC_003318.1 cystine transport ATP-binding protein 634221 1198371 BMEII0599 Brucella melitensis bv. 1 str. 16M cystine transport ATP-binding protein NP_541577.1 633460 R 224914 CDS NP_541578.1 17988945 1198372 complement(634218..634952) 1 NC_003318.1 cystine transport system permease 634952 1198372 BMEII0600 Brucella melitensis bv. 1 str. 16M cystine transport system permease NP_541578.1 634218 R 224914 CDS NP_541579.1 17988946 1198373 complement(635078..635851) 1 NC_003318.1 cystine-binding periplasmic protein precursor 635851 1198373 BMEII0601 Brucella melitensis bv. 1 str. 16M cystine-binding periplasmic protein precursor NP_541579.1 635078 R 224914 CDS NP_541580.1 17988947 1198374 complement(636137..639763) 1 NC_003318.1 N-methylhydantoinase (ATP-hydrolyzing) / 5-oxoprolinase 639763 1198374 BMEII0602 Brucella melitensis bv. 1 str. 16M N-methylhydantoinase (ATP-hydrolyzing) / 5-oxoprolinase NP_541580.1 636137 R 224914 CDS NP_541581.1 17988948 1198375 639886..640485 1 NC_003318.1 hypothetical protein 640485 1198375 BMEII0603 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541581.1 639886 D 224914 CDS NP_541582.1 17988949 1198376 complement(640538..641296) 1 NC_003318.1 IRON(III) dicitrate transport ATP-binding protein FECE 641296 1198376 BMEII0604 Brucella melitensis bv. 1 str. 16M IRON(III) dicitrate transport ATP-binding protein FECE NP_541582.1 640538 R 224914 CDS NP_541583.1 17988950 1198377 complement(641293..642246) 1 NC_003318.1 ferric anguibactin transport system permease FATC 642246 1198377 BMEII0605 Brucella melitensis bv. 1 str. 16M ferric anguibactin transport system permease FATC NP_541583.1 641293 R 224914 CDS NP_541584.1 17988951 1198378 complement(642239..643165) 1 NC_003318.1 ferric anguibactin transport system permease FATD 643165 1198378 BMEII0606 Brucella melitensis bv. 1 str. 16M ferric anguibactin transport system permease FATD NP_541584.1 642239 R 224914 CDS NP_541585.1 17988952 1198379 complement(643258..644139) 1 NC_003318.1 ferric anguibactin-binding protein 644139 1198379 BMEII0607 Brucella melitensis bv. 1 str. 16M ferric anguibactin-binding protein NP_541585.1 643258 R 224914 CDS NP_541586.1 17988953 1198380 complement(644683..645972) 1 NC_003318.1 aldehyde dehydrogenase 645972 1198380 BMEII0608 Brucella melitensis bv. 1 str. 16M aldehyde dehydrogenase NP_541586.1 644683 R 224914 CDS NP_541587.1 17988954 1198381 complement(646255..646779) 1 NC_003318.1 hypothetical protein 646779 1198381 BMEII0609 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541587.1 646255 R 224914 CDS NP_541588.1 17988955 1198382 complement(646788..648380) 1 NC_003318.1 proposed role in polysaccahride synthesis; FAD-binding dehydrogenase 648380 1198382 BMEII0610 Brucella melitensis bv. 1 str. 16M FAD-binding dehydrogenase NP_541588.1 646788 R 224914 CDS NP_541589.1 17988956 1198383 complement(648515..649276) 1 NC_003318.1 hypothetical protein 649276 1198383 BMEII0611 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541589.1 648515 R 224914 CDS NP_541590.1 17988957 1198384 complement(649449..649928) 1 NC_003318.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; aminotransferase 649928 1198384 BMEII0612 Brucella melitensis bv. 1 str. 16M aminotransferase NP_541590.1 649449 R 224914 CDS NP_541591.1 17988958 1198385 complement(649939..650415) 1 NC_003318.1 branched-chain amino acid aminotransferase 650415 1198385 BMEII0613 Brucella melitensis bv. 1 str. 16M branched-chain amino acid aminotransferase NP_541591.1 649939 R 224914 CDS NP_541592.1 17988959 1198386 complement(650342..651259) 1 NC_003318.1 transporter, DME family 651259 1198386 BMEII0614 Brucella melitensis bv. 1 str. 16M transporter, DME family NP_541592.1 650342 R 224914 CDS NP_541593.1 17988960 1198387 651339..651605 1 NC_003318.1 hypothetical protein 651605 1198387 BMEII0615 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541593.1 651339 D 224914 CDS NP_541594.1 17988961 1198388 652005..652493 1 NC_003318.1 hypothetical protein 652493 1198388 BMEII0616 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541594.1 652005 D 224914 CDS NP_541595.1 17988962 1198389 652862..653707 1 NC_003318.1 xanthine/uracil permease 653707 1198389 BMEII0617 Brucella melitensis bv. 1 str. 16M xanthine/uracil permease NP_541595.1 652862 D 224914 CDS NP_541596.1 17988963 1198390 653774..654223 1 NC_003318.1 xanthine/uracil permease 654223 1198390 BMEII0618 Brucella melitensis bv. 1 str. 16M xanthine/uracil permease NP_541596.1 653774 D 224914 CDS NP_541597.1 17988964 1198391 654285..654884 1 NC_003318.1 deoxycytidylate deaminase 654884 1198391 BMEII0619 Brucella melitensis bv. 1 str. 16M deoxycytidylate deaminase NP_541597.1 654285 D 224914 CDS NP_541598.1 17988965 1198392 complement(655088..656734) 1 NC_003318.1 sulfur deprivation response regulator 656734 1198392 BMEII0620 Brucella melitensis bv. 1 str. 16M sulfur deprivation response regulator NP_541598.1 655088 R 224914 CDS NP_541599.1 17988966 1198393 complement(656996..658051) 1 NC_003318.1 part of the UgpABCE glycerol-3-phosphate uptake system; glycerol-3-phosphate transporter ATP-binding subunit 658051 ugpC 1198393 ugpC Brucella melitensis bv. 1 str. 16M glycerol-3-phosphate transporter ATP-binding subunit NP_541599.1 656996 R 224914 CDS NP_541600.1 17988967 1198394 complement(658051..658551) 1 NC_003318.1 SN-glycerol-3-phosphate transport system permease UGPE 658551 1198394 BMEII0622 Brucella melitensis bv. 1 str. 16M SN-glycerol-3-phosphate transport system permease UGPE NP_541600.1 658051 R 224914 CDS NP_541601.1 17988968 1198395 complement(658548..658898) 1 NC_003318.1 SN-glycerol-3-phosphate transport system permease UGPE 658898 1198395 BMEII0623 Brucella melitensis bv. 1 str. 16M SN-glycerol-3-phosphate transport system permease UGPE NP_541601.1 658548 R 224914 CDS NP_541602.1 17988969 1198396 complement(658910..659665) 1 NC_003318.1 SN-glycerol-3-phosphate transport system permease UGPA 659665 1198396 BMEII0624 Brucella melitensis bv. 1 str. 16M SN-glycerol-3-phosphate transport system permease UGPA NP_541602.1 658910 R 224914 CDS NP_541603.1 17988970 1198397 complement(659855..661189) 1 NC_003318.1 glycerol-3-phosphate-binding periplasmic protein precursor 661189 1198397 BMEII0625 Brucella melitensis bv. 1 str. 16M glycerol-3-phosphate-binding periplasmic protein precursor NP_541603.1 659855 R 224914 CDS NP_541604.1 17988971 1198398 complement(661489..662529) 1 NC_003318.1 membrane dipeptidase 662529 1198398 BMEII0626 Brucella melitensis bv. 1 str. 16M membrane dipeptidase NP_541604.1 661489 R 224914 CDS NP_541605.1 17988972 1198399 662688..664433 1 NC_003318.1 adenine deaminase 664433 1198399 BMEII0627 Brucella melitensis bv. 1 str. 16M adenine deaminase NP_541605.1 662688 D 224914 CDS NP_541606.1 17988973 1198400 complement(664434..665150) 1 NC_003318.1 high-affinity branched-chain amino acid transport ATP-binding protein LIVF 665150 1198400 BMEII0628 Brucella melitensis bv. 1 str. 16M high-affinity branched-chain amino acid transport ATP-binding protein LIVF NP_541606.1 664434 R 224914 CDS NP_541607.1 17988974 1198401 complement(665147..665896) 1 NC_003318.1 high-affinity branched-chain amino acid transport ATP-binding protein LIVG 665896 1198401 BMEII0629 Brucella melitensis bv. 1 str. 16M high-affinity branched-chain amino acid transport ATP-binding protein LIVG NP_541607.1 665147 R 224914 CDS NP_541608.1 17988975 1198402 complement(665880..666314) 1 NC_003318.1 high-affinity branched-chain amino acid transport ATP-binding protein LIVG 666314 1198402 BMEII0630 Brucella melitensis bv. 1 str. 16M high-affinity branched-chain amino acid transport ATP-binding protein LIVG NP_541608.1 665880 R 224914 CDS NP_541609.1 17988976 1198403 complement(666431..666880) 1 NC_003318.1 high-affinity branched-chain amino acid transport system permease LIVM 666880 1198403 BMEII0631 Brucella melitensis bv. 1 str. 16M high-affinity branched-chain amino acid transport system permease LIVM NP_541609.1 666431 R 224914 CDS NP_541610.1 17988977 1198404 complement(666877..667746) 1 NC_003318.1 high-affinity branched-chain amino acid transport system permease livH 667746 1198404 BMEII0632 Brucella melitensis bv. 1 str. 16M high-affinity branched-chain amino acid transport system permease livH NP_541610.1 666877 R 224914 CDS NP_541611.1 17988978 1198405 complement(667918..669021) 1 NC_003318.1 leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein precursor 669021 1198405 BMEII0633 Brucella melitensis bv. 1 str. 16M leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein precursor NP_541611.1 667918 R 224914 CDS NP_541612.1 17988979 1198406 complement(669226..670290) 1 NC_003318.1 Catalyzes the cycloisomerization of cis,cis-muconate; 3-carboxy-cis,cis-muconate cycloisomerase 670290 1198406 BMEII0634 Brucella melitensis bv. 1 str. 16M 3-carboxy-cis,cis-muconate cycloisomerase NP_541612.1 669226 R 224914 CDS NP_541613.1 17988980 1198407 complement(670294..670938) 1 NC_003318.1 protocatechuate 3,4-dioxygenase alpha chain 670938 1198407 BMEII0635 Brucella melitensis bv. 1 str. 16M protocatechuate 3,4-dioxygenase alpha chain NP_541613.1 670294 R 224914 CDS NP_541614.1 17988981 1198408 complement(670913..671482) 1 NC_003318.1 protocatechuate 3,4-dioxygenase subunit beta 671482 1198408 BMEII0636 Brucella melitensis bv. 1 str. 16M protocatechuate 3,4-dioxygenase subunit beta NP_541614.1 670913 R 224914 CDS NP_541615.1 17988982 1198409 complement(671650..672066) 1 NC_003318.1 4-carboxymuconolactone decarboxylase 672066 1198409 BMEII0637 Brucella melitensis bv. 1 str. 16M 4-carboxymuconolactone decarboxylase NP_541615.1 671650 R 224914 CDS NP_541616.1 17988983 1198410 complement(672070..672873) 1 NC_003318.1 3-oxoadipate enol-lactonase 672873 1198410 BMEII0638 Brucella melitensis bv. 1 str. 16M 3-oxoadipate enol-lactonase NP_541616.1 672070 R 224914 CDS NP_541617.1 17988984 1198411 672967..673875 1 NC_003318.1 LysR family transcriptional regulator 673875 1198411 BMEII0639 Brucella melitensis bv. 1 str. 16M LysR family transcriptional regulator NP_541617.1 672967 D 224914 CDS NP_541618.1 17988985 1198412 complement(674286..675455) 1 NC_003318.1 catalyzes the formation of protocatechuate from 4-hydroxybenzoate; 4-hydroxybenzoate 3-monooxygenase 675455 1198412 BMEII0640 Brucella melitensis bv. 1 str. 16M 4-hydroxybenzoate 3-monooxygenase NP_541618.1 674286 R 224914 CDS NP_541619.1 17988986 1198413 675562..676485 1 NC_003318.1 AraC family transcriptional regulator 676485 1198413 BMEII0641 Brucella melitensis bv. 1 str. 16M AraC family transcriptional regulator NP_541619.1 675562 D 224914 CDS NP_541620.1 17988987 1198414 complement(676492..677262) 1 NC_003318.1 pca regulon regulatory protein 677262 1198414 BMEII0642 Brucella melitensis bv. 1 str. 16M pca regulon regulatory protein NP_541620.1 676492 R 224914 CDS NP_541621.1 17988988 1198415 677299..677829 1 NC_003318.1 3-oxoadipate CoA-transferase subunit A 677829 1198415 BMEII0643 Brucella melitensis bv. 1 str. 16M 3-oxoadipate CoA-transferase subunit A NP_541621.1 677299 D 224914 CDS NP_541622.1 17988989 1198416 677729..678154 1 NC_003318.1 3-oxoadipate CoA-transferase subunit A 678154 1198416 BMEII0644 Brucella melitensis bv. 1 str. 16M 3-oxoadipate CoA-transferase subunit A NP_541622.1 677729 D 224914 CDS NP_541623.1 17988990 1198417 678151..678840 1 NC_003318.1 3-oxoadipate CoA-transferase subunit B 678840 1198417 BMEII0645 Brucella melitensis bv. 1 str. 16M 3-oxoadipate CoA-transferase subunit B NP_541623.1 678151 D 224914 CDS NP_541624.1 17988991 1198418 678837..679202 1 NC_003318.1 acetyl-COA acetyltransferase 679202 1198418 BMEII0646 Brucella melitensis bv. 1 str. 16M acetyl-COA acetyltransferase NP_541624.1 678837 D 224914 CDS NP_541625.1 17988992 1198419 679354..679623 1 NC_003318.1 hypothetical protein 679623 1198419 BMEII0647 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541625.1 679354 D 224914 CDS NP_541626.1 17988993 1198420 680207..680614 1 NC_003318.1 AraC family transcriptional regulator 680614 1198420 BMEII0648 Brucella melitensis bv. 1 str. 16M AraC family transcriptional regulator NP_541626.1 680207 D 224914 CDS NP_541627.1 17988994 1198421 complement(680715..680996) 1 NC_003318.1 hypothetical protein 680996 1198421 BMEII0649 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541627.1 680715 R 224914 CDS NP_541628.1 17988995 1198422 complement(681372..682073) 1 NC_003318.1 DNA polymerase III, epsilon chain 682073 1198422 BMEII0650 Brucella melitensis bv. 1 str. 16M DNA polymerase III, epsilon chain NP_541628.1 681372 R 224914 CDS NP_541629.1 17988996 1198423 complement(682140..682433) 1 NC_003318.1 hypothetical protein 682433 1198423 BMEII0651 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541629.1 682140 R 224914 CDS NP_541630.1 17988997 1198424 complement(682817..683137) 1 NC_003318.1 hypothetical protein 683137 1198424 BMEII0652 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541630.1 682817 R 224914 CDS NP_541631.1 17988998 1198425 683263..683640 1 NC_003318.1 endonuclease V 683640 1198425 BMEII0653 Brucella melitensis bv. 1 str. 16M endonuclease V NP_541631.1 683263 D 224914 CDS NP_541632.1 17988999 1198426 684623..685261 1 NC_003318.1 diguanylate cyclase/phosphodiesterase 685261 1198426 BMEII0654 Brucella melitensis bv. 1 str. 16M diguanylate cyclase/phosphodiesterase NP_541632.1 684623 D 224914 CDS NP_541633.1 17989000 1198427 complement(685790..687979) 1 NC_003318.1 alkaline phosphatase 687979 1198427 BMEII0655 Brucella melitensis bv. 1 str. 16M alkaline phosphatase NP_541633.1 685790 R 224914 CDS NP_541634.1 17989001 1198428 complement(688150..689487) 1 NC_003318.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 689487 1198428 BMEII0656 Brucella melitensis bv. 1 str. 16M DNA polymerase IV NP_541634.1 688150 R 224914 CDS NP_541635.1 17989002 1198429 689938..690243 1 NC_003318.1 regulator of nucleoside diphosphate kinase 690243 1198429 BMEII0657 Brucella melitensis bv. 1 str. 16M regulator of nucleoside diphosphate kinase NP_541635.1 689938 D 224914 CDS NP_541636.1 17989003 1198430 complement(690502..690837) 1 NC_003318.1 hypothetical protein 690837 1198430 BMEII0658 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541636.1 690502 R 224914 CDS NP_541637.1 17989004 1198431 690970..691341 1 NC_003318.1 two component response regulator 691341 1198431 BMEII0659 Brucella melitensis bv. 1 str. 16M two component response regulator NP_541637.1 690970 D 224914 CDS NP_541638.1 17989005 1198432 691462..692847 1 NC_003318.1 involved in swarmer-to-stalked cell differentiation in Caulobacter crescentus; catalyzes the condensation of two GTP molecules to form the secondary messenger cyclic di-GMP (c-di-GMP); upon phosphorylation of domain D1 the protein dimerizes; presumably this allows the two GTP-bound GGDEF (diguanylate cyclase) domains to catalyze the condensation reaction; allosterically inhibited by c-di-GMP; response regulator PleD 692847 pleD 1198432 pleD Brucella melitensis bv. 1 str. 16M response regulator PleD NP_541638.1 691462 D 224914 CDS NP_541639.1 17989006 1198433 complement(692954..693121) 1 NC_003318.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 693121 rpmG 1198433 rpmG Brucella melitensis bv. 1 str. 16M 50S ribosomal protein L33 NP_541639.1 692954 R 224914 CDS NP_541640.1 17989007 1198434 complement(693280..694422) 1 NC_003318.1 major facilitator transporter 694422 1198434 BMEII0662 Brucella melitensis bv. 1 str. 16M major facilitator transporter NP_541640.1 693280 R 224914 CDS NP_541641.1 17989008 1198435 complement(694497..695240) 1 NC_003318.1 phosphohydrolase (MUTT/NUDIX family protein) 695240 1198435 BMEII0663 Brucella melitensis bv. 1 str. 16M phosphohydrolase (MUTT/NUDIX family protein) NP_541641.1 694497 R 224914 CDS NP_541642.1 17989009 1198436 complement(695237..695824) 1 NC_003318.1 hypothetical protein 695824 1198436 BMEII0664 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541642.1 695237 R 224914 CDS NP_541643.1 17989010 1198437 complement(695697..698048) 1 NC_003318.1 ribonuclease R 698048 1198437 BMEII0665 Brucella melitensis bv. 1 str. 16M ribonuclease R NP_541643.1 695697 R 224914 CDS NP_541644.1 17989011 1198438 complement(698052..700757) 1 NC_003318.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 700757 1198438 BMEII0666 Brucella melitensis bv. 1 str. 16M DNA topoisomerase I NP_541644.1 698052 R 224914 CDS NP_541645.1 17989012 1198439 complement(701118..702299) 1 NC_003318.1 SMF protein 702299 1198439 BMEII0667 Brucella melitensis bv. 1 str. 16M SMF protein NP_541645.1 701118 R 224914 CDS NP_541646.1 17989013 1198440 complement(702296..702901) 1 NC_003318.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; glycerol-3-phosphate acyltransferase PlsY 702901 1198440 BMEII0668 Brucella melitensis bv. 1 str. 16M glycerol-3-phosphate acyltransferase PlsY NP_541646.1 702296 R 224914 CDS NP_541647.1 17989014 1198441 complement(702976..704262) 1 NC_003318.1 Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides; dihydroorotase 704262 1198441 BMEII0669 Brucella melitensis bv. 1 str. 16M dihydroorotase NP_541647.1 702976 R 224914 CDS NP_541648.1 17989015 1198442 complement(704259..705227) 1 NC_003318.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase 705227 pyrB 1198442 pyrB Brucella melitensis bv. 1 str. 16M aspartate carbamoyltransferase NP_541648.1 704259 R 224914 CDS NP_541649.1 17989016 1198443 705384..707039 1 NC_003318.1 acyl-CoA dehydrogenase 707039 1198443 BMEII0671 Brucella melitensis bv. 1 str. 16M acyl-CoA dehydrogenase NP_541649.1 705384 D 224914 CDS NP_541650.1 17989017 1198444 complement(707024..707512) 1 NC_003318.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 707512 1198444 BMEII0672 Brucella melitensis bv. 1 str. 16M Holliday junction resolvase-like protein NP_541650.1 707024 R 224914 CDS NP_541651.2 161511171 1198445 707612..708325 1 NC_003318.1 catalyzes the opening and hydrolysis of the beta-lactam ring of beta-lactam antibiotics such as penicillins and cephalosporins; metal-dependent hydrolase 708325 1198445 BMEII0673 Brucella melitensis bv. 1 str. 16M metal-dependent hydrolase NP_541651.2 707612 D 224914 CDS NP_541652.1 17989019 1198446 708420..708707 1 NC_003318.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain; aspartyl/glutamyl-tRNA amidotransferase subunit C 708707 gatC 1198446 gatC Brucella melitensis bv. 1 str. 16M aspartyl/glutamyl-tRNA amidotransferase subunit C NP_541652.1 708420 D 224914 CDS NP_541653.1 17989020 1198447 708760..710247 1 NC_003318.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A 710247 gatA 1198447 gatA Brucella melitensis bv. 1 str. 16M aspartyl/glutamyl-tRNA amidotransferase subunit A NP_541653.1 708760 D 224914 CDS NP_541654.1 17989021 1198448 complement(710669..712768) 1 NC_003318.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 712768 1198448 BMEII0676 Brucella melitensis bv. 1 str. 16M DNA topoisomerase IV subunit B NP_541654.1 710669 R 224914 CDS NP_541655.1 17989022 1198449 713073..714002 1 NC_003318.1 transporter, DME family 714002 1198449 BMEII0677 Brucella melitensis bv. 1 str. 16M transporter, DME family NP_541655.1 713073 D 224914 CDS NP_541656.1 17989023 1198450 complement(714006..714800) 1 NC_003318.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B 714800 lipB 1198450 lipB Brucella melitensis bv. 1 str. 16M lipoate-protein ligase B NP_541656.1 714006 R 224914 CDS NP_541657.1 17989024 1198451 complement(714928..716397) 1 NC_003318.1 sensory transduction histidine kinase 716397 1198451 BMEII0679 Brucella melitensis bv. 1 str. 16M sensory transduction histidine kinase NP_541657.1 714928 R 224914 CDS NP_541658.1 17989025 1198452 717119..717367 1 NC_003318.1 hypothetical protein 717367 1198452 BMEII0680 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541658.1 717119 D 224914 CDS NP_541659.1 17989026 1198453 complement(717641..719053) 1 NC_003318.1 virulence protein 719053 1198453 BMEII0681 Brucella melitensis bv. 1 str. 16M virulence protein NP_541659.1 717641 R 224914 CDS NP_541660.1 17989027 1198454 complement(719050..721668) 1 NC_003318.1 oxacillin resistance-associated protein FMTC 721668 1198454 BMEII0682 Brucella melitensis bv. 1 str. 16M oxacillin resistance-associated protein FMTC NP_541660.1 719050 R 224914 CDS NP_541661.1 17989028 1198455 721841..722602 1 NC_003318.1 cytochrome C-type biogenesis protein CCDA 722602 1198455 BMEII0683 Brucella melitensis bv. 1 str. 16M cytochrome C-type biogenesis protein CCDA NP_541661.1 721841 D 224914 CDS NP_541662.1 17989029 1198456 722642..724048 1 NC_003318.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 724048 glmU 1198456 glmU Brucella melitensis bv. 1 str. 16M bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase NP_541662.1 722642 D 224914 CDS NP_541663.1 17989030 1198457 724137..725975 1 NC_003318.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 725975 1198457 BMEII0685 Brucella melitensis bv. 1 str. 16M glucosamine--fructose-6-phosphate aminotransferase NP_541663.1 724137 D 224914 CDS NP_541664.1 17989031 1198458 complement(726130..728274) 1 NC_003318.1 catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 728274 1198458 BMEII0686 Brucella melitensis bv. 1 str. 16M ATP-dependent DNA helicase RecG NP_541664.1 726130 R 224914 CDS NP_541665.1 17989032 1198459 728389..728682 1 NC_003318.1 cytoplasmic protein 728682 1198459 BMEII0687 Brucella melitensis bv. 1 str. 16M cytoplasmic protein NP_541665.1 728389 D 224914 CDS NP_541666.1 17989033 1198460 728693..732205 1 NC_003318.1 transcription-repair coupling factor 732205 1198460 BMEII0688 Brucella melitensis bv. 1 str. 16M transcription-repair coupling factor NP_541666.1 728693 D 224914 CDS NP_541667.1 17989034 1198461 732277..732696 1 NC_003318.1 fosfomycin resistance protein 732696 1198461 BMEII0689 Brucella melitensis bv. 1 str. 16M fosfomycin resistance protein NP_541667.1 732277 D 224914 CDS NP_541668.1 17989035 1198462 complement(732874..733548) 1 NC_003318.1 FRNE 733548 1198462 BMEII0690 Brucella melitensis bv. 1 str. 16M FRNE NP_541668.1 732874 R 224914 CDS NP_541669.1 17989036 1198463 complement(733718..735562) 1 NC_003318.1 periplasmic oligopeptide-binding protein precursor 735562 1198463 BMEII0691 Brucella melitensis bv. 1 str. 16M periplasmic oligopeptide-binding protein precursor NP_541669.1 733718 R 224914 CDS NP_541670.1 17989037 1198464 735964..736527 1 NC_003318.1 hypothetical protein 736527 1198464 BMEII0692 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541670.1 735964 D 224914 CDS NP_541671.1 17989038 1198465 complement(736660..736998) 1 NC_003318.1 cytoplasmic protein 736998 1198465 BMEII0693 Brucella melitensis bv. 1 str. 16M cytoplasmic protein NP_541671.1 736660 R 224914 CDS NP_541672.1 17989039 1198466 complement(737071..738429) 1 NC_003318.1 2-octaprenyl-6-methoxyphenyl hydroxylase 738429 1198466 BMEII0694 Brucella melitensis bv. 1 str. 16M 2-octaprenyl-6-methoxyphenyl hydroxylase NP_541672.1 737071 R 224914 CDS NP_541673.1 17989040 1198467 738645..739445 1 NC_003318.1 phosphatidylcholine synthase 739445 1198467 BMEII0695 Brucella melitensis bv. 1 str. 16M phosphatidylcholine synthase NP_541673.1 738645 D 224914 CDS NP_541674.1 17989041 1198468 739442..740158 1 NC_003318.1 quinone oxidoreductase 740158 1198468 BMEII0696 Brucella melitensis bv. 1 str. 16M quinone oxidoreductase NP_541674.1 739442 D 224914 CDS NP_541675.1 17989042 1198469 740234..740416 1 NC_003318.1 quinone oxidoreductase 740416 1198469 BMEII0697 Brucella melitensis bv. 1 str. 16M quinone oxidoreductase NP_541675.1 740234 D 224914 CDS NP_541676.1 17989043 1198470 740520..742082 1 NC_003318.1 sugar transport ATP-binding protein 742082 1198470 BMEII0698 Brucella melitensis bv. 1 str. 16M sugar transport ATP-binding protein NP_541676.1 740520 D 224914 CDS NP_541677.1 17989044 1198471 742079..743080 1 NC_003318.1 galactoside transport system permease mglC 743080 1198471 BMEII0699 Brucella melitensis bv. 1 str. 16M galactoside transport system permease mglC NP_541677.1 742079 D 224914 CDS NP_541678.1 17989045 1198472 742981..743163 1 NC_003318.1 galactoside transport system permease mglC 743163 1198472 BMEII0700 Brucella melitensis bv. 1 str. 16M galactoside transport system permease mglC NP_541678.1 742981 D 224914 CDS NP_541679.1 17989046 1198473 743174..744088 1 NC_003318.1 ribose ABC transporter permease 744088 1198473 BMEII0701 Brucella melitensis bv. 1 str. 16M ribose ABC transporter permease NP_541679.1 743174 D 224914 CDS NP_541680.1 17989047 1198474 744147..745238 1 NC_003318.1 ABC transporter periplasmic-binding protein 745238 1198474 BMEII0702 Brucella melitensis bv. 1 str. 16M ABC transporter periplasmic-binding protein NP_541680.1 744147 D 224914 CDS NP_541681.1 17989048 1198475 complement(745378..746691) 1 NC_003318.1 catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit; ribosomal protein S12 methylthiotransferase 746691 rimO 1198475 rimO Brucella melitensis bv. 1 str. 16M ribosomal protein S12 methylthiotransferase NP_541681.1 745378 R 224914 CDS NP_541682.1 17989049 1198476 complement(746855..747340) 1 NC_003318.1 bacterioferritin 747340 1198476 BMEII0704 Brucella melitensis bv. 1 str. 16M bacterioferritin NP_541682.1 746855 R 224914 CDS NP_541683.1 17989050 1198477 complement(747306..747617) 1 NC_003318.1 hypothetical protein 747617 1198477 BMEII0705 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541683.1 747306 R 224914 CDS NP_541684.1 17989051 1198478 complement(748073..748387) 1 NC_003318.1 cytoplasmic protein 748387 1198478 BMEII0706 Brucella melitensis bv. 1 str. 16M cytoplasmic protein NP_541684.1 748073 R 224914 CDS NP_541685.1 17989052 1198479 complement(748504..748965) 1 NC_003318.1 rhizobial iron regulator; in Sinorhizobium meliloti mutations in this gene affect the expression of a number of iron-responsive operons; iron-responsive transcriptional regulator 748965 rirA 1198479 rirA Brucella melitensis bv. 1 str. 16M iron-responsive transcriptional regulator NP_541685.1 748504 R 224914 CDS NP_541686.1 17989053 1198480 complement(749211..749669) 1 NC_003318.1 prolyl-tRNA synthetase 749669 1198480 BMEII0708 Brucella melitensis bv. 1 str. 16M prolyl-tRNA synthetase NP_541686.1 749211 R 224914 CDS NP_541687.1 17989054 1198481 complement(750142..750504) 1 NC_003318.1 hypothetical protein 750504 1198481 BMEII0709 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541687.1 750142 R 224914 CDS NP_541688.1 17989055 1198482 751312..751677 1 NC_003318.1 transposase 751677 1198482 BMEII0710 Brucella melitensis bv. 1 str. 16M transposase NP_541688.1 751312 D 224914 CDS NP_541689.1 17989056 1198483 751764..752225 1 NC_003318.1 transposase 752225 1198483 BMEII0711 Brucella melitensis bv. 1 str. 16M transposase NP_541689.1 751764 D 224914 CDS NP_541690.1 17989057 1198484 752222..752575 1 NC_003318.1 transcriptional regulator 752575 1198484 BMEII0712 Brucella melitensis bv. 1 str. 16M transcriptional regulator NP_541690.1 752222 D 224914 CDS NP_541691.1 17989058 1198485 752625..753743 1 NC_003318.1 transposase 753743 1198485 BMEII0713 Brucella melitensis bv. 1 str. 16M transposase NP_541691.1 752625 D 224914 CDS NP_541692.1 17989059 1198486 complement(753510..754271) 1 NC_003318.1 transposase 754271 1198486 BMEII0714 Brucella melitensis bv. 1 str. 16M transposase NP_541692.1 753510 R 224914 CDS NP_541693.1 17989060 1198487 754193..754798 1 NC_003318.1 preprotein translocase subunit-like protein 754798 1198487 BMEII0715 Brucella melitensis bv. 1 str. 16M preprotein translocase subunit-like protein NP_541693.1 754193 D 224914 CDS NP_541694.1 17989061 1198488 755120..755281 1 NC_003318.1 transposase 755281 1198488 BMEII0716 Brucella melitensis bv. 1 str. 16M transposase NP_541694.1 755120 D 224914 CDS NP_541695.1 17989062 1198489 755374..757398 1 NC_003318.1 hemagglutinin 757398 1198489 BMEII0717 Brucella melitensis bv. 1 str. 16M hemagglutinin NP_541695.1 755374 D 224914 CDS NP_541696.1 17989063 1198490 757373..757741 1 NC_003318.1 transposase 757741 1198490 BMEII0718 Brucella melitensis bv. 1 str. 16M transposase NP_541696.1 757373 D 224914 CDS NP_541697.1 17989064 1198491 757738..758016 1 NC_003318.1 transposase 758016 1198491 BMEII0719 Brucella melitensis bv. 1 str. 16M transposase NP_541697.1 757738 D 224914 CDS NP_541698.1 17989065 1198492 758549..758758 1 NC_003318.1 transcriptional regulator 758758 1198492 BMEII0720 Brucella melitensis bv. 1 str. 16M transcriptional regulator NP_541698.1 758549 D 224914 CDS NP_541699.1 17989066 1198493 758809..759720 1 NC_003318.1 AraC family transcriptional regulator 759720 1198493 BMEII0721 Brucella melitensis bv. 1 str. 16M AraC family transcriptional regulator NP_541699.1 758809 D 224914 CDS NP_541700.1 17989067 1198494 759754..760080 1 NC_003318.1 hypothetical protein 760080 1198494 BMEII0722 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541700.1 759754 D 224914 CDS NP_541701.1 17989068 1198495 complement(760197..760814) 1 NC_003318.1 hypothetical protein 760814 1198495 BMEII0723 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541701.1 760197 R 224914 CDS NP_541702.1 17989069 1198496 complement(760811..761542) 1 NC_003318.1 endoglucanase H 761542 1198496 BMEII0724 Brucella melitensis bv. 1 str. 16M endoglucanase H NP_541702.1 760811 R 224914 CDS NP_541703.1 17989070 1198497 complement(761512..761793) 1 NC_003318.1 hypothetical protein 761793 1198497 BMEII0725 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541703.1 761512 R 224914 CDS NP_541704.1 17989071 1198498 complement(761804..762349) 1 NC_003318.1 hypothetical protein 762349 1198498 BMEII0726 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541704.1 761804 R 224914 CDS NP_541705.1 17989072 1198499 complement(762339..763763) 1 NC_003318.1 UDP-glucose 6-dehydrogenase 763763 1198499 BMEII0727 Brucella melitensis bv. 1 str. 16M UDP-glucose 6-dehydrogenase NP_541705.1 762339 R 224914 CDS NP_541706.1 17989073 1198500 complement(763778..765196) 1 NC_003318.1 cellulose synthase catalytic subunit (UDP-forming) 765196 1198500 BMEII0728 Brucella melitensis bv. 1 str. 16M cellulose synthase catalytic subunit (UDP-forming) NP_541706.1 763778 R 224914 CDS NP_541707.1 17989074 1198501 complement(764974..765570) 1 NC_003318.1 cellulose synthase catalytic subunit (UDP-forming) 765570 1198501 BMEII0729 Brucella melitensis bv. 1 str. 16M cellulose synthase catalytic subunit (UDP-forming) NP_541707.1 764974 R 224914 CDS NP_541708.1 17989075 1198502 complement(765611..766597) 1 NC_003318.1 UDP-glucose 4-epimerase 766597 1198502 BMEII0730 Brucella melitensis bv. 1 str. 16M UDP-glucose 4-epimerase NP_541708.1 765611 R 224914 CDS NP_541709.1 17989076 1198503 complement(766597..767187) 1 NC_003318.1 dTDP-glucose 4-6-dehydratase 767187 1198503 BMEII0731 Brucella melitensis bv. 1 str. 16M dTDP-glucose 4-6-dehydratase NP_541709.1 766597 R 224914 CDS NP_541710.1 17989077 1198504 767148..767405 1 NC_003318.1 hypothetical protein 767405 1198504 BMEII0732 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541710.1 767148 D 224914 CDS NP_541711.1 17989078 1198505 767435..767782 1 NC_003318.1 hypothetical protein 767782 1198505 BMEII0733 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541711.1 767435 D 224914 CDS NP_541712.1 17989079 1198506 768278..769786 1 NC_003318.1 periplasmic oligopeptide-binding protein precursor 769786 1198506 BMEII0734 Brucella melitensis bv. 1 str. 16M periplasmic oligopeptide-binding protein precursor NP_541712.1 768278 D 224914 CDS NP_541713.1 17989080 1198507 769898..771475 1 NC_003318.1 periplasmic oligopeptide-binding protein precursor 771475 1198507 BMEII0735 Brucella melitensis bv. 1 str. 16M periplasmic oligopeptide-binding protein precursor NP_541713.1 769898 D 224914 CDS NP_541714.1 17989081 1198508 771660..772613 1 NC_003318.1 oligopeptide transport system permease OPPB 772613 1198508 BMEII0736 Brucella melitensis bv. 1 str. 16M oligopeptide transport system permease OPPB NP_541714.1 771660 D 224914 CDS NP_541715.1 17989082 1198509 772579..773739 1 NC_003318.1 oligopeptide transport system permease OPPC 773739 1198509 BMEII0737 Brucella melitensis bv. 1 str. 16M oligopeptide transport system permease OPPC NP_541715.1 772579 D 224914 CDS NP_541716.1 17989083 1198510 773696..775351 1 NC_003318.1 oligopeptide transport ATP-binding protein OPPD 775351 1198510 BMEII0738 Brucella melitensis bv. 1 str. 16M oligopeptide transport ATP-binding protein OPPD NP_541716.1 773696 D 224914 CDS NP_541717.1 17989084 1198511 775433..776071 1 NC_003318.1 alkylated DNA repair protein AlkB 776071 1198511 BMEII0739 Brucella melitensis bv. 1 str. 16M alkylated DNA repair protein AlkB NP_541717.1 775433 D 224914 CDS NP_541718.1 17989085 1198512 complement(776230..777576) 1 NC_003318.1 major facilitator transporter 777576 1198512 BMEII0740 Brucella melitensis bv. 1 str. 16M major facilitator transporter NP_541718.1 776230 R 224914 CDS NP_541719.1 17989086 1198513 777787..778809 1 NC_003318.1 D-aminopeptidase 778809 1198513 BMEII0741 Brucella melitensis bv. 1 str. 16M D-aminopeptidase NP_541719.1 777787 D 224914 CDS NP_541720.1 17989087 1198514 779980..781569 1 NC_003318.1 DNA translocase FtsK 781569 1198514 BMEII0742 Brucella melitensis bv. 1 str. 16M DNA translocase FtsK NP_541720.1 779980 D 224914 CDS NP_541721.1 17989088 1198515 782329..783024 1 NC_003318.1 surfeit locus protein 1 783024 1198515 BMEII0743 Brucella melitensis bv. 1 str. 16M surfeit locus protein 1 NP_541721.1 782329 D 224914 CDS NP_541722.1 17989089 1198516 complement(783013..783342) 1 NC_003318.1 dihydrolipoamide dehydrogenase 783342 1198516 BMEII0744 Brucella melitensis bv. 1 str. 16M dihydrolipoamide dehydrogenase NP_541722.1 783013 R 224914 CDS NP_541723.1 17989090 1198517 complement(783388..784314) 1 NC_003318.1 dihydrolipoamide dehydrogenase 784314 1198517 BMEII0745 Brucella melitensis bv. 1 str. 16M dihydrolipoamide dehydrogenase NP_541723.1 783388 R 224914 CDS NP_541724.1 17989091 1198518 complement(784412..785707) 1 NC_003318.1 Catalyzes the transfer of acetyl from acetyldihydrolipoamide to coenzyme A to form acetyl CoA; branched-chain alpha-keto acid dehydrogenase subunit E2 785707 1198518 BMEII0746 Brucella melitensis bv. 1 str. 16M branched-chain alpha-keto acid dehydrogenase subunit E2 NP_541724.1 784412 R 224914 CDS NP_541725.1 17989092 1198519 complement(785708..786721) 1 NC_003318.1 2-oxoisovalerate dehydrogenase subunit beta 786721 1198519 BMEII0747 Brucella melitensis bv. 1 str. 16M 2-oxoisovalerate dehydrogenase subunit beta NP_541725.1 785708 R 224914 CDS NP_541726.1 17989093 1198520 complement(786825..788057) 1 NC_003318.1 2-oxoisovalerate dehydrogenase subunit alpha 788057 1198520 BMEII0748 Brucella melitensis bv. 1 str. 16M 2-oxoisovalerate dehydrogenase subunit alpha NP_541726.1 786825 R 224914 CDS NP_541727.1 17989094 1198521 complement(788354..788605) 1 NC_003318.1 hypothetical protein 788605 1198521 BMEII0749 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541727.1 788354 R 224914 CDS NP_541728.1 17989095 1198522 complement(788658..789659) 1 NC_003318.1 maltose/maltodextrin transport ATP-binding protein MALK 789659 1198522 BMEII0750 Brucella melitensis bv. 1 str. 16M maltose/maltodextrin transport ATP-binding protein MALK NP_541728.1 788658 R 224914 CDS NP_541729.1 17989096 1198523 complement(789689..790624) 1 NC_003318.1 oxidoreductase 790624 1198523 BMEII0751 Brucella melitensis bv. 1 str. 16M oxidoreductase NP_541729.1 789689 R 224914 CDS NP_541730.1 17989097 1198524 complement(790756..791595) 1 NC_003318.1 maltose transport system permease MALG 791595 1198524 BMEII0752 Brucella melitensis bv. 1 str. 16M maltose transport system permease MALG NP_541730.1 790756 R 224914 CDS NP_541731.1 17989098 1198525 complement(791608..792627) 1 NC_003318.1 sorbitol/mannitol transport inner membrane protein 792627 1198525 BMEII0753 Brucella melitensis bv. 1 str. 16M sorbitol/mannitol transport inner membrane protein NP_541731.1 791608 R 224914 CDS NP_541732.1 17989099 1198526 complement(792925..793647) 1 NC_003318.1 sugar-binding protein 793647 1198526 BMEII0754 Brucella melitensis bv. 1 str. 16M sugar-binding protein NP_541732.1 792925 R 224914 CDS NP_541733.1 17989100 1198527 complement(793741..794160) 1 NC_003318.1 sugar-binding protein 794160 1198527 BMEII0755 Brucella melitensis bv. 1 str. 16M sugar-binding protein NP_541733.1 793741 R 224914 CDS NP_541734.1 17989101 1198528 794494..795420 1 NC_003318.1 N-acetylglucosamine kinase 795420 1198528 BMEII0756 Brucella melitensis bv. 1 str. 16M N-acetylglucosamine kinase NP_541734.1 794494 D 224914 CDS NP_541735.1 17989102 1198529 795411..796190 1 NC_003318.1 GntR family transcriptional regulator 796190 1198529 BMEII0757 Brucella melitensis bv. 1 str. 16M GntR family transcriptional regulator NP_541735.1 795411 D 224914 CDS NP_541736.1 17989103 1198530 complement(796241..796396) 1 NC_003318.1 hypothetical protein 796396 1198530 BMEII0758 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541736.1 796241 R 224914 CDS NP_541737.1 17989104 1198531 complement(796413..797480) 1 NC_003318.1 cytochrome D ubiquinol oxidase subunit II 797480 1198531 BMEII0759 Brucella melitensis bv. 1 str. 16M cytochrome D ubiquinol oxidase subunit II NP_541737.1 796413 R 224914 CDS NP_541738.1 17989105 1198532 complement(797571..799232) 1 NC_003318.1 cytochrome D ubiquinol oxidase subunit I 799232 1198532 BMEII0760 Brucella melitensis bv. 1 str. 16M cytochrome D ubiquinol oxidase subunit I NP_541738.1 797571 R 224914 CDS NP_541739.1 17989106 1198533 complement(799291..800964) 1 NC_003318.1 transport ATP-binding protein CYDC 800964 1198533 BMEII0761 Brucella melitensis bv. 1 str. 16M transport ATP-binding protein CYDC NP_541739.1 799291 R 224914 CDS NP_541740.1 17989107 1198534 complement(800970..802706) 1 NC_003318.1 transport ATP-binding protein CYDD 802706 1198534 BMEII0762 Brucella melitensis bv. 1 str. 16M transport ATP-binding protein CYDD NP_541740.1 800970 R 224914 CDS NP_541741.1 17989108 1198535 complement(802703..803287) 1 NC_003318.1 ArsR family transcriptional regulator 803287 1198535 BMEII0763 Brucella melitensis bv. 1 str. 16M ArsR family transcriptional regulator NP_541741.1 802703 R 224914 CDS NP_541742.1 17989109 1198536 complement(803315..803566) 1 NC_003318.1 hypothetical protein 803566 1198536 BMEII0764 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541742.1 803315 R 224914 CDS NP_541743.1 17989110 1198537 complement(803664..804026) 1 NC_003318.1 subunit G of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; monovalent cation/H+ antiporter subunit G 804026 1198537 BMEII0765 Brucella melitensis bv. 1 str. 16M monovalent cation/H+ antiporter subunit G NP_541743.1 803664 R 224914 CDS NP_541744.1 17989111 1198538 complement(804023..804304) 1 NC_003318.1 subunit F of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved specifically with K+ transport; monovalent cation/H+ antiporter subunit F 804304 phaF 1198538 phaF Brucella melitensis bv. 1 str. 16M monovalent cation/H+ antiporter subunit F NP_541744.1 804023 R 224914 CDS NP_541745.1 17989112 1198539 complement(804301..804816) 1 NC_003318.1 subunit E of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; monovalent cation/H+ antiporter subunit E 804816 1198539 BMEII0767 Brucella melitensis bv. 1 str. 16M monovalent cation/H+ antiporter subunit E NP_541745.1 804301 R 224914 CDS NP_541746.1 17989113 1198540 complement(804813..806441) 1 NC_003318.1 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone; monovalent cation/H+ antiporter subunit D 806441 1198540 BMEII0768 Brucella melitensis bv. 1 str. 16M monovalent cation/H+ antiporter subunit D NP_541746.1 804813 R 224914 CDS NP_541747.1 17989114 1198541 complement(806444..806782) 1 NC_003318.1 subunit C of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; monovalent cation/H+ antiporter subunit C 806782 1198541 BMEII0769 Brucella melitensis bv. 1 str. 16M monovalent cation/H+ antiporter subunit C NP_541747.1 806444 R 224914 CDS NP_541748.1 17989115 1198542 complement(806782..809694) 1 NC_003318.1 subunit A of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved with K+; monovalent cation/H+ antiporter subunit A 809694 1198542 BMEII0770 Brucella melitensis bv. 1 str. 16M monovalent cation/H+ antiporter subunit A NP_541748.1 806782 R 224914 CDS NP_541749.1 17989116 1198543 complement(810141..811469) 1 NC_003318.1 hydroxyacylglutathione hydrolase 811469 1198543 BMEII0771 Brucella melitensis bv. 1 str. 16M hydroxyacylglutathione hydrolase NP_541749.1 810141 R 224914 CDS NP_541750.1 17989117 1198544 811793..812392 1 NC_003318.1 cytoplasmic protein 812392 1198544 BMEII0772 Brucella melitensis bv. 1 str. 16M cytoplasmic protein NP_541750.1 811793 D 224914 CDS NP_541751.1 17989118 1198545 complement(812444..812962) 1 NC_003318.1 forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MogA 812962 mogA 1198545 mogA Brucella melitensis bv. 1 str. 16M molybdenum cofactor biosynthesis protein MogA NP_541751.1 812444 R 224914 CDS NP_541752.1 17989119 1198546 813225..813506 1 NC_003318.1 hypothetical protein 813506 1198546 BMEII0774 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541752.1 813225 D 224914 CDS NP_541753.1 17989120 1198547 813862..814902 1 NC_003318.1 biotin synthase 814902 1198547 BMEII0775 Brucella melitensis bv. 1 str. 16M biotin synthase NP_541753.1 813862 D 224914 CDS NP_541754.1 17989121 1198548 814899..816035 1 NC_003318.1 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase 816035 1198548 BMEII0776 Brucella melitensis bv. 1 str. 16M 8-amino-7-oxononanoate synthase NP_541754.1 814899 D 224914 CDS NP_541755.1 17989122 1198549 816032..816670 1 NC_003318.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 816670 bioD 1198549 bioD Brucella melitensis bv. 1 str. 16M dithiobiotin synthetase NP_541755.1 816032 D 224914 CDS NP_541756.1 17989123 1198550 816667..817941 1 NC_003318.1 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine-8-amino-7-oxononanoate aminotransferase 817941 1198550 BMEII0778 Brucella melitensis bv. 1 str. 16M adenosylmethionine-8-amino-7-oxononanoate aminotransferase NP_541756.1 816667 D 224914 CDS NP_541757.1 17989124 1198551 817938..818918 1 NC_003318.1 FabF, beta-Ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 818918 1198551 BMEII0779 Brucella melitensis bv. 1 str. 16M 3-oxoacyl-ACP synthase NP_541757.1 817938 D 224914 CDS NP_541758.1 17989125 1198552 complement(819147..819536) 1 NC_003318.1 hypothetical protein 819536 1198552 BMEII0780 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541758.1 819147 R 224914 CDS NP_541759.2 161511170 1198553 819762..820682 1 NC_003318.1 catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis; homoserine O-succinyltransferase 820682 1198553 BMEII0781 Brucella melitensis bv. 1 str. 16M homoserine O-succinyltransferase NP_541759.2 819762 D 224914 CDS NP_541760.1 17989127 1198554 complement(820750..821502) 1 NC_003318.1 lysozyme M1 precursor 821502 1198554 BMEII0782 Brucella melitensis bv. 1 str. 16M lysozyme M1 precursor NP_541760.1 820750 R 224914 CDS NP_541761.1 17989128 1198555 821676..823109 1 NC_003318.1 Na(+)-linked D-alanine glycine permease 823109 1198555 BMEII0783 Brucella melitensis bv. 1 str. 16M Na(+)-linked D-alanine glycine permease NP_541761.1 821676 D 224914 CDS NP_541762.1 17989129 1198556 complement(823361..824140) 1 NC_003318.1 hydroxlase 824140 1198556 BMEII0784 Brucella melitensis bv. 1 str. 16M hydroxlase NP_541762.1 823361 R 224914 CDS NP_541763.1 17989130 1198557 824462..824911 1 NC_003318.1 MarR family transcriptional regulator 824911 1198557 BMEII0785 Brucella melitensis bv. 1 str. 16M MarR family transcriptional regulator NP_541763.1 824462 D 224914 CDS NP_541764.1 17989131 1198558 824943..826268 1 NC_003318.1 NADH dehydrogenase 826268 1198558 BMEII0786 Brucella melitensis bv. 1 str. 16M NADH dehydrogenase NP_541764.1 824943 D 224914 CDS NP_541765.1 17989132 1198559 complement(826391..826741) 1 NC_003318.1 uroporphyrin-III C-methyltransferase 826741 1198559 BMEII0787 Brucella melitensis bv. 1 str. 16M uroporphyrin-III C-methyltransferase NP_541765.1 826391 R 224914 CDS NP_541766.1 17989133 1198560 complement(826936..827169) 1 NC_003318.1 hypothetical protein 827169 1198560 BMEII0788 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541766.1 826936 R 224914 CDS NP_541767.1 17989134 1198561 complement(827166..827480) 1 NC_003318.1 hypothetical protein 827480 1198561 BMEII0789 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541767.1 827166 R 224914 CDS NP_541768.1 17989135 1198562 827461..827661 1 NC_003318.1 hypothetical protein 827661 1198562 BMEII0790 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541768.1 827461 D 224914 CDS NP_541769.1 17989136 1198563 827855..828571 1 NC_003318.1 two component response regulator 828571 1198563 BMEII0791 Brucella melitensis bv. 1 str. 16M two component response regulator NP_541769.1 827855 D 224914 CDS NP_541770.1 17989137 1198564 828568..829992 1 NC_003318.1 sensory transduction histidine kinase 829992 1198564 BMEII0792 Brucella melitensis bv. 1 str. 16M sensory transduction histidine kinase NP_541770.1 828568 D 224914 CDS NP_541771.1 17989138 1198565 complement(830064..831041) 1 NC_003318.1 multidrug resistance efflux pump 831041 1198565 BMEII0793 Brucella melitensis bv. 1 str. 16M multidrug resistance efflux pump NP_541771.1 830064 R 224914 CDS NP_541772.1 17989139 1198566 complement(831138..832130) 1 NC_003318.1 multidrug resistance protein B 832130 1198566 BMEII0794 Brucella melitensis bv. 1 str. 16M multidrug resistance protein B NP_541772.1 831138 R 224914 CDS NP_541773.1 17989140 1198567 complement(831952..832686) 1 NC_003318.1 multidrug resistance protein B 832686 1198567 BMEII0795 Brucella melitensis bv. 1 str. 16M multidrug resistance protein B NP_541773.1 831952 R 224914 CDS NP_541774.1 17989141 1198568 complement(832760..833128) 1 NC_003318.1 MarR family transcriptional regulator 833128 1198568 BMEII0796 Brucella melitensis bv. 1 str. 16M MarR family transcriptional regulator NP_541774.1 832760 R 224914 CDS NP_541775.1 17989142 1198569 833526..834617 1 NC_003318.1 ABC transporter substrate-binding protein 834617 1198569 BMEII0797 Brucella melitensis bv. 1 str. 16M ABC transporter substrate-binding protein NP_541775.1 833526 D 224914 CDS NP_541776.1 17989143 1198570 834630..835430 1 NC_003318.1 nitrate transport ATP-binding protein NrtC 835430 1198570 BMEII0798 Brucella melitensis bv. 1 str. 16M nitrate transport ATP-binding protein NrtC NP_541776.1 834630 D 224914 CDS NP_541777.1 17989144 1198571 835387..836241 1 NC_003318.1 nitrate transport permease NRTB 836241 1198571 BMEII0799 Brucella melitensis bv. 1 str. 16M nitrate transport permease NRTB NP_541777.1 835387 D 224914 CDS NP_541778.1 17989145 1198572 complement(836248..836727) 1 NC_003318.1 transcriptional regulator 836727 1198572 BMEII0800 Brucella melitensis bv. 1 str. 16M transcriptional regulator NP_541778.1 836248 R 224914 CDS NP_541779.1 17989146 1198573 complement(836684..837823) 1 NC_003318.1 daunorubicin resistance transmembrane protein 837823 1198573 BMEII0801 Brucella melitensis bv. 1 str. 16M daunorubicin resistance transmembrane protein NP_541779.1 836684 R 224914 CDS NP_541780.1 17989147 1198574 complement(837820..838839) 1 NC_003318.1 daunorubicin resistance ATP-binding protein DRRA 838839 1198574 BMEII0802 Brucella melitensis bv. 1 str. 16M daunorubicin resistance ATP-binding protein DRRA NP_541780.1 837820 R 224914 CDS NP_541781.1 17989148 1198575 complement(838751..839695) 1 NC_003318.1 multidrug resistance protein A 839695 1198575 BMEII0803 Brucella melitensis bv. 1 str. 16M multidrug resistance protein A NP_541781.1 838751 R 224914 CDS NP_541782.1 17989149 1198576 complement(839700..840419) 1 NC_003318.1 TETR family transcriptional regulator 840419 1198576 BMEII0804 Brucella melitensis bv. 1 str. 16M TETR family transcriptional regulator NP_541782.1 839700 R 224914 CDS NP_541783.1 17989150 1198577 complement(840722..841036) 1 NC_003318.1 hypothetical protein 841036 1198577 BMEII0805 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541783.1 840722 R 224914 CDS NP_541784.1 17989151 1198578 complement(840996..842054) 1 NC_003318.1 transmembrane protein 842054 1198578 BMEII0806 Brucella melitensis bv. 1 str. 16M transmembrane protein NP_541784.1 840996 R 224914 CDS NP_541785.1 17989152 1198579 842300..843007 1 NC_003318.1 GntR family transcriptional regulator 843007 1198579 BMEII0807 Brucella melitensis bv. 1 str. 16M GntR family transcriptional regulator NP_541785.1 842300 D 224914 CDS NP_541786.1 17989153 1198580 complement(843030..843686) 1 NC_003318.1 hypothetical protein 843686 1198580 BMEII0808 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541786.1 843030 R 224914 CDS NP_541787.1 17989154 1198581 complement(843464..843871) 1 NC_003318.1 hypothetical protein 843871 1198581 BMEII0809 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541787.1 843464 R 224914 CDS NP_541788.1 17989155 1198582 complement(843871..844224) 1 NC_003318.1 ArsR family transcriptional regulator 844224 1198582 BMEII0810 Brucella melitensis bv. 1 str. 16M ArsR family transcriptional regulator NP_541788.1 843871 R 224914 CDS NP_541789.1 17989156 1198583 844558..845448 1 NC_003318.1 hypothetical protein 845448 1198583 BMEII0811 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541789.1 844558 D 224914 CDS NP_541790.2 161511169 1198584 846194..846688 1 NC_003318.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 846688 def 1198584 def Brucella melitensis bv. 1 str. 16M peptide deformylase NP_541790.2 846194 D 224914 CDS NP_541791.1 17989158 1198585 complement(846741..847979) 1 NC_003318.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase 847979 1198585 BMEII0813 Brucella melitensis bv. 1 str. 16M D-3-phosphoglycerate dehydrogenase NP_541791.1 846741 R 224914 CDS NP_541792.1 17989159 1198586 complement(848203..849186) 1 NC_003318.1 AraC family transcriptional regulator 849186 1198586 BMEII0814 Brucella melitensis bv. 1 str. 16M AraC family transcriptional regulator NP_541792.1 848203 R 224914 CDS NP_541793.1 17989160 1198587 849274..850980 1 NC_003318.1 acetyl-coenzyme A synthetase 850980 1198587 BMEII0815 Brucella melitensis bv. 1 str. 16M acetyl-coenzyme A synthetase NP_541793.1 849274 D 224914 CDS NP_541794.1 17989161 1198588 850993..851760 1 NC_003318.1 3-oxoacyl-ACP reductase 851760 1198588 BMEII0816 Brucella melitensis bv. 1 str. 16M 3-oxoacyl-ACP reductase NP_541794.1 850993 D 224914 CDS NP_541795.1 17989162 1198589 851829..853019 1 NC_003318.1 acetyl-COA acetyltransferase 853019 1198589 BMEII0817 Brucella melitensis bv. 1 str. 16M acetyl-COA acetyltransferase NP_541795.1 851829 D 224914 CDS NP_541796.1 17989163 1198590 853019..854161 1 NC_003318.1 acyl-CoA dehydrogenase 854161 1198590 BMEII0818 Brucella melitensis bv. 1 str. 16M acyl-CoA dehydrogenase NP_541796.1 853019 D 224914 CDS NP_541797.1 17989164 1198591 complement(854146..854586) 1 NC_003318.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress; methionine sulfoxide reductase B 854586 1198591 BMEII0819 Brucella melitensis bv. 1 str. 16M methionine sulfoxide reductase B NP_541797.1 854146 R 224914 CDS NP_541798.1 17989165 1198592 complement(854671..855570) 1 NC_003318.1 ALS operon regulatory protein 855570 1198592 BMEII0820 Brucella melitensis bv. 1 str. 16M ALS operon regulatory protein NP_541798.1 854671 R 224914 CDS NP_541799.1 17989166 1198593 855663..856376 1 NC_003318.1 multidrug resistance protein 856376 1198593 BMEII0821 Brucella melitensis bv. 1 str. 16M multidrug resistance protein NP_541799.1 855663 D 224914 CDS NP_541800.1 17989167 1198594 856241..856963 1 NC_003318.1 multidrug resistance protein 856963 1198594 BMEII0822 Brucella melitensis bv. 1 str. 16M multidrug resistance protein NP_541800.1 856241 D 224914 CDS NP_541801.1 17989168 1198595 857090..857257 1 NC_003318.1 glycerol kinase 857257 1198595 BMEII0823 Brucella melitensis bv. 1 str. 16M glycerol kinase NP_541801.1 857090 D 224914 CDS NP_541802.1 17989169 1198596 857516..858586 1 NC_003318.1 glycerol kinase 858586 1198596 BMEII0824 Brucella melitensis bv. 1 str. 16M glycerol kinase NP_541802.1 857516 D 224914 CDS NP_541803.1 17989170 1198597 858703..859983 1 NC_003318.1 uracil permease 859983 1198597 BMEII0825 Brucella melitensis bv. 1 str. 16M uracil permease NP_541803.1 858703 D 224914 CDS NP_541804.1 17989171 1198598 complement(860179..860835) 1 NC_003318.1 cytoplasmic protein 860835 1198598 BMEII0826 Brucella melitensis bv. 1 str. 16M cytoplasmic protein NP_541804.1 860179 R 224914 CDS NP_541805.1 17989172 1198599 complement(860832..861719) 1 NC_003318.1 glucose-1-phosphate cytidylyltransferase 861719 1198599 BMEII0827 Brucella melitensis bv. 1 str. 16M glucose-1-phosphate cytidylyltransferase NP_541805.1 860832 R 224914 CDS NP_541806.1 17989173 1198600 complement(861644..862210) 1 NC_003318.1 S-adenosylmethionine-dependent methyltransferase 862210 1198600 BMEII0828 Brucella melitensis bv. 1 str. 16M S-adenosylmethionine-dependent methyltransferase NP_541806.1 861644 R 224914 CDS NP_541807.1 17989174 1198601 complement(862282..862944) 1 NC_003318.1 S-adenosylmethionine-dependent methyltransferase 862944 1198601 BMEII0829 Brucella melitensis bv. 1 str. 16M S-adenosylmethionine-dependent methyltransferase NP_541807.1 862282 R 224914 CDS NP_541808.1 17989175 1198602 863234..863788 1 NC_003318.1 dTDP-4-dehydrorhamnose 3,5-epimerase / dTDP-4-dehydrorhamnose reductase 863788 1198602 BMEII0830 Brucella melitensis bv. 1 str. 16M dTDP-4-dehydrorhamnose 3,5-epimerase / dTDP-4-dehydrorhamnose reductase NP_541808.1 863234 D 224914 CDS NP_541809.1 17989176 1198603 complement(863751..865064) 1 NC_003318.1 hypothetical protein 865064 1198603 BMEII0831 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541809.1 863751 R 224914 CDS NP_541810.1 17989177 1198604 complement(865103..866170) 1 NC_003318.1 UDP-glucose 4-epimerase 866170 1198604 BMEII0832 Brucella melitensis bv. 1 str. 16M UDP-glucose 4-epimerase NP_541810.1 865103 R 224914 CDS NP_541811.1 17989178 1198605 complement(866285..867619) 1 NC_003318.1 hypothetical protein 867619 1198605 BMEII0833 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541811.1 866285 R 224914 CDS NP_541812.1 17989179 1198606 complement(867598..868959) 1 NC_003318.1 catalyzes the formation of 5-aminovulinate from (S)-4-amino-5-oxopentanoate; glutamate-1-semialdehyde 2,1-aminomutase 868959 1198606 BMEII0834 Brucella melitensis bv. 1 str. 16M glutamate-1-semialdehyde 2,1-aminomutase NP_541812.1 867598 R 224914 CDS NP_541813.1 17989180 1198607 complement(868997..869920) 1 NC_003318.1 glycosyl transferase 869920 1198607 BMEII0835 Brucella melitensis bv. 1 str. 16M glycosyl transferase NP_541813.1 868997 R 224914 CDS NP_541814.1 17989181 1198608 870493..871734 1 NC_003318.1 dTDP-4-dehydrorhamnose 3,5-epimerase 871734 1198608 BMEII0836 Brucella melitensis bv. 1 str. 16M dTDP-4-dehydrorhamnose 3,5-epimerase NP_541814.1 870493 D 224914 CDS NP_541815.1 17989182 1198609 complement(871690..872703) 1 NC_003318.1 glycosyl transferase 872703 1198609 BMEII0837 Brucella melitensis bv. 1 str. 16M glycosyl transferase NP_541815.1 871690 R 224914 CDS NP_541816.1 17989183 1198610 complement(872719..874224) 1 NC_003318.1 succinoglycan biosynthesis transport protein EXOT 874224 1198610 BMEII0838 Brucella melitensis bv. 1 str. 16M succinoglycan biosynthesis transport protein EXOT NP_541816.1 872719 R 224914 CDS NP_541817.1 17989184 1198611 874562..875626 1 NC_003318.1 undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase 875626 1198611 BMEII0839 Brucella melitensis bv. 1 str. 16M undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase NP_541817.1 874562 D 224914 CDS NP_541818.1 17989185 1198612 875548..876504 1 NC_003318.1 cell wall biosynthesis glycosyltransferase 876504 1198612 BMEII0840 Brucella melitensis bv. 1 str. 16M cell wall biosynthesis glycosyltransferase NP_541818.1 875548 D 224914 CDS NP_541819.1 17989186 1198613 876576..877118 1 NC_003318.1 hypothetical protein 877118 1198613 BMEII0841 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541819.1 876576 D 224914 CDS NP_541820.1 17989187 1198614 877115..878377 1 NC_003318.1 hypothetical protein 878377 1198614 BMEII0842 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541820.1 877115 D 224914 CDS NP_541821.1 17989188 1198615 878500..879003 1 NC_003318.1 colanic acid biosynthesis acetyltransferase WCAF 879003 1198615 BMEII0843 Brucella melitensis bv. 1 str. 16M colanic acid biosynthesis acetyltransferase WCAF NP_541821.1 878500 D 224914 CDS NP_541822.1 17989189 1198616 879463..880122 1 NC_003318.1 hypothetical protein 880122 1198616 BMEII0844 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541822.1 879463 D 224914 CDS NP_541823.1 17989190 1198617 complement(880193..881317) 1 NC_003318.1 lipopolysaccharide N-acetylglucosaminyltransferase 881317 1198617 BMEII0845 Brucella melitensis bv. 1 str. 16M lipopolysaccharide N-acetylglucosaminyltransferase NP_541823.1 880193 R 224914 CDS NP_541824.1 17989191 1198618 complement(881314..882537) 1 NC_003318.1 glycosyl transferase 882537 1198618 BMEII0846 Brucella melitensis bv. 1 str. 16M glycosyl transferase NP_541824.1 881314 R 224914 CDS NP_541825.1 17989192 1198619 complement(882570..883886) 1 NC_003318.1 glycosyl transferase 883886 1198619 BMEII0847 Brucella melitensis bv. 1 str. 16M glycosyl transferase NP_541825.1 882570 R 224914 CDS NP_541826.1 17989193 1198620 884084..885154 1 NC_003318.1 GDP-mannose 4,6-dehydratase 885154 1198620 BMEII0848 Brucella melitensis bv. 1 str. 16M GDP-mannose 4,6-dehydratase NP_541826.1 884084 D 224914 CDS NP_541827.1 17989194 1198621 885138..885878 1 NC_003318.1 GDP-4-dehydro-D-rhamnose reductase 885878 1198621 BMEII0849 Brucella melitensis bv. 1 str. 16M GDP-4-dehydro-D-rhamnose reductase NP_541827.1 885138 D 224914 CDS NP_541828.1 17989195 1198622 885773..886117 1 NC_003318.1 GDP-fucose synthetase 886117 1198622 BMEII0850 Brucella melitensis bv. 1 str. 16M GDP-fucose synthetase NP_541828.1 885773 D 224914 CDS NP_541829.1 17989196 1198623 complement(886222..887400) 1 NC_003318.1 exopolysaccharide production protein EXOF precursor 887400 1198623 BMEII0851 Brucella melitensis bv. 1 str. 16M exopolysaccharide production protein EXOF precursor NP_541829.1 886222 R 224914 CDS NP_541830.1 17989197 1198624 complement(887479..889668) 1 NC_003318.1 succinoglycan biosynthesis transport protein exoP 889668 1198624 BMEII0852 Brucella melitensis bv. 1 str. 16M succinoglycan biosynthesis transport protein exoP NP_541830.1 887479 R 224914 CDS NP_541831.1 17989198 1198625 complement(889705..890472) 1 NC_003318.1 two component response regulator 890472 1198625 BMEII0853 Brucella melitensis bv. 1 str. 16M two component response regulator NP_541831.1 889705 R 224914 CDS NP_541832.1 17989199 1198626 890946..891593 1 NC_003318.1 CRP family transcriptional regulator 891593 1198626 BMEII0854 Brucella melitensis bv. 1 str. 16M CRP family transcriptional regulator NP_541832.1 890946 D 224914 CDS NP_541833.1 17989200 1198627 complement(891594..891869) 1 NC_003318.1 hypothetical protein 891869 1198627 BMEII0855 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541833.1 891594 R 224914 CDS NP_541834.1 17989201 1198628 complement(891970..893154) 1 NC_003318.1 N-acetylneuraminic acid mutarotase 893154 1198628 BMEII0856 Brucella melitensis bv. 1 str. 16M N-acetylneuraminic acid mutarotase NP_541834.1 891970 R 224914 CDS NP_541835.1 17989202 1198629 complement(893160..894716) 1 NC_003318.1 N-acetylmannosamine-6-phosphate 2-epimerase 894716 1198629 BMEII0857 Brucella melitensis bv. 1 str. 16M N-acetylmannosamine-6-phosphate 2-epimerase NP_541835.1 893160 R 224914 CDS NP_541836.1 17989203 1198630 894897..895625 1 NC_003318.1 GntR family transcriptional regulator 895625 1198630 BMEII0858 Brucella melitensis bv. 1 str. 16M GntR family transcriptional regulator NP_541836.1 894897 D 224914 CDS NP_541837.1 17989204 1198631 895703..897205 1 NC_003318.1 oligopeptide-binding protein appa precursor 897205 1198631 BMEII0859 Brucella melitensis bv. 1 str. 16M oligopeptide-binding protein appa precursor NP_541837.1 895703 D 224914 CDS NP_541838.1 17989205 1198632 897368..898264 1 NC_003318.1 oligopeptide transport system permease APPB 898264 1198632 BMEII0860 Brucella melitensis bv. 1 str. 16M oligopeptide transport system permease APPB NP_541838.1 897368 D 224914 CDS NP_541839.1 17989206 1198633 898230..899138 1 NC_003318.1 oligopeptide transport system permease APPC 899138 1198633 BMEII0861 Brucella melitensis bv. 1 str. 16M oligopeptide transport system permease APPC NP_541839.1 898230 D 224914 CDS NP_541840.1 17989207 1198634 899107..900075 1 NC_003318.1 dihydrodipicolinate synthase 900075 1198634 BMEII0862 Brucella melitensis bv. 1 str. 16M dihydrodipicolinate synthase NP_541840.1 899107 D 224914 CDS NP_541841.1 17989208 1198635 900086..901102 1 NC_003318.1 oligopeptide transport ATP-binding protein APPD 901102 1198635 BMEII0863 Brucella melitensis bv. 1 str. 16M oligopeptide transport ATP-binding protein APPD NP_541841.1 900086 D 224914 CDS NP_541842.1 17989209 1198636 901018..902052 1 NC_003318.1 oligopeptide transport ATP-binding protein APPF 902052 1198636 BMEII0864 Brucella melitensis bv. 1 str. 16M oligopeptide transport ATP-binding protein APPF NP_541842.1 901018 D 224914 CDS NP_541843.1 17989210 1198637 complement(902126..903115) 1 NC_003318.1 1-carboxy-3-chloro-3,4-dihydroxycyclo hexa-1,5-diene dehydrogenase 903115 1198637 BMEII0865 Brucella melitensis bv. 1 str. 16M 1-carboxy-3-chloro-3,4-dihydroxycyclo hexa-1,5-diene dehydrogenase NP_541843.1 902126 R 224914 CDS NP_541844.1 17989211 1198638 complement(903103..904056) 1 NC_003318.1 oxidoreductase 904056 1198638 BMEII0866 Brucella melitensis bv. 1 str. 16M oxidoreductase NP_541844.1 903103 R 224914 CDS NP_541845.1 17989212 1198639 complement(904302..905429) 1 NC_003318.1 alcohol dehydrogenase 905429 1198639 BMEII0867 Brucella melitensis bv. 1 str. 16M alcohol dehydrogenase NP_541845.1 904302 R 224914 CDS NP_541846.1 17989213 1198640 complement(905492..906655) 1 NC_003318.1 leucine-specific binding protein precursor 906655 1198640 BMEII0868 Brucella melitensis bv. 1 str. 16M leucine-specific binding protein precursor NP_541846.1 905492 R 224914 CDS NP_541847.1 17989214 1198641 complement(906747..908198) 1 NC_003318.1 succinate-semialdehyde dehydrogenase (NADP+) 908198 1198641 BMEII0869 Brucella melitensis bv. 1 str. 16M succinate-semialdehyde dehydrogenase (NADP+) NP_541847.1 906747 R 224914 CDS NP_541848.1 17989215 1198642 complement(908202..909947) 1 NC_003318.1 alcohol dehydrogenase 909947 1198642 BMEII0870 Brucella melitensis bv. 1 str. 16M alcohol dehydrogenase NP_541848.1 908202 R 224914 CDS NP_541849.1 17989216 1198643 complement(909841..910692) 1 NC_003318.1 shikimate 5-dehydrogenase 910692 1198643 BMEII0871 Brucella melitensis bv. 1 str. 16M shikimate 5-dehydrogenase NP_541849.1 909841 R 224914 CDS NP_541850.1 17989217 1198644 complement(910664..911461) 1 NC_003318.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 911461 fabG 1198644 fabG Brucella melitensis bv. 1 str. 16M 3-ketoacyl-ACP reductase NP_541850.1 910664 R 224914 CDS NP_541851.1 17989218 1198645 complement(911464..912222) 1 NC_003318.1 high-affinity branched-chain amino acid transport ATP-binding protein LIVF 912222 1198645 BMEII0873 Brucella melitensis bv. 1 str. 16M high-affinity branched-chain amino acid transport ATP-binding protein LIVF NP_541851.1 911464 R 224914 CDS NP_541852.1 17989219 1198646 complement(912155..914905) 1 NC_003318.1 high-affinity branched-chain amino acid transport system permease LIVH / high-affinity branched-chain amino acid transport ATP-binding protein LIVG 914905 1198646 BMEII0874 Brucella melitensis bv. 1 str. 16M high-affinity branched-chain amino acid transport system permease LIVH / high-affinity branched-chain amino acid transport ATP-binding protein LIVG NP_541852.1 912155 R 224914 CDS NP_541853.1 17989220 1198647 complement(914927..916186) 1 NC_003318.1 leucine-specific binding protein precursor 916186 1198647 BMEII0875 Brucella melitensis bv. 1 str. 16M leucine-specific binding protein precursor NP_541853.1 914927 R 224914 CDS NP_541854.1 17989221 1198648 complement(916222..917262) 1 NC_003318.1 quinone oxidoreductase 917262 1198648 BMEII0876 Brucella melitensis bv. 1 str. 16M quinone oxidoreductase NP_541854.1 916222 R 224914 CDS NP_541855.1 17989222 1198649 complement(917222..917443) 1 NC_003318.1 hypothetical protein 917443 1198649 BMEII0877 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541855.1 917222 R 224914 CDS NP_541856.1 17989223 1198650 917465..918178 1 NC_003318.1 GntR family transcriptional regulator 918178 1198650 BMEII0878 Brucella melitensis bv. 1 str. 16M GntR family transcriptional regulator NP_541856.1 917465 D 224914 CDS NP_541857.1 17989224 1198651 complement(918249..919430) 1 NC_003318.1 cytochrome P450 YJIB 919430 1198651 BMEII0879 Brucella melitensis bv. 1 str. 16M cytochrome P450 YJIB NP_541857.1 918249 R 224914 CDS NP_541858.1 17989225 1198652 919856..921061 1 NC_003318.1 Enables the production of acetyl-CoA by phosphorylating acetate in the presence of ATP and a divalent cation; acetate kinase 921061 1198652 BMEII0880 Brucella melitensis bv. 1 str. 16M acetate kinase NP_541858.1 919856 D 224914 CDS NP_541859.1 17989226 1198653 921082..923460 1 NC_003318.1 phosphoketolase 923460 1198653 BMEII0881 Brucella melitensis bv. 1 str. 16M phosphoketolase NP_541859.1 921082 D 224914 CDS NP_541860.1 17989227 1198654 complement(923718..925091) 1 NC_003318.1 nitrogen fixation protein VnfA 925091 1198654 BMEII0882 Brucella melitensis bv. 1 str. 16M nitrogen fixation protein VnfA NP_541860.1 923718 R 224914 CDS NP_541861.1 17989228 1198655 complement(925112..925948) 1 NC_003318.1 high-affinity iron permease 925948 1198655 BMEII0883 Brucella melitensis bv. 1 str. 16M high-affinity iron permease NP_541861.1 925112 R 224914 CDS NP_541862.1 17989229 1198656 complement(925955..926329) 1 NC_003318.1 hypothetical protein 926329 1198656 BMEII0884 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541862.1 925955 R 224914 CDS NP_541863.1 17989230 1198657 complement(926357..926914) 1 NC_003318.1 hypothetical protein 926914 1198657 BMEII0885 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541863.1 926357 R 224914 CDS NP_541864.1 17989231 1198658 complement(927088..927297) 1 NC_003318.1 hypothetical protein 927297 1198658 BMEII0886 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541864.1 927088 R 224914 CDS NP_541865.1 17989232 1198659 complement(927328..928851) 1 NC_003318.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 928851 guaA 1198659 guaA Brucella melitensis bv. 1 str. 16M GMP synthase NP_541865.1 927328 R 224914 CDS NP_541866.1 17989233 1198660 complement(928960..929589) 1 NC_003318.1 Enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 929589 1198660 BMEII0888 Brucella melitensis bv. 1 str. 16M 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase NP_541866.1 928960 R 224914 CDS NP_541867.1 17989234 1198661 complement(929589..930215) 1 NC_003318.1 phenylacetic acid degradation protein PAAI 930215 1198661 BMEII0889 Brucella melitensis bv. 1 str. 16M phenylacetic acid degradation protein PAAI NP_541867.1 929589 R 224914 CDS NP_541868.1 17989235 1198662 complement(930325..931467) 1 NC_003318.1 16S ribosomal RNA m(5)C 967 methyltransferase 931467 1198662 BMEII0890 Brucella melitensis bv. 1 str. 16M 16S ribosomal RNA m(5)C 967 methyltransferase NP_541868.1 930325 R 224914 CDS NP_541869.1 17989236 1198663 complement(931686..932414) 1 NC_003318.1 disulfide bond formation protein B 932414 1198663 BMEII0891 Brucella melitensis bv. 1 str. 16M disulfide bond formation protein B NP_541869.1 931686 R 224914 CDS NP_541870.1 17989237 1198664 complement(932443..932616) 1 NC_003318.1 hypothetical protein 932616 1198664 BMEII0892 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541870.1 932443 R 224914 CDS NP_541871.1 17989238 1198665 complement(932747..934270) 1 NC_003318.1 catalase 934270 1198665 BMEII0893 Brucella melitensis bv. 1 str. 16M catalase NP_541871.1 932747 R 224914 CDS NP_541872.1 17989239 1198666 934416..935369 1 NC_003318.1 hydrogen peroxide-inducible genes activator 935369 1198666 BMEII0894 Brucella melitensis bv. 1 str. 16M hydrogen peroxide-inducible genes activator NP_541872.1 934416 D 224914 CDS NP_541873.1 17989240 1198667 935603..936547 1 NC_003318.1 hypothetical protein 936547 1198667 BMEII0895 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541873.1 935603 D 224914 CDS NP_541874.1 17989241 1198668 complement(936707..938206) 1 NC_003318.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase 938206 1198668 BMEII0896 Brucella melitensis bv. 1 str. 16M inosine 5'-monophosphate dehydrogenase NP_541874.1 936707 R 224914 CDS NP_541875.1 17989242 1198669 938362..939750 1 NC_003318.1 chloride channel protein 939750 1198669 BMEII0897 Brucella melitensis bv. 1 str. 16M chloride channel protein NP_541875.1 938362 D 224914 CDS NP_541876.1 17989243 1198670 939873..940880 1 NC_003318.1 endo-type 6-aminohexanoate oligomer hydrolase 940880 1198670 BMEII0898 Brucella melitensis bv. 1 str. 16M endo-type 6-aminohexanoate oligomer hydrolase NP_541876.1 939873 D 224914 CDS NP_541877.1 17989244 1198671 941000..942433 1 NC_003318.1 phosphomannomutase 942433 1198671 BMEII0899 Brucella melitensis bv. 1 str. 16M phosphomannomutase NP_541877.1 941000 D 224914 CDS NP_541878.1 17989245 1198672 942430..943845 1 NC_003318.1 mannose-6-phosphate isomerase 943845 1198672 BMEII0900 Brucella melitensis bv. 1 str. 16M mannose-6-phosphate isomerase NP_541878.1 942430 D 224914 CDS NP_541879.1 17989246 1198673 complement(943966..944253) 1 NC_003318.1 LysR family transcriptional regulator 944253 1198673 BMEII0901 Brucella melitensis bv. 1 str. 16M LysR family transcriptional regulator NP_541879.1 943966 R 224914 CDS NP_541880.1 17989247 1198674 complement(944334..944741) 1 NC_003318.1 LysR family transcriptional regulator 944741 1198674 BMEII0902 Brucella melitensis bv. 1 str. 16M LysR family transcriptional regulator NP_541880.1 944334 R 224914 CDS NP_541881.1 17989248 1198675 945144..945347 1 NC_003318.1 hypothetical protein 945347 1198675 BMEII0903 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541881.1 945144 D 224914 CDS NP_541882.1 17989249 1198676 945642..947234 1 NC_003318.1 diguanylate phosphodiesterase 947234 1198676 BMEII0904 Brucella melitensis bv. 1 str. 16M diguanylate phosphodiesterase NP_541882.1 945642 D 224914 CDS NP_541883.1 17989250 1198677 complement(947311..947562) 1 NC_003318.1 hypothetical protein 947562 1198677 BMEII0905 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541883.1 947311 R 224914 CDS NP_541884.1 17989251 1198678 complement(948074..948313) 1 NC_003318.1 inactive form; acid-resistance protein 948313 1198678 BMEII0906 Brucella melitensis bv. 1 str. 16M acid-resistance protein NP_541884.1 948074 R 224914 CDS NP_541885.1 17989252 1198679 complement(948566..948961) 1 NC_003318.1 glutaminase 948961 1198679 BMEII0907 Brucella melitensis bv. 1 str. 16M glutaminase NP_541885.1 948566 R 224914 CDS NP_541886.1 17989253 1198680 complement(948916..949518) 1 NC_003318.1 glutaminase 949518 1198680 BMEII0908 Brucella melitensis bv. 1 str. 16M glutaminase NP_541886.1 948916 R 224914 CDS NP_541887.1 17989254 1198681 complement(949554..951086) 1 NC_003318.1 glutamate/gamma-aminobutyrate antiporter 951086 1198681 BMEII0909 Brucella melitensis bv. 1 str. 16M glutamate/gamma-aminobutyrate antiporter NP_541887.1 949554 R 224914 CDS NP_541888.1 17989255 1198682 complement(951159..952073) 1 NC_003318.1 glutamate decarboxylase beta 952073 1198682 BMEII0910 Brucella melitensis bv. 1 str. 16M glutamate decarboxylase beta NP_541888.1 951159 R 224914 CDS NP_541889.1 17989256 1198683 complement(952074..952577) 1 NC_003318.1 glutamate decarboxylase alpha 952577 1198683 BMEII0911 Brucella melitensis bv. 1 str. 16M glutamate decarboxylase alpha NP_541889.1 952074 R 224914 CDS NP_541890.1 17989257 1198684 complement(952675..952887) 1 NC_003318.1 hypothetical protein 952887 1198684 BMEII0912 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541890.1 952675 R 224914 CDS NP_541891.1 17989258 1198685 953251..953784 1 NC_003318.1 hypothetical protein 953784 1198685 BMEII0913 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541891.1 953251 D 224914 CDS NP_541892.1 17989259 1198686 953838..955193 1 NC_003318.1 acriflavin resistance protein A 955193 1198686 BMEII0914 Brucella melitensis bv. 1 str. 16M acriflavin resistance protein A NP_541892.1 953838 D 224914 CDS NP_541893.1 17989260 1198687 955197..956426 1 NC_003318.1 acriflavin resistance protein F 956426 1198687 BMEII0915 Brucella melitensis bv. 1 str. 16M acriflavin resistance protein F NP_541893.1 955197 D 224914 CDS NP_541894.1 17989261 1198688 956164..958422 1 NC_003318.1 acriflavin resistance protein D 958422 1198688 BMEII0916 Brucella melitensis bv. 1 str. 16M acriflavin resistance protein D NP_541894.1 956164 D 224914 CDS NP_541895.1 17989262 1198689 958419..958919 1 NC_003318.1 hypothetical protein 958919 1198689 BMEII0917 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541895.1 958419 D 224914 CDS NP_541896.1 17989263 1198690 complement(959061..959621) 1 NC_003318.1 hypothetical protein 959621 1198690 BMEII0918 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541896.1 959061 R 224914 CDS NP_541897.1 17989264 1198691 complement(959825..960049) 1 NC_003318.1 hypothetical protein 960049 1198691 BMEII0919 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541897.1 959825 R 224914 CDS NP_541898.1 17989265 1198692 complement(960537..961313) 1 NC_003318.1 spermidine/putrescine ABC transporter permease 961313 1198692 BMEII0920 Brucella melitensis bv. 1 str. 16M spermidine/putrescine ABC transporter permease NP_541898.1 960537 R 224914 CDS NP_541899.1 17989266 1198693 complement(961332..962492) 1 NC_003318.1 spermidine/putrescine ABC transporter permease 962492 1198693 BMEII0921 Brucella melitensis bv. 1 str. 16M spermidine/putrescine ABC transporter permease NP_541899.1 961332 R 224914 CDS NP_541900.1 17989267 1198694 complement(962489..963556) 1 NC_003318.1 spermidine/putrescine ABC transporter ATP-binding protein 963556 1198694 BMEII0922 Brucella melitensis bv. 1 str. 16M spermidine/putrescine ABC transporter ATP-binding protein NP_541900.1 962489 R 224914 CDS NP_541901.1 17989268 1198695 complement(963630..964676) 1 NC_003318.1 spermidine/putrescine-binding periplasmic protein 964676 1198695 BMEII0923 Brucella melitensis bv. 1 str. 16M spermidine/putrescine-binding periplasmic protein NP_541901.1 963630 R 224914 CDS NP_541902.1 17989269 1198696 965157..965444 1 NC_003318.1 hypothetical protein 965444 1198696 BMEII0924 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541902.1 965157 D 224914 CDS NP_541903.1 17989270 1198697 complement(965984..966256) 1 NC_003318.1 works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell; cell division topological specificity factor MinE 966256 minE 1198697 minE Brucella melitensis bv. 1 str. 16M cell division topological specificity factor MinE NP_541903.1 965984 R 224914 CDS NP_541904.1 17989271 1198698 complement(966253..966990) 1 NC_003318.1 cell division inhibitor MIND 966990 1198698 BMEII0926 Brucella melitensis bv. 1 str. 16M cell division inhibitor MIND NP_541904.1 966253 R 224914 CDS NP_541905.1 17989272 1198699 complement(967096..967857) 1 NC_003318.1 blocks the formation of polar Z-ring septums; septum formation inhibitor 967857 minC 1198699 minC Brucella melitensis bv. 1 str. 16M septum formation inhibitor NP_541905.1 967096 R 224914 CDS NP_541906.1 17989273 1198700 968329..968553 1 NC_003318.1 hypothetical protein 968553 1198700 BMEII0928 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541906.1 968329 D 224914 CDS NP_541907.1 17989274 1198701 complement(968723..969730) 1 NC_003318.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 969730 nrdF 1198701 nrdF Brucella melitensis bv. 1 str. 16M ribonucleotide-diphosphate reductase subunit beta NP_541907.1 968723 R 224914 CDS NP_541908.1 17989275 1198702 complement(969727..971943) 1 NC_003318.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 971943 1198702 BMEII0930 Brucella melitensis bv. 1 str. 16M ribonucleotide-diphosphate reductase subunit alpha NP_541908.1 969727 R 224914 CDS NP_541909.1 17989276 1198703 complement(971919..972326) 1 NC_003318.1 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein 972326 nrdI 1198703 nrdI Brucella melitensis bv. 1 str. 16M ribonucleotide reductase stimulatory protein NP_541909.1 971919 R 224914 CDS NP_541910.1 17989277 1198704 complement(972340..972573) 1 NC_003318.1 glutaredoxin 972573 1198704 BMEII0932 Brucella melitensis bv. 1 str. 16M glutaredoxin NP_541910.1 972340 R 224914 CDS NP_541911.1 17989278 1198705 972831..973160 1 NC_003318.1 hypothetical protein 973160 1198705 BMEII0933 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541911.1 972831 D 224914 CDS NP_541912.1 17989279 1198706 complement(973238..973708) 1 NC_003318.1 nickel resistance protein 973708 1198706 BMEII0934 Brucella melitensis bv. 1 str. 16M nickel resistance protein NP_541912.1 973238 R 224914 CDS NP_541913.1 17989280 1198707 complement(973752..974786) 1 NC_003318.1 nickel resistance protein 974786 1198707 BMEII0935 Brucella melitensis bv. 1 str. 16M nickel resistance protein NP_541913.1 973752 R 224914 CDS NP_541914.1 17989281 1198708 complement(975081..975311) 1 NC_003318.1 hypothetical protein 975311 1198708 BMEII0936 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541914.1 975081 R 224914 CDS NP_541915.1 17989282 1198709 complement(975314..975577) 1 NC_003318.1 hypothetical protein 975577 1198709 BMEII0937 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541915.1 975314 R 224914 CDS NP_541916.1 17989283 1198710 complement(975814..976860) 1 NC_003318.1 myo-inositol 2-dehydrogenase 976860 1198710 BMEII0938 Brucella melitensis bv. 1 str. 16M myo-inositol 2-dehydrogenase NP_541916.1 975814 R 224914 CDS NP_541917.1 17989284 1198711 complement(976869..977678) 1 NC_003318.1 THUA 977678 1198711 BMEII0939 Brucella melitensis bv. 1 str. 16M THUA NP_541917.1 976869 R 224914 CDS NP_541918.1 17989285 1198712 complement(977717..978391) 1 NC_003318.1 maltose/maltodextrin transport ATP-binding protein MALK 978391 1198712 BMEII0940 Brucella melitensis bv. 1 str. 16M maltose/maltodextrin transport ATP-binding protein MALK NP_541918.1 977717 R 224914 CDS NP_541919.1 17989286 1198713 complement(978154..978717) 1 NC_003318.1 maltose/maltodextrin transport ATP-binding protein MALK 978717 1198713 BMEII0941 Brucella melitensis bv. 1 str. 16M maltose/maltodextrin transport ATP-binding protein MALK NP_541919.1 978154 R 224914 CDS NP_541920.1 17989287 1198714 complement(978724..979536) 1 NC_003318.1 maltose transport system permease MALG 979536 1198714 BMEII0942 Brucella melitensis bv. 1 str. 16M maltose transport system permease MALG NP_541920.1 978724 R 224914 CDS NP_541921.1 17989288 1198715 complement(979539..980060) 1 NC_003318.1 maltose transport system permease MALF 980060 1198715 BMEII0943 Brucella melitensis bv. 1 str. 16M maltose transport system permease MALF NP_541921.1 979539 R 224914 CDS NP_541922.1 17989289 1198716 complement(979855..980517) 1 NC_003318.1 maltose transport system permease MALF 980517 1198716 BMEII0944 Brucella melitensis bv. 1 str. 16M maltose transport system permease MALF NP_541922.1 979855 R 224914 CDS NP_541923.1 17989290 1198717 complement(980594..981859) 1 NC_003318.1 maltose-binding periplasmic protein 981859 1198717 BMEII0945 Brucella melitensis bv. 1 str. 16M maltose-binding periplasmic protein NP_541923.1 980594 R 224914 CDS NP_541924.1 17989291 1198718 982210..983226 1 NC_003318.1 LACI-family transcription regulator 983226 1198718 BMEII0946 Brucella melitensis bv. 1 str. 16M LACI-family transcription regulator NP_541924.1 982210 D 224914 CDS NP_541925.1 17989292 1198719 complement(983281..983991) 1 NC_003318.1 upregulated by FixLJ/FixK under oxygen limitation; involved in regulation of genes involved in carbon and amino acid metabolism; transcriptional activator FtrB 983991 ftrB 1198719 ftrB Brucella melitensis bv. 1 str. 16M transcriptional activator FtrB NP_541925.1 983281 R 224914 CDS NP_541926.1 17989293 1198720 984229..987084 1 NC_003318.1 nitrite extrusion protein 987084 1198720 BMEII0948 Brucella melitensis bv. 1 str. 16M nitrite extrusion protein NP_541926.1 984229 D 224914 CDS NP_541927.1 17989294 1198721 986999..988390 1 NC_003318.1 respiratory nitrate reductase 1 alpha chain 988390 1198721 BMEII0949 Brucella melitensis bv. 1 str. 16M respiratory nitrate reductase 1 alpha chain NP_541927.1 986999 D 224914 CDS NP_541928.1 17989295 1198722 987988..990765 1 NC_003318.1 nitrate reductase alpha chain 990765 1198722 BMEII0950 Brucella melitensis bv. 1 str. 16M nitrate reductase alpha chain NP_541928.1 987988 D 224914 CDS NP_541929.1 17989296 1198723 990762..992300 1 NC_003318.1 nitrate reductase beta chain 992300 1198723 BMEII0951 Brucella melitensis bv. 1 str. 16M nitrate reductase beta chain NP_541929.1 990762 D 224914 CDS NP_541930.1 17989297 1198724 992300..993007 1 NC_003318.1 nitrate reductase delta chain 993007 1198724 BMEII0952 Brucella melitensis bv. 1 str. 16M nitrate reductase delta chain NP_541930.1 992300 D 224914 CDS NP_541931.1 17989298 1198725 993018..993743 1 NC_003318.1 respiratory nitrate reductase 2 gamma chain 993743 1198725 BMEII0953 Brucella melitensis bv. 1 str. 16M respiratory nitrate reductase 2 gamma chain NP_541931.1 993018 D 224914 CDS NP_541932.1 17989299 1198726 993869..994684 1 NC_003318.1 peptidyl-prolyl cis-trans isomerase C 994684 1198726 BMEII0954 Brucella melitensis bv. 1 str. 16M peptidyl-prolyl cis-trans isomerase C NP_541932.1 993869 D 224914 CDS NP_541933.1 17989300 1198727 994681..995217 1 NC_003318.1 hypothetical protein 995217 1198727 BMEII0955 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541933.1 994681 D 224914 CDS NP_541934.1 17989301 1198728 complement(995227..995817) 1 NC_003318.1 catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase 995817 1198728 BMEII0956 Brucella melitensis bv. 1 str. 16M 3-octaprenyl-4-hydroxybenzoate carboxy-lyase NP_541934.1 995227 R 224914 CDS NP_541935.1 17989302 1198729 complement(995814..997328) 1 NC_003318.1 3-octaprenyl-4-hydroxybenzoate carboxy-lyase 997328 1198729 BMEII0957 Brucella melitensis bv. 1 str. 16M 3-octaprenyl-4-hydroxybenzoate carboxy-lyase NP_541935.1 995814 R 224914 CDS NP_541936.1 17989303 1198730 997445..997966 1 NC_003318.1 sterol binding protein 997966 1198730 BMEII0958 Brucella melitensis bv. 1 str. 16M sterol binding protein NP_541936.1 997445 D 224914 CDS NP_541937.1 17989304 1198731 997957..998934 1 NC_003318.1 protease 998934 1198731 BMEII0959 Brucella melitensis bv. 1 str. 16M protease NP_541937.1 997957 D 224914 CDS NP_541938.1 17989305 1198732 998937..999869 1 NC_003318.1 protease 999869 1198732 BMEII0960 Brucella melitensis bv. 1 str. 16M protease NP_541938.1 998937 D 224914 CDS NP_541939.1 17989306 1198733 1000297..1001142 1 NC_003318.1 taurine transport ATP-binding protein TAUB 1001142 1198733 BMEII0961 Brucella melitensis bv. 1 str. 16M taurine transport ATP-binding protein TAUB NP_541939.1 1000297 D 224914 CDS NP_541940.1 17989307 1198734 1001139..1001930 1 NC_003318.1 taurine transport permease TAUC 1001930 1198734 BMEII0962 Brucella melitensis bv. 1 str. 16M taurine transport permease TAUC NP_541940.1 1001139 D 224914 CDS NP_541941.1 17989308 1198735 1002035..1002997 1 NC_003318.1 taurine-binding periplasmic protein precursor 1002997 1198735 BMEII0963 Brucella melitensis bv. 1 str. 16M taurine-binding periplasmic protein precursor NP_541941.1 1002035 D 224914 CDS NP_541942.1 17989309 1198736 complement(1003071..1004312) 1 NC_003318.1 asparagine synthetase B (glutamine-hydrolyzing) 1004312 1198736 BMEII0964 Brucella melitensis bv. 1 str. 16M asparagine synthetase B (glutamine-hydrolyzing) NP_541942.1 1003071 R 224914 CDS NP_541943.1 17989310 1198737 complement(1004363..1004803) 1 NC_003318.1 pseudoazurin 1004803 1198737 BMEII0965 Brucella melitensis bv. 1 str. 16M pseudoazurin NP_541943.1 1004363 R 224914 CDS NP_541944.1 17989311 1198738 complement(1004950..1005390) 1 NC_003318.1 CRP family transcriptional regulator 1005390 1198738 BMEII0966 Brucella melitensis bv. 1 str. 16M CRP family transcriptional regulator NP_541944.1 1004950 R 224914 CDS NP_541945.1 17989312 1198739 complement(1005762..1006733) 1 NC_003318.1 NOSX 1006733 1198739 BMEII0967 Brucella melitensis bv. 1 str. 16M NOSX NP_541945.1 1005762 R 224914 CDS NP_541946.1 17989313 1198740 complement(1006540..1006752) 1 NC_003318.1 NOSX 1006752 1198740 BMEII0968 Brucella melitensis bv. 1 str. 16M NOSX NP_541946.1 1006540 R 224914 CDS NP_541947.1 17989314 1198741 complement(1006764..1007303) 1 NC_003318.1 outer-membrane lipoprotein nosL 1007303 1198741 BMEII0969 Brucella melitensis bv. 1 str. 16M outer-membrane lipoprotein nosL NP_541947.1 1006764 R 224914 CDS NP_541948.1 17989315 1198742 complement(1007300..1008121) 1 NC_003318.1 membrane protein NOSY precursor 1008121 1198742 BMEII0970 Brucella melitensis bv. 1 str. 16M membrane protein NOSY precursor NP_541948.1 1007300 R 224914 CDS NP_541949.1 17989316 1198743 complement(1008118..1009113) 1 NC_003318.1 copper transport ATP-binding protein NOSF 1009113 1198743 BMEII0971 Brucella melitensis bv. 1 str. 16M copper transport ATP-binding protein NOSF NP_541949.1 1008118 R 224914 CDS NP_541950.1 17989317 1198744 complement(1009106..1010500) 1 NC_003318.1 copper-binding periplasmic protein precursor 1010500 1198744 BMEII0972 Brucella melitensis bv. 1 str. 16M copper-binding periplasmic protein precursor NP_541950.1 1009106 R 224914 CDS NP_541951.1 17989318 1198745 complement(1010506..1011609) 1 NC_003318.1 reduces nitrous oxide to nitrogen; nitrous-oxide reductase precurser 1011609 1198745 BMEII0973 Brucella melitensis bv. 1 str. 16M nitrous-oxide reductase precurser NP_541951.1 1010506 R 224914 CDS NP_541952.1 17989319 1198746 complement(1011667..1012425) 1 NC_003318.1 nitrous-oxide reductase 1012425 1198746 BMEII0974 Brucella melitensis bv. 1 str. 16M nitrous-oxide reductase NP_541952.1 1011667 R 224914 CDS NP_541953.1 17989320 1198747 complement(1012446..1014671) 1 NC_003318.1 regulatory protein NOSR 1014671 1198747 BMEII0975 Brucella melitensis bv. 1 str. 16M regulatory protein NOSR NP_541953.1 1012446 R 224914 CDS NP_541954.1 17989321 1198748 1015303..1017210 1 NC_003318.1 ABC transporter ATP-binding protein 1017210 1198748 BMEII0976 Brucella melitensis bv. 1 str. 16M ABC transporter ATP-binding protein NP_541954.1 1015303 D 224914 CDS NP_541955.1 17989322 1198749 1017358..1017834 1 NC_003318.1 hypothetical protein 1017834 1198749 BMEII0977 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541955.1 1017358 D 224914 CDS NP_541956.1 17989323 1198750 1017831..1018496 1 NC_003318.1 hypothetical protein 1018496 1198750 BMEII0978 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541956.1 1017831 D 224914 CDS NP_541957.1 17989324 1198751 complement(1018633..1020249) 1 NC_003318.1 D-ribulokinase 1020249 1198751 BMEII0979 Brucella melitensis bv. 1 str. 16M D-ribulokinase NP_541957.1 1018633 R 224914 CDS NP_541958.1 17989325 1198752 complement(1020250..1020978) 1 NC_003318.1 ribitol 2-dehydrogenase 1020978 1198752 BMEII0980 Brucella melitensis bv. 1 str. 16M ribitol 2-dehydrogenase NP_541958.1 1020250 R 224914 CDS NP_541959.1 17989326 1198753 complement(1021266..1022462) 1 NC_003318.1 xylose transport system permease XYLH 1022462 1198753 BMEII0981 Brucella melitensis bv. 1 str. 16M xylose transport system permease XYLH NP_541959.1 1021266 R 224914 CDS NP_541960.1 17989327 1198754 complement(1022502..1023368) 1 NC_003318.1 galactoside transport ATP-binding protein mglA 1023368 1198754 BMEII0982 Brucella melitensis bv. 1 str. 16M galactoside transport ATP-binding protein mglA NP_541960.1 1022502 R 224914 CDS NP_541961.1 17989328 1198755 complement(1023673..1024710) 1 NC_003318.1 D-galactose-binding periplasmic protein precursor 1024710 1198755 BMEII0983 Brucella melitensis bv. 1 str. 16M D-galactose-binding periplasmic protein precursor NP_541961.1 1023673 R 224914 CDS NP_541962.1 17989329 1198756 1024724..1024945 1 NC_003318.1 hypothetical protein 1024945 1198756 BMEII0984 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541962.1 1024724 D 224914 CDS NP_541963.1 17989330 1198757 complement(1025126..1026181) 1 NC_003318.1 ribitol operon repressor 1026181 1198757 BMEII0985 Brucella melitensis bv. 1 str. 16M ribitol operon repressor NP_541963.1 1025126 R 224914 CDS NP_541964.1 17989331 1198758 complement(1026264..1026959) 1 NC_003318.1 CRP family transcriptional regulator 1026959 1198758 BMEII0986 Brucella melitensis bv. 1 str. 16M CRP family transcriptional regulator NP_541964.1 1026264 R 224914 CDS NP_541965.1 17989332 1198759 complement(1027060..1027911) 1 NC_003318.1 NirV precursor 1027911 1198759 BMEII0987 Brucella melitensis bv. 1 str. 16M NirV precursor NP_541965.1 1027060 R 224914 CDS NP_541966.1 17989333 1198760 complement(1028114..1029244) 1 NC_003318.1 copper-containing nitrite reductase precursor 1029244 1198760 BMEII0988 Brucella melitensis bv. 1 str. 16M copper-containing nitrite reductase precursor NP_541966.1 1028114 R 224914 CDS NP_541967.1 17989334 1198761 complement(1029600..1030202) 1 NC_003318.1 hypothetical protein 1030202 1198761 BMEII0989 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541967.1 1029600 R 224914 CDS NP_541968.1 17989335 1198762 complement(1030249..1030833) 1 NC_003318.1 farnesyl cysteine carboxyl-methyltransferase 1030833 1198762 BMEII0990 Brucella melitensis bv. 1 str. 16M farnesyl cysteine carboxyl-methyltransferase NP_541968.1 1030249 R 224914 CDS NP_541969.1 17989336 1198763 complement(1030830..1032005) 1 NC_003318.1 hypothetical protein 1032005 1198763 BMEII0991 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541969.1 1030830 R 224914 CDS NP_541970.1 17989337 1198764 complement(1032129..1032455) 1 NC_003318.1 hypothetical protein 1032455 1198764 BMEII0992 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541970.1 1032129 R 224914 CDS NP_541971.1 17989338 1198765 complement(1032462..1032989) 1 NC_003318.1 hypothetical protein 1032989 1198765 BMEII0993 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541971.1 1032462 R 224914 CDS NP_541972.1 17989339 1198766 complement(1032986..1033822) 1 NC_003318.1 hypothetical protein 1033822 1198766 BMEII0994 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541972.1 1032986 R 224914 CDS NP_541973.1 17989340 1198767 complement(1034389..1034703) 1 NC_003318.1 hypothetical protein 1034703 1198767 BMEII0995 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541973.1 1034389 R 224914 CDS NP_541974.1 17989341 1198768 complement(1034860..1036761) 1 NC_003318.1 NorD protein 1036761 1198768 BMEII0996 Brucella melitensis bv. 1 str. 16M NorD protein NP_541974.1 1034860 R 224914 CDS NP_541975.1 17989342 1198769 complement(1036773..1037585) 1 NC_003318.1 NorQ protein 1037585 1198769 BMEII0997 Brucella melitensis bv. 1 str. 16M NorQ protein NP_541975.1 1036773 R 224914 CDS NP_541976.1 17989343 1198770 complement(1037676..1039025) 1 NC_003318.1 nitric-oxide reductase subunit B 1039025 1198770 BMEII0998 Brucella melitensis bv. 1 str. 16M nitric-oxide reductase subunit B NP_541976.1 1037676 R 224914 CDS NP_541977.1 17989344 1198771 complement(1039051..1039503) 1 NC_003318.1 nitric-oxide reductase cytochrome c chain 1039503 1198771 BMEII0999 Brucella melitensis bv. 1 str. 16M nitric-oxide reductase cytochrome c chain NP_541977.1 1039051 R 224914 CDS NP_541978.1 17989345 1198772 complement(1039663..1039941) 1 NC_003318.1 NORF 1039941 1198772 BMEII1000 Brucella melitensis bv. 1 str. 16M NORF NP_541978.1 1039663 R 224914 CDS NP_541979.1 17989346 1198773 complement(1039949..1040518) 1 NC_003318.1 heme-copper oxidase subunit III 1040518 1198773 BMEII1001 Brucella melitensis bv. 1 str. 16M heme-copper oxidase subunit III NP_541979.1 1039949 R 224914 CDS NP_541980.1 17989347 1198774 1040834..1041247 1 NC_003318.1 calcium or iron-binding protein 1041247 1198774 BMEII1002 Brucella melitensis bv. 1 str. 16M calcium or iron-binding protein NP_541980.1 1040834 D 224914 CDS NP_541981.1 17989348 1198775 complement(1041315..1042583) 1 NC_003318.1 O-antigen transporter 1042583 1198775 BMEII1003 Brucella melitensis bv. 1 str. 16M O-antigen transporter NP_541981.1 1041315 R 224914 CDS NP_541982.1 17989349 1198776 complement(1042645..1042842) 1 NC_003318.1 hypothetical protein 1042842 1198776 BMEII1004 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541982.1 1042645 R 224914 CDS NP_541983.1 17989350 1198777 1042820..1043857 1 NC_003318.1 malate dehydrogenase 1043857 1198777 BMEII1005 Brucella melitensis bv. 1 str. 16M malate dehydrogenase NP_541983.1 1042820 D 224914 CDS NP_541984.1 17989351 1198778 complement(1043920..1044882) 1 NC_003318.1 dihydrodipicolinate synthase 1044882 1198778 BMEII1006 Brucella melitensis bv. 1 str. 16M dihydrodipicolinate synthase NP_541984.1 1043920 R 224914 CDS NP_541985.1 17989352 1198779 complement(1044983..1045684) 1 NC_003318.1 GntR family transcriptional regulator 1045684 1198779 BMEII1007 Brucella melitensis bv. 1 str. 16M GntR family transcriptional regulator NP_541985.1 1044983 R 224914 CDS NP_541986.1 17989353 1198780 1045900..1046793 1 NC_003318.1 hypothetical protein 1046793 1198780 BMEII1008 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541986.1 1045900 D 224914 CDS NP_541987.1 17989354 1198781 1047115..1048251 1 NC_003318.1 c-di-GMP phosphodiesterase A 1048251 1198781 BMEII1009 Brucella melitensis bv. 1 str. 16M c-di-GMP phosphodiesterase A NP_541987.1 1047115 D 224914 CDS NP_541988.1 17989355 1198782 complement(1048294..1049271) 1 NC_003318.1 thiamine biosynthesis lipoprotein APBE precursor 1049271 1198782 BMEII1010 Brucella melitensis bv. 1 str. 16M thiamine biosynthesis lipoprotein APBE precursor NP_541988.1 1048294 R 224914 CDS NP_541989.1 17989356 1198783 complement(1049252..1051453) 1 NC_003318.1 sulfite reductase (NADPH) flavoprotein alpha-component 1051453 1198783 BMEII1011 Brucella melitensis bv. 1 str. 16M sulfite reductase (NADPH) flavoprotein alpha-component NP_541989.1 1049252 R 224914 CDS NP_541990.1 17989357 1198784 complement(1051464..1051934) 1 NC_003318.1 hypothetical protein 1051934 1198784 BMEII1012 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_541990.1 1051464 R 224914 CDS NP_541991.1 17989358 1198785 complement(1052102..1052437) 1 NC_003318.1 cytoplasmic protein 1052437 1198785 BMEII1013 Brucella melitensis bv. 1 str. 16M cytoplasmic protein NP_541991.1 1052102 R 224914 CDS NP_541992.1 17989359 1198786 1052638..1053315 1 NC_003318.1 two component response regulator 1053315 1198786 BMEII1014 Brucella melitensis bv. 1 str. 16M two component response regulator NP_541992.1 1052638 D 224914 CDS NP_541993.1 17989360 1198787 1053312..1054655 1 NC_003318.1 two-component system sensor 1054655 1198787 BMEII1015 Brucella melitensis bv. 1 str. 16M two-component system sensor NP_541993.1 1053312 D 224914 CDS NP_541994.1 17989361 1198788 1054886..1055593 1 NC_003318.1 protease I 1055593 1198788 BMEII1016 Brucella melitensis bv. 1 str. 16M protease I NP_541994.1 1054886 D 224914 CDS NP_541995.1 17989362 1198789 complement(1055639..1056103) 1 NC_003318.1 mercuric resistance operon regulatory protein 1056103 1198789 BMEII1017 Brucella melitensis bv. 1 str. 16M mercuric resistance operon regulatory protein NP_541995.1 1055639 R 224914 CDS NP_541996.1 17989363 1198790 1056189..1057463 1 NC_003318.1 NADH oxidase 1057463 1198790 BMEII1018 Brucella melitensis bv. 1 str. 16M NADH oxidase NP_541996.1 1056189 D 224914 CDS NP_541997.1 17989364 1198791 complement(1057447..1058694) 1 NC_003318.1 alpha-methylacyl-CoA racemase 1058694 1198791 BMEII1019 Brucella melitensis bv. 1 str. 16M alpha-methylacyl-CoA racemase NP_541997.1 1057447 R 224914 CDS NP_541998.1 17989365 1198792 complement(1058852..1060549) 1 NC_003318.1 converts 3-hydroxyadipyl-CoA to beta-ketoadipyl-CoA in phenylacetate degradation; 3-hydroxyacyl-CoA dehydrogenase 1060549 1198792 BMEII1020 Brucella melitensis bv. 1 str. 16M 3-hydroxyacyl-CoA dehydrogenase NP_541998.1 1058852 R 224914 CDS NP_541999.1 17989366 1198793 complement(1060434..1061219) 1 NC_003318.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 1061219 1198793 BMEII1021 Brucella melitensis bv. 1 str. 16M enoyl-CoA hydratase NP_541999.1 1060434 R 224914 CDS NP_542000.1 17989367 1198794 1061455..1062309 1 NC_003318.1 transcriptional regulator 1062309 1198794 BMEII1022 Brucella melitensis bv. 1 str. 16M transcriptional regulator NP_542000.1 1061455 D 224914 CDS NP_542001.1 17989368 1198795 1062138..1063508 1 NC_003318.1 acyl-CoA dehydrogenase 1063508 1198795 BMEII1023 Brucella melitensis bv. 1 str. 16M acyl-CoA dehydrogenase NP_542001.1 1062138 D 224914 CDS NP_542002.1 17989369 1198796 1063570..1064808 1 NC_003318.1 cis,cis-muconate transporter 1064808 1198796 BMEII1024 Brucella melitensis bv. 1 str. 16M cis,cis-muconate transporter NP_542002.1 1063570 D 224914 CDS NP_542003.1 17989370 1198797 complement(1064851..1065078) 1 NC_003318.1 hypothetical protein 1065078 1198797 BMEII1025 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_542003.1 1064851 R 224914 CDS NP_542004.1 17989371 1198798 1065072..1066943 1 NC_003318.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 1066943 mutL 1198798 mutL Brucella melitensis bv. 1 str. 16M DNA mismatch repair protein NP_542004.1 1065072 D 224914 CDS NP_542005.1 17989372 1198799 1067041..1067277 1 NC_003318.1 hypothetical protein 1067277 1198799 BMEII1027 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_542005.1 1067041 D 224914 CDS NP_542006.1 17989373 1198800 complement(1067291..1068316) 1 NC_003318.1 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate; tetraacyldisaccharide 4'-kinase 1068316 lpxK 1198800 lpxK Brucella melitensis bv. 1 str. 16M tetraacyldisaccharide 4'-kinase NP_542006.1 1067291 R 224914 CDS NP_542007.1 17989374 1198801 complement(1068319..1069659) 1 NC_003318.1 catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A; 3-deoxy-D-manno-octulosonic-acid transferase 1069659 1198801 BMEII1029 Brucella melitensis bv. 1 str. 16M 3-deoxy-D-manno-octulosonic-acid transferase NP_542007.1 1068319 R 224914 CDS NP_542008.1 17989375 1198802 complement(1069656..1070399) 1 NC_003318.1 lipoprotein 1070399 1198802 BMEII1030 Brucella melitensis bv. 1 str. 16M lipoprotein NP_542008.1 1069656 R 224914 CDS NP_542009.1 17989376 1198803 complement(1070463..1070714) 1 NC_003318.1 cytoplasmic protein 1070714 1198803 BMEII1031 Brucella melitensis bv. 1 str. 16M cytoplasmic protein NP_542009.1 1070463 R 224914 CDS NP_542010.1 17989377 1198804 complement(1070753..1071562) 1 NC_003318.1 myo-inositol-1(or 4)-monophosphatase 1071562 1198804 BMEII1032 Brucella melitensis bv. 1 str. 16M myo-inositol-1(or 4)-monophosphatase NP_542010.1 1070753 R 224914 CDS NP_542011.1 17989378 1198805 complement(1071549..1072841) 1 NC_003318.1 PMBA protein 1072841 1198805 BMEII1033 Brucella melitensis bv. 1 str. 16M PMBA protein NP_542011.1 1071549 R 224914 CDS NP_542012.1 17989379 1198806 1073031..1074938 1 NC_003318.1 glutathione-regulated potassium-efflux system protein 1074938 1198806 BMEII1034 Brucella melitensis bv. 1 str. 16M glutathione-regulated potassium-efflux system protein NP_542012.1 1073031 D 224914 CDS NP_542013.1 17989380 1198807 complement(1074951..1075832) 1 NC_003318.1 serine protease 1075832 1198807 BMEII1035 Brucella melitensis bv. 1 str. 16M serine protease NP_542013.1 1074951 R 224914 CDS NP_542014.1 17989381 1198808 complement(1075843..1077195) 1 NC_003318.1 zinc protease 1077195 1198808 BMEII1036 Brucella melitensis bv. 1 str. 16M zinc protease NP_542014.1 1075843 R 224914 CDS NP_542015.1 17989382 1198809 complement(1077207..1078601) 1 NC_003318.1 zinc protease 1078601 1198809 BMEII1037 Brucella melitensis bv. 1 str. 16M zinc protease NP_542015.1 1077207 R 224914 CDS NP_542016.1 17989383 1198810 complement(1078838..1079503) 1 NC_003318.1 methyltransferase 1079503 1198810 BMEII1038 Brucella melitensis bv. 1 str. 16M methyltransferase NP_542016.1 1078838 R 224914 CDS NP_542017.1 17989384 1198811 complement(1079382..1081079) 1 NC_003318.1 tRNA pseudouridine synthase A 1081079 1198811 BMEII1039 Brucella melitensis bv. 1 str. 16M tRNA pseudouridine synthase A NP_542017.1 1079382 R 224914 CDS NP_542018.1 17989385 1198812 1081127..1081741 1 NC_003318.1 cytosine deaminase 1081741 1198812 BMEII1040 Brucella melitensis bv. 1 str. 16M cytosine deaminase NP_542018.1 1081127 D 224914 CDS NP_542019.1 17989386 1198813 complement(1081795..1082376) 1 NC_003318.1 cytochrome B561 1082376 1198813 BMEII1041 Brucella melitensis bv. 1 str. 16M cytochrome B561 NP_542019.1 1081795 R 224914 CDS NP_542020.1 17989387 1198814 complement(1082700..1083305) 1 NC_003318.1 hypothetical protein 1083305 1198814 BMEII1042 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_542020.1 1082700 R 224914 CDS NP_542021.1 17989388 1198815 complement(1083563..1086481) 1 NC_003318.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 1086481 ileS 1198815 ileS Brucella melitensis bv. 1 str. 16M isoleucyl-tRNA synthetase NP_542021.1 1083563 R 224914 CDS NP_542022.1 17989389 1198816 complement(1086825..1087814) 1 NC_003318.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 1087814 1198816 BMEII1044 Brucella melitensis bv. 1 str. 16M bifunctional riboflavin kinase/FMN adenylyltransferase NP_542022.1 1086825 R 224914 CDS NP_542023.1 17989390 1198817 complement(1087902..1088762) 1 NC_003318.1 HAD superfamily protein involved in N-acetyl-glucosamine catabolism 1088762 1198817 BMEII1045 Brucella melitensis bv. 1 str. 16M HAD superfamily protein involved in N-acetyl-glucosamine catabolism NP_542023.1 1087902 R 224914 CDS NP_542024.1 17989391 1198818 complement(1088852..1089142) 1 NC_003318.1 hypothetical protein 1089142 1198818 BMEII1046 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_542024.1 1088852 R 224914 CDS NP_542025.1 17989392 1198819 1089231..1089527 1 NC_003318.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 1089527 groES 1198819 groES Brucella melitensis bv. 1 str. 16M co-chaperonin GroES NP_542025.1 1089231 D 224914 CDS NP_542026.1 17989393 1198820 1089618..1091258 1 NC_003318.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; molecular chaperone GroEL 1091258 groEL 1198820 groEL Brucella melitensis bv. 1 str. 16M molecular chaperone GroEL NP_542026.1 1089618 D 224914 CDS NP_542027.1 17989394 1198821 1091387..1091608 1 NC_003318.1 hypothetical protein 1091608 1198821 BMEII1049 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_542027.1 1091387 D 224914 CDS NP_542028.1 17989395 1198822 1091938..1092192 1 NC_003318.1 hypothetical protein 1092192 1198822 BMEII1050 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_542028.1 1091938 D 224914 CDS NP_542029.2 161511168 1198823 1092343..1093734 1 NC_003318.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 1093734 fumC 1198823 fumC Brucella melitensis bv. 1 str. 16M fumarate hydratase NP_542029.2 1092343 D 224914 CDS NP_542030.1 17989397 1198824 1093837..1094238 1 NC_003318.1 transporter 1094238 1198824 BMEII1052 Brucella melitensis bv. 1 str. 16M transporter NP_542030.1 1093837 D 224914 CDS NP_542031.1 17989398 1198825 1094524..1095762 1 NC_003318.1 glucose/galactose transporter 1095762 1198825 BMEII1053 Brucella melitensis bv. 1 str. 16M glucose/galactose transporter NP_542031.1 1094524 D 224914 CDS NP_542032.1 17989399 1198826 complement(1095835..1096530) 1 NC_003318.1 short form of enzyme; requires HisZ for function; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms heteromultimer of HisG and HisZ; ATP phosphoribosyltransferase 1096530 hisG 1198826 hisG Brucella melitensis bv. 1 str. 16M ATP phosphoribosyltransferase NP_542032.1 1095835 R 224914 CDS NP_542033.1 17989400 1198827 complement(1096527..1097663) 1 NC_003318.1 May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine; ATP phosphoribosyltransferase 1097663 hisZ 1198827 hisZ Brucella melitensis bv. 1 str. 16M ATP phosphoribosyltransferase NP_542033.1 1096527 R 224914 CDS NP_542034.1 17989401 1198828 complement(1097666..1099174) 1 NC_003318.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 1099174 hisS 1198828 hisS Brucella melitensis bv. 1 str. 16M histidyl-tRNA synthetase NP_542034.1 1097666 R 224914 CDS NP_542035.1 17989402 1198829 complement(1099285..1099902) 1 NC_003318.1 amino acid transporter LysE 1099902 1198829 BMEII1057 Brucella melitensis bv. 1 str. 16M amino acid transporter LysE NP_542035.1 1099285 R 224914 CDS NP_542036.1 17989403 1198830 complement(1100021..1100701) 1 NC_003318.1 DNA-3-methyladenine glycosylase I 1100701 1198830 BMEII1058 Brucella melitensis bv. 1 str. 16M DNA-3-methyladenine glycosylase I NP_542036.1 1100021 R 224914 CDS NP_542037.1 17989404 1198831 1100818..1101651 1 NC_003318.1 hypothetical protein 1101651 1198831 BMEII1059 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_542037.1 1100818 D 224914 CDS NP_542038.1 17989405 1198832 1101870..1102754 1 NC_003318.1 2,5-diketo-D-gluconic acid reductase 1102754 1198832 BMEII1060 Brucella melitensis bv. 1 str. 16M 2,5-diketo-D-gluconic acid reductase NP_542038.1 1101870 D 224914 CDS NP_542039.1 17989406 1198833 complement(1102977..1104266) 1 NC_003318.1 (S)-2-hydroxy-acid oxidase subunit F 1104266 1198833 BMEII1061 Brucella melitensis bv. 1 str. 16M (S)-2-hydroxy-acid oxidase subunit F NP_542039.1 1102977 R 224914 CDS NP_542040.1 17989407 1198834 complement(1104271..1105305) 1 NC_003318.1 (S)-2-hydroxy-acid oxidase subunit E 1105305 1198834 BMEII1062 Brucella melitensis bv. 1 str. 16M (S)-2-hydroxy-acid oxidase subunit E NP_542040.1 1104271 R 224914 CDS NP_542041.1 17989408 1198835 complement(1105322..1105504) 1 NC_003318.1 glycolate oxidase subunit GLCE 1105504 1198835 BMEII1063 Brucella melitensis bv. 1 str. 16M glycolate oxidase subunit GLCE NP_542041.1 1105322 R 224914 CDS NP_542042.1 17989409 1198836 complement(1105520..1107145) 1 NC_003318.1 (S)-2-hydroxy-acid oxidase subunit D 1107145 1198836 BMEII1064 Brucella melitensis bv. 1 str. 16M (S)-2-hydroxy-acid oxidase subunit D NP_542042.1 1105520 R 224914 CDS NP_542043.1 17989410 1198837 1107310..1108287 1 NC_003318.1 LysR family transcriptional regulator 1108287 1198837 BMEII1065 Brucella melitensis bv. 1 str. 16M LysR family transcriptional regulator NP_542043.1 1107310 D 224914 CDS NP_542044.1 17989411 1198838 1108409..1109221 1 NC_003318.1 pyruvate dehydrogenase complex repressor 1109221 1198838 BMEII1066 Brucella melitensis bv. 1 str. 16M pyruvate dehydrogenase complex repressor NP_542044.1 1108409 D 224914 CDS NP_542045.1 17989412 1198839 1109866..1110105 1 NC_003318.1 cytoplasmic protein 1110105 1198839 BMEII1067 Brucella melitensis bv. 1 str. 16M cytoplasmic protein NP_542045.1 1109866 D 224914 CDS NP_542046.1 17989413 1198840 complement(1110329..1110679) 1 NC_003318.1 cytochrome c2 precursor 1110679 1198840 BMEII1068 Brucella melitensis bv. 1 str. 16M cytochrome c2 precursor NP_542046.1 1110329 R 224914 CDS NP_542047.1 17989414 1198841 complement(1110960..1112423) 1 NC_003318.1 adhesin 1112423 1198841 BMEII1069 Brucella melitensis bv. 1 str. 16M adhesin NP_542047.1 1110960 R 224914 CDS NP_542048.1 17989415 1198842 complement(1112513..1112968) 1 NC_003318.1 adhesin 1112968 1198842 BMEII1070 Brucella melitensis bv. 1 str. 16M adhesin NP_542048.1 1112513 R 224914 CDS NP_542049.1 17989416 1198843 complement(1113742..1114083) 1 NC_003318.1 hypothetical protein 1114083 1198843 BMEII1071 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_542049.1 1113742 R 224914 CDS NP_542050.1 17989417 1198844 complement(1114213..1114437) 1 NC_003318.1 hypothetical protein 1114437 1198844 BMEII1072 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_542050.1 1114213 R 224914 CDS NP_542051.1 17989418 1198845 complement(1114936..1115514) 1 NC_003318.1 cytochrome B561 1115514 1198845 BMEII1073 Brucella melitensis bv. 1 str. 16M cytochrome B561 NP_542051.1 1114936 R 224914 CDS NP_542052.1 17989419 1198846 complement(1115964..1116788) 1 NC_003318.1 citrate lyase beta chain 1116788 1198846 BMEII1074 Brucella melitensis bv. 1 str. 16M citrate lyase beta chain NP_542052.1 1115964 R 224914 CDS NP_542053.1 17989420 1198847 complement(1116782..1117612) 1 NC_003318.1 cytoplasmic protein 1117612 1198847 BMEII1075 Brucella melitensis bv. 1 str. 16M cytoplasmic protein NP_542053.1 1116782 R 224914 CDS NP_542054.1 17989421 1198848 complement(1117686..1118903) 1 NC_003318.1 alpha-methylacyl-CoA racemase 1118903 1198848 BMEII1076 Brucella melitensis bv. 1 str. 16M alpha-methylacyl-CoA racemase NP_542054.1 1117686 R 224914 CDS NP_542055.1 17989422 1198849 1119083..1119967 1 NC_003318.1 LysR family transcriptional regulator 1119967 1198849 BMEII1077 Brucella melitensis bv. 1 str. 16M LysR family transcriptional regulator NP_542055.1 1119083 D 224914 CDS NP_542056.1 17989423 1198850 complement(1120163..1120540) 1 NC_003318.1 hypothetical protein 1120540 1198850 BMEII1078 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_542056.1 1120163 R 224914 CDS NP_542057.1 17989424 1198851 complement(1120592..1121086) 1 NC_003318.1 hypothetical protein 1121086 1198851 BMEII1079 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_542057.1 1120592 R 224914 CDS NP_542058.1 17989425 1198852 complement(1121181..1121921) 1 NC_003318.1 FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliP 1121921 fliP 1198852 fliP Brucella melitensis bv. 1 str. 16M flagellar biosynthesis protein FliP NP_542058.1 1121181 R 224914 CDS NP_542059.1 17989426 1198853 complement(1121918..1122292) 1 NC_003318.1 flagellar protein FliL 1122292 1198853 BMEII1081 Brucella melitensis bv. 1 str. 16M flagellar protein FliL NP_542059.1 1121918 R 224914 CDS NP_542060.1 17989427 1198854 complement(1122422..1123150) 1 NC_003318.1 part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod; flagellar basal body L-ring protein 1123150 flgH 1198854 flgH Brucella melitensis bv. 1 str. 16M flagellar basal body L-ring protein NP_542060.1 1122422 R 224914 CDS NP_542061.1 17989428 1198855 complement(1123147..1123701) 1 NC_003318.1 hypothetical protein 1123701 1198855 BMEII1083 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_542061.1 1123147 R 224914 CDS NP_542062.1 17989429 1198856 complement(1123704..1124777) 1 NC_003318.1 part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum; flagellar basal body P-ring biosynthesis protein FlgA 1124777 flgI 1198856 flgI Brucella melitensis bv. 1 str. 16M flagellar basal body P-ring biosynthesis protein FlgA NP_542062.1 1123704 R 224914 CDS NP_542063.1 17989430 1198857 complement(1125073..1125486) 1 NC_003318.1 required for the assembly of the flagellar basal body P-ring; Bradyrhizobium japonicum has two types of flagella, a single thick flagella and a few thin flagella; the protein in this cluster is associated with the thin flagella; flagellar basal body P-ring biosynthesis protein FlgA 1125486 flgA 1198857 flgA Brucella melitensis bv. 1 str. 16M flagellar basal body P-ring biosynthesis protein FlgA NP_542063.1 1125073 R 224914 CDS NP_542064.1 17989431 1198858 complement(1125549..1126337) 1 NC_003318.1 makes up the distal portion of the flagellar basal body rod; Bradyrhizobium has one thick flagellum and several thin flagella; the Bradyrhizobium protein in this cluster is associated with the thick flagella; flagellar basal body rod protein FlgG 1126337 flgG 1198858 flgG Brucella melitensis bv. 1 str. 16M flagellar basal body rod protein FlgG NP_542064.1 1125549 R 224914 CDS NP_542065.1 17989432 1198859 complement(1126423..1126758) 1 NC_003318.1 forms a junction between the M-ring and FlgB during flagella biosynthesis; Bradyrhizobium has one thick flagellum and several thin flagella; the protein in this cluster is associated with the thin flagella; flagellar hook-basal body protein FliE 1126758 fliE 1198859 fliE Brucella melitensis bv. 1 str. 16M flagellar hook-basal body protein FliE NP_542065.1 1126423 R 224914 CDS NP_542066.1 17989433 1198860 complement(1126758..1127180) 1 NC_003318.1 with FlgF and B makes up the proximal portion of the flagellar basal body rod; flagellar basal body rod protein FlgC 1127180 flgC 1198860 flgC Brucella melitensis bv. 1 str. 16M flagellar basal body rod protein FlgC NP_542066.1 1126758 R 224914 CDS NP_542067.1 17989434 1198861 complement(1127183..1127563) 1 NC_003318.1 with FlgF and C makes up the proximal portion of the flagellar basal body rod; Bradyrhizobium have one thick flagellum and several thin flagella; the proteins in this cluster are associated with the thin flagella; flagellar basal-body rod protein FlgB 1127563 flgB 1198861 flgB Brucella melitensis bv. 1 str. 16M flagellar basal-body rod protein FlgB NP_542067.1 1127183 R 224914 CDS NP_542068.1 17989435 1198862 1127927..1128835 1 NC_003318.1 D-beta-hydroxybutyrate dehydrogenase 1128835 1198862 BMEII1090 Brucella melitensis bv. 1 str. 16M D-beta-hydroxybutyrate dehydrogenase NP_542068.1 1127927 D 224914 CDS NP_542069.1 17989436 1198863 1128801..1130111 1 NC_003318.1 pyridoxal phosphate biosynthesis protein 1130111 1198863 BMEII1091 Brucella melitensis bv. 1 str. 16M pyridoxal phosphate biosynthesis protein NP_542069.1 1128801 D 224914 CDS NP_542070.1 17989437 1198864 1130111..1130896 1 NC_003318.1 hydroxypyruvate isomerase 1130896 1198864 BMEII1092 Brucella melitensis bv. 1 str. 16M hydroxypyruvate isomerase NP_542070.1 1130111 D 224914 CDS NP_542071.1 17989438 1198865 1130893..1131684 1 NC_003318.1 glycerol-3-phosphate regulon repressor 1131684 1198865 BMEII1093 Brucella melitensis bv. 1 str. 16M glycerol-3-phosphate regulon repressor NP_542071.1 1130893 D 224914 CDS NP_542072.1 17989439 1198866 1131684..1132649 1 NC_003318.1 4-hydroxybutyrate dehydrogenase 1132649 1198866 BMEII1094 Brucella melitensis bv. 1 str. 16M 4-hydroxybutyrate dehydrogenase NP_542072.1 1131684 D 224914 CDS NP_542073.1 17989440 1198867 1132633..1133307 1 NC_003318.1 aldolase 1133307 1198867 BMEII1095 Brucella melitensis bv. 1 str. 16M aldolase NP_542073.1 1132633 D 224914 CDS NP_542074.1 17989441 1198868 1133279..1134634 1 NC_003318.1 tartrate transporter 1134634 1198868 BMEII1096 Brucella melitensis bv. 1 str. 16M tartrate transporter NP_542074.1 1133279 D 224914 CDS NP_542075.1 17989442 1198869 complement(1134828..1135235) 1 NC_003318.1 transcriptional regulator SyrB 1135235 1198869 BMEII1097 Brucella melitensis bv. 1 str. 16M transcriptional regulator SyrB NP_542075.1 1134828 R 224914 CDS NP_542076.1 17989443 1198870 complement(1135621..1136649) 1 NC_003318.1 AraC family transcriptional regulator 1136649 1198870 BMEII1098 Brucella melitensis bv. 1 str. 16M AraC family transcriptional regulator NP_542076.1 1135621 R 224914 CDS NP_542077.1 17989444 1198871 complement(1136821..1138254) 1 NC_003318.1 melittin resistance protein PQAB 1138254 1198871 BMEII1099 Brucella melitensis bv. 1 str. 16M melittin resistance protein PQAB NP_542077.1 1136821 R 224914 CDS NP_542078.1 17989445 1198872 complement(1138254..1139093) 1 NC_003318.1 cellobiose phosphotransferase system celC 1139093 1198872 BMEII1100 Brucella melitensis bv. 1 str. 16M cellobiose phosphotransferase system celC NP_542078.1 1138254 R 224914 CDS NP_542079.1 17989446 1198873 complement(1138987..1139967) 1 NC_003318.1 bactoprenol glucosyl transferase / bactoprenol apolipoprotein N-acyltransferase 1139967 1198873 BMEII1101 Brucella melitensis bv. 1 str. 16M bactoprenol glucosyl transferase / bactoprenol apolipoprotein N-acyltransferase NP_542079.1 1138987 R 224914 CDS NP_542080.1 17989447 1198874 complement(1139964..1140353) 1 NC_003318.1 hypothetical protein 1140353 1198874 BMEII1102 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_542080.1 1139964 R 224914 CDS NP_542081.1 17989448 1198875 1140996..1141874 1 NC_003318.1 phosphatidylglycerophosphatase B 1141874 1198875 BMEII1103 Brucella melitensis bv. 1 str. 16M phosphatidylglycerophosphatase B NP_542081.1 1140996 D 224914 CDS NP_542082.1 17989449 1198876 complement(1141899..1142243) 1 NC_003318.1 hypothetical protein 1142243 1198876 BMEII1104 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_542082.1 1141899 R 224914 CDS NP_542083.1 17989450 1198877 complement(1142501..1143643) 1 NC_003318.1 flagellum-specific ATP synthase 1143643 1198877 BMEII1105 Brucella melitensis bv. 1 str. 16M flagellum-specific ATP synthase NP_542083.1 1142501 R 224914 CDS NP_542084.1 17989451 1198878 complement(1143615..1143863) 1 NC_003318.1 hypothetical protein 1143863 1198878 BMEII1106 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_542084.1 1143615 R 224914 CDS NP_542085.1 17989452 1198879 complement(1144069..1144590) 1 NC_003318.1 flagellar basal body rod protein FlgF 1144590 1198879 BMEII1107 Brucella melitensis bv. 1 str. 16M flagellar basal body rod protein FlgF NP_542085.1 1144069 R 224914 CDS NP_542086.1 17989453 1198880 complement(1144590..1145378) 1 NC_003318.1 flagellar basal body rod protein FlgF 1145378 1198880 BMEII1108 Brucella melitensis bv. 1 str. 16M flagellar basal body rod protein FlgF NP_542086.1 1144590 R 224914 CDS NP_542087.1 17989454 1198881 1145425..1146396 1 NC_003318.1 With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotA 1146396 1198881 BMEII1109 Brucella melitensis bv. 1 str. 16M flagellar motor protein MotA NP_542087.1 1145425 D 224914 CDS NP_542088.1 17989455 1198882 1146398..1147348 1 NC_003318.1 flagellar motor switch protein FLIM 1147348 1198882 BMEII1110 Brucella melitensis bv. 1 str. 16M flagellar motor switch protein FLIM NP_542088.1 1146398 D 224914 CDS NP_542089.1 17989456 1198883 1147329..1147790 1 NC_003318.1 hypothetical protein 1147790 1198883 BMEII1111 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_542089.1 1147329 D 224914 CDS NP_542090.1 17989457 1198884 1147814..1148134 1 NC_003318.1 flagellar motor switch protein FLIN 1148134 1198884 BMEII1112 Brucella melitensis bv. 1 str. 16M flagellar motor switch protein FLIN NP_542090.1 1147814 D 224914 CDS NP_542091.1 17989458 1198885 1148151..1148849 1 NC_003318.1 flagellar motor switch protein FLIG 1148849 1198885 BMEII1113 Brucella melitensis bv. 1 str. 16M flagellar motor switch protein FLIG NP_542091.1 1148151 D 224914 CDS NP_542092.1 17989459 1198886 1149140..1150210 1 NC_003318.1 membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export; flagellar biosynthesis protein FlhB 1150210 flhB 1198886 flhB Brucella melitensis bv. 1 str. 16M flagellar biosynthesis protein FlhB NP_542092.1 1149140 D 224914 CDS NP_542093.1 17989460 1198887 1150321..1150854 1 NC_003318.1 hypothetical protein 1150854 1198887 BMEII1115 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_542093.1 1150321 D 224914 CDS NP_542094.1 17989461 1198888 complement(1150820..1151527) 1 NC_003318.1 LuxR family transcriptional regulator 1151527 1198888 BMEII1116 Brucella melitensis bv. 1 str. 16M LuxR family transcriptional regulator NP_542094.1 1150820 R 224914 CDS NP_542095.1 17989462 1198889 complement(1151873..1152616) 1 NC_003318.1 TETR family transcriptional regulator 1152616 1198889 BMEII1117 Brucella melitensis bv. 1 str. 16M TETR family transcriptional regulator NP_542095.1 1151873 R 224914 CDS NP_542096.1 17989463 1198890 1152741..1153958 1 NC_003318.1 multidrug resistance protein A 1153958 1198890 BMEII1118 Brucella melitensis bv. 1 str. 16M multidrug resistance protein A NP_542096.1 1152741 D 224914 CDS NP_542097.1 17989464 1198891 1154051..1155628 1 NC_003318.1 multidrug resistance protein B 1155628 1198891 BMEII1119 Brucella melitensis bv. 1 str. 16M multidrug resistance protein B NP_542097.1 1154051 D 224914 CDS NP_542098.1 17989465 1198892 1156037..1157140 1 NC_003318.1 iron(III)-binding periplasmic protein precursor 1157140 1198892 BMEII1120 Brucella melitensis bv. 1 str. 16M iron(III)-binding periplasmic protein precursor NP_542098.1 1156037 D 224914 CDS NP_542099.1 17989466 1198893 1157349..1158242 1 NC_003318.1 iron ABC transporter permease 1158242 1198893 BMEII1121 Brucella melitensis bv. 1 str. 16M iron ABC transporter permease NP_542099.1 1157349 D 224914 CDS NP_542100.1 17989467 1198894 1158239..1159057 1 NC_003318.1 iron ABC transporter permease 1159057 1198894 BMEII1122 Brucella melitensis bv. 1 str. 16M iron ABC transporter permease NP_542100.1 1158239 D 224914 CDS NP_542101.1 17989468 1198895 1159063..1160124 1 NC_003318.1 iron(III)-transport ATP-binding protein sfuC 1160124 1198895 BMEII1123 Brucella melitensis bv. 1 str. 16M iron(III)-transport ATP-binding protein sfuC NP_542101.1 1159063 D 224914 CDS NP_542102.1 17989469 1198896 complement(1160220..1161629) 1 NC_003318.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 1161629 1198896 BMEII1124 Brucella melitensis bv. 1 str. 16M 6-phosphogluconate dehydrogenase NP_542102.1 1160220 R 224914 CDS NP_542103.1 17989470 1198897 1161946..1162995 1 NC_003318.1 dimeric dihydrodiol dehydrogenase 1162995 1198897 BMEII1125 Brucella melitensis bv. 1 str. 16M dimeric dihydrodiol dehydrogenase NP_542103.1 1161946 D 224914 CDS NP_542104.1 17989471 1198898 complement(1163154..1164128) 1 NC_003318.1 oxidoreductase 1164128 1198898 BMEII1126 Brucella melitensis bv. 1 str. 16M oxidoreductase NP_542104.1 1163154 R 224914 CDS NP_542105.1 17989472 1198899 complement(1164142..1164984) 1 NC_003318.1 exopolysaccharide production protein EXOQ 1164984 1198899 BMEII1127 Brucella melitensis bv. 1 str. 16M exopolysaccharide production protein EXOQ NP_542105.1 1164142 R 224914 CDS NP_542106.1 17989473 1198900 complement(1165436..1166428) 1 NC_003318.1 succinoglycan biosynthesis protein exoM 1166428 1198900 BMEII1128 Brucella melitensis bv. 1 str. 16M succinoglycan biosynthesis protein exoM NP_542106.1 1165436 R 224914 CDS NP_542107.1 17989474 1198901 1166564..1167754 1 NC_003318.1 glycosyl transferase 1167754 1198901 BMEII1129 Brucella melitensis bv. 1 str. 16M glycosyl transferase NP_542107.1 1166564 D 224914 CDS NP_542108.1 17989475 1198902 1167761..1168516 1 NC_003318.1 UDP-N-acetyl-D-mannosaminuronic acid transferase 1168516 1198902 BMEII1130 Brucella melitensis bv. 1 str. 16M UDP-N-acetyl-D-mannosaminuronic acid transferase NP_542108.1 1167761 D 224914 CDS NP_542109.1 17989476 1198903 1168513..1169376 1 NC_003318.1 hypothetical protein 1169376 1198903 BMEII1131 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_542109.1 1168513 D 224914 CDS NP_542110.1 17989477 1198904 1169502..1171220 1 NC_003318.1 succinoglycan biosynthesis transport protein exoP 1171220 1198904 BMEII1132 Brucella melitensis bv. 1 str. 16M succinoglycan biosynthesis transport protein exoP NP_542110.1 1169502 D 224914 CDS NP_542111.1 17989478 1198905 complement(1171296..1172429) 1 NC_003318.1 ornithine decarboxylase 1172429 1198905 BMEII1133 Brucella melitensis bv. 1 str. 16M ornithine decarboxylase NP_542111.1 1171296 R 224914 CDS NP_542112.1 17989479 1198906 1173014..1174219 1 NC_003318.1 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia; amidase 1174219 1198906 BMEII1134 Brucella melitensis bv. 1 str. 16M amidase NP_542112.1 1173014 D 224914 CDS NP_542113.1 17989480 1198907 1174223..1175116 1 NC_003318.1 LysR family transcriptional regulator 1175116 1198907 BMEII1135 Brucella melitensis bv. 1 str. 16M LysR family transcriptional regulator NP_542113.1 1174223 D 224914 CDS NP_542114.1 17989481 1198908 1175168..1175860 1 NC_003318.1 hypothetical protein 1175860 1198908 BMEII1136 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_542114.1 1175168 D 224914 CDS NP_542115.1 17989482 1198909 1175833..1176963 1 NC_003318.1 hypothetical protein 1176963 1198909 BMEII1137 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_542115.1 1175833 D 224914 CDS NP_542116.1 17989483 1198910 1177105..1177473 1 NC_003318.1 hypothetical protein 1177473 1198910 BMEII1138 Brucella melitensis bv. 1 str. 16M hypothetical protein NP_542116.1 1177105 D 224914 CDS