-- dump date 20140619_011346 -- class Genbank::misc_feature -- table misc_feature_note -- id note 444178000001 replication initiation protein RepC; Provisional; Region: PRK13824 444178000002 Replication protein C N-terminal domain; Region: RP-C; pfam03428 444178000003 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 444178000004 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 444178000005 active site 444178000006 tetramer interface [polypeptide binding]; other site 444178000007 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 444178000008 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 444178000009 TM-ABC transporter signature motif; other site 444178000010 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 444178000011 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 444178000012 TM-ABC transporter signature motif; other site 444178000013 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 444178000014 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 444178000015 Walker A/P-loop; other site 444178000016 ATP binding site [chemical binding]; other site 444178000017 Q-loop/lid; other site 444178000018 ABC transporter signature motif; other site 444178000019 Walker B; other site 444178000020 D-loop; other site 444178000021 H-loop/switch region; other site 444178000022 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 444178000023 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 444178000024 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 444178000025 ligand binding site [chemical binding]; other site 444178000026 Predicted secreted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5664 444178000027 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 444178000028 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 444178000029 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 444178000030 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 444178000031 putative NAD(P) binding site [chemical binding]; other site 444178000032 active site 444178000033 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 444178000034 hydrophobic substrate binding pocket; other site 444178000035 Isochorismatase family; Region: Isochorismatase; pfam00857 444178000036 active site 444178000037 conserved cis-peptide bond; other site 444178000038 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 444178000039 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 444178000040 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 444178000041 acyl-activating enzyme (AAE) consensus motif; other site 444178000042 active site 444178000043 AMP binding site [chemical binding]; other site 444178000044 substrate binding site [chemical binding]; other site 444178000045 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 444178000046 isochorismate synthases; Region: isochor_syn; TIGR00543 444178000047 Condensation domain; Region: Condensation; pfam00668 444178000048 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 444178000049 bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108 444178000050 Moco binding site; other site 444178000051 metal coordination site [ion binding]; other site 444178000052 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 444178000053 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 444178000054 pentapeptide MXKDX repeat protein; Region: penta_MxKDx; TIGR02953 444178000055 RNA polymerase sigma factor; Provisional; Region: PRK12539 444178000056 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 444178000057 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 444178000058 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4944 444178000059 Transcriptional regulators [Transcription]; Region: FadR; COG2186 444178000060 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 444178000061 DNA-binding site [nucleotide binding]; DNA binding site 444178000062 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 444178000063 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 444178000064 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 444178000065 putative ligand binding site [chemical binding]; other site 444178000066 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 444178000067 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 444178000068 TM-ABC transporter signature motif; other site 444178000069 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 444178000070 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 444178000071 Walker A/P-loop; other site 444178000072 ATP binding site [chemical binding]; other site 444178000073 Q-loop/lid; other site 444178000074 ABC transporter signature motif; other site 444178000075 Walker B; other site 444178000076 D-loop; other site 444178000077 H-loop/switch region; other site 444178000078 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 444178000079 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 444178000080 Walker A/P-loop; other site 444178000081 ATP binding site [chemical binding]; other site 444178000082 Q-loop/lid; other site 444178000083 ABC transporter signature motif; other site 444178000084 Walker B; other site 444178000085 D-loop; other site 444178000086 H-loop/switch region; other site 444178000087 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 444178000088 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 444178000089 active site 444178000090 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 444178000091 classical (c) SDRs; Region: SDR_c; cd05233 444178000092 NAD(P) binding site [chemical binding]; other site 444178000093 active site 444178000094 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 444178000095 classical (c) SDRs; Region: SDR_c; cd05233 444178000096 NAD(P) binding site [chemical binding]; other site 444178000097 active site 444178000098 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 444178000099 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 444178000100 tetramer interface [polypeptide binding]; other site 444178000101 TPP-binding site [chemical binding]; other site 444178000102 heterodimer interface [polypeptide binding]; other site 444178000103 phosphorylation loop region [posttranslational modification] 444178000104 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 444178000105 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 444178000106 alpha subunit interface [polypeptide binding]; other site 444178000107 TPP binding site [chemical binding]; other site 444178000108 heterodimer interface [polypeptide binding]; other site 444178000109 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 444178000110 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 444178000111 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 444178000112 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 444178000113 shikimate binding site; other site 444178000114 NAD(P) binding site [chemical binding]; other site 444178000115 magnesium-transporting ATPase; Provisional; Region: PRK15122 444178000116 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 444178000117 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 444178000118 Soluble P-type ATPase [General function prediction only]; Region: COG4087 444178000119 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 444178000120 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 444178000121 MgtC family; Region: MgtC; pfam02308 444178000122 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 444178000123 ATP binding site [chemical binding]; other site 444178000124 Mg2+ binding site [ion binding]; other site 444178000125 G-X-G motif; other site 444178000126 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 444178000127 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 444178000128 active site 444178000129 phosphorylation site [posttranslational modification] 444178000130 intermolecular recognition site; other site 444178000131 dimerization interface [polypeptide binding]; other site 444178000132 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 444178000133 dimerization interface [polypeptide binding]; other site 444178000134 DNA binding residues [nucleotide binding] 444178000135 Response regulator receiver domain; Region: Response_reg; pfam00072 444178000136 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 444178000137 active site 444178000138 phosphorylation site [posttranslational modification] 444178000139 intermolecular recognition site; other site 444178000140 dimerization interface [polypeptide binding]; other site 444178000141 N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: HutG; COG3741 444178000142 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 444178000143 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 444178000144 active site 444178000145 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 444178000146 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 444178000147 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 444178000148 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 444178000149 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 444178000150 active site 444178000151 dimer interface [polypeptide binding]; other site 444178000152 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 444178000153 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 444178000154 active site 444178000155 FMN binding site [chemical binding]; other site 444178000156 substrate binding site [chemical binding]; other site 444178000157 3Fe-4S cluster binding site [ion binding]; other site 444178000158 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 444178000159 domain interface; other site 444178000160 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 444178000161 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 444178000162 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 444178000163 active site 444178000164 catalytic triad [active] 444178000165 oxyanion hole [active] 444178000166 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 444178000167 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 444178000168 ligand binding site [chemical binding]; other site 444178000169 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 444178000170 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 444178000171 ATP binding site [chemical binding]; other site 444178000172 Walker A motif; other site 444178000173 hexamer interface [polypeptide binding]; other site 444178000174 Walker B motif; other site 444178000175 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 444178000176 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 444178000177 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 444178000178 VirB7 interaction site; other site 444178000179 Type IV secretory pathway, component VirB8 [Intracellular trafficking and secretion]; Region: VirB8; COG3736 444178000180 Type IV secretory pathway, VirB6 components [Intracellular trafficking and secretion]; Region: VirB6; COG3704 444178000181 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 444178000182 Type IV secretion system proteins; Region: T4SS; pfam07996 444178000183 Type IV secretory pathway, VirB4 components [Intracellular trafficking and secretion]; Region: VirB4; COG3451 444178000184 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 444178000185 Type IV secretory pathway, VirB3 components [Intracellular trafficking and secretion]; Region: VirB3; COG3702 444178000186 TrbC/VIRB2 family; Region: TrbC; pfam04956 444178000187 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 444178000188 N-acetyl-D-glucosamine binding site [chemical binding]; other site 444178000189 catalytic residue [active] 444178000190 lytic murein transglycosylase; Region: MltB_2; TIGR02283 444178000191 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 444178000192 N-acetyl-D-glucosamine binding site [chemical binding]; other site 444178000193 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 444178000194 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 444178000195 active site 444178000196 tetramer interface; other site 444178000197 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5338 444178000198 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 444178000199 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 444178000200 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 444178000201 putative active site [active] 444178000202 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 444178000203 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 444178000204 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 444178000205 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 444178000206 ferrochelatase; Reviewed; Region: hemH; PRK00035 444178000207 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 444178000208 C-terminal domain interface [polypeptide binding]; other site 444178000209 active site 444178000210 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 444178000211 active site 444178000212 N-terminal domain interface [polypeptide binding]; other site 444178000213 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 444178000214 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 444178000215 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 444178000216 hypothetical protein; Provisional; Region: PRK07546 444178000217 substrate-cofactor binding pocket; other site 444178000218 pyridoxal 5'-phosphate binding site [chemical binding]; other site 444178000219 homodimer interface [polypeptide binding]; other site 444178000220 catalytic residue [active] 444178000221 aminodeoxychorismate synthase; Provisional; Region: PRK07508 444178000222 chorismate binding enzyme; Region: Chorismate_bind; cl10555 444178000223 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 444178000224 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 444178000225 active site 444178000226 Zn binding site [ion binding]; other site 444178000227 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 444178000228 Bacterial protein of unknown function (DUF882); Region: Peptidase_M15_2; pfam05951 444178000229 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 444178000230 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 444178000231 active site 444178000232 intersubunit interface [polypeptide binding]; other site 444178000233 catalytic residue [active] 444178000234 Protein of unknown function (DUF3380); Region: DUF3380; pfam11860 444178000235 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 444178000236 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 444178000237 active site residue [active] 444178000238 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 444178000239 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 444178000240 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178000241 dimer interface [polypeptide binding]; other site 444178000242 conserved gate region; other site 444178000243 putative PBP binding loops; other site 444178000244 ABC-ATPase subunit interface; other site 444178000245 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 444178000246 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 444178000247 amidase; Provisional; Region: PRK08310 444178000248 indole-3-acetamide amidohydrolase; Region: PLN02722 444178000249 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 444178000250 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 444178000251 dimer interface [polypeptide binding]; other site 444178000252 active site 444178000253 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 444178000254 catalytic residues [active] 444178000255 substrate binding site [chemical binding]; other site 444178000256 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 444178000257 Chain length determinant protein; Region: Wzz; pfam02706 444178000258 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 444178000259 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 444178000260 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 444178000261 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 444178000262 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 444178000263 active site 444178000264 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 444178000265 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 444178000266 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 444178000267 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 444178000268 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 444178000269 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG0362 444178000270 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 444178000271 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 444178000272 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 444178000273 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 444178000274 Walker A/P-loop; other site 444178000275 ATP binding site [chemical binding]; other site 444178000276 Q-loop/lid; other site 444178000277 ABC transporter signature motif; other site 444178000278 Walker B; other site 444178000279 D-loop; other site 444178000280 H-loop/switch region; other site 444178000281 TOBE domain; Region: TOBE_2; pfam08402 444178000282 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 444178000283 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178000284 dimer interface [polypeptide binding]; other site 444178000285 conserved gate region; other site 444178000286 putative PBP binding loops; other site 444178000287 ABC-ATPase subunit interface; other site 444178000288 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178000289 dimer interface [polypeptide binding]; other site 444178000290 conserved gate region; other site 444178000291 putative PBP binding loops; other site 444178000292 ABC-ATPase subunit interface; other site 444178000293 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 444178000294 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 444178000295 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 444178000296 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 444178000297 putative substrate translocation pore; other site 444178000298 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 444178000299 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 444178000300 HlyD family secretion protein; Region: HlyD_3; pfam13437 444178000301 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 444178000302 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 444178000303 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 444178000304 Autoinducer binding domain; Region: Autoind_bind; pfam03472 444178000305 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 444178000306 DNA binding residues [nucleotide binding] 444178000307 dimerization interface [polypeptide binding]; other site 444178000308 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377 444178000309 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 444178000310 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 444178000311 FliG C-terminal domain; Region: FliG_C; pfam01706 444178000312 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 444178000313 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 444178000314 flagellar motor protein MotA; Validated; Region: PRK09110 444178000315 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 444178000316 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 444178000317 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642 444178000318 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 444178000319 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 444178000320 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002 444178000321 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 444178000322 Walker A motif; other site 444178000323 ATP binding site [chemical binding]; other site 444178000324 Walker B motif; other site 444178000325 PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389 444178000326 active site 444178000327 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 444178000328 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 444178000329 Ligand binding site; other site 444178000330 Putative Catalytic site; other site 444178000331 DXD motif; other site 444178000332 Peptidase family M48; Region: Peptidase_M48; cl12018 444178000333 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807 444178000334 putative active site [active] 444178000335 YdjC motif; other site 444178000336 Mg binding site [ion binding]; other site 444178000337 putative homodimer interface [polypeptide binding]; other site 444178000338 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 444178000339 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 444178000340 Helix-turn-helix domain; Region: HTH_18; pfam12833 444178000341 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 444178000342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 444178000343 D-galactonate transporter; Region: 2A0114; TIGR00893 444178000344 putative substrate translocation pore; other site 444178000345 putative aldolase; Validated; Region: PRK08130 444178000346 intersubunit interface [polypeptide binding]; other site 444178000347 active site 444178000348 Zn2+ binding site [ion binding]; other site 444178000349 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 444178000350 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 444178000351 putative NAD(P) binding site [chemical binding]; other site 444178000352 active site 444178000353 putative substrate binding site [chemical binding]; other site 444178000354 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 444178000355 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 444178000356 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 444178000357 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 444178000358 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 444178000359 Metal-binding active site; metal-binding site 444178000360 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 444178000361 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 444178000362 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 444178000363 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003 444178000364 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782 444178000365 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 444178000366 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790 444178000367 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 444178000368 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 444178000369 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK06005 444178000370 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 444178000371 Uncharacterized conserved protein [Function unknown]; Region: COG3334 444178000372 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 444178000373 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 444178000374 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 444178000375 FliP family; Region: FliP; cl00593 444178000376 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4893 444178000377 Transcriptional regulator [Transcription]; Region: LysR; COG0583 444178000378 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 444178000379 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 444178000380 putative dimerization interface [polypeptide binding]; other site 444178000381 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 444178000382 CoA-transferase family III; Region: CoA_transf_3; pfam02515 444178000383 Uncharacterized conserved protein [Function unknown]; Region: COG3777 444178000384 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 444178000385 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 444178000386 active site 2 [active] 444178000387 active site 1 [active] 444178000388 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 444178000389 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 444178000390 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 444178000391 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 444178000392 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 444178000393 Cytochrome c2 [Energy production and conversion]; Region: COG3474 444178000394 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841 444178000395 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 444178000396 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 444178000397 DNA-binding site [nucleotide binding]; DNA binding site 444178000398 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 444178000399 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 444178000400 transcriptional activator TtdR; Provisional; Region: PRK09801 444178000401 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 444178000402 putative effector binding pocket; other site 444178000403 dimerization interface [polypeptide binding]; other site 444178000404 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 444178000405 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 444178000406 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 444178000407 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 444178000408 FAD binding domain; Region: FAD_binding_4; pfam01565 444178000409 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 444178000410 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 444178000411 active site 444178000412 catalytic tetrad [active] 444178000413 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 444178000414 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 444178000415 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 444178000416 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 444178000417 dimer interface [polypeptide binding]; other site 444178000418 motif 1; other site 444178000419 motif 2; other site 444178000420 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 444178000421 active site 444178000422 motif 3; other site 444178000423 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 444178000424 anticodon binding site; other site 444178000425 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295 444178000426 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 444178000427 motif 1; other site 444178000428 dimer interface [polypeptide binding]; other site 444178000429 active site 444178000430 motif 2; other site 444178000431 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 444178000432 active site 444178000433 motif 3; other site 444178000434 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583 444178000435 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 444178000436 Predicted membrane protein [Function unknown]; Region: COG2259 444178000437 fumarate hydratase; Reviewed; Region: fumC; PRK00485 444178000438 Class II fumarases; Region: Fumarase_classII; cd01362 444178000439 active site 444178000440 tetramer interface [polypeptide binding]; other site 444178000441 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 444178000442 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 444178000443 ring oligomerisation interface [polypeptide binding]; other site 444178000444 ATP/Mg binding site [chemical binding]; other site 444178000445 stacking interactions; other site 444178000446 hinge regions; other site 444178000447 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 444178000448 oligomerisation interface [polypeptide binding]; other site 444178000449 mobile loop; other site 444178000450 roof hairpin; other site 444178000451 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 444178000452 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 444178000453 active site 444178000454 Riboflavin kinase; Region: Flavokinase; smart00904 444178000455 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 444178000456 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 444178000457 active site 444178000458 HIGH motif; other site 444178000459 nucleotide binding site [chemical binding]; other site 444178000460 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 444178000461 active site 444178000462 KMSKS motif; other site 444178000463 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 444178000464 tRNA binding surface [nucleotide binding]; other site 444178000465 anticodon binding site; other site 444178000466 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 444178000467 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 444178000468 nucleoside/Zn binding site; other site 444178000469 dimer interface [polypeptide binding]; other site 444178000470 catalytic motif [active] 444178000471 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 444178000472 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 444178000473 RNA binding surface [nucleotide binding]; other site 444178000474 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 444178000475 active site 444178000476 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 444178000477 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 444178000478 S-adenosylmethionine binding site [chemical binding]; other site 444178000479 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 444178000480 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 444178000481 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 444178000482 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 444178000483 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 444178000484 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 444178000485 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 444178000486 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 444178000487 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 444178000488 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 444178000489 TrkA-N domain; Region: TrkA_N; pfam02254 444178000490 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 444178000491 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 444178000492 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 444178000493 active site 444178000494 Domain of unknown function (DUF4170); Region: DUF4170; pfam13773 444178000495 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 444178000496 putative acyl-acceptor binding pocket; other site 444178000497 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 444178000498 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 444178000499 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 444178000500 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 444178000501 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 444178000502 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3908 444178000503 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 444178000504 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 444178000505 ATP binding site [chemical binding]; other site 444178000506 Mg2+ binding site [ion binding]; other site 444178000507 G-X-G motif; other site 444178000508 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 444178000509 ATP binding site [chemical binding]; other site 444178000510 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 444178000511 benzoate transport; Region: 2A0115; TIGR00895 444178000512 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 444178000513 putative substrate translocation pore; other site 444178000514 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 444178000515 Transcriptional regulator [Transcription]; Region: IclR; COG1414 444178000516 Bacterial transcriptional regulator; Region: IclR; pfam01614 444178000517 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 444178000518 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 444178000519 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 444178000520 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 444178000521 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 444178000522 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 444178000523 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 444178000524 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 444178000525 CoA-transferase family III; Region: CoA_transf_3; pfam02515 444178000526 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 444178000527 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 444178000528 putative active site [active] 444178000529 putative FMN binding site [chemical binding]; other site 444178000530 putative substrate binding site [chemical binding]; other site 444178000531 putative catalytic residue [active] 444178000532 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 444178000533 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 444178000534 DNA binding residues [nucleotide binding] 444178000535 sensor protein QseC; Provisional; Region: PRK10337 444178000536 HAMP domain; Region: HAMP; pfam00672 444178000537 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 444178000538 dimer interface [polypeptide binding]; other site 444178000539 phosphorylation site [posttranslational modification] 444178000540 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 444178000541 Mg2+ binding site [ion binding]; other site 444178000542 G-X-G motif; other site 444178000543 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 444178000544 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 444178000545 active site 444178000546 phosphorylation site [posttranslational modification] 444178000547 intermolecular recognition site; other site 444178000548 dimerization interface [polypeptide binding]; other site 444178000549 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 444178000550 DNA binding site [nucleotide binding] 444178000551 Uncharacterized conserved protein [Function unknown]; Region: COG5591 444178000552 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 444178000553 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 444178000554 ApbE family; Region: ApbE; pfam02424 444178000555 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 444178000556 GAF domain; Region: GAF; pfam01590 444178000557 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 444178000558 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 444178000559 metal binding site [ion binding]; metal-binding site 444178000560 active site 444178000561 I-site; other site 444178000562 Transcriptional regulators [Transcription]; Region: GntR; COG1802 444178000563 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 444178000564 DNA-binding site [nucleotide binding]; DNA binding site 444178000565 FCD domain; Region: FCD; pfam07729 444178000566 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 444178000567 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 444178000568 inhibitor site; inhibition site 444178000569 active site 444178000570 dimer interface [polypeptide binding]; other site 444178000571 catalytic residue [active] 444178000572 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 444178000573 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 444178000574 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 444178000575 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 444178000576 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 444178000577 Cytochrome c; Region: Cytochrom_C; pfam00034 444178000578 MoxR-like ATPases [General function prediction only]; Region: COG0714 444178000579 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 444178000580 Walker A motif; other site 444178000581 ATP binding site [chemical binding]; other site 444178000582 Walker B motif; other site 444178000583 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 444178000584 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 444178000585 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 444178000586 metal ion-dependent adhesion site (MIDAS); other site 444178000587 Uncharacterized conserved protein [Function unknown]; Region: COG4309 444178000588 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 444178000589 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 444178000590 CPxP motif; other site 444178000591 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 444178000592 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 444178000593 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 444178000594 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 444178000595 nucleophilic elbow; other site 444178000596 catalytic triad; other site 444178000597 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 444178000598 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 444178000599 Multicopper oxidase; Region: Cu-oxidase; pfam00394 444178000600 Uncharacterized conserved protein [Function unknown]; Region: COG1262 444178000601 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 444178000602 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 444178000603 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 444178000604 ligand binding site [chemical binding]; other site 444178000605 flexible hinge region; other site 444178000606 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 444178000607 putative switch regulator; other site 444178000608 non-specific DNA interactions [nucleotide binding]; other site 444178000609 DNA binding site [nucleotide binding] 444178000610 sequence specific DNA binding site [nucleotide binding]; other site 444178000611 putative cAMP binding site [chemical binding]; other site 444178000612 Transcriptional regulators [Transcription]; Region: PurR; COG1609 444178000613 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 444178000614 DNA binding site [nucleotide binding] 444178000615 domain linker motif; other site 444178000616 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 444178000617 dimerization interface [polypeptide binding]; other site 444178000618 ligand binding site [chemical binding]; other site 444178000619 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 444178000620 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 444178000621 putative ligand binding site [chemical binding]; other site 444178000622 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 444178000623 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 444178000624 Walker A/P-loop; other site 444178000625 ATP binding site [chemical binding]; other site 444178000626 Q-loop/lid; other site 444178000627 ABC transporter signature motif; other site 444178000628 Walker B; other site 444178000629 D-loop; other site 444178000630 H-loop/switch region; other site 444178000631 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 444178000632 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 444178000633 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 444178000634 TM-ABC transporter signature motif; other site 444178000635 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 444178000636 classical (c) SDRs; Region: SDR_c; cd05233 444178000637 NAD(P) binding site [chemical binding]; other site 444178000638 active site 444178000639 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 444178000640 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 444178000641 N- and C-terminal domain interface [polypeptide binding]; other site 444178000642 active site 444178000643 MgATP binding site [chemical binding]; other site 444178000644 catalytic site [active] 444178000645 metal binding site [ion binding]; metal-binding site 444178000646 carbohydrate binding site [chemical binding]; other site 444178000647 putative homodimer interface [polypeptide binding]; other site 444178000648 RES domain; Region: RES; smart00953 444178000649 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 444178000650 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 444178000651 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 444178000652 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 444178000653 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 444178000654 ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163 444178000655 4Fe-4S binding domain; Region: Fer4_5; pfam12801 444178000656 4Fe-4S binding domain; Region: Fer4_5; pfam12801 444178000657 nitrous-oxide reductase; Validated; Region: PRK02888 444178000658 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 444178000659 Nitrous oxidase accessory protein [Inorganic ion transport and metabolism]; Region: NosD; COG3420 444178000660 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 444178000661 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 444178000662 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 444178000663 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 444178000664 Walker A/P-loop; other site 444178000665 ATP binding site [chemical binding]; other site 444178000666 Q-loop/lid; other site 444178000667 ABC transporter signature motif; other site 444178000668 Walker B; other site 444178000669 D-loop; other site 444178000670 H-loop/switch region; other site 444178000671 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 444178000672 Predicted lipoprotein involved in nitrous oxide reduction [Energy production and conversion]; Region: NosL; COG4314 444178000673 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 444178000674 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 444178000675 ligand binding site [chemical binding]; other site 444178000676 flexible hinge region; other site 444178000677 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 444178000678 putative switch regulator; other site 444178000679 non-specific DNA interactions [nucleotide binding]; other site 444178000680 DNA binding site [nucleotide binding] 444178000681 sequence specific DNA binding site [nucleotide binding]; other site 444178000682 putative cAMP binding site [chemical binding]; other site 444178000683 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 444178000684 pseudoazurin; Region: pseudoazurin; TIGR02375 444178000685 Uncharacterized protein involved in response to NO [Inorganic ion transport and metabolism]; Region: NnrS; COG3213 444178000686 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 444178000687 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178000688 dimer interface [polypeptide binding]; other site 444178000689 conserved gate region; other site 444178000690 putative PBP binding loops; other site 444178000691 ABC-ATPase subunit interface; other site 444178000692 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 444178000693 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 444178000694 Walker A/P-loop; other site 444178000695 ATP binding site [chemical binding]; other site 444178000696 Q-loop/lid; other site 444178000697 ABC transporter signature motif; other site 444178000698 Walker B; other site 444178000699 D-loop; other site 444178000700 H-loop/switch region; other site 444178000701 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 444178000702 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 444178000703 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 444178000704 putative protease; Provisional; Region: PRK15447 444178000705 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 444178000706 Peptidase family U32; Region: Peptidase_U32; pfam01136 444178000707 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 444178000708 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 444178000709 Flavoprotein; Region: Flavoprotein; cl08021 444178000710 Protein of unknown function (DUF2478); Region: DUF2478; pfam10649 444178000711 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 444178000712 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 444178000713 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 444178000714 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 444178000715 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 444178000716 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 444178000717 [4Fe-4S] binding site [ion binding]; other site 444178000718 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 444178000719 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 444178000720 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 444178000721 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 444178000722 molybdopterin cofactor binding site; other site 444178000723 transcriptional activator FtrB; Provisional; Region: ftrB; PRK09392 444178000724 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 444178000725 ligand binding site [chemical binding]; other site 444178000726 flexible hinge region; other site 444178000727 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 444178000728 Transcriptional regulators [Transcription]; Region: PurR; COG1609 444178000729 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 444178000730 DNA binding site [nucleotide binding] 444178000731 domain linker motif; other site 444178000732 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 444178000733 ligand binding site [chemical binding]; other site 444178000734 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 444178000735 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178000736 dimer interface [polypeptide binding]; other site 444178000737 conserved gate region; other site 444178000738 putative PBP binding loops; other site 444178000739 ABC-ATPase subunit interface; other site 444178000740 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 444178000741 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 444178000742 Walker A/P-loop; other site 444178000743 ATP binding site [chemical binding]; other site 444178000744 Q-loop/lid; other site 444178000745 ABC transporter signature motif; other site 444178000746 Walker B; other site 444178000747 D-loop; other site 444178000748 H-loop/switch region; other site 444178000749 TOBE domain; Region: TOBE_2; pfam08402 444178000750 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 444178000751 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 444178000752 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 444178000753 Transmembrane secretion effector; Region: MFS_3; pfam05977 444178000754 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 444178000755 putative substrate translocation pore; other site 444178000756 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 444178000757 catalytic residues [active] 444178000758 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 444178000759 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 444178000760 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 444178000761 Class I ribonucleotide reductase; Region: RNR_I; cd01679 444178000762 active site 444178000763 dimer interface [polypeptide binding]; other site 444178000764 catalytic residues [active] 444178000765 effector binding site; other site 444178000766 R2 peptide binding site; other site 444178000767 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 444178000768 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 444178000769 dimer interface [polypeptide binding]; other site 444178000770 putative radical transfer pathway; other site 444178000771 diiron center [ion binding]; other site 444178000772 tyrosyl radical; other site 444178000773 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 444178000774 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 444178000775 Domain of unknown function (DUF3597); Region: DUF3597; pfam12200 444178000776 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 444178000777 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 444178000778 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 444178000779 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 444178000780 Walker A/P-loop; other site 444178000781 ATP binding site [chemical binding]; other site 444178000782 Q-loop/lid; other site 444178000783 ABC transporter signature motif; other site 444178000784 Walker B; other site 444178000785 D-loop; other site 444178000786 H-loop/switch region; other site 444178000787 TOBE domain; Region: TOBE_2; pfam08402 444178000788 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 444178000789 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178000790 dimer interface [polypeptide binding]; other site 444178000791 conserved gate region; other site 444178000792 putative PBP binding loops; other site 444178000793 ABC-ATPase subunit interface; other site 444178000794 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 444178000795 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 444178000796 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 444178000797 HlyD family secretion protein; Region: HlyD_3; pfam13437 444178000798 Predicted membrane protein [Function unknown]; Region: COG4803 444178000799 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 444178000800 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 444178000801 pyridoxal 5'-phosphate binding site [chemical binding]; other site 444178000802 catalytic residue [active] 444178000803 acid-resistance protein; Provisional; Region: PRK10208 444178000804 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 444178000805 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 444178000806 LysR substrate binding domain; Region: LysR_substrate; pfam03466 444178000807 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 444178000808 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 444178000809 Substrate binding site; other site 444178000810 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 444178000811 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 444178000812 putative active site pocket [active] 444178000813 cleavage site 444178000814 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 444178000815 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 444178000816 putative ion selectivity filter; other site 444178000817 putative pore gating glutamate residue; other site 444178000818 putative H+/Cl- coupling transport residue; other site 444178000819 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 444178000820 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 444178000821 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 444178000822 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 444178000823 active site 444178000824 Cytochrome c [Energy production and conversion]; Region: COG3258 444178000825 Cytochrome c; Region: Cytochrom_C; pfam00034 444178000826 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 444178000827 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 444178000828 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 444178000829 dimerization interface [polypeptide binding]; other site 444178000830 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 444178000831 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 444178000832 tetramer interface [polypeptide binding]; other site 444178000833 heme binding pocket [chemical binding]; other site 444178000834 NADPH binding site [chemical binding]; other site 444178000835 Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495 444178000836 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 444178000837 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 444178000838 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 444178000839 CoenzymeA binding site [chemical binding]; other site 444178000840 subunit interaction site [polypeptide binding]; other site 444178000841 PHB binding site; other site 444178000842 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06026 444178000843 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, putative; Region: MTA/SAH-nuc-hyp; TIGR01705 444178000844 GMP synthase; Reviewed; Region: guaA; PRK00074 444178000845 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 444178000846 AMP/PPi binding site [chemical binding]; other site 444178000847 candidate oxyanion hole; other site 444178000848 catalytic triad [active] 444178000849 potential glutamine specificity residues [chemical binding]; other site 444178000850 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 444178000851 ATP Binding subdomain [chemical binding]; other site 444178000852 Ligand Binding sites [chemical binding]; other site 444178000853 Dimerization subdomain; other site 444178000854 Uncharacterized protein probably involved in high-affinity Fe2+ transport [Inorganic ion transport and metabolism]; Region: Tpd; COG3470 444178000855 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 444178000856 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 444178000857 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 444178000858 4Fe-4S binding domain; Region: Fer4_5; pfam12801 444178000859 putative phosphoketolase; Provisional; Region: PRK05261 444178000860 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 444178000861 TPP-binding site; other site 444178000862 XFP C-terminal domain; Region: XFP_C; pfam09363 444178000863 acetate kinase; Provisional; Region: PRK07058 444178000864 propionate/acetate kinase; Provisional; Region: PRK12379 444178000865 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 444178000866 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 444178000867 TM-ABC transporter signature motif; other site 444178000868 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 444178000869 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 444178000870 TM-ABC transporter signature motif; other site 444178000871 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 444178000872 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 444178000873 Walker A/P-loop; other site 444178000874 ATP binding site [chemical binding]; other site 444178000875 Q-loop/lid; other site 444178000876 ABC transporter signature motif; other site 444178000877 Walker B; other site 444178000878 D-loop; other site 444178000879 H-loop/switch region; other site 444178000880 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 444178000881 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 444178000882 Walker A/P-loop; other site 444178000883 ATP binding site [chemical binding]; other site 444178000884 Q-loop/lid; other site 444178000885 ABC transporter signature motif; other site 444178000886 Walker B; other site 444178000887 D-loop; other site 444178000888 H-loop/switch region; other site 444178000889 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 444178000890 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 444178000891 NAD(P) binding site [chemical binding]; other site 444178000892 active site 444178000893 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 444178000894 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 444178000895 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 444178000896 shikimate binding site; other site 444178000897 NAD(P) binding site [chemical binding]; other site 444178000898 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 444178000899 Zinc-dependent alcohol dehydrogenases (ADH) and class III ADG (AKA formaldehyde dehydrogenase); Region: liver_ADH_like1; cd08281 444178000900 NAD binding site [chemical binding]; other site 444178000901 catalytic Zn binding site [ion binding]; other site 444178000902 substrate binding site [chemical binding]; other site 444178000903 structural Zn binding site [ion binding]; other site 444178000904 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 444178000905 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 444178000906 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 444178000907 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 444178000908 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 444178000909 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 444178000910 Walker A/P-loop; other site 444178000911 ATP binding site [chemical binding]; other site 444178000912 Q-loop/lid; other site 444178000913 ABC transporter signature motif; other site 444178000914 Walker B; other site 444178000915 D-loop; other site 444178000916 H-loop/switch region; other site 444178000917 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 444178000918 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 444178000919 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 444178000920 Walker A/P-loop; other site 444178000921 ATP binding site [chemical binding]; other site 444178000922 Q-loop/lid; other site 444178000923 ABC transporter signature motif; other site 444178000924 Walker B; other site 444178000925 D-loop; other site 444178000926 H-loop/switch region; other site 444178000927 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 444178000928 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 444178000929 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 444178000930 inhibitor site; inhibition site 444178000931 active site 444178000932 dimer interface [polypeptide binding]; other site 444178000933 catalytic residue [active] 444178000934 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 444178000935 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178000936 dimer interface [polypeptide binding]; other site 444178000937 conserved gate region; other site 444178000938 putative PBP binding loops; other site 444178000939 ABC-ATPase subunit interface; other site 444178000940 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 444178000941 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178000942 dimer interface [polypeptide binding]; other site 444178000943 conserved gate region; other site 444178000944 putative PBP binding loops; other site 444178000945 ABC-ATPase subunit interface; other site 444178000946 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 444178000947 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 444178000948 Transcriptional regulators [Transcription]; Region: FadR; COG2186 444178000949 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 444178000950 DNA-binding site [nucleotide binding]; DNA binding site 444178000951 FCD domain; Region: FCD; pfam07729 444178000952 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 444178000953 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 444178000954 putative active site cavity [active] 444178000955 N-acetylmannosamine kinase; Provisional; Region: PRK05082 444178000956 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 444178000957 nucleotide binding site [chemical binding]; other site 444178000958 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 444178000959 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 444178000960 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 444178000961 ligand binding site [chemical binding]; other site 444178000962 flexible hinge region; other site 444178000963 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 444178000964 putative switch regulator; other site 444178000965 non-specific DNA interactions [nucleotide binding]; other site 444178000966 DNA binding site [nucleotide binding] 444178000967 sequence specific DNA binding site [nucleotide binding]; other site 444178000968 putative cAMP binding site [chemical binding]; other site 444178000969 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 444178000970 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 444178000971 DNA binding residues [nucleotide binding] 444178000972 dimerization interface [polypeptide binding]; other site 444178000973 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 444178000974 Chain length determinant protein; Region: Wzz; cl15801 444178000975 AAA domain; Region: AAA_31; pfam13614 444178000976 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 444178000977 G3 box; other site 444178000978 Switch II region; other site 444178000979 G4 box; other site 444178000980 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 444178000981 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 444178000982 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 444178000983 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 444178000984 NADP binding site [chemical binding]; other site 444178000985 active site 444178000986 putative substrate binding site [chemical binding]; other site 444178000987 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 444178000988 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 444178000989 NADP-binding site; other site 444178000990 homotetramer interface [polypeptide binding]; other site 444178000991 substrate binding site [chemical binding]; other site 444178000992 homodimer interface [polypeptide binding]; other site 444178000993 active site 444178000994 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 444178000995 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 444178000996 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 444178000997 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 444178000998 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 444178000999 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 444178001000 putative ADP-binding pocket [chemical binding]; other site 444178001001 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 444178001002 Uncharacterized conserved protein [Function unknown]; Region: COG1434 444178001003 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 444178001004 putative active site [active] 444178001005 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 444178001006 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 444178001007 putative metal binding site; other site 444178001008 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 444178001009 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 444178001010 active site 444178001011 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 444178001012 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 444178001013 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 444178001014 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 444178001015 glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209 444178001016 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 444178001017 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 444178001018 catalytic residue [active] 444178001019 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 444178001020 extended (e) SDRs; Region: SDR_e; cd08946 444178001021 NAD(P) binding site [chemical binding]; other site 444178001022 active site 444178001023 substrate binding site [chemical binding]; other site 444178001024 Uncharacterized protein conserved in bacteria with an aminopeptidase-like domain [General function prediction only]; Region: COG4310 444178001025 M28 Zn-Peptidases; Region: M28_like_3; cd05644 444178001026 active site 444178001027 metal binding site [ion binding]; metal-binding site 444178001028 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 444178001029 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 444178001030 Methyltransferase domain; Region: Methyltransf_23; pfam13489 444178001031 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 444178001032 S-adenosylmethionine binding site [chemical binding]; other site 444178001033 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 444178001034 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 444178001035 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 444178001036 active site 444178001037 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 444178001038 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 444178001039 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 444178001040 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 444178001041 N- and C-terminal domain interface [polypeptide binding]; other site 444178001042 active site 444178001043 MgATP binding site [chemical binding]; other site 444178001044 catalytic site [active] 444178001045 metal binding site [ion binding]; metal-binding site 444178001046 glycerol binding site [chemical binding]; other site 444178001047 homotetramer interface [polypeptide binding]; other site 444178001048 homodimer interface [polypeptide binding]; other site 444178001049 FBP binding site [chemical binding]; other site 444178001050 protein IIAGlc interface [polypeptide binding]; other site 444178001051 methionine sulfoxide reductase B; Provisional; Region: PRK00222 444178001052 SelR domain; Region: SelR; pfam01641 444178001053 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 444178001054 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 444178001055 active site 444178001056 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 444178001057 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 444178001058 dimer interface [polypeptide binding]; other site 444178001059 active site 444178001060 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 444178001061 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 444178001062 NAD binding site [chemical binding]; other site 444178001063 homodimer interface [polypeptide binding]; other site 444178001064 homotetramer interface [polypeptide binding]; other site 444178001065 active site 444178001066 Protein of unknown function (DUF808); Region: DUF808; cl01002 444178001067 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 444178001068 dimerization interface [polypeptide binding]; other site 444178001069 putative DNA binding site [nucleotide binding]; other site 444178001070 putative Zn2+ binding site [ion binding]; other site 444178001071 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 444178001072 Predicted transporter component [General function prediction only]; Region: COG2391 444178001073 Predicted transporter component [General function prediction only]; Region: COG2391 444178001074 Sulphur transport; Region: Sulf_transp; pfam04143 444178001075 Transcriptional regulators [Transcription]; Region: GntR; COG1802 444178001076 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 444178001077 DNA-binding site [nucleotide binding]; DNA binding site 444178001078 FCD domain; Region: FCD; pfam07729 444178001079 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 444178001080 Domain of unknown function DUF20; Region: UPF0118; pfam01594 444178001081 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 444178001082 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 444178001083 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 444178001084 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 444178001085 Peptidase family M23; Region: Peptidase_M23; pfam01551 444178001086 HlyD family secretion protein; Region: HlyD_3; pfam13437 444178001087 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 444178001088 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 444178001089 Walker A/P-loop; other site 444178001090 ATP binding site [chemical binding]; other site 444178001091 Q-loop/lid; other site 444178001092 ABC transporter signature motif; other site 444178001093 Walker B; other site 444178001094 D-loop; other site 444178001095 H-loop/switch region; other site 444178001096 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 444178001097 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 444178001098 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 444178001099 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 444178001100 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 444178001101 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178001102 dimer interface [polypeptide binding]; other site 444178001103 conserved gate region; other site 444178001104 putative PBP binding loops; other site 444178001105 ABC-ATPase subunit interface; other site 444178001106 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 444178001107 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 444178001108 Walker A/P-loop; other site 444178001109 ATP binding site [chemical binding]; other site 444178001110 Q-loop/lid; other site 444178001111 ABC transporter signature motif; other site 444178001112 Walker B; other site 444178001113 D-loop; other site 444178001114 H-loop/switch region; other site 444178001115 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 444178001116 NMT1/THI5 like; Region: NMT1; pfam09084 444178001117 substrate binding pocket [chemical binding]; other site 444178001118 membrane-bound complex binding site; other site 444178001119 hinge residues; other site 444178001120 MarR family; Region: MarR_2; pfam12802 444178001121 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 444178001122 putative substrate translocation pore; other site 444178001123 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 444178001124 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 444178001125 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 444178001126 HlyD family secretion protein; Region: HlyD_3; pfam13437 444178001127 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 444178001128 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 444178001129 active site 444178001130 phosphorylation site [posttranslational modification] 444178001131 intermolecular recognition site; other site 444178001132 dimerization interface [polypeptide binding]; other site 444178001133 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 444178001134 DNA binding site [nucleotide binding] 444178001135 Uncharacterized conserved protein [Function unknown]; Region: COG3189 444178001136 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 444178001137 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 444178001138 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 444178001139 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 444178001140 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 444178001141 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 444178001142 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 444178001143 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 444178001144 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 444178001145 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 444178001146 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 444178001147 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 444178001148 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 444178001149 Homoserine trans-succinylase [Amino acid transport and metabolism]; Region: MetA; COG1897 444178001150 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 444178001151 proposed active site lysine [active] 444178001152 conserved cys residue [active] 444178001153 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 444178001154 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 444178001155 active site 444178001156 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05963 444178001157 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 444178001158 dimer interface [polypeptide binding]; other site 444178001159 active site 444178001160 CoA binding pocket [chemical binding]; other site 444178001161 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 444178001162 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 444178001163 inhibitor-cofactor binding pocket; inhibition site 444178001164 pyridoxal 5'-phosphate binding site [chemical binding]; other site 444178001165 catalytic residue [active] 444178001166 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 444178001167 AAA domain; Region: AAA_26; pfam13500 444178001168 hypothetical protein; Provisional; Region: PRK07505 444178001169 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 444178001170 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 444178001171 catalytic residue [active] 444178001172 biotin synthase; Region: bioB; TIGR00433 444178001173 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 444178001174 FeS/SAM binding site; other site 444178001175 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 444178001176 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 444178001177 MPT binding site; other site 444178001178 trimer interface [polypeptide binding]; other site 444178001179 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 444178001180 dimer interface [polypeptide binding]; other site 444178001181 FMN binding site [chemical binding]; other site 444178001182 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 444178001183 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 444178001184 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 444178001185 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 444178001186 monovalent cation:proton antiporter; Region: 2a6301s02; TIGR00943 444178001187 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 444178001188 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 444178001189 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 444178001190 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12596 444178001191 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 444178001192 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12671 444178001193 Predicted transcriptional regulators [Transcription]; Region: COG1510 444178001194 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 444178001195 dimerization interface [polypeptide binding]; other site 444178001196 putative DNA binding site [nucleotide binding]; other site 444178001197 putative Zn2+ binding site [ion binding]; other site 444178001198 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 444178001199 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 444178001200 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 444178001201 Walker A/P-loop; other site 444178001202 ATP binding site [chemical binding]; other site 444178001203 Q-loop/lid; other site 444178001204 ABC transporter signature motif; other site 444178001205 Walker B; other site 444178001206 D-loop; other site 444178001207 H-loop/switch region; other site 444178001208 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 444178001209 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 444178001210 Walker A/P-loop; other site 444178001211 ATP binding site [chemical binding]; other site 444178001212 Q-loop/lid; other site 444178001213 ABC transporter signature motif; other site 444178001214 Walker B; other site 444178001215 D-loop; other site 444178001216 H-loop/switch region; other site 444178001217 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 444178001218 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 444178001219 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 444178001220 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 444178001221 Predicted outer membrane lipoprotein [Function unknown]; Region: COG4890 444178001222 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 444178001223 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 444178001224 DNA-binding site [nucleotide binding]; DNA binding site 444178001225 UTRA domain; Region: UTRA; pfam07702 444178001226 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 444178001227 nucleotide binding site [chemical binding]; other site 444178001228 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 444178001229 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 444178001230 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 444178001231 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178001232 dimer interface [polypeptide binding]; other site 444178001233 conserved gate region; other site 444178001234 putative PBP binding loops; other site 444178001235 ABC-ATPase subunit interface; other site 444178001236 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 444178001237 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178001238 dimer interface [polypeptide binding]; other site 444178001239 conserved gate region; other site 444178001240 putative PBP binding loops; other site 444178001241 ABC-ATPase subunit interface; other site 444178001242 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 444178001243 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 444178001244 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 444178001245 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 444178001246 Walker A/P-loop; other site 444178001247 ATP binding site [chemical binding]; other site 444178001248 Q-loop/lid; other site 444178001249 ABC transporter signature motif; other site 444178001250 Walker B; other site 444178001251 D-loop; other site 444178001252 H-loop/switch region; other site 444178001253 TOBE domain; Region: TOBE_2; pfam08402 444178001254 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573 444178001255 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 444178001256 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 444178001257 tetramer interface [polypeptide binding]; other site 444178001258 TPP-binding site [chemical binding]; other site 444178001259 heterodimer interface [polypeptide binding]; other site 444178001260 phosphorylation loop region [posttranslational modification] 444178001261 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 444178001262 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 444178001263 alpha subunit interface [polypeptide binding]; other site 444178001264 TPP binding site [chemical binding]; other site 444178001265 heterodimer interface [polypeptide binding]; other site 444178001266 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 444178001267 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 444178001268 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 444178001269 E3 interaction surface; other site 444178001270 lipoyl attachment site [posttranslational modification]; other site 444178001271 e3 binding domain; Region: E3_binding; pfam02817 444178001272 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 444178001273 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 444178001274 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 444178001275 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 444178001276 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 444178001277 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 444178001278 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 444178001279 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 444178001280 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 444178001281 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 444178001282 homodimer interface [polypeptide binding]; other site 444178001283 homotetramer interface [polypeptide binding]; other site 444178001284 active site pocket [active] 444178001285 cleavage site 444178001286 benzoate transport; Region: 2A0115; TIGR00895 444178001287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 444178001288 putative substrate translocation pore; other site 444178001289 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 444178001290 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 444178001291 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 444178001292 Walker A/P-loop; other site 444178001293 ATP binding site [chemical binding]; other site 444178001294 Q-loop/lid; other site 444178001295 ABC transporter signature motif; other site 444178001296 Walker B; other site 444178001297 D-loop; other site 444178001298 H-loop/switch region; other site 444178001299 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 444178001300 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 444178001301 Walker A/P-loop; other site 444178001302 ATP binding site [chemical binding]; other site 444178001303 Q-loop/lid; other site 444178001304 ABC transporter signature motif; other site 444178001305 Walker B; other site 444178001306 D-loop; other site 444178001307 H-loop/switch region; other site 444178001308 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 444178001309 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 444178001310 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178001311 dimer interface [polypeptide binding]; other site 444178001312 conserved gate region; other site 444178001313 ABC-ATPase subunit interface; other site 444178001314 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 444178001315 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178001316 dimer interface [polypeptide binding]; other site 444178001317 conserved gate region; other site 444178001318 putative PBP binding loops; other site 444178001319 ABC-ATPase subunit interface; other site 444178001320 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 444178001321 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 444178001322 peptide binding site [polypeptide binding]; other site 444178001323 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 444178001324 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 444178001325 peptide binding site [polypeptide binding]; other site 444178001326 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 444178001327 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 444178001328 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 444178001329 Predicted integral membrane protein [Function unknown]; Region: COG5455 444178001330 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 444178001331 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 444178001332 NAD binding site [chemical binding]; other site 444178001333 putative substrate binding site 2 [chemical binding]; other site 444178001334 putative substrate binding site 1 [chemical binding]; other site 444178001335 active site 444178001336 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 444178001337 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 444178001338 NAD binding site [chemical binding]; other site 444178001339 homodimer interface [polypeptide binding]; other site 444178001340 active site 444178001341 substrate binding site [chemical binding]; other site 444178001342 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 444178001343 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 444178001344 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 444178001345 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 444178001346 Protein of unknown function (DUF995); Region: DUF995; pfam06191 444178001347 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 444178001348 Protein of unknown function (DUF995); Region: DUF995; pfam06191 444178001349 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 444178001350 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 444178001351 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 444178001352 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 444178001353 Helix-turn-helix domain; Region: HTH_38; pfam13936 444178001354 SEC-C motif; Region: SEC-C; pfam02810 444178001355 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 444178001356 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 444178001357 Homeodomain-like domain; Region: HTH_23; cl17451 444178001358 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 444178001359 Integrase core domain; Region: rve_3; pfam13683 444178001360 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 444178001361 PemK-like protein; Region: PemK; cl00995 444178001362 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 444178001363 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 444178001364 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 444178001365 Walker A/P-loop; other site 444178001366 ATP binding site [chemical binding]; other site 444178001367 Q-loop/lid; other site 444178001368 ABC transporter signature motif; other site 444178001369 Walker B; other site 444178001370 D-loop; other site 444178001371 H-loop/switch region; other site 444178001372 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 444178001373 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 444178001374 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 444178001375 Walker A/P-loop; other site 444178001376 ATP binding site [chemical binding]; other site 444178001377 Q-loop/lid; other site 444178001378 ABC transporter signature motif; other site 444178001379 Walker B; other site 444178001380 D-loop; other site 444178001381 H-loop/switch region; other site 444178001382 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 444178001383 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 444178001384 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178001385 dimer interface [polypeptide binding]; other site 444178001386 conserved gate region; other site 444178001387 putative PBP binding loops; other site 444178001388 ABC-ATPase subunit interface; other site 444178001389 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 444178001390 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178001391 dimer interface [polypeptide binding]; other site 444178001392 conserved gate region; other site 444178001393 putative PBP binding loops; other site 444178001394 ABC-ATPase subunit interface; other site 444178001395 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 444178001396 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 444178001397 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 444178001398 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 444178001399 active site 444178001400 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 444178001401 Homeodomain-like domain; Region: HTH_23; pfam13384 444178001402 Winged helix-turn helix; Region: HTH_29; pfam13551 444178001403 Homeodomain-like domain; Region: HTH_32; pfam13565 444178001404 DDE superfamily endonuclease; Region: DDE_3; pfam13358 444178001405 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 444178001406 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 444178001407 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 444178001408 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 444178001409 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 444178001410 yecA family protein; Region: ygfB_yecA; TIGR02292 444178001411 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 444178001412 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 444178001413 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 444178001414 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 444178001415 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 444178001416 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 444178001417 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 444178001418 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 444178001419 Transposase; Region: HTH_Tnp_1; pfam01527 444178001420 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 444178001421 putative deacylase active site [active] 444178001422 iron-responsive transcriptional regulator; Reviewed; Region: rirA; PRK11920 444178001423 Predicted transcriptional regulator [Transcription]; Region: COG1959 444178001424 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 444178001425 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 444178001426 heme binding site [chemical binding]; other site 444178001427 ferroxidase pore; other site 444178001428 ferroxidase diiron center [ion binding]; other site 444178001429 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 444178001430 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 444178001431 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 444178001432 FeS/SAM binding site; other site 444178001433 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 444178001434 putative ligand binding site [chemical binding]; other site 444178001435 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 444178001436 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 444178001437 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 444178001438 Walker A/P-loop; other site 444178001439 ATP binding site [chemical binding]; other site 444178001440 Q-loop/lid; other site 444178001441 ABC transporter signature motif; other site 444178001442 Walker B; other site 444178001443 D-loop; other site 444178001444 H-loop/switch region; other site 444178001445 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 444178001446 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 444178001447 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 444178001448 TM-ABC transporter signature motif; other site 444178001449 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 444178001450 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 444178001451 TM-ABC transporter signature motif; other site 444178001452 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 444178001453 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 444178001454 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 444178001455 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 444178001456 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494 444178001457 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 444178001458 Uncharacterized conserved protein [Function unknown]; Region: COG3785 444178001459 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 444178001460 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 444178001461 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 444178001462 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 444178001463 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 444178001464 catalytic residues [active] 444178001465 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 444178001466 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 444178001467 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 444178001468 ATP binding site [chemical binding]; other site 444178001469 putative Mg++ binding site [ion binding]; other site 444178001470 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 444178001471 nucleotide binding region [chemical binding]; other site 444178001472 ATP-binding site [chemical binding]; other site 444178001473 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 444178001474 Uncharacterized conserved protein [Function unknown]; Region: COG2938 444178001475 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 444178001476 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 444178001477 generic binding surface II; other site 444178001478 ssDNA binding site; other site 444178001479 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 444178001480 ATP binding site [chemical binding]; other site 444178001481 putative Mg++ binding site [ion binding]; other site 444178001482 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 444178001483 nucleotide binding region [chemical binding]; other site 444178001484 ATP-binding site [chemical binding]; other site 444178001485 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 444178001486 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 444178001487 glutaminase active site [active] 444178001488 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 444178001489 dimer interface [polypeptide binding]; other site 444178001490 active site 444178001491 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 444178001492 dimer interface [polypeptide binding]; other site 444178001493 active site 444178001494 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 444178001495 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 444178001496 Substrate binding site; other site 444178001497 Mg++ binding site; other site 444178001498 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 444178001499 active site 444178001500 substrate binding site [chemical binding]; other site 444178001501 CoA binding site [chemical binding]; other site 444178001502 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 444178001503 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 444178001504 Predicted integral membrane protein [Function unknown]; Region: COG0392 444178001505 Uncharacterized conserved protein [Function unknown]; Region: COG2898 444178001506 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 444178001507 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 444178001508 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 444178001509 BA14K-like protein; Region: BA14K; pfam07886 444178001510 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 444178001511 PAS domain; Region: PAS_9; pfam13426 444178001512 putative active site [active] 444178001513 heme pocket [chemical binding]; other site 444178001514 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 444178001515 PAS fold; Region: PAS_3; pfam08447 444178001516 putative active site [active] 444178001517 heme pocket [chemical binding]; other site 444178001518 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 444178001519 HWE histidine kinase; Region: HWE_HK; pfam07536 444178001520 lipoate-protein ligase B; Provisional; Region: PRK14341 444178001521 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 444178001522 EamA-like transporter family; Region: EamA; pfam00892 444178001523 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 444178001524 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 444178001525 Mg2+ binding site [ion binding]; other site 444178001526 G-X-G motif; other site 444178001527 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 444178001528 anchoring element; other site 444178001529 dimer interface [polypeptide binding]; other site 444178001530 ATP binding site [chemical binding]; other site 444178001531 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 444178001532 active site 444178001533 metal binding site [ion binding]; metal-binding site 444178001534 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 444178001535 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 444178001536 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 444178001537 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 444178001538 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 444178001539 metal-dependent hydrolase; Provisional; Region: PRK00685 444178001540 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 444178001541 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 444178001542 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 444178001543 active site 444178001544 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 444178001545 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 444178001546 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 444178001547 dihydroorotase; Validated; Region: PRK09059 444178001548 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 444178001549 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 444178001550 active site 444178001551 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 444178001552 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 444178001553 DNA protecting protein DprA; Region: dprA; TIGR00732 444178001554 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 444178001555 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 444178001556 active site 444178001557 interdomain interaction site; other site 444178001558 putative metal-binding site [ion binding]; other site 444178001559 nucleotide binding site [chemical binding]; other site 444178001560 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 444178001561 domain I; other site 444178001562 DNA binding groove [nucleotide binding] 444178001563 phosphate binding site [ion binding]; other site 444178001564 domain II; other site 444178001565 domain III; other site 444178001566 nucleotide binding site [chemical binding]; other site 444178001567 catalytic site [active] 444178001568 domain IV; other site 444178001569 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 444178001570 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 444178001571 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 444178001572 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 444178001573 ribonuclease R; Region: RNase_R; TIGR02063 444178001574 RNB domain; Region: RNB; pfam00773 444178001575 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 444178001576 RNA binding site [nucleotide binding]; other site 444178001577 hypothetical protein; Provisional; Region: PRK05978 444178001578 Major Facilitator Superfamily; Region: MFS_1; pfam07690 444178001579 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 444178001580 putative substrate translocation pore; other site 444178001581 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 444178001582 response regulator PleD; Reviewed; Region: pleD; PRK09581 444178001583 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 444178001584 active site 444178001585 phosphorylation site [posttranslational modification] 444178001586 intermolecular recognition site; other site 444178001587 dimerization interface [polypeptide binding]; other site 444178001588 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 444178001589 active site 444178001590 phosphorylation site [posttranslational modification] 444178001591 intermolecular recognition site; other site 444178001592 dimerization interface [polypeptide binding]; other site 444178001593 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 444178001594 metal binding site [ion binding]; metal-binding site 444178001595 active site 444178001596 I-site; other site 444178001597 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 444178001598 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 444178001599 active site 444178001600 phosphorylation site [posttranslational modification] 444178001601 intermolecular recognition site; other site 444178001602 dimerization interface [polypeptide binding]; other site 444178001603 Protein of unknown function (DUF3572); Region: DUF3572; pfam12096 444178001604 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 444178001605 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 444178001606 DNA polymerase IV; Provisional; Region: PRK02794 444178001607 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 444178001608 active site 444178001609 DNA binding site [nucleotide binding] 444178001610 Uncharacterized conserved protein [Function unknown]; Region: COG3391 444178001611 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 444178001612 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 444178001613 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 444178001614 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 444178001615 active site 444178001616 catalytic site [active] 444178001617 substrate binding site [chemical binding]; other site 444178001618 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 444178001619 Helix-turn-helix domain; Region: HTH_18; pfam12833 444178001620 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 444178001621 hydroxyglutarate oxidase; Provisional; Region: PRK11728 444178001622 hydroxyglutarate oxidase; Provisional; Region: PRK11728 444178001623 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 444178001624 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 444178001625 substrate binding pocket [chemical binding]; other site 444178001626 membrane-bound complex binding site; other site 444178001627 hinge residues; other site 444178001628 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 444178001629 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 444178001630 substrate binding pocket [chemical binding]; other site 444178001631 membrane-bound complex binding site; other site 444178001632 hinge residues; other site 444178001633 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 444178001634 putative DNA binding site [nucleotide binding]; other site 444178001635 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 444178001636 putative Zn2+ binding site [ion binding]; other site 444178001637 AsnC family; Region: AsnC_trans_reg; pfam01037 444178001638 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 444178001639 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 444178001640 active site 444178001641 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 444178001642 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 444178001643 dimer interface [polypeptide binding]; other site 444178001644 active site 444178001645 Coenzyme A transferase; Region: CoA_trans; cl17247 444178001646 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 444178001647 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 444178001648 Bacterial transcriptional regulator; Region: IclR; pfam01614 444178001649 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 444178001650 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 444178001651 hypothetical protein; Provisional; Region: PRK07236 444178001652 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 444178001653 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 444178001654 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 444178001655 dimerization interface [polypeptide binding]; other site 444178001656 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 444178001657 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 444178001658 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 444178001659 heterodimer interface [polypeptide binding]; other site 444178001660 active site 444178001661 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 444178001662 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 444178001663 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 444178001664 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 444178001665 TM-ABC transporter signature motif; other site 444178001666 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 444178001667 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 444178001668 Walker A/P-loop; other site 444178001669 ATP binding site [chemical binding]; other site 444178001670 Q-loop/lid; other site 444178001671 ABC transporter signature motif; other site 444178001672 Walker B; other site 444178001673 D-loop; other site 444178001674 H-loop/switch region; other site 444178001675 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 444178001676 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 444178001677 Walker A/P-loop; other site 444178001678 ATP binding site [chemical binding]; other site 444178001679 Q-loop/lid; other site 444178001680 ABC transporter signature motif; other site 444178001681 Walker B; other site 444178001682 D-loop; other site 444178001683 H-loop/switch region; other site 444178001684 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 444178001685 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 444178001686 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 444178001687 active site 444178001688 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 444178001689 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 444178001690 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 444178001691 active site 444178001692 dimer interface [polypeptide binding]; other site 444178001693 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 444178001694 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 444178001695 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 444178001696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 444178001697 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 444178001698 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178001699 dimer interface [polypeptide binding]; other site 444178001700 conserved gate region; other site 444178001701 ABC-ATPase subunit interface; other site 444178001702 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 444178001703 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 444178001704 Walker A/P-loop; other site 444178001705 ATP binding site [chemical binding]; other site 444178001706 Q-loop/lid; other site 444178001707 ABC transporter signature motif; other site 444178001708 Walker B; other site 444178001709 D-loop; other site 444178001710 H-loop/switch region; other site 444178001711 TOBE domain; Region: TOBE_2; pfam08402 444178001712 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 444178001713 transmembrane helices; other site 444178001714 TrkA-C domain; Region: TrkA_C; pfam02080 444178001715 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 444178001716 TrkA-C domain; Region: TrkA_C; pfam02080 444178001717 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 444178001718 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 444178001719 nucleoside/Zn binding site; other site 444178001720 dimer interface [polypeptide binding]; other site 444178001721 catalytic motif [active] 444178001722 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 444178001723 aminotransferase; Provisional; Region: PRK13356 444178001724 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 444178001725 homodimer interface [polypeptide binding]; other site 444178001726 substrate-cofactor binding pocket; other site 444178001727 pyridoxal 5'-phosphate binding site [chemical binding]; other site 444178001728 catalytic residue [active] 444178001729 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 444178001730 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 444178001731 FAD binding domain; Region: FAD_binding_2; pfam00890 444178001732 Protein of unknown function (DUF3775); Region: DUF3775; pfam12616 444178001733 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 444178001734 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 444178001735 NAD binding site [chemical binding]; other site 444178001736 catalytic residues [active] 444178001737 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 444178001738 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 444178001739 putative ligand binding residues [chemical binding]; other site 444178001740 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 444178001741 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 444178001742 ABC-ATPase subunit interface; other site 444178001743 dimer interface [polypeptide binding]; other site 444178001744 putative PBP binding regions; other site 444178001745 ABC-type enterochelin transport system, permease component [Inorganic ion transport and metabolism]; Region: CeuC; COG4605 444178001746 ABC-ATPase subunit interface; other site 444178001747 dimer interface [polypeptide binding]; other site 444178001748 putative PBP binding regions; other site 444178001749 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 444178001750 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 444178001751 Walker A/P-loop; other site 444178001752 ATP binding site [chemical binding]; other site 444178001753 Q-loop/lid; other site 444178001754 ABC transporter signature motif; other site 444178001755 Walker B; other site 444178001756 D-loop; other site 444178001757 H-loop/switch region; other site 444178001758 Predicted transcription regulator, contains HTH domain (MarR family) [Transcription]; Region: COG5631 444178001759 5-oxoprolinase; Region: PLN02666 444178001760 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 444178001761 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 444178001762 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 444178001763 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 444178001764 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 444178001765 substrate binding pocket [chemical binding]; other site 444178001766 membrane-bound complex binding site; other site 444178001767 hinge residues; other site 444178001768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178001769 dimer interface [polypeptide binding]; other site 444178001770 conserved gate region; other site 444178001771 putative PBP binding loops; other site 444178001772 ABC-ATPase subunit interface; other site 444178001773 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 444178001774 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 444178001775 Walker A/P-loop; other site 444178001776 ATP binding site [chemical binding]; other site 444178001777 Q-loop/lid; other site 444178001778 ABC transporter signature motif; other site 444178001779 Walker B; other site 444178001780 D-loop; other site 444178001781 H-loop/switch region; other site 444178001782 exopolyphosphatase; Region: exo_poly_only; TIGR03706 444178001783 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 444178001784 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 444178001785 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 444178001786 S-adenosylmethionine binding site [chemical binding]; other site 444178001787 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 444178001788 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 444178001789 Walker A/P-loop; other site 444178001790 ATP binding site [chemical binding]; other site 444178001791 Q-loop/lid; other site 444178001792 ABC transporter signature motif; other site 444178001793 Walker B; other site 444178001794 D-loop; other site 444178001795 H-loop/switch region; other site 444178001796 TOBE domain; Region: TOBE_2; pfam08402 444178001797 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 444178001798 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178001799 dimer interface [polypeptide binding]; other site 444178001800 conserved gate region; other site 444178001801 putative PBP binding loops; other site 444178001802 ABC-ATPase subunit interface; other site 444178001803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178001804 dimer interface [polypeptide binding]; other site 444178001805 conserved gate region; other site 444178001806 putative PBP binding loops; other site 444178001807 ABC-ATPase subunit interface; other site 444178001808 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-II; Region: Lumazine_synthase-II; cd09208 444178001809 active site 444178001810 homopentamer interface [polypeptide binding]; other site 444178001811 dimer interface [polypeptide binding]; other site 444178001812 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3453 444178001813 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 444178001814 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178001815 dimer interface [polypeptide binding]; other site 444178001816 conserved gate region; other site 444178001817 putative PBP binding loops; other site 444178001818 ABC-ATPase subunit interface; other site 444178001819 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178001820 dimer interface [polypeptide binding]; other site 444178001821 conserved gate region; other site 444178001822 putative PBP binding loops; other site 444178001823 ABC-ATPase subunit interface; other site 444178001824 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 444178001825 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 444178001826 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 444178001827 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 444178001828 Walker A/P-loop; other site 444178001829 ATP binding site [chemical binding]; other site 444178001830 Q-loop/lid; other site 444178001831 ABC transporter signature motif; other site 444178001832 Walker B; other site 444178001833 D-loop; other site 444178001834 H-loop/switch region; other site 444178001835 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 444178001836 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 444178001837 E-class dimer interface [polypeptide binding]; other site 444178001838 P-class dimer interface [polypeptide binding]; other site 444178001839 active site 444178001840 Cu2+ binding site [ion binding]; other site 444178001841 Zn2+ binding site [ion binding]; other site 444178001842 multicopper oxidase; Provisional; Region: PRK10965 444178001843 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 444178001844 Multicopper oxidase; Region: Cu-oxidase; pfam00394 444178001845 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 444178001846 metabolite-proton symporter; Region: 2A0106; TIGR00883 444178001847 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 444178001848 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 444178001849 dimer interface [polypeptide binding]; other site 444178001850 decamer (pentamer of dimers) interface [polypeptide binding]; other site 444178001851 catalytic triad [active] 444178001852 peroxidatic and resolving cysteines [active] 444178001853 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 444178001854 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 444178001855 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 444178001856 dimerization interface [polypeptide binding]; other site 444178001857 Protein of unknown function (DUF1612); Region: DUF1612; pfam07756 444178001858 HTH DNA binding domain; Region: HTH_13; pfam11972 444178001859 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 444178001860 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 444178001861 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 444178001862 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 444178001863 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 444178001864 PYR/PP interface [polypeptide binding]; other site 444178001865 dimer interface [polypeptide binding]; other site 444178001866 TPP binding site [chemical binding]; other site 444178001867 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 444178001868 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 444178001869 TPP-binding site [chemical binding]; other site 444178001870 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 444178001871 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 444178001872 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 444178001873 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 444178001874 active site 444178001875 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 444178001876 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 444178001877 Walker A/P-loop; other site 444178001878 ATP binding site [chemical binding]; other site 444178001879 Q-loop/lid; other site 444178001880 ABC transporter signature motif; other site 444178001881 Walker B; other site 444178001882 D-loop; other site 444178001883 H-loop/switch region; other site 444178001884 TOBE domain; Region: TOBE_2; pfam08402 444178001885 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 444178001886 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178001887 dimer interface [polypeptide binding]; other site 444178001888 conserved gate region; other site 444178001889 putative PBP binding loops; other site 444178001890 ABC-ATPase subunit interface; other site 444178001891 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178001892 dimer interface [polypeptide binding]; other site 444178001893 conserved gate region; other site 444178001894 putative PBP binding loops; other site 444178001895 ABC-ATPase subunit interface; other site 444178001896 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 444178001897 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 444178001898 glycine dehydrogenase; Provisional; Region: PRK05367 444178001899 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 444178001900 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 444178001901 catalytic residue [active] 444178001902 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 444178001903 tetramer interface [polypeptide binding]; other site 444178001904 pyridoxal 5'-phosphate binding site [chemical binding]; other site 444178001905 catalytic residue [active] 444178001906 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 444178001907 lipoyl attachment site [posttranslational modification]; other site 444178001908 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 444178001909 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 444178001910 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 444178001911 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 444178001912 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 444178001913 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 444178001914 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 444178001915 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 444178001916 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 444178001917 putative active site [active] 444178001918 Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931 444178001919 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 444178001920 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 444178001921 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 444178001922 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 444178001923 putative active site [active] 444178001924 metal binding site [ion binding]; metal-binding site 444178001925 BA14K-like protein; Region: BA14K; pfam07886 444178001926 EamA-like transporter family; Region: EamA; pfam00892 444178001927 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178001928 dimer interface [polypeptide binding]; other site 444178001929 conserved gate region; other site 444178001930 putative PBP binding loops; other site 444178001931 ABC-ATPase subunit interface; other site 444178001932 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 444178001933 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 444178001934 Walker A/P-loop; other site 444178001935 ATP binding site [chemical binding]; other site 444178001936 Q-loop/lid; other site 444178001937 ABC transporter signature motif; other site 444178001938 Walker B; other site 444178001939 D-loop; other site 444178001940 H-loop/switch region; other site 444178001941 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 444178001942 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 444178001943 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 444178001944 dimer interface [polypeptide binding]; other site 444178001945 active site 444178001946 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 444178001947 substrate binding site [chemical binding]; other site 444178001948 catalytic residue [active] 444178001949 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 444178001950 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 444178001951 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 444178001952 putative active site [active] 444178001953 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 444178001954 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 444178001955 Walker A/P-loop; other site 444178001956 ATP binding site [chemical binding]; other site 444178001957 Q-loop/lid; other site 444178001958 ABC transporter signature motif; other site 444178001959 Walker B; other site 444178001960 D-loop; other site 444178001961 H-loop/switch region; other site 444178001962 TOBE domain; Region: TOBE; pfam03459 444178001963 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 444178001964 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 444178001965 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178001966 dimer interface [polypeptide binding]; other site 444178001967 conserved gate region; other site 444178001968 putative PBP binding loops; other site 444178001969 ABC-ATPase subunit interface; other site 444178001970 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 444178001971 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178001972 dimer interface [polypeptide binding]; other site 444178001973 conserved gate region; other site 444178001974 putative PBP binding loops; other site 444178001975 ABC-ATPase subunit interface; other site 444178001976 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 444178001977 homotrimer interaction site [polypeptide binding]; other site 444178001978 putative active site [active] 444178001979 Uncharacterized conserved protein [Function unknown]; Region: COG5476 444178001980 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 444178001981 MlrC C-terminus; Region: MlrC_C; pfam07171 444178001982 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 444178001983 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 444178001984 Walker A/P-loop; other site 444178001985 ATP binding site [chemical binding]; other site 444178001986 Q-loop/lid; other site 444178001987 ABC transporter signature motif; other site 444178001988 Walker B; other site 444178001989 D-loop; other site 444178001990 H-loop/switch region; other site 444178001991 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 444178001992 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 444178001993 ABC-ATPase subunit interface; other site 444178001994 dimer interface [polypeptide binding]; other site 444178001995 putative PBP binding regions; other site 444178001996 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 444178001997 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 444178001998 putative ligand binding residues [chemical binding]; other site 444178001999 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 444178002000 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 444178002001 HlyD family secretion protein; Region: HlyD_3; pfam13437 444178002002 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 444178002003 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 444178002004 MarR family; Region: MarR_2; pfam12802 444178002005 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 444178002006 RNA methyltransferase, RsmE family; Region: TIGR00046 444178002007 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 444178002008 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 444178002009 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 444178002010 generic binding surface II; other site 444178002011 generic binding surface I; other site 444178002012 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 444178002013 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 444178002014 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 444178002015 hypothetical protein; Reviewed; Region: PRK12275 444178002016 four helix bundle protein; Region: TIGR02436 444178002017 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 444178002018 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 444178002019 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 444178002020 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 444178002021 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 444178002022 Hint domain; Region: Hint_2; pfam13403 444178002023 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 444178002024 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 444178002025 putative DNA binding site [nucleotide binding]; other site 444178002026 putative Zn2+ binding site [ion binding]; other site 444178002027 AsnC family; Region: AsnC_trans_reg; pfam01037 444178002028 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 444178002029 Predicted membrane protein [Function unknown]; Region: COG4541 444178002030 drug efflux system protein MdtG; Provisional; Region: PRK09874 444178002031 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 444178002032 putative substrate translocation pore; other site 444178002033 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345 444178002034 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 444178002035 putative NAD(P) binding site [chemical binding]; other site 444178002036 active site 444178002037 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 444178002038 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 444178002039 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 444178002040 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 444178002041 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 444178002042 putative active site [active] 444178002043 phosphogluconate dehydratase; Validated; Region: PRK09054 444178002044 6-phosphogluconate dehydratase; Region: edd; TIGR01196 444178002045 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 444178002046 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 444178002047 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 444178002048 homodimer interface [polypeptide binding]; other site 444178002049 NADP binding site [chemical binding]; other site 444178002050 substrate binding site [chemical binding]; other site 444178002051 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 444178002052 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 444178002053 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 444178002054 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 444178002055 Walker A/P-loop; other site 444178002056 ATP binding site [chemical binding]; other site 444178002057 Q-loop/lid; other site 444178002058 ABC transporter signature motif; other site 444178002059 Walker B; other site 444178002060 D-loop; other site 444178002061 H-loop/switch region; other site 444178002062 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 444178002063 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178002064 conserved gate region; other site 444178002065 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 444178002066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178002067 dimer interface [polypeptide binding]; other site 444178002068 conserved gate region; other site 444178002069 putative PBP binding loops; other site 444178002070 ABC-ATPase subunit interface; other site 444178002071 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 444178002072 active site clefts [active] 444178002073 zinc binding site [ion binding]; other site 444178002074 dimer interface [polypeptide binding]; other site 444178002075 tellurite resistance protein terB; Region: terB; cd07176 444178002076 putative metal binding site [ion binding]; other site 444178002077 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 444178002078 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 444178002079 active site 444178002080 nucleotide binding site [chemical binding]; other site 444178002081 HIGH motif; other site 444178002082 KMSKS motif; other site 444178002083 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 444178002084 Predicted transcriptional regulator [Transcription]; Region: COG2932 444178002085 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 444178002086 Catalytic site [active] 444178002087 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 444178002088 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 444178002089 substrate binding site [chemical binding]; other site 444178002090 oxyanion hole (OAH) forming residues; other site 444178002091 trimer interface [polypeptide binding]; other site 444178002092 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 444178002093 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 444178002094 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 444178002095 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 444178002096 dimer interface [polypeptide binding]; other site 444178002097 active site 444178002098 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 444178002099 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 444178002100 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 444178002101 FAD binding site [chemical binding]; other site 444178002102 substrate binding site [chemical binding]; other site 444178002103 catalytic residues [active] 444178002104 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 444178002105 Transcriptional regulator [Transcription]; Region: LysR; COG0583 444178002106 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 444178002107 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 444178002108 putative dimerization interface [polypeptide binding]; other site 444178002109 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 444178002110 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 444178002111 active site 444178002112 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 444178002113 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 444178002114 Walker A/P-loop; other site 444178002115 ATP binding site [chemical binding]; other site 444178002116 Q-loop/lid; other site 444178002117 ABC transporter signature motif; other site 444178002118 Walker B; other site 444178002119 D-loop; other site 444178002120 H-loop/switch region; other site 444178002121 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 444178002122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178002123 dimer interface [polypeptide binding]; other site 444178002124 conserved gate region; other site 444178002125 putative PBP binding loops; other site 444178002126 ABC-ATPase subunit interface; other site 444178002127 nickel transporter permease NikB; Provisional; Region: PRK10352 444178002128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178002129 dimer interface [polypeptide binding]; other site 444178002130 conserved gate region; other site 444178002131 putative PBP binding loops; other site 444178002132 ABC-ATPase subunit interface; other site 444178002133 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 444178002134 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 444178002135 substrate binding site [chemical binding]; other site 444178002136 nickel responsive regulator; Provisional; Region: PRK02967 444178002137 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 444178002138 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 444178002139 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 444178002140 galactarate dehydratase; Region: galactar-dH20; TIGR03248 444178002141 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 444178002142 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 444178002143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178002144 dimer interface [polypeptide binding]; other site 444178002145 conserved gate region; other site 444178002146 putative PBP binding loops; other site 444178002147 ABC-ATPase subunit interface; other site 444178002148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178002149 putative PBP binding loops; other site 444178002150 ABC-ATPase subunit interface; other site 444178002151 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 444178002152 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 444178002153 Walker A/P-loop; other site 444178002154 ATP binding site [chemical binding]; other site 444178002155 Q-loop/lid; other site 444178002156 ABC transporter signature motif; other site 444178002157 Walker B; other site 444178002158 D-loop; other site 444178002159 H-loop/switch region; other site 444178002160 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 444178002161 hypothetical protein; Provisional; Region: PRK11622 444178002162 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 444178002163 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 444178002164 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 444178002165 Transcriptional regulators [Transcription]; Region: GntR; COG1802 444178002166 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 444178002167 DNA-binding site [nucleotide binding]; DNA binding site 444178002168 FCD domain; Region: FCD; pfam07729 444178002169 mannonate dehydratase; Region: uxuA; TIGR00695 444178002170 mannonate dehydratase; Provisional; Region: PRK03906 444178002171 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 444178002172 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 444178002173 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 444178002174 HlyD family secretion protein; Region: HlyD_3; pfam13437 444178002175 camphor resistance protein CrcB; Provisional; Region: PRK14233 444178002176 camphor resistance protein CrcB; Provisional; Region: PRK14225 444178002177 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 444178002178 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 444178002179 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 444178002180 DNA binding residues [nucleotide binding] 444178002181 putative dimer interface [polypeptide binding]; other site 444178002182 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 444178002183 Sel1-like repeats; Region: SEL1; smart00671 444178002184 Sel1-like repeats; Region: SEL1; smart00671 444178002185 Sel1-like repeats; Region: SEL1; smart00671 444178002186 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 444178002187 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 444178002188 conserved hypothetical protein; Region: alph_Pro_TM; TIGR02186 444178002189 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 444178002190 putative active site [active] 444178002191 putative metal binding site [ion binding]; other site 444178002192 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 444178002193 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 444178002194 FMN binding site [chemical binding]; other site 444178002195 substrate binding site [chemical binding]; other site 444178002196 putative catalytic residue [active] 444178002197 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 444178002198 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 444178002199 HsdM N-terminal domain; Region: HsdM_N; pfam12161 444178002200 Methyltransferase domain; Region: Methyltransf_26; pfam13659 444178002201 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 444178002202 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 444178002203 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 444178002204 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 444178002205 ATP binding site [chemical binding]; other site 444178002206 putative Mg++ binding site [ion binding]; other site 444178002207 helicase superfamily c-terminal domain; Region: HELICc; smart00490 444178002208 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 444178002209 Protein of unknown function DUF45; Region: DUF45; pfam01863 444178002210 Protein of unknown function DUF91; Region: DUF91; cl00709 444178002211 Uncharacterized conserved protein [Function unknown]; Region: COG3586 444178002212 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 444178002213 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 444178002214 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 444178002215 inhibitor-cofactor binding pocket; inhibition site 444178002216 pyridoxal 5'-phosphate binding site [chemical binding]; other site 444178002217 catalytic residue [active] 444178002218 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 444178002219 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 444178002220 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 444178002221 FAD binding domain; Region: FAD_binding_4; pfam01565 444178002222 hypothetical protein; Validated; Region: PRK08238 444178002223 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 444178002224 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 444178002225 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 444178002226 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 444178002227 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 444178002228 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 444178002229 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 444178002230 Walker A/P-loop; other site 444178002231 ATP binding site [chemical binding]; other site 444178002232 Q-loop/lid; other site 444178002233 ABC transporter signature motif; other site 444178002234 Walker B; other site 444178002235 D-loop; other site 444178002236 H-loop/switch region; other site 444178002237 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 444178002238 Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; pfam10054 444178002239 glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369 444178002240 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 444178002241 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 444178002242 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 444178002243 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 444178002244 triosephosphate isomerase; Provisional; Region: PRK14565 444178002245 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 444178002246 substrate binding site [chemical binding]; other site 444178002247 dimer interface [polypeptide binding]; other site 444178002248 catalytic triad [active] 444178002249 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 444178002250 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 444178002251 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 444178002252 intersubunit interface [polypeptide binding]; other site 444178002253 active site 444178002254 zinc binding site [ion binding]; other site 444178002255 Na+ binding site [ion binding]; other site 444178002256 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 444178002257 AMP binding site [chemical binding]; other site 444178002258 metal binding site [ion binding]; metal-binding site 444178002259 active site 444178002260 Uncharacterized conserved protein [Function unknown]; Region: COG1739 444178002261 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 444178002262 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 444178002263 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 444178002264 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 444178002265 G1 box; other site 444178002266 putative GEF interaction site [polypeptide binding]; other site 444178002267 GTP/Mg2+ binding site [chemical binding]; other site 444178002268 Switch I region; other site 444178002269 G2 box; other site 444178002270 G3 box; other site 444178002271 Switch II region; other site 444178002272 G4 box; other site 444178002273 G5 box; other site 444178002274 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 444178002275 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 444178002276 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 444178002277 MgtE intracellular N domain; Region: MgtE_N; pfam03448 444178002278 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 444178002279 Divalent cation transporter; Region: MgtE; pfam01769 444178002280 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 444178002281 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 444178002282 active site 444178002283 Zn binding site [ion binding]; other site 444178002284 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 444178002285 dimer interface [polypeptide binding]; other site 444178002286 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 444178002287 Uncharacterized conserved small protein [Function unknown]; Region: COG5515 444178002288 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 444178002289 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 444178002290 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 444178002291 substrate binding site [chemical binding]; other site 444178002292 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 444178002293 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 444178002294 Transcriptional regulators [Transcription]; Region: MarR; COG1846 444178002295 MarR family; Region: MarR; pfam01047 444178002296 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 444178002297 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 444178002298 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 444178002299 putative substrate translocation pore; other site 444178002300 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 444178002301 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 444178002302 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 444178002303 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 444178002304 DNA binding site [nucleotide binding] 444178002305 active site 444178002306 tartrate dehydrogenase; Region: TTC; TIGR02089 444178002307 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 444178002308 Uncharacterized conserved protein [Function unknown]; Region: COG2835 444178002309 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 444178002310 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 444178002311 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 444178002312 catalytic residues [active] 444178002313 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 444178002314 putative deacylase active site [active] 444178002315 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 444178002316 apolar tunnel; other site 444178002317 heme binding site [chemical binding]; other site 444178002318 dimerization interface [polypeptide binding]; other site 444178002319 ornithine cyclodeaminase; Validated; Region: PRK07589 444178002320 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 444178002321 Arginase family; Region: Arginase; cd09989 444178002322 agmatinase; Region: agmatinase; TIGR01230 444178002323 active site 444178002324 Mn binding site [ion binding]; other site 444178002325 oligomer interface [polypeptide binding]; other site 444178002326 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 444178002327 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 444178002328 AsnC family; Region: AsnC_trans_reg; pfam01037 444178002329 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 444178002330 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 444178002331 FMN binding site [chemical binding]; other site 444178002332 active site 444178002333 substrate binding site [chemical binding]; other site 444178002334 catalytic residue [active] 444178002335 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 444178002336 dimerization interface [polypeptide binding]; other site 444178002337 putative DNA binding site [nucleotide binding]; other site 444178002338 putative Zn2+ binding site [ion binding]; other site 444178002339 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 444178002340 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 444178002341 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 444178002342 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 444178002343 aldehyde dehydrogenase family 7 member; Region: PLN02315 444178002344 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 444178002345 tetrameric interface [polypeptide binding]; other site 444178002346 NAD binding site [chemical binding]; other site 444178002347 catalytic residues [active] 444178002348 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 444178002349 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 444178002350 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 444178002351 putative active site [active] 444178002352 putative substrate binding site [chemical binding]; other site 444178002353 putative cosubstrate binding site; other site 444178002354 catalytic site [active] 444178002355 hypothetical protein; Provisional; Region: PRK02947 444178002356 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 444178002357 putative active site [active] 444178002358 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 444178002359 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 444178002360 active site 444178002361 dimer interface [polypeptide binding]; other site 444178002362 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 444178002363 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 444178002364 dimer interface [polypeptide binding]; other site 444178002365 active site 444178002366 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 444178002367 dimer interface [polypeptide binding]; other site 444178002368 active site 444178002369 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 444178002370 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 444178002371 DNA-binding site [nucleotide binding]; DNA binding site 444178002372 UTRA domain; Region: UTRA; pfam07702 444178002373 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 444178002374 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 444178002375 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 444178002376 HlyD family secretion protein; Region: HlyD_3; pfam13437 444178002377 putative membrane fusion protein; Region: TIGR02828 444178002378 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 444178002379 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 444178002380 phosphate binding site [ion binding]; other site 444178002381 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 444178002382 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 444178002383 AsnC family; Region: AsnC_trans_reg; pfam01037 444178002384 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 444178002385 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 444178002386 active site 444178002387 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 444178002388 dimer interface [polypeptide binding]; other site 444178002389 substrate binding site [chemical binding]; other site 444178002390 catalytic residues [active] 444178002391 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 444178002392 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 444178002393 hydroxyglutarate oxidase; Provisional; Region: PRK11728 444178002394 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 444178002395 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 444178002396 non-specific DNA binding site [nucleotide binding]; other site 444178002397 salt bridge; other site 444178002398 sequence-specific DNA binding site [nucleotide binding]; other site 444178002399 Cupin domain; Region: Cupin_2; pfam07883 444178002400 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 444178002401 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 444178002402 inhibitor-cofactor binding pocket; inhibition site 444178002403 pyridoxal 5'-phosphate binding site [chemical binding]; other site 444178002404 catalytic residue [active] 444178002405 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 444178002406 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 444178002407 DNA-binding site [nucleotide binding]; DNA binding site 444178002408 UTRA domain; Region: UTRA; pfam07702 444178002409 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 444178002410 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 444178002411 active site 444178002412 imidazolonepropionase; Validated; Region: PRK09356 444178002413 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 444178002414 active site 444178002415 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 444178002416 active sites [active] 444178002417 tetramer interface [polypeptide binding]; other site 444178002418 N-formylglutamate amidohydrolase; Region: hutG_amidohyd; TIGR02017 444178002419 urocanate hydratase; Provisional; Region: PRK05414 444178002420 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3758 444178002421 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 444178002422 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 444178002423 homodimer interface [polypeptide binding]; other site 444178002424 substrate-cofactor binding pocket; other site 444178002425 pyridoxal 5'-phosphate binding site [chemical binding]; other site 444178002426 catalytic residue [active] 444178002427 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 444178002428 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 444178002429 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 444178002430 TM-ABC transporter signature motif; other site 444178002431 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 444178002432 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 444178002433 Walker A/P-loop; other site 444178002434 ATP binding site [chemical binding]; other site 444178002435 Q-loop/lid; other site 444178002436 ABC transporter signature motif; other site 444178002437 Walker B; other site 444178002438 D-loop; other site 444178002439 H-loop/switch region; other site 444178002440 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 444178002441 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 444178002442 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 444178002443 putative ligand binding site [chemical binding]; other site 444178002444 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 444178002445 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 444178002446 active site 444178002447 intersubunit interface [polypeptide binding]; other site 444178002448 catalytic residue [active] 444178002449 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 444178002450 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 444178002451 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 444178002452 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 444178002453 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 444178002454 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 444178002455 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 444178002456 Transcriptional regulators [Transcription]; Region: FadR; COG2186 444178002457 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 444178002458 DNA-binding site [nucleotide binding]; DNA binding site 444178002459 FCD domain; Region: FCD; pfam07729 444178002460 D-aminopeptidase; Reviewed; Region: PRK13128 444178002461 Beta-lactamase; Region: Beta-lactamase; pfam00144 444178002462 D-aminopeptidase, domain B; Region: DAP_B; pfam07930 444178002463 D-aminopeptidase, domain C; Region: DAP_C; pfam07932 444178002464 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 444178002465 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 444178002466 substrate binding pocket [chemical binding]; other site 444178002467 membrane-bound complex binding site; other site 444178002468 hinge residues; other site 444178002469 hypothetical protein; Provisional; Region: PRK06148 444178002470 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 444178002471 active site 444178002472 substrate binding site [chemical binding]; other site 444178002473 ATP binding site [chemical binding]; other site 444178002474 Peptidase family M23; Region: Peptidase_M23; pfam01551 444178002475 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 444178002476 inhibitor-cofactor binding pocket; inhibition site 444178002477 pyridoxal 5'-phosphate binding site [chemical binding]; other site 444178002478 catalytic residue [active] 444178002479 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 444178002480 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 444178002481 AsnC family; Region: AsnC_trans_reg; pfam01037 444178002482 Transcriptional regulator [Transcription]; Region: LysR; COG0583 444178002483 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 444178002484 LysR substrate binding domain; Region: LysR_substrate; pfam03466 444178002485 dimerization interface [polypeptide binding]; other site 444178002486 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 444178002487 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 444178002488 putative ligand binding site [chemical binding]; other site 444178002489 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 444178002490 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 444178002491 Walker A/P-loop; other site 444178002492 ATP binding site [chemical binding]; other site 444178002493 Q-loop/lid; other site 444178002494 ABC transporter signature motif; other site 444178002495 Walker B; other site 444178002496 D-loop; other site 444178002497 H-loop/switch region; other site 444178002498 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 444178002499 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 444178002500 Walker A/P-loop; other site 444178002501 ATP binding site [chemical binding]; other site 444178002502 Q-loop/lid; other site 444178002503 ABC transporter signature motif; other site 444178002504 Walker B; other site 444178002505 D-loop; other site 444178002506 H-loop/switch region; other site 444178002507 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 444178002508 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 444178002509 TM-ABC transporter signature motif; other site 444178002510 choline dehydrogenase; Validated; Region: PRK02106 444178002511 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 444178002512 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 444178002513 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 444178002514 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 444178002515 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 444178002516 Walker A/P-loop; other site 444178002517 ATP binding site [chemical binding]; other site 444178002518 Q-loop/lid; other site 444178002519 ABC transporter signature motif; other site 444178002520 Walker B; other site 444178002521 D-loop; other site 444178002522 H-loop/switch region; other site 444178002523 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 444178002524 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178002525 dimer interface [polypeptide binding]; other site 444178002526 conserved gate region; other site 444178002527 ABC-ATPase subunit interface; other site 444178002528 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 444178002529 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 444178002530 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 444178002531 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 444178002532 TPR motif; other site 444178002533 binding surface 444178002534 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 444178002535 binding surface 444178002536 TPR motif; other site 444178002537 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 444178002538 binding surface 444178002539 TPR motif; other site 444178002540 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 444178002541 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 444178002542 putative active site [active] 444178002543 putative catalytic site [active] 444178002544 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 444178002545 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 444178002546 active site 444178002547 motif I; other site 444178002548 motif II; other site 444178002549 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 444178002550 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 444178002551 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 444178002552 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 444178002553 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 444178002554 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 444178002555 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 444178002556 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 444178002557 ligand binding site [chemical binding]; other site 444178002558 homodimer interface [polypeptide binding]; other site 444178002559 NAD(P) binding site [chemical binding]; other site 444178002560 trimer interface B [polypeptide binding]; other site 444178002561 trimer interface A [polypeptide binding]; other site 444178002562 Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835 444178002563 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 444178002564 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 444178002565 Beta-lactamase; Region: Beta-lactamase; pfam00144 444178002566 PAS fold; Region: PAS_7; pfam12860 444178002567 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 444178002568 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 444178002569 metal binding site [ion binding]; metal-binding site 444178002570 active site 444178002571 I-site; other site 444178002572 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 444178002573 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 444178002574 classical (c) SDRs; Region: SDR_c; cd05233 444178002575 NAD(P) binding site [chemical binding]; other site 444178002576 active site 444178002577 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 444178002578 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 444178002579 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 444178002580 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 444178002581 catalytic triad [active] 444178002582 D-lactate dehydrogenase; Validated; Region: PRK08605 444178002583 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 444178002584 putative ligand binding site [chemical binding]; other site 444178002585 NAD binding site [chemical binding]; other site 444178002586 catalytic site [active] 444178002587 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 444178002588 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 444178002589 Transcriptional regulators [Transcription]; Region: PurR; COG1609 444178002590 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 444178002591 DNA binding site [nucleotide binding] 444178002592 domain linker motif; other site 444178002593 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 444178002594 putative dimerization interface [polypeptide binding]; other site 444178002595 putative ligand binding site [chemical binding]; other site 444178002596 Creatinine amidohydrolase; Region: Creatininase; pfam02633 444178002597 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 444178002598 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 444178002599 P-loop, Walker A motif; other site 444178002600 Base recognition motif; other site 444178002601 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 444178002602 FOG: WD40 repeat [General function prediction only]; Region: COG2319 444178002603 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 444178002604 structural tetrad; other site 444178002605 Predicted esterase [General function prediction only]; Region: COG0400 444178002606 putative hydrolase; Provisional; Region: PRK11460 444178002607 TMAO/DMSO reductase; Reviewed; Region: PRK05363 444178002608 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 444178002609 Moco binding site; other site 444178002610 metal coordination site [ion binding]; other site 444178002611 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 444178002612 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 444178002613 homotrimer interaction site [polypeptide binding]; other site 444178002614 putative active site [active] 444178002615 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 444178002616 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 444178002617 TM-ABC transporter signature motif; other site 444178002618 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 444178002619 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 444178002620 putative ligand binding site [chemical binding]; other site 444178002621 Transcriptional regulator [Transcription]; Region: IclR; COG1414 444178002622 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 444178002623 putative DNA binding site [nucleotide binding]; other site 444178002624 putative Zn2+ binding site [ion binding]; other site 444178002625 Bacterial transcriptional regulator; Region: IclR; pfam01614 444178002626 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 444178002627 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 444178002628 N-terminal plug; other site 444178002629 ligand-binding site [chemical binding]; other site 444178002630 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 444178002631 dimer interface [polypeptide binding]; other site 444178002632 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 444178002633 metal binding site [ion binding]; metal-binding site 444178002634 glutathionine S-transferase; Provisional; Region: PRK10542 444178002635 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 444178002636 C-terminal domain interface [polypeptide binding]; other site 444178002637 GSH binding site (G-site) [chemical binding]; other site 444178002638 dimer interface [polypeptide binding]; other site 444178002639 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 444178002640 dimer interface [polypeptide binding]; other site 444178002641 N-terminal domain interface [polypeptide binding]; other site 444178002642 substrate binding pocket (H-site) [chemical binding]; other site 444178002643 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 444178002644 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 444178002645 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 444178002646 metal binding site [ion binding]; metal-binding site 444178002647 active site 444178002648 I-site; other site 444178002649 Predicted dehydrogenase [General function prediction only]; Region: COG0579 444178002650 hydroxyglutarate oxidase; Provisional; Region: PRK11728 444178002651 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 444178002652 DNA polymerase III subunit epsilon; Validated; Region: PRK09182 444178002653 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 444178002654 active site 444178002655 catalytic site [active] 444178002656 substrate binding site [chemical binding]; other site 444178002657 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 444178002658 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 444178002659 Walker A/P-loop; other site 444178002660 ATP binding site [chemical binding]; other site 444178002661 Q-loop/lid; other site 444178002662 ABC transporter signature motif; other site 444178002663 Walker B; other site 444178002664 D-loop; other site 444178002665 H-loop/switch region; other site 444178002666 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 444178002667 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 444178002668 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 444178002669 Walker A/P-loop; other site 444178002670 ATP binding site [chemical binding]; other site 444178002671 Q-loop/lid; other site 444178002672 ABC transporter signature motif; other site 444178002673 Walker B; other site 444178002674 D-loop; other site 444178002675 H-loop/switch region; other site 444178002676 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 444178002677 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 444178002678 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178002679 dimer interface [polypeptide binding]; other site 444178002680 conserved gate region; other site 444178002681 putative PBP binding loops; other site 444178002682 ABC-ATPase subunit interface; other site 444178002683 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 444178002684 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178002685 dimer interface [polypeptide binding]; other site 444178002686 conserved gate region; other site 444178002687 putative PBP binding loops; other site 444178002688 ABC-ATPase subunit interface; other site 444178002689 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 444178002690 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 444178002691 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345 444178002692 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 444178002693 putative NAD(P) binding site [chemical binding]; other site 444178002694 active site 444178002695 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 444178002696 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 444178002697 NAD(P) binding site [chemical binding]; other site 444178002698 catalytic residues [active] 444178002699 catalytic residues [active] 444178002700 Transcriptional regulators [Transcription]; Region: GntR; COG1802 444178002701 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 444178002702 DNA-binding site [nucleotide binding]; DNA binding site 444178002703 FCD domain; Region: FCD; pfam07729 444178002704 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 444178002705 Major Facilitator Superfamily; Region: MFS_1; pfam07690 444178002706 putative substrate translocation pore; other site 444178002707 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 444178002708 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 444178002709 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 444178002710 homotrimer interaction site [polypeptide binding]; other site 444178002711 putative active site [active] 444178002712 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 444178002713 ribonuclease P; Reviewed; Region: rnpA; PRK01313 444178002714 membrane protein insertase; Provisional; Region: PRK01318 444178002715 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 444178002716 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 444178002717 G1 box; other site 444178002718 GTP/Mg2+ binding site [chemical binding]; other site 444178002719 Switch I region; other site 444178002720 G2 box; other site 444178002721 G3 box; other site 444178002722 Switch II region; other site 444178002723 G4 box; other site 444178002724 G5 box; other site 444178002725 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 444178002726 homohexameric interface [polypeptide binding]; other site 444178002727 feedback inhibition sensing region; other site 444178002728 nucleotide binding site [chemical binding]; other site 444178002729 N-acetyl-L-glutamate binding site [chemical binding]; other site 444178002730 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 444178002731 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 444178002732 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 444178002733 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 444178002734 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 444178002735 trimer interface [polypeptide binding]; other site 444178002736 active site 444178002737 substrate binding site [chemical binding]; other site 444178002738 CoA binding site [chemical binding]; other site 444178002739 Predicted transglutaminase-like cysteine proteinase [General function prediction only]; Region: COG3672 444178002740 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 444178002741 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 444178002742 metal binding site [ion binding]; metal-binding site 444178002743 dimer interface [polypeptide binding]; other site 444178002744 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 444178002745 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 444178002746 dimerization interface 3.5A [polypeptide binding]; other site 444178002747 active site 444178002748 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 444178002749 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 444178002750 putative active site [active] 444178002751 substrate binding site [chemical binding]; other site 444178002752 putative cosubstrate binding site; other site 444178002753 catalytic site [active] 444178002754 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 444178002755 substrate binding site [chemical binding]; other site 444178002756 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 444178002757 active site 444178002758 catalytic residues [active] 444178002759 metal binding site [ion binding]; metal-binding site 444178002760 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 444178002761 RmuC family; Region: RmuC; pfam02646 444178002762 Uncharacterized protein conserved in bacteria [Posttranslational modification, protein turnover, chaperones]; Region: COG3526 444178002763 GTP-binding protein LepA; Provisional; Region: PRK05433 444178002764 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 444178002765 G1 box; other site 444178002766 putative GEF interaction site [polypeptide binding]; other site 444178002767 GTP/Mg2+ binding site [chemical binding]; other site 444178002768 Switch I region; other site 444178002769 G2 box; other site 444178002770 G3 box; other site 444178002771 Switch II region; other site 444178002772 G4 box; other site 444178002773 G5 box; other site 444178002774 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 444178002775 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 444178002776 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 444178002777 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 444178002778 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 444178002779 putative NAD(P) binding site [chemical binding]; other site 444178002780 active site 444178002781 Undecaprenyl pyrophosphate phosphatase [Lipid transport and metabolism]; Region: BacA; COG1968 444178002782 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 444178002783 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 444178002784 C-terminal domain interface [polypeptide binding]; other site 444178002785 GSH binding site (G-site) [chemical binding]; other site 444178002786 dimer interface [polypeptide binding]; other site 444178002787 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 444178002788 N-terminal domain interface [polypeptide binding]; other site 444178002789 dimer interface [polypeptide binding]; other site 444178002790 substrate binding pocket (H-site) [chemical binding]; other site 444178002791 epoxyqueuosine reductase; Region: TIGR00276 444178002792 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 444178002793 HEAT repeat; Region: HEAT; pfam02985 444178002794 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 444178002795 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 444178002796 putative NAD(P) binding site [chemical binding]; other site 444178002797 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 444178002798 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 444178002799 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 444178002800 active site 444178002801 dimer interfaces [polypeptide binding]; other site 444178002802 catalytic residues [active] 444178002803 Glucokinase [Carbohydrate transport and metabolism]; Region: Glk; COG0837 444178002804 glucokinase, proteobacterial type; Region: glk; TIGR00749 444178002805 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 444178002806 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 444178002807 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 444178002808 Walker A/P-loop; other site 444178002809 ATP binding site [chemical binding]; other site 444178002810 Q-loop/lid; other site 444178002811 ABC transporter signature motif; other site 444178002812 Walker B; other site 444178002813 D-loop; other site 444178002814 H-loop/switch region; other site 444178002815 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 444178002816 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 444178002817 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 444178002818 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 444178002819 catalytic core [active] 444178002820 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 444178002821 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 444178002822 active site 444178002823 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 444178002824 putative FMN binding site [chemical binding]; other site 444178002825 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 444178002826 Ligand Binding Site [chemical binding]; other site 444178002827 Predicted membrane protein [Function unknown]; Region: COG3714 444178002828 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 444178002829 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 444178002830 NAD(P) binding site [chemical binding]; other site 444178002831 catalytic residues [active] 444178002832 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 444178002833 putative catalytic site [active] 444178002834 putative metal binding site [ion binding]; other site 444178002835 putative phosphate binding site [ion binding]; other site 444178002836 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 444178002837 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 444178002838 putative active site [active] 444178002839 catalytic site [active] 444178002840 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 444178002841 putative active site [active] 444178002842 catalytic site [active] 444178002843 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 444178002844 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 444178002845 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 444178002846 G1 box; other site 444178002847 putative GEF interaction site [polypeptide binding]; other site 444178002848 GTP/Mg2+ binding site [chemical binding]; other site 444178002849 Switch I region; other site 444178002850 G2 box; other site 444178002851 G3 box; other site 444178002852 Switch II region; other site 444178002853 G4 box; other site 444178002854 G5 box; other site 444178002855 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 444178002856 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 444178002857 Flavoprotein; Region: Flavoprotein; pfam02441 444178002858 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 444178002859 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 444178002860 ABC1 family; Region: ABC1; pfam03109 444178002861 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 444178002862 active site 444178002863 ATP binding site [chemical binding]; other site 444178002864 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 444178002865 substrate binding site [chemical binding]; other site 444178002866 activation loop (A-loop); other site 444178002867 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 444178002868 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 444178002869 S-adenosylmethionine binding site [chemical binding]; other site 444178002870 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 444178002871 active site 444178002872 hypothetical protein; Provisional; Region: PRK00736 444178002873 methionine sulfoxide reductase A; Provisional; Region: PRK00058 444178002874 putative transposase OrfB; Reviewed; Region: PHA02517 444178002875 HTH-like domain; Region: HTH_21; pfam13276 444178002876 Integrase core domain; Region: rve; pfam00665 444178002877 Integrase core domain; Region: rve_3; pfam13683 444178002878 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 444178002879 Transposase; Region: HTH_Tnp_1; pfam01527 444178002880 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 444178002881 Transposase; Region: HTH_Tnp_1; pfam01527 444178002882 putative transposase OrfB; Reviewed; Region: PHA02517 444178002883 HTH-like domain; Region: HTH_21; pfam13276 444178002884 Integrase core domain; Region: rve; pfam00665 444178002885 Integrase core domain; Region: rve_3; pfam13683 444178002886 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 444178002887 Rrf2 family protein; Region: rrf2_super; TIGR00738 444178002888 Transcriptional regulator; Region: Rrf2; pfam02082 444178002889 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 444178002890 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 444178002891 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 444178002892 ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531 444178002893 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 444178002894 metal binding site [ion binding]; metal-binding site 444178002895 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 444178002896 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 444178002897 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 444178002898 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 444178002899 ABC-ATPase subunit interface; other site 444178002900 dimer interface [polypeptide binding]; other site 444178002901 putative PBP binding regions; other site 444178002902 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 444178002903 metal binding site 2 [ion binding]; metal-binding site 444178002904 putative DNA binding helix; other site 444178002905 metal binding site 1 [ion binding]; metal-binding site 444178002906 dimer interface [polypeptide binding]; other site 444178002907 structural Zn2+ binding site [ion binding]; other site 444178002908 Rod binding protein; Region: Rod-binding; pfam10135 444178002909 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 444178002910 flagellar biosynthesis protein FlhA; Reviewed; Region: flhA; PRK12792 444178002911 FHIPEP family; Region: FHIPEP; pfam00771 444178002912 flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010 444178002913 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009 444178002914 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 444178002915 Flagellar biosynthesis regulator FlbT [Cell motility and secretion]; Region: FlbT; COG5443 444178002916 Flagellar biosynthesis regulator FlaF [Cell motility and secretion]; Region: FlaF; COG5442 444178002917 flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793 444178002918 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008 444178002919 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 444178002920 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 444178002921 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 444178002922 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 444178002923 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 444178002924 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 444178002925 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 444178002926 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 444178002927 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 444178002928 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 444178002929 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 444178002930 DNA binding site [nucleotide binding] 444178002931 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 444178002932 chemotaxis protein; Reviewed; Region: PRK12798 444178002933 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 444178002934 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 444178002935 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 444178002936 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 444178002937 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 444178002938 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 444178002939 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 444178002940 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 444178002941 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 444178002942 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 444178002943 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 444178002944 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 444178002945 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 444178002946 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 444178002947 Autotransporter beta-domain; Region: Autotransporter; pfam03797 444178002948 Uncharacterized conserved protein [Function unknown]; Region: COG3268 444178002949 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 444178002950 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 444178002951 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 444178002952 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 444178002953 TM-ABC transporter signature motif; other site 444178002954 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 444178002955 HTH domain; Region: HTH_11; cl17392 444178002956 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 444178002957 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Region: HpaI; TIGR02311 444178002958 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 444178002959 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 444178002960 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 444178002961 NAD binding site [chemical binding]; other site 444178002962 catalytic residues [active] 444178002963 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 444178002964 putative substrate binding pocket [chemical binding]; other site 444178002965 trimer interface [polypeptide binding]; other site 444178002966 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 444178002967 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 444178002968 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 444178002969 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 444178002970 active site 444178002971 ATP binding site [chemical binding]; other site 444178002972 substrate binding site [chemical binding]; other site 444178002973 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 444178002974 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 444178002975 Uncharacterized conserved protein [Function unknown]; Region: COG5441; cl02262 444178002976 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 444178002977 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 444178002978 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 444178002979 NAD(P) binding site [chemical binding]; other site 444178002980 catalytic residues [active] 444178002981 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 444178002982 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 444178002983 active site 444178002984 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 444178002985 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 444178002986 putative ligand binding site [chemical binding]; other site 444178002987 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 444178002988 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 444178002989 TM-ABC transporter signature motif; other site 444178002990 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 444178002991 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 444178002992 Walker A/P-loop; other site 444178002993 ATP binding site [chemical binding]; other site 444178002994 Q-loop/lid; other site 444178002995 ABC transporter signature motif; other site 444178002996 Walker B; other site 444178002997 D-loop; other site 444178002998 H-loop/switch region; other site 444178002999 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 444178003000 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 444178003001 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 444178003002 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178003003 dimer interface [polypeptide binding]; other site 444178003004 conserved gate region; other site 444178003005 putative PBP binding loops; other site 444178003006 ABC-ATPase subunit interface; other site 444178003007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178003008 dimer interface [polypeptide binding]; other site 444178003009 conserved gate region; other site 444178003010 putative PBP binding loops; other site 444178003011 ABC-ATPase subunit interface; other site 444178003012 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 444178003013 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 444178003014 Walker A/P-loop; other site 444178003015 ATP binding site [chemical binding]; other site 444178003016 Q-loop/lid; other site 444178003017 ABC transporter signature motif; other site 444178003018 Walker B; other site 444178003019 D-loop; other site 444178003020 H-loop/switch region; other site 444178003021 TOBE domain; Region: TOBE_2; pfam08402 444178003022 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 444178003023 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 444178003024 active site 444178003025 metal binding site [ion binding]; metal-binding site 444178003026 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 444178003027 Sulfatase; Region: Sulfatase; cl17466 444178003028 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 444178003029 NMT1-like family; Region: NMT1_2; pfam13379 444178003030 substrate binding pocket [chemical binding]; other site 444178003031 membrane-bound complex binding site; other site 444178003032 hinge residues; other site 444178003033 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 444178003034 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 444178003035 Walker A/P-loop; other site 444178003036 ATP binding site [chemical binding]; other site 444178003037 Q-loop/lid; other site 444178003038 ABC transporter signature motif; other site 444178003039 Walker B; other site 444178003040 D-loop; other site 444178003041 H-loop/switch region; other site 444178003042 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 444178003043 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 444178003044 nucleotide binding site [chemical binding]; other site 444178003045 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 444178003046 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 444178003047 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 444178003048 N-terminal plug; other site 444178003049 ligand-binding site [chemical binding]; other site 444178003050 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 444178003051 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 444178003052 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 444178003053 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_5; cd06338 444178003054 putative ligand binding site [chemical binding]; other site 444178003055 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 444178003056 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 444178003057 TM-ABC transporter signature motif; other site 444178003058 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 444178003059 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 444178003060 TM-ABC transporter signature motif; other site 444178003061 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 444178003062 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 444178003063 Walker A/P-loop; other site 444178003064 ATP binding site [chemical binding]; other site 444178003065 Q-loop/lid; other site 444178003066 ABC transporter signature motif; other site 444178003067 Walker B; other site 444178003068 D-loop; other site 444178003069 H-loop/switch region; other site 444178003070 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 444178003071 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 444178003072 Walker A/P-loop; other site 444178003073 ATP binding site [chemical binding]; other site 444178003074 Q-loop/lid; other site 444178003075 ABC transporter signature motif; other site 444178003076 Walker B; other site 444178003077 D-loop; other site 444178003078 H-loop/switch region; other site 444178003079 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 444178003080 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 444178003081 Soluble P-type ATPase [General function prediction only]; Region: COG4087 444178003082 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 444178003083 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 444178003084 FeS/SAM binding site; other site 444178003085 HemN C-terminal domain; Region: HemN_C; pfam06969 444178003086 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 444178003087 MerR family regulatory protein; Region: MerR; pfam00376 444178003088 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 444178003089 P-loop; other site 444178003090 Magnesium ion binding site [ion binding]; other site 444178003091 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 444178003092 P-loop; other site 444178003093 Magnesium ion binding site [ion binding]; other site 444178003094 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 444178003095 ParB-like nuclease domain; Region: ParB; smart00470 444178003096 DnaA N-terminal domain; Region: DnaA_N; pfam11638 444178003097 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 444178003098 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 444178003099 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 444178003100 DnaA box-binding interface [nucleotide binding]; other site 444178003101 DNA polymerase III subunit beta; Validated; Region: PRK05643 444178003102 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 444178003103 putative DNA binding surface [nucleotide binding]; other site 444178003104 dimer interface [polypeptide binding]; other site 444178003105 beta-clamp/clamp loader binding surface; other site 444178003106 beta-clamp/translesion DNA polymerase binding surface; other site 444178003107 recombination protein F; Reviewed; Region: recF; PRK00064 444178003108 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 444178003109 Walker A/P-loop; other site 444178003110 ATP binding site [chemical binding]; other site 444178003111 Q-loop/lid; other site 444178003112 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 444178003113 ABC transporter signature motif; other site 444178003114 Walker B; other site 444178003115 D-loop; other site 444178003116 H-loop/switch region; other site 444178003117 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 444178003118 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 444178003119 ATP binding site [chemical binding]; other site 444178003120 substrate interface [chemical binding]; other site 444178003121 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 444178003122 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 444178003123 putative ligand binding site [chemical binding]; other site 444178003124 NAD binding site [chemical binding]; other site 444178003125 dimerization interface [polypeptide binding]; other site 444178003126 catalytic site [active] 444178003127 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 444178003128 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 444178003129 Walker A/P-loop; other site 444178003130 ATP binding site [chemical binding]; other site 444178003131 Q-loop/lid; other site 444178003132 ABC transporter signature motif; other site 444178003133 Walker B; other site 444178003134 D-loop; other site 444178003135 H-loop/switch region; other site 444178003136 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 444178003137 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 444178003138 Walker A/P-loop; other site 444178003139 ATP binding site [chemical binding]; other site 444178003140 Q-loop/lid; other site 444178003141 ABC transporter signature motif; other site 444178003142 Walker B; other site 444178003143 D-loop; other site 444178003144 H-loop/switch region; other site 444178003145 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 444178003146 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 444178003147 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178003148 dimer interface [polypeptide binding]; other site 444178003149 conserved gate region; other site 444178003150 putative PBP binding loops; other site 444178003151 ABC-ATPase subunit interface; other site 444178003152 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 444178003153 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178003154 dimer interface [polypeptide binding]; other site 444178003155 conserved gate region; other site 444178003156 putative PBP binding loops; other site 444178003157 ABC-ATPase subunit interface; other site 444178003158 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 444178003159 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 444178003160 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 444178003161 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 444178003162 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 444178003163 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 444178003164 dimerization interface [polypeptide binding]; other site 444178003165 ligand binding site [chemical binding]; other site 444178003166 enoyl-CoA hydratase; Provisional; Region: PRK07468 444178003167 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 444178003168 substrate binding site [chemical binding]; other site 444178003169 oxyanion hole (OAH) forming residues; other site 444178003170 trimer interface [polypeptide binding]; other site 444178003171 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 444178003172 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 444178003173 active site 444178003174 catalytic residues [active] 444178003175 metal binding site [ion binding]; metal-binding site 444178003176 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 444178003177 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 444178003178 ATP-grasp domain; Region: ATP-grasp_4; cl17255 444178003179 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 444178003180 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 444178003181 carboxyltransferase (CT) interaction site; other site 444178003182 biotinylation site [posttranslational modification]; other site 444178003183 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 444178003184 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 444178003185 isovaleryl-CoA dehydrogenase; Region: PLN02519 444178003186 substrate binding site [chemical binding]; other site 444178003187 FAD binding site [chemical binding]; other site 444178003188 catalytic base [active] 444178003189 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 444178003190 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 444178003191 acyl-activating enzyme (AAE) consensus motif; other site 444178003192 putative AMP binding site [chemical binding]; other site 444178003193 putative active site [active] 444178003194 putative CoA binding site [chemical binding]; other site 444178003195 CHRD domain; Region: CHRD; pfam07452 444178003196 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 444178003197 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4530 444178003198 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 444178003199 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 444178003200 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 444178003201 hinge; other site 444178003202 active site 444178003203 cytidylate kinase; Provisional; Region: cmk; PRK00023 444178003204 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 444178003205 CMP-binding site; other site 444178003206 The sites determining sugar specificity; other site 444178003207 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 444178003208 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 444178003209 RNA binding site [nucleotide binding]; other site 444178003210 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 444178003211 RNA binding site [nucleotide binding]; other site 444178003212 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 444178003213 RNA binding site [nucleotide binding]; other site 444178003214 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 444178003215 RNA binding site [nucleotide binding]; other site 444178003216 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 444178003217 RNA binding site [nucleotide binding]; other site 444178003218 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 444178003219 RNA binding site [nucleotide binding]; other site 444178003220 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 444178003221 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 444178003222 Predicted membrane protein [Function unknown]; Region: COG2855 444178003223 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 444178003224 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 444178003225 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 444178003226 putative dimerization interface [polypeptide binding]; other site 444178003227 lytic murein transglycosylase; Region: MltB_2; TIGR02283 444178003228 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 444178003229 N-acetyl-D-glucosamine binding site [chemical binding]; other site 444178003230 recombination protein RecR; Reviewed; Region: recR; PRK00076 444178003231 RecR protein; Region: RecR; pfam02132 444178003232 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 444178003233 putative active site [active] 444178003234 putative metal-binding site [ion binding]; other site 444178003235 tetramer interface [polypeptide binding]; other site 444178003236 hypothetical protein; Validated; Region: PRK00153 444178003237 DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111 444178003238 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 444178003239 Walker A motif; other site 444178003240 ATP binding site [chemical binding]; other site 444178003241 Walker B motif; other site 444178003242 arginine finger; other site 444178003243 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 444178003244 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 444178003245 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 444178003246 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 444178003247 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 444178003248 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 444178003249 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 444178003250 putative NADH binding site [chemical binding]; other site 444178003251 putative active site [active] 444178003252 nudix motif; other site 444178003253 putative metal binding site [ion binding]; other site 444178003254 prephenate dehydratase; Provisional; Region: PRK11899 444178003255 Prephenate dehydratase; Region: PDT; pfam00800 444178003256 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 444178003257 putative L-Phe binding site [chemical binding]; other site 444178003258 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 444178003259 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 444178003260 Ligand binding site; other site 444178003261 oligomer interface; other site 444178003262 Cytochrome c2 [Energy production and conversion]; Region: COG3474 444178003263 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 444178003264 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 444178003265 putative MPT binding site; other site 444178003266 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 444178003267 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 444178003268 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 444178003269 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 444178003270 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 444178003271 D-pathway; other site 444178003272 Putative ubiquinol binding site [chemical binding]; other site 444178003273 Low-spin heme (heme b) binding site [chemical binding]; other site 444178003274 Putative water exit pathway; other site 444178003275 Binuclear center (heme o3/CuB) [ion binding]; other site 444178003276 K-pathway; other site 444178003277 Putative proton exit pathway; other site 444178003278 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 444178003279 Subunit I/III interface [polypeptide binding]; other site 444178003280 Subunit III/IV interface [polypeptide binding]; other site 444178003281 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 444178003282 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 444178003283 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 444178003284 Surface antigen; Region: Bac_surface_Ag; pfam01103 444178003285 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 444178003286 Family of unknown function (DUF490); Region: DUF490; pfam04357 444178003287 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 444178003288 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 444178003289 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 444178003290 Copper(I)-binding protein [Inorganic ion transport and metabolism]; Region: COG2847 444178003291 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 444178003292 dimer interface [polypeptide binding]; other site 444178003293 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 444178003294 active site 444178003295 metal binding site [ion binding]; metal-binding site 444178003296 glutathione binding site [chemical binding]; other site 444178003297 Domain of unknown function DUF59; Region: DUF59; pfam01883 444178003298 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 444178003299 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 444178003300 Walker A motif; other site 444178003301 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 444178003302 phosphoglucomutase; Region: PLN02307 444178003303 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 444178003304 substrate binding site [chemical binding]; other site 444178003305 dimer interface [polypeptide binding]; other site 444178003306 active site 444178003307 metal binding site [ion binding]; metal-binding site 444178003308 Transcriptional regulator [Transcription]; Region: LysR; COG0583 444178003309 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 444178003310 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 444178003311 putative effector binding pocket; other site 444178003312 putative dimerization interface [polypeptide binding]; other site 444178003313 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 444178003314 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 444178003315 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 444178003316 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 444178003317 active site 444178003318 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 444178003319 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 444178003320 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 444178003321 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 444178003322 N-acetyl-D-glucosamine binding site [chemical binding]; other site 444178003323 catalytic residue [active] 444178003324 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 444178003325 Haemagglutinin; Region: HIM; pfam05662 444178003326 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 444178003327 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 444178003328 trimer interface [polypeptide binding]; other site 444178003329 Haemagglutinin; Region: HIM; pfam05662 444178003330 YadA-like C-terminal region; Region: YadA; pfam03895 444178003331 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 444178003332 argininosuccinate synthase; Provisional; Region: PRK13820 444178003333 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 444178003334 ANP binding site [chemical binding]; other site 444178003335 Substrate Binding Site II [chemical binding]; other site 444178003336 Substrate Binding Site I [chemical binding]; other site 444178003337 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 444178003338 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 444178003339 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 444178003340 FeS/SAM binding site; other site 444178003341 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 444178003342 Uncharacterized conserved protein [Function unknown]; Region: COG3339 444178003343 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 444178003344 aromatic arch; other site 444178003345 DCoH dimer interaction site [polypeptide binding]; other site 444178003346 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 444178003347 DCoH tetramer interaction site [polypeptide binding]; other site 444178003348 substrate binding site [chemical binding]; other site 444178003349 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 444178003350 Low molecular weight phosphatase family; Region: LMWPc; cd00115 444178003351 active site 444178003352 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 444178003353 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 444178003354 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 444178003355 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 444178003356 active site 444178003357 catalytic triad [active] 444178003358 oxyanion hole [active] 444178003359 switch loop; other site 444178003360 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 444178003361 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 444178003362 Walker A/P-loop; other site 444178003363 ATP binding site [chemical binding]; other site 444178003364 Q-loop/lid; other site 444178003365 ABC transporter signature motif; other site 444178003366 Walker B; other site 444178003367 D-loop; other site 444178003368 H-loop/switch region; other site 444178003369 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 444178003370 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 444178003371 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 444178003372 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 444178003373 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 444178003374 Coenzyme A binding pocket [chemical binding]; other site 444178003375 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 444178003376 Uncharacterized secreted protein [Function unknown]; Region: COG5429 444178003377 aconitate hydratase; Validated; Region: PRK09277 444178003378 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 444178003379 substrate binding site [chemical binding]; other site 444178003380 ligand binding site [chemical binding]; other site 444178003381 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 444178003382 substrate binding site [chemical binding]; other site 444178003383 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 444178003384 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 444178003385 Walker A/P-loop; other site 444178003386 ATP binding site [chemical binding]; other site 444178003387 Q-loop/lid; other site 444178003388 ABC transporter signature motif; other site 444178003389 Walker B; other site 444178003390 D-loop; other site 444178003391 H-loop/switch region; other site 444178003392 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmB; COG2386 444178003393 heme exporter protein CcmC; Region: ccmC; TIGR01191 444178003394 heme exporter protein CcmD; Region: cytochro_ccmD; TIGR03141 444178003395 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 444178003396 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 444178003397 catalytic residues [active] 444178003398 central insert; other site 444178003399 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 444178003400 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 444178003401 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 444178003402 active site 444178003403 phosphorylation site [posttranslational modification] 444178003404 intermolecular recognition site; other site 444178003405 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 444178003406 AsnC family; Region: AsnC_trans_reg; pfam01037 444178003407 Domain of Unknown Function (DUF930); Region: DUF930; pfam06059 444178003408 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604 444178003409 Uncharacterized conserved protein [Function unknown]; Region: COG1434 444178003410 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 444178003411 putative active site [active] 444178003412 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 444178003413 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 444178003414 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 444178003415 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 444178003416 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178003417 dimer interface [polypeptide binding]; other site 444178003418 conserved gate region; other site 444178003419 putative PBP binding loops; other site 444178003420 ABC-ATPase subunit interface; other site 444178003421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178003422 dimer interface [polypeptide binding]; other site 444178003423 conserved gate region; other site 444178003424 putative PBP binding loops; other site 444178003425 ABC-ATPase subunit interface; other site 444178003426 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 444178003427 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 444178003428 Walker A/P-loop; other site 444178003429 ATP binding site [chemical binding]; other site 444178003430 Q-loop/lid; other site 444178003431 ABC transporter signature motif; other site 444178003432 Walker B; other site 444178003433 D-loop; other site 444178003434 H-loop/switch region; other site 444178003435 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 444178003436 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 444178003437 Putative glucoamylase; Region: Glycoamylase; pfam10091 444178003438 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 444178003439 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 444178003440 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 444178003441 Protein of unknown function, DUF608; Region: DUF608; pfam04685 444178003442 Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488 444178003443 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 444178003444 active site 444178003445 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 444178003446 S-adenosylmethionine binding site [chemical binding]; other site 444178003447 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 444178003448 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 444178003449 putative substrate binding site [chemical binding]; other site 444178003450 putative ATP binding site [chemical binding]; other site 444178003451 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 444178003452 classical (c) SDRs; Region: SDR_c; cd05233 444178003453 NAD(P) binding site [chemical binding]; other site 444178003454 active site 444178003455 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 444178003456 Transglycosylase; Region: Transgly; pfam00912 444178003457 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 444178003458 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 444178003459 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 444178003460 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 444178003461 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 444178003462 catalytic site [active] 444178003463 putative active site [active] 444178003464 putative substrate binding site [chemical binding]; other site 444178003465 hypothetical protein; Validated; Region: PRK09104 444178003466 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 444178003467 metal binding site [ion binding]; metal-binding site 444178003468 putative dimer interface [polypeptide binding]; other site 444178003469 DNA polymerase I; Region: pola; TIGR00593 444178003470 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 444178003471 active site 444178003472 metal binding site 1 [ion binding]; metal-binding site 444178003473 putative 5' ssDNA interaction site; other site 444178003474 metal binding site 3; metal-binding site 444178003475 metal binding site 2 [ion binding]; metal-binding site 444178003476 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 444178003477 putative DNA binding site [nucleotide binding]; other site 444178003478 putative metal binding site [ion binding]; other site 444178003479 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 444178003480 active site 444178003481 catalytic site [active] 444178003482 substrate binding site [chemical binding]; other site 444178003483 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 444178003484 active site 444178003485 DNA binding site [nucleotide binding] 444178003486 catalytic site [active] 444178003487 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 444178003488 DEAD-like helicases superfamily; Region: DEXDc; smart00487 444178003489 ATP binding site [chemical binding]; other site 444178003490 Mg++ binding site [ion binding]; other site 444178003491 motif III; other site 444178003492 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 444178003493 nucleotide binding region [chemical binding]; other site 444178003494 ATP-binding site [chemical binding]; other site 444178003495 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 444178003496 RNA binding site [nucleotide binding]; other site 444178003497 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 444178003498 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 444178003499 Mg2+ binding site [ion binding]; other site 444178003500 G-X-G motif; other site 444178003501 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 444178003502 anchoring element; other site 444178003503 dimer interface [polypeptide binding]; other site 444178003504 ATP binding site [chemical binding]; other site 444178003505 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 444178003506 active site 444178003507 putative metal-binding site [ion binding]; other site 444178003508 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 444178003509 S-formylglutathione hydrolase; Region: PLN02442 444178003510 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 444178003511 Predicted membrane protein [Function unknown]; Region: COG4291 444178003512 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 444178003513 putative metal binding site [ion binding]; other site 444178003514 putative homodimer interface [polypeptide binding]; other site 444178003515 putative homotetramer interface [polypeptide binding]; other site 444178003516 putative homodimer-homodimer interface [polypeptide binding]; other site 444178003517 putative allosteric switch controlling residues; other site 444178003518 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 444178003519 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 444178003520 ATP binding site [chemical binding]; other site 444178003521 putative Mg++ binding site [ion binding]; other site 444178003522 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 444178003523 nucleotide binding region [chemical binding]; other site 444178003524 ATP-binding site [chemical binding]; other site 444178003525 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 444178003526 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 444178003527 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 444178003528 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 444178003529 ATP binding site [chemical binding]; other site 444178003530 Mg2+ binding site [ion binding]; other site 444178003531 G-X-G motif; other site 444178003532 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 444178003533 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 444178003534 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 444178003535 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 444178003536 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 444178003537 active site 444178003538 phosphorylation site [posttranslational modification] 444178003539 intermolecular recognition site; other site 444178003540 dimerization interface [polypeptide binding]; other site 444178003541 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 444178003542 Protein of unknown function (DUF1052); Region: DUF1052; pfam06319 444178003543 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 444178003544 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 444178003545 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 444178003546 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 444178003547 Universal stress protein family; Region: Usp; pfam00582 444178003548 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 444178003549 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 444178003550 active site 444178003551 HIGH motif; other site 444178003552 dimer interface [polypeptide binding]; other site 444178003553 KMSKS motif; other site 444178003554 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 444178003555 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 444178003556 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 444178003557 PII uridylyl-transferase; Provisional; Region: PRK05092 444178003558 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 444178003559 metal binding triad; other site 444178003560 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 444178003561 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 444178003562 Zn2+ binding site [ion binding]; other site 444178003563 Mg2+ binding site [ion binding]; other site 444178003564 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 444178003565 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 444178003566 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 444178003567 MutS domain I; Region: MutS_I; pfam01624 444178003568 MutS domain II; Region: MutS_II; pfam05188 444178003569 MutS domain III; Region: MutS_III; pfam05192 444178003570 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 444178003571 Walker A/P-loop; other site 444178003572 ATP binding site [chemical binding]; other site 444178003573 Q-loop/lid; other site 444178003574 ABC transporter signature motif; other site 444178003575 Walker B; other site 444178003576 D-loop; other site 444178003577 H-loop/switch region; other site 444178003578 Putative hemolysin [General function prediction only]; Region: COG3176 444178003579 lipoprotein signal peptidase; Provisional; Region: PRK14795 444178003580 lipoprotein signal peptidase; Provisional; Region: PRK14787 444178003581 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 444178003582 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 444178003583 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 444178003584 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 444178003585 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 444178003586 S-adenosylmethionine binding site [chemical binding]; other site 444178003587 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 444178003588 IHF dimer interface [polypeptide binding]; other site 444178003589 IHF - DNA interface [nucleotide binding]; other site 444178003590 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 444178003591 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 444178003592 tandem repeat interface [polypeptide binding]; other site 444178003593 oligomer interface [polypeptide binding]; other site 444178003594 active site residues [active] 444178003595 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 444178003596 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 444178003597 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 444178003598 OstA-like protein; Region: OstA; pfam03968 444178003599 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 444178003600 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 444178003601 Walker A/P-loop; other site 444178003602 ATP binding site [chemical binding]; other site 444178003603 Q-loop/lid; other site 444178003604 ABC transporter signature motif; other site 444178003605 Walker B; other site 444178003606 D-loop; other site 444178003607 H-loop/switch region; other site 444178003608 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 444178003609 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 444178003610 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 444178003611 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 444178003612 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 444178003613 30S subunit binding site; other site 444178003614 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 444178003615 active site 444178003616 phosphorylation site [posttranslational modification] 444178003617 Uncharacterized small protein [Function unknown]; Region: COG5568 444178003618 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 444178003619 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 444178003620 putative dimer interface [polypeptide binding]; other site 444178003621 Integral membrane protein [Function unknown]; Region: COG5488 444178003622 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 444178003623 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 444178003624 minor groove reading motif; other site 444178003625 helix-hairpin-helix signature motif; other site 444178003626 substrate binding pocket [chemical binding]; other site 444178003627 active site 444178003628 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 444178003629 CysZ-like protein; Reviewed; Region: PRK12768 444178003630 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 444178003631 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 444178003632 substrate binding site [chemical binding]; other site 444178003633 ATP binding site [chemical binding]; other site 444178003634 Predicted membrane protein [Function unknown]; Region: COG2860 444178003635 UPF0126 domain; Region: UPF0126; pfam03458 444178003636 UPF0126 domain; Region: UPF0126; pfam03458 444178003637 heat shock protein GrpE; Provisional; Region: PRK14141 444178003638 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 444178003639 dimer interface [polypeptide binding]; other site 444178003640 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 444178003641 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 444178003642 ribonuclease PH; Reviewed; Region: rph; PRK00173 444178003643 Ribonuclease PH; Region: RNase_PH_bact; cd11362 444178003644 hexamer interface [polypeptide binding]; other site 444178003645 active site 444178003646 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 444178003647 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 444178003648 putative metal binding site [ion binding]; other site 444178003649 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 444178003650 active site 444178003651 dimerization interface [polypeptide binding]; other site 444178003652 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 444178003653 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 444178003654 FeS/SAM binding site; other site 444178003655 HemN C-terminal domain; Region: HemN_C; pfam06969 444178003656 Predicted methyltransferases [General function prediction only]; Region: COG0313 444178003657 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 444178003658 putative SAM binding site [chemical binding]; other site 444178003659 putative homodimer interface [polypeptide binding]; other site 444178003660 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 444178003661 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 444178003662 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 444178003663 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 444178003664 active site 444178003665 SAM binding site [chemical binding]; other site 444178003666 homodimer interface [polypeptide binding]; other site 444178003667 Protein of unknown function (DUF2849); Region: DUF2849; pfam11011 444178003668 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 444178003669 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 444178003670 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 444178003671 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 444178003672 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 444178003673 Active Sites [active] 444178003674 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3749 444178003675 Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876 444178003676 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 444178003677 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 444178003678 active site 444178003679 DNA binding site [nucleotide binding] 444178003680 BA14K-like protein; Region: BA14K; pfam07886 444178003681 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 444178003682 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 444178003683 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 444178003684 substrate binding pocket [chemical binding]; other site 444178003685 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 444178003686 B12 binding site [chemical binding]; other site 444178003687 cobalt ligand [ion binding]; other site 444178003688 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 444178003689 Autoinducer binding domain; Region: Autoind_bind; pfam03472 444178003690 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 444178003691 DNA binding residues [nucleotide binding] 444178003692 aminotransferase; Provisional; Region: PRK06105 444178003693 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 444178003694 inhibitor-cofactor binding pocket; inhibition site 444178003695 pyridoxal 5'-phosphate binding site [chemical binding]; other site 444178003696 catalytic residue [active] 444178003697 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 444178003698 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 444178003699 Active Sites [active] 444178003700 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 444178003701 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 444178003702 CysD dimerization site [polypeptide binding]; other site 444178003703 G1 box; other site 444178003704 putative GEF interaction site [polypeptide binding]; other site 444178003705 GTP/Mg2+ binding site [chemical binding]; other site 444178003706 Switch I region; other site 444178003707 G2 box; other site 444178003708 G3 box; other site 444178003709 Switch II region; other site 444178003710 G4 box; other site 444178003711 G5 box; other site 444178003712 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 444178003713 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 444178003714 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 444178003715 ligand-binding site [chemical binding]; other site 444178003716 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 444178003717 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 444178003718 active site 444178003719 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 444178003720 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 444178003721 ligand binding site [chemical binding]; other site 444178003722 flexible hinge region; other site 444178003723 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 444178003724 putative switch regulator; other site 444178003725 non-specific DNA interactions [nucleotide binding]; other site 444178003726 DNA binding site [nucleotide binding] 444178003727 sequence specific DNA binding site [nucleotide binding]; other site 444178003728 putative cAMP binding site [chemical binding]; other site 444178003729 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 444178003730 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 444178003731 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 444178003732 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 444178003733 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 444178003734 GAF domain; Region: GAF; pfam01590 444178003735 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 444178003736 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 444178003737 NAD(P) binding site [chemical binding]; other site 444178003738 catalytic residues [active] 444178003739 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 444178003740 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 444178003741 NAD binding site [chemical binding]; other site 444178003742 substrate binding site [chemical binding]; other site 444178003743 catalytic Zn binding site [ion binding]; other site 444178003744 tetramer interface [polypeptide binding]; other site 444178003745 structural Zn binding site [ion binding]; other site 444178003746 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3564 444178003747 Transcriptional regulators [Transcription]; Region: PurR; COG1609 444178003748 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 444178003749 DNA binding site [nucleotide binding] 444178003750 domain linker motif; other site 444178003751 Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545 444178003752 putative dimerization interface [polypeptide binding]; other site 444178003753 putative ligand binding site [chemical binding]; other site 444178003754 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 444178003755 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 444178003756 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 444178003757 Walker A/P-loop; other site 444178003758 ATP binding site [chemical binding]; other site 444178003759 Q-loop/lid; other site 444178003760 ABC transporter signature motif; other site 444178003761 Walker B; other site 444178003762 D-loop; other site 444178003763 H-loop/switch region; other site 444178003764 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 444178003765 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 444178003766 NAD(P) binding site [chemical binding]; other site 444178003767 catalytic residues [active] 444178003768 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 444178003769 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178003770 dimer interface [polypeptide binding]; other site 444178003771 conserved gate region; other site 444178003772 putative PBP binding loops; other site 444178003773 ABC-ATPase subunit interface; other site 444178003774 Putative transcription activator [Transcription]; Region: TenA; COG0819 444178003775 NMT1/THI5 like; Region: NMT1; pfam09084 444178003776 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 444178003777 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 444178003778 active site 444178003779 thiamine phosphate binding site [chemical binding]; other site 444178003780 pyrophosphate binding site [ion binding]; other site 444178003781 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 444178003782 ThiS interaction site; other site 444178003783 putative active site [active] 444178003784 tetramer interface [polypeptide binding]; other site 444178003785 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 444178003786 thiS-thiF/thiG interaction site; other site 444178003787 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 444178003788 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 444178003789 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 444178003790 dimer interface [polypeptide binding]; other site 444178003791 substrate binding site [chemical binding]; other site 444178003792 ATP binding site [chemical binding]; other site 444178003793 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 444178003794 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 444178003795 putative active site [active] 444178003796 heme pocket [chemical binding]; other site 444178003797 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 444178003798 putative active site [active] 444178003799 heme pocket [chemical binding]; other site 444178003800 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 444178003801 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 444178003802 metal binding site [ion binding]; metal-binding site 444178003803 active site 444178003804 I-site; other site 444178003805 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 444178003806 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 444178003807 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 444178003808 metal-binding site [ion binding] 444178003809 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 444178003810 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 444178003811 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 444178003812 DNA binding residues [nucleotide binding] 444178003813 dimer interface [polypeptide binding]; other site 444178003814 copper binding site [ion binding]; other site 444178003815 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178003816 dimer interface [polypeptide binding]; other site 444178003817 conserved gate region; other site 444178003818 putative PBP binding loops; other site 444178003819 ABC-ATPase subunit interface; other site 444178003820 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 444178003821 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 444178003822 Walker A/P-loop; other site 444178003823 ATP binding site [chemical binding]; other site 444178003824 Q-loop/lid; other site 444178003825 ABC transporter signature motif; other site 444178003826 Walker B; other site 444178003827 D-loop; other site 444178003828 H-loop/switch region; other site 444178003829 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 444178003830 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178003831 dimer interface [polypeptide binding]; other site 444178003832 conserved gate region; other site 444178003833 ABC-ATPase subunit interface; other site 444178003834 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 444178003835 Uncharacterized conserved protein [Function unknown]; Region: COG5514 444178003836 heme-binding site [chemical binding]; other site 444178003837 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 444178003838 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 444178003839 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 444178003840 NAD(P) binding site [chemical binding]; other site 444178003841 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 444178003842 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 444178003843 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 444178003844 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 444178003845 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 444178003846 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 444178003847 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 444178003848 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 444178003849 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 444178003850 Transcriptional regulator [Transcription]; Region: IclR; COG1414 444178003851 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 444178003852 putative DNA binding site [nucleotide binding]; other site 444178003853 putative Zn2+ binding site [ion binding]; other site 444178003854 Bacterial transcriptional regulator; Region: IclR; pfam01614 444178003855 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 444178003856 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 444178003857 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178003858 dimer interface [polypeptide binding]; other site 444178003859 conserved gate region; other site 444178003860 putative PBP binding loops; other site 444178003861 ABC-ATPase subunit interface; other site 444178003862 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 444178003863 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178003864 dimer interface [polypeptide binding]; other site 444178003865 conserved gate region; other site 444178003866 putative PBP binding loops; other site 444178003867 ABC-ATPase subunit interface; other site 444178003868 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 444178003869 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 444178003870 Walker A/P-loop; other site 444178003871 ATP binding site [chemical binding]; other site 444178003872 Q-loop/lid; other site 444178003873 ABC transporter signature motif; other site 444178003874 Walker B; other site 444178003875 D-loop; other site 444178003876 H-loop/switch region; other site 444178003877 TOBE domain; Region: TOBE_2; pfam08402 444178003878 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 444178003879 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 444178003880 active site pocket [active] 444178003881 Domain of unknown function (DUF718); Region: DUF718; cl01281 444178003882 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 444178003883 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 444178003884 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 444178003885 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 444178003886 NAD binding site [chemical binding]; other site 444178003887 homotetramer interface [polypeptide binding]; other site 444178003888 homodimer interface [polypeptide binding]; other site 444178003889 active site 444178003890 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 444178003891 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 444178003892 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 444178003893 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 444178003894 putative active site pocket [active] 444178003895 metal binding site [ion binding]; metal-binding site 444178003896 integrase; Provisional; Region: PRK09692 444178003897 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 444178003898 active site 444178003899 Int/Topo IB signature motif; other site 444178003900 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 444178003901 Toprim domain; Region: Toprim_3; pfam13362 444178003902 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 444178003903 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 444178003904 Helix-turn-helix domain; Region: HTH_19; pfam12844 444178003905 non-specific DNA binding site [nucleotide binding]; other site 444178003906 salt bridge; other site 444178003907 sequence-specific DNA binding site [nucleotide binding]; other site 444178003908 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 444178003909 Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253 444178003910 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 444178003911 non-specific DNA binding site [nucleotide binding]; other site 444178003912 salt bridge; other site 444178003913 sequence-specific DNA binding site [nucleotide binding]; other site 444178003914 TIR domain; Region: TIR_2; pfam13676 444178003915 zinc-binding protein; Provisional; Region: PRK01343 444178003916 Maf-like protein; Region: Maf; pfam02545 444178003917 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 444178003918 active site 444178003919 dimer interface [polypeptide binding]; other site 444178003920 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 444178003921 rRNA binding site [nucleotide binding]; other site 444178003922 predicted 30S ribosome binding site; other site 444178003923 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 444178003924 Low molecular weight phosphatase family; Region: LMWPc; cd00115 444178003925 active site 444178003926 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 444178003927 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 444178003928 NAD binding site [chemical binding]; other site 444178003929 dimerization interface [polypeptide binding]; other site 444178003930 product binding site; other site 444178003931 substrate binding site [chemical binding]; other site 444178003932 zinc binding site [ion binding]; other site 444178003933 catalytic residues [active] 444178003934 Protein of unknown function (DUF2948); Region: DUF2948; pfam11164 444178003935 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 444178003936 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 444178003937 hinge; other site 444178003938 active site 444178003939 Prophage antirepressor [Transcription]; Region: COG3617 444178003940 BRO family, N-terminal domain; Region: Bro-N; smart01040 444178003941 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 444178003942 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 444178003943 catalytic residues [active] 444178003944 catalytic nucleophile [active] 444178003945 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 444178003946 DNA-binding interface [nucleotide binding]; DNA binding site 444178003947 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 444178003948 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 444178003949 alpha-gamma subunit interface [polypeptide binding]; other site 444178003950 beta-gamma subunit interface [polypeptide binding]; other site 444178003951 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 444178003952 gamma-beta subunit interface [polypeptide binding]; other site 444178003953 alpha-beta subunit interface [polypeptide binding]; other site 444178003954 urease subunit alpha; Reviewed; Region: ureC; PRK13207 444178003955 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 444178003956 subunit interactions [polypeptide binding]; other site 444178003957 active site 444178003958 flap region; other site 444178003959 Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371 444178003960 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 444178003961 dimer interface [polypeptide binding]; other site 444178003962 catalytic residues [active] 444178003963 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 444178003964 UreF; Region: UreF; pfam01730 444178003965 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 444178003966 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 444178003967 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 444178003968 ATP binding site [chemical binding]; other site 444178003969 Mg2+ binding site [ion binding]; other site 444178003970 G-X-G motif; other site 444178003971 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 444178003972 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 444178003973 HlyD family secretion protein; Region: HlyD_3; pfam13437 444178003974 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 444178003975 phenylhydantoinase; Validated; Region: PRK08323 444178003976 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 444178003977 tetramer interface [polypeptide binding]; other site 444178003978 active site 444178003979 allantoate amidohydrolase; Reviewed; Region: PRK12893 444178003980 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 444178003981 active site 444178003982 metal binding site [ion binding]; metal-binding site 444178003983 dimer interface [polypeptide binding]; other site 444178003984 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 444178003985 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 444178003986 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 444178003987 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 444178003988 nudix motif; other site 444178003989 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 444178003990 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 444178003991 homodimer interface [polypeptide binding]; other site 444178003992 active site 444178003993 FMN binding site [chemical binding]; other site 444178003994 substrate binding site [chemical binding]; other site 444178003995 4Fe-4S binding domain; Region: Fer4; cl02805 444178003996 4Fe-4S binding domain; Region: Fer4; pfam00037 444178003997 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 444178003998 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 444178003999 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 444178004000 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 444178004001 putative hydrophobic ligand binding site [chemical binding]; other site 444178004002 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 444178004003 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 444178004004 active site 444178004005 dimer interface [polypeptide binding]; other site 444178004006 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 444178004007 dimer interface [polypeptide binding]; other site 444178004008 active site 444178004009 Predicted deacylase [General function prediction only]; Region: COG3608 444178004010 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 444178004011 active site 444178004012 Zn binding site [ion binding]; other site 444178004013 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 444178004014 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 444178004015 motif II; other site 444178004016 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 444178004017 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 444178004018 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 444178004019 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 444178004020 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 444178004021 acyl-activating enzyme (AAE) consensus motif; other site 444178004022 putative AMP binding site [chemical binding]; other site 444178004023 putative active site [active] 444178004024 putative CoA binding site [chemical binding]; other site 444178004025 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 444178004026 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 444178004027 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 444178004028 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 444178004029 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 444178004030 HlyD family secretion protein; Region: HlyD_3; pfam13437 444178004031 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 444178004032 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 444178004033 substrate binding pocket [chemical binding]; other site 444178004034 membrane-bound complex binding site; other site 444178004035 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 444178004036 CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427 444178004037 DXD motif; other site 444178004038 Uncharacterized conserved protein [Function unknown]; Region: COG2326 444178004039 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 444178004040 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 444178004041 dimer interface [polypeptide binding]; other site 444178004042 phosphorylation site [posttranslational modification] 444178004043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 444178004044 ATP binding site [chemical binding]; other site 444178004045 Mg2+ binding site [ion binding]; other site 444178004046 G-X-G motif; other site 444178004047 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5352 444178004048 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 444178004049 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 444178004050 inhibitor-cofactor binding pocket; inhibition site 444178004051 pyridoxal 5'-phosphate binding site [chemical binding]; other site 444178004052 catalytic residue [active] 444178004053 ornithine carbamoyltransferase; Provisional; Region: PRK00779 444178004054 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 444178004055 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 444178004056 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 444178004057 O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504 444178004058 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 444178004059 homodimer interface [polypeptide binding]; other site 444178004060 substrate-cofactor binding pocket; other site 444178004061 pyridoxal 5'-phosphate binding site [chemical binding]; other site 444178004062 catalytic residue [active] 444178004063 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 444178004064 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 444178004065 trimer interface [polypeptide binding]; other site 444178004066 active site 444178004067 Deoxycytidine deaminase [Nucleotide transport and metabolism]; Region: Dcd; COG0717 444178004068 trimer interface [polypeptide binding]; other site 444178004069 active site 444178004070 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 444178004071 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 444178004072 conserved cys residue [active] 444178004073 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 444178004074 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 444178004075 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 444178004076 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 444178004077 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 444178004078 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 444178004079 quinone interaction residues [chemical binding]; other site 444178004080 active site 444178004081 catalytic residues [active] 444178004082 FMN binding site [chemical binding]; other site 444178004083 substrate binding site [chemical binding]; other site 444178004084 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 444178004085 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 444178004086 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 444178004087 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 444178004088 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 444178004089 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 444178004090 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 444178004091 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 444178004092 active site 444178004093 phosphorylation site [posttranslational modification] 444178004094 intermolecular recognition site; other site 444178004095 dimerization interface [polypeptide binding]; other site 444178004096 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 444178004097 DNA binding residues [nucleotide binding] 444178004098 dimerization interface [polypeptide binding]; other site 444178004099 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 444178004100 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 444178004101 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 444178004102 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 444178004103 substrate-cofactor binding pocket; other site 444178004104 pyridoxal 5'-phosphate binding site [chemical binding]; other site 444178004105 catalytic residue [active] 444178004106 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 444178004107 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 444178004108 putative active site [active] 444178004109 putative metal binding site [ion binding]; other site 444178004110 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 444178004111 Glycosyltransferase family 29 (sialyltransferase); Region: Glyco_transf_29; pfam00777 444178004112 Transcriptional regulator [Transcription]; Region: LysR; COG0583 444178004113 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 444178004114 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 444178004115 putative dimerization interface [polypeptide binding]; other site 444178004116 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 444178004117 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 444178004118 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 444178004119 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 444178004120 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 444178004121 pantoate--beta-alanine ligase; Region: panC; TIGR00018 444178004122 Pantoate-beta-alanine ligase; Region: PanC; cd00560 444178004123 active site 444178004124 ATP-binding site [chemical binding]; other site 444178004125 pantoate-binding site; other site 444178004126 HXXH motif; other site 444178004127 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 444178004128 active site 444178004129 oligomerization interface [polypeptide binding]; other site 444178004130 metal binding site [ion binding]; metal-binding site 444178004131 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 444178004132 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 444178004133 FAD binding pocket [chemical binding]; other site 444178004134 FAD binding motif [chemical binding]; other site 444178004135 phosphate binding motif [ion binding]; other site 444178004136 beta-alpha-beta structure motif; other site 444178004137 NAD binding pocket [chemical binding]; other site 444178004138 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 444178004139 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 444178004140 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 444178004141 dimer interface [polypeptide binding]; other site 444178004142 active site 444178004143 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 444178004144 catalytic residues [active] 444178004145 substrate binding site [chemical binding]; other site 444178004146 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 444178004147 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 444178004148 NAD(P) binding pocket [chemical binding]; other site 444178004149 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 444178004150 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 444178004151 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 444178004152 multidrug efflux protein; Reviewed; Region: PRK01766 444178004153 cation binding site [ion binding]; other site 444178004154 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 444178004155 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 444178004156 Cache domain; Region: Cache_2; pfam08269 444178004157 Histidine kinase; Region: HisKA_3; pfam07730 444178004158 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 444178004159 ATP binding site [chemical binding]; other site 444178004160 Mg2+ binding site [ion binding]; other site 444178004161 G-X-G motif; other site 444178004162 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 444178004163 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 444178004164 active site 444178004165 phosphorylation site [posttranslational modification] 444178004166 intermolecular recognition site; other site 444178004167 dimerization interface [polypeptide binding]; other site 444178004168 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 444178004169 DNA binding residues [nucleotide binding] 444178004170 dimerization interface [polypeptide binding]; other site 444178004171 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 444178004172 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 444178004173 DctM-like transporters; Region: DctM; pfam06808 444178004174 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 444178004175 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 444178004176 hypothetical protein; Provisional; Region: PRK11171 444178004177 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 444178004178 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 444178004179 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 444178004180 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 444178004181 active site 444178004182 catalytic site [active] 444178004183 tetramer interface [polypeptide binding]; other site 444178004184 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 444178004185 Transthyretin_like. This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase). TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl17222 444178004186 homotetramer interface [polypeptide binding]; other site 444178004187 active site 444178004188 Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [Nucleotide transport and metabolism]; Region: XdhA; COG4630 444178004189 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 444178004190 catalytic loop [active] 444178004191 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 444178004192 iron binding site [ion binding]; other site 444178004193 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 444178004194 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 444178004195 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 444178004196 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 444178004197 XdhC Rossmann domain; Region: XdhC_C; pfam13478 444178004198 Transcriptional regulator [Transcription]; Region: LysR; COG0583 444178004199 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 444178004200 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 444178004201 putative effector binding pocket; other site 444178004202 dimerization interface [polypeptide binding]; other site 444178004203 guanine deaminase; Provisional; Region: PRK09228 444178004204 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 444178004205 active site 444178004206 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 444178004207 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 444178004208 MOFRL family; Region: MOFRL; pfam05161 444178004209 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 444178004210 Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456 444178004211 FixH; Region: FixH; pfam05751 444178004212 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 444178004213 4Fe-4S binding domain; Region: Fer4_5; pfam12801 444178004214 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 444178004215 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 444178004216 Cytochrome c; Region: Cytochrom_C; pfam00034 444178004217 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 444178004218 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 444178004219 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 444178004220 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 444178004221 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 444178004222 Low-spin heme binding site [chemical binding]; other site 444178004223 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 444178004224 Putative water exit pathway; other site 444178004225 Binuclear center (active site) [active] 444178004226 Putative proton exit pathway; other site 444178004227 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 444178004228 metal binding site 2 [ion binding]; metal-binding site 444178004229 putative DNA binding helix; other site 444178004230 metal binding site 1 [ion binding]; metal-binding site 444178004231 dimer interface [polypeptide binding]; other site 444178004232 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 444178004233 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 444178004234 catalytic residues [active] 444178004235 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 444178004236 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 444178004237 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 444178004238 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 444178004239 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 444178004240 DNA binding site [nucleotide binding] 444178004241 active site 444178004242 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 444178004243 ArsC family; Region: ArsC; pfam03960 444178004244 putative catalytic residues [active] 444178004245 Predicted membrane protein [Function unknown]; Region: COG4129 444178004246 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 444178004247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 444178004248 putative substrate translocation pore; other site 444178004249 Major Facilitator Superfamily; Region: MFS_1; pfam07690 444178004250 microcin B17 transporter; Reviewed; Region: PRK11098 444178004251 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 444178004252 GTP-binding protein Der; Reviewed; Region: PRK00093 444178004253 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 444178004254 G1 box; other site 444178004255 GTP/Mg2+ binding site [chemical binding]; other site 444178004256 Switch I region; other site 444178004257 G2 box; other site 444178004258 Switch II region; other site 444178004259 G3 box; other site 444178004260 G4 box; other site 444178004261 G5 box; other site 444178004262 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 444178004263 G1 box; other site 444178004264 GTP/Mg2+ binding site [chemical binding]; other site 444178004265 Switch I region; other site 444178004266 G2 box; other site 444178004267 G3 box; other site 444178004268 Switch II region; other site 444178004269 G4 box; other site 444178004270 G5 box; other site 444178004271 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 444178004272 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 444178004273 nucleotide binding site [chemical binding]; other site 444178004274 putative NEF/HSP70 interaction site [polypeptide binding]; other site 444178004275 SBD interface [polypeptide binding]; other site 444178004276 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5336 444178004277 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 444178004278 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 444178004279 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 444178004280 F0F1 ATP synthase subunit B'; Validated; Region: PRK09174 444178004281 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 444178004282 F0F1 ATP synthase subunit B; Validated; Region: PRK09173 444178004283 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 444178004284 RNA/DNA hybrid binding site [nucleotide binding]; other site 444178004285 active site 444178004286 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 444178004287 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 444178004288 FeS/SAM binding site; other site 444178004289 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 444178004290 active site 444178004291 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 444178004292 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 444178004293 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 444178004294 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 444178004295 tandem repeat interface [polypeptide binding]; other site 444178004296 oligomer interface [polypeptide binding]; other site 444178004297 active site residues [active] 444178004298 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 444178004299 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 444178004300 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 444178004301 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 444178004302 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 444178004303 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 444178004304 substrate binding pocket [chemical binding]; other site 444178004305 chain length determination region; other site 444178004306 substrate-Mg2+ binding site; other site 444178004307 catalytic residues [active] 444178004308 aspartate-rich region 1; other site 444178004309 active site lid residues [active] 444178004310 aspartate-rich region 2; other site 444178004311 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 444178004312 binding surface 444178004313 TPR motif; other site 444178004314 TPR repeat; Region: TPR_11; pfam13414 444178004315 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 444178004316 binding surface 444178004317 TPR motif; other site 444178004318 TPR repeat; Region: TPR_11; pfam13414 444178004319 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 444178004320 binding surface 444178004321 TPR motif; other site 444178004322 TPR repeat; Region: TPR_11; pfam13414 444178004323 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 444178004324 dimer interface [polypeptide binding]; other site 444178004325 motif 1; other site 444178004326 active site 444178004327 motif 2; other site 444178004328 motif 3; other site 444178004329 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 444178004330 DALR anticodon binding domain; Region: DALR_1; pfam05746 444178004331 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 444178004332 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 444178004333 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 444178004334 FAD binding domain; Region: FAD_binding_4; pfam01565 444178004335 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 444178004336 Predicted transcriptional regulator [Transcription]; Region: COG3905 444178004337 enoyl-CoA hydratase; Provisional; Region: PRK06688 444178004338 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 444178004339 substrate binding site [chemical binding]; other site 444178004340 oxyanion hole (OAH) forming residues; other site 444178004341 trimer interface [polypeptide binding]; other site 444178004342 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 444178004343 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 444178004344 active site 444178004345 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 444178004346 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 444178004347 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 444178004348 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 444178004349 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 444178004350 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878 444178004351 UbiA prenyltransferase family; Region: UbiA; pfam01040 444178004352 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 444178004353 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 444178004354 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 444178004355 chaperone protein DnaJ; Provisional; Region: PRK14299 444178004356 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 444178004357 HSP70 interaction site [polypeptide binding]; other site 444178004358 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 444178004359 dimer interface [polypeptide binding]; other site 444178004360 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 444178004361 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 444178004362 NAD binding site [chemical binding]; other site 444178004363 homotetramer interface [polypeptide binding]; other site 444178004364 homodimer interface [polypeptide binding]; other site 444178004365 substrate binding site [chemical binding]; other site 444178004366 active site 444178004367 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 444178004368 catalytic core [active] 444178004369 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 444178004370 DNA-binding site [nucleotide binding]; DNA binding site 444178004371 RNA-binding motif; other site 444178004372 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 444178004373 putative acyl-acceptor binding pocket; other site 444178004374 Protein of unknown function (DUF1344); Region: DUF1344; pfam07076 444178004375 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 444178004376 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 444178004377 Tetramer interface [polypeptide binding]; other site 444178004378 active site 444178004379 FMN-binding site [chemical binding]; other site 444178004380 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09314 444178004381 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 444178004382 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 444178004383 dimerization interface [polypeptide binding]; other site 444178004384 active site 444178004385 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 444178004386 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 444178004387 putative active site [active] 444178004388 Zn binding site [ion binding]; other site 444178004389 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 444178004390 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 444178004391 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 444178004392 Predicted membrane protein [Function unknown]; Region: COG2261 444178004393 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3753 444178004394 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 444178004395 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 444178004396 TPP-binding site; other site 444178004397 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 444178004398 PYR/PP interface [polypeptide binding]; other site 444178004399 dimer interface [polypeptide binding]; other site 444178004400 TPP binding site [chemical binding]; other site 444178004401 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 444178004402 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 444178004403 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 444178004404 RNA binding surface [nucleotide binding]; other site 444178004405 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 444178004406 S-adenosylmethionine binding site [chemical binding]; other site 444178004407 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 444178004408 Methyltransferase domain; Region: Methyltransf_26; pfam13659 444178004409 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 444178004410 Predicted periplasmic protein [General function prediction only]; Region: COG3895 444178004411 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 444178004412 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 444178004413 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 444178004414 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 444178004415 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 444178004416 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 444178004417 Walker A/P-loop; other site 444178004418 ATP binding site [chemical binding]; other site 444178004419 Q-loop/lid; other site 444178004420 ABC transporter signature motif; other site 444178004421 Walker B; other site 444178004422 D-loop; other site 444178004423 H-loop/switch region; other site 444178004424 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 444178004425 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 444178004426 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 444178004427 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 444178004428 classical (c) SDRs; Region: SDR_c; cd05233 444178004429 NAD(P) binding site [chemical binding]; other site 444178004430 active site 444178004431 amidophosphoribosyltransferase; Provisional; Region: PRK09123 444178004432 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 444178004433 active site 444178004434 tetramer interface [polypeptide binding]; other site 444178004435 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 444178004436 active site 444178004437 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 444178004438 Colicin V production protein; Region: Colicin_V; pfam02674 444178004439 DNA repair protein RadA; Provisional; Region: PRK11823 444178004440 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 444178004441 Walker A motif/ATP binding site; other site 444178004442 ATP binding site [chemical binding]; other site 444178004443 Walker B motif; other site 444178004444 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 444178004445 replicative DNA helicase; Provisional; Region: PRK09165 444178004446 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 444178004447 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 444178004448 Walker A motif; other site 444178004449 ATP binding site [chemical binding]; other site 444178004450 Walker B motif; other site 444178004451 DNA binding loops [nucleotide binding] 444178004452 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 444178004453 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 444178004454 S-adenosylmethionine binding site [chemical binding]; other site 444178004455 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 444178004456 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 444178004457 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 444178004458 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 444178004459 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 444178004460 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 444178004461 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 444178004462 3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936 444178004463 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 444178004464 NAD(P) binding site [chemical binding]; other site 444178004465 homotetramer interface [polypeptide binding]; other site 444178004466 homodimer interface [polypeptide binding]; other site 444178004467 active site 444178004468 acyl carrier protein; Provisional; Region: acpP; PRK00982 444178004469 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 444178004470 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 444178004471 dimer interface [polypeptide binding]; other site 444178004472 active site 444178004473 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 444178004474 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 444178004475 dimerization interface [polypeptide binding]; other site 444178004476 Uncharacterized stress-induced protein [Function unknown]; Region: COG1561 444178004477 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 444178004478 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 444178004479 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 444178004480 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 444178004481 catalytic site [active] 444178004482 G-X2-G-X-G-K; other site 444178004483 protease TldD; Provisional; Region: tldD; PRK10735 444178004484 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 444178004485 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 444178004486 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 444178004487 Subunit I/III interface [polypeptide binding]; other site 444178004488 D-pathway; other site 444178004489 Subunit I/VIIc interface [polypeptide binding]; other site 444178004490 Subunit I/IV interface [polypeptide binding]; other site 444178004491 Subunit I/II interface [polypeptide binding]; other site 444178004492 Low-spin heme (heme a) binding site [chemical binding]; other site 444178004493 Subunit I/VIIa interface [polypeptide binding]; other site 444178004494 Subunit I/VIa interface [polypeptide binding]; other site 444178004495 Dimer interface; other site 444178004496 Putative water exit pathway; other site 444178004497 Binuclear center (heme a3/CuB) [ion binding]; other site 444178004498 K-pathway; other site 444178004499 Subunit I/Vb interface [polypeptide binding]; other site 444178004500 Putative proton exit pathway; other site 444178004501 Subunit I/VIb interface; other site 444178004502 Subunit I/VIc interface [polypeptide binding]; other site 444178004503 Electron transfer pathway; other site 444178004504 Subunit I/VIIIb interface [polypeptide binding]; other site 444178004505 Subunit I/VIIb interface [polypeptide binding]; other site 444178004506 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 444178004507 UbiA prenyltransferase family; Region: UbiA; pfam01040 444178004508 Cytochrome oxidase assembly factor [Posttranslational modification, protein turnover, chaperones]; Region: COX11; COG3175 444178004509 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 444178004510 Subunit III/VIIa interface [polypeptide binding]; other site 444178004511 Phospholipid binding site [chemical binding]; other site 444178004512 Subunit I/III interface [polypeptide binding]; other site 444178004513 Subunit III/VIb interface [polypeptide binding]; other site 444178004514 Subunit III/VIa interface; other site 444178004515 Subunit III/Vb interface [polypeptide binding]; other site 444178004516 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349 444178004517 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 444178004518 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 444178004519 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 444178004520 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 444178004521 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 444178004522 putative active site [active] 444178004523 putative substrate binding site [chemical binding]; other site 444178004524 ATP binding site [chemical binding]; other site 444178004525 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 444178004526 RNA/DNA hybrid binding site [nucleotide binding]; other site 444178004527 active site 444178004528 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 444178004529 catalytic triad [active] 444178004530 dimer interface [polypeptide binding]; other site 444178004531 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 444178004532 hypothetical protein; Validated; Region: PRK00228 444178004533 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 444178004534 PAS fold; Region: PAS_3; pfam08447 444178004535 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 444178004536 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 444178004537 metal binding site [ion binding]; metal-binding site 444178004538 active site 444178004539 I-site; other site 444178004540 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 444178004541 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 444178004542 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 444178004543 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 444178004544 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 444178004545 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 444178004546 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 444178004547 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 444178004548 pyridoxal 5'-phosphate binding site [chemical binding]; other site 444178004549 catalytic residue [active] 444178004550 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 444178004551 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 444178004552 active site 444178004553 motif I; other site 444178004554 motif II; other site 444178004555 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 444178004556 DNA methylase; Region: N6_N4_Mtase; pfam01555 444178004557 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 444178004558 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 444178004559 motif II; other site 444178004560 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 444178004561 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 444178004562 minor groove reading motif; other site 444178004563 helix-hairpin-helix signature motif; other site 444178004564 substrate binding pocket [chemical binding]; other site 444178004565 active site 444178004566 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 444178004567 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 444178004568 DNA binding and oxoG recognition site [nucleotide binding] 444178004569 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5389 444178004570 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 444178004571 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 444178004572 catalytic residues [active] 444178004573 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 444178004574 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 444178004575 Walker A/P-loop; other site 444178004576 ATP binding site [chemical binding]; other site 444178004577 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 444178004578 ABC transporter signature motif; other site 444178004579 Walker B; other site 444178004580 D-loop; other site 444178004581 H-loop/switch region; other site 444178004582 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 444178004583 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 444178004584 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 444178004585 pyruvate phosphate dikinase; Provisional; Region: PRK09279 444178004586 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 444178004587 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 444178004588 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 444178004589 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 444178004590 Putative catalytic NodB homology domain of uncharacterized BH0857 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH0857_like; cd10955 444178004591 NodB motif; other site 444178004592 putative active site [active] 444178004593 putative catalytic site [active] 444178004594 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 444178004595 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 444178004596 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 444178004597 ureidoglycolate hydrolase; Provisional; Region: PRK03606 444178004598 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 444178004599 active site 444178004600 homotetramer interface [polypeptide binding]; other site 444178004601 Protein of unknown function (DUF2793); Region: DUF2793; pfam10983 444178004602 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 444178004603 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 444178004604 NAD(P) binding site [chemical binding]; other site 444178004605 homodimer interface [polypeptide binding]; other site 444178004606 substrate binding site [chemical binding]; other site 444178004607 active site 444178004608 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 444178004609 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 444178004610 Mg++ binding site [ion binding]; other site 444178004611 putative catalytic motif [active] 444178004612 putative substrate binding site [chemical binding]; other site 444178004613 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 444178004614 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 444178004615 active site 444178004616 substrate binding site [chemical binding]; other site 444178004617 cosubstrate binding site; other site 444178004618 catalytic site [active] 444178004619 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 444178004620 Walker A/P-loop; other site 444178004621 ATP binding site [chemical binding]; other site 444178004622 ABC transporter; Region: ABC_tran; pfam00005 444178004623 Q-loop/lid; other site 444178004624 ABC transporter signature motif; other site 444178004625 Walker B; other site 444178004626 D-loop; other site 444178004627 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 444178004628 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 444178004629 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 444178004630 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 444178004631 inhibitor-cofactor binding pocket; inhibition site 444178004632 pyridoxal 5'-phosphate binding site [chemical binding]; other site 444178004633 catalytic residue [active] 444178004634 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 444178004635 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 444178004636 homotetramer interface [polypeptide binding]; other site 444178004637 NADP-binding site; other site 444178004638 substrate binding site [chemical binding]; other site 444178004639 homodimer interface [polypeptide binding]; other site 444178004640 active site 444178004641 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 444178004642 Integrase core domain; Region: rve; pfam00665 444178004643 DDE domain; Region: DDE_Tnp_IS240; pfam13610 444178004644 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 444178004645 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 444178004646 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 444178004647 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 444178004648 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 444178004649 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 444178004650 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 444178004651 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 444178004652 Integrase core domain; Region: rve; pfam00665 444178004653 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 444178004654 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 444178004655 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 444178004656 Integrase core domain; Region: rve_3; cl15866 444178004657 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 444178004658 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 444178004659 active site 444178004660 substrate binding site [chemical binding]; other site 444178004661 metal binding site [ion binding]; metal-binding site 444178004662 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 444178004663 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 444178004664 Substrate binding site; other site 444178004665 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 444178004666 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 444178004667 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 444178004668 Walker A/P-loop; other site 444178004669 ATP binding site [chemical binding]; other site 444178004670 Q-loop/lid; other site 444178004671 ABC transporter signature motif; other site 444178004672 Walker B; other site 444178004673 D-loop; other site 444178004674 H-loop/switch region; other site 444178004675 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 444178004676 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 444178004677 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 444178004678 TM-ABC transporter signature motif; other site 444178004679 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 444178004680 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_3; cd06311 444178004681 putative ligand binding site [chemical binding]; other site 444178004682 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 444178004683 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 444178004684 Metal-binding active site; metal-binding site 444178004685 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 444178004686 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 444178004687 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 444178004688 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 444178004689 xylose isomerase; Provisional; Region: PRK05474 444178004690 xylose isomerase; Region: xylose_isom_A; TIGR02630 444178004691 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 444178004692 N- and C-terminal domain interface [polypeptide binding]; other site 444178004693 D-xylulose kinase; Region: XylB; TIGR01312 444178004694 active site 444178004695 MgATP binding site [chemical binding]; other site 444178004696 catalytic site [active] 444178004697 metal binding site [ion binding]; metal-binding site 444178004698 xylulose binding site [chemical binding]; other site 444178004699 homodimer interface [polypeptide binding]; other site 444178004700 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 444178004701 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 444178004702 DNA binding site [nucleotide binding] 444178004703 domain linker motif; other site 444178004704 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 444178004705 putative ligand binding site [chemical binding]; other site 444178004706 Helix-turn-helix domain; Region: HTH_18; pfam12833 444178004707 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 444178004708 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 444178004709 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 444178004710 tetrameric interface [polypeptide binding]; other site 444178004711 NAD binding site [chemical binding]; other site 444178004712 catalytic residues [active] 444178004713 choline dehydrogenase; Validated; Region: PRK02106 444178004714 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 444178004715 transcriptional regulator BetI; Validated; Region: PRK00767 444178004716 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 444178004717 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 444178004718 L-asparaginase II [Amino acid transport and metabolism]; Region: AnsA; COG4448 444178004719 transcription elongation factor regulatory protein; Validated; Region: PRK06342 444178004720 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 444178004721 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 444178004722 putative addiction module antidote; Region: doc_partner; TIGR02609 444178004723 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 444178004724 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 444178004725 Cl binding site [ion binding]; other site 444178004726 oligomer interface [polypeptide binding]; other site 444178004727 Transcriptional regulators [Transcription]; Region: FadR; COG2186 444178004728 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 444178004729 DNA-binding site [nucleotide binding]; DNA binding site 444178004730 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 444178004731 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 444178004732 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 444178004733 putative substrate translocation pore; other site 444178004734 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 444178004735 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 444178004736 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 444178004737 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 444178004738 motif II; other site 444178004739 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 444178004740 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 444178004741 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 444178004742 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 444178004743 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 444178004744 Predicted transcriptional regulator [Transcription]; Region: COG4957 444178004745 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 444178004746 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 444178004747 DnaA box-binding interface [nucleotide binding]; other site 444178004748 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 444178004749 Flavin Reductases; Region: FlaRed; cl00801 444178004750 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 444178004751 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 444178004752 dimer interface [polypeptide binding]; other site 444178004753 phosphorylation site [posttranslational modification] 444178004754 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 444178004755 ATP binding site [chemical binding]; other site 444178004756 Mg2+ binding site [ion binding]; other site 444178004757 G-X-G motif; other site 444178004758 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 444178004759 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 444178004760 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 444178004761 Uncharacterized conserved protein [Function unknown]; Region: COG5447 444178004762 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330 444178004763 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 444178004764 Predicted integral membrane protein [Function unknown]; Region: COG5436 444178004765 Uncharacterized conserved protein [Function unknown]; Region: COG5402 444178004766 Transglycosylase; Region: Transgly; pfam00912 444178004767 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 444178004768 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 444178004769 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 444178004770 Uncharacterized conserved protein [Function unknown]; Region: COG5323 444178004771 Uncharacterized conserved protein [Function unknown]; Region: COG5323 444178004772 Terminase-like family; Region: Terminase_6; pfam03237 444178004773 Phage-related protein [Function unknown]; Region: COG4695 444178004774 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 444178004775 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 444178004776 phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215 444178004777 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 444178004778 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 444178004779 oligomerization interface [polypeptide binding]; other site 444178004780 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 444178004781 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 444178004782 Protein of unknown function (DUF3356); Region: DUF3356; pfam11836 444178004783 Phage-related minor tail protein [Function unknown]; Region: COG5281 444178004784 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 444178004785 putative phage cell wall peptidase, NlpC/P60 family; Region: phage_NlpC_fam; TIGR02219 444178004786 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 444178004787 Putative phage tail protein; Region: Phage-tail_3; pfam13550 444178004788 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 444178004789 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 444178004790 active site 444178004791 phosphorylation site [posttranslational modification] 444178004792 intermolecular recognition site; other site 444178004793 dimerization interface [polypeptide binding]; other site 444178004794 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 444178004795 DNA binding site [nucleotide binding] 444178004796 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 444178004797 HAMP domain; Region: HAMP; pfam00672 444178004798 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 444178004799 ATP binding site [chemical binding]; other site 444178004800 Mg2+ binding site [ion binding]; other site 444178004801 G-X-G motif; other site 444178004802 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 444178004803 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 444178004804 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 444178004805 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 444178004806 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 444178004807 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 444178004808 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 444178004809 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 444178004810 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 444178004811 protein binding site [polypeptide binding]; other site 444178004812 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 444178004813 protein binding site [polypeptide binding]; other site 444178004814 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 444178004815 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 444178004816 active site 444178004817 phosphorylation site [posttranslational modification] 444178004818 intermolecular recognition site; other site 444178004819 dimerization interface [polypeptide binding]; other site 444178004820 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 444178004821 DNA binding site [nucleotide binding] 444178004822 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 444178004823 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 444178004824 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 444178004825 dimerization interface [polypeptide binding]; other site 444178004826 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 444178004827 dimer interface [polypeptide binding]; other site 444178004828 phosphorylation site [posttranslational modification] 444178004829 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 444178004830 ATP binding site [chemical binding]; other site 444178004831 Mg2+ binding site [ion binding]; other site 444178004832 G-X-G motif; other site 444178004833 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 444178004834 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 444178004835 metal binding triad; other site 444178004836 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 444178004837 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 444178004838 metal binding triad; other site 444178004839 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 444178004840 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 444178004841 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298 444178004842 O-Antigen ligase; Region: Wzy_C; pfam04932 444178004843 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 444178004844 PAS fold; Region: PAS_3; pfam08447 444178004845 putative active site [active] 444178004846 heme pocket [chemical binding]; other site 444178004847 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 444178004848 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 444178004849 dimer interface [polypeptide binding]; other site 444178004850 phosphorylation site [posttranslational modification] 444178004851 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 444178004852 ATP binding site [chemical binding]; other site 444178004853 Mg2+ binding site [ion binding]; other site 444178004854 G-X-G motif; other site 444178004855 aminopeptidase N; Provisional; Region: pepN; PRK14015 444178004856 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 444178004857 active site 444178004858 Zn binding site [ion binding]; other site 444178004859 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 444178004860 EamA-like transporter family; Region: EamA; pfam00892 444178004861 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 444178004862 Major Facilitator Superfamily; Region: MFS_1; pfam07690 444178004863 putative substrate translocation pore; other site 444178004864 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 444178004865 Fe-S cluster binding site [ion binding]; other site 444178004866 active site 444178004867 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 444178004868 hydroxyglutarate oxidase; Provisional; Region: PRK11728 444178004869 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 444178004870 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3021 444178004871 putative catalytic site [active] 444178004872 putative metal binding site [ion binding]; other site 444178004873 putative phosphate binding site [ion binding]; other site 444178004874 AMP nucleosidase; Provisional; Region: PRK08292 444178004875 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 444178004876 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 444178004877 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 444178004878 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 444178004879 C-terminal domain interface [polypeptide binding]; other site 444178004880 GSH binding site (G-site) [chemical binding]; other site 444178004881 dimer interface [polypeptide binding]; other site 444178004882 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 444178004883 N-terminal domain interface [polypeptide binding]; other site 444178004884 putative dimer interface [polypeptide binding]; other site 444178004885 active site 444178004886 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 444178004887 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 444178004888 Uncharacterized conserved protein [Function unknown]; Region: COG1284 444178004889 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 444178004890 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 444178004891 histidinol-phosphate aminotransferase; Provisional; Region: PRK08153 444178004892 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 444178004893 pyridoxal 5'-phosphate binding site [chemical binding]; other site 444178004894 homodimer interface [polypeptide binding]; other site 444178004895 catalytic residue [active] 444178004896 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 444178004897 active site 444178004898 DNA binding site [nucleotide binding] 444178004899 Int/Topo IB signature motif; other site 444178004900 Porin subfamily; Region: Porin_2; pfam02530 444178004901 Uncharacterized conserved protein [Function unknown]; Region: COG3743 444178004902 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 444178004903 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 444178004904 N-acetyl-D-glucosamine binding site [chemical binding]; other site 444178004905 catalytic residue [active] 444178004906 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 444178004907 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 444178004908 dimer interface [polypeptide binding]; other site 444178004909 active site 444178004910 catalytic residue [active] 444178004911 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 444178004912 SmpB-tmRNA interface; other site 444178004913 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 444178004914 Fe-S cluster binding site [ion binding]; other site 444178004915 DNA binding site [nucleotide binding] 444178004916 active site 444178004917 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 444178004918 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 444178004919 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 444178004920 Zn2+ binding site [ion binding]; other site 444178004921 Mg2+ binding site [ion binding]; other site 444178004922 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 444178004923 synthetase active site [active] 444178004924 NTP binding site [chemical binding]; other site 444178004925 metal binding site [ion binding]; metal-binding site 444178004926 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 444178004927 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 444178004928 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 444178004929 active site 444178004930 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 444178004931 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 444178004932 ligand binding site [chemical binding]; other site 444178004933 flexible hinge region; other site 444178004934 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 444178004935 putative switch regulator; other site 444178004936 non-specific DNA interactions [nucleotide binding]; other site 444178004937 DNA binding site [nucleotide binding] 444178004938 sequence specific DNA binding site [nucleotide binding]; other site 444178004939 putative cAMP binding site [chemical binding]; other site 444178004940 coproporphyrinogen III oxidase; Provisional; Region: PRK13347 444178004941 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 444178004942 FeS/SAM binding site; other site 444178004943 HemN C-terminal domain; Region: HemN_C; pfam06969 444178004944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 444178004945 Major Facilitator Superfamily; Region: MFS_1; pfam07690 444178004946 putative substrate translocation pore; other site 444178004947 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 444178004948 Helix-turn-helix domain; Region: HTH_18; pfam12833 444178004949 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 444178004950 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3216 444178004951 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 444178004952 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 444178004953 Catalytic site [active] 444178004954 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 444178004955 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 444178004956 ribonuclease III; Reviewed; Region: PRK12371 444178004957 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 444178004958 dimerization interface [polypeptide binding]; other site 444178004959 active site 444178004960 metal binding site [ion binding]; metal-binding site 444178004961 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 444178004962 dsRNA binding site [nucleotide binding]; other site 444178004963 GTPase Era; Reviewed; Region: era; PRK00089 444178004964 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 444178004965 G1 box; other site 444178004966 GTP/Mg2+ binding site [chemical binding]; other site 444178004967 Switch I region; other site 444178004968 G2 box; other site 444178004969 Switch II region; other site 444178004970 G3 box; other site 444178004971 G4 box; other site 444178004972 G5 box; other site 444178004973 KH domain; Region: KH_2; pfam07650 444178004974 Recombination protein O N terminal; Region: RecO_N; pfam11967 444178004975 DNA repair protein RecO; Region: reco; TIGR00613 444178004976 Recombination protein O C terminal; Region: RecO_C; pfam02565 444178004977 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 444178004978 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 444178004979 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 444178004980 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 444178004981 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 444178004982 dihydroorotase; Validated; Region: PRK09060 444178004983 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 444178004984 active site 444178004985 TIGR02301 family protein; Region: TIGR02301 444178004986 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 444178004987 nudix motif; other site 444178004988 Lysine efflux permease [General function prediction only]; Region: COG1279 444178004989 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 444178004990 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 444178004991 active site 444178004992 HIGH motif; other site 444178004993 nucleotide binding site [chemical binding]; other site 444178004994 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 444178004995 KMSKS motif; other site 444178004996 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 444178004997 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 444178004998 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 444178004999 active site 444178005000 catalytic residues [active] 444178005001 metal binding site [ion binding]; metal-binding site 444178005002 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 444178005003 Predicted permeases [General function prediction only]; Region: RarD; COG2962 444178005004 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 444178005005 Peptidase family M23; Region: Peptidase_M23; pfam01551 444178005006 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 444178005007 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 444178005008 S-adenosylmethionine binding site [chemical binding]; other site 444178005009 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312 444178005010 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 444178005011 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 444178005012 SurA N-terminal domain; Region: SurA_N; pfam09312 444178005013 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 444178005014 OstA-like protein; Region: OstA; cl00844 444178005015 Organic solvent tolerance protein; Region: OstA_C; pfam04453 444178005016 Predicted permeases [General function prediction only]; Region: COG0795 444178005017 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 444178005018 Predicted permeases [General function prediction only]; Region: COG0795 444178005019 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 444178005020 multifunctional aminopeptidase A; Provisional; Region: PRK00913 444178005021 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 444178005022 interface (dimer of trimers) [polypeptide binding]; other site 444178005023 Substrate-binding/catalytic site; other site 444178005024 Zn-binding sites [ion binding]; other site 444178005025 DNA polymerase III subunit chi; Validated; Region: PRK05728 444178005026 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 444178005027 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 444178005028 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 444178005029 Walker A/P-loop; other site 444178005030 ATP binding site [chemical binding]; other site 444178005031 Q-loop/lid; other site 444178005032 ABC transporter signature motif; other site 444178005033 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 444178005034 Walker B; other site 444178005035 D-loop; other site 444178005036 ABC transporter; Region: ABC_tran_2; pfam12848 444178005037 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 444178005038 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 444178005039 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 444178005040 active site 444178005041 multimer interface [polypeptide binding]; other site 444178005042 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 444178005043 Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187 444178005044 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 444178005045 MoaE homodimer interface [polypeptide binding]; other site 444178005046 MoaD interaction [polypeptide binding]; other site 444178005047 active site residues [active] 444178005048 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 444178005049 MoaE interaction surface [polypeptide binding]; other site 444178005050 MoeB interaction surface [polypeptide binding]; other site 444178005051 thiocarboxylated glycine; other site 444178005052 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 444178005053 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 444178005054 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 444178005055 GIY-YIG motif/motif A; other site 444178005056 active site 444178005057 catalytic site [active] 444178005058 putative DNA binding site [nucleotide binding]; other site 444178005059 metal binding site [ion binding]; metal-binding site 444178005060 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 444178005061 short chain dehydrogenase; Provisional; Region: PRK09134 444178005062 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 444178005063 NADP binding site [chemical binding]; other site 444178005064 substrate binding pocket [chemical binding]; other site 444178005065 active site 444178005066 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 444178005067 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 444178005068 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 444178005069 putative C-terminal domain interface [polypeptide binding]; other site 444178005070 putative GSH binding site (G-site) [chemical binding]; other site 444178005071 putative dimer interface [polypeptide binding]; other site 444178005072 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 444178005073 dimer interface [polypeptide binding]; other site 444178005074 N-terminal domain interface [polypeptide binding]; other site 444178005075 putative substrate binding pocket (H-site) [chemical binding]; other site 444178005076 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 444178005077 B1 nucleotide binding pocket [chemical binding]; other site 444178005078 B2 nucleotide binding pocket [chemical binding]; other site 444178005079 CAS motifs; other site 444178005080 active site 444178005081 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 444178005082 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 444178005083 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 444178005084 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 444178005085 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 444178005086 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 444178005087 putative [4Fe-4S] binding site [ion binding]; other site 444178005088 putative molybdopterin cofactor binding site [chemical binding]; other site 444178005089 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 444178005090 putative molybdopterin cofactor binding site; other site 444178005091 Protein of unknown function (DUF992); Region: DUF992; pfam06186 444178005092 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 444178005093 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 444178005094 active site 444178005095 substrate binding site [chemical binding]; other site 444178005096 cosubstrate binding site; other site 444178005097 catalytic site [active] 444178005098 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 444178005099 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 444178005100 dimerization interface [polypeptide binding]; other site 444178005101 putative ATP binding site [chemical binding]; other site 444178005102 Domain of unknown function DUF20; Region: UPF0118; pfam01594 444178005103 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 444178005104 hypothetical protein; Validated; Region: PRK09087 444178005105 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 444178005106 Walker A motif; other site 444178005107 ATP binding site [chemical binding]; other site 444178005108 Walker B motif; other site 444178005109 arginine finger; other site 444178005110 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 444178005111 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 444178005112 NAD(P) binding site [chemical binding]; other site 444178005113 active site 444178005114 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 444178005115 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 444178005116 putative NAD(P) binding site [chemical binding]; other site 444178005117 putative active site [active] 444178005118 L-lactate permease; Region: Lactate_perm; cl00701 444178005119 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 444178005120 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 444178005121 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 444178005122 active site 444178005123 catalytic site [active] 444178005124 substrate binding site [chemical binding]; other site 444178005125 Archaeal adenylate kinase [Nucleotide transport and metabolism]; Region: AdkA; COG2019 444178005126 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 444178005127 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 444178005128 non-specific DNA binding site [nucleotide binding]; other site 444178005129 salt bridge; other site 444178005130 sequence-specific DNA binding site [nucleotide binding]; other site 444178005131 Uncharacterized conserved protein [Function unknown]; Region: COG4933 444178005132 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 444178005133 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 444178005134 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 444178005135 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 444178005136 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 444178005137 AAA domain; Region: AAA_22; pfam13401 444178005138 Domain of unknown function (DUF955); Region: DUF955; pfam06114 444178005139 Uncharacterized protein containing a TIR (Toll-Interleukin 1-resistance) domain [Function unknown]; Region: COG4916 444178005140 TIR domain; Region: TIR_2; pfam13676 444178005141 Bacterial SH3 domain; Region: SH3_3; pfam08239 444178005142 cystathionine beta-lyase; Provisional; Region: PRK05967 444178005143 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 444178005144 homodimer interface [polypeptide binding]; other site 444178005145 substrate-cofactor binding pocket; other site 444178005146 pyridoxal 5'-phosphate binding site [chemical binding]; other site 444178005147 catalytic residue [active] 444178005148 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 444178005149 active site 444178005150 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 444178005151 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 444178005152 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 444178005153 substrate binding pocket [chemical binding]; other site 444178005154 membrane-bound complex binding site; other site 444178005155 hinge residues; other site 444178005156 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 444178005157 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178005158 conserved gate region; other site 444178005159 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178005160 putative PBP binding loops; other site 444178005161 dimer interface [polypeptide binding]; other site 444178005162 ABC-ATPase subunit interface; other site 444178005163 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 444178005164 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178005165 dimer interface [polypeptide binding]; other site 444178005166 conserved gate region; other site 444178005167 putative PBP binding loops; other site 444178005168 ABC-ATPase subunit interface; other site 444178005169 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 444178005170 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 444178005171 Walker A/P-loop; other site 444178005172 ATP binding site [chemical binding]; other site 444178005173 Q-loop/lid; other site 444178005174 ABC transporter signature motif; other site 444178005175 Walker B; other site 444178005176 D-loop; other site 444178005177 H-loop/switch region; other site 444178005178 salicylate hydroxylase; Provisional; Region: PRK06475 444178005179 salicylate hydroxylase; Provisional; Region: PRK08163 444178005180 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391 444178005181 polyphosphate kinase; Provisional; Region: PRK05443 444178005182 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 444178005183 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 444178005184 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 444178005185 putative domain interface [polypeptide binding]; other site 444178005186 putative active site [active] 444178005187 catalytic site [active] 444178005188 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 444178005189 putative domain interface [polypeptide binding]; other site 444178005190 putative active site [active] 444178005191 catalytic site [active] 444178005192 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 444178005193 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 444178005194 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 444178005195 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 444178005196 catalytic site [active] 444178005197 putative active site [active] 444178005198 putative substrate binding site [chemical binding]; other site 444178005199 HRDC domain; Region: HRDC; pfam00570 444178005200 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 444178005201 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 444178005202 dimer interface [polypeptide binding]; other site 444178005203 anticodon binding site; other site 444178005204 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 444178005205 homodimer interface [polypeptide binding]; other site 444178005206 motif 1; other site 444178005207 active site 444178005208 motif 2; other site 444178005209 GAD domain; Region: GAD; pfam02938 444178005210 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 444178005211 active site 444178005212 motif 3; other site 444178005213 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 444178005214 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 444178005215 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 444178005216 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 444178005217 CAP-like domain; other site 444178005218 active site 444178005219 primary dimer interface [polypeptide binding]; other site 444178005220 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 444178005221 Putative arginyl-tRNA:protein arginylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG2935 444178005222 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 444178005223 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 444178005224 Predicted membrane protein/domain [Function unknown]; Region: COG1714 444178005225 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 444178005226 dimer interface [polypeptide binding]; other site 444178005227 allosteric magnesium binding site [ion binding]; other site 444178005228 active site 444178005229 aspartate-rich active site metal binding site; other site 444178005230 Schiff base residues; other site 444178005231 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 444178005232 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 444178005233 substrate binding site [chemical binding]; other site 444178005234 oxyanion hole (OAH) forming residues; other site 444178005235 trimer interface [polypeptide binding]; other site 444178005236 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 444178005237 Transcriptional regulators [Transcription]; Region: MarR; COG1846 444178005238 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 444178005239 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 444178005240 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 444178005241 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 444178005242 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 444178005243 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 444178005244 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 444178005245 dimer interface [polypeptide binding]; other site 444178005246 active site 444178005247 glycine-pyridoxal phosphate binding site [chemical binding]; other site 444178005248 folate binding site [chemical binding]; other site 444178005249 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 444178005250 ATP cone domain; Region: ATP-cone; pfam03477 444178005251 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 444178005252 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 444178005253 catalytic motif [active] 444178005254 Zn binding site [ion binding]; other site 444178005255 RibD C-terminal domain; Region: RibD_C; cl17279 444178005256 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 444178005257 Lumazine binding domain; Region: Lum_binding; pfam00677 444178005258 Lumazine binding domain; Region: Lum_binding; pfam00677 444178005259 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 444178005260 homopentamer interface [polypeptide binding]; other site 444178005261 active site 444178005262 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 444178005263 putative RNA binding site [nucleotide binding]; other site 444178005264 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; COG3808 444178005265 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 444178005266 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 444178005267 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 444178005268 Uncharacterized conserved protein [Function unknown]; Region: COG5452 444178005269 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 444178005270 putative phosphate acyltransferase; Provisional; Region: PRK05331 444178005271 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 444178005272 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 444178005273 dimer interface [polypeptide binding]; other site 444178005274 active site 444178005275 CoA binding pocket [chemical binding]; other site 444178005276 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 444178005277 IHF dimer interface [polypeptide binding]; other site 444178005278 IHF - DNA interface [nucleotide binding]; other site 444178005279 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 444178005280 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 444178005281 DNA binding residues [nucleotide binding] 444178005282 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 444178005283 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 444178005284 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 444178005285 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 444178005286 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 444178005287 SLBB domain; Region: SLBB; pfam10531 444178005288 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 444178005289 Protein of unknown function (DUF2842); Region: DUF2842; pfam11003 444178005290 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 444178005291 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 444178005292 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 444178005293 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 444178005294 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 444178005295 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 444178005296 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 444178005297 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 444178005298 oligomer interface [polypeptide binding]; other site 444178005299 putative active site [active] 444178005300 Mn binding site [ion binding]; other site 444178005301 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 444178005302 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 444178005303 23S rRNA interface [nucleotide binding]; other site 444178005304 L3 interface [polypeptide binding]; other site 444178005305 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 444178005306 CoenzymeA binding site [chemical binding]; other site 444178005307 subunit interaction site [polypeptide binding]; other site 444178005308 PHB binding site; other site 444178005309 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994 444178005310 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 444178005311 homodimer interface [polypeptide binding]; other site 444178005312 substrate-cofactor binding pocket; other site 444178005313 pyridoxal 5'-phosphate binding site [chemical binding]; other site 444178005314 catalytic residue [active] 444178005315 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 444178005316 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 444178005317 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 444178005318 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 444178005319 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 444178005320 NADH dehydrogenase subunit D; Validated; Region: PRK06075 444178005321 NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905 444178005322 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 444178005323 putative dimer interface [polypeptide binding]; other site 444178005324 [2Fe-2S] cluster binding site [ion binding]; other site 444178005325 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 444178005326 SLBB domain; Region: SLBB; pfam10531 444178005327 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 444178005328 NADH dehydrogenase subunit G; Validated; Region: PRK09130 444178005329 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 444178005330 catalytic loop [active] 444178005331 iron binding site [ion binding]; other site 444178005332 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 444178005333 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 444178005334 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 444178005335 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 444178005336 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 444178005337 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 444178005338 4Fe-4S binding domain; Region: Fer4; pfam00037 444178005339 4Fe-4S binding domain; Region: Fer4; pfam00037 444178005340 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 444178005341 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 444178005342 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 444178005343 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 444178005344 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 444178005345 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 444178005346 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 444178005347 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 444178005348 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 444178005349 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 444178005350 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 444178005351 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 444178005352 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 444178005353 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 444178005354 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 444178005355 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 444178005356 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 444178005357 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 444178005358 dimer interface [polypeptide binding]; other site 444178005359 substrate binding site [chemical binding]; other site 444178005360 metal binding site [ion binding]; metal-binding site 444178005361 Predicted secreted protein [Function unknown]; Region: COG5454 444178005362 prolyl-tRNA synthetase; Provisional; Region: PRK12325 444178005363 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 444178005364 dimer interface [polypeptide binding]; other site 444178005365 motif 1; other site 444178005366 active site 444178005367 motif 2; other site 444178005368 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 444178005369 active site 444178005370 motif 3; other site 444178005371 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 444178005372 anticodon binding site; other site 444178005373 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 444178005374 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 444178005375 FtsX-like permease family; Region: FtsX; pfam02687 444178005376 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 444178005377 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 444178005378 Walker A/P-loop; other site 444178005379 ATP binding site [chemical binding]; other site 444178005380 Q-loop/lid; other site 444178005381 ABC transporter signature motif; other site 444178005382 Walker B; other site 444178005383 D-loop; other site 444178005384 H-loop/switch region; other site 444178005385 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 444178005386 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 444178005387 putative active site [active] 444178005388 putative PHP Thumb interface [polypeptide binding]; other site 444178005389 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 444178005390 generic binding surface II; other site 444178005391 generic binding surface I; other site 444178005392 Protein of unknwon function (DUF3008); Region: DUF3008; pfam11450 444178005393 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 444178005394 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 444178005395 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 444178005396 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 444178005397 RNA binding surface [nucleotide binding]; other site 444178005398 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 444178005399 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 444178005400 Ligand Binding Site [chemical binding]; other site 444178005401 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 444178005402 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 444178005403 active site 444178005404 putative lithium-binding site [ion binding]; other site 444178005405 substrate binding site [chemical binding]; other site 444178005406 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 444178005407 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 444178005408 putative substrate translocation pore; other site 444178005409 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 444178005410 putative GSH binding site [chemical binding]; other site 444178005411 catalytic residues [active] 444178005412 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 444178005413 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 444178005414 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 444178005415 dimerization interface [polypeptide binding]; other site 444178005416 ATP binding site [chemical binding]; other site 444178005417 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 444178005418 dimerization interface [polypeptide binding]; other site 444178005419 ATP binding site [chemical binding]; other site 444178005420 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 444178005421 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 444178005422 C-terminal domain interface [polypeptide binding]; other site 444178005423 GSH binding site (G-site) [chemical binding]; other site 444178005424 dimer interface [polypeptide binding]; other site 444178005425 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 444178005426 N-terminal domain interface [polypeptide binding]; other site 444178005427 dimer interface [polypeptide binding]; other site 444178005428 substrate binding pocket (H-site) [chemical binding]; other site 444178005429 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 444178005430 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 444178005431 putative active site [active] 444178005432 catalytic triad [active] 444178005433 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 444178005434 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 444178005435 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 444178005436 ATP binding site [chemical binding]; other site 444178005437 active site 444178005438 substrate binding site [chemical binding]; other site 444178005439 Uncharacterized conserved protein [Function unknown]; Region: COG5467 444178005440 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 444178005441 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 444178005442 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 444178005443 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 444178005444 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 444178005445 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 444178005446 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 444178005447 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 444178005448 putative metal binding site [ion binding]; other site 444178005449 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 444178005450 active site 444178005451 adenylosuccinate lyase; Provisional; Region: PRK07492 444178005452 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 444178005453 tetramer interface [polypeptide binding]; other site 444178005454 active site 444178005455 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 444178005456 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 444178005457 substrate binding site [chemical binding]; other site 444178005458 hexamer interface [polypeptide binding]; other site 444178005459 metal binding site [ion binding]; metal-binding site 444178005460 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 444178005461 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 444178005462 putative acyl-acceptor binding pocket; other site 444178005463 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 444178005464 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266 444178005465 putative NAD(P) binding site [chemical binding]; other site 444178005466 structural Zn binding site [ion binding]; other site 444178005467 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501 444178005468 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 444178005469 dimer interface [polypeptide binding]; other site 444178005470 active site 444178005471 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519 444178005472 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 444178005473 active site 444178005474 acyl carrier protein; Provisional; Region: PRK06508 444178005475 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 444178005476 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 444178005477 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 444178005478 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 444178005479 active site 444178005480 catalytic residues [active] 444178005481 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 444178005482 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 444178005483 substrate binding site [chemical binding]; other site 444178005484 ATP binding site [chemical binding]; other site 444178005485 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 444178005486 Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454 444178005487 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 444178005488 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 444178005489 active site 444178005490 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 444178005491 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 444178005492 active site 444178005493 motif I; other site 444178005494 motif II; other site 444178005495 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 444178005496 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 444178005497 substrate binding pocket [chemical binding]; other site 444178005498 membrane-bound complex binding site; other site 444178005499 hinge residues; other site 444178005500 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 444178005501 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 444178005502 FMN binding site [chemical binding]; other site 444178005503 active site 444178005504 catalytic residues [active] 444178005505 substrate binding site [chemical binding]; other site 444178005506 Predicted aspartyl protease [General function prediction only]; Region: COG3577 444178005507 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 444178005508 catalytic motif [active] 444178005509 Catalytic residue [active] 444178005510 Predicted Fe-S protein [General function prediction only]; Region: COG3313 444178005511 cobalamin synthase; Reviewed; Region: cobS; PRK00235 444178005512 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 444178005513 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 444178005514 putative dimer interface [polypeptide binding]; other site 444178005515 active site pocket [active] 444178005516 putative cataytic base [active] 444178005517 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 444178005518 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 444178005519 putative DNA binding site [nucleotide binding]; other site 444178005520 putative Zn2+ binding site [ion binding]; other site 444178005521 AsnC family; Region: AsnC_trans_reg; pfam01037 444178005522 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 444178005523 putative uracil binding site [chemical binding]; other site 444178005524 putative active site [active] 444178005525 Staphylococcal nuclease homologues; Region: SNc; smart00318 444178005526 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 444178005527 Catalytic site; other site 444178005528 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 444178005529 Sel1-like repeats; Region: SEL1; smart00671 444178005530 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 444178005531 putative catalytic site [active] 444178005532 putative phosphate binding site [ion binding]; other site 444178005533 active site 444178005534 metal binding site A [ion binding]; metal-binding site 444178005535 DNA binding site [nucleotide binding] 444178005536 putative AP binding site [nucleotide binding]; other site 444178005537 putative metal binding site B [ion binding]; other site 444178005538 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 444178005539 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 444178005540 putative metal binding site [ion binding]; other site 444178005541 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 444178005542 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 444178005543 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 444178005544 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 444178005545 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 444178005546 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 444178005547 active site 444178005548 HIGH motif; other site 444178005549 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 444178005550 KMSK motif region; other site 444178005551 tRNA binding surface [nucleotide binding]; other site 444178005552 DALR anticodon binding domain; Region: DALR_1; smart00836 444178005553 anticodon binding site; other site 444178005554 Sporulation related domain; Region: SPOR; pfam05036 444178005555 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 444178005556 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 444178005557 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 444178005558 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 444178005559 twin arginine translocase protein A; Provisional; Region: tatA; PRK00720 444178005560 sec-independent translocase; Provisional; Region: PRK00708 444178005561 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 444178005562 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 444178005563 seryl-tRNA synthetase; Provisional; Region: PRK05431 444178005564 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 444178005565 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 444178005566 dimer interface [polypeptide binding]; other site 444178005567 active site 444178005568 motif 1; other site 444178005569 motif 2; other site 444178005570 motif 3; other site 444178005571 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 444178005572 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 444178005573 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 444178005574 S-adenosylmethionine binding site [chemical binding]; other site 444178005575 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 444178005576 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 444178005577 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 444178005578 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 444178005579 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 444178005580 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 444178005581 Peptidase family M23; Region: Peptidase_M23; pfam01551 444178005582 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 444178005583 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 444178005584 Walker A motif; other site 444178005585 ATP binding site [chemical binding]; other site 444178005586 Walker B motif; other site 444178005587 Preprotein translocase subunit YajC [Intracellular trafficking and secretion]; Region: YajC; COG1862 444178005588 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13023 444178005589 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 444178005590 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 444178005591 Protein export membrane protein; Region: SecD_SecF; pfam02355 444178005592 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 444178005593 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 444178005594 substrate binding pocket [chemical binding]; other site 444178005595 substrate-Mg2+ binding site; other site 444178005596 aspartate-rich region 1; other site 444178005597 aspartate-rich region 2; other site 444178005598 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 444178005599 Glucose inhibited division protein A; Region: GIDA; pfam01134 444178005600 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 444178005601 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 444178005602 Uncharacterized membrane-anchored protein [Function unknown]; Region: COG4929 444178005603 trigger factor; Provisional; Region: tig; PRK01490 444178005604 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 444178005605 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 444178005606 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 444178005607 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 444178005608 GatB domain; Region: GatB_Yqey; smart00845 444178005609 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 444178005610 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 444178005611 NADH dehydrogenase; Validated; Region: PRK08183 444178005612 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4765 444178005613 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 444178005614 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 444178005615 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 444178005616 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 444178005617 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 444178005618 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 444178005619 carboxyltransferase (CT) interaction site; other site 444178005620 biotinylation site [posttranslational modification]; other site 444178005621 Dehydroquinase class II; Region: DHquinase_II; pfam01220 444178005622 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 444178005623 trimer interface [polypeptide binding]; other site 444178005624 active site 444178005625 dimer interface [polypeptide binding]; other site 444178005626 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 444178005627 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 444178005628 catalytic residues [active] 444178005629 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 444178005630 Peptidase family M48; Region: Peptidase_M48; cl12018 444178005631 aspartate aminotransferase; Provisional; Region: PRK05764 444178005632 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 444178005633 pyridoxal 5'-phosphate binding site [chemical binding]; other site 444178005634 homodimer interface [polypeptide binding]; other site 444178005635 catalytic residue [active] 444178005636 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 444178005637 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 444178005638 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 444178005639 AMIN domain; Region: AMIN; pfam11741 444178005640 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 444178005641 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 444178005642 active site 444178005643 metal binding site [ion binding]; metal-binding site 444178005644 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 444178005645 Transglycosylase; Region: Transgly; pfam00912 444178005646 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 444178005647 peptide chain release factor 2; Provisional; Region: PRK07342 444178005648 This domain is found in peptide chain release factors; Region: PCRF; smart00937 444178005649 RF-1 domain; Region: RF-1; pfam00472 444178005650 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 444178005651 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 444178005652 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 444178005653 AsmA family; Region: AsmA; pfam05170 444178005654 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 444178005655 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 444178005656 active site 444178005657 HIGH motif; other site 444178005658 dimer interface [polypeptide binding]; other site 444178005659 KMSKS motif; other site 444178005660 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 444178005661 RNA binding surface [nucleotide binding]; other site 444178005662 Predicted molecular chaperone distantly related to HSP70-fold metalloproteases [Posttranslational modification, protein turnover, chaperones]; Region: COG2377 444178005663 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 444178005664 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 444178005665 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 444178005666 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 444178005667 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 444178005668 catalytic residue [active] 444178005669 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 444178005670 putative ABC transporter; Region: ycf24; CHL00085 444178005671 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 444178005672 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 444178005673 Walker A/P-loop; other site 444178005674 ATP binding site [chemical binding]; other site 444178005675 Q-loop/lid; other site 444178005676 ABC transporter signature motif; other site 444178005677 Walker B; other site 444178005678 D-loop; other site 444178005679 H-loop/switch region; other site 444178005680 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 444178005681 FeS assembly protein SufD; Region: sufD; TIGR01981 444178005682 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 444178005683 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 444178005684 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 444178005685 catalytic residue [active] 444178005686 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 444178005687 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 444178005688 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 444178005689 active site 444178005690 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 444178005691 ATP-NAD kinase; Region: NAD_kinase; pfam01513 444178005692 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 444178005693 helicase 45; Provisional; Region: PTZ00424 444178005694 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 444178005695 ATP binding site [chemical binding]; other site 444178005696 Mg++ binding site [ion binding]; other site 444178005697 motif III; other site 444178005698 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 444178005699 nucleotide binding region [chemical binding]; other site 444178005700 ATP-binding site [chemical binding]; other site 444178005701 FeS assembly scaffold SufA; Region: sufA_proteo; TIGR01997 444178005702 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 444178005703 metal-binding site [ion binding] 444178005704 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 444178005705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 444178005706 S-adenosylmethionine binding site [chemical binding]; other site 444178005707 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 444178005708 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3827 444178005709 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 444178005710 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 444178005711 HIGH motif; other site 444178005712 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 444178005713 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 444178005714 active site 444178005715 KMSKS motif; other site 444178005716 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 444178005717 tRNA binding surface [nucleotide binding]; other site 444178005718 anticodon binding site; other site 444178005719 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 444178005720 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 444178005721 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 444178005722 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 444178005723 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 444178005724 putative substrate binding pocket (H-site) [chemical binding]; other site 444178005725 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 444178005726 putative N-terminal domain interface [polypeptide binding]; other site 444178005727 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 444178005728 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 444178005729 substrate binding pocket [chemical binding]; other site 444178005730 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 444178005731 Walker A motif; other site 444178005732 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 444178005733 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 444178005734 GTP binding site; other site 444178005735 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 444178005736 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 444178005737 FeS/SAM binding site; other site 444178005738 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 444178005739 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 444178005740 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 444178005741 hypothetical protein; Provisional; Region: PRK06753 444178005742 fumarate hydratase; Provisional; Region: PRK15389 444178005743 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 444178005744 Fumarase C-terminus; Region: Fumerase_C; pfam05683 444178005745 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 444178005746 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 444178005747 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 444178005748 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 444178005749 ArsC family; Region: ArsC; pfam03960 444178005750 catalytic residues [active] 444178005751 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 444178005752 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 444178005753 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 444178005754 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 444178005755 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 444178005756 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 444178005757 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 444178005758 TMP-binding site; other site 444178005759 ATP-binding site [chemical binding]; other site 444178005760 DNA polymerase III subunit delta'; Validated; Region: PRK09112 444178005761 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 444178005762 DNA polymerase III subunit delta'; Validated; Region: PRK08485 444178005763 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 444178005764 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 444178005765 active site 444178005766 HIGH motif; other site 444178005767 KMSKS motif; other site 444178005768 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 444178005769 tRNA binding surface [nucleotide binding]; other site 444178005770 anticodon binding site; other site 444178005771 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 444178005772 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 444178005773 active site 444178005774 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 444178005775 putative hydrolase; Provisional; Region: PRK02113 444178005776 cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657 444178005777 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 444178005778 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 444178005779 Walker A/P-loop; other site 444178005780 ATP binding site [chemical binding]; other site 444178005781 Q-loop/lid; other site 444178005782 ABC transporter signature motif; other site 444178005783 Walker B; other site 444178005784 D-loop; other site 444178005785 H-loop/switch region; other site 444178005786 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 444178005787 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 444178005788 active site 444178005789 EamA-like transporter family; Region: EamA; pfam00892 444178005790 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 444178005791 EamA-like transporter family; Region: EamA; pfam00892 444178005792 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 444178005793 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 444178005794 motif I; other site 444178005795 active site 444178005796 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 444178005797 motif II; other site 444178005798 Chaperone required for the assembly of the mitochondrial F1-ATPase [Posttranslational modification, protein turnover, chaperones]; Region: COG5387 444178005799 glutamine synthetase; Provisional; Region: glnA; PRK09469 444178005800 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 444178005801 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 444178005802 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 444178005803 Nitrogen regulatory protein P-II; Region: P-II; smart00938 444178005804 Uncharacterized conserved protein [Function unknown]; Region: COG0062 444178005805 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 444178005806 putative substrate binding site [chemical binding]; other site 444178005807 putative ATP binding site [chemical binding]; other site 444178005808 phosphoglycolate phosphatase; Provisional; Region: PRK13222 444178005809 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 444178005810 motif II; other site 444178005811 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 444178005812 tetramer (dimer of dimers) interface [polypeptide binding]; other site 444178005813 active site 444178005814 dimer interface [polypeptide binding]; other site 444178005815 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3184 444178005816 glutathione reductase; Validated; Region: PRK06116 444178005817 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 444178005818 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 444178005819 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 444178005820 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 444178005821 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 444178005822 NAD synthetase; Provisional; Region: PRK13981 444178005823 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 444178005824 multimer interface [polypeptide binding]; other site 444178005825 active site 444178005826 catalytic triad [active] 444178005827 protein interface 1 [polypeptide binding]; other site 444178005828 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 444178005829 homodimer interface [polypeptide binding]; other site 444178005830 NAD binding pocket [chemical binding]; other site 444178005831 ATP binding pocket [chemical binding]; other site 444178005832 Mg binding site [ion binding]; other site 444178005833 active-site loop [active] 444178005834 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 444178005835 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 444178005836 active site 444178005837 HIGH motif; other site 444178005838 nucleotide binding site [chemical binding]; other site 444178005839 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 444178005840 active site 444178005841 KMSKS motif; other site 444178005842 malic enzyme; Reviewed; Region: PRK12862 444178005843 Malic enzyme, N-terminal domain; Region: malic; pfam00390 444178005844 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 444178005845 putative NAD(P) binding site [chemical binding]; other site 444178005846 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 444178005847 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 444178005848 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 444178005849 active site 444178005850 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 444178005851 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 444178005852 Permease; Region: Permease; pfam02405 444178005853 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 444178005854 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 444178005855 Walker A/P-loop; other site 444178005856 ATP binding site [chemical binding]; other site 444178005857 Q-loop/lid; other site 444178005858 ABC transporter signature motif; other site 444178005859 Walker B; other site 444178005860 D-loop; other site 444178005861 H-loop/switch region; other site 444178005862 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 444178005863 mce related protein; Region: MCE; pfam02470 444178005864 ABC-type uncharacterized transport system, auxiliary component [General function prediction only]; Region: COG3218 444178005865 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 444178005866 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 444178005867 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 444178005868 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 444178005869 catalytic loop [active] 444178005870 iron binding site [ion binding]; other site 444178005871 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 444178005872 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 444178005873 Predicted secreted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5661 444178005874 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 444178005875 dihydropteroate synthase; Region: DHPS; TIGR01496 444178005876 substrate binding pocket [chemical binding]; other site 444178005877 dimer interface [polypeptide binding]; other site 444178005878 inhibitor binding site; inhibition site 444178005879 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 444178005880 homooctamer interface [polypeptide binding]; other site 444178005881 active site 444178005882 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 444178005883 catalytic center binding site [active] 444178005884 ATP binding site [chemical binding]; other site 444178005885 Predicted membrane protein [Function unknown]; Region: COG3768 444178005886 Domain of unknown function (DUF697); Region: DUF697; cl12064 444178005887 Predicted ATPase [General function prediction only]; Region: COG3106 444178005888 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 444178005889 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 444178005890 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 444178005891 PAS domain; Region: PAS_9; pfam13426 444178005892 putative active site [active] 444178005893 heme pocket [chemical binding]; other site 444178005894 PAS domain; Region: PAS; smart00091 444178005895 PAS fold; Region: PAS_4; pfam08448 444178005896 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 444178005897 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 444178005898 dimer interface [polypeptide binding]; other site 444178005899 phosphorylation site [posttranslational modification] 444178005900 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 444178005901 ATP binding site [chemical binding]; other site 444178005902 Mg2+ binding site [ion binding]; other site 444178005903 G-X-G motif; other site 444178005904 Response regulator receiver domain; Region: Response_reg; pfam00072 444178005905 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 444178005906 active site 444178005907 phosphorylation site [posttranslational modification] 444178005908 intermolecular recognition site; other site 444178005909 dimerization interface [polypeptide binding]; other site 444178005910 Predicted flavoproteins [General function prediction only]; Region: COG2081 444178005911 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 444178005912 Beta-lactamase; Region: Beta-lactamase; pfam00144 444178005913 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 444178005914 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 444178005915 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 444178005916 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 444178005917 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 444178005918 active site 444178005919 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 444178005920 TSCPD domain; Region: TSCPD; pfam12637 444178005921 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 444178005922 nudix motif; other site 444178005923 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 444178005924 Ligand Binding Site [chemical binding]; other site 444178005925 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 444178005926 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 444178005927 putative MPT binding site; other site 444178005928 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 444178005929 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 444178005930 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 444178005931 DEAD-like helicases superfamily; Region: DEXDc; smart00487 444178005932 ATP binding site [chemical binding]; other site 444178005933 Mg++ binding site [ion binding]; other site 444178005934 motif III; other site 444178005935 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 444178005936 nucleotide binding region [chemical binding]; other site 444178005937 ATP-binding site [chemical binding]; other site 444178005938 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 444178005939 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 444178005940 dimer interface [polypeptide binding]; other site 444178005941 pyridoxal 5'-phosphate binding site [chemical binding]; other site 444178005942 catalytic residue [active] 444178005943 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 444178005944 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 444178005945 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 444178005946 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 444178005947 active site residue [active] 444178005948 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 444178005949 active site residue [active] 444178005950 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 444178005951 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 444178005952 Coenzyme A binding pocket [chemical binding]; other site 444178005953 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 444178005954 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 444178005955 metal binding site [ion binding]; metal-binding site 444178005956 active site 444178005957 I-site; other site 444178005958 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 444178005959 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 444178005960 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 444178005961 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 444178005962 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 444178005963 putative substrate translocation pore; other site 444178005964 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 444178005965 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 444178005966 putative NAD(P) binding site [chemical binding]; other site 444178005967 putative substrate binding site [chemical binding]; other site 444178005968 catalytic Zn binding site [ion binding]; other site 444178005969 structural Zn binding site [ion binding]; other site 444178005970 Tetratricopeptide repeat; Region: TPR_1; pfam00515 444178005971 Methyltransferase domain; Region: Methyltransf_23; pfam13489 444178005972 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 444178005973 S-adenosylmethionine binding site [chemical binding]; other site 444178005974 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 444178005975 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 444178005976 UDP-glucose 4-epimerase; Region: PLN02240 444178005977 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 444178005978 NAD binding site [chemical binding]; other site 444178005979 homodimer interface [polypeptide binding]; other site 444178005980 active site 444178005981 substrate binding site [chemical binding]; other site 444178005982 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 444178005983 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 444178005984 homodimer interface [polypeptide binding]; other site 444178005985 metal binding site [ion binding]; metal-binding site 444178005986 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 444178005987 homodimer interface [polypeptide binding]; other site 444178005988 active site 444178005989 putative chemical substrate binding site [chemical binding]; other site 444178005990 metal binding site [ion binding]; metal-binding site 444178005991 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 444178005992 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 444178005993 putative FMN binding site [chemical binding]; other site 444178005994 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 444178005995 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 444178005996 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 444178005997 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 444178005998 active site 444178005999 dimer interface [polypeptide binding]; other site 444178006000 motif 1; other site 444178006001 motif 2; other site 444178006002 motif 3; other site 444178006003 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 444178006004 anticodon binding site; other site 444178006005 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 444178006006 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 444178006007 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 444178006008 hypothetical protein; Validated; Region: PRK00041 444178006009 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 444178006010 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 444178006011 trimerization site [polypeptide binding]; other site 444178006012 active site 444178006013 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 444178006014 homodecamer interface [polypeptide binding]; other site 444178006015 GTP cyclohydrolase I; Provisional; Region: PLN03044 444178006016 active site 444178006017 putative catalytic site residues [active] 444178006018 zinc binding site [ion binding]; other site 444178006019 GTP-CH-I/GFRP interaction surface; other site 444178006020 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 444178006021 hypothetical protein; Provisional; Region: PRK10279 444178006022 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 444178006023 nucleophile elbow; other site 444178006024 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 444178006025 CoA-transferase family III; Region: CoA_transf_3; pfam02515 444178006026 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 444178006027 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 444178006028 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 444178006029 dimerization interface [polypeptide binding]; other site 444178006030 substrate binding pocket [chemical binding]; other site 444178006031 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 444178006032 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 444178006033 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 444178006034 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 444178006035 HlyD family secretion protein; Region: HlyD_3; pfam13437 444178006036 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 444178006037 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 444178006038 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 444178006039 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 444178006040 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 444178006041 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 444178006042 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 444178006043 active site 444178006044 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 444178006045 active site 444178006046 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 444178006047 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 444178006048 active site 444178006049 (T/H)XGH motif; other site 444178006050 DNA gyrase subunit A; Validated; Region: PRK05560 444178006051 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 444178006052 CAP-like domain; other site 444178006053 active site 444178006054 primary dimer interface [polypeptide binding]; other site 444178006055 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 444178006056 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 444178006057 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 444178006058 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 444178006059 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 444178006060 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 444178006061 Uncharacterized component of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3709 444178006062 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 444178006063 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 444178006064 DNA-binding site [nucleotide binding]; DNA binding site 444178006065 UTRA domain; Region: UTRA; pfam07702 444178006066 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 444178006067 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 444178006068 dimer interface [polypeptide binding]; other site 444178006069 ssDNA binding site [nucleotide binding]; other site 444178006070 tetramer (dimer of dimers) interface [polypeptide binding]; other site 444178006071 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 444178006072 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 444178006073 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 444178006074 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 444178006075 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 444178006076 IHF dimer interface [polypeptide binding]; other site 444178006077 IHF - DNA interface [nucleotide binding]; other site 444178006078 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 444178006079 Found in ATP-dependent protease La (LON); Region: LON; smart00464 444178006080 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 444178006081 Walker A motif; other site 444178006082 ATP binding site [chemical binding]; other site 444178006083 Walker B motif; other site 444178006084 arginine finger; other site 444178006085 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 444178006086 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 444178006087 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 444178006088 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 444178006089 Walker A motif; other site 444178006090 ATP binding site [chemical binding]; other site 444178006091 Walker B motif; other site 444178006092 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 444178006093 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 444178006094 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 444178006095 oligomer interface [polypeptide binding]; other site 444178006096 active site residues [active] 444178006097 GTPases [General function prediction only]; Region: HflX; COG2262 444178006098 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 444178006099 HflX GTPase family; Region: HflX; cd01878 444178006100 G1 box; other site 444178006101 GTP/Mg2+ binding site [chemical binding]; other site 444178006102 Switch I region; other site 444178006103 G2 box; other site 444178006104 G3 box; other site 444178006105 Switch II region; other site 444178006106 G4 box; other site 444178006107 G5 box; other site 444178006108 bacterial Hfq-like; Region: Hfq; cd01716 444178006109 hexamer interface [polypeptide binding]; other site 444178006110 Sm1 motif; other site 444178006111 RNA binding site [nucleotide binding]; other site 444178006112 Sm2 motif; other site 444178006113 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 444178006114 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 444178006115 TrkA-N domain; Region: TrkA_N; pfam02254 444178006116 TrkA-C domain; Region: TrkA_C; pfam02080 444178006117 TrkA-N domain; Region: TrkA_N; pfam02254 444178006118 TrkA-C domain; Region: TrkA_C; pfam02080 444178006119 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 444178006120 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 444178006121 active site 444178006122 phosphorylation site [posttranslational modification] 444178006123 intermolecular recognition site; other site 444178006124 dimerization interface [polypeptide binding]; other site 444178006125 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 444178006126 Walker A motif; other site 444178006127 ATP binding site [chemical binding]; other site 444178006128 Walker B motif; other site 444178006129 arginine finger; other site 444178006130 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 444178006131 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 444178006132 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 444178006133 dimerization interface [polypeptide binding]; other site 444178006134 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 444178006135 dimer interface [polypeptide binding]; other site 444178006136 phosphorylation site [posttranslational modification] 444178006137 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 444178006138 ATP binding site [chemical binding]; other site 444178006139 Mg2+ binding site [ion binding]; other site 444178006140 G-X-G motif; other site 444178006141 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 444178006142 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 444178006143 active site 444178006144 phosphorylation site [posttranslational modification] 444178006145 intermolecular recognition site; other site 444178006146 dimerization interface [polypeptide binding]; other site 444178006147 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 444178006148 Walker A motif; other site 444178006149 ATP binding site [chemical binding]; other site 444178006150 Walker B motif; other site 444178006151 arginine finger; other site 444178006152 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 444178006153 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 444178006154 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 444178006155 dimer interface [polypeptide binding]; other site 444178006156 phosphorylation site [posttranslational modification] 444178006157 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 444178006158 ATP binding site [chemical binding]; other site 444178006159 Mg2+ binding site [ion binding]; other site 444178006160 G-X-G motif; other site 444178006161 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 444178006162 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 444178006163 FMN binding site [chemical binding]; other site 444178006164 active site 444178006165 catalytic residues [active] 444178006166 substrate binding site [chemical binding]; other site 444178006167 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 444178006168 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 444178006169 substrate binding site; other site 444178006170 dimer interface; other site 444178006171 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 444178006172 homotrimer interaction site [polypeptide binding]; other site 444178006173 zinc binding site [ion binding]; other site 444178006174 CDP-binding sites; other site 444178006175 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 444178006176 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 444178006177 classical (c) SDRs; Region: SDR_c; cd05233 444178006178 NAD(P) binding site [chemical binding]; other site 444178006179 active site 444178006180 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 444178006181 putative coenzyme Q binding site [chemical binding]; other site 444178006182 lipoyl synthase; Provisional; Region: PRK05481 444178006183 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 444178006184 FeS/SAM binding site; other site 444178006185 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 444178006186 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 444178006187 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 444178006188 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 444178006189 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 444178006190 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 444178006191 E3 interaction surface; other site 444178006192 lipoyl attachment site [posttranslational modification]; other site 444178006193 e3 binding domain; Region: E3_binding; pfam02817 444178006194 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 444178006195 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 444178006196 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 444178006197 E3 interaction surface; other site 444178006198 lipoyl attachment site [posttranslational modification]; other site 444178006199 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 444178006200 alpha subunit interface [polypeptide binding]; other site 444178006201 TPP binding site [chemical binding]; other site 444178006202 heterodimer interface [polypeptide binding]; other site 444178006203 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 444178006204 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 444178006205 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 444178006206 tetramer interface [polypeptide binding]; other site 444178006207 TPP-binding site [chemical binding]; other site 444178006208 heterodimer interface [polypeptide binding]; other site 444178006209 phosphorylation loop region [posttranslational modification] 444178006210 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 444178006211 Septum formation initiator; Region: DivIC; pfam04977 444178006212 Methyltransferase domain; Region: Methyltransf_23; pfam13489 444178006213 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 444178006214 S-adenosylmethionine binding site [chemical binding]; other site 444178006215 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 444178006216 enolase; Provisional; Region: eno; PRK00077 444178006217 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 444178006218 dimer interface [polypeptide binding]; other site 444178006219 metal binding site [ion binding]; metal-binding site 444178006220 substrate binding pocket [chemical binding]; other site 444178006221 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 444178006222 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 444178006223 CTP synthetase; Validated; Region: pyrG; PRK05380 444178006224 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 444178006225 Catalytic site [active] 444178006226 active site 444178006227 UTP binding site [chemical binding]; other site 444178006228 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 444178006229 active site 444178006230 putative oxyanion hole; other site 444178006231 catalytic triad [active] 444178006232 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 444178006233 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 444178006234 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 444178006235 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 444178006236 triosephosphate isomerase; Provisional; Region: PRK14565 444178006237 substrate binding site [chemical binding]; other site 444178006238 dimer interface [polypeptide binding]; other site 444178006239 catalytic triad [active] 444178006240 SurA N-terminal domain; Region: SurA_N_3; cl07813 444178006241 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 444178006242 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 444178006243 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 444178006244 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 444178006245 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 444178006246 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 444178006247 active site 444178006248 ribulose/triose binding site [chemical binding]; other site 444178006249 phosphate binding site [ion binding]; other site 444178006250 substrate (anthranilate) binding pocket [chemical binding]; other site 444178006251 product (indole) binding pocket [chemical binding]; other site 444178006252 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 444178006253 trimer interface [polypeptide binding]; other site 444178006254 dimer interface [polypeptide binding]; other site 444178006255 putative active site [active] 444178006256 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 444178006257 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 444178006258 dimer interface [polypeptide binding]; other site 444178006259 putative functional site; other site 444178006260 putative MPT binding site; other site 444178006261 LexA repressor; Validated; Region: PRK00215 444178006262 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 444178006263 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 444178006264 Catalytic site [active] 444178006265 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 444178006266 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 444178006267 active site 444178006268 HIGH motif; other site 444178006269 nucleotide binding site [chemical binding]; other site 444178006270 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 444178006271 active site 444178006272 KMSKS motif; other site 444178006273 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 444178006274 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 444178006275 dimer interface [polypeptide binding]; other site 444178006276 active site 444178006277 citrylCoA binding site [chemical binding]; other site 444178006278 NADH binding [chemical binding]; other site 444178006279 cationic pore residues; other site 444178006280 oxalacetate/citrate binding site [chemical binding]; other site 444178006281 coenzyme A binding site [chemical binding]; other site 444178006282 catalytic triad [active] 444178006283 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 444178006284 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 444178006285 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3494 444178006286 Acyl-[acyl carrier protein]; Region: LpxA; COG1043 444178006287 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 444178006288 active site 444178006289 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 444178006290 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 444178006291 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 444178006292 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 444178006293 trimer interface [polypeptide binding]; other site 444178006294 active site 444178006295 UDP-GlcNAc binding site [chemical binding]; other site 444178006296 lipid binding site [chemical binding]; lipid-binding site 444178006297 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 444178006298 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 444178006299 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 444178006300 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 444178006301 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 444178006302 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 444178006303 Surface antigen; Region: Bac_surface_Ag; pfam01103 444178006304 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 444178006305 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 444178006306 active site 444178006307 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 444178006308 protein binding site [polypeptide binding]; other site 444178006309 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 444178006310 putative substrate binding region [chemical binding]; other site 444178006311 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 444178006312 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 444178006313 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834 444178006314 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 444178006315 catalytic residue [active] 444178006316 putative FPP diphosphate binding site; other site 444178006317 putative FPP binding hydrophobic cleft; other site 444178006318 dimer interface [polypeptide binding]; other site 444178006319 putative IPP diphosphate binding site; other site 444178006320 ribosome recycling factor; Reviewed; Region: frr; PRK00083 444178006321 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 444178006322 hinge region; other site 444178006323 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 444178006324 putative nucleotide binding site [chemical binding]; other site 444178006325 uridine monophosphate binding site [chemical binding]; other site 444178006326 homohexameric interface [polypeptide binding]; other site 444178006327 elongation factor Ts; Provisional; Region: tsf; PRK09377 444178006328 UBA/TS-N domain; Region: UBA; pfam00627 444178006329 Elongation factor TS; Region: EF_TS; pfam00889 444178006330 Elongation factor TS; Region: EF_TS; pfam00889 444178006331 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 444178006332 rRNA interaction site [nucleotide binding]; other site 444178006333 S8 interaction site; other site 444178006334 putative laminin-1 binding site; other site 444178006335 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 444178006336 Domain of unknown function (DUF1849); Region: DUF1849; pfam08904 444178006337 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 444178006338 homotrimer interaction site [polypeptide binding]; other site 444178006339 putative active site [active] 444178006340 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_3; cd08585 444178006341 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 444178006342 putative active site [active] 444178006343 catalytic site [active] 444178006344 putative metal binding site [ion binding]; other site 444178006345 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146 444178006346 Protein of unknown function, DUF482; Region: DUF482; pfam04339 444178006347 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 444178006348 HIT family signature motif; other site 444178006349 catalytic residue [active] 444178006350 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 444178006351 Clp amino terminal domain; Region: Clp_N; pfam02861 444178006352 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 444178006353 Walker A motif; other site 444178006354 ATP binding site [chemical binding]; other site 444178006355 Walker B motif; other site 444178006356 arginine finger; other site 444178006357 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 444178006358 Walker A motif; other site 444178006359 ATP binding site [chemical binding]; other site 444178006360 Walker B motif; other site 444178006361 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 444178006362 Uncharacterized conserved protein [Function unknown]; Region: COG2127 444178006363 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 444178006364 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 444178006365 Sporulation related domain; Region: SPOR; pfam05036 444178006366 Uncharacterized conserved protein [Function unknown]; Region: COG5458 444178006367 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 444178006368 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 444178006369 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 444178006370 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 444178006371 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 444178006372 Uncharacterized conserved protein [Function unknown]; Region: COG1434 444178006373 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 444178006374 putative active site [active] 444178006375 Predicted membrane protein [Function unknown]; Region: COG3503 444178006376 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 444178006377 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 444178006378 DNA binding residues [nucleotide binding] 444178006379 putative dimer interface [polypeptide binding]; other site 444178006380 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 444178006381 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 444178006382 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 444178006383 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 444178006384 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 444178006385 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3803 444178006386 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 444178006387 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 444178006388 non-specific DNA binding site [nucleotide binding]; other site 444178006389 salt bridge; other site 444178006390 sequence-specific DNA binding site [nucleotide binding]; other site 444178006391 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 444178006392 Domain of unknown function (DUF955); Region: DUF955; pfam06114 444178006393 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 444178006394 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 444178006395 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 444178006396 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 444178006397 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 444178006398 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 444178006399 carboxyltransferase (CT) interaction site; other site 444178006400 biotinylation site [posttranslational modification]; other site 444178006401 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 444178006402 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 444178006403 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 444178006404 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 444178006405 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 444178006406 glutamate racemase; Provisional; Region: PRK00865 444178006407 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 444178006408 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 444178006409 intracellular protease, PfpI family; Region: PfpI; TIGR01382 444178006410 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 444178006411 conserved cys residue [active] 444178006412 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 444178006413 isocitrate dehydrogenase; Validated; Region: PRK08299 444178006414 alkaline phosphatase; Provisional; Region: PRK10518 444178006415 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 444178006416 dimer interface [polypeptide binding]; other site 444178006417 active site 444178006418 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 444178006419 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 444178006420 motif 1; other site 444178006421 active site 444178006422 motif 2; other site 444178006423 motif 3; other site 444178006424 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 444178006425 recombinase A; Provisional; Region: recA; PRK09354 444178006426 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 444178006427 hexamer interface [polypeptide binding]; other site 444178006428 Walker A motif; other site 444178006429 ATP binding site [chemical binding]; other site 444178006430 Walker B motif; other site 444178006431 putative outer membrane lipoprotein; Provisional; Region: PRK10510 444178006432 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 444178006433 ligand binding site [chemical binding]; other site 444178006434 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 444178006435 N-acetyl-D-glucosamine binding site [chemical binding]; other site 444178006436 catalytic residue [active] 444178006437 recombination factor protein RarA; Reviewed; Region: PRK13342 444178006438 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 444178006439 Walker A motif; other site 444178006440 ATP binding site [chemical binding]; other site 444178006441 Walker B motif; other site 444178006442 arginine finger; other site 444178006443 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 444178006444 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 444178006445 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 444178006446 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 444178006447 protein binding site [polypeptide binding]; other site 444178006448 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 444178006449 protein binding site [polypeptide binding]; other site 444178006450 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 444178006451 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 444178006452 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 444178006453 alphaNTD - beta interaction site [polypeptide binding]; other site 444178006454 alphaNTD homodimer interface [polypeptide binding]; other site 444178006455 alphaNTD - beta' interaction site [polypeptide binding]; other site 444178006456 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 444178006457 30S ribosomal protein S11; Validated; Region: PRK05309 444178006458 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 444178006459 30S ribosomal protein S13; Region: bact_S13; TIGR03631 444178006460 adenylate kinase; Reviewed; Region: adk; PRK00279 444178006461 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 444178006462 AMP-binding site [chemical binding]; other site 444178006463 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 444178006464 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 444178006465 SecY translocase; Region: SecY; pfam00344 444178006466 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 444178006467 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 444178006468 23S rRNA binding site [nucleotide binding]; other site 444178006469 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 444178006470 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 444178006471 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 444178006472 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 444178006473 5S rRNA interface [nucleotide binding]; other site 444178006474 23S rRNA interface [nucleotide binding]; other site 444178006475 L5 interface [polypeptide binding]; other site 444178006476 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 444178006477 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 444178006478 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 444178006479 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 444178006480 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 444178006481 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 444178006482 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 444178006483 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 444178006484 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 444178006485 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 444178006486 RNA binding site [nucleotide binding]; other site 444178006487 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 444178006488 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 444178006489 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 444178006490 23S rRNA interface [nucleotide binding]; other site 444178006491 putative translocon interaction site; other site 444178006492 signal recognition particle (SRP54) interaction site; other site 444178006493 L23 interface [polypeptide binding]; other site 444178006494 trigger factor interaction site; other site 444178006495 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 444178006496 23S rRNA interface [nucleotide binding]; other site 444178006497 5S rRNA interface [nucleotide binding]; other site 444178006498 putative antibiotic binding site [chemical binding]; other site 444178006499 L25 interface [polypeptide binding]; other site 444178006500 L27 interface [polypeptide binding]; other site 444178006501 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 444178006502 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 444178006503 G-X-X-G motif; other site 444178006504 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 444178006505 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 444178006506 putative translocon binding site; other site 444178006507 protein-rRNA interface [nucleotide binding]; other site 444178006508 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 444178006509 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 444178006510 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 444178006511 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 444178006512 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 444178006513 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 444178006514 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 444178006515 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 444178006516 elongation factor Tu; Reviewed; Region: PRK00049 444178006517 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 444178006518 G1 box; other site 444178006519 GEF interaction site [polypeptide binding]; other site 444178006520 GTP/Mg2+ binding site [chemical binding]; other site 444178006521 Switch I region; other site 444178006522 G2 box; other site 444178006523 G3 box; other site 444178006524 Switch II region; other site 444178006525 G4 box; other site 444178006526 G5 box; other site 444178006527 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 444178006528 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 444178006529 Antibiotic Binding Site [chemical binding]; other site 444178006530 elongation factor G; Reviewed; Region: PRK00007 444178006531 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 444178006532 G1 box; other site 444178006533 putative GEF interaction site [polypeptide binding]; other site 444178006534 GTP/Mg2+ binding site [chemical binding]; other site 444178006535 Switch I region; other site 444178006536 G2 box; other site 444178006537 G3 box; other site 444178006538 Switch II region; other site 444178006539 G4 box; other site 444178006540 G5 box; other site 444178006541 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 444178006542 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 444178006543 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 444178006544 30S ribosomal protein S7; Validated; Region: PRK05302 444178006545 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 444178006546 S17 interaction site [polypeptide binding]; other site 444178006547 S8 interaction site; other site 444178006548 16S rRNA interaction site [nucleotide binding]; other site 444178006549 streptomycin interaction site [chemical binding]; other site 444178006550 23S rRNA interaction site [nucleotide binding]; other site 444178006551 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 444178006552 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 444178006553 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 444178006554 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 444178006555 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 444178006556 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 444178006557 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 444178006558 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 444178006559 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 444178006560 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 444178006561 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 444178006562 DNA binding site [nucleotide binding] 444178006563 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 444178006564 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 444178006565 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 444178006566 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 444178006567 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 444178006568 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 444178006569 RPB11 interaction site [polypeptide binding]; other site 444178006570 RPB12 interaction site [polypeptide binding]; other site 444178006571 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 444178006572 RPB1 interaction site [polypeptide binding]; other site 444178006573 RPB11 interaction site [polypeptide binding]; other site 444178006574 RPB10 interaction site [polypeptide binding]; other site 444178006575 RPB3 interaction site [polypeptide binding]; other site 444178006576 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 444178006577 L11 interface [polypeptide binding]; other site 444178006578 putative EF-Tu interaction site [polypeptide binding]; other site 444178006579 putative EF-G interaction site [polypeptide binding]; other site 444178006580 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 444178006581 23S rRNA interface [nucleotide binding]; other site 444178006582 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 444178006583 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 444178006584 mRNA/rRNA interface [nucleotide binding]; other site 444178006585 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 444178006586 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 444178006587 23S rRNA interface [nucleotide binding]; other site 444178006588 L7/L12 interface [polypeptide binding]; other site 444178006589 putative thiostrepton binding site; other site 444178006590 L25 interface [polypeptide binding]; other site 444178006591 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 444178006592 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 444178006593 putative homodimer interface [polypeptide binding]; other site 444178006594 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 444178006595 heterodimer interface [polypeptide binding]; other site 444178006596 homodimer interface [polypeptide binding]; other site 444178006597 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 444178006598 elongation factor Tu; Reviewed; Region: PRK00049 444178006599 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 444178006600 G1 box; other site 444178006601 GEF interaction site [polypeptide binding]; other site 444178006602 GTP/Mg2+ binding site [chemical binding]; other site 444178006603 Switch I region; other site 444178006604 G2 box; other site 444178006605 G3 box; other site 444178006606 Switch II region; other site 444178006607 G4 box; other site 444178006608 G5 box; other site 444178006609 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 444178006610 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 444178006611 Antibiotic Binding Site [chemical binding]; other site 444178006612 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 444178006613 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 444178006614 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 444178006615 FOG: CBS domain [General function prediction only]; Region: COG0517 444178006616 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 444178006617 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 444178006618 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 444178006619 PAS domain; Region: PAS_5; pfam07310 444178006620 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 444178006621 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 444178006622 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 444178006623 trimer interface [polypeptide binding]; other site 444178006624 putative metal binding site [ion binding]; other site 444178006625 Protein of unknown function (DUF3126); Region: DUF3126; pfam11324 444178006626 serine acetyltransferase; Provisional; Region: cysE; PRK11132 444178006627 Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971 444178006628 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 444178006629 trimer interface [polypeptide binding]; other site 444178006630 active site 444178006631 substrate binding site [chemical binding]; other site 444178006632 CoA binding site [chemical binding]; other site 444178006633 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 444178006634 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 444178006635 Uncharacterized conserved protein [Function unknown]; Region: COG1430 444178006636 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 444178006637 DNA-binding site [nucleotide binding]; DNA binding site 444178006638 RNA-binding motif; other site 444178006639 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 444178006640 DNA-binding site [nucleotide binding]; DNA binding site 444178006641 RNA-binding motif; other site 444178006642 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 444178006643 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 444178006644 dimer interface [polypeptide binding]; other site 444178006645 active site 444178006646 metal binding site [ion binding]; metal-binding site 444178006647 glutathione binding site [chemical binding]; other site 444178006648 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 444178006649 DHH family; Region: DHH; pfam01368 444178006650 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 444178006651 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 444178006652 ATP-grasp domain; Region: ATP-grasp_4; cl17255 444178006653 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 444178006654 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 444178006655 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 444178006656 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 444178006657 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 444178006658 putative active site [active] 444178006659 homoserine dehydrogenase; Provisional; Region: PRK06349 444178006660 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 444178006661 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 444178006662 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 444178006663 aminotransferase; Validated; Region: PRK09148 444178006664 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 444178006665 pyridoxal 5'-phosphate binding site [chemical binding]; other site 444178006666 homodimer interface [polypeptide binding]; other site 444178006667 catalytic residue [active] 444178006668 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3553 444178006669 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 444178006670 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 444178006671 active site 444178006672 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 444178006673 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 444178006674 MPN+ (JAMM) motif; other site 444178006675 Zinc-binding site [ion binding]; other site 444178006676 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 444178006677 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 444178006678 active site 444178006679 SAM binding site [chemical binding]; other site 444178006680 putative homodimer interface [polypeptide binding]; other site 444178006681 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 444178006682 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 444178006683 S-adenosylmethionine binding site [chemical binding]; other site 444178006684 precorrin-3B synthase; Region: CobG; TIGR02435 444178006685 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 444178006686 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 444178006687 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 444178006688 Precorrin-8X methylmutase; Region: CbiC; pfam02570 444178006689 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 444178006690 active site 444178006691 SAM binding site [chemical binding]; other site 444178006692 homodimer interface [polypeptide binding]; other site 444178006693 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 444178006694 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 444178006695 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 444178006696 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 444178006697 active site 444178006698 SAM binding site [chemical binding]; other site 444178006699 homodimer interface [polypeptide binding]; other site 444178006700 Flavin Reductases; Region: FlaRed; cl00801 444178006701 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 444178006702 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 444178006703 ligand binding site [chemical binding]; other site 444178006704 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 444178006705 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 444178006706 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 444178006707 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 444178006708 pyridoxal 5'-phosphate binding site [chemical binding]; other site 444178006709 homodimer interface [polypeptide binding]; other site 444178006710 catalytic residue [active] 444178006711 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 444178006712 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 444178006713 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 444178006714 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 444178006715 active site 444178006716 SAM binding site [chemical binding]; other site 444178006717 homodimer interface [polypeptide binding]; other site 444178006718 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 444178006719 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 444178006720 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 444178006721 active site 444178006722 SAM binding site [chemical binding]; other site 444178006723 homodimer interface [polypeptide binding]; other site 444178006724 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 444178006725 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 444178006726 tellurium resistance terB-like protein; Region: terB_like; cd07177 444178006727 metal binding site [ion binding]; metal-binding site 444178006728 hypothetical protein; Provisional; Region: PRK10621 444178006729 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 444178006730 Predicted membrane protein [Function unknown]; Region: COG2510 444178006731 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 444178006732 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 444178006733 homodimer interface [polypeptide binding]; other site 444178006734 Walker A motif; other site 444178006735 ATP binding site [chemical binding]; other site 444178006736 hydroxycobalamin binding site [chemical binding]; other site 444178006737 Walker B motif; other site 444178006738 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 444178006739 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 444178006740 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 444178006741 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 444178006742 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 444178006743 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 444178006744 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 444178006745 homotrimer interface [polypeptide binding]; other site 444178006746 Walker A motif; other site 444178006747 GTP binding site [chemical binding]; other site 444178006748 Walker B motif; other site 444178006749 Predicted integral membrane protein [Function unknown]; Region: COG5446 444178006750 cobalt transporter subunit CbtB (proposed); Region: CbtB; TIGR02459 444178006751 cobyric acid synthase; Provisional; Region: PRK00784 444178006752 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 444178006753 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 444178006754 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 444178006755 catalytic triad [active] 444178006756 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 444178006757 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 444178006758 substrate binding pocket [chemical binding]; other site 444178006759 FAD binding site [chemical binding]; other site 444178006760 catalytic base [active] 444178006761 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 444178006762 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 444178006763 Transcriptional regulator [Transcription]; Region: LysR; COG0583 444178006764 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 444178006765 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 444178006766 dimerization interface [polypeptide binding]; other site 444178006767 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 444178006768 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 444178006769 Protein export membrane protein; Region: SecD_SecF; cl14618 444178006770 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 444178006771 Protein export membrane protein; Region: SecD_SecF; pfam02355 444178006772 putative cation:proton antiport protein; Provisional; Region: PRK10669 444178006773 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 444178006774 TrkA-N domain; Region: TrkA_N; pfam02254 444178006775 Predicted integral membrane protein [Function unknown]; Region: COG0392 444178006776 sulfate transport protein; Provisional; Region: cysT; CHL00187 444178006777 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178006778 dimer interface [polypeptide binding]; other site 444178006779 conserved gate region; other site 444178006780 putative PBP binding loops; other site 444178006781 ABC-ATPase subunit interface; other site 444178006782 sulfate transport protein; Provisional; Region: cysT; CHL00187 444178006783 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178006784 dimer interface [polypeptide binding]; other site 444178006785 conserved gate region; other site 444178006786 putative PBP binding loops; other site 444178006787 ABC-ATPase subunit interface; other site 444178006788 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CysP; COG4150 444178006789 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 444178006790 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 444178006791 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 444178006792 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 444178006793 Transporter associated domain; Region: CorC_HlyC; smart01091 444178006794 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 444178006795 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 444178006796 EF-hand domain pair; Region: EF_hand_5; pfam13499 444178006797 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 444178006798 Ca2+ binding site [ion binding]; other site 444178006799 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 444178006800 Ca2+ binding site [ion binding]; other site 444178006801 Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154 444178006802 short chain dehydrogenase; Provisional; Region: PRK06198 444178006803 classical (c) SDRs; Region: SDR_c; cd05233 444178006804 NAD(P) binding site [chemical binding]; other site 444178006805 active site 444178006806 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 444178006807 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 444178006808 TM-ABC transporter signature motif; other site 444178006809 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 444178006810 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 444178006811 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 444178006812 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 444178006813 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 444178006814 Walker A/P-loop; other site 444178006815 ATP binding site [chemical binding]; other site 444178006816 Q-loop/lid; other site 444178006817 ABC transporter signature motif; other site 444178006818 Walker B; other site 444178006819 D-loop; other site 444178006820 H-loop/switch region; other site 444178006821 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 444178006822 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 444178006823 ABC-ATPase subunit interface; other site 444178006824 dimer interface [polypeptide binding]; other site 444178006825 putative PBP binding regions; other site 444178006826 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 444178006827 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 444178006828 intersubunit interface [polypeptide binding]; other site 444178006829 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 444178006830 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 444178006831 N-terminal plug; other site 444178006832 ligand-binding site [chemical binding]; other site 444178006833 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 444178006834 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 444178006835 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 444178006836 HlyD family secretion protein; Region: HlyD_3; pfam13437 444178006837 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 444178006838 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 444178006839 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 444178006840 alpha-gamma subunit interface [polypeptide binding]; other site 444178006841 beta-gamma subunit interface [polypeptide binding]; other site 444178006842 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 444178006843 alpha-beta subunit interface [polypeptide binding]; other site 444178006844 urease subunit alpha; Reviewed; Region: ureC; PRK13309 444178006845 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 444178006846 subunit interactions [polypeptide binding]; other site 444178006847 active site 444178006848 flap region; other site 444178006849 urease accessory protein UreE; Provisional; Region: ureE; PRK14711 444178006850 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 444178006851 dimer interface [polypeptide binding]; other site 444178006852 catalytic residues [active] 444178006853 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 444178006854 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 444178006855 ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266 444178006856 cobalt transport protein CbiM; Validated; Region: PRK06265 444178006857 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 444178006858 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 444178006859 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 444178006860 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 444178006861 Walker A/P-loop; other site 444178006862 ATP binding site [chemical binding]; other site 444178006863 Q-loop/lid; other site 444178006864 ABC transporter signature motif; other site 444178006865 Walker B; other site 444178006866 D-loop; other site 444178006867 H-loop/switch region; other site 444178006868 camphor resistance protein CrcB; Provisional; Region: ccrB; PRK01636 444178006869 Uncharacterized conserved protein [Function unknown]; Region: COG3439 444178006870 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 444178006871 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 444178006872 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 444178006873 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 444178006874 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 444178006875 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 444178006876 nudix motif; other site 444178006877 BA14K-like protein; Region: BA14K; pfam07886 444178006878 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 444178006879 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 444178006880 pyridoxal 5'-phosphate binding site [chemical binding]; other site 444178006881 homodimer interface [polypeptide binding]; other site 444178006882 catalytic residue [active] 444178006883 ketol-acid reductoisomerase; Provisional; Region: PRK05479 444178006884 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 444178006885 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 444178006886 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 444178006887 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 444178006888 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 444178006889 potassium uptake protein; Region: kup; TIGR00794 444178006890 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 444178006891 active site 444178006892 hydrophilic channel; other site 444178006893 dimerization interface [polypeptide binding]; other site 444178006894 catalytic residues [active] 444178006895 active site lid [active] 444178006896 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 444178006897 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 444178006898 AAA domain; Region: AAA_30; pfam13604 444178006899 Family description; Region: UvrD_C_2; pfam13538 444178006900 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 444178006901 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 444178006902 putative valine binding site [chemical binding]; other site 444178006903 dimer interface [polypeptide binding]; other site 444178006904 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 444178006905 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 444178006906 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 444178006907 PYR/PP interface [polypeptide binding]; other site 444178006908 dimer interface [polypeptide binding]; other site 444178006909 TPP binding site [chemical binding]; other site 444178006910 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 444178006911 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 444178006912 TPP-binding site [chemical binding]; other site 444178006913 dimer interface [polypeptide binding]; other site 444178006914 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 444178006915 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 444178006916 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 444178006917 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 444178006918 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 444178006919 motif II; other site 444178006920 Predicted flavoproteins [General function prediction only]; Region: COG2081 444178006921 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 444178006922 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 444178006923 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 444178006924 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 444178006925 protein binding site [polypeptide binding]; other site 444178006926 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 444178006927 protein binding site [polypeptide binding]; other site 444178006928 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 444178006929 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 444178006930 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 444178006931 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 444178006932 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 444178006933 HflK protein; Region: hflK; TIGR01933 444178006934 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 444178006935 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 444178006936 folate binding site [chemical binding]; other site 444178006937 NADP+ binding site [chemical binding]; other site 444178006938 thymidylate synthase; Reviewed; Region: thyA; PRK01827 444178006939 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 444178006940 dimerization interface [polypeptide binding]; other site 444178006941 active site 444178006942 Protein of unknown function (DUF2853); Region: DUF2853; pfam11015 444178006943 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 444178006944 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 444178006945 putative substrate translocation pore; other site 444178006946 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 444178006947 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 444178006948 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 444178006949 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814 444178006950 Domain of unknown function (DUF4169); Region: DUF4169; pfam13770 444178006951 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 444178006952 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 444178006953 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 444178006954 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 444178006955 FAD binding domain; Region: FAD_binding_4; pfam01565 444178006956 Uncharacterized conserved protein [Function unknown]; Region: COG4702 444178006957 serine/threonine protein kinase; Provisional; Region: PRK09188 444178006958 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 444178006959 active site 444178006960 ATP binding site [chemical binding]; other site 444178006961 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 444178006962 Part of AAA domain; Region: AAA_19; pfam13245 444178006963 Family description; Region: UvrD_C_2; pfam13538 444178006964 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 444178006965 CreA protein; Region: CreA; pfam05981 444178006966 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 444178006967 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 444178006968 Cu(I) binding site [ion binding]; other site 444178006969 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 444178006970 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 444178006971 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 444178006972 active site 444178006973 Uncharacterized conserved protein [Function unknown]; Region: COG5587 444178006974 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 444178006975 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 444178006976 nucleotide binding pocket [chemical binding]; other site 444178006977 K-X-D-G motif; other site 444178006978 catalytic site [active] 444178006979 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 444178006980 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 444178006981 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 444178006982 Dimer interface [polypeptide binding]; other site 444178006983 BRCT sequence motif; other site 444178006984 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 444178006985 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 444178006986 Walker A/P-loop; other site 444178006987 ATP binding site [chemical binding]; other site 444178006988 Q-loop/lid; other site 444178006989 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 444178006990 ABC transporter signature motif; other site 444178006991 Walker B; other site 444178006992 D-loop; other site 444178006993 H-loop/switch region; other site 444178006994 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 444178006995 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 444178006996 binding surface 444178006997 TPR motif; other site 444178006998 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 444178006999 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 444178007000 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 444178007001 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 444178007002 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 444178007003 cell division protein FtsZ; Validated; Region: PRK09330 444178007004 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 444178007005 nucleotide binding site [chemical binding]; other site 444178007006 SulA interaction site; other site 444178007007 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 444178007008 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 444178007009 Cell division protein FtsA; Region: FtsA; smart00842 444178007010 Cell division protein FtsA; Region: FtsA; pfam14450 444178007011 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 444178007012 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 444178007013 Cell division protein FtsQ; Region: FtsQ; pfam03799 444178007014 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 444178007015 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 444178007016 ATP-grasp domain; Region: ATP-grasp_4; cl17255 444178007017 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 444178007018 FAD binding domain; Region: FAD_binding_4; pfam01565 444178007019 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 444178007020 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 444178007021 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 444178007022 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 444178007023 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 444178007024 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 444178007025 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 444178007026 active site 444178007027 homodimer interface [polypeptide binding]; other site 444178007028 cell division protein FtsW; Region: ftsW; TIGR02614 444178007029 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 444178007030 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 444178007031 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 444178007032 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 444178007033 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 444178007034 Mg++ binding site [ion binding]; other site 444178007035 putative catalytic motif [active] 444178007036 putative substrate binding site [chemical binding]; other site 444178007037 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093 444178007038 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 444178007039 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 444178007040 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 444178007041 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 444178007042 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 444178007043 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 444178007044 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 444178007045 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 444178007046 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 444178007047 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 444178007048 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 444178007049 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 444178007050 MraW methylase family; Region: Methyltransf_5; cl17771 444178007051 manganese transport protein MntH; Reviewed; Region: PRK00701 444178007052 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 444178007053 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 444178007054 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 444178007055 N-acetyl-D-glucosamine binding site [chemical binding]; other site 444178007056 catalytic residue [active] 444178007057 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 444178007058 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 444178007059 amidase catalytic site [active] 444178007060 Zn binding residues [ion binding]; other site 444178007061 substrate binding site [chemical binding]; other site 444178007062 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 444178007063 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 444178007064 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 444178007065 putative metal binding site [ion binding]; other site 444178007066 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 444178007067 HSP70 interaction site [polypeptide binding]; other site 444178007068 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 444178007069 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 444178007070 active site 444178007071 Transglycosylase SLT domain; Region: SLT_2; pfam13406 444178007072 murein hydrolase B; Provisional; Region: PRK10760; cl17906 444178007073 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 444178007074 Predicted permeases [General function prediction only]; Region: COG0679 444178007075 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 444178007076 FAD binding site [chemical binding]; other site 444178007077 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 444178007078 dimerization interface [polypeptide binding]; other site 444178007079 putative DNA binding site [nucleotide binding]; other site 444178007080 putative Zn2+ binding site [ion binding]; other site 444178007081 Methyltransferase domain; Region: Methyltransf_23; pfam13489 444178007082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 444178007083 S-adenosylmethionine binding site [chemical binding]; other site 444178007084 Uncharacterized conserved protein [Function unknown]; Region: COG5586 444178007085 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 444178007086 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 444178007087 S-adenosylmethionine binding site [chemical binding]; other site 444178007088 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 444178007089 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 444178007090 Walker A/P-loop; other site 444178007091 ATP binding site [chemical binding]; other site 444178007092 Q-loop/lid; other site 444178007093 ABC transporter signature motif; other site 444178007094 Walker B; other site 444178007095 D-loop; other site 444178007096 H-loop/switch region; other site 444178007097 ABC transporter; Region: ABC_tran_2; pfam12848 444178007098 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 444178007099 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 444178007100 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 444178007101 PGAP1-like protein; Region: PGAP1; pfam07819 444178007102 Protein of unknown function (DUF1498); Region: DUF1498; pfam07385 444178007103 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 444178007104 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 444178007105 [2Fe-2S] cluster binding site [ion binding]; other site 444178007106 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 444178007107 putative alpha subunit interface [polypeptide binding]; other site 444178007108 putative active site [active] 444178007109 putative substrate binding site [chemical binding]; other site 444178007110 Fe binding site [ion binding]; other site 444178007111 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 444178007112 Isochorismatase family; Region: Isochorismatase; pfam00857 444178007113 catalytic triad [active] 444178007114 metal binding site [ion binding]; metal-binding site 444178007115 conserved cis-peptide bond; other site 444178007116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899 444178007117 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 444178007118 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 444178007119 active site 444178007120 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 444178007121 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 444178007122 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 444178007123 DNA binding site [nucleotide binding] 444178007124 Int/Topo IB signature motif; other site 444178007125 active site 444178007126 catalytic residues [active] 444178007127 Uncharacterized conserved protein [Function unknown]; Region: COG2968 444178007128 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 444178007129 hypothetical protein; Provisional; Region: PRK05170 444178007130 Uncharacterized conserved protein [Function unknown]; Region: COG5453 444178007131 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 444178007132 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 444178007133 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 444178007134 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 444178007135 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 444178007136 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 444178007137 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 444178007138 DNA binding residues [nucleotide binding] 444178007139 DNA primase; Validated; Region: dnaG; PRK05667 444178007140 CHC2 zinc finger; Region: zf-CHC2; pfam01807 444178007141 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 444178007142 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 444178007143 active site 444178007144 metal binding site [ion binding]; metal-binding site 444178007145 interdomain interaction site; other site 444178007146 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 444178007147 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 444178007148 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 444178007149 PhoU domain; Region: PhoU; pfam01895 444178007150 PhoU domain; Region: PhoU; pfam01895 444178007151 Uncharacterized conserved protein [Function unknown]; Region: COG1610 444178007152 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 444178007153 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 444178007154 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 444178007155 catalytic site [active] 444178007156 subunit interface [polypeptide binding]; other site 444178007157 Predicted membrane protein [Function unknown]; Region: COG5395 444178007158 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 444178007159 LytTr DNA-binding domain; Region: LytTR; pfam04397 444178007160 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 444178007161 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 444178007162 ATP-grasp domain; Region: ATP-grasp_4; cl17255 444178007163 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 444178007164 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 444178007165 ATP-grasp domain; Region: ATP-grasp_4; cl17255 444178007166 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 444178007167 IMP binding site; other site 444178007168 dimer interface [polypeptide binding]; other site 444178007169 partial ornithine binding site; other site 444178007170 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 444178007171 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 444178007172 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 444178007173 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 444178007174 nudix motif; other site 444178007175 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 444178007176 DNA-binding site [nucleotide binding]; DNA binding site 444178007177 RNA-binding motif; other site 444178007178 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 444178007179 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 444178007180 putative C-terminal domain interface [polypeptide binding]; other site 444178007181 putative GSH binding site (G-site) [chemical binding]; other site 444178007182 putative dimer interface [polypeptide binding]; other site 444178007183 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 444178007184 N-terminal domain interface [polypeptide binding]; other site 444178007185 dimer interface [polypeptide binding]; other site 444178007186 substrate binding pocket (H-site) [chemical binding]; other site 444178007187 aspartate aminotransferase; Provisional; Region: PRK05764 444178007188 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 444178007189 pyridoxal 5'-phosphate binding site [chemical binding]; other site 444178007190 homodimer interface [polypeptide binding]; other site 444178007191 catalytic residue [active] 444178007192 Transcriptional regulator [Transcription]; Region: LysR; COG0583 444178007193 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 444178007194 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 444178007195 putative effector binding pocket; other site 444178007196 dimerization interface [polypeptide binding]; other site 444178007197 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 444178007198 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 444178007199 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 444178007200 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 444178007201 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 444178007202 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 444178007203 putative DNA binding site [nucleotide binding]; other site 444178007204 putative Zn2+ binding site [ion binding]; other site 444178007205 AsnC family; Region: AsnC_trans_reg; pfam01037 444178007206 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 444178007207 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 444178007208 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 444178007209 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 444178007210 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 444178007211 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 444178007212 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 444178007213 EamA-like transporter family; Region: EamA; pfam00892 444178007214 EamA-like transporter family; Region: EamA; pfam00892 444178007215 Protein of unknown function, DUF486; Region: DUF486; cl01236 444178007216 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921 444178007217 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 444178007218 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 444178007219 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 444178007220 Bacterial SH3 domain; Region: SH3_3; pfam08239 444178007221 excinuclease ABC subunit B; Provisional; Region: PRK05298 444178007222 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 444178007223 ATP binding site [chemical binding]; other site 444178007224 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 444178007225 nucleotide binding region [chemical binding]; other site 444178007226 ATP-binding site [chemical binding]; other site 444178007227 Ultra-violet resistance protein B; Region: UvrB; pfam12344 444178007228 UvrB/uvrC motif; Region: UVR; pfam02151 444178007229 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 444178007230 N-acetyl-D-glucosamine binding site [chemical binding]; other site 444178007231 catalytic residue [active] 444178007232 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 444178007233 DNA-binding site [nucleotide binding]; DNA binding site 444178007234 RNA-binding motif; other site 444178007235 BA14K-like protein; Region: BA14K; pfam07886 444178007236 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 444178007237 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 444178007238 MarR family; Region: MarR_2; pfam12802 444178007239 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 444178007240 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 444178007241 active site 444178007242 phosphorylation site [posttranslational modification] 444178007243 intermolecular recognition site; other site 444178007244 dimerization interface [polypeptide binding]; other site 444178007245 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 444178007246 DNA binding site [nucleotide binding] 444178007247 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 444178007248 dimer interface [polypeptide binding]; other site 444178007249 phosphorylation site [posttranslational modification] 444178007250 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 444178007251 ATP binding site [chemical binding]; other site 444178007252 Mg2+ binding site [ion binding]; other site 444178007253 G-X-G motif; other site 444178007254 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 444178007255 dimer interface [polypeptide binding]; other site 444178007256 putative tRNA-binding site [nucleotide binding]; other site 444178007257 Uncharacterized conserved protein [Function unknown]; Region: COG5465 444178007258 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 444178007259 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 444178007260 Uncharacterized conserved protein [Function unknown]; Region: COG1565 444178007261 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 444178007262 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 444178007263 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 444178007264 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 444178007265 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 444178007266 active site 444178007267 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 444178007268 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 444178007269 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 444178007270 active site 444178007271 HerA helicase [Replication, recombination, and repair]; Region: COG0433 444178007272 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 444178007273 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 444178007274 5S rRNA interface [nucleotide binding]; other site 444178007275 CTC domain interface [polypeptide binding]; other site 444178007276 L16 interface [polypeptide binding]; other site 444178007277 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 444178007278 putative active site [active] 444178007279 catalytic residue [active] 444178007280 GTP-binding protein YchF; Reviewed; Region: PRK09601 444178007281 YchF GTPase; Region: YchF; cd01900 444178007282 G1 box; other site 444178007283 GTP/Mg2+ binding site [chemical binding]; other site 444178007284 Switch I region; other site 444178007285 G2 box; other site 444178007286 Switch II region; other site 444178007287 G3 box; other site 444178007288 G4 box; other site 444178007289 G5 box; other site 444178007290 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 444178007291 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 444178007292 putative active site [active] 444178007293 putative catalytic site [active] 444178007294 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 444178007295 active site 444178007296 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 444178007297 cytochrome b; Provisional; Region: CYTB; MTH00191 444178007298 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 444178007299 Qi binding site; other site 444178007300 intrachain domain interface; other site 444178007301 interchain domain interface [polypeptide binding]; other site 444178007302 heme bH binding site [chemical binding]; other site 444178007303 heme bL binding site [chemical binding]; other site 444178007304 Qo binding site; other site 444178007305 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 444178007306 interchain domain interface [polypeptide binding]; other site 444178007307 intrachain domain interface; other site 444178007308 Qi binding site; other site 444178007309 Qo binding site; other site 444178007310 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 444178007311 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 444178007312 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 444178007313 [2Fe-2S] cluster binding site [ion binding]; other site 444178007314 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 444178007315 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 444178007316 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 444178007317 Walker A/P-loop; other site 444178007318 ATP binding site [chemical binding]; other site 444178007319 Q-loop/lid; other site 444178007320 ABC transporter signature motif; other site 444178007321 Walker B; other site 444178007322 D-loop; other site 444178007323 H-loop/switch region; other site 444178007324 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 444178007325 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 444178007326 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 444178007327 Walker A/P-loop; other site 444178007328 ATP binding site [chemical binding]; other site 444178007329 Q-loop/lid; other site 444178007330 ABC transporter signature motif; other site 444178007331 Walker B; other site 444178007332 D-loop; other site 444178007333 H-loop/switch region; other site 444178007334 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 444178007335 Purine nucleoside permease [Nucleotide transport and metabolism]; Region: NUP; COG5042 444178007336 Coproporphyrinogen III oxidase [Coenzyme metabolism]; Region: HemF; COG0408 444178007337 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752 444178007338 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 444178007339 Coenzyme A binding pocket [chemical binding]; other site 444178007340 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 444178007341 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 444178007342 active site 444178007343 NTP binding site [chemical binding]; other site 444178007344 metal binding triad [ion binding]; metal-binding site 444178007345 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 444178007346 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 444178007347 putative active site [active] 444178007348 putative CoA binding site [chemical binding]; other site 444178007349 nudix motif; other site 444178007350 metal binding site [ion binding]; metal-binding site 444178007351 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816 444178007352 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 444178007353 MoxR-like ATPases [General function prediction only]; Region: COG0714 444178007354 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 444178007355 ATP binding site [chemical binding]; other site 444178007356 Walker B motif; other site 444178007357 arginine finger; other site 444178007358 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 444178007359 Protein of unknown function DUF58; Region: DUF58; pfam01882 444178007360 N-terminal double-transmembrane domain; Region: two_anch; TIGR02226 444178007361 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 444178007362 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 444178007363 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 444178007364 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 444178007365 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 444178007366 Coenzyme A binding pocket [chemical binding]; other site 444178007367 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 444178007368 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 444178007369 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 444178007370 putative dimer interface [polypeptide binding]; other site 444178007371 N-terminal domain interface [polypeptide binding]; other site 444178007372 putative substrate binding pocket (H-site) [chemical binding]; other site 444178007373 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 444178007374 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 444178007375 nudix motif; other site 444178007376 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 444178007377 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 444178007378 active site 444178007379 metal binding site [ion binding]; metal-binding site 444178007380 2-isopropylmalate synthase; Validated; Region: PRK03739 444178007381 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 444178007382 active site 444178007383 catalytic residues [active] 444178007384 metal binding site [ion binding]; metal-binding site 444178007385 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 444178007386 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 444178007387 Cation efflux family; Region: Cation_efflux; pfam01545 444178007388 anthranilate synthase; Provisional; Region: PRK13566 444178007389 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 444178007390 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 444178007391 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 444178007392 glutamine binding [chemical binding]; other site 444178007393 catalytic triad [active] 444178007394 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 444178007395 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 444178007396 putative DNA binding site [nucleotide binding]; other site 444178007397 putative Zn2+ binding site [ion binding]; other site 444178007398 AsnC family; Region: AsnC_trans_reg; pfam01037 444178007399 Transcriptional regulators [Transcription]; Region: MarR; COG1846 444178007400 MarR family; Region: MarR_2; pfam12802 444178007401 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 444178007402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 444178007403 putative substrate translocation pore; other site 444178007404 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG5459 444178007405 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5345 444178007406 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 444178007407 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 444178007408 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178007409 dimer interface [polypeptide binding]; other site 444178007410 conserved gate region; other site 444178007411 putative PBP binding loops; other site 444178007412 ABC-ATPase subunit interface; other site 444178007413 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 444178007414 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 444178007415 Walker A/P-loop; other site 444178007416 ATP binding site [chemical binding]; other site 444178007417 Q-loop/lid; other site 444178007418 ABC transporter signature motif; other site 444178007419 Walker B; other site 444178007420 D-loop; other site 444178007421 H-loop/switch region; other site 444178007422 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 444178007423 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 444178007424 Walker A/P-loop; other site 444178007425 ATP binding site [chemical binding]; other site 444178007426 Q-loop/lid; other site 444178007427 ABC transporter signature motif; other site 444178007428 Walker B; other site 444178007429 D-loop; other site 444178007430 H-loop/switch region; other site 444178007431 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 444178007432 dipeptide transporter; Provisional; Region: PRK10913 444178007433 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 444178007434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178007435 dimer interface [polypeptide binding]; other site 444178007436 conserved gate region; other site 444178007437 putative PBP binding loops; other site 444178007438 ABC-ATPase subunit interface; other site 444178007439 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 444178007440 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178007441 dimer interface [polypeptide binding]; other site 444178007442 conserved gate region; other site 444178007443 putative PBP binding loops; other site 444178007444 ABC-ATPase subunit interface; other site 444178007445 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 444178007446 dimerization interface [polypeptide binding]; other site 444178007447 putative DNA binding site [nucleotide binding]; other site 444178007448 putative Zn2+ binding site [ion binding]; other site 444178007449 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 444178007450 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 444178007451 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 444178007452 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 444178007453 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 444178007454 Ligand Binding Site [chemical binding]; other site 444178007455 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 444178007456 Predicted acetyltransferase [General function prediction only]; Region: COG2388 444178007457 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 444178007458 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5400 444178007459 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5385 444178007460 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 444178007461 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 444178007462 active site 444178007463 phosphorylation site [posttranslational modification] 444178007464 intermolecular recognition site; other site 444178007465 dimerization interface [polypeptide binding]; other site 444178007466 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 444178007467 DNA binding site [nucleotide binding] 444178007468 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 444178007469 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 444178007470 inhibitor-cofactor binding pocket; inhibition site 444178007471 pyridoxal 5'-phosphate binding site [chemical binding]; other site 444178007472 catalytic residue [active] 444178007473 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 444178007474 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 444178007475 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 444178007476 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 444178007477 PAS domain; Region: PAS_8; pfam13188 444178007478 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 444178007479 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 444178007480 putative active site [active] 444178007481 heme pocket [chemical binding]; other site 444178007482 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 444178007483 dimer interface [polypeptide binding]; other site 444178007484 phosphorylation site [posttranslational modification] 444178007485 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 444178007486 ATP binding site [chemical binding]; other site 444178007487 Mg2+ binding site [ion binding]; other site 444178007488 G-X-G motif; other site 444178007489 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 444178007490 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 444178007491 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 444178007492 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 444178007493 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 444178007494 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 444178007495 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 444178007496 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 444178007497 non-specific DNA binding site [nucleotide binding]; other site 444178007498 salt bridge; other site 444178007499 sequence-specific DNA binding site [nucleotide binding]; other site 444178007500 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 444178007501 Domain of unknown function (DUF955); Region: DUF955; pfam06114 444178007502 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 444178007503 isocitrate lyase; Provisional; Region: PRK15063 444178007504 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 444178007505 tetramer interface [polypeptide binding]; other site 444178007506 active site 444178007507 Mg2+/Mn2+ binding site [ion binding]; other site 444178007508 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 444178007509 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 444178007510 NAD binding site [chemical binding]; other site 444178007511 substrate binding site [chemical binding]; other site 444178007512 homotetramer interface [polypeptide binding]; other site 444178007513 homodimer interface [polypeptide binding]; other site 444178007514 active site 444178007515 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 444178007516 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 444178007517 NAD binding site [chemical binding]; other site 444178007518 substrate binding site [chemical binding]; other site 444178007519 homotetramer interface [polypeptide binding]; other site 444178007520 homodimer interface [polypeptide binding]; other site 444178007521 active site 444178007522 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 444178007523 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 444178007524 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 444178007525 active site 444178007526 nucleophile elbow; other site 444178007527 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 444178007528 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 444178007529 DAK2 domain; Region: Dak2; cl03685 444178007530 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 444178007531 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 444178007532 DNA binding residues [nucleotide binding] 444178007533 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 444178007534 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 444178007535 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 444178007536 DAK2 domain; Region: Dak2; pfam02734 444178007537 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 444178007538 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 444178007539 short chain dehydrogenase; Provisional; Region: PRK06841 444178007540 classical (c) SDRs; Region: SDR_c; cd05233 444178007541 NAD(P) binding site [chemical binding]; other site 444178007542 active site 444178007543 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 444178007544 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 444178007545 putative ligand binding site [chemical binding]; other site 444178007546 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 444178007547 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 444178007548 TM-ABC transporter signature motif; other site 444178007549 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 444178007550 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 444178007551 Walker A/P-loop; other site 444178007552 ATP binding site [chemical binding]; other site 444178007553 Q-loop/lid; other site 444178007554 ABC transporter signature motif; other site 444178007555 Walker B; other site 444178007556 D-loop; other site 444178007557 H-loop/switch region; other site 444178007558 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 444178007559 Uncharacterized conserved protein [Function unknown]; Region: COG5591 444178007560 choline dehydrogenase; Validated; Region: PRK02106 444178007561 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 444178007562 Transcriptional regulator [Transcription]; Region: IclR; COG1414 444178007563 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 444178007564 Bacterial transcriptional regulator; Region: IclR; pfam01614 444178007565 succinic semialdehyde dehydrogenase; Region: PLN02278 444178007566 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 444178007567 tetramerization interface [polypeptide binding]; other site 444178007568 NAD(P) binding site [chemical binding]; other site 444178007569 catalytic residues [active] 444178007570 Predicted membrane protein [Function unknown]; Region: COG1238 444178007571 Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495 444178007572 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 444178007573 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 444178007574 active site 444178007575 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 444178007576 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 444178007577 helix-hairpin-helix signature motif; other site 444178007578 substrate binding pocket [chemical binding]; other site 444178007579 active site 444178007580 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 444178007581 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 444178007582 active site 444178007583 HIGH motif; other site 444178007584 nucleotide binding site [chemical binding]; other site 444178007585 active site 444178007586 KMSKS motif; other site 444178007587 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 444178007588 active site 444178007589 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 444178007590 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 444178007591 Coenzyme A binding pocket [chemical binding]; other site 444178007592 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 444178007593 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 444178007594 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 444178007595 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 444178007596 DNA binding residues [nucleotide binding] 444178007597 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 444178007598 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 444178007599 RNA binding surface [nucleotide binding]; other site 444178007600 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 444178007601 active site 444178007602 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 444178007603 metal binding site 2 [ion binding]; metal-binding site 444178007604 putative DNA binding helix; other site 444178007605 metal binding site 1 [ion binding]; metal-binding site 444178007606 dimer interface [polypeptide binding]; other site 444178007607 structural Zn2+ binding site [ion binding]; other site 444178007608 PAS fold; Region: PAS_4; pfam08448 444178007609 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 444178007610 HWE histidine kinase; Region: HWE_HK; pfam07536 444178007611 two-component response regulator; Provisional; Region: PRK09191 444178007612 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 444178007613 active site 444178007614 phosphorylation site [posttranslational modification] 444178007615 intermolecular recognition site; other site 444178007616 dimerization interface [polypeptide binding]; other site 444178007617 RNA polymerase sigma factor; Provisional; Region: PRK12516 444178007618 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 444178007619 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 444178007620 DNA binding residues [nucleotide binding] 444178007621 CHASE3 domain; Region: CHASE3; pfam05227 444178007622 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 444178007623 Histidine kinase; Region: HisKA_2; pfam07568 444178007624 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 444178007625 ATP binding site [chemical binding]; other site 444178007626 Mg2+ binding site [ion binding]; other site 444178007627 G-X-G motif; other site 444178007628 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 444178007629 PRC-barrel domain; Region: PRC; pfam05239 444178007630 PRC-barrel domain; Region: PRC; pfam05239 444178007631 tonB-system energizer ExbB; Region: exbB; TIGR02797 444178007632 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 444178007633 TonB system transport protein ExbD, group 1; Region: ExbD_1; TIGR02803 444178007634 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 444178007635 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 444178007636 Predicted periplasmic protein [Function unknown]; Region: COG3698 444178007637 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 444178007638 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 444178007639 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 444178007640 Walker A/P-loop; other site 444178007641 ATP binding site [chemical binding]; other site 444178007642 Q-loop/lid; other site 444178007643 ABC transporter signature motif; other site 444178007644 Walker B; other site 444178007645 D-loop; other site 444178007646 H-loop/switch region; other site 444178007647 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 444178007648 FtsX-like permease family; Region: FtsX; pfam02687 444178007649 macrolide transporter subunit MacA; Provisional; Region: PRK11578 444178007650 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 444178007651 HlyD family secretion protein; Region: HlyD_3; pfam13437 444178007652 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 444178007653 trimer interface [polypeptide binding]; other site 444178007654 active site 444178007655 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 444178007656 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 444178007657 dimerization interface [polypeptide binding]; other site 444178007658 putative DNA binding site [nucleotide binding]; other site 444178007659 putative Zn2+ binding site [ion binding]; other site 444178007660 AsnC family; Region: AsnC_trans_reg; pfam01037 444178007661 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 444178007662 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 444178007663 putative active site [active] 444178007664 putative dimer interface [polypeptide binding]; other site 444178007665 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 444178007666 diiron binding motif [ion binding]; other site 444178007667 Uncharacterized conserved protein [Function unknown]; Region: COG1633 444178007668 CCC1-related protein family; Region: CCC1_like_1; cd02437 444178007669 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 444178007670 metabolite-proton symporter; Region: 2A0106; TIGR00883 444178007671 putative substrate translocation pore; other site 444178007672 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 444178007673 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 444178007674 GDP-binding site [chemical binding]; other site 444178007675 ACT binding site; other site 444178007676 IMP binding site; other site 444178007677 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 444178007678 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 444178007679 Coenzyme A binding pocket [chemical binding]; other site 444178007680 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 444178007681 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 444178007682 ligand binding site [chemical binding]; other site 444178007683 NAD binding site [chemical binding]; other site 444178007684 dimerization interface [polypeptide binding]; other site 444178007685 catalytic site [active] 444178007686 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 444178007687 putative L-serine binding site [chemical binding]; other site 444178007688 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 444178007689 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 444178007690 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 444178007691 catalytic residue [active] 444178007692 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 444178007693 Sodium Bile acid symporter family; Region: SBF; pfam01758 444178007694 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 444178007695 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 444178007696 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 444178007697 active site 444178007698 substrate binding site [chemical binding]; other site 444178007699 metal binding site [ion binding]; metal-binding site 444178007700 FtsH Extracellular; Region: FtsH_ext; pfam06480 444178007701 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 444178007702 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 444178007703 Walker A motif; other site 444178007704 ATP binding site [chemical binding]; other site 444178007705 Walker B motif; other site 444178007706 arginine finger; other site 444178007707 Peptidase family M41; Region: Peptidase_M41; pfam01434 444178007708 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 444178007709 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 444178007710 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 444178007711 Tetratricopeptide repeat; Region: TPR_6; pfam13174 444178007712 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 444178007713 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 444178007714 ligand binding site [chemical binding]; other site 444178007715 translocation protein TolB; Provisional; Region: tolB; PRK05137 444178007716 TolB amino-terminal domain; Region: TolB_N; pfam04052 444178007717 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 444178007718 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 444178007719 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 444178007720 TolR protein; Region: tolR; TIGR02801 444178007721 TolQ protein; Region: tolQ; TIGR02796 444178007722 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 444178007723 active site 444178007724 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 444178007725 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 444178007726 Walker A motif; other site 444178007727 ATP binding site [chemical binding]; other site 444178007728 Walker B motif; other site 444178007729 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 444178007730 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 444178007731 RuvA N terminal domain; Region: RuvA_N; pfam01330 444178007732 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 444178007733 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 444178007734 active site 444178007735 putative DNA-binding cleft [nucleotide binding]; other site 444178007736 dimer interface [polypeptide binding]; other site 444178007737 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5317 444178007738 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4645 444178007739 Acyltransferase family; Region: Acyl_transf_3; pfam01757 444178007740 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 444178007741 active site 444178007742 thiamine phosphate binding site [chemical binding]; other site 444178007743 pyrophosphate binding site [ion binding]; other site 444178007744 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 444178007745 Sel1-like repeats; Region: SEL1; smart00671 444178007746 Sel1-like repeats; Region: SEL1; smart00671 444178007747 elongation factor P; Validated; Region: PRK00529 444178007748 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 444178007749 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 444178007750 RNA binding site [nucleotide binding]; other site 444178007751 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 444178007752 RNA binding site [nucleotide binding]; other site 444178007753 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 444178007754 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 444178007755 active site 444178007756 dimerization interface [polypeptide binding]; other site 444178007757 hypothetical protein; Validated; Region: PRK09039 444178007758 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 444178007759 ligand binding site [chemical binding]; other site 444178007760 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 444178007761 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 444178007762 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 444178007763 Walker A/P-loop; other site 444178007764 ATP binding site [chemical binding]; other site 444178007765 Q-loop/lid; other site 444178007766 ABC transporter signature motif; other site 444178007767 Walker B; other site 444178007768 D-loop; other site 444178007769 H-loop/switch region; other site 444178007770 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 444178007771 hypothetical protein; Validated; Region: PRK00110 444178007772 Transcriptional regulators [Transcription]; Region: GntR; COG1802 444178007773 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 444178007774 DNA-binding site [nucleotide binding]; DNA binding site 444178007775 FCD domain; Region: FCD; pfam07729 444178007776 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 444178007777 Uncharacterized conserved protein [Function unknown]; Region: COG3543 444178007778 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 444178007779 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 444178007780 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 444178007781 putative active site [active] 444178007782 metal binding site [ion binding]; metal-binding site 444178007783 homodimer binding site [polypeptide binding]; other site 444178007784 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 444178007785 Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division, chromosome partitioning]; Region: zapA; COG3027 444178007786 Domain of unknown function (DUF4164); Region: DUF4164; pfam13747 444178007787 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 444178007788 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 444178007789 TPP-binding site [chemical binding]; other site 444178007790 dimer interface [polypeptide binding]; other site 444178007791 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 444178007792 PYR/PP interface [polypeptide binding]; other site 444178007793 dimer interface [polypeptide binding]; other site 444178007794 TPP binding site [chemical binding]; other site 444178007795 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 444178007796 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 444178007797 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 444178007798 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 444178007799 Phosphoglycerate kinase; Region: PGK; pfam00162 444178007800 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 444178007801 substrate binding site [chemical binding]; other site 444178007802 hinge regions; other site 444178007803 ADP binding site [chemical binding]; other site 444178007804 catalytic site [active] 444178007805 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 444178007806 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 444178007807 acyl-activating enzyme (AAE) consensus motif; other site 444178007808 putative AMP binding site [chemical binding]; other site 444178007809 putative active site [active] 444178007810 putative CoA binding site [chemical binding]; other site 444178007811 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 444178007812 Predicted transcriptional regulator [Transcription]; Region: COG2378 444178007813 HTH domain; Region: HTH_11; pfam08279 444178007814 WYL domain; Region: WYL; pfam13280 444178007815 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 444178007816 CoenzymeA binding site [chemical binding]; other site 444178007817 subunit interaction site [polypeptide binding]; other site 444178007818 PHB binding site; other site 444178007819 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 444178007820 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820 444178007821 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 444178007822 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 444178007823 NAD(P) binding site [chemical binding]; other site 444178007824 Uncharacterized small protein containing a coiled-coil domain [Function unknown]; Region: COG5509 444178007825 putative MFS family transporter protein; Provisional; Region: PRK03633 444178007826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 444178007827 putative substrate translocation pore; other site 444178007828 Uncharacterized small protein [Function unknown]; Region: COG5570 444178007829 Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481 444178007830 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 444178007831 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 444178007832 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 444178007833 NAD binding site [chemical binding]; other site 444178007834 ATP-grasp domain; Region: ATP-grasp; pfam02222 444178007835 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 444178007836 TPR repeat; Region: TPR_11; pfam13414 444178007837 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 444178007838 TPR motif; other site 444178007839 binding surface 444178007840 pyruvate kinase; Provisional; Region: PRK06247 444178007841 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 444178007842 domain interfaces; other site 444178007843 active site 444178007844 Predicted integral membrane protein [Function unknown]; Region: COG5480 444178007845 Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931 444178007846 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3750 444178007847 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 444178007848 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 444178007849 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 444178007850 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 444178007851 Thiamine pyrophosphokinase; Region: TPK; cd07995 444178007852 active site 444178007853 dimerization interface [polypeptide binding]; other site 444178007854 thiamine binding site [chemical binding]; other site 444178007855 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 444178007856 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 444178007857 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 444178007858 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 444178007859 Walker A/P-loop; other site 444178007860 ATP binding site [chemical binding]; other site 444178007861 Q-loop/lid; other site 444178007862 ABC transporter signature motif; other site 444178007863 Walker B; other site 444178007864 D-loop; other site 444178007865 H-loop/switch region; other site 444178007866 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 444178007867 Peptidase family M48; Region: Peptidase_M48; pfam01435 444178007868 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 444178007869 MOSC domain; Region: MOSC; pfam03473 444178007870 3-alpha domain; Region: 3-alpha; pfam03475 444178007871 RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500 444178007872 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 444178007873 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 444178007874 DNA binding residues [nucleotide binding] 444178007875 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 444178007876 Ferredoxin [Energy production and conversion]; Region: COG1146 444178007877 4Fe-4S binding domain; Region: Fer4; pfam00037 444178007878 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 444178007879 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 444178007880 RNA binding surface [nucleotide binding]; other site 444178007881 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 444178007882 ATP binding site [chemical binding]; other site 444178007883 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 444178007884 putative Mg++ binding site [ion binding]; other site 444178007885 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 444178007886 nucleotide binding region [chemical binding]; other site 444178007887 ATP-binding site [chemical binding]; other site 444178007888 putative acyltransferase; Provisional; Region: PRK05790 444178007889 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 444178007890 dimer interface [polypeptide binding]; other site 444178007891 active site 444178007892 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 444178007893 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 444178007894 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 444178007895 Transglycosylase; Region: Transgly; pfam00912 444178007896 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 444178007897 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 444178007898 substrate binding pocket [chemical binding]; other site 444178007899 chain length determination region; other site 444178007900 substrate-Mg2+ binding site; other site 444178007901 catalytic residues [active] 444178007902 aspartate-rich region 1; other site 444178007903 active site lid residues [active] 444178007904 aspartate-rich region 2; other site 444178007905 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 444178007906 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 444178007907 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 444178007908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 444178007909 Major Facilitator Superfamily; Region: MFS_1; pfam07690 444178007910 putative substrate translocation pore; other site 444178007911 pyruvate carboxylase; Reviewed; Region: PRK12999 444178007912 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 444178007913 ATP-grasp domain; Region: ATP-grasp_4; cl17255 444178007914 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 444178007915 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 444178007916 active site 444178007917 catalytic residues [active] 444178007918 metal binding site [ion binding]; metal-binding site 444178007919 homodimer binding site [polypeptide binding]; other site 444178007920 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 444178007921 carboxyltransferase (CT) interaction site; other site 444178007922 biotinylation site [posttranslational modification]; other site 444178007923 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 444178007924 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 444178007925 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 444178007926 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 444178007927 dimerization interface [polypeptide binding]; other site 444178007928 ligand binding site [chemical binding]; other site 444178007929 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 444178007930 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 444178007931 Walker A/P-loop; other site 444178007932 ATP binding site [chemical binding]; other site 444178007933 Q-loop/lid; other site 444178007934 ABC transporter signature motif; other site 444178007935 Walker B; other site 444178007936 D-loop; other site 444178007937 H-loop/switch region; other site 444178007938 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 444178007939 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 444178007940 Walker A/P-loop; other site 444178007941 ATP binding site [chemical binding]; other site 444178007942 Q-loop/lid; other site 444178007943 ABC transporter signature motif; other site 444178007944 Walker B; other site 444178007945 D-loop; other site 444178007946 H-loop/switch region; other site 444178007947 Uncharacterized conserved protein [Function unknown]; Region: COG3743 444178007948 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 444178007949 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 444178007950 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 444178007951 TM-ABC transporter signature motif; other site 444178007952 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 444178007953 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 444178007954 TM-ABC transporter signature motif; other site 444178007955 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 444178007956 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 444178007957 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 444178007958 Transcriptional regulators [Transcription]; Region: FadR; COG2186 444178007959 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 444178007960 DNA-binding site [nucleotide binding]; DNA binding site 444178007961 FCD domain; Region: FCD; pfam07729 444178007962 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 444178007963 MarR family; Region: MarR; pfam01047 444178007964 F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]; Region: AtpC; COG0355 444178007965 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 444178007966 gamma subunit interface [polypeptide binding]; other site 444178007967 epsilon subunit interface [polypeptide binding]; other site 444178007968 LBP interface [polypeptide binding]; other site 444178007969 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 444178007970 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 444178007971 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 444178007972 alpha subunit interaction interface [polypeptide binding]; other site 444178007973 Walker A motif; other site 444178007974 ATP binding site [chemical binding]; other site 444178007975 Walker B motif; other site 444178007976 inhibitor binding site; inhibition site 444178007977 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 444178007978 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 444178007979 core domain interface [polypeptide binding]; other site 444178007980 delta subunit interface [polypeptide binding]; other site 444178007981 epsilon subunit interface [polypeptide binding]; other site 444178007982 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 444178007983 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 444178007984 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 444178007985 beta subunit interaction interface [polypeptide binding]; other site 444178007986 Walker A motif; other site 444178007987 ATP binding site [chemical binding]; other site 444178007988 Walker B motif; other site 444178007989 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 444178007990 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 444178007991 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 444178007992 primosome assembly protein PriA; Validated; Region: PRK05580 444178007993 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 444178007994 ATP binding site [chemical binding]; other site 444178007995 putative Mg++ binding site [ion binding]; other site 444178007996 helicase superfamily c-terminal domain; Region: HELICc; smart00490 444178007997 nucleotide binding region [chemical binding]; other site 444178007998 ATP-binding site [chemical binding]; other site 444178007999 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 444178008000 active site 444178008001 intersubunit interactions; other site 444178008002 catalytic residue [active] 444178008003 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5468 444178008004 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 444178008005 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 444178008006 HIGH motif; other site 444178008007 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 444178008008 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 444178008009 active site 444178008010 KMSKS motif; other site 444178008011 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 444178008012 tRNA binding surface [nucleotide binding]; other site 444178008013 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 444178008014 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 444178008015 catalytic residue [active] 444178008016 Predicted membrane protein [Function unknown]; Region: COG1289 444178008017 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 444178008018 Usg protein, probable subunit of phosphoribosylanthranilate isomerase [Amino acid transport and metabolism]; Region: COG5425 444178008019 acetyl-CoA synthetase; Provisional; Region: PRK00174 444178008020 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 444178008021 active site 444178008022 CoA binding site [chemical binding]; other site 444178008023 acyl-activating enzyme (AAE) consensus motif; other site 444178008024 AMP binding site [chemical binding]; other site 444178008025 acetate binding site [chemical binding]; other site 444178008026 Uncharacterized conserved small protein [Function unknown]; Region: COG5508 444178008027 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 444178008028 heat shock protein HtpX; Provisional; Region: PRK01345 444178008029 NusB family; Region: NusB; pfam01029 444178008030 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 444178008031 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 444178008032 S-adenosylmethionine binding site [chemical binding]; other site 444178008033 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5360 444178008034 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 444178008035 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 444178008036 purine monophosphate binding site [chemical binding]; other site 444178008037 dimer interface [polypeptide binding]; other site 444178008038 putative catalytic residues [active] 444178008039 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 444178008040 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 444178008041 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 444178008042 Predicted membrane protein [Function unknown]; Region: COG3762 444178008043 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 444178008044 Repair protein; Region: Repair_PSII; pfam04536 444178008045 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 444178008046 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 444178008047 chorismate mutase; Provisional; Region: PRK09239 444178008048 signal recognition particle protein; Provisional; Region: PRK10867 444178008049 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 444178008050 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 444178008051 P loop; other site 444178008052 GTP binding site [chemical binding]; other site 444178008053 Signal peptide binding domain; Region: SRP_SPB; pfam02978 444178008054 lytic murein transglycosylase; Region: MltB_2; TIGR02283 444178008055 murein hydrolase B; Provisional; Region: PRK10760; cl17906 444178008056 pyridoxamine kinase; Validated; Region: PRK05756 444178008057 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 444178008058 dimer interface [polypeptide binding]; other site 444178008059 pyridoxal binding site [chemical binding]; other site 444178008060 ATP binding site [chemical binding]; other site 444178008061 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 444178008062 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 444178008063 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 444178008064 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 444178008065 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 444178008066 tetrameric interface [polypeptide binding]; other site 444178008067 NAD binding site [chemical binding]; other site 444178008068 catalytic residues [active] 444178008069 Transcriptional regulator [Transcription]; Region: LysR; COG0583 444178008070 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 444178008071 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 444178008072 dimerization interface [polypeptide binding]; other site 444178008073 Predicted membrane protein [Function unknown]; Region: COG3619 444178008074 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 444178008075 putative active site [active] 444178008076 Ap4A binding site [chemical binding]; other site 444178008077 nudix motif; other site 444178008078 putative metal binding site [ion binding]; other site 444178008079 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 444178008080 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 444178008081 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 444178008082 protein binding site [polypeptide binding]; other site 444178008083 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 444178008084 Catalytic dyad [active] 444178008085 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 444178008086 Peptidase family M23; Region: Peptidase_M23; pfam01551 444178008087 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 444178008088 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 444178008089 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 444178008090 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 444178008091 active site 444178008092 (T/H)XGH motif; other site 444178008093 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 444178008094 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 444178008095 putative catalytic cysteine [active] 444178008096 gamma-glutamyl kinase; Provisional; Region: PRK05429 444178008097 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 444178008098 nucleotide binding site [chemical binding]; other site 444178008099 homotetrameric interface [polypeptide binding]; other site 444178008100 putative phosphate binding site [ion binding]; other site 444178008101 putative allosteric binding site; other site 444178008102 PUA domain; Region: PUA; pfam01472 444178008103 GTPase CgtA; Reviewed; Region: obgE; PRK12299 444178008104 GTP1/OBG; Region: GTP1_OBG; pfam01018 444178008105 Obg GTPase; Region: Obg; cd01898 444178008106 G1 box; other site 444178008107 GTP/Mg2+ binding site [chemical binding]; other site 444178008108 Switch I region; other site 444178008109 G2 box; other site 444178008110 G3 box; other site 444178008111 Switch II region; other site 444178008112 G4 box; other site 444178008113 G5 box; other site 444178008114 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 444178008115 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 444178008116 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 444178008117 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 444178008118 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 444178008119 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 444178008120 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 444178008121 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 444178008122 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 444178008123 Integrase core domain; Region: rve; pfam00665 444178008124 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 444178008125 Peptidase family M23; Region: Peptidase_M23; pfam01551 444178008126 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 444178008127 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 444178008128 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 444178008129 Clp amino terminal domain; Region: Clp_N; pfam02861 444178008130 Clp amino terminal domain; Region: Clp_N; pfam02861 444178008131 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 444178008132 Walker A motif; other site 444178008133 ATP binding site [chemical binding]; other site 444178008134 Walker B motif; other site 444178008135 arginine finger; other site 444178008136 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 444178008137 Walker A motif; other site 444178008138 ATP binding site [chemical binding]; other site 444178008139 Walker B motif; other site 444178008140 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 444178008141 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 444178008142 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 444178008143 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 444178008144 S-adenosylmethionine binding site [chemical binding]; other site 444178008145 peptide chain release factor 1; Validated; Region: prfA; PRK00591 444178008146 This domain is found in peptide chain release factors; Region: PCRF; smart00937 444178008147 RF-1 domain; Region: RF-1; pfam00472 444178008148 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 444178008149 GAF domain; Region: GAF; pfam01590 444178008150 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 444178008151 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 444178008152 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 444178008153 aspartate kinase; Reviewed; Region: PRK06635 444178008154 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 444178008155 putative nucleotide binding site [chemical binding]; other site 444178008156 putative catalytic residues [active] 444178008157 putative Mg ion binding site [ion binding]; other site 444178008158 putative aspartate binding site [chemical binding]; other site 444178008159 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 444178008160 putative allosteric regulatory site; other site 444178008161 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 444178008162 putative allosteric regulatory residue; other site 444178008163 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 444178008164 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 444178008165 S-adenosylmethionine binding site [chemical binding]; other site 444178008166 EamA-like transporter family; Region: EamA; pfam00892 444178008167 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5319 444178008168 Predicted amidohydrolase [General function prediction only]; Region: COG0388 444178008169 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 444178008170 putative active site [active] 444178008171 catalytic triad [active] 444178008172 dimer interface [polypeptide binding]; other site 444178008173 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 444178008174 GSH binding site [chemical binding]; other site 444178008175 catalytic residues [active] 444178008176 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 444178008177 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 444178008178 active site 444178008179 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 444178008180 Methyltransferase domain; Region: Methyltransf_11; pfam08241 444178008181 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 444178008182 putative substrate translocation pore; other site 444178008183 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 444178008184 putative metal binding site [ion binding]; other site 444178008185 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 444178008186 HemY protein N-terminus; Region: HemY_N; pfam07219 444178008187 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223 444178008188 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 444178008189 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 444178008190 active site 444178008191 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 444178008192 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 444178008193 domain interfaces; other site 444178008194 active site 444178008195 UGMP family protein; Validated; Region: PRK09604 444178008196 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 444178008197 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 444178008198 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 444178008199 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 444178008200 YCII-related domain; Region: YCII; cl00999 444178008201 Uncharacterized conserved protein [Function unknown]; Region: COG2947 444178008202 Predicted methyltransferase [General function prediction only]; Region: COG3897 444178008203 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 444178008204 S-adenosylmethionine binding site [chemical binding]; other site 444178008205 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 444178008206 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 444178008207 DNA-binding site [nucleotide binding]; DNA binding site 444178008208 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 444178008209 pyridoxal 5'-phosphate binding site [chemical binding]; other site 444178008210 homodimer interface [polypeptide binding]; other site 444178008211 catalytic residue [active] 444178008212 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 444178008213 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 444178008214 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 444178008215 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 444178008216 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 444178008217 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 444178008218 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 444178008219 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 444178008220 active site 444178008221 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 444178008222 catalytic triad [active] 444178008223 dimer interface [polypeptide binding]; other site 444178008224 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333 444178008225 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 444178008226 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 444178008227 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 444178008228 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 444178008229 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 444178008230 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 444178008231 L-aspartate oxidase; Provisional; Region: PRK06175 444178008232 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 444178008233 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 444178008234 putative SdhC subunit interface [polypeptide binding]; other site 444178008235 putative proximal heme binding site [chemical binding]; other site 444178008236 putative Iron-sulfur protein interface [polypeptide binding]; other site 444178008237 putative proximal quinone binding site; other site 444178008238 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 444178008239 Iron-sulfur protein interface; other site 444178008240 proximal quinone binding site [chemical binding]; other site 444178008241 SdhD (CybS) interface [polypeptide binding]; other site 444178008242 proximal heme binding site [chemical binding]; other site 444178008243 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 444178008244 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 444178008245 Coenzyme A binding pocket [chemical binding]; other site 444178008246 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 444178008247 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 444178008248 substrate binding site [chemical binding]; other site 444178008249 ligand binding site [chemical binding]; other site 444178008250 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 444178008251 Cytosine/uracil/thiamine/allantoin permeases [Nucleotide transport and metabolism / Coenzyme metabolism]; Region: FUI1; COG1953 444178008252 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 444178008253 Na binding site [ion binding]; other site 444178008254 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 444178008255 NIPSNAP; Region: NIPSNAP; pfam07978 444178008256 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 444178008257 dimerization interface [polypeptide binding]; other site 444178008258 putative DNA binding site [nucleotide binding]; other site 444178008259 putative Zn2+ binding site [ion binding]; other site 444178008260 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 444178008261 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 444178008262 RimM N-terminal domain; Region: RimM; pfam01782 444178008263 PRC-barrel domain; Region: PRC; pfam05239 444178008264 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 444178008265 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 444178008266 active site 444178008267 DNA binding site [nucleotide binding] 444178008268 Int/Topo IB signature motif; other site 444178008269 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 444178008270 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 444178008271 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 444178008272 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 444178008273 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 444178008274 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 444178008275 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 444178008276 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 444178008277 E3 interaction surface; other site 444178008278 lipoyl attachment site [posttranslational modification]; other site 444178008279 e3 binding domain; Region: E3_binding; pfam02817 444178008280 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 444178008281 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 444178008282 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 444178008283 TPP-binding site [chemical binding]; other site 444178008284 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 444178008285 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 444178008286 CoA binding domain; Region: CoA_binding; smart00881 444178008287 CoA-ligase; Region: Ligase_CoA; pfam00549 444178008288 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 444178008289 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 444178008290 CoA-ligase; Region: Ligase_CoA; pfam00549 444178008291 malate dehydrogenase; Reviewed; Region: PRK06223 444178008292 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 444178008293 NAD(P) binding site [chemical binding]; other site 444178008294 dimer interface [polypeptide binding]; other site 444178008295 tetramer (dimer of dimers) interface [polypeptide binding]; other site 444178008296 substrate binding site [chemical binding]; other site 444178008297 Predicted ATPase [General function prediction only]; Region: COG1485 444178008298 Protease inhibitor Inh; Region: Inh; pfam02974 444178008299 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 444178008300 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 444178008301 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 444178008302 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 444178008303 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 444178008304 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 444178008305 FeS/SAM binding site; other site 444178008306 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 444178008307 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 444178008308 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 444178008309 intracellular septation protein A; Reviewed; Region: PRK00259 444178008310 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 444178008311 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 444178008312 active site 444178008313 8-oxo-dGMP binding site [chemical binding]; other site 444178008314 nudix motif; other site 444178008315 metal binding site [ion binding]; metal-binding site 444178008316 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 444178008317 Coenzyme A binding pocket [chemical binding]; other site 444178008318 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 444178008319 heterotetramer interface [polypeptide binding]; other site 444178008320 active site pocket [active] 444178008321 cleavage site 444178008322 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 444178008323 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 444178008324 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 444178008325 DEAD/DEAH box helicase; Region: DEAD; pfam00270 444178008326 ATP binding site [chemical binding]; other site 444178008327 putative Mg++ binding site [ion binding]; other site 444178008328 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 444178008329 SEC-C motif; Region: SEC-C; pfam02810 444178008330 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 444178008331 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 444178008332 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 444178008333 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 444178008334 Sulfatase; Region: Sulfatase; pfam00884 444178008335 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 444178008336 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 444178008337 substrate binding pocket [chemical binding]; other site 444178008338 membrane-bound complex binding site; other site 444178008339 hinge residues; other site 444178008340 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 444178008341 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178008342 dimer interface [polypeptide binding]; other site 444178008343 conserved gate region; other site 444178008344 putative PBP binding loops; other site 444178008345 ABC-ATPase subunit interface; other site 444178008346 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178008347 dimer interface [polypeptide binding]; other site 444178008348 conserved gate region; other site 444178008349 putative PBP binding loops; other site 444178008350 ABC-ATPase subunit interface; other site 444178008351 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 444178008352 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 444178008353 Walker A/P-loop; other site 444178008354 ATP binding site [chemical binding]; other site 444178008355 Q-loop/lid; other site 444178008356 ABC transporter signature motif; other site 444178008357 Walker B; other site 444178008358 D-loop; other site 444178008359 H-loop/switch region; other site 444178008360 agmatinase; Region: agmatinase; TIGR01230 444178008361 Agmatinase and related proteins; Region: Agmatinase_like_1; cd11589 444178008362 oligomer interface [polypeptide binding]; other site 444178008363 active site 444178008364 Mn binding site [ion binding]; other site 444178008365 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 444178008366 Aspartase; Region: Aspartase; cd01357 444178008367 active sites [active] 444178008368 tetramer interface [polypeptide binding]; other site 444178008369 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 444178008370 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 444178008371 Walker A/P-loop; other site 444178008372 ATP binding site [chemical binding]; other site 444178008373 Q-loop/lid; other site 444178008374 ABC transporter signature motif; other site 444178008375 Walker B; other site 444178008376 D-loop; other site 444178008377 H-loop/switch region; other site 444178008378 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 444178008379 active site 444178008380 homotetramer interface [polypeptide binding]; other site 444178008381 homodimer interface [polypeptide binding]; other site 444178008382 Transcriptional regulators [Transcription]; Region: GntR; COG1802 444178008383 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 444178008384 DNA-binding site [nucleotide binding]; DNA binding site 444178008385 FCD domain; Region: FCD; pfam07729 444178008386 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 444178008387 active site 444178008388 homotetramer interface [polypeptide binding]; other site 444178008389 homodimer interface [polypeptide binding]; other site 444178008390 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 444178008391 D-galactonate transporter; Region: 2A0114; TIGR00893 444178008392 putative substrate translocation pore; other site 444178008393 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 444178008394 Ligand Binding Site [chemical binding]; other site 444178008395 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 444178008396 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 444178008397 dimer interface [polypeptide binding]; other site 444178008398 pyridoxal 5'-phosphate binding site [chemical binding]; other site 444178008399 catalytic residue [active] 444178008400 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 444178008401 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 444178008402 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 444178008403 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 444178008404 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 444178008405 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 444178008406 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 444178008407 Ligand binding site [chemical binding]; other site 444178008408 Electron transfer flavoprotein domain; Region: ETF; pfam01012 444178008409 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 444178008410 Ligand Binding Site [chemical binding]; other site 444178008411 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 444178008412 active site 444178008413 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 444178008414 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 444178008415 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 444178008416 Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588 444178008417 short chain dehydrogenase; Provisional; Region: PRK05993 444178008418 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 444178008419 NADP binding site [chemical binding]; other site 444178008420 active site 444178008421 steroid binding site; other site 444178008422 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 444178008423 hypothetical protein; Validated; Region: PRK00124 444178008424 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 444178008425 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 444178008426 catalytic residues [active] 444178008427 argininosuccinate lyase; Provisional; Region: PRK00855 444178008428 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 444178008429 active sites [active] 444178008430 tetramer interface [polypeptide binding]; other site 444178008431 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 444178008432 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 444178008433 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 444178008434 active site 444178008435 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 444178008436 substrate binding site [chemical binding]; other site 444178008437 catalytic residues [active] 444178008438 dimer interface [polypeptide binding]; other site 444178008439 TIGR02302 family protein; Region: aProt_lowcomp 444178008440 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 444178008441 active site 444178008442 Methyltransferase domain; Region: Methyltransf_23; pfam13489 444178008443 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 444178008444 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 444178008445 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 444178008446 pyridoxal 5'-phosphate binding site [chemical binding]; other site 444178008447 homodimer interface [polypeptide binding]; other site 444178008448 catalytic residue [active] 444178008449 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 444178008450 prephenate dehydrogenase; Validated; Region: PRK08507 444178008451 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4093 444178008452 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 444178008453 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 444178008454 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 444178008455 putative active site pocket [active] 444178008456 dimerization interface [polypeptide binding]; other site 444178008457 putative catalytic residue [active] 444178008458 YGGT family; Region: YGGT; pfam02325 444178008459 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 444178008460 dimer interface [polypeptide binding]; other site 444178008461 substrate binding site [chemical binding]; other site 444178008462 metal binding sites [ion binding]; metal-binding site 444178008463 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 444178008464 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 444178008465 putative acyl-acceptor binding pocket; other site 444178008466 Uncharacterized conserved protein [Function unknown]; Region: COG1434 444178008467 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 444178008468 putative active site [active] 444178008469 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 444178008470 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 444178008471 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 444178008472 Walker A/P-loop; other site 444178008473 ATP binding site [chemical binding]; other site 444178008474 Q-loop/lid; other site 444178008475 ABC transporter signature motif; other site 444178008476 Walker B; other site 444178008477 D-loop; other site 444178008478 H-loop/switch region; other site 444178008479 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 444178008480 amphipathic channel; other site 444178008481 Asn-Pro-Ala signature motifs; other site 444178008482 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 444178008483 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 444178008484 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 444178008485 putative catalytic site [active] 444178008486 putative phosphate binding site [ion binding]; other site 444178008487 active site 444178008488 metal binding site A [ion binding]; metal-binding site 444178008489 DNA binding site [nucleotide binding] 444178008490 putative AP binding site [nucleotide binding]; other site 444178008491 putative metal binding site B [ion binding]; other site 444178008492 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 444178008493 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 444178008494 ligand binding site [chemical binding]; other site 444178008495 flexible hinge region; other site 444178008496 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 444178008497 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 444178008498 active site 444178008499 phosphorylation site [posttranslational modification] 444178008500 intermolecular recognition site; other site 444178008501 dimerization interface [polypeptide binding]; other site 444178008502 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 444178008503 DNA binding site [nucleotide binding] 444178008504 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 444178008505 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 444178008506 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 444178008507 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 444178008508 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 444178008509 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 444178008510 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 444178008511 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 444178008512 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 444178008513 DNA binding residues [nucleotide binding] 444178008514 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 444178008515 dimer interface [polypeptide binding]; other site 444178008516 putative metal binding site [ion binding]; other site 444178008517 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 444178008518 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 444178008519 metal-binding site [ion binding] 444178008520 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 444178008521 Soluble P-type ATPase [General function prediction only]; Region: COG4087 444178008522 Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase) [Coenzyme metabolism]; Region: CobT; COG4547 444178008523 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 444178008524 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 444178008525 metal ion-dependent adhesion site (MIDAS); other site 444178008526 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 444178008527 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 444178008528 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 444178008529 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 444178008530 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 444178008531 HSP70 interaction site [polypeptide binding]; other site 444178008532 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 444178008533 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 444178008534 Domain of unknown function DUF21; Region: DUF21; pfam01595 444178008535 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 444178008536 Transporter associated domain; Region: CorC_HlyC; smart01091 444178008537 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 444178008538 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 444178008539 active site 444178008540 dimer interface [polypeptide binding]; other site 444178008541 metal binding site [ion binding]; metal-binding site 444178008542 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 444178008543 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 444178008544 ADP binding site [chemical binding]; other site 444178008545 magnesium binding site [ion binding]; other site 444178008546 putative shikimate binding site; other site 444178008547 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 444178008548 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 444178008549 active site 444178008550 DNA binding site [nucleotide binding] 444178008551 Int/Topo IB signature motif; other site 444178008552 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 444178008553 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 444178008554 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 444178008555 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 444178008556 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 444178008557 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 444178008558 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 444178008559 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 444178008560 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 444178008561 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 444178008562 metal binding site [ion binding]; metal-binding site 444178008563 putative dimer interface [polypeptide binding]; other site 444178008564 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 444178008565 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 444178008566 NAD(P) binding site [chemical binding]; other site 444178008567 active site 444178008568 Uncharacterized conserved protein [Function unknown]; Region: COG3791 444178008569 Domain of unknown function (DUF4354); Region: DUF4354; pfam14263 444178008570 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 444178008571 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 444178008572 NAD(P) binding site [chemical binding]; other site 444178008573 active site 444178008574 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 444178008575 Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118 444178008576 NAD(P) binding site [chemical binding]; other site 444178008577 catalytic residues [active] 444178008578 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 444178008579 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 444178008580 substrate binding site [chemical binding]; other site 444178008581 oxyanion hole (OAH) forming residues; other site 444178008582 trimer interface [polypeptide binding]; other site 444178008583 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 444178008584 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 444178008585 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 444178008586 Transcriptional regulators [Transcription]; Region: PurR; COG1609 444178008587 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 444178008588 DNA binding site [nucleotide binding] 444178008589 domain linker motif; other site 444178008590 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 444178008591 putative dimerization interface [polypeptide binding]; other site 444178008592 putative ligand binding site [chemical binding]; other site 444178008593 Protein of unknown function (DUF993); Region: DUF993; pfam06187 444178008594 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 444178008595 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 444178008596 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 444178008597 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 444178008598 zinc binding site [ion binding]; other site 444178008599 putative ligand binding site [chemical binding]; other site 444178008600 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 444178008601 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 444178008602 TM-ABC transporter signature motif; other site 444178008603 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 444178008604 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 444178008605 Walker A/P-loop; other site 444178008606 ATP binding site [chemical binding]; other site 444178008607 Q-loop/lid; other site 444178008608 ABC transporter signature motif; other site 444178008609 Walker B; other site 444178008610 D-loop; other site 444178008611 H-loop/switch region; other site 444178008612 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 444178008613 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 444178008614 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 444178008615 ParB-like nuclease domain; Region: ParB; smart00470 444178008616 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 444178008617 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 444178008618 P-loop; other site 444178008619 Magnesium ion binding site [ion binding]; other site 444178008620 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 444178008621 Magnesium ion binding site [ion binding]; other site 444178008622 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 444178008623 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 444178008624 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 444178008625 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 444178008626 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 444178008627 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 444178008628 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 444178008629 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 444178008630 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 444178008631 trmE is a tRNA modification GTPase; Region: trmE; cd04164 444178008632 G1 box; other site 444178008633 G1 box; other site 444178008634 GTP/Mg2+ binding site [chemical binding]; other site 444178008635 GTP/Mg2+ binding site [chemical binding]; other site 444178008636 Switch I region; other site 444178008637 Switch I region; other site 444178008638 G2 box; other site 444178008639 G2 box; other site 444178008640 Switch II region; other site 444178008641 G3 box; other site 444178008642 G4 box; other site 444178008643 G5 box; other site 444178008644 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 444178008645 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 444178008646 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 444178008647 catalytic residues [active] 444178008648 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 444178008649 transcription termination factor Rho; Provisional; Region: rho; PRK09376 444178008650 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 444178008651 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 444178008652 RNA binding site [nucleotide binding]; other site 444178008653 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 444178008654 multimer interface [polypeptide binding]; other site 444178008655 Walker A motif; other site 444178008656 ATP binding site [chemical binding]; other site 444178008657 Walker B motif; other site 444178008658 Predicted membrane protein [Function unknown]; Region: COG1981 444178008659 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 444178008660 substrate binding site [chemical binding]; other site 444178008661 active site 444178008662 PEP synthetase regulatory protein; Provisional; Region: PRK05339 444178008663 Maf-like protein; Reviewed; Region: PRK00078 444178008664 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 444178008665 active site 444178008666 dimer interface [polypeptide binding]; other site 444178008667 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 444178008668 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 444178008669 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 444178008670 shikimate binding site; other site 444178008671 NAD(P) binding site [chemical binding]; other site 444178008672 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 444178008673 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 444178008674 CoA-binding site [chemical binding]; other site 444178008675 ATP-binding [chemical binding]; other site 444178008676 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 444178008677 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 444178008678 active site 444178008679 catalytic site [active] 444178008680 substrate binding site [chemical binding]; other site 444178008681 preprotein translocase subunit SecB; Validated; Region: PRK05751 444178008682 SecA binding site; other site 444178008683 Preprotein binding site; other site 444178008684 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 444178008685 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 444178008686 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 444178008687 MltA specific insert domain; Region: MltA; pfam03562 444178008688 3D domain; Region: 3D; pfam06725 444178008689 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 444178008690 Smr domain; Region: Smr; pfam01713 444178008691 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 444178008692 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 444178008693 sequence-specific DNA binding site [nucleotide binding]; other site 444178008694 salt bridge; other site 444178008695 Protein of unknown function (DUF1402); Region: DUF1402; pfam07182 444178008696 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 444178008697 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 444178008698 Walker A motif; other site 444178008699 ATP binding site [chemical binding]; other site 444178008700 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 444178008701 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 444178008702 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 444178008703 active site 444178008704 HslU subunit interaction site [polypeptide binding]; other site 444178008705 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 444178008706 putative active site pocket [active] 444178008707 4-fold oligomerization interface [polypeptide binding]; other site 444178008708 metal binding residues [ion binding]; metal-binding site 444178008709 3-fold/trimer interface [polypeptide binding]; other site 444178008710 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 444178008711 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 444178008712 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 444178008713 putative active site [active] 444178008714 oxyanion strand; other site 444178008715 catalytic triad [active] 444178008716 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 444178008717 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 444178008718 catalytic residues [active] 444178008719 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 444178008720 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 444178008721 substrate binding site [chemical binding]; other site 444178008722 glutamase interaction surface [polypeptide binding]; other site 444178008723 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 444178008724 metal binding site [ion binding]; metal-binding site 444178008725 pantothenate kinase; Provisional; Region: PRK05439 444178008726 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 444178008727 ATP-binding site [chemical binding]; other site 444178008728 CoA-binding site [chemical binding]; other site 444178008729 Mg2+-binding site [ion binding]; other site 444178008730 hypothetical protein; Provisional; Region: PRK09256 444178008731 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 444178008732 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 444178008733 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 444178008734 active site 444178008735 phosphorylation site [posttranslational modification] 444178008736 intermolecular recognition site; other site 444178008737 dimerization interface [polypeptide binding]; other site 444178008738 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 444178008739 DNA binding site [nucleotide binding] 444178008740 Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755 444178008741 Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756 444178008742 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 444178008743 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 444178008744 dimerization interface [polypeptide binding]; other site 444178008745 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 444178008746 dimer interface [polypeptide binding]; other site 444178008747 phosphorylation site [posttranslational modification] 444178008748 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 444178008749 ATP binding site [chemical binding]; other site 444178008750 Mg2+ binding site [ion binding]; other site 444178008751 G-X-G motif; other site 444178008752 Serine kinase of the HPr protein, regulates carbohydrate metabolism [Signal transduction mechanisms]; Region: HprK; COG1493 444178008753 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 444178008754 Hpr binding site; other site 444178008755 active site 444178008756 homohexamer subunit interaction site [polypeptide binding]; other site 444178008757 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 444178008758 active pocket/dimerization site; other site 444178008759 active site 444178008760 phosphorylation site [posttranslational modification] 444178008761 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 444178008762 dimerization domain swap beta strand [polypeptide binding]; other site 444178008763 regulatory protein interface [polypeptide binding]; other site 444178008764 active site 444178008765 regulatory phosphorylation site [posttranslational modification]; other site 444178008766 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 444178008767 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 444178008768 homotetramer interface [polypeptide binding]; other site 444178008769 ligand binding site [chemical binding]; other site 444178008770 catalytic site [active] 444178008771 NAD binding site [chemical binding]; other site 444178008772 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 444178008773 PAS fold; Region: PAS_7; pfam12860 444178008774 PAS fold; Region: PAS_7; pfam12860 444178008775 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 444178008776 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 444178008777 dimer interface [polypeptide binding]; other site 444178008778 phosphorylation site [posttranslational modification] 444178008779 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 444178008780 ATP binding site [chemical binding]; other site 444178008781 Mg2+ binding site [ion binding]; other site 444178008782 G-X-G motif; other site 444178008783 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 444178008784 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 444178008785 Phosphotransferase enzyme family; Region: APH; pfam01636 444178008786 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 444178008787 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 444178008788 Substrate binding site; other site 444178008789 metal-binding site 444178008790 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 444178008791 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 444178008792 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 444178008793 Part of AAA domain; Region: AAA_19; pfam13245 444178008794 Family description; Region: UvrD_C_2; pfam13538 444178008795 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 444178008796 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 444178008797 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 444178008798 catalytic residues [active] 444178008799 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 444178008800 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 444178008801 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 444178008802 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 444178008803 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 444178008804 substrate binding site [chemical binding]; other site 444178008805 active site 444178008806 catalytic residues [active] 444178008807 heterodimer interface [polypeptide binding]; other site 444178008808 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 444178008809 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 444178008810 pyridoxal 5'-phosphate binding site [chemical binding]; other site 444178008811 catalytic residue [active] 444178008812 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 444178008813 active site 444178008814 Uncharacterized conserved protein [Function unknown]; Region: COG1434 444178008815 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 444178008816 putative active site [active] 444178008817 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 444178008818 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 444178008819 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 444178008820 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 444178008821 benzoate transporter; Region: benE; TIGR00843 444178008822 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 444178008823 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 444178008824 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 444178008825 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 444178008826 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 444178008827 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 444178008828 23S rRNA binding site [nucleotide binding]; other site 444178008829 L21 binding site [polypeptide binding]; other site 444178008830 L13 binding site [polypeptide binding]; other site 444178008831 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 444178008832 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 444178008833 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 444178008834 dimer interface [polypeptide binding]; other site 444178008835 motif 1; other site 444178008836 active site 444178008837 motif 2; other site 444178008838 motif 3; other site 444178008839 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 444178008840 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 444178008841 putative tRNA-binding site [nucleotide binding]; other site 444178008842 B3/4 domain; Region: B3_4; pfam03483 444178008843 tRNA synthetase B5 domain; Region: B5; smart00874 444178008844 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 444178008845 dimer interface [polypeptide binding]; other site 444178008846 motif 1; other site 444178008847 motif 3; other site 444178008848 motif 2; other site 444178008849 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 444178008850 NAD-specific glutamate dehydrogenase; Region: NAD-GH; pfam10712 444178008851 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 444178008852 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 444178008853 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 444178008854 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 444178008855 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 444178008856 nucleotide binding site [chemical binding]; other site 444178008857 NEF interaction site [polypeptide binding]; other site 444178008858 SBD interface [polypeptide binding]; other site 444178008859 chaperone protein DnaJ; Provisional; Region: PRK10767 444178008860 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 444178008861 HSP70 interaction site [polypeptide binding]; other site 444178008862 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 444178008863 substrate binding site [polypeptide binding]; other site 444178008864 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 444178008865 Zn binding sites [ion binding]; other site 444178008866 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 444178008867 dimer interface [polypeptide binding]; other site 444178008868 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 444178008869 S-adenosylmethionine binding site [chemical binding]; other site 444178008870 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 444178008871 active site 444178008872 dimer interface [polypeptide binding]; other site 444178008873 Uncharacterized conserved protein [Function unknown]; Region: COG5470 444178008874 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 444178008875 glutathione synthetase; Provisional; Region: PRK05246 444178008876 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 444178008877 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 444178008878 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 444178008879 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 444178008880 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 444178008881 Walker A motif; other site 444178008882 ATP binding site [chemical binding]; other site 444178008883 Walker B motif; other site 444178008884 arginine finger; other site 444178008885 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 444178008886 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 444178008887 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 444178008888 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 444178008889 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 444178008890 PBP superfamily domain; Region: PBP_like_2; pfam12849 444178008891 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 444178008892 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 444178008893 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178008894 dimer interface [polypeptide binding]; other site 444178008895 conserved gate region; other site 444178008896 putative PBP binding loops; other site 444178008897 ABC-ATPase subunit interface; other site 444178008898 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 444178008899 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 444178008900 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 444178008901 dimer interface [polypeptide binding]; other site 444178008902 conserved gate region; other site 444178008903 putative PBP binding loops; other site 444178008904 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 444178008905 ABC-ATPase subunit interface; other site 444178008906 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 444178008907 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 444178008908 Walker A/P-loop; other site 444178008909 ATP binding site [chemical binding]; other site 444178008910 Q-loop/lid; other site 444178008911 ABC transporter signature motif; other site 444178008912 Walker B; other site 444178008913 D-loop; other site 444178008914 H-loop/switch region; other site 444178008915 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 444178008916 PhoU domain; Region: PhoU; pfam01895 444178008917 PhoU domain; Region: PhoU; pfam01895 444178008918 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 444178008919 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 444178008920 active site 444178008921 phosphorylation site [posttranslational modification] 444178008922 intermolecular recognition site; other site 444178008923 dimerization interface [polypeptide binding]; other site 444178008924 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 444178008925 DNA binding site [nucleotide binding] 444178008926 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 444178008927 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 444178008928 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 444178008929 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 444178008930 dimerization interface [polypeptide binding]; other site 444178008931 DPS ferroxidase diiron center [ion binding]; other site 444178008932 ion pore; other site 444178008933 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 444178008934 Glycoprotease family; Region: Peptidase_M22; pfam00814 444178008935 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 444178008936 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 444178008937 Coenzyme A binding pocket [chemical binding]; other site 444178008938 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 444178008939 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 444178008940 putative acyl-acceptor binding pocket; other site 444178008941 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 444178008942 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 444178008943 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 444178008944 FeS/SAM binding site; other site 444178008945 TRAM domain; Region: TRAM; cl01282 444178008946 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 444178008947 PhoH-like protein; Region: PhoH; pfam02562 444178008948 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 444178008949 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 444178008950 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 444178008951 Transporter associated domain; Region: CorC_HlyC; smart01091 444178008952 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 444178008953 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 444178008954 putative active site [active] 444178008955 catalytic triad [active] 444178008956 putative dimer interface [polypeptide binding]; other site 444178008957 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 444178008958 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 444178008959 non-specific DNA binding site [nucleotide binding]; other site 444178008960 salt bridge; other site 444178008961 sequence-specific DNA binding site [nucleotide binding]; other site 444178008962 S-adenosylmethionine synthetase; Validated; Region: PRK05250 444178008963 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 444178008964 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 444178008965 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 444178008966 Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only]; Region: COG0220 444178008967 ribosome maturation protein RimP; Reviewed; Region: PRK00092 444178008968 Sm and related proteins; Region: Sm_like; cl00259 444178008969 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 444178008970 putative oligomer interface [polypeptide binding]; other site 444178008971 putative RNA binding site [nucleotide binding]; other site 444178008972 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 444178008973 NusA N-terminal domain; Region: NusA_N; pfam08529 444178008974 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 444178008975 RNA binding site [nucleotide binding]; other site 444178008976 homodimer interface [polypeptide binding]; other site 444178008977 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 444178008978 G-X-X-G motif; other site 444178008979 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 444178008980 G-X-X-G motif; other site 444178008981 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 444178008982 hypothetical protein; Provisional; Region: PRK09190 444178008983 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 444178008984 putative RNA binding cleft [nucleotide binding]; other site 444178008985 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 444178008986 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 444178008987 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 444178008988 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 444178008989 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 444178008990 G1 box; other site 444178008991 putative GEF interaction site [polypeptide binding]; other site 444178008992 GTP/Mg2+ binding site [chemical binding]; other site 444178008993 Switch I region; other site 444178008994 G2 box; other site 444178008995 G3 box; other site 444178008996 Switch II region; other site 444178008997 G4 box; other site 444178008998 G5 box; other site 444178008999 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 444178009000 Translation-initiation factor 2; Region: IF-2; pfam11987 444178009001 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 444178009002 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 444178009003 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 444178009004 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 444178009005 RNA binding site [nucleotide binding]; other site 444178009006 active site 444178009007 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 444178009008 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 444178009009 16S/18S rRNA binding site [nucleotide binding]; other site 444178009010 S13e-L30e interaction site [polypeptide binding]; other site 444178009011 25S rRNA binding site [nucleotide binding]; other site 444178009012 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 444178009013 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 444178009014 RNase E interface [polypeptide binding]; other site 444178009015 trimer interface [polypeptide binding]; other site 444178009016 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 444178009017 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 444178009018 RNase E interface [polypeptide binding]; other site 444178009019 trimer interface [polypeptide binding]; other site 444178009020 active site 444178009021 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 444178009022 putative nucleic acid binding region [nucleotide binding]; other site 444178009023 G-X-X-G motif; other site 444178009024 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 444178009025 RNA binding site [nucleotide binding]; other site 444178009026 domain interface; other site 444178009027 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505 444178009028 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 444178009029 NAD binding site [chemical binding]; other site 444178009030 homotetramer interface [polypeptide binding]; other site 444178009031 homodimer interface [polypeptide binding]; other site 444178009032 substrate binding site [chemical binding]; other site 444178009033 active site 444178009034 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 444178009035 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 444178009036 dimer interface [polypeptide binding]; other site 444178009037 active site 444178009038 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 444178009039 active site 1 [active] 444178009040 dimer interface [polypeptide binding]; other site 444178009041 active site 2 [active] 444178009042 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 444178009043 metal binding site 2 [ion binding]; metal-binding site 444178009044 putative DNA binding helix; other site 444178009045 metal binding site 1 [ion binding]; metal-binding site 444178009046 dimer interface [polypeptide binding]; other site 444178009047 structural Zn2+ binding site [ion binding]; other site 444178009048 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 444178009049 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 444178009050 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 444178009051 Bacterial SH3 domain; Region: SH3_4; pfam06347 444178009052 Bacterial SH3 domain; Region: SH3_4; pfam06347 444178009053 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 444178009054 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 444178009055 dimerization interface [polypeptide binding]; other site 444178009056 ligand binding site [chemical binding]; other site 444178009057 NADP binding site [chemical binding]; other site 444178009058 catalytic site [active] 444178009059 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 444178009060 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 444178009061 NlpC/P60 family; Region: NLPC_P60; cl17555 444178009062 Transcriptional regulators [Transcription]; Region: MarR; COG1846 444178009063 MarR family; Region: MarR; pfam01047 444178009064 multifunctional aminopeptidase A; Provisional; Region: PRK00913 444178009065 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 444178009066 interface (dimer of trimers) [polypeptide binding]; other site 444178009067 Substrate-binding/catalytic site; other site 444178009068 Zn-binding sites [ion binding]; other site 444178009069 Flp/Fap pilin component; Region: Flp_Fap; cl01585 444178009070 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 444178009071 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 444178009072 DNA binding site [nucleotide binding] 444178009073 catalytic residue [active] 444178009074 H2TH interface [polypeptide binding]; other site 444178009075 putative catalytic residues [active] 444178009076 turnover-facilitating residue; other site 444178009077 intercalation triad [nucleotide binding]; other site 444178009078 8OG recognition residue [nucleotide binding]; other site 444178009079 putative reading head residues; other site 444178009080 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 444178009081 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 444178009082 enoyl-CoA hydratase; Provisional; Region: PRK05862 444178009083 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 444178009084 substrate binding site [chemical binding]; other site 444178009085 oxyanion hole (OAH) forming residues; other site 444178009086 trimer interface [polypeptide binding]; other site 444178009087 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239