-- dump date 20140619_011615 -- class Genbank::misc_feature -- table misc_feature_note -- id note 470137000001 S-element; BSUIS_B0002 470137000002 replication initiation protein RepC; Provisional; Region: PRK13824 470137000003 Replication protein C N-terminal domain; Region: RP-C; pfam03428 470137000004 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 470137000005 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 470137000006 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 470137000007 substrate binding site [chemical binding]; other site 470137000008 dimer interface [polypeptide binding]; other site 470137000009 ATP binding site [chemical binding]; other site 470137000010 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 470137000011 active site 470137000012 tetramer interface [polypeptide binding]; other site 470137000013 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 470137000014 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 470137000015 TM-ABC transporter signature motif; other site 470137000016 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 470137000017 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 470137000018 TM-ABC transporter signature motif; other site 470137000019 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 470137000020 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 470137000021 Walker A/P-loop; other site 470137000022 ATP binding site [chemical binding]; other site 470137000023 Q-loop/lid; other site 470137000024 ABC transporter signature motif; other site 470137000025 Walker B; other site 470137000026 D-loop; other site 470137000027 H-loop/switch region; other site 470137000028 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 470137000029 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 470137000030 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 470137000031 ligand binding site [chemical binding]; other site 470137000032 Predicted secreted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5664 470137000033 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 470137000034 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 470137000035 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 470137000036 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 470137000037 putative NAD(P) binding site [chemical binding]; other site 470137000038 active site 470137000039 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 470137000040 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 470137000041 acyl-activating enzyme (AAE) consensus motif; other site 470137000042 active site 470137000043 AMP binding site [chemical binding]; other site 470137000044 substrate binding site [chemical binding]; other site 470137000045 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 470137000046 isochorismate synthases; Region: isochor_syn; TIGR00543 470137000047 Condensation domain; Region: Condensation; pfam00668 470137000048 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 470137000049 bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108 470137000050 Moco binding site; other site 470137000051 metal coordination site [ion binding]; other site 470137000052 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 470137000053 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 470137000054 pentapeptide MXKDX repeat protein; Region: penta_MxKDx; TIGR02953 470137000055 RNA polymerase sigma factor; Provisional; Region: PRK12539 470137000056 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 470137000057 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 470137000058 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4944 470137000059 Transcriptional regulators [Transcription]; Region: FadR; COG2186 470137000060 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 470137000061 DNA-binding site [nucleotide binding]; DNA binding site 470137000062 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 470137000063 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 470137000064 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 470137000065 putative ligand binding site [chemical binding]; other site 470137000066 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 470137000067 TM-ABC transporter signature motif; other site 470137000068 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 470137000069 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 470137000070 TM-ABC transporter signature motif; other site 470137000071 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 470137000072 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 470137000073 Walker A/P-loop; other site 470137000074 ATP binding site [chemical binding]; other site 470137000075 Q-loop/lid; other site 470137000076 ABC transporter signature motif; other site 470137000077 Walker B; other site 470137000078 D-loop; other site 470137000079 H-loop/switch region; other site 470137000080 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 470137000081 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 470137000082 Walker A/P-loop; other site 470137000083 ATP binding site [chemical binding]; other site 470137000084 Q-loop/lid; other site 470137000085 ABC transporter signature motif; other site 470137000086 Walker B; other site 470137000087 D-loop; other site 470137000088 H-loop/switch region; other site 470137000089 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 470137000090 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 470137000091 active site 470137000092 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 470137000093 classical (c) SDRs; Region: SDR_c; cd05233 470137000094 NAD(P) binding site [chemical binding]; other site 470137000095 active site 470137000096 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 470137000097 classical (c) SDRs; Region: SDR_c; cd05233 470137000098 NAD(P) binding site [chemical binding]; other site 470137000099 active site 470137000100 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 470137000101 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 470137000102 tetramer interface [polypeptide binding]; other site 470137000103 TPP-binding site [chemical binding]; other site 470137000104 heterodimer interface [polypeptide binding]; other site 470137000105 phosphorylation loop region [posttranslational modification] 470137000106 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 470137000107 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 470137000108 alpha subunit interface [polypeptide binding]; other site 470137000109 TPP binding site [chemical binding]; other site 470137000110 heterodimer interface [polypeptide binding]; other site 470137000111 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 470137000112 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 470137000113 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 470137000114 E3 interaction surface; other site 470137000115 lipoyl attachment site [posttranslational modification]; other site 470137000116 e3 binding domain; Region: E3_binding; pfam02817 470137000117 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 470137000118 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 470137000119 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 470137000120 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 470137000121 shikimate binding site; other site 470137000122 NAD(P) binding site [chemical binding]; other site 470137000123 magnesium-transporting ATPase; Provisional; Region: PRK15122 470137000124 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 470137000125 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 470137000126 Soluble P-type ATPase [General function prediction only]; Region: COG4087 470137000127 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 470137000128 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 470137000129 MgtC family; Region: MgtC; pfam02308 470137000130 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 470137000131 ATP binding site [chemical binding]; other site 470137000132 Mg2+ binding site [ion binding]; other site 470137000133 G-X-G motif; other site 470137000134 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 470137000135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 470137000136 active site 470137000137 phosphorylation site [posttranslational modification] 470137000138 intermolecular recognition site; other site 470137000139 dimerization interface [polypeptide binding]; other site 470137000140 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 470137000141 dimerization interface [polypeptide binding]; other site 470137000142 DNA binding residues [nucleotide binding] 470137000143 Response regulator receiver domain; Region: Response_reg; pfam00072 470137000144 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 470137000145 active site 470137000146 phosphorylation site [posttranslational modification] 470137000147 intermolecular recognition site; other site 470137000148 dimerization interface [polypeptide binding]; other site 470137000149 N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: HutG; COG3741 470137000150 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 470137000151 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 470137000152 active site 470137000153 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 470137000154 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 470137000155 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 470137000156 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 470137000157 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 470137000158 putative dimer interface [polypeptide binding]; other site 470137000159 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 470137000160 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 470137000161 active site 470137000162 dimer interface [polypeptide binding]; other site 470137000163 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 470137000164 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 470137000165 active site 470137000166 FMN binding site [chemical binding]; other site 470137000167 substrate binding site [chemical binding]; other site 470137000168 3Fe-4S cluster binding site [ion binding]; other site 470137000169 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 470137000170 domain interface; other site 470137000171 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 470137000172 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 470137000173 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 470137000174 active site 470137000175 catalytic triad [active] 470137000176 oxyanion hole [active] 470137000177 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 470137000178 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 470137000179 ligand binding site [chemical binding]; other site 470137000180 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 470137000181 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 470137000182 ATP binding site [chemical binding]; other site 470137000183 Walker A motif; other site 470137000184 hexamer interface [polypeptide binding]; other site 470137000185 Walker B motif; other site 470137000186 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 470137000187 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 470137000188 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 470137000189 VirB7 interaction site; other site 470137000190 Type IV secretory pathway, component VirB8 [Intracellular trafficking and secretion]; Region: VirB8; COG3736 470137000191 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 470137000192 Type IV secretory pathway, VirB6 components [Intracellular trafficking and secretion]; Region: VirB6; COG3704 470137000193 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 470137000194 Type IV secretion system proteins; Region: T4SS; pfam07996 470137000195 Type IV secretory pathway, VirB4 components [Intracellular trafficking and secretion]; Region: VirB4; COG3451 470137000196 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 470137000197 Type IV secretory pathway, VirB3 components [Intracellular trafficking and secretion]; Region: VirB3; COG3702 470137000198 TrbC/VIRB2 family; Region: TrbC; pfam04956 470137000199 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 470137000200 N-acetyl-D-glucosamine binding site [chemical binding]; other site 470137000201 catalytic residue [active] 470137000202 lytic murein transglycosylase; Region: MltB_2; TIGR02283 470137000203 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 470137000204 N-acetyl-D-glucosamine binding site [chemical binding]; other site 470137000205 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 470137000206 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 470137000207 active site 470137000208 tetramer interface; other site 470137000209 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5338 470137000210 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 470137000211 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 470137000212 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 470137000213 putative active site [active] 470137000214 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 470137000215 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 470137000216 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 470137000217 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 470137000218 ferrochelatase; Reviewed; Region: hemH; PRK00035 470137000219 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 470137000220 C-terminal domain interface [polypeptide binding]; other site 470137000221 active site 470137000222 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 470137000223 active site 470137000224 N-terminal domain interface [polypeptide binding]; other site 470137000225 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 470137000226 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 470137000227 hypothetical protein; Provisional; Region: PRK07546 470137000228 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 470137000229 substrate-cofactor binding pocket; other site 470137000230 pyridoxal 5'-phosphate binding site [chemical binding]; other site 470137000231 homodimer interface [polypeptide binding]; other site 470137000232 catalytic residue [active] 470137000233 aminodeoxychorismate synthase; Provisional; Region: PRK07508 470137000234 chorismate binding enzyme; Region: Chorismate_bind; cl10555 470137000235 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 470137000236 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 470137000237 active site 470137000238 Zn binding site [ion binding]; other site 470137000239 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 470137000240 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 470137000241 active site 470137000242 phosphorylation site [posttranslational modification] 470137000243 intermolecular recognition site; other site 470137000244 dimerization interface [polypeptide binding]; other site 470137000245 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 470137000246 Walker A motif; other site 470137000247 ATP binding site [chemical binding]; other site 470137000248 Walker B motif; other site 470137000249 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 470137000250 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 470137000251 Bacterial protein of unknown function (DUF882); Region: Peptidase_M15_2; pfam05951 470137000252 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 470137000253 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 470137000254 active site 470137000255 intersubunit interface [polypeptide binding]; other site 470137000256 catalytic residue [active] 470137000257 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 470137000258 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 470137000259 active site residue [active] 470137000260 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 470137000261 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 470137000262 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137000263 dimer interface [polypeptide binding]; other site 470137000264 conserved gate region; other site 470137000265 putative PBP binding loops; other site 470137000266 ABC-ATPase subunit interface; other site 470137000267 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 470137000268 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 470137000269 Walker A/P-loop; other site 470137000270 ATP binding site [chemical binding]; other site 470137000271 Q-loop/lid; other site 470137000272 ABC transporter signature motif; other site 470137000273 Walker B; other site 470137000274 D-loop; other site 470137000275 H-loop/switch region; other site 470137000276 TOBE domain; Region: TOBE; cl01440 470137000277 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 470137000278 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 470137000279 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 470137000280 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 470137000281 LysR family transcriptional regulator; Provisional; Region: PRK14997 470137000282 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 470137000283 putative effector binding pocket; other site 470137000284 dimerization interface [polypeptide binding]; other site 470137000285 amidase; Provisional; Region: PRK08310 470137000286 indole-3-acetamide amidohydrolase; Region: PLN02722 470137000287 speF leader; BSUIS_B0105 470137000288 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 470137000289 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 470137000290 dimer interface [polypeptide binding]; other site 470137000291 active site 470137000292 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 470137000293 catalytic residues [active] 470137000294 substrate binding site [chemical binding]; other site 470137000295 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 470137000296 Chain length determinant protein; Region: Wzz; pfam02706 470137000297 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 470137000298 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 470137000299 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 470137000300 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 470137000301 active site 470137000302 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 470137000303 O-Antigen ligase; Region: Wzy_C; pfam04932 470137000304 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 470137000305 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 470137000306 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 470137000307 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 470137000308 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 470137000309 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG0362 470137000310 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 470137000311 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 470137000312 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 470137000313 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 470137000314 Walker A/P-loop; other site 470137000315 ATP binding site [chemical binding]; other site 470137000316 Q-loop/lid; other site 470137000317 ABC transporter signature motif; other site 470137000318 Walker B; other site 470137000319 D-loop; other site 470137000320 H-loop/switch region; other site 470137000321 TOBE domain; Region: TOBE_2; pfam08402 470137000322 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 470137000323 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137000324 dimer interface [polypeptide binding]; other site 470137000325 conserved gate region; other site 470137000326 putative PBP binding loops; other site 470137000327 ABC-ATPase subunit interface; other site 470137000328 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137000329 dimer interface [polypeptide binding]; other site 470137000330 conserved gate region; other site 470137000331 putative PBP binding loops; other site 470137000332 ABC-ATPase subunit interface; other site 470137000333 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 470137000334 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 470137000335 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 470137000336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 470137000337 putative substrate translocation pore; other site 470137000338 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 470137000339 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 470137000340 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 470137000341 Autoinducer binding domain; Region: Autoind_bind; pfam03472 470137000342 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 470137000343 DNA binding residues [nucleotide binding] 470137000344 dimerization interface [polypeptide binding]; other site 470137000345 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377 470137000346 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 470137000347 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 470137000348 Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868 470137000349 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 470137000350 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 470137000351 flagellar motor protein MotA; Validated; Region: PRK09110 470137000352 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 470137000353 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 470137000354 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642 470137000355 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 470137000356 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 470137000357 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002 470137000358 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 470137000359 Walker A motif; other site 470137000360 ATP binding site [chemical binding]; other site 470137000361 Walker B motif; other site 470137000362 PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389 470137000363 active site 470137000364 GtrA-like protein; Region: GtrA; pfam04138 470137000365 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 470137000366 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 470137000367 Ligand binding site; other site 470137000368 Putative Catalytic site; other site 470137000369 DXD motif; other site 470137000370 Peptidase family M48; Region: Peptidase_M48; cl12018 470137000371 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 470137000372 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 470137000373 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 470137000374 Helix-turn-helix domain; Region: HTH_18; pfam12833 470137000375 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 470137000376 Transposase; Region: HTH_Tnp_1; cl17663 470137000377 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 470137000378 D-galactonate transporter; Region: 2A0114; TIGR00893 470137000379 putative substrate translocation pore; other site 470137000380 putative aldolase; Validated; Region: PRK08130 470137000381 intersubunit interface [polypeptide binding]; other site 470137000382 active site 470137000383 Zn2+ binding site [ion binding]; other site 470137000384 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 470137000385 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 470137000386 putative NAD(P) binding site [chemical binding]; other site 470137000387 active site 470137000388 putative substrate binding site [chemical binding]; other site 470137000389 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 470137000390 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 470137000391 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 470137000392 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 470137000393 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 470137000394 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003 470137000395 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782 470137000396 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 470137000397 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 470137000398 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790 470137000399 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 470137000400 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 470137000401 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK06005 470137000402 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 470137000403 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 470137000404 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 470137000405 Uncharacterized conserved protein [Function unknown]; Region: COG3334 470137000406 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 470137000407 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 470137000408 FliP family; Region: FliP; cl00593 470137000409 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 470137000410 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4893 470137000411 Transcriptional regulator [Transcription]; Region: LysR; COG0583 470137000412 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 470137000413 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 470137000414 putative dimerization interface [polypeptide binding]; other site 470137000415 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 470137000416 CoA-transferase family III; Region: CoA_transf_3; pfam02515 470137000417 Uncharacterized conserved protein [Function unknown]; Region: COG3777 470137000418 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 470137000419 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 470137000420 active site 2 [active] 470137000421 active site 1 [active] 470137000422 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 470137000423 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 470137000424 Cytochrome c2 [Energy production and conversion]; Region: COG3474 470137000425 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841 470137000426 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 470137000427 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 470137000428 DNA-binding site [nucleotide binding]; DNA binding site 470137000429 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 470137000430 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 470137000431 transcriptional activator TtdR; Provisional; Region: PRK09801 470137000432 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 470137000433 putative effector binding pocket; other site 470137000434 dimerization interface [polypeptide binding]; other site 470137000435 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 470137000436 FAD binding domain; Region: FAD_binding_4; pfam01565 470137000437 FAD binding domain; Region: FAD_binding_4; pfam01565 470137000438 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 470137000439 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 470137000440 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 470137000441 Cysteine-rich domain; Region: CCG; pfam02754 470137000442 Cysteine-rich domain; Region: CCG; pfam02754 470137000443 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 470137000444 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 470137000445 active site 470137000446 catalytic tetrad [active] 470137000447 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 470137000448 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 470137000449 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 470137000450 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 470137000451 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 470137000452 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 470137000453 dimer interface [polypeptide binding]; other site 470137000454 motif 1; other site 470137000455 motif 2; other site 470137000456 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 470137000457 active site 470137000458 motif 3; other site 470137000459 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 470137000460 anticodon binding site; other site 470137000461 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295 470137000462 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 470137000463 motif 1; other site 470137000464 dimer interface [polypeptide binding]; other site 470137000465 active site 470137000466 motif 2; other site 470137000467 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 470137000468 active site 470137000469 motif 3; other site 470137000470 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583 470137000471 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 470137000472 Predicted membrane protein [Function unknown]; Region: COG2259 470137000473 fumarate hydratase; Reviewed; Region: fumC; PRK00485 470137000474 Class II fumarases; Region: Fumarase_classII; cd01362 470137000475 active site 470137000476 tetramer interface [polypeptide binding]; other site 470137000477 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 470137000478 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 470137000479 ring oligomerisation interface [polypeptide binding]; other site 470137000480 ATP/Mg binding site [chemical binding]; other site 470137000481 stacking interactions; other site 470137000482 hinge regions; other site 470137000483 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 470137000484 oligomerisation interface [polypeptide binding]; other site 470137000485 mobile loop; other site 470137000486 roof hairpin; other site 470137000487 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 470137000488 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 470137000489 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 470137000490 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 470137000491 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 470137000492 active site 470137000493 Riboflavin kinase; Region: Flavokinase; smart00904 470137000494 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 470137000495 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 470137000496 active site 470137000497 HIGH motif; other site 470137000498 nucleotide binding site [chemical binding]; other site 470137000499 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 470137000500 active site 470137000501 KMSKS motif; other site 470137000502 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 470137000503 tRNA binding surface [nucleotide binding]; other site 470137000504 anticodon binding site; other site 470137000505 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 470137000506 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 470137000507 nucleoside/Zn binding site; other site 470137000508 dimer interface [polypeptide binding]; other site 470137000509 catalytic motif [active] 470137000510 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 470137000511 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 470137000512 RNA binding surface [nucleotide binding]; other site 470137000513 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 470137000514 active site 470137000515 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 470137000516 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 470137000517 S-adenosylmethionine binding site [chemical binding]; other site 470137000518 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 470137000519 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 470137000520 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 470137000521 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 470137000522 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 470137000523 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 470137000524 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 470137000525 TrkA-N domain; Region: TrkA_N; pfam02254 470137000526 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 470137000527 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 470137000528 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 470137000529 active site 470137000530 Domain of unknown function (DUF4170); Region: DUF4170; pfam13773 470137000531 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 470137000532 putative acyl-acceptor binding pocket; other site 470137000533 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 470137000534 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 470137000535 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 470137000536 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 470137000537 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 470137000538 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3908 470137000539 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 470137000540 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 470137000541 ATP binding site [chemical binding]; other site 470137000542 Mg2+ binding site [ion binding]; other site 470137000543 G-X-G motif; other site 470137000544 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 470137000545 ATP binding site [chemical binding]; other site 470137000546 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 470137000547 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 470137000548 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 470137000549 active site 470137000550 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 470137000551 Transcriptional regulator [Transcription]; Region: IclR; COG1414 470137000552 Bacterial transcriptional regulator; Region: IclR; pfam01614 470137000553 enoyl-CoA hydratase; Provisional; Region: PRK08138 470137000554 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 470137000555 substrate binding site [chemical binding]; other site 470137000556 oxyanion hole (OAH) forming residues; other site 470137000557 trimer interface [polypeptide binding]; other site 470137000558 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 470137000559 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 470137000560 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 470137000561 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 470137000562 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 470137000563 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 470137000564 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 470137000565 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 470137000566 CoA-transferase family III; Region: CoA_transf_3; pfam02515 470137000567 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg7; cd04786 470137000568 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 470137000569 DNA binding residues [nucleotide binding] 470137000570 putative dimer interface [polypeptide binding]; other site 470137000571 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 470137000572 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 470137000573 potential catalytic triad [active] 470137000574 conserved cys residue [active] 470137000575 sensor protein QseC; Provisional; Region: PRK10337 470137000576 HAMP domain; Region: HAMP; pfam00672 470137000577 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 470137000578 dimer interface [polypeptide binding]; other site 470137000579 phosphorylation site [posttranslational modification] 470137000580 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 470137000581 Mg2+ binding site [ion binding]; other site 470137000582 G-X-G motif; other site 470137000583 Uncharacterized conserved protein [Function unknown]; Region: COG5591 470137000584 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 470137000585 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 470137000586 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 470137000587 Flavodoxin; Region: Flavodoxin_1; pfam00258 470137000588 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like2; cd06201 470137000589 FAD binding pocket [chemical binding]; other site 470137000590 FAD binding motif [chemical binding]; other site 470137000591 catalytic residues [active] 470137000592 NAD binding pocket [chemical binding]; other site 470137000593 phosphate binding motif [ion binding]; other site 470137000594 beta-alpha-beta structure motif; other site 470137000595 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 470137000596 ApbE family; Region: ApbE; pfam02424 470137000597 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 470137000598 GAF domain; Region: GAF; pfam01590 470137000599 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 470137000600 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 470137000601 metal binding site [ion binding]; metal-binding site 470137000602 active site 470137000603 I-site; other site 470137000604 Transcriptional regulators [Transcription]; Region: GntR; COG1802 470137000605 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 470137000606 DNA-binding site [nucleotide binding]; DNA binding site 470137000607 FCD domain; Region: FCD; pfam07729 470137000608 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 470137000609 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 470137000610 inhibitor site; inhibition site 470137000611 active site 470137000612 dimer interface [polypeptide binding]; other site 470137000613 catalytic residue [active] 470137000614 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 470137000615 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 470137000616 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 470137000617 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 470137000618 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 470137000619 Cytochrome c; Region: Cytochrom_C; pfam00034 470137000620 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 470137000621 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 470137000622 Binuclear center (active site) [active] 470137000623 K-pathway; other site 470137000624 Putative proton exit pathway; other site 470137000625 MoxR-like ATPases [General function prediction only]; Region: COG0714 470137000626 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 470137000627 Walker A motif; other site 470137000628 ATP binding site [chemical binding]; other site 470137000629 Walker B motif; other site 470137000630 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 470137000631 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 470137000632 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 470137000633 metal ion-dependent adhesion site (MIDAS); other site 470137000634 Uncharacterized conserved protein [Function unknown]; Region: COG4309 470137000635 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 470137000636 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 470137000637 CPxP motif; other site 470137000638 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 470137000639 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 470137000640 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 470137000641 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 470137000642 nucleophilic elbow; other site 470137000643 catalytic triad; other site 470137000644 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 470137000645 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 470137000646 Multicopper oxidase; Region: Cu-oxidase; pfam00394 470137000647 Uncharacterized conserved protein [Function unknown]; Region: COG1262 470137000648 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 470137000649 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 470137000650 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 470137000651 ligand binding site [chemical binding]; other site 470137000652 flexible hinge region; other site 470137000653 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 470137000654 putative switch regulator; other site 470137000655 non-specific DNA interactions [nucleotide binding]; other site 470137000656 DNA binding site [nucleotide binding] 470137000657 sequence specific DNA binding site [nucleotide binding]; other site 470137000658 putative cAMP binding site [chemical binding]; other site 470137000659 Transcriptional regulators [Transcription]; Region: PurR; COG1609 470137000660 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 470137000661 DNA binding site [nucleotide binding] 470137000662 domain linker motif; other site 470137000663 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 470137000664 dimerization interface [polypeptide binding]; other site 470137000665 ligand binding site [chemical binding]; other site 470137000666 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 470137000667 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 470137000668 putative ligand binding site [chemical binding]; other site 470137000669 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 470137000670 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 470137000671 Walker A/P-loop; other site 470137000672 ATP binding site [chemical binding]; other site 470137000673 Q-loop/lid; other site 470137000674 ABC transporter signature motif; other site 470137000675 Walker B; other site 470137000676 D-loop; other site 470137000677 H-loop/switch region; other site 470137000678 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 470137000679 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 470137000680 TM-ABC transporter signature motif; other site 470137000681 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 470137000682 classical (c) SDRs; Region: SDR_c; cd05233 470137000683 NAD(P) binding site [chemical binding]; other site 470137000684 active site 470137000685 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 470137000686 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 470137000687 N- and C-terminal domain interface [polypeptide binding]; other site 470137000688 active site 470137000689 MgATP binding site [chemical binding]; other site 470137000690 catalytic site [active] 470137000691 metal binding site [ion binding]; metal-binding site 470137000692 carbohydrate binding site [chemical binding]; other site 470137000693 putative homodimer interface [polypeptide binding]; other site 470137000694 RES domain; Region: RES; smart00953 470137000695 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 470137000696 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 470137000697 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 470137000698 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 470137000699 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 470137000700 ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163 470137000701 4Fe-4S binding domain; Region: Fer4_5; pfam12801 470137000702 4Fe-4S binding domain; Region: Fer4_5; pfam12801 470137000703 nitrous-oxide reductase; Validated; Region: PRK02888 470137000704 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 470137000705 Nitrous oxidase accessory protein [Inorganic ion transport and metabolism]; Region: NosD; COG3420 470137000706 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 470137000707 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 470137000708 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 470137000709 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 470137000710 Walker A/P-loop; other site 470137000711 ATP binding site [chemical binding]; other site 470137000712 Q-loop/lid; other site 470137000713 ABC transporter signature motif; other site 470137000714 Walker B; other site 470137000715 D-loop; other site 470137000716 H-loop/switch region; other site 470137000717 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 470137000718 Predicted lipoprotein involved in nitrous oxide reduction [Energy production and conversion]; Region: NosL; COG4314 470137000719 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 470137000720 ApbE family; Region: ApbE; pfam02424 470137000721 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 470137000722 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 470137000723 ligand binding site [chemical binding]; other site 470137000724 flexible hinge region; other site 470137000725 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 470137000726 putative switch regulator; other site 470137000727 non-specific DNA interactions [nucleotide binding]; other site 470137000728 DNA binding site [nucleotide binding] 470137000729 sequence specific DNA binding site [nucleotide binding]; other site 470137000730 putative cAMP binding site [chemical binding]; other site 470137000731 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 470137000732 pseudoazurin; Region: pseudoazurin; TIGR02375 470137000733 Uncharacterized protein involved in response to NO [Inorganic ion transport and metabolism]; Region: NnrS; COG3213 470137000734 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 470137000735 NMT1-like family; Region: NMT1_2; pfam13379 470137000736 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 470137000737 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 470137000738 Walker A/P-loop; other site 470137000739 ATP binding site [chemical binding]; other site 470137000740 Q-loop/lid; other site 470137000741 ABC transporter signature motif; other site 470137000742 Walker B; other site 470137000743 D-loop; other site 470137000744 H-loop/switch region; other site 470137000745 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 470137000746 putative protease; Provisional; Region: PRK15447 470137000747 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 470137000748 Peptidase family U32; Region: Peptidase_U32; pfam01136 470137000749 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 470137000750 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 470137000751 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 470137000752 Flavoprotein; Region: Flavoprotein; pfam02441 470137000753 Protein of unknown function (DUF2478); Region: DUF2478; pfam10649 470137000754 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 470137000755 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 470137000756 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 470137000757 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 470137000758 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 470137000759 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 470137000760 [4Fe-4S] binding site [ion binding]; other site 470137000761 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 470137000762 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 470137000763 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 470137000764 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 470137000765 molybdopterin cofactor binding site; other site 470137000766 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 470137000767 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 470137000768 putative substrate translocation pore; other site 470137000769 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 470137000770 transcriptional activator FtrB; Provisional; Region: ftrB; PRK09392 470137000771 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 470137000772 ligand binding site [chemical binding]; other site 470137000773 flexible hinge region; other site 470137000774 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 470137000775 Transcriptional regulators [Transcription]; Region: PurR; COG1609 470137000776 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 470137000777 DNA binding site [nucleotide binding] 470137000778 domain linker motif; other site 470137000779 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 470137000780 ligand binding site [chemical binding]; other site 470137000781 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 470137000782 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 470137000783 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 470137000784 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137000785 dimer interface [polypeptide binding]; other site 470137000786 conserved gate region; other site 470137000787 putative PBP binding loops; other site 470137000788 ABC-ATPase subunit interface; other site 470137000789 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 470137000790 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137000791 dimer interface [polypeptide binding]; other site 470137000792 conserved gate region; other site 470137000793 putative PBP binding loops; other site 470137000794 ABC-ATPase subunit interface; other site 470137000795 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 470137000796 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 470137000797 Walker A/P-loop; other site 470137000798 ATP binding site [chemical binding]; other site 470137000799 Q-loop/lid; other site 470137000800 ABC transporter signature motif; other site 470137000801 Walker B; other site 470137000802 D-loop; other site 470137000803 H-loop/switch region; other site 470137000804 TOBE domain; Region: TOBE_2; pfam08402 470137000805 Trehalose utilization protein [Carbohydrate transport and metabolism]; Region: ThuA; COG4813 470137000806 conserved cys residue [active] 470137000807 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 470137000808 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 470137000809 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 470137000810 Transmembrane secretion effector; Region: MFS_3; pfam05977 470137000811 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 470137000812 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 470137000813 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 470137000814 catalytic residues [active] 470137000815 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 470137000816 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 470137000817 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 470137000818 Class I ribonucleotide reductase; Region: RNR_I; cd01679 470137000819 active site 470137000820 dimer interface [polypeptide binding]; other site 470137000821 catalytic residues [active] 470137000822 effector binding site; other site 470137000823 R2 peptide binding site; other site 470137000824 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 470137000825 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 470137000826 dimer interface [polypeptide binding]; other site 470137000827 putative radical transfer pathway; other site 470137000828 diiron center [ion binding]; other site 470137000829 tyrosyl radical; other site 470137000830 septum formation inhibitor; Reviewed; Region: minC; PRK05177 470137000831 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 470137000832 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 470137000833 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 470137000834 Switch I; other site 470137000835 Switch II; other site 470137000836 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 470137000837 Domain of unknown function (DUF3597); Region: DUF3597; pfam12200 470137000838 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 470137000839 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 470137000840 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 470137000841 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 470137000842 Walker A/P-loop; other site 470137000843 ATP binding site [chemical binding]; other site 470137000844 Q-loop/lid; other site 470137000845 ABC transporter signature motif; other site 470137000846 Walker B; other site 470137000847 D-loop; other site 470137000848 H-loop/switch region; other site 470137000849 TOBE domain; Region: TOBE_2; pfam08402 470137000850 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137000851 dimer interface [polypeptide binding]; other site 470137000852 conserved gate region; other site 470137000853 putative PBP binding loops; other site 470137000854 ABC-ATPase subunit interface; other site 470137000855 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 470137000856 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137000857 dimer interface [polypeptide binding]; other site 470137000858 conserved gate region; other site 470137000859 putative PBP binding loops; other site 470137000860 ABC-ATPase subunit interface; other site 470137000861 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 470137000862 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 470137000863 HlyD family secretion protein; Region: HlyD_3; pfam13437 470137000864 Predicted membrane protein [Function unknown]; Region: COG4803 470137000865 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 470137000866 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 470137000867 pyridoxal 5'-phosphate binding site [chemical binding]; other site 470137000868 catalytic residue [active] 470137000869 glutaminase; Reviewed; Region: PRK12356 470137000870 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 470137000871 acid-resistance protein; Provisional; Region: PRK10208 470137000872 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 470137000873 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 470137000874 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 470137000875 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 470137000876 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 470137000877 Substrate binding site; other site 470137000878 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 470137000879 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 470137000880 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 470137000881 active site 470137000882 substrate binding site [chemical binding]; other site 470137000883 metal binding site [ion binding]; metal-binding site 470137000884 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 470137000885 putative active site pocket [active] 470137000886 cleavage site 470137000887 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 470137000888 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 470137000889 putative ion selectivity filter; other site 470137000890 putative pore gating glutamate residue; other site 470137000891 putative H+/Cl- coupling transport residue; other site 470137000892 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 470137000893 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 470137000894 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 470137000895 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 470137000896 active site 470137000897 Cytochrome c [Energy production and conversion]; Region: COG3258 470137000898 Cytochrome c; Region: Cytochrom_C; pfam00034 470137000899 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 470137000900 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 470137000901 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 470137000902 dimerization interface [polypeptide binding]; other site 470137000903 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 470137000904 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 470137000905 tetramer interface [polypeptide binding]; other site 470137000906 heme binding pocket [chemical binding]; other site 470137000907 NADPH binding site [chemical binding]; other site 470137000908 Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495 470137000909 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 470137000910 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 470137000911 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 470137000912 CoenzymeA binding site [chemical binding]; other site 470137000913 subunit interaction site [polypeptide binding]; other site 470137000914 PHB binding site; other site 470137000915 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06026 470137000916 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, putative; Region: MTA/SAH-nuc-hyp; TIGR01705 470137000917 GMP synthase; Reviewed; Region: guaA; PRK00074 470137000918 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 470137000919 AMP/PPi binding site [chemical binding]; other site 470137000920 candidate oxyanion hole; other site 470137000921 catalytic triad [active] 470137000922 potential glutamine specificity residues [chemical binding]; other site 470137000923 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 470137000924 ATP Binding subdomain [chemical binding]; other site 470137000925 Ligand Binding sites [chemical binding]; other site 470137000926 Dimerization subdomain; other site 470137000927 integrase; Provisional; Region: PRK09692 470137000928 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 470137000929 active site 470137000930 Int/Topo IB signature motif; other site 470137000931 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 470137000932 Replication initiator protein A; Region: RPA; pfam10134 470137000933 P-type conjugative transfer protein TrbL; Region: TrbL_P; TIGR02783 470137000934 P-type conjugative transfer protein TrbJ; Region: TrbJ_Ti; TIGR02780 470137000935 TraC-like protein; Region: TraC; cl06725 470137000936 conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877 470137000937 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 470137000938 conjugal transfer relaxase TraI; Provisional; Region: PRK13878 470137000939 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 470137000940 Predicted ATPase [General function prediction only]; Region: COG5293 470137000941 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 470137000942 DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077 470137000943 Uncharacterized protein probably involved in high-affinity Fe2+ transport [Inorganic ion transport and metabolism]; Region: Tpd; COG3470 470137000944 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 470137000945 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 470137000946 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 470137000947 4Fe-4S binding domain; Region: Fer4_5; pfam12801 470137000948 putative phosphoketolase; Provisional; Region: PRK05261 470137000949 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 470137000950 TPP-binding site; other site 470137000951 XFP C-terminal domain; Region: XFP_C; pfam09363 470137000952 acetate kinase; Provisional; Region: PRK07058 470137000953 propionate/acetate kinase; Provisional; Region: PRK12379 470137000954 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 470137000955 Cytochrome P450; Region: p450; cl12078 470137000956 Transcriptional regulators [Transcription]; Region: GntR; COG1802 470137000957 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 470137000958 DNA-binding site [nucleotide binding]; DNA binding site 470137000959 FCD domain; Region: FCD; pfam07729 470137000960 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 470137000961 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 470137000962 NAD(P) binding site [chemical binding]; other site 470137000963 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 470137000964 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 470137000965 NAD(P) binding site [chemical binding]; other site 470137000966 active site 470137000967 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 470137000968 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 470137000969 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 470137000970 shikimate binding site; other site 470137000971 NAD(P) binding site [chemical binding]; other site 470137000972 choline dehydrogenase; Validated; Region: PRK02106 470137000973 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 470137000974 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 470137000975 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 470137000976 tetramerization interface [polypeptide binding]; other site 470137000977 NAD(P) binding site [chemical binding]; other site 470137000978 catalytic residues [active] 470137000979 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 470137000980 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 470137000981 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 470137000982 Zinc-dependent alcohol dehydrogenases (ADH) and class III ADG (AKA formaldehyde dehydrogenase); Region: liver_ADH_like1; cd08281 470137000983 NAD binding site [chemical binding]; other site 470137000984 catalytic Zn binding site [ion binding]; other site 470137000985 substrate binding site [chemical binding]; other site 470137000986 structural Zn binding site [ion binding]; other site 470137000987 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 470137000988 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 470137000989 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 470137000990 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 470137000991 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 470137000992 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 470137000993 Walker A/P-loop; other site 470137000994 ATP binding site [chemical binding]; other site 470137000995 Q-loop/lid; other site 470137000996 ABC transporter signature motif; other site 470137000997 Walker B; other site 470137000998 D-loop; other site 470137000999 H-loop/switch region; other site 470137001000 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 470137001001 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 470137001002 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 470137001003 Walker A/P-loop; other site 470137001004 ATP binding site [chemical binding]; other site 470137001005 Q-loop/lid; other site 470137001006 ABC transporter signature motif; other site 470137001007 Walker B; other site 470137001008 D-loop; other site 470137001009 H-loop/switch region; other site 470137001010 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 470137001011 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 470137001012 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 470137001013 inhibitor site; inhibition site 470137001014 active site 470137001015 dimer interface [polypeptide binding]; other site 470137001016 catalytic residue [active] 470137001017 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 470137001018 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137001019 dimer interface [polypeptide binding]; other site 470137001020 conserved gate region; other site 470137001021 putative PBP binding loops; other site 470137001022 ABC-ATPase subunit interface; other site 470137001023 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 470137001024 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137001025 dimer interface [polypeptide binding]; other site 470137001026 conserved gate region; other site 470137001027 putative PBP binding loops; other site 470137001028 ABC-ATPase subunit interface; other site 470137001029 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 470137001030 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 470137001031 Transcriptional regulators [Transcription]; Region: FadR; COG2186 470137001032 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 470137001033 DNA-binding site [nucleotide binding]; DNA binding site 470137001034 FCD domain; Region: FCD; pfam07729 470137001035 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 470137001036 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 470137001037 putative active site cavity [active] 470137001038 N-acetylmannosamine kinase; Provisional; Region: PRK05082 470137001039 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 470137001040 nucleotide binding site [chemical binding]; other site 470137001041 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 470137001042 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 470137001043 Chain length determinant protein; Region: Wzz; cl15801 470137001044 AAA domain; Region: AAA_31; pfam13614 470137001045 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 470137001046 G3 box; other site 470137001047 Switch II region; other site 470137001048 G4 box; other site 470137001049 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 470137001050 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 470137001051 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 470137001052 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 470137001053 NADP binding site [chemical binding]; other site 470137001054 active site 470137001055 putative substrate binding site [chemical binding]; other site 470137001056 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 470137001057 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 470137001058 NADP-binding site; other site 470137001059 homotetramer interface [polypeptide binding]; other site 470137001060 substrate binding site [chemical binding]; other site 470137001061 homodimer interface [polypeptide binding]; other site 470137001062 active site 470137001063 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 470137001064 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 470137001065 putative ADP-binding pocket [chemical binding]; other site 470137001066 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 470137001067 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 470137001068 putative trimer interface [polypeptide binding]; other site 470137001069 putative active site [active] 470137001070 putative substrate binding site [chemical binding]; other site 470137001071 putative CoA binding site [chemical binding]; other site 470137001072 Uncharacterized conserved protein [Function unknown]; Region: COG1434 470137001073 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 470137001074 putative active site [active] 470137001075 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 470137001076 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 470137001077 putative metal binding site; other site 470137001078 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 470137001079 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 470137001080 Mg++ binding site [ion binding]; other site 470137001081 putative catalytic motif [active] 470137001082 substrate binding site [chemical binding]; other site 470137001083 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 470137001084 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 470137001085 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 470137001086 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 470137001087 active site 470137001088 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 470137001089 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 470137001090 glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209 470137001091 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 470137001092 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 470137001093 catalytic residue [active] 470137001094 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 470137001095 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 470137001096 extended (e) SDRs; Region: SDR_e; cd08946 470137001097 NAD(P) binding site [chemical binding]; other site 470137001098 active site 470137001099 substrate binding site [chemical binding]; other site 470137001100 Uncharacterized protein conserved in bacteria with an aminopeptidase-like domain [General function prediction only]; Region: COG4310 470137001101 M28 Zn-Peptidases; Region: M28_like_3; cd05644 470137001102 active site 470137001103 metal binding site [ion binding]; metal-binding site 470137001104 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 470137001105 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 470137001106 Methyltransferase domain; Region: Methyltransf_23; pfam13489 470137001107 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 470137001108 S-adenosylmethionine binding site [chemical binding]; other site 470137001109 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 470137001110 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 470137001111 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 470137001112 active site 470137001113 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 470137001114 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 470137001115 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 470137001116 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 470137001117 N- and C-terminal domain interface [polypeptide binding]; other site 470137001118 active site 470137001119 MgATP binding site [chemical binding]; other site 470137001120 catalytic site [active] 470137001121 metal binding site [ion binding]; metal-binding site 470137001122 glycerol binding site [chemical binding]; other site 470137001123 homotetramer interface [polypeptide binding]; other site 470137001124 homodimer interface [polypeptide binding]; other site 470137001125 FBP binding site [chemical binding]; other site 470137001126 protein IIAGlc interface [polypeptide binding]; other site 470137001127 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 470137001128 Major Facilitator Superfamily; Region: MFS_1; pfam07690 470137001129 putative substrate translocation pore; other site 470137001130 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 470137001131 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 470137001132 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 470137001133 putative dimerization interface [polypeptide binding]; other site 470137001134 putative substrate binding pocket [chemical binding]; other site 470137001135 methionine sulfoxide reductase B; Provisional; Region: PRK00222 470137001136 SelR domain; Region: SelR; pfam01641 470137001137 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 470137001138 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 470137001139 active site 470137001140 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 470137001141 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 470137001142 dimer interface [polypeptide binding]; other site 470137001143 active site 470137001144 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 470137001145 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 470137001146 NAD binding site [chemical binding]; other site 470137001147 homodimer interface [polypeptide binding]; other site 470137001148 homotetramer interface [polypeptide binding]; other site 470137001149 active site 470137001150 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 470137001151 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_2; cd05973 470137001152 active site 470137001153 acyl-activating enzyme (AAE) consensus motif; other site 470137001154 putative CoA binding site [chemical binding]; other site 470137001155 AMP binding site [chemical binding]; other site 470137001156 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 470137001157 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 470137001158 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 470137001159 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 470137001160 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 470137001161 ligand binding site [chemical binding]; other site 470137001162 NAD binding site [chemical binding]; other site 470137001163 tetramer interface [polypeptide binding]; other site 470137001164 catalytic site [active] 470137001165 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 470137001166 L-serine binding site [chemical binding]; other site 470137001167 ACT domain interface; other site 470137001168 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 470137001169 active site 470137001170 catalytic residues [active] 470137001171 metal binding site [ion binding]; metal-binding site 470137001172 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 470137001173 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 470137001174 dimerization interface [polypeptide binding]; other site 470137001175 putative DNA binding site [nucleotide binding]; other site 470137001176 putative Zn2+ binding site [ion binding]; other site 470137001177 Predicted transporter component [General function prediction only]; Region: COG2391 470137001178 Predicted transporter component [General function prediction only]; Region: COG2391 470137001179 Sulphur transport; Region: Sulf_transp; pfam04143 470137001180 Transcriptional regulators [Transcription]; Region: GntR; COG1802 470137001181 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 470137001182 DNA-binding site [nucleotide binding]; DNA binding site 470137001183 FCD domain; Region: FCD; pfam07729 470137001184 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 470137001185 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 470137001186 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 470137001187 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 470137001188 Peptidase family M23; Region: Peptidase_M23; pfam01551 470137001189 HlyD family secretion protein; Region: HlyD_3; pfam13437 470137001190 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 470137001191 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 470137001192 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 470137001193 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 470137001194 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 470137001195 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137001196 dimer interface [polypeptide binding]; other site 470137001197 conserved gate region; other site 470137001198 putative PBP binding loops; other site 470137001199 ABC-ATPase subunit interface; other site 470137001200 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 470137001201 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 470137001202 Walker A/P-loop; other site 470137001203 ATP binding site [chemical binding]; other site 470137001204 Q-loop/lid; other site 470137001205 ABC transporter signature motif; other site 470137001206 Walker B; other site 470137001207 D-loop; other site 470137001208 H-loop/switch region; other site 470137001209 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 470137001210 NMT1/THI5 like; Region: NMT1; pfam09084 470137001211 substrate binding pocket [chemical binding]; other site 470137001212 membrane-bound complex binding site; other site 470137001213 hinge residues; other site 470137001214 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 470137001215 putative substrate translocation pore; other site 470137001216 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 470137001217 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 470137001218 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 470137001219 HlyD family secretion protein; Region: HlyD_3; pfam13437 470137001220 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 470137001221 HAMP domain; Region: HAMP; pfam00672 470137001222 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 470137001223 dimer interface [polypeptide binding]; other site 470137001224 phosphorylation site [posttranslational modification] 470137001225 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 470137001226 ATP binding site [chemical binding]; other site 470137001227 Mg2+ binding site [ion binding]; other site 470137001228 G-X-G motif; other site 470137001229 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 470137001230 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 470137001231 active site 470137001232 phosphorylation site [posttranslational modification] 470137001233 intermolecular recognition site; other site 470137001234 dimerization interface [polypeptide binding]; other site 470137001235 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 470137001236 DNA binding site [nucleotide binding] 470137001237 Uncharacterized conserved protein [Function unknown]; Region: COG3189 470137001238 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 470137001239 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 470137001240 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 470137001241 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 470137001242 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 470137001243 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 470137001244 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 470137001245 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 470137001246 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 470137001247 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 470137001248 Homoserine trans-succinylase [Amino acid transport and metabolism]; Region: MetA; COG1897 470137001249 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 470137001250 proposed active site lysine [active] 470137001251 conserved cys residue [active] 470137001252 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 470137001253 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 470137001254 active site 470137001255 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05963 470137001256 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 470137001257 dimer interface [polypeptide binding]; other site 470137001258 active site 470137001259 CoA binding pocket [chemical binding]; other site 470137001260 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 470137001261 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 470137001262 inhibitor-cofactor binding pocket; inhibition site 470137001263 pyridoxal 5'-phosphate binding site [chemical binding]; other site 470137001264 catalytic residue [active] 470137001265 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 470137001266 AAA domain; Region: AAA_26; pfam13500 470137001267 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 470137001268 hypothetical protein; Provisional; Region: PRK07505 470137001269 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 470137001270 catalytic residue [active] 470137001271 biotin synthase; Region: bioB; TIGR00433 470137001272 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 470137001273 FeS/SAM binding site; other site 470137001274 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 470137001275 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 470137001276 MPT binding site; other site 470137001277 trimer interface [polypeptide binding]; other site 470137001278 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 470137001279 dimer interface [polypeptide binding]; other site 470137001280 FMN binding site [chemical binding]; other site 470137001281 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 470137001282 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 470137001283 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 470137001284 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 470137001285 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 470137001286 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 470137001287 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 470137001288 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 470137001289 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 470137001290 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 470137001291 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12596 470137001292 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 470137001293 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12671 470137001294 Predicted transcriptional regulators [Transcription]; Region: COG1510 470137001295 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 470137001296 dimerization interface [polypeptide binding]; other site 470137001297 putative DNA binding site [nucleotide binding]; other site 470137001298 putative Zn2+ binding site [ion binding]; other site 470137001299 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 470137001300 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 470137001301 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 470137001302 Walker A/P-loop; other site 470137001303 ATP binding site [chemical binding]; other site 470137001304 Q-loop/lid; other site 470137001305 ABC transporter signature motif; other site 470137001306 Walker B; other site 470137001307 D-loop; other site 470137001308 H-loop/switch region; other site 470137001309 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 470137001310 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 470137001311 Walker A/P-loop; other site 470137001312 ATP binding site [chemical binding]; other site 470137001313 Q-loop/lid; other site 470137001314 ABC transporter signature motif; other site 470137001315 Walker B; other site 470137001316 D-loop; other site 470137001317 H-loop/switch region; other site 470137001318 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 470137001319 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 470137001320 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 470137001321 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 470137001322 Predicted outer membrane lipoprotein [Function unknown]; Region: COG4890 470137001323 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 470137001324 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 470137001325 DNA-binding site [nucleotide binding]; DNA binding site 470137001326 UTRA domain; Region: UTRA; pfam07702 470137001327 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 470137001328 nucleotide binding site [chemical binding]; other site 470137001329 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 470137001330 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 470137001331 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 470137001332 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137001333 dimer interface [polypeptide binding]; other site 470137001334 conserved gate region; other site 470137001335 putative PBP binding loops; other site 470137001336 ABC-ATPase subunit interface; other site 470137001337 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 470137001338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137001339 dimer interface [polypeptide binding]; other site 470137001340 conserved gate region; other site 470137001341 putative PBP binding loops; other site 470137001342 ABC-ATPase subunit interface; other site 470137001343 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 470137001344 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 470137001345 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 470137001346 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 470137001347 Walker A/P-loop; other site 470137001348 ATP binding site [chemical binding]; other site 470137001349 Q-loop/lid; other site 470137001350 ABC transporter signature motif; other site 470137001351 Walker B; other site 470137001352 D-loop; other site 470137001353 H-loop/switch region; other site 470137001354 TOBE domain; Region: TOBE_2; pfam08402 470137001355 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573 470137001356 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 470137001357 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 470137001358 tetramer interface [polypeptide binding]; other site 470137001359 TPP-binding site [chemical binding]; other site 470137001360 heterodimer interface [polypeptide binding]; other site 470137001361 phosphorylation loop region [posttranslational modification] 470137001362 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 470137001363 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 470137001364 alpha subunit interface [polypeptide binding]; other site 470137001365 TPP binding site [chemical binding]; other site 470137001366 heterodimer interface [polypeptide binding]; other site 470137001367 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 470137001368 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 470137001369 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 470137001370 E3 interaction surface; other site 470137001371 lipoyl attachment site [posttranslational modification]; other site 470137001372 e3 binding domain; Region: E3_binding; pfam02817 470137001373 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 470137001374 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 470137001375 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 470137001376 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 470137001377 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 470137001378 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 470137001379 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 470137001380 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 470137001381 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 470137001382 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 470137001383 homodimer interface [polypeptide binding]; other site 470137001384 homotetramer interface [polypeptide binding]; other site 470137001385 active site pocket [active] 470137001386 cleavage site 470137001387 benzoate transport; Region: 2A0115; TIGR00895 470137001388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 470137001389 putative substrate translocation pore; other site 470137001390 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 470137001391 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 470137001392 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 470137001393 Walker A/P-loop; other site 470137001394 ATP binding site [chemical binding]; other site 470137001395 Q-loop/lid; other site 470137001396 ABC transporter signature motif; other site 470137001397 Walker B; other site 470137001398 D-loop; other site 470137001399 H-loop/switch region; other site 470137001400 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 470137001401 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 470137001402 Walker A/P-loop; other site 470137001403 ATP binding site [chemical binding]; other site 470137001404 Q-loop/lid; other site 470137001405 ABC transporter signature motif; other site 470137001406 Walker B; other site 470137001407 D-loop; other site 470137001408 H-loop/switch region; other site 470137001409 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 470137001410 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 470137001411 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137001412 dimer interface [polypeptide binding]; other site 470137001413 conserved gate region; other site 470137001414 ABC-ATPase subunit interface; other site 470137001415 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 470137001416 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137001417 dimer interface [polypeptide binding]; other site 470137001418 conserved gate region; other site 470137001419 putative PBP binding loops; other site 470137001420 ABC-ATPase subunit interface; other site 470137001421 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 470137001422 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 470137001423 peptide binding site [polypeptide binding]; other site 470137001424 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 470137001425 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 470137001426 peptide binding site [polypeptide binding]; other site 470137001427 Predicted integral membrane protein [Function unknown]; Region: COG5455 470137001428 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 470137001429 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 470137001430 NAD binding site [chemical binding]; other site 470137001431 putative substrate binding site 2 [chemical binding]; other site 470137001432 putative substrate binding site 1 [chemical binding]; other site 470137001433 active site 470137001434 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 470137001435 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 470137001436 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 470137001437 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 470137001438 Protein of unknown function (DUF995); Region: DUF995; pfam06191 470137001439 Protein of unknown function (DUF995); Region: DUF995; pfam06191 470137001440 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 470137001441 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 470137001442 yecA family protein; Region: ygfB_yecA; TIGR02292 470137001443 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 470137001444 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 470137001445 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 470137001446 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 470137001447 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 470137001448 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 470137001449 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 470137001450 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 470137001451 Transposase; Region: HTH_Tnp_1; pfam01527 470137001452 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 470137001453 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 470137001454 putative deacylase active site [active] 470137001455 iron-responsive transcriptional regulator; Reviewed; Region: rirA; PRK11920 470137001456 Predicted transcriptional regulator [Transcription]; Region: COG1959 470137001457 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 470137001458 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 470137001459 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 470137001460 heme binding site [chemical binding]; other site 470137001461 ferroxidase pore; other site 470137001462 ferroxidase diiron center [ion binding]; other site 470137001463 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 470137001464 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 470137001465 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 470137001466 FeS/SAM binding site; other site 470137001467 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 470137001468 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 470137001469 putative ligand binding site [chemical binding]; other site 470137001470 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 470137001471 TM-ABC transporter signature motif; other site 470137001472 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 470137001473 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 470137001474 TM-ABC transporter signature motif; other site 470137001475 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 470137001476 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 470137001477 Walker A/P-loop; other site 470137001478 ATP binding site [chemical binding]; other site 470137001479 Q-loop/lid; other site 470137001480 ABC transporter signature motif; other site 470137001481 Walker B; other site 470137001482 D-loop; other site 470137001483 H-loop/switch region; other site 470137001484 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 470137001485 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 470137001486 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 470137001487 NADP binding site [chemical binding]; other site 470137001488 dimer interface [polypeptide binding]; other site 470137001489 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 470137001490 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 470137001491 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494 470137001492 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 470137001493 Uncharacterized conserved protein [Function unknown]; Region: COG3785 470137001494 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 470137001495 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 470137001496 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 470137001497 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 470137001498 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 470137001499 catalytic residues [active] 470137001500 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 470137001501 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 470137001502 active site 470137001503 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 470137001504 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 470137001505 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 470137001506 ATP binding site [chemical binding]; other site 470137001507 putative Mg++ binding site [ion binding]; other site 470137001508 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 470137001509 nucleotide binding region [chemical binding]; other site 470137001510 ATP-binding site [chemical binding]; other site 470137001511 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 470137001512 Uncharacterized conserved protein [Function unknown]; Region: COG2938 470137001513 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 470137001514 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 470137001515 generic binding surface II; other site 470137001516 ssDNA binding site; other site 470137001517 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 470137001518 ATP binding site [chemical binding]; other site 470137001519 putative Mg++ binding site [ion binding]; other site 470137001520 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 470137001521 nucleotide binding region [chemical binding]; other site 470137001522 ATP-binding site [chemical binding]; other site 470137001523 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 470137001524 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 470137001525 glutaminase active site [active] 470137001526 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 470137001527 dimer interface [polypeptide binding]; other site 470137001528 active site 470137001529 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 470137001530 dimer interface [polypeptide binding]; other site 470137001531 active site 470137001532 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 470137001533 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 470137001534 Substrate binding site; other site 470137001535 Mg++ binding site; other site 470137001536 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 470137001537 active site 470137001538 substrate binding site [chemical binding]; other site 470137001539 CoA binding site [chemical binding]; other site 470137001540 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 470137001541 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 470137001542 Predicted integral membrane protein [Function unknown]; Region: COG0392 470137001543 Uncharacterized conserved protein [Function unknown]; Region: COG2898 470137001544 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 470137001545 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 470137001546 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 470137001547 BA14K-like protein; Region: BA14K; pfam07886 470137001548 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 470137001549 PAS domain; Region: PAS_9; pfam13426 470137001550 putative active site [active] 470137001551 heme pocket [chemical binding]; other site 470137001552 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 470137001553 PAS fold; Region: PAS_3; pfam08447 470137001554 putative active site [active] 470137001555 heme pocket [chemical binding]; other site 470137001556 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 470137001557 HWE histidine kinase; Region: HWE_HK; pfam07536 470137001558 lipoate-protein ligase B; Provisional; Region: PRK14341 470137001559 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 470137001560 EamA-like transporter family; Region: EamA; pfam00892 470137001561 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 470137001562 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 470137001563 Mg2+ binding site [ion binding]; other site 470137001564 G-X-G motif; other site 470137001565 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 470137001566 anchoring element; other site 470137001567 dimer interface [polypeptide binding]; other site 470137001568 ATP binding site [chemical binding]; other site 470137001569 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 470137001570 active site 470137001571 metal binding site [ion binding]; metal-binding site 470137001572 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 470137001573 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 470137001574 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 470137001575 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 470137001576 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 470137001577 metal-dependent hydrolase; Provisional; Region: PRK00685 470137001578 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 470137001579 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 470137001580 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 470137001581 active site 470137001582 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 470137001583 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 470137001584 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 470137001585 dihydroorotase; Validated; Region: PRK09059 470137001586 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 470137001587 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 470137001588 active site 470137001589 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 470137001590 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 470137001591 DNA protecting protein DprA; Region: dprA; TIGR00732 470137001592 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 470137001593 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 470137001594 active site 470137001595 interdomain interaction site; other site 470137001596 putative metal-binding site [ion binding]; other site 470137001597 nucleotide binding site [chemical binding]; other site 470137001598 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 470137001599 domain I; other site 470137001600 DNA binding groove [nucleotide binding] 470137001601 phosphate binding site [ion binding]; other site 470137001602 domain II; other site 470137001603 domain III; other site 470137001604 nucleotide binding site [chemical binding]; other site 470137001605 catalytic site [active] 470137001606 domain IV; other site 470137001607 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 470137001608 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 470137001609 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 470137001610 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 470137001611 ribonuclease R; Region: RNase_R; TIGR02063 470137001612 RNB domain; Region: RNB; pfam00773 470137001613 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 470137001614 RNA binding site [nucleotide binding]; other site 470137001615 hypothetical protein; Provisional; Region: PRK05978 470137001616 Major Facilitator Superfamily; Region: MFS_1; pfam07690 470137001617 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 470137001618 putative substrate translocation pore; other site 470137001619 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 470137001620 response regulator PleD; Reviewed; Region: pleD; PRK09581 470137001621 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 470137001622 active site 470137001623 phosphorylation site [posttranslational modification] 470137001624 intermolecular recognition site; other site 470137001625 dimerization interface [polypeptide binding]; other site 470137001626 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 470137001627 active site 470137001628 phosphorylation site [posttranslational modification] 470137001629 intermolecular recognition site; other site 470137001630 dimerization interface [polypeptide binding]; other site 470137001631 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 470137001632 metal binding site [ion binding]; metal-binding site 470137001633 active site 470137001634 I-site; other site 470137001635 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 470137001636 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 470137001637 active site 470137001638 phosphorylation site [posttranslational modification] 470137001639 intermolecular recognition site; other site 470137001640 dimerization interface [polypeptide binding]; other site 470137001641 Protein of unknown function (DUF3572); Region: DUF3572; pfam12096 470137001642 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 470137001643 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 470137001644 DNA polymerase IV; Provisional; Region: PRK02794 470137001645 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 470137001646 active site 470137001647 DNA binding site [nucleotide binding] 470137001648 Uncharacterized conserved protein [Function unknown]; Region: COG3391 470137001649 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 470137001650 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 470137001651 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 470137001652 metal binding site [ion binding]; metal-binding site 470137001653 active site 470137001654 I-site; other site 470137001655 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 470137001656 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 470137001657 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 470137001658 active site 470137001659 catalytic site [active] 470137001660 substrate binding site [chemical binding]; other site 470137001661 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 470137001662 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 470137001663 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 470137001664 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 470137001665 hydroxyglutarate oxidase; Provisional; Region: PRK11728 470137001666 hydroxyglutarate oxidase; Provisional; Region: PRK11728 470137001667 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 470137001668 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 470137001669 substrate binding pocket [chemical binding]; other site 470137001670 membrane-bound complex binding site; other site 470137001671 hinge residues; other site 470137001672 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 470137001673 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 470137001674 substrate binding pocket [chemical binding]; other site 470137001675 membrane-bound complex binding site; other site 470137001676 hinge residues; other site 470137001677 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 470137001678 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 470137001679 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 470137001680 putative DNA binding site [nucleotide binding]; other site 470137001681 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 470137001682 putative Zn2+ binding site [ion binding]; other site 470137001683 AsnC family; Region: AsnC_trans_reg; pfam01037 470137001684 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 470137001685 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 470137001686 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 470137001687 TM-ABC transporter signature motif; other site 470137001688 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 470137001689 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 470137001690 Walker A/P-loop; other site 470137001691 ATP binding site [chemical binding]; other site 470137001692 Q-loop/lid; other site 470137001693 ABC transporter signature motif; other site 470137001694 Walker B; other site 470137001695 D-loop; other site 470137001696 H-loop/switch region; other site 470137001697 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 470137001698 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 470137001699 Walker A/P-loop; other site 470137001700 ATP binding site [chemical binding]; other site 470137001701 Q-loop/lid; other site 470137001702 ABC transporter signature motif; other site 470137001703 Walker B; other site 470137001704 D-loop; other site 470137001705 H-loop/switch region; other site 470137001706 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 470137001707 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 470137001708 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 470137001709 active site 470137001710 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 470137001711 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 470137001712 active site 470137001713 dimer interface [polypeptide binding]; other site 470137001714 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 470137001715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 470137001716 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 470137001717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137001718 dimer interface [polypeptide binding]; other site 470137001719 conserved gate region; other site 470137001720 ABC-ATPase subunit interface; other site 470137001721 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 470137001722 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 470137001723 Walker A/P-loop; other site 470137001724 ATP binding site [chemical binding]; other site 470137001725 Q-loop/lid; other site 470137001726 ABC transporter signature motif; other site 470137001727 Walker B; other site 470137001728 D-loop; other site 470137001729 H-loop/switch region; other site 470137001730 TOBE domain; Region: TOBE_2; pfam08402 470137001731 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 470137001732 nucleoside/Zn binding site; other site 470137001733 dimer interface [polypeptide binding]; other site 470137001734 catalytic motif [active] 470137001735 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 470137001736 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 470137001737 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 470137001738 EamA-like transporter family; Region: EamA; pfam00892 470137001739 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 470137001740 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 470137001741 FAD binding domain; Region: FAD_binding_2; pfam00890 470137001742 Protein of unknown function (DUF3775); Region: DUF3775; pfam12616 470137001743 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 470137001744 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 470137001745 putative ligand binding residues [chemical binding]; other site 470137001746 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 470137001747 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 470137001748 ABC-ATPase subunit interface; other site 470137001749 dimer interface [polypeptide binding]; other site 470137001750 putative PBP binding regions; other site 470137001751 ABC-type enterochelin transport system, permease component [Inorganic ion transport and metabolism]; Region: CeuC; COG4605 470137001752 ABC-ATPase subunit interface; other site 470137001753 dimer interface [polypeptide binding]; other site 470137001754 putative PBP binding regions; other site 470137001755 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 470137001756 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 470137001757 Walker A/P-loop; other site 470137001758 ATP binding site [chemical binding]; other site 470137001759 Q-loop/lid; other site 470137001760 ABC transporter signature motif; other site 470137001761 Walker B; other site 470137001762 D-loop; other site 470137001763 H-loop/switch region; other site 470137001764 Predicted transcription regulator, contains HTH domain (MarR family) [Transcription]; Region: COG5631 470137001765 5-oxoprolinase; Region: PLN02666 470137001766 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 470137001767 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 470137001768 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 470137001769 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 470137001770 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 470137001771 substrate binding pocket [chemical binding]; other site 470137001772 membrane-bound complex binding site; other site 470137001773 hinge residues; other site 470137001774 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137001775 dimer interface [polypeptide binding]; other site 470137001776 conserved gate region; other site 470137001777 putative PBP binding loops; other site 470137001778 ABC-ATPase subunit interface; other site 470137001779 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 470137001780 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 470137001781 Walker A/P-loop; other site 470137001782 ATP binding site [chemical binding]; other site 470137001783 Q-loop/lid; other site 470137001784 ABC transporter signature motif; other site 470137001785 Walker B; other site 470137001786 D-loop; other site 470137001787 H-loop/switch region; other site 470137001788 exopolyphosphatase; Region: exo_poly_only; TIGR03706 470137001789 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 470137001790 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 470137001791 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 470137001792 S-adenosylmethionine binding site [chemical binding]; other site 470137001793 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 470137001794 putative transporter; Provisional; Region: PRK10504 470137001795 putative substrate translocation pore; other site 470137001796 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 470137001797 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 470137001798 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 470137001799 Walker A/P-loop; other site 470137001800 ATP binding site [chemical binding]; other site 470137001801 Q-loop/lid; other site 470137001802 ABC transporter signature motif; other site 470137001803 Walker B; other site 470137001804 D-loop; other site 470137001805 H-loop/switch region; other site 470137001806 TOBE domain; Region: TOBE_2; pfam08402 470137001807 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 470137001808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137001809 dimer interface [polypeptide binding]; other site 470137001810 conserved gate region; other site 470137001811 putative PBP binding loops; other site 470137001812 ABC-ATPase subunit interface; other site 470137001813 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137001814 dimer interface [polypeptide binding]; other site 470137001815 conserved gate region; other site 470137001816 putative PBP binding loops; other site 470137001817 ABC-ATPase subunit interface; other site 470137001818 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 470137001819 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 470137001820 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-II; Region: Lumazine_synthase-II; cd09208 470137001821 active site 470137001822 homopentamer interface [polypeptide binding]; other site 470137001823 dimer interface [polypeptide binding]; other site 470137001824 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 470137001825 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3453 470137001826 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 470137001827 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137001828 dimer interface [polypeptide binding]; other site 470137001829 conserved gate region; other site 470137001830 putative PBP binding loops; other site 470137001831 ABC-ATPase subunit interface; other site 470137001832 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137001833 dimer interface [polypeptide binding]; other site 470137001834 conserved gate region; other site 470137001835 putative PBP binding loops; other site 470137001836 ABC-ATPase subunit interface; other site 470137001837 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 470137001838 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 470137001839 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 470137001840 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 470137001841 Walker A/P-loop; other site 470137001842 ATP binding site [chemical binding]; other site 470137001843 Q-loop/lid; other site 470137001844 ABC transporter signature motif; other site 470137001845 Walker B; other site 470137001846 D-loop; other site 470137001847 H-loop/switch region; other site 470137001848 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 470137001849 hydroxyglutarate oxidase; Provisional; Region: PRK11728 470137001850 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 470137001851 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 470137001852 E-class dimer interface [polypeptide binding]; other site 470137001853 P-class dimer interface [polypeptide binding]; other site 470137001854 active site 470137001855 Cu2+ binding site [ion binding]; other site 470137001856 Zn2+ binding site [ion binding]; other site 470137001857 multicopper oxidase; Provisional; Region: PRK10965 470137001858 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 470137001859 Multicopper oxidase; Region: Cu-oxidase; pfam00394 470137001860 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 470137001861 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 470137001862 metabolite-proton symporter; Region: 2A0106; TIGR00883 470137001863 putative substrate translocation pore; other site 470137001864 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 470137001865 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 470137001866 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 470137001867 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 470137001868 dimer interface [polypeptide binding]; other site 470137001869 decamer (pentamer of dimers) interface [polypeptide binding]; other site 470137001870 catalytic triad [active] 470137001871 peroxidatic and resolving cysteines [active] 470137001872 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 470137001873 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 470137001874 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 470137001875 dimerization interface [polypeptide binding]; other site 470137001876 Protein of unknown function (DUF1612); Region: DUF1612; pfam07756 470137001877 HTH DNA binding domain; Region: HTH_13; pfam11972 470137001878 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 470137001879 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 470137001880 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 470137001881 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 470137001882 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 470137001883 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 470137001884 putative active site [active] 470137001885 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 470137001886 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 470137001887 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 470137001888 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 470137001889 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 470137001890 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 470137001891 active site 470137001892 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 470137001893 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 470137001894 Walker A/P-loop; other site 470137001895 ATP binding site [chemical binding]; other site 470137001896 Q-loop/lid; other site 470137001897 ABC transporter signature motif; other site 470137001898 Walker B; other site 470137001899 D-loop; other site 470137001900 H-loop/switch region; other site 470137001901 TOBE domain; Region: TOBE_2; pfam08402 470137001902 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 470137001903 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137001904 dimer interface [polypeptide binding]; other site 470137001905 conserved gate region; other site 470137001906 putative PBP binding loops; other site 470137001907 ABC-ATPase subunit interface; other site 470137001908 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137001909 dimer interface [polypeptide binding]; other site 470137001910 conserved gate region; other site 470137001911 putative PBP binding loops; other site 470137001912 ABC-ATPase subunit interface; other site 470137001913 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 470137001914 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 470137001915 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 470137001916 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 470137001917 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 470137001918 Glutamate binding site [chemical binding]; other site 470137001919 NAD binding site [chemical binding]; other site 470137001920 catalytic residues [active] 470137001921 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 470137001922 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 470137001923 putative DNA binding site [nucleotide binding]; other site 470137001924 putative Zn2+ binding site [ion binding]; other site 470137001925 AsnC family; Region: AsnC_trans_reg; pfam01037 470137001926 glycine dehydrogenase; Provisional; Region: PRK05367 470137001927 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 470137001928 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 470137001929 catalytic residue [active] 470137001930 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 470137001931 tetramer interface [polypeptide binding]; other site 470137001932 pyridoxal 5'-phosphate binding site [chemical binding]; other site 470137001933 catalytic residue [active] 470137001934 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 470137001935 lipoyl attachment site [posttranslational modification]; other site 470137001936 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 470137001937 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 470137001938 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 470137001939 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 470137001940 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 470137001941 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 470137001942 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 470137001943 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 470137001944 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 470137001945 putative active site [active] 470137001946 Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931 470137001947 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 470137001948 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 470137001949 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 470137001950 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 470137001951 putative active site [active] 470137001952 metal binding site [ion binding]; metal-binding site 470137001953 BA14K-like protein; Region: BA14K; pfam07886 470137001954 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 470137001955 EamA-like transporter family; Region: EamA; pfam00892 470137001956 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 470137001957 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 470137001958 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137001959 dimer interface [polypeptide binding]; other site 470137001960 conserved gate region; other site 470137001961 putative PBP binding loops; other site 470137001962 ABC-ATPase subunit interface; other site 470137001963 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 470137001964 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 470137001965 Walker A/P-loop; other site 470137001966 ATP binding site [chemical binding]; other site 470137001967 Q-loop/lid; other site 470137001968 ABC transporter signature motif; other site 470137001969 Walker B; other site 470137001970 D-loop; other site 470137001971 H-loop/switch region; other site 470137001972 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 470137001973 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 470137001974 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 470137001975 dimer interface [polypeptide binding]; other site 470137001976 active site 470137001977 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 470137001978 substrate binding site [chemical binding]; other site 470137001979 catalytic residue [active] 470137001980 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 470137001981 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 470137001982 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 470137001983 putative active site [active] 470137001984 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 470137001985 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 470137001986 Walker A/P-loop; other site 470137001987 ATP binding site [chemical binding]; other site 470137001988 Q-loop/lid; other site 470137001989 ABC transporter signature motif; other site 470137001990 Walker B; other site 470137001991 D-loop; other site 470137001992 H-loop/switch region; other site 470137001993 TOBE domain; Region: TOBE; pfam03459 470137001994 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 470137001995 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 470137001996 NAD(P) binding site [chemical binding]; other site 470137001997 active site 470137001998 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 470137001999 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 470137002000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137002001 dimer interface [polypeptide binding]; other site 470137002002 conserved gate region; other site 470137002003 putative PBP binding loops; other site 470137002004 ABC-ATPase subunit interface; other site 470137002005 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 470137002006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137002007 dimer interface [polypeptide binding]; other site 470137002008 conserved gate region; other site 470137002009 putative PBP binding loops; other site 470137002010 ABC-ATPase subunit interface; other site 470137002011 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 470137002012 homotrimer interaction site [polypeptide binding]; other site 470137002013 putative active site [active] 470137002014 Uncharacterized conserved protein [Function unknown]; Region: COG5476 470137002015 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 470137002016 MlrC C-terminus; Region: MlrC_C; pfam07171 470137002017 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 470137002018 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 470137002019 ABC-ATPase subunit interface; other site 470137002020 dimer interface [polypeptide binding]; other site 470137002021 putative PBP binding regions; other site 470137002022 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 470137002023 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 470137002024 putative ligand binding residues [chemical binding]; other site 470137002025 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 470137002026 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 470137002027 HlyD family secretion protein; Region: HlyD_3; pfam13437 470137002028 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 470137002029 Fusaric acid resistance protein family; Region: FUSC; pfam04632 470137002030 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 470137002031 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 470137002032 MarR family; Region: MarR_2; pfam12802 470137002033 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 470137002034 RNA methyltransferase, RsmE family; Region: TIGR00046 470137002035 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 470137002036 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 470137002037 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 470137002038 generic binding surface II; other site 470137002039 generic binding surface I; other site 470137002040 Transcriptional regulator [Transcription]; Region: LysR; COG0583 470137002041 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 470137002042 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 470137002043 dimerization interface [polypeptide binding]; other site 470137002044 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 470137002045 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 470137002046 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 470137002047 hypothetical protein; Reviewed; Region: PRK12275 470137002048 four helix bundle protein; Region: TIGR02436 470137002049 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 470137002050 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 470137002051 Transcriptional regulators [Transcription]; Region: MarR; COG1846 470137002052 Hint domain; Region: Hint_2; pfam13403 470137002053 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 470137002054 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 470137002055 putative DNA binding site [nucleotide binding]; other site 470137002056 putative Zn2+ binding site [ion binding]; other site 470137002057 AsnC family; Region: AsnC_trans_reg; pfam01037 470137002058 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 470137002059 Predicted membrane protein [Function unknown]; Region: COG4541 470137002060 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345 470137002061 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 470137002062 putative NAD(P) binding site [chemical binding]; other site 470137002063 active site 470137002064 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 470137002065 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 470137002066 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 470137002067 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 470137002068 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 470137002069 putative active site [active] 470137002070 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 470137002071 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 470137002072 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 470137002073 homodimer interface [polypeptide binding]; other site 470137002074 NADP binding site [chemical binding]; other site 470137002075 substrate binding site [chemical binding]; other site 470137002076 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 470137002077 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 470137002078 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 470137002079 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137002080 dimer interface [polypeptide binding]; other site 470137002081 conserved gate region; other site 470137002082 putative PBP binding loops; other site 470137002083 ABC-ATPase subunit interface; other site 470137002084 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 470137002085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137002086 dimer interface [polypeptide binding]; other site 470137002087 conserved gate region; other site 470137002088 putative PBP binding loops; other site 470137002089 ABC-ATPase subunit interface; other site 470137002090 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 470137002091 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 470137002092 Eukaryotic translation initiation factor 3 subunit 8 N-terminus; Region: eIF-3c_N; pfam05470 470137002093 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 470137002094 active site clefts [active] 470137002095 zinc binding site [ion binding]; other site 470137002096 dimer interface [polypeptide binding]; other site 470137002097 tellurite resistance protein terB; Region: terB; cd07176 470137002098 putative metal binding site [ion binding]; other site 470137002099 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 470137002100 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 470137002101 active site 470137002102 nucleotide binding site [chemical binding]; other site 470137002103 HIGH motif; other site 470137002104 KMSKS motif; other site 470137002105 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 470137002106 Predicted transcriptional regulator [Transcription]; Region: COG2932 470137002107 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 470137002108 Catalytic site [active] 470137002109 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 470137002110 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 470137002111 substrate binding site [chemical binding]; other site 470137002112 oxyanion hole (OAH) forming residues; other site 470137002113 trimer interface [polypeptide binding]; other site 470137002114 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 470137002115 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 470137002116 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 470137002117 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 470137002118 dimer interface [polypeptide binding]; other site 470137002119 active site 470137002120 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 470137002121 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 470137002122 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 470137002123 FAD binding site [chemical binding]; other site 470137002124 substrate binding site [chemical binding]; other site 470137002125 catalytic residues [active] 470137002126 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 470137002127 Transcriptional regulator [Transcription]; Region: LysR; COG0583 470137002128 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 470137002129 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 470137002130 putative dimerization interface [polypeptide binding]; other site 470137002131 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 470137002132 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 470137002133 Walker A/P-loop; other site 470137002134 ATP binding site [chemical binding]; other site 470137002135 Q-loop/lid; other site 470137002136 ABC transporter signature motif; other site 470137002137 Walker B; other site 470137002138 D-loop; other site 470137002139 H-loop/switch region; other site 470137002140 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 470137002141 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 470137002142 Walker A/P-loop; other site 470137002143 ATP binding site [chemical binding]; other site 470137002144 Q-loop/lid; other site 470137002145 ABC transporter signature motif; other site 470137002146 Walker B; other site 470137002147 D-loop; other site 470137002148 H-loop/switch region; other site 470137002149 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 470137002150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137002151 dimer interface [polypeptide binding]; other site 470137002152 conserved gate region; other site 470137002153 putative PBP binding loops; other site 470137002154 ABC-ATPase subunit interface; other site 470137002155 nickel transporter permease NikB; Provisional; Region: PRK10352 470137002156 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137002157 dimer interface [polypeptide binding]; other site 470137002158 conserved gate region; other site 470137002159 putative PBP binding loops; other site 470137002160 ABC-ATPase subunit interface; other site 470137002161 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 470137002162 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 470137002163 substrate binding site [chemical binding]; other site 470137002164 nickel responsive regulator; Provisional; Region: PRK02967 470137002165 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 470137002166 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 470137002167 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 470137002168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137002169 dimer interface [polypeptide binding]; other site 470137002170 conserved gate region; other site 470137002171 putative PBP binding loops; other site 470137002172 ABC-ATPase subunit interface; other site 470137002173 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 470137002174 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 470137002175 Walker A/P-loop; other site 470137002176 ATP binding site [chemical binding]; other site 470137002177 Q-loop/lid; other site 470137002178 ABC transporter signature motif; other site 470137002179 Walker B; other site 470137002180 D-loop; other site 470137002181 H-loop/switch region; other site 470137002182 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 470137002183 hypothetical protein; Provisional; Region: PRK11622 470137002184 glucuronate isomerase; Reviewed; Region: PRK02925 470137002185 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 470137002186 Transcriptional regulators [Transcription]; Region: GntR; COG1802 470137002187 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 470137002188 DNA-binding site [nucleotide binding]; DNA binding site 470137002189 FCD domain; Region: FCD; pfam07729 470137002190 mannonate dehydratase; Region: uxuA; TIGR00695 470137002191 mannonate dehydratase; Provisional; Region: PRK03906 470137002192 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 470137002193 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 470137002194 HlyD family secretion protein; Region: HlyD_3; pfam13437 470137002195 camphor resistance protein CrcB; Provisional; Region: PRK14233 470137002196 camphor resistance protein CrcB; Provisional; Region: PRK14225 470137002197 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 470137002198 Protein of unknown function (DUF3422); Region: DUF3422; cl02073 470137002199 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 470137002200 Sel1-like repeats; Region: SEL1; smart00671 470137002201 Sel1-like repeats; Region: SEL1; smart00671 470137002202 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 470137002203 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 470137002204 conserved hypothetical protein; Region: alph_Pro_TM; TIGR02186 470137002205 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 470137002206 putative active site [active] 470137002207 putative metal binding site [ion binding]; other site 470137002208 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 470137002209 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 470137002210 ATP binding site [chemical binding]; other site 470137002211 putative Mg++ binding site [ion binding]; other site 470137002212 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 470137002213 nucleotide binding region [chemical binding]; other site 470137002214 ATP-binding site [chemical binding]; other site 470137002215 DEAD/H associated; Region: DEAD_assoc; pfam08494 470137002216 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 470137002217 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 470137002218 FMN binding site [chemical binding]; other site 470137002219 substrate binding site [chemical binding]; other site 470137002220 putative catalytic residue [active] 470137002221 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 470137002222 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 470137002223 HsdM N-terminal domain; Region: HsdM_N; pfam12161 470137002224 Methyltransferase domain; Region: Methyltransf_26; pfam13659 470137002225 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 470137002226 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 470137002227 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 470137002228 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 470137002229 ATP binding site [chemical binding]; other site 470137002230 putative Mg++ binding site [ion binding]; other site 470137002231 helicase superfamily c-terminal domain; Region: HELICc; smart00490 470137002232 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 470137002233 Protein of unknown function DUF45; Region: DUF45; pfam01863 470137002234 Protein of unknown function DUF91; Region: DUF91; cl00709 470137002235 Uncharacterized conserved protein [Function unknown]; Region: COG3586 470137002236 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 470137002237 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 470137002238 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 470137002239 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 470137002240 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 470137002241 inhibitor-cofactor binding pocket; inhibition site 470137002242 pyridoxal 5'-phosphate binding site [chemical binding]; other site 470137002243 catalytic residue [active] 470137002244 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 470137002245 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 470137002246 NAD(P) binding site [chemical binding]; other site 470137002247 active site 470137002248 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 470137002249 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 470137002250 FAD binding domain; Region: FAD_binding_4; pfam01565 470137002251 hypothetical protein; Validated; Region: PRK08238 470137002252 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 470137002253 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 470137002254 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 470137002255 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 470137002256 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 470137002257 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 470137002258 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 470137002259 ligand binding site [chemical binding]; other site 470137002260 dimerization interface [polypeptide binding]; other site 470137002261 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 470137002262 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 470137002263 TM-ABC transporter signature motif; other site 470137002264 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 470137002265 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 470137002266 Walker A/P-loop; other site 470137002267 ATP binding site [chemical binding]; other site 470137002268 Q-loop/lid; other site 470137002269 ABC transporter signature motif; other site 470137002270 Walker B; other site 470137002271 D-loop; other site 470137002272 H-loop/switch region; other site 470137002273 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 470137002274 Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; pfam10054 470137002275 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 470137002276 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 470137002277 putative N- and C-terminal domain interface [polypeptide binding]; other site 470137002278 putative active site [active] 470137002279 MgATP binding site [chemical binding]; other site 470137002280 catalytic site [active] 470137002281 metal binding site [ion binding]; metal-binding site 470137002282 putative xylulose binding site [chemical binding]; other site 470137002283 glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369 470137002284 hydroxyglutarate oxidase; Provisional; Region: PRK11728 470137002285 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 470137002286 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 470137002287 PCI domain; Region: PCI; cl02111 470137002288 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 470137002289 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 470137002290 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 470137002291 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 470137002292 triosephosphate isomerase; Provisional; Region: PRK14565 470137002293 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 470137002294 substrate binding site [chemical binding]; other site 470137002295 dimer interface [polypeptide binding]; other site 470137002296 catalytic triad [active] 470137002297 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 470137002298 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 470137002299 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 470137002300 intersubunit interface [polypeptide binding]; other site 470137002301 active site 470137002302 zinc binding site [ion binding]; other site 470137002303 Na+ binding site [ion binding]; other site 470137002304 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 470137002305 AMP binding site [chemical binding]; other site 470137002306 metal binding site [ion binding]; metal-binding site 470137002307 active site 470137002308 Uncharacterized conserved protein [Function unknown]; Region: COG1739 470137002309 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 470137002310 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 470137002311 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 470137002312 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 470137002313 G1 box; other site 470137002314 putative GEF interaction site [polypeptide binding]; other site 470137002315 GTP/Mg2+ binding site [chemical binding]; other site 470137002316 Switch I region; other site 470137002317 G2 box; other site 470137002318 G3 box; other site 470137002319 Switch II region; other site 470137002320 G4 box; other site 470137002321 G5 box; other site 470137002322 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 470137002323 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 470137002324 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 470137002325 MgtE intracellular N domain; Region: MgtE_N; pfam03448 470137002326 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 470137002327 Divalent cation transporter; Region: MgtE; pfam01769 470137002328 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 470137002329 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 470137002330 active site 470137002331 Zn binding site [ion binding]; other site 470137002332 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 470137002333 dimer interface [polypeptide binding]; other site 470137002334 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 470137002335 Uncharacterized conserved small protein [Function unknown]; Region: COG5515 470137002336 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 470137002337 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 470137002338 substrate binding site [chemical binding]; other site 470137002339 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 470137002340 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 470137002341 Transcriptional regulators [Transcription]; Region: MarR; COG1846 470137002342 MarR family; Region: MarR; pfam01047 470137002343 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 470137002344 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 470137002345 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 470137002346 putative substrate translocation pore; other site 470137002347 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 470137002348 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 470137002349 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 470137002350 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 470137002351 DNA binding site [nucleotide binding] 470137002352 active site 470137002353 tartrate dehydrogenase; Region: TTC; TIGR02089 470137002354 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 470137002355 Uncharacterized conserved protein [Function unknown]; Region: COG2835 470137002356 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 470137002357 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 470137002358 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 470137002359 catalytic residues [active] 470137002360 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 470137002361 putative deacylase active site [active] 470137002362 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 470137002363 apolar tunnel; other site 470137002364 heme binding site [chemical binding]; other site 470137002365 dimerization interface [polypeptide binding]; other site 470137002366 ornithine cyclodeaminase; Validated; Region: PRK07589 470137002367 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 470137002368 Arginase family; Region: Arginase; cd09989 470137002369 agmatinase; Region: agmatinase; TIGR01230 470137002370 active site 470137002371 Mn binding site [ion binding]; other site 470137002372 oligomer interface [polypeptide binding]; other site 470137002373 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 470137002374 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 470137002375 AsnC family; Region: AsnC_trans_reg; pfam01037 470137002376 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 470137002377 dimerization interface [polypeptide binding]; other site 470137002378 putative DNA binding site [nucleotide binding]; other site 470137002379 putative Zn2+ binding site [ion binding]; other site 470137002380 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 470137002381 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 470137002382 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 470137002383 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 470137002384 RNA binding site [nucleotide binding]; other site 470137002385 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 470137002386 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 470137002387 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 470137002388 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 470137002389 putative Zn2+ binding site [ion binding]; other site 470137002390 putative DNA binding site [nucleotide binding]; other site 470137002391 dimerization interface [polypeptide binding]; other site 470137002392 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 470137002393 dimerization interface [polypeptide binding]; other site 470137002394 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 470137002395 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 470137002396 aldehyde dehydrogenase family 7 member; Region: PLN02315 470137002397 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 470137002398 tetrameric interface [polypeptide binding]; other site 470137002399 NAD binding site [chemical binding]; other site 470137002400 catalytic residues [active] 470137002401 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 470137002402 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 470137002403 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 470137002404 putative active site [active] 470137002405 putative substrate binding site [chemical binding]; other site 470137002406 putative cosubstrate binding site; other site 470137002407 catalytic site [active] 470137002408 hypothetical protein; Provisional; Region: PRK02947 470137002409 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 470137002410 putative active site [active] 470137002411 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 470137002412 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 470137002413 active site 470137002414 dimer interface [polypeptide binding]; other site 470137002415 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 470137002416 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 470137002417 dimer interface [polypeptide binding]; other site 470137002418 active site 470137002419 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 470137002420 dimer interface [polypeptide binding]; other site 470137002421 active site 470137002422 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 470137002423 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 470137002424 DNA-binding site [nucleotide binding]; DNA binding site 470137002425 UTRA domain; Region: UTRA; pfam07702 470137002426 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 470137002427 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 470137002428 HlyD family secretion protein; Region: HlyD_3; pfam13437 470137002429 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 470137002430 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 470137002431 HlyD family secretion protein; Region: HlyD_3; pfam13437 470137002432 putative membrane fusion protein; Region: TIGR02828 470137002433 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 470137002434 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 470137002435 phosphate binding site [ion binding]; other site 470137002436 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 470137002437 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 470137002438 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 470137002439 putative DNA binding site [nucleotide binding]; other site 470137002440 putative Zn2+ binding site [ion binding]; other site 470137002441 AsnC family; Region: AsnC_trans_reg; pfam01037 470137002442 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 470137002443 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 470137002444 active site 470137002445 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 470137002446 dimer interface [polypeptide binding]; other site 470137002447 substrate binding site [chemical binding]; other site 470137002448 catalytic residues [active] 470137002449 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 470137002450 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 470137002451 hydroxyglutarate oxidase; Provisional; Region: PRK11728 470137002452 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 470137002453 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 470137002454 non-specific DNA binding site [nucleotide binding]; other site 470137002455 salt bridge; other site 470137002456 sequence-specific DNA binding site [nucleotide binding]; other site 470137002457 Cupin domain; Region: Cupin_2; pfam07883 470137002458 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 470137002459 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 470137002460 inhibitor-cofactor binding pocket; inhibition site 470137002461 pyridoxal 5'-phosphate binding site [chemical binding]; other site 470137002462 catalytic residue [active] 470137002463 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 470137002464 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 470137002465 DNA-binding site [nucleotide binding]; DNA binding site 470137002466 UTRA domain; Region: UTRA; pfam07702 470137002467 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 470137002468 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 470137002469 active site 470137002470 imidazolonepropionase; Validated; Region: PRK09356 470137002471 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 470137002472 active site 470137002473 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 470137002474 active sites [active] 470137002475 tetramer interface [polypeptide binding]; other site 470137002476 N-formylglutamate amidohydrolase; Region: hutG_amidohyd; TIGR02017 470137002477 urocanate hydratase; Provisional; Region: PRK05414 470137002478 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3758 470137002479 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 470137002480 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 470137002481 homodimer interface [polypeptide binding]; other site 470137002482 substrate-cofactor binding pocket; other site 470137002483 pyridoxal 5'-phosphate binding site [chemical binding]; other site 470137002484 catalytic residue [active] 470137002485 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 470137002486 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 470137002487 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 470137002488 TM-ABC transporter signature motif; other site 470137002489 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 470137002490 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 470137002491 Walker A/P-loop; other site 470137002492 ATP binding site [chemical binding]; other site 470137002493 Q-loop/lid; other site 470137002494 ABC transporter signature motif; other site 470137002495 Walker B; other site 470137002496 D-loop; other site 470137002497 H-loop/switch region; other site 470137002498 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 470137002499 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 470137002500 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 470137002501 putative ligand binding site [chemical binding]; other site 470137002502 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 470137002503 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 470137002504 active site 470137002505 intersubunit interface [polypeptide binding]; other site 470137002506 catalytic residue [active] 470137002507 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 470137002508 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 470137002509 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 470137002510 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 470137002511 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 470137002512 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 470137002513 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 470137002514 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 470137002515 D-aminopeptidase; Reviewed; Region: PRK13128 470137002516 Beta-lactamase; Region: Beta-lactamase; pfam00144 470137002517 D-aminopeptidase, domain B; Region: DAP_B; pfam07930 470137002518 D-aminopeptidase, domain C; Region: DAP_C; pfam07932 470137002519 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 470137002520 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 470137002521 substrate binding pocket [chemical binding]; other site 470137002522 membrane-bound complex binding site; other site 470137002523 hinge residues; other site 470137002524 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 470137002525 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 470137002526 AsnC family; Region: AsnC_trans_reg; pfam01037 470137002527 Transcriptional regulator [Transcription]; Region: LysR; COG0583 470137002528 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 470137002529 LysR substrate binding domain; Region: LysR_substrate; pfam03466 470137002530 dimerization interface [polypeptide binding]; other site 470137002531 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 470137002532 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 470137002533 putative ligand binding site [chemical binding]; other site 470137002534 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 470137002535 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 470137002536 Walker A/P-loop; other site 470137002537 ATP binding site [chemical binding]; other site 470137002538 Q-loop/lid; other site 470137002539 ABC transporter signature motif; other site 470137002540 Walker B; other site 470137002541 D-loop; other site 470137002542 H-loop/switch region; other site 470137002543 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 470137002544 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 470137002545 Walker A/P-loop; other site 470137002546 ATP binding site [chemical binding]; other site 470137002547 Q-loop/lid; other site 470137002548 ABC transporter signature motif; other site 470137002549 Walker B; other site 470137002550 D-loop; other site 470137002551 H-loop/switch region; other site 470137002552 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 470137002553 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 470137002554 TM-ABC transporter signature motif; other site 470137002555 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 470137002556 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 470137002557 TM-ABC transporter signature motif; other site 470137002558 choline dehydrogenase; Validated; Region: PRK02106 470137002559 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 470137002560 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 470137002561 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 470137002562 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 470137002563 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 470137002564 Walker A/P-loop; other site 470137002565 ATP binding site [chemical binding]; other site 470137002566 Q-loop/lid; other site 470137002567 ABC transporter signature motif; other site 470137002568 Walker B; other site 470137002569 D-loop; other site 470137002570 H-loop/switch region; other site 470137002571 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 470137002572 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137002573 dimer interface [polypeptide binding]; other site 470137002574 conserved gate region; other site 470137002575 ABC-ATPase subunit interface; other site 470137002576 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 470137002577 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 470137002578 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 470137002579 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 470137002580 TPR motif; other site 470137002581 binding surface 470137002582 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 470137002583 binding surface 470137002584 TPR motif; other site 470137002585 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 470137002586 binding surface 470137002587 TPR motif; other site 470137002588 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 470137002589 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 470137002590 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 470137002591 putative active site [active] 470137002592 putative catalytic site [active] 470137002593 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 470137002594 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 470137002595 motif II; other site 470137002596 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 470137002597 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 470137002598 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 470137002599 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 470137002600 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 470137002601 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 470137002602 Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835 470137002603 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 470137002604 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 470137002605 Beta-lactamase; Region: Beta-lactamase; pfam00144 470137002606 PAS fold; Region: PAS_7; pfam12860 470137002607 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 470137002608 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 470137002609 metal binding site [ion binding]; metal-binding site 470137002610 active site 470137002611 I-site; other site 470137002612 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 470137002613 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 470137002614 classical (c) SDRs; Region: SDR_c; cd05233 470137002615 NAD(P) binding site [chemical binding]; other site 470137002616 active site 470137002617 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 470137002618 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 470137002619 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 470137002620 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 470137002621 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 470137002622 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 470137002623 catalytic triad [active] 470137002624 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 470137002625 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 470137002626 putative ligand binding site [chemical binding]; other site 470137002627 NAD binding site [chemical binding]; other site 470137002628 catalytic site [active] 470137002629 Transcriptional regulators [Transcription]; Region: PurR; COG1609 470137002630 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 470137002631 DNA binding site [nucleotide binding] 470137002632 domain linker motif; other site 470137002633 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 470137002634 putative dimerization interface [polypeptide binding]; other site 470137002635 putative ligand binding site [chemical binding]; other site 470137002636 transcriptional regulator SlyA; Provisional; Region: PRK03573 470137002637 Creatinine amidohydrolase; Region: Creatininase; pfam02633 470137002638 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 470137002639 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 470137002640 P-loop, Walker A motif; other site 470137002641 Base recognition motif; other site 470137002642 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 470137002643 FOG: WD40 repeat [General function prediction only]; Region: COG2319 470137002644 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 470137002645 structural tetrad; other site 470137002646 Predicted esterase [General function prediction only]; Region: COG0400 470137002647 putative hydrolase; Provisional; Region: PRK11460 470137002648 TMAO/DMSO reductase; Reviewed; Region: PRK05363 470137002649 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 470137002650 Moco binding site; other site 470137002651 metal coordination site [ion binding]; other site 470137002652 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 470137002653 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 470137002654 homotrimer interaction site [polypeptide binding]; other site 470137002655 putative active site [active] 470137002656 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 470137002657 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 470137002658 TM-ABC transporter signature motif; other site 470137002659 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 470137002660 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 470137002661 TM-ABC transporter signature motif; other site 470137002662 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 470137002663 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 470137002664 Walker A/P-loop; other site 470137002665 ATP binding site [chemical binding]; other site 470137002666 Q-loop/lid; other site 470137002667 ABC transporter signature motif; other site 470137002668 Walker B; other site 470137002669 D-loop; other site 470137002670 H-loop/switch region; other site 470137002671 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 470137002672 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 470137002673 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 470137002674 putative ligand binding site [chemical binding]; other site 470137002675 Transcriptional regulator [Transcription]; Region: IclR; COG1414 470137002676 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 470137002677 Bacterial transcriptional regulator; Region: IclR; pfam01614 470137002678 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 470137002679 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 470137002680 N-terminal plug; other site 470137002681 ligand-binding site [chemical binding]; other site 470137002682 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 470137002683 dimer interface [polypeptide binding]; other site 470137002684 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 470137002685 metal binding site [ion binding]; metal-binding site 470137002686 glutathionine S-transferase; Provisional; Region: PRK10542 470137002687 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 470137002688 C-terminal domain interface [polypeptide binding]; other site 470137002689 GSH binding site (G-site) [chemical binding]; other site 470137002690 dimer interface [polypeptide binding]; other site 470137002691 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 470137002692 dimer interface [polypeptide binding]; other site 470137002693 N-terminal domain interface [polypeptide binding]; other site 470137002694 substrate binding pocket (H-site) [chemical binding]; other site 470137002695 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 470137002696 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 470137002697 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 470137002698 metal binding site [ion binding]; metal-binding site 470137002699 active site 470137002700 I-site; other site 470137002701 Predicted dehydrogenase [General function prediction only]; Region: COG0579 470137002702 hydroxyglutarate oxidase; Provisional; Region: PRK11728 470137002703 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 470137002704 DNA polymerase III subunit epsilon; Validated; Region: PRK09182 470137002705 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 470137002706 active site 470137002707 catalytic site [active] 470137002708 substrate binding site [chemical binding]; other site 470137002709 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 470137002710 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 470137002711 Walker A/P-loop; other site 470137002712 ATP binding site [chemical binding]; other site 470137002713 Q-loop/lid; other site 470137002714 ABC transporter signature motif; other site 470137002715 Walker B; other site 470137002716 D-loop; other site 470137002717 H-loop/switch region; other site 470137002718 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 470137002719 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 470137002720 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 470137002721 Walker A/P-loop; other site 470137002722 ATP binding site [chemical binding]; other site 470137002723 Q-loop/lid; other site 470137002724 ABC transporter signature motif; other site 470137002725 Walker B; other site 470137002726 D-loop; other site 470137002727 H-loop/switch region; other site 470137002728 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 470137002729 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 470137002730 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137002731 dimer interface [polypeptide binding]; other site 470137002732 conserved gate region; other site 470137002733 putative PBP binding loops; other site 470137002734 ABC-ATPase subunit interface; other site 470137002735 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 470137002736 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137002737 dimer interface [polypeptide binding]; other site 470137002738 conserved gate region; other site 470137002739 putative PBP binding loops; other site 470137002740 ABC-ATPase subunit interface; other site 470137002741 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 470137002742 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 470137002743 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345 470137002744 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 470137002745 putative NAD(P) binding site [chemical binding]; other site 470137002746 active site 470137002747 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 470137002748 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 470137002749 NAD(P) binding site [chemical binding]; other site 470137002750 catalytic residues [active] 470137002751 catalytic residues [active] 470137002752 Transcriptional regulators [Transcription]; Region: GntR; COG1802 470137002753 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 470137002754 DNA-binding site [nucleotide binding]; DNA binding site 470137002755 FCD domain; Region: FCD; pfam07729 470137002756 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 470137002757 Major Facilitator Superfamily; Region: MFS_1; pfam07690 470137002758 putative substrate translocation pore; other site 470137002759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 470137002760 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 470137002761 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 470137002762 homotrimer interaction site [polypeptide binding]; other site 470137002763 putative active site [active] 470137002764 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 470137002765 ribonuclease P; Reviewed; Region: rnpA; PRK01313 470137002766 membrane protein insertase; Provisional; Region: PRK01318 470137002767 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 470137002768 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 470137002769 G1 box; other site 470137002770 GTP/Mg2+ binding site [chemical binding]; other site 470137002771 Switch I region; other site 470137002772 G2 box; other site 470137002773 G3 box; other site 470137002774 Switch II region; other site 470137002775 G4 box; other site 470137002776 G5 box; other site 470137002777 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 470137002778 homohexameric interface [polypeptide binding]; other site 470137002779 feedback inhibition sensing region; other site 470137002780 nucleotide binding site [chemical binding]; other site 470137002781 N-acetyl-L-glutamate binding site [chemical binding]; other site 470137002782 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 470137002783 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 470137002784 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 470137002785 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 470137002786 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 470137002787 trimer interface [polypeptide binding]; other site 470137002788 active site 470137002789 substrate binding site [chemical binding]; other site 470137002790 CoA binding site [chemical binding]; other site 470137002791 Predicted transglutaminase-like cysteine proteinase [General function prediction only]; Region: COG3672 470137002792 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 470137002793 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 470137002794 metal binding site [ion binding]; metal-binding site 470137002795 dimer interface [polypeptide binding]; other site 470137002796 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 470137002797 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 470137002798 dimerization interface 3.5A [polypeptide binding]; other site 470137002799 active site 470137002800 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 470137002801 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 470137002802 putative active site [active] 470137002803 substrate binding site [chemical binding]; other site 470137002804 putative cosubstrate binding site; other site 470137002805 catalytic site [active] 470137002806 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 470137002807 substrate binding site [chemical binding]; other site 470137002808 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 470137002809 active site 470137002810 catalytic residues [active] 470137002811 metal binding site [ion binding]; metal-binding site 470137002812 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 470137002813 RmuC family; Region: RmuC; pfam02646 470137002814 Uncharacterized protein conserved in bacteria [Posttranslational modification, protein turnover, chaperones]; Region: COG3526 470137002815 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 470137002816 GIY-YIG motif/motif A; other site 470137002817 putative active site [active] 470137002818 putative metal binding site [ion binding]; other site 470137002819 GTP-binding protein LepA; Provisional; Region: PRK05433 470137002820 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 470137002821 G1 box; other site 470137002822 putative GEF interaction site [polypeptide binding]; other site 470137002823 GTP/Mg2+ binding site [chemical binding]; other site 470137002824 Switch I region; other site 470137002825 G2 box; other site 470137002826 G3 box; other site 470137002827 Switch II region; other site 470137002828 G4 box; other site 470137002829 G5 box; other site 470137002830 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 470137002831 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 470137002832 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 470137002833 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 470137002834 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 470137002835 putative NAD(P) binding site [chemical binding]; other site 470137002836 active site 470137002837 Undecaprenyl pyrophosphate phosphatase [Lipid transport and metabolism]; Region: BacA; COG1968 470137002838 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 470137002839 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 470137002840 C-terminal domain interface [polypeptide binding]; other site 470137002841 GSH binding site (G-site) [chemical binding]; other site 470137002842 dimer interface [polypeptide binding]; other site 470137002843 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 470137002844 N-terminal domain interface [polypeptide binding]; other site 470137002845 dimer interface [polypeptide binding]; other site 470137002846 substrate binding pocket (H-site) [chemical binding]; other site 470137002847 epoxyqueuosine reductase; Region: TIGR00276 470137002848 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 470137002849 HEAT repeat; Region: HEAT; pfam02985 470137002850 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 470137002851 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 470137002852 putative NAD(P) binding site [chemical binding]; other site 470137002853 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 470137002854 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 470137002855 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 470137002856 active site 470137002857 dimer interfaces [polypeptide binding]; other site 470137002858 catalytic residues [active] 470137002859 Glucokinase [Carbohydrate transport and metabolism]; Region: Glk; COG0837 470137002860 glucokinase, proteobacterial type; Region: glk; TIGR00749 470137002861 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 470137002862 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 470137002863 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 470137002864 Walker A/P-loop; other site 470137002865 ATP binding site [chemical binding]; other site 470137002866 Q-loop/lid; other site 470137002867 ABC transporter signature motif; other site 470137002868 Walker B; other site 470137002869 D-loop; other site 470137002870 H-loop/switch region; other site 470137002871 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 470137002872 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 470137002873 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 470137002874 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 470137002875 catalytic core [active] 470137002876 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 470137002877 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 470137002878 active site 470137002879 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 470137002880 putative FMN binding site [chemical binding]; other site 470137002881 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 470137002882 Ligand Binding Site [chemical binding]; other site 470137002883 Predicted membrane protein [Function unknown]; Region: COG3714 470137002884 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 470137002885 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 470137002886 NAD(P) binding site [chemical binding]; other site 470137002887 catalytic residues [active] 470137002888 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 470137002889 putative catalytic site [active] 470137002890 putative metal binding site [ion binding]; other site 470137002891 putative phosphate binding site [ion binding]; other site 470137002892 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 470137002893 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 470137002894 putative active site [active] 470137002895 catalytic site [active] 470137002896 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 470137002897 putative active site [active] 470137002898 catalytic site [active] 470137002899 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 470137002900 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 470137002901 G1 box; other site 470137002902 putative GEF interaction site [polypeptide binding]; other site 470137002903 GTP/Mg2+ binding site [chemical binding]; other site 470137002904 Switch I region; other site 470137002905 G2 box; other site 470137002906 G3 box; other site 470137002907 Switch II region; other site 470137002908 G4 box; other site 470137002909 G5 box; other site 470137002910 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 470137002911 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 470137002912 Flavoprotein; Region: Flavoprotein; pfam02441 470137002913 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 470137002914 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 470137002915 ABC1 family; Region: ABC1; pfam03109 470137002916 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 470137002917 active site 470137002918 ATP binding site [chemical binding]; other site 470137002919 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 470137002920 substrate binding site [chemical binding]; other site 470137002921 activation loop (A-loop); other site 470137002922 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 470137002923 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 470137002924 S-adenosylmethionine binding site [chemical binding]; other site 470137002925 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 470137002926 active site 470137002927 hypothetical protein; Provisional; Region: PRK00736 470137002928 methionine sulfoxide reductase A; Provisional; Region: PRK00058 470137002929 putative transposase OrfB; Reviewed; Region: PHA02517 470137002930 HTH-like domain; Region: HTH_21; pfam13276 470137002931 Integrase core domain; Region: rve; pfam00665 470137002932 Integrase core domain; Region: rve_3; pfam13683 470137002933 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 470137002934 Transposase; Region: HTH_Tnp_1; pfam01527 470137002935 Transcriptional regulators [Transcription]; Region: GntR; COG1802 470137002936 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 470137002937 DNA-binding site [nucleotide binding]; DNA binding site 470137002938 FCD domain; Region: FCD; pfam07729 470137002939 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 470137002940 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 470137002941 tetramerization interface [polypeptide binding]; other site 470137002942 NAD(P) binding site [chemical binding]; other site 470137002943 catalytic residues [active] 470137002944 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 470137002945 CoA-transferase family III; Region: CoA_transf_3; pfam02515 470137002946 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 470137002947 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 470137002948 Walker A/P-loop; other site 470137002949 ATP binding site [chemical binding]; other site 470137002950 Q-loop/lid; other site 470137002951 ABC transporter signature motif; other site 470137002952 Walker B; other site 470137002953 D-loop; other site 470137002954 H-loop/switch region; other site 470137002955 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 470137002956 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 470137002957 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 470137002958 Walker A/P-loop; other site 470137002959 ATP binding site [chemical binding]; other site 470137002960 Q-loop/lid; other site 470137002961 ABC transporter signature motif; other site 470137002962 Walker B; other site 470137002963 D-loop; other site 470137002964 H-loop/switch region; other site 470137002965 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 470137002966 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 470137002967 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137002968 dimer interface [polypeptide binding]; other site 470137002969 conserved gate region; other site 470137002970 putative PBP binding loops; other site 470137002971 ABC-ATPase subunit interface; other site 470137002972 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 470137002973 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137002974 dimer interface [polypeptide binding]; other site 470137002975 conserved gate region; other site 470137002976 putative PBP binding loops; other site 470137002977 ABC-ATPase subunit interface; other site 470137002978 Transcriptional regulator [Transcription]; Region: IclR; COG1414 470137002979 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 470137002980 Bacterial transcriptional regulator; Region: IclR; pfam01614 470137002981 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 470137002982 Serine hydrolase; Region: Ser_hydrolase; cl17834 470137002983 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 470137002984 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 470137002985 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 470137002986 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 470137002987 tetramer interface [polypeptide binding]; other site 470137002988 TPP-binding site [chemical binding]; other site 470137002989 heterodimer interface [polypeptide binding]; other site 470137002990 phosphorylation loop region [posttranslational modification] 470137002991 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 470137002992 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 470137002993 alpha subunit interface [polypeptide binding]; other site 470137002994 TPP binding site [chemical binding]; other site 470137002995 heterodimer interface [polypeptide binding]; other site 470137002996 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 470137002997 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 470137002998 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 470137002999 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 470137003000 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 470137003001 enoyl-CoA hydratase; Provisional; Region: PRK08138 470137003002 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 470137003003 substrate binding site [chemical binding]; other site 470137003004 oxyanion hole (OAH) forming residues; other site 470137003005 trimer interface [polypeptide binding]; other site 470137003006 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 470137003007 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 470137003008 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 470137003009 active site 470137003010 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 470137003011 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 470137003012 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 470137003013 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 470137003014 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137003015 dimer interface [polypeptide binding]; other site 470137003016 conserved gate region; other site 470137003017 putative PBP binding loops; other site 470137003018 ABC-ATPase subunit interface; other site 470137003019 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 470137003020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137003021 dimer interface [polypeptide binding]; other site 470137003022 conserved gate region; other site 470137003023 putative PBP binding loops; other site 470137003024 ABC-ATPase subunit interface; other site 470137003025 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 470137003026 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 470137003027 Walker A/P-loop; other site 470137003028 ATP binding site [chemical binding]; other site 470137003029 Q-loop/lid; other site 470137003030 ABC transporter signature motif; other site 470137003031 Walker B; other site 470137003032 D-loop; other site 470137003033 H-loop/switch region; other site 470137003034 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 470137003035 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 470137003036 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 470137003037 Walker A/P-loop; other site 470137003038 ATP binding site [chemical binding]; other site 470137003039 Q-loop/lid; other site 470137003040 ABC transporter signature motif; other site 470137003041 Walker B; other site 470137003042 D-loop; other site 470137003043 H-loop/switch region; other site 470137003044 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 470137003045 Transcriptional regulators [Transcription]; Region: GntR; COG1802 470137003046 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 470137003047 DNA-binding site [nucleotide binding]; DNA binding site 470137003048 FCD domain; Region: FCD; pfam07729 470137003049 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 470137003050 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 470137003051 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 470137003052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137003053 dimer interface [polypeptide binding]; other site 470137003054 conserved gate region; other site 470137003055 putative PBP binding loops; other site 470137003056 ABC-ATPase subunit interface; other site 470137003057 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 470137003058 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137003059 dimer interface [polypeptide binding]; other site 470137003060 conserved gate region; other site 470137003061 putative PBP binding loops; other site 470137003062 ABC-ATPase subunit interface; other site 470137003063 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 470137003064 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 470137003065 Walker A/P-loop; other site 470137003066 ATP binding site [chemical binding]; other site 470137003067 Q-loop/lid; other site 470137003068 ABC transporter signature motif; other site 470137003069 Walker B; other site 470137003070 D-loop; other site 470137003071 H-loop/switch region; other site 470137003072 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 470137003073 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 470137003074 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 470137003075 Walker A/P-loop; other site 470137003076 ATP binding site [chemical binding]; other site 470137003077 Q-loop/lid; other site 470137003078 ABC transporter signature motif; other site 470137003079 Walker B; other site 470137003080 D-loop; other site 470137003081 H-loop/switch region; other site 470137003082 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 470137003083 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 470137003084 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 470137003085 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 470137003086 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 470137003087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137003088 dimer interface [polypeptide binding]; other site 470137003089 conserved gate region; other site 470137003090 putative PBP binding loops; other site 470137003091 ABC-ATPase subunit interface; other site 470137003092 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137003093 dimer interface [polypeptide binding]; other site 470137003094 conserved gate region; other site 470137003095 putative PBP binding loops; other site 470137003096 ABC-ATPase subunit interface; other site 470137003097 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 470137003098 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 470137003099 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 470137003100 catalytic residue [active] 470137003101 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235 470137003102 intersubunit interface [polypeptide binding]; other site 470137003103 active site 470137003104 Zn2+ binding site [ion binding]; other site 470137003105 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 470137003106 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 470137003107 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 470137003108 putative transposase OrfB; Reviewed; Region: PHA02517 470137003109 HTH-like domain; Region: HTH_21; pfam13276 470137003110 Integrase core domain; Region: rve; pfam00665 470137003111 Integrase core domain; Region: rve_3; pfam13683 470137003112 Transcriptional regulator [Transcription]; Region: IclR; COG1414 470137003113 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 470137003114 Bacterial transcriptional regulator; Region: IclR; pfam01614 470137003115 succinic semialdehyde dehydrogenase; Region: PLN02278 470137003116 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 470137003117 tetramerization interface [polypeptide binding]; other site 470137003118 NAD(P) binding site [chemical binding]; other site 470137003119 catalytic residues [active] 470137003120 Predicted membrane protein [Function unknown]; Region: COG1238 470137003121 Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495 470137003122 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 470137003123 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 470137003124 active site 470137003125 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 470137003126 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 470137003127 helix-hairpin-helix signature motif; other site 470137003128 substrate binding pocket [chemical binding]; other site 470137003129 active site 470137003130 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 470137003131 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 470137003132 active site 470137003133 HIGH motif; other site 470137003134 nucleotide binding site [chemical binding]; other site 470137003135 active site 470137003136 KMSKS motif; other site 470137003137 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 470137003138 active site 470137003139 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 470137003140 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 470137003141 Coenzyme A binding pocket [chemical binding]; other site 470137003142 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 470137003143 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 470137003144 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 470137003145 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 470137003146 DNA binding residues [nucleotide binding] 470137003147 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 470137003148 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 470137003149 RNA binding surface [nucleotide binding]; other site 470137003150 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 470137003151 active site 470137003152 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 470137003153 metal binding site 2 [ion binding]; metal-binding site 470137003154 putative DNA binding helix; other site 470137003155 metal binding site 1 [ion binding]; metal-binding site 470137003156 dimer interface [polypeptide binding]; other site 470137003157 structural Zn2+ binding site [ion binding]; other site 470137003158 PAS fold; Region: PAS_4; pfam08448 470137003159 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 470137003160 HWE histidine kinase; Region: HWE_HK; pfam07536 470137003161 two-component response regulator; Provisional; Region: PRK09191 470137003162 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 470137003163 active site 470137003164 phosphorylation site [posttranslational modification] 470137003165 intermolecular recognition site; other site 470137003166 dimerization interface [polypeptide binding]; other site 470137003167 RNA polymerase sigma factor; Provisional; Region: PRK12516 470137003168 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 470137003169 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 470137003170 DNA binding residues [nucleotide binding] 470137003171 CHASE3 domain; Region: CHASE3; pfam05227 470137003172 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 470137003173 Histidine kinase; Region: HisKA_2; pfam07568 470137003174 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 470137003175 ATP binding site [chemical binding]; other site 470137003176 Mg2+ binding site [ion binding]; other site 470137003177 G-X-G motif; other site 470137003178 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 470137003179 PRC-barrel domain; Region: PRC; pfam05239 470137003180 PRC-barrel domain; Region: PRC; pfam05239 470137003181 tonB-system energizer ExbB; Region: exbB; TIGR02797 470137003182 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 470137003183 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 470137003184 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 470137003185 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 470137003186 Predicted periplasmic protein [Function unknown]; Region: COG3698 470137003187 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 470137003188 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 470137003189 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 470137003190 Walker A/P-loop; other site 470137003191 ATP binding site [chemical binding]; other site 470137003192 Q-loop/lid; other site 470137003193 ABC transporter signature motif; other site 470137003194 Walker B; other site 470137003195 D-loop; other site 470137003196 H-loop/switch region; other site 470137003197 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 470137003198 FtsX-like permease family; Region: FtsX; pfam02687 470137003199 macrolide transporter subunit MacA; Provisional; Region: PRK11578 470137003200 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 470137003201 HlyD family secretion protein; Region: HlyD_3; pfam13437 470137003202 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 470137003203 trimer interface [polypeptide binding]; other site 470137003204 active site 470137003205 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 470137003206 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 470137003207 dimerization interface [polypeptide binding]; other site 470137003208 putative DNA binding site [nucleotide binding]; other site 470137003209 putative Zn2+ binding site [ion binding]; other site 470137003210 AsnC family; Region: AsnC_trans_reg; pfam01037 470137003211 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 470137003212 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 470137003213 putative active site [active] 470137003214 putative dimer interface [polypeptide binding]; other site 470137003215 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 470137003216 diiron binding motif [ion binding]; other site 470137003217 Uncharacterized conserved protein [Function unknown]; Region: COG1633 470137003218 CCC1-related protein family; Region: CCC1_like_1; cd02437 470137003219 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 470137003220 metabolite-proton symporter; Region: 2A0106; TIGR00883 470137003221 putative substrate translocation pore; other site 470137003222 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 470137003223 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 470137003224 GDP-binding site [chemical binding]; other site 470137003225 ACT binding site; other site 470137003226 IMP binding site; other site 470137003227 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 470137003228 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 470137003229 Coenzyme A binding pocket [chemical binding]; other site 470137003230 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 470137003231 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 470137003232 ligand binding site [chemical binding]; other site 470137003233 NAD binding site [chemical binding]; other site 470137003234 dimerization interface [polypeptide binding]; other site 470137003235 catalytic site [active] 470137003236 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 470137003237 putative L-serine binding site [chemical binding]; other site 470137003238 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 470137003239 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 470137003240 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 470137003241 catalytic residue [active] 470137003242 serC leader; BSUIS_B1163 470137003243 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 470137003244 Sodium Bile acid symporter family; Region: SBF; pfam01758 470137003245 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 470137003246 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 470137003247 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 470137003248 active site 470137003249 substrate binding site [chemical binding]; other site 470137003250 metal binding site [ion binding]; metal-binding site 470137003251 FtsH Extracellular; Region: FtsH_ext; pfam06480 470137003252 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 470137003253 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 470137003254 Walker A motif; other site 470137003255 ATP binding site [chemical binding]; other site 470137003256 Walker B motif; other site 470137003257 arginine finger; other site 470137003258 Peptidase family M41; Region: Peptidase_M41; pfam01434 470137003259 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 470137003260 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 470137003261 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 470137003262 Tetratricopeptide repeat; Region: TPR_6; pfam13174 470137003263 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 470137003264 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 470137003265 ligand binding site [chemical binding]; other site 470137003266 translocation protein TolB; Provisional; Region: tolB; PRK05137 470137003267 TolB amino-terminal domain; Region: TolB_N; pfam04052 470137003268 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 470137003269 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 470137003270 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 470137003271 TolR protein; Region: tolR; TIGR02801 470137003272 TolQ protein; Region: tolQ; TIGR02796 470137003273 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 470137003274 active site 470137003275 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 470137003276 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 470137003277 Walker A motif; other site 470137003278 ATP binding site [chemical binding]; other site 470137003279 Walker B motif; other site 470137003280 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 470137003281 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 470137003282 RuvA N terminal domain; Region: RuvA_N; pfam01330 470137003283 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 470137003284 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 470137003285 active site 470137003286 putative DNA-binding cleft [nucleotide binding]; other site 470137003287 dimer interface [polypeptide binding]; other site 470137003288 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5317 470137003289 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4645 470137003290 Acyltransferase family; Region: Acyl_transf_3; pfam01757 470137003291 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 470137003292 active site 470137003293 thiamine phosphate binding site [chemical binding]; other site 470137003294 pyrophosphate binding site [ion binding]; other site 470137003295 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 470137003296 Sel1-like repeats; Region: SEL1; smart00671 470137003297 Sel1-like repeats; Region: SEL1; smart00671 470137003298 elongation factor P; Validated; Region: PRK00529 470137003299 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 470137003300 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 470137003301 RNA binding site [nucleotide binding]; other site 470137003302 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 470137003303 RNA binding site [nucleotide binding]; other site 470137003304 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 470137003305 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 470137003306 active site 470137003307 dimerization interface [polypeptide binding]; other site 470137003308 hypothetical protein; Validated; Region: PRK09039 470137003309 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 470137003310 ligand binding site [chemical binding]; other site 470137003311 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 470137003312 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 470137003313 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 470137003314 Walker A/P-loop; other site 470137003315 ATP binding site [chemical binding]; other site 470137003316 Q-loop/lid; other site 470137003317 ABC transporter signature motif; other site 470137003318 Walker B; other site 470137003319 D-loop; other site 470137003320 H-loop/switch region; other site 470137003321 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 470137003322 hypothetical protein; Validated; Region: PRK00110 470137003323 Transcriptional regulators [Transcription]; Region: GntR; COG1802 470137003324 FCD domain; Region: FCD; pfam07729 470137003325 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 470137003326 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 470137003327 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 470137003328 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 470137003329 putative active site [active] 470137003330 metal binding site [ion binding]; metal-binding site 470137003331 homodimer binding site [polypeptide binding]; other site 470137003332 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 470137003333 Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division, chromosome partitioning]; Region: zapA; COG3027 470137003334 Domain of unknown function (DUF4164); Region: DUF4164; pfam13747 470137003335 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 470137003336 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 470137003337 TPP-binding site [chemical binding]; other site 470137003338 dimer interface [polypeptide binding]; other site 470137003339 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 470137003340 PYR/PP interface [polypeptide binding]; other site 470137003341 dimer interface [polypeptide binding]; other site 470137003342 TPP binding site [chemical binding]; other site 470137003343 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 470137003344 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 470137003345 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 470137003346 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 470137003347 Phosphoglycerate kinase; Region: PGK; pfam00162 470137003348 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 470137003349 substrate binding site [chemical binding]; other site 470137003350 hinge regions; other site 470137003351 ADP binding site [chemical binding]; other site 470137003352 catalytic site [active] 470137003353 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 470137003354 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 470137003355 acyl-activating enzyme (AAE) consensus motif; other site 470137003356 putative AMP binding site [chemical binding]; other site 470137003357 putative active site [active] 470137003358 putative CoA binding site [chemical binding]; other site 470137003359 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 470137003360 Predicted transcriptional regulator [Transcription]; Region: COG2378 470137003361 HTH domain; Region: HTH_11; pfam08279 470137003362 WYL domain; Region: WYL; pfam13280 470137003363 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 470137003364 CoenzymeA binding site [chemical binding]; other site 470137003365 subunit interaction site [polypeptide binding]; other site 470137003366 PHB binding site; other site 470137003367 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 470137003368 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820 470137003369 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 470137003370 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 470137003371 NAD(P) binding site [chemical binding]; other site 470137003372 Uncharacterized small protein containing a coiled-coil domain [Function unknown]; Region: COG5509 470137003373 putative MFS family transporter protein; Provisional; Region: PRK03633 470137003374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 470137003375 putative substrate translocation pore; other site 470137003376 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 470137003377 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 470137003378 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 470137003379 Uncharacterized small protein [Function unknown]; Region: COG5570 470137003380 Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481 470137003381 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 470137003382 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 470137003383 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 470137003384 NAD binding site [chemical binding]; other site 470137003385 ATP-grasp domain; Region: ATP-grasp; pfam02222 470137003386 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 470137003387 TPR repeat; Region: TPR_11; pfam13414 470137003388 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 470137003389 TPR motif; other site 470137003390 binding surface 470137003391 pyruvate kinase; Provisional; Region: PRK06247 470137003392 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 470137003393 domain interfaces; other site 470137003394 active site 470137003395 Predicted integral membrane protein [Function unknown]; Region: COG5480 470137003396 Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931 470137003397 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3750 470137003398 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 470137003399 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 470137003400 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 470137003401 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 470137003402 Thiamine pyrophosphokinase; Region: TPK; cd07995 470137003403 active site 470137003404 dimerization interface [polypeptide binding]; other site 470137003405 thiamine binding site [chemical binding]; other site 470137003406 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 470137003407 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 470137003408 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 470137003409 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137003410 dimer interface [polypeptide binding]; other site 470137003411 conserved gate region; other site 470137003412 putative PBP binding loops; other site 470137003413 ABC-ATPase subunit interface; other site 470137003414 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137003415 dimer interface [polypeptide binding]; other site 470137003416 conserved gate region; other site 470137003417 putative PBP binding loops; other site 470137003418 ABC-ATPase subunit interface; other site 470137003419 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 470137003420 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 470137003421 Walker A/P-loop; other site 470137003422 ATP binding site [chemical binding]; other site 470137003423 Q-loop/lid; other site 470137003424 ABC transporter signature motif; other site 470137003425 Walker B; other site 470137003426 D-loop; other site 470137003427 H-loop/switch region; other site 470137003428 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 470137003429 Peptidase family M48; Region: Peptidase_M48; pfam01435 470137003430 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 470137003431 MOSC domain; Region: MOSC; pfam03473 470137003432 3-alpha domain; Region: 3-alpha; pfam03475 470137003433 RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500 470137003434 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 470137003435 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 470137003436 DNA binding residues [nucleotide binding] 470137003437 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 470137003438 Ferredoxin [Energy production and conversion]; Region: COG1146 470137003439 4Fe-4S binding domain; Region: Fer4; pfam00037 470137003440 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 470137003441 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 470137003442 RNA binding surface [nucleotide binding]; other site 470137003443 DEAD/DEAH box helicase; Region: DEAD; pfam00270 470137003444 ATP binding site [chemical binding]; other site 470137003445 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 470137003446 putative Mg++ binding site [ion binding]; other site 470137003447 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 470137003448 nucleotide binding region [chemical binding]; other site 470137003449 ATP-binding site [chemical binding]; other site 470137003450 putative acyltransferase; Provisional; Region: PRK05790 470137003451 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 470137003452 dimer interface [polypeptide binding]; other site 470137003453 active site 470137003454 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 470137003455 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 470137003456 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 470137003457 Transglycosylase; Region: Transgly; pfam00912 470137003458 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 470137003459 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 470137003460 substrate binding pocket [chemical binding]; other site 470137003461 chain length determination region; other site 470137003462 substrate-Mg2+ binding site; other site 470137003463 catalytic residues [active] 470137003464 aspartate-rich region 1; other site 470137003465 active site lid residues [active] 470137003466 aspartate-rich region 2; other site 470137003467 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 470137003468 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 470137003469 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 470137003470 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 470137003471 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 470137003472 NAD(P) binding site [chemical binding]; other site 470137003473 active site 470137003474 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 470137003475 Major Facilitator Superfamily; Region: MFS_1; pfam07690 470137003476 putative substrate translocation pore; other site 470137003477 pyruvate carboxylase; Reviewed; Region: PRK12999 470137003478 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 470137003479 ATP-grasp domain; Region: ATP-grasp_4; cl17255 470137003480 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 470137003481 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 470137003482 active site 470137003483 catalytic residues [active] 470137003484 metal binding site [ion binding]; metal-binding site 470137003485 homodimer binding site [polypeptide binding]; other site 470137003486 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 470137003487 carboxyltransferase (CT) interaction site; other site 470137003488 biotinylation site [posttranslational modification]; other site 470137003489 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 470137003490 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 470137003491 dimerization interface [polypeptide binding]; other site 470137003492 ligand binding site [chemical binding]; other site 470137003493 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 470137003494 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 470137003495 dimerization interface [polypeptide binding]; other site 470137003496 ligand binding site [chemical binding]; other site 470137003497 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 470137003498 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 470137003499 Walker A/P-loop; other site 470137003500 ATP binding site [chemical binding]; other site 470137003501 Q-loop/lid; other site 470137003502 ABC transporter signature motif; other site 470137003503 Walker B; other site 470137003504 D-loop; other site 470137003505 H-loop/switch region; other site 470137003506 Uncharacterized conserved protein [Function unknown]; Region: COG3743 470137003507 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 470137003508 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 470137003509 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 470137003510 TM-ABC transporter signature motif; other site 470137003511 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 470137003512 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 470137003513 TM-ABC transporter signature motif; other site 470137003514 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 470137003515 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 470137003516 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 470137003517 Transcriptional regulators [Transcription]; Region: FadR; COG2186 470137003518 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 470137003519 DNA-binding site [nucleotide binding]; DNA binding site 470137003520 FCD domain; Region: FCD; pfam07729 470137003521 MarR family; Region: MarR; pfam01047 470137003522 transcriptional regulator SlyA; Provisional; Region: PRK03573 470137003523 F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]; Region: AtpC; COG0355 470137003524 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 470137003525 gamma subunit interface [polypeptide binding]; other site 470137003526 epsilon subunit interface [polypeptide binding]; other site 470137003527 LBP interface [polypeptide binding]; other site 470137003528 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 470137003529 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 470137003530 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 470137003531 alpha subunit interaction interface [polypeptide binding]; other site 470137003532 Walker A motif; other site 470137003533 ATP binding site [chemical binding]; other site 470137003534 Walker B motif; other site 470137003535 inhibitor binding site; inhibition site 470137003536 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 470137003537 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 470137003538 core domain interface [polypeptide binding]; other site 470137003539 delta subunit interface [polypeptide binding]; other site 470137003540 epsilon subunit interface [polypeptide binding]; other site 470137003541 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 470137003542 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 470137003543 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 470137003544 beta subunit interaction interface [polypeptide binding]; other site 470137003545 Walker A motif; other site 470137003546 ATP binding site [chemical binding]; other site 470137003547 Walker B motif; other site 470137003548 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 470137003549 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 470137003550 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 470137003551 primosome assembly protein PriA; Validated; Region: PRK05580 470137003552 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 470137003553 ATP binding site [chemical binding]; other site 470137003554 putative Mg++ binding site [ion binding]; other site 470137003555 helicase superfamily c-terminal domain; Region: HELICc; smart00490 470137003556 nucleotide binding region [chemical binding]; other site 470137003557 ATP-binding site [chemical binding]; other site 470137003558 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 470137003559 active site 470137003560 intersubunit interactions; other site 470137003561 catalytic residue [active] 470137003562 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5468 470137003563 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 470137003564 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 470137003565 HIGH motif; other site 470137003566 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 470137003567 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 470137003568 active site 470137003569 KMSKS motif; other site 470137003570 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 470137003571 tRNA binding surface [nucleotide binding]; other site 470137003572 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 470137003573 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 470137003574 catalytic residue [active] 470137003575 Predicted membrane protein [Function unknown]; Region: COG1289 470137003576 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 470137003577 Usg protein, probable subunit of phosphoribosylanthranilate isomerase [Amino acid transport and metabolism]; Region: COG5425 470137003578 acetyl-CoA synthetase; Provisional; Region: PRK00174 470137003579 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 470137003580 active site 470137003581 CoA binding site [chemical binding]; other site 470137003582 acyl-activating enzyme (AAE) consensus motif; other site 470137003583 AMP binding site [chemical binding]; other site 470137003584 acetate binding site [chemical binding]; other site 470137003585 Uncharacterized conserved small protein [Function unknown]; Region: COG5508 470137003586 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 470137003587 heat shock protein HtpX; Provisional; Region: PRK01345 470137003588 NusB family; Region: NusB; pfam01029 470137003589 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 470137003590 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 470137003591 S-adenosylmethionine binding site [chemical binding]; other site 470137003592 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5360 470137003593 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 470137003594 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 470137003595 purine monophosphate binding site [chemical binding]; other site 470137003596 dimer interface [polypeptide binding]; other site 470137003597 putative catalytic residues [active] 470137003598 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 470137003599 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 470137003600 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 470137003601 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 470137003602 Predicted membrane protein [Function unknown]; Region: COG3762 470137003603 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 470137003604 Repair protein; Region: Repair_PSII; pfam04536 470137003605 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 470137003606 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 470137003607 chorismate mutase; Provisional; Region: PRK09239 470137003608 signal recognition particle protein; Provisional; Region: PRK10867 470137003609 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 470137003610 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 470137003611 P loop; other site 470137003612 GTP binding site [chemical binding]; other site 470137003613 Signal peptide binding domain; Region: SRP_SPB; pfam02978 470137003614 lytic murein transglycosylase; Region: MltB_2; TIGR02283 470137003615 murein hydrolase B; Provisional; Region: PRK10760; cl17906 470137003616 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 470137003617 active site clefts [active] 470137003618 zinc binding site [ion binding]; other site 470137003619 dimer interface [polypeptide binding]; other site 470137003620 pyridoxamine kinase; Validated; Region: PRK05756 470137003621 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 470137003622 dimer interface [polypeptide binding]; other site 470137003623 pyridoxal binding site [chemical binding]; other site 470137003624 ATP binding site [chemical binding]; other site 470137003625 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 470137003626 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 470137003627 tetrameric interface [polypeptide binding]; other site 470137003628 NAD binding site [chemical binding]; other site 470137003629 catalytic residues [active] 470137003630 Transcriptional regulator [Transcription]; Region: LysR; COG0583 470137003631 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 470137003632 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 470137003633 putative effector binding pocket; other site 470137003634 dimerization interface [polypeptide binding]; other site 470137003635 Predicted membrane protein [Function unknown]; Region: COG3619 470137003636 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 470137003637 putative active site [active] 470137003638 Ap4A binding site [chemical binding]; other site 470137003639 nudix motif; other site 470137003640 putative metal binding site [ion binding]; other site 470137003641 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 470137003642 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 470137003643 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 470137003644 protein binding site [polypeptide binding]; other site 470137003645 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 470137003646 Catalytic dyad [active] 470137003647 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 470137003648 Peptidase family M23; Region: Peptidase_M23; pfam01551 470137003649 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 470137003650 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 470137003651 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 470137003652 active site 470137003653 (T/H)XGH motif; other site 470137003654 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 470137003655 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 470137003656 putative catalytic cysteine [active] 470137003657 gamma-glutamyl kinase; Provisional; Region: PRK05429 470137003658 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 470137003659 nucleotide binding site [chemical binding]; other site 470137003660 homotetrameric interface [polypeptide binding]; other site 470137003661 putative phosphate binding site [ion binding]; other site 470137003662 putative allosteric binding site; other site 470137003663 PUA domain; Region: PUA; pfam01472 470137003664 GTPase CgtA; Reviewed; Region: obgE; PRK12299 470137003665 GTP1/OBG; Region: GTP1_OBG; pfam01018 470137003666 Obg GTPase; Region: Obg; cd01898 470137003667 G1 box; other site 470137003668 GTP/Mg2+ binding site [chemical binding]; other site 470137003669 Switch I region; other site 470137003670 G2 box; other site 470137003671 G3 box; other site 470137003672 Switch II region; other site 470137003673 G4 box; other site 470137003674 G5 box; other site 470137003675 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 470137003676 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 470137003677 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 470137003678 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 470137003679 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 470137003680 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 470137003681 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 470137003682 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 470137003683 Integrase core domain; Region: rve; pfam00665 470137003684 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 470137003685 non-specific DNA binding site [nucleotide binding]; other site 470137003686 salt bridge; other site 470137003687 sequence-specific DNA binding site [nucleotide binding]; other site 470137003688 Cupin domain; Region: Cupin_2; cl17218 470137003689 Methyltransferase domain; Region: Methyltransf_31; pfam13847 470137003690 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 470137003691 S-adenosylmethionine binding site [chemical binding]; other site 470137003692 AzlC protein; Region: AzlC; pfam03591 470137003693 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 470137003694 Integrase core domain; Region: rve; pfam00665 470137003695 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 470137003696 Rrf2 family protein; Region: rrf2_super; TIGR00738 470137003697 Transcriptional regulator; Region: Rrf2; pfam02082 470137003698 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 470137003699 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 470137003700 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 470137003701 ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531 470137003702 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 470137003703 metal binding site [ion binding]; metal-binding site 470137003704 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 470137003705 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 470137003706 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 470137003707 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 470137003708 ABC-ATPase subunit interface; other site 470137003709 dimer interface [polypeptide binding]; other site 470137003710 putative PBP binding regions; other site 470137003711 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 470137003712 metal binding site 2 [ion binding]; metal-binding site 470137003713 putative DNA binding helix; other site 470137003714 metal binding site 1 [ion binding]; metal-binding site 470137003715 dimer interface [polypeptide binding]; other site 470137003716 structural Zn2+ binding site [ion binding]; other site 470137003717 PilZ domain; Region: PilZ; cl01260 470137003718 Rod binding protein; Region: Rod-binding; pfam10135 470137003719 flagellar biosynthesis protein FlhA; Reviewed; Region: flhA; PRK12792 470137003720 FHIPEP family; Region: FHIPEP; pfam00771 470137003721 flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010 470137003722 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009 470137003723 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 470137003724 Flagellar biosynthesis regulator FlbT [Cell motility and secretion]; Region: FlbT; COG5443 470137003725 Flagellar biosynthesis regulator FlaF [Cell motility and secretion]; Region: FlaF; COG5442 470137003726 flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793 470137003727 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008 470137003728 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 470137003729 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 470137003730 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 470137003731 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 470137003732 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 470137003733 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 470137003734 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 470137003735 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 470137003736 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 470137003737 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 470137003738 DNA binding site [nucleotide binding] 470137003739 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 470137003740 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 470137003741 N-acetyl-D-glucosamine binding site [chemical binding]; other site 470137003742 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 470137003743 chemotaxis protein; Reviewed; Region: PRK12798 470137003744 flagellar motor protein MotB; Validated; Region: motB; PRK05996 470137003745 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 470137003746 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 470137003747 ligand binding site [chemical binding]; other site 470137003748 flagellin; Reviewed; Region: PRK12687 470137003749 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 470137003750 Uncharacterized conserved protein [Function unknown]; Region: COG3268 470137003751 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 470137003752 D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634 470137003753 putative ligand binding site [chemical binding]; other site 470137003754 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 470137003755 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 470137003756 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 470137003757 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 470137003758 TM-ABC transporter signature motif; other site 470137003759 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 470137003760 HTH domain; Region: HTH_11; cl17392 470137003761 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 470137003762 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 470137003763 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 470137003764 NAD(P) binding site [chemical binding]; other site 470137003765 catalytic residues [active] 470137003766 choline dehydrogenase; Validated; Region: PRK02106 470137003767 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 470137003768 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 470137003769 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 470137003770 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 470137003771 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 470137003772 N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266 470137003773 tetramer interface [polypeptide binding]; other site 470137003774 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 470137003775 tetramer interface [polypeptide binding]; other site 470137003776 active site 470137003777 metal binding site [ion binding]; metal-binding site 470137003778 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 470137003779 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 470137003780 NAD binding site [chemical binding]; other site 470137003781 catalytic residues [active] 470137003782 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 470137003783 putative substrate binding pocket [chemical binding]; other site 470137003784 trimer interface [polypeptide binding]; other site 470137003785 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 470137003786 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 470137003787 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 470137003788 active site 470137003789 ATP binding site [chemical binding]; other site 470137003790 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 470137003791 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 470137003792 inhibitor-cofactor binding pocket; inhibition site 470137003793 pyridoxal 5'-phosphate binding site [chemical binding]; other site 470137003794 catalytic residue [active] 470137003795 hypothetical protein; Provisional; Region: PRK07481 470137003796 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 470137003797 inhibitor-cofactor binding pocket; inhibition site 470137003798 pyridoxal 5'-phosphate binding site [chemical binding]; other site 470137003799 catalytic residue [active] 470137003800 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 470137003801 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 470137003802 motif II; other site 470137003803 Uncharacterized conserved protein [Function unknown]; Region: COG5441; cl02262 470137003804 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 470137003805 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 470137003806 Transcriptional regulator [Transcription]; Region: IclR; COG1414 470137003807 Bacterial transcriptional regulator; Region: IclR; pfam01614 470137003808 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 470137003809 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 470137003810 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 470137003811 NAD(P) binding site [chemical binding]; other site 470137003812 catalytic residues [active] 470137003813 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 470137003814 Amidohydrolase family; Region: Amidohydro_3; pfam07969 470137003815 active site 470137003816 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 470137003817 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 470137003818 putative ligand binding site [chemical binding]; other site 470137003819 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 470137003820 TM-ABC transporter signature motif; other site 470137003821 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 470137003822 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 470137003823 TM-ABC transporter signature motif; other site 470137003824 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 470137003825 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 470137003826 Walker A/P-loop; other site 470137003827 ATP binding site [chemical binding]; other site 470137003828 Q-loop/lid; other site 470137003829 ABC transporter signature motif; other site 470137003830 Walker B; other site 470137003831 D-loop; other site 470137003832 H-loop/switch region; other site 470137003833 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 470137003834 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 470137003835 Walker A/P-loop; other site 470137003836 ATP binding site [chemical binding]; other site 470137003837 Q-loop/lid; other site 470137003838 ABC transporter signature motif; other site 470137003839 Walker B; other site 470137003840 D-loop; other site 470137003841 H-loop/switch region; other site 470137003842 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 470137003843 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 470137003844 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 470137003845 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 470137003846 DNA-binding site [nucleotide binding]; DNA binding site 470137003847 UTRA domain; Region: UTRA; pfam07702 470137003848 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 470137003849 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 470137003850 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 470137003851 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137003852 dimer interface [polypeptide binding]; other site 470137003853 conserved gate region; other site 470137003854 putative PBP binding loops; other site 470137003855 ABC-ATPase subunit interface; other site 470137003856 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137003857 dimer interface [polypeptide binding]; other site 470137003858 conserved gate region; other site 470137003859 putative PBP binding loops; other site 470137003860 ABC-ATPase subunit interface; other site 470137003861 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 470137003862 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 470137003863 Walker A/P-loop; other site 470137003864 ATP binding site [chemical binding]; other site 470137003865 Q-loop/lid; other site 470137003866 ABC transporter signature motif; other site 470137003867 Walker B; other site 470137003868 D-loop; other site 470137003869 H-loop/switch region; other site 470137003870 TOBE domain; Region: TOBE_2; pfam08402 470137003871 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 470137003872 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 470137003873 active site 470137003874 metal binding site [ion binding]; metal-binding site 470137003875 Sulfatase; Region: Sulfatase; cl17466 470137003876 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 470137003877 NMT1-like family; Region: NMT1_2; pfam13379 470137003878 substrate binding pocket [chemical binding]; other site 470137003879 membrane-bound complex binding site; other site 470137003880 hinge residues; other site 470137003881 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 470137003882 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 470137003883 Walker A/P-loop; other site 470137003884 ATP binding site [chemical binding]; other site 470137003885 Q-loop/lid; other site 470137003886 ABC transporter signature motif; other site 470137003887 Walker B; other site 470137003888 D-loop; other site 470137003889 H-loop/switch region; other site 470137003890 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 470137003891 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137003892 dimer interface [polypeptide binding]; other site 470137003893 conserved gate region; other site 470137003894 putative PBP binding loops; other site 470137003895 ABC-ATPase subunit interface; other site 470137003896 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 470137003897 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 470137003898 nucleotide binding site [chemical binding]; other site 470137003899 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 470137003900 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 470137003901 N-terminal plug; other site 470137003902 ligand-binding site [chemical binding]; other site 470137003903 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 470137003904 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 470137003905 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 470137003906 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_5; cd06338 470137003907 putative ligand binding site [chemical binding]; other site 470137003908 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 470137003909 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 470137003910 TM-ABC transporter signature motif; other site 470137003911 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 470137003912 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 470137003913 TM-ABC transporter signature motif; other site 470137003914 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 470137003915 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 470137003916 Walker A/P-loop; other site 470137003917 ATP binding site [chemical binding]; other site 470137003918 Q-loop/lid; other site 470137003919 ABC transporter signature motif; other site 470137003920 Walker B; other site 470137003921 D-loop; other site 470137003922 H-loop/switch region; other site 470137003923 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 470137003924 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 470137003925 Walker A/P-loop; other site 470137003926 ATP binding site [chemical binding]; other site 470137003927 Q-loop/lid; other site 470137003928 ABC transporter signature motif; other site 470137003929 Walker B; other site 470137003930 D-loop; other site 470137003931 H-loop/switch region; other site 470137003932 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 470137003933 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 470137003934 Soluble P-type ATPase [General function prediction only]; Region: COG4087 470137003935 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 470137003936 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 470137003937 FeS/SAM binding site; other site 470137003938 HemN C-terminal domain; Region: HemN_C; pfam06969 470137003939 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 470137003940 MerR family regulatory protein; Region: MerR; pfam00376 470137003941 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 470137003942 P-loop; other site 470137003943 Magnesium ion binding site [ion binding]; other site 470137003944 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 470137003945 P-loop; other site 470137003946 Magnesium ion binding site [ion binding]; other site 470137003947 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 470137003948 ParB-like nuclease domain; Region: ParB; smart00470 470137003949 DnaA N-terminal domain; Region: DnaA_N; pfam11638 470137003950 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 470137003951 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 470137003952 Walker A motif; other site 470137003953 ATP binding site [chemical binding]; other site 470137003954 Walker B motif; other site 470137003955 arginine finger; other site 470137003956 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 470137003957 DnaA box-binding interface [nucleotide binding]; other site 470137003958 DNA polymerase III subunit beta; Validated; Region: PRK05643 470137003959 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 470137003960 putative DNA binding surface [nucleotide binding]; other site 470137003961 dimer interface [polypeptide binding]; other site 470137003962 beta-clamp/clamp loader binding surface; other site 470137003963 beta-clamp/translesion DNA polymerase binding surface; other site 470137003964 recombination protein F; Reviewed; Region: recF; PRK00064 470137003965 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 470137003966 Walker A/P-loop; other site 470137003967 ATP binding site [chemical binding]; other site 470137003968 Q-loop/lid; other site 470137003969 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 470137003970 ABC transporter signature motif; other site 470137003971 Walker B; other site 470137003972 D-loop; other site 470137003973 H-loop/switch region; other site 470137003974 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 470137003975 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 470137003976 ATP binding site [chemical binding]; other site 470137003977 substrate interface [chemical binding]; other site 470137003978 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 470137003979 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 470137003980 putative ligand binding site [chemical binding]; other site 470137003981 NAD binding site [chemical binding]; other site 470137003982 dimerization interface [polypeptide binding]; other site 470137003983 catalytic site [active] 470137003984 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 470137003985 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 470137003986 Walker A/P-loop; other site 470137003987 ATP binding site [chemical binding]; other site 470137003988 Q-loop/lid; other site 470137003989 ABC transporter signature motif; other site 470137003990 Walker B; other site 470137003991 D-loop; other site 470137003992 H-loop/switch region; other site 470137003993 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 470137003994 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 470137003995 Walker A/P-loop; other site 470137003996 ATP binding site [chemical binding]; other site 470137003997 Q-loop/lid; other site 470137003998 ABC transporter signature motif; other site 470137003999 Walker B; other site 470137004000 D-loop; other site 470137004001 H-loop/switch region; other site 470137004002 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 470137004003 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 470137004004 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137004005 dimer interface [polypeptide binding]; other site 470137004006 conserved gate region; other site 470137004007 putative PBP binding loops; other site 470137004008 ABC-ATPase subunit interface; other site 470137004009 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 470137004010 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137004011 dimer interface [polypeptide binding]; other site 470137004012 conserved gate region; other site 470137004013 putative PBP binding loops; other site 470137004014 ABC-ATPase subunit interface; other site 470137004015 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 470137004016 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 470137004017 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 470137004018 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 470137004019 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 470137004020 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 470137004021 dimerization interface [polypeptide binding]; other site 470137004022 ligand binding site [chemical binding]; other site 470137004023 enoyl-CoA hydratase; Provisional; Region: PRK07468 470137004024 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 470137004025 substrate binding site [chemical binding]; other site 470137004026 oxyanion hole (OAH) forming residues; other site 470137004027 trimer interface [polypeptide binding]; other site 470137004028 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 470137004029 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 470137004030 active site 470137004031 catalytic residues [active] 470137004032 metal binding site [ion binding]; metal-binding site 470137004033 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 470137004034 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 470137004035 ATP-grasp domain; Region: ATP-grasp_4; cl17255 470137004036 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 470137004037 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 470137004038 carboxyltransferase (CT) interaction site; other site 470137004039 biotinylation site [posttranslational modification]; other site 470137004040 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 470137004041 isovaleryl-CoA dehydrogenase; Region: PLN02519 470137004042 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 470137004043 substrate binding site [chemical binding]; other site 470137004044 FAD binding site [chemical binding]; other site 470137004045 catalytic base [active] 470137004046 CHRD domain; Region: CHRD; pfam07452 470137004047 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4530 470137004048 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 470137004049 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 470137004050 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 470137004051 hinge; other site 470137004052 active site 470137004053 cytidylate kinase; Provisional; Region: cmk; PRK00023 470137004054 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 470137004055 CMP-binding site; other site 470137004056 The sites determining sugar specificity; other site 470137004057 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 470137004058 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 470137004059 RNA binding site [nucleotide binding]; other site 470137004060 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 470137004061 RNA binding site [nucleotide binding]; other site 470137004062 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 470137004063 RNA binding site [nucleotide binding]; other site 470137004064 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 470137004065 RNA binding site [nucleotide binding]; other site 470137004066 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 470137004067 RNA binding site [nucleotide binding]; other site 470137004068 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 470137004069 RNA binding site [nucleotide binding]; other site 470137004070 Predicted membrane protein [Function unknown]; Region: COG2855 470137004071 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 470137004072 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 470137004073 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 470137004074 putative dimerization interface [polypeptide binding]; other site 470137004075 lytic murein transglycosylase; Region: MltB_2; TIGR02283 470137004076 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 470137004077 N-acetyl-D-glucosamine binding site [chemical binding]; other site 470137004078 recombination protein RecR; Reviewed; Region: recR; PRK00076 470137004079 RecR protein; Region: RecR; pfam02132 470137004080 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 470137004081 putative active site [active] 470137004082 putative metal-binding site [ion binding]; other site 470137004083 tetramer interface [polypeptide binding]; other site 470137004084 hypothetical protein; Validated; Region: PRK00153 470137004085 DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111 470137004086 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 470137004087 Walker A motif; other site 470137004088 ATP binding site [chemical binding]; other site 470137004089 Walker B motif; other site 470137004090 arginine finger; other site 470137004091 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 470137004092 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 470137004093 HIT domain; Region: HIT; pfam01230 470137004094 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 470137004095 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 470137004096 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 470137004097 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 470137004098 putative NADH binding site [chemical binding]; other site 470137004099 putative active site [active] 470137004100 nudix motif; other site 470137004101 putative metal binding site [ion binding]; other site 470137004102 prephenate dehydratase; Provisional; Region: PRK11899 470137004103 Prephenate dehydratase; Region: PDT; pfam00800 470137004104 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 470137004105 putative L-Phe binding site [chemical binding]; other site 470137004106 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 470137004107 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 470137004108 Ligand binding site; other site 470137004109 oligomer interface; other site 470137004110 Cytochrome c2 [Energy production and conversion]; Region: COG3474 470137004111 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 470137004112 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 470137004113 putative MPT binding site; other site 470137004114 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 470137004115 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 470137004116 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 470137004117 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 470137004118 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 470137004119 D-pathway; other site 470137004120 Putative ubiquinol binding site [chemical binding]; other site 470137004121 Low-spin heme (heme b) binding site [chemical binding]; other site 470137004122 Putative water exit pathway; other site 470137004123 Binuclear center (heme o3/CuB) [ion binding]; other site 470137004124 K-pathway; other site 470137004125 Putative proton exit pathway; other site 470137004126 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 470137004127 Subunit I/III interface [polypeptide binding]; other site 470137004128 Subunit III/IV interface [polypeptide binding]; other site 470137004129 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 470137004130 Bacterial SH3 domain; Region: SH3_3; pfam08239 470137004131 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 470137004132 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 470137004133 Surface antigen; Region: Bac_surface_Ag; pfam01103 470137004134 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 470137004135 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 470137004136 Family of unknown function (DUF490); Region: DUF490; pfam04357 470137004137 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 470137004138 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 470137004139 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 470137004140 Copper(I)-binding protein [Inorganic ion transport and metabolism]; Region: COG2847 470137004141 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 470137004142 dimer interface [polypeptide binding]; other site 470137004143 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 470137004144 active site 470137004145 metal binding site [ion binding]; metal-binding site 470137004146 glutathione binding site [chemical binding]; other site 470137004147 Domain of unknown function DUF59; Region: DUF59; pfam01883 470137004148 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 470137004149 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 470137004150 Walker A motif; other site 470137004151 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 470137004152 phosphoglucomutase; Region: PLN02307 470137004153 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 470137004154 substrate binding site [chemical binding]; other site 470137004155 dimer interface [polypeptide binding]; other site 470137004156 active site 470137004157 metal binding site [ion binding]; metal-binding site 470137004158 Transcriptional regulator [Transcription]; Region: LysR; COG0583 470137004159 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 470137004160 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 470137004161 putative effector binding pocket; other site 470137004162 putative dimerization interface [polypeptide binding]; other site 470137004163 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 470137004164 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 470137004165 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 470137004166 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 470137004167 active site 470137004168 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 470137004169 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 470137004170 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 470137004171 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 470137004172 N-acetyl-D-glucosamine binding site [chemical binding]; other site 470137004173 catalytic residue [active] 470137004174 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 470137004175 DNA Polymerase Y-family; Region: PolY_like; cd03468 470137004176 active site 470137004177 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 470137004178 DNA binding site [nucleotide binding] 470137004179 Uncharacterized conserved protein [Function unknown]; Region: COG4544 470137004180 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 470137004181 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 470137004182 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 470137004183 trimer interface [polypeptide binding]; other site 470137004184 Haemagglutinin; Region: HIM; pfam05662 470137004185 YadA-like C-terminal region; Region: YadA; pfam03895 470137004186 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 470137004187 argininosuccinate synthase; Provisional; Region: PRK13820 470137004188 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 470137004189 ANP binding site [chemical binding]; other site 470137004190 Substrate Binding Site II [chemical binding]; other site 470137004191 Substrate Binding Site I [chemical binding]; other site 470137004192 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 470137004193 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 470137004194 FeS/SAM binding site; other site 470137004195 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 470137004196 Uncharacterized conserved protein [Function unknown]; Region: COG3339 470137004197 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 470137004198 aromatic arch; other site 470137004199 DCoH dimer interaction site [polypeptide binding]; other site 470137004200 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 470137004201 DCoH tetramer interaction site [polypeptide binding]; other site 470137004202 substrate binding site [chemical binding]; other site 470137004203 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 470137004204 Low molecular weight phosphatase family; Region: LMWPc; cd00115 470137004205 active site 470137004206 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 470137004207 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 470137004208 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 470137004209 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 470137004210 active site 470137004211 catalytic triad [active] 470137004212 oxyanion hole [active] 470137004213 switch loop; other site 470137004214 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 470137004215 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 470137004216 Walker A/P-loop; other site 470137004217 ATP binding site [chemical binding]; other site 470137004218 Q-loop/lid; other site 470137004219 ABC transporter signature motif; other site 470137004220 Walker B; other site 470137004221 D-loop; other site 470137004222 H-loop/switch region; other site 470137004223 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 470137004224 ybhL leader; BSUIS_A0091 470137004225 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 470137004226 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 470137004227 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 470137004228 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 470137004229 Coenzyme A binding pocket [chemical binding]; other site 470137004230 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 470137004231 Uncharacterized secreted protein [Function unknown]; Region: COG5429 470137004232 aconitate hydratase; Validated; Region: PRK09277 470137004233 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 470137004234 substrate binding site [chemical binding]; other site 470137004235 ligand binding site [chemical binding]; other site 470137004236 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 470137004237 substrate binding site [chemical binding]; other site 470137004238 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 470137004239 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 470137004240 Walker A/P-loop; other site 470137004241 ATP binding site [chemical binding]; other site 470137004242 Q-loop/lid; other site 470137004243 ABC transporter signature motif; other site 470137004244 Walker B; other site 470137004245 D-loop; other site 470137004246 H-loop/switch region; other site 470137004247 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmB; COG2386 470137004248 heme exporter protein CcmC; Region: ccmC; TIGR01191 470137004249 heme exporter protein CcmD; Region: cytochro_ccmD; TIGR03141 470137004250 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 470137004251 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 470137004252 catalytic residues [active] 470137004253 central insert; other site 470137004254 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 470137004255 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 470137004256 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 470137004257 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 470137004258 active site 470137004259 phosphorylation site [posttranslational modification] 470137004260 intermolecular recognition site; other site 470137004261 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 470137004262 AsnC family; Region: AsnC_trans_reg; pfam01037 470137004263 Domain of Unknown Function (DUF930); Region: DUF930; pfam06059 470137004264 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604 470137004265 Uncharacterized conserved protein [Function unknown]; Region: COG1434 470137004266 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 470137004267 putative active site [active] 470137004268 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 470137004269 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 470137004270 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 470137004271 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137004272 dimer interface [polypeptide binding]; other site 470137004273 conserved gate region; other site 470137004274 putative PBP binding loops; other site 470137004275 ABC-ATPase subunit interface; other site 470137004276 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137004277 dimer interface [polypeptide binding]; other site 470137004278 conserved gate region; other site 470137004279 putative PBP binding loops; other site 470137004280 ABC-ATPase subunit interface; other site 470137004281 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 470137004282 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 470137004283 Walker A/P-loop; other site 470137004284 ATP binding site [chemical binding]; other site 470137004285 Q-loop/lid; other site 470137004286 ABC transporter signature motif; other site 470137004287 Walker B; other site 470137004288 D-loop; other site 470137004289 H-loop/switch region; other site 470137004290 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 470137004291 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 470137004292 Putative glucoamylase; Region: Glycoamylase; pfam10091 470137004293 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 470137004294 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 470137004295 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 470137004296 Protein of unknown function, DUF608; Region: DUF608; pfam04685 470137004297 Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488 470137004298 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 470137004299 active site 470137004300 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 470137004301 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 470137004302 S-adenosylmethionine binding site [chemical binding]; other site 470137004303 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 470137004304 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 470137004305 putative substrate binding site [chemical binding]; other site 470137004306 putative ATP binding site [chemical binding]; other site 470137004307 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 470137004308 classical (c) SDRs; Region: SDR_c; cd05233 470137004309 NAD(P) binding site [chemical binding]; other site 470137004310 active site 470137004311 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 470137004312 Transglycosylase; Region: Transgly; pfam00912 470137004313 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 470137004314 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 470137004315 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 470137004316 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 470137004317 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 470137004318 catalytic site [active] 470137004319 putative active site [active] 470137004320 putative substrate binding site [chemical binding]; other site 470137004321 hypothetical protein; Validated; Region: PRK09104 470137004322 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 470137004323 metal binding site [ion binding]; metal-binding site 470137004324 putative dimer interface [polypeptide binding]; other site 470137004325 DNA polymerase I; Region: pola; TIGR00593 470137004326 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 470137004327 active site 470137004328 metal binding site 1 [ion binding]; metal-binding site 470137004329 putative 5' ssDNA interaction site; other site 470137004330 metal binding site 3; metal-binding site 470137004331 metal binding site 2 [ion binding]; metal-binding site 470137004332 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 470137004333 putative DNA binding site [nucleotide binding]; other site 470137004334 putative metal binding site [ion binding]; other site 470137004335 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 470137004336 active site 470137004337 catalytic site [active] 470137004338 substrate binding site [chemical binding]; other site 470137004339 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 470137004340 active site 470137004341 DNA binding site [nucleotide binding] 470137004342 catalytic site [active] 470137004343 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 470137004344 DEAD-like helicases superfamily; Region: DEXDc; smart00487 470137004345 ATP binding site [chemical binding]; other site 470137004346 Mg++ binding site [ion binding]; other site 470137004347 motif III; other site 470137004348 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 470137004349 nucleotide binding region [chemical binding]; other site 470137004350 ATP-binding site [chemical binding]; other site 470137004351 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 470137004352 RNA binding site [nucleotide binding]; other site 470137004353 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 470137004354 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 470137004355 Mg2+ binding site [ion binding]; other site 470137004356 G-X-G motif; other site 470137004357 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 470137004358 anchoring element; other site 470137004359 dimer interface [polypeptide binding]; other site 470137004360 ATP binding site [chemical binding]; other site 470137004361 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 470137004362 active site 470137004363 putative metal-binding site [ion binding]; other site 470137004364 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 470137004365 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 470137004366 nucleotide binding region [chemical binding]; other site 470137004367 ATP-binding site [chemical binding]; other site 470137004368 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 470137004369 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 470137004370 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 470137004371 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 470137004372 ATP binding site [chemical binding]; other site 470137004373 Mg2+ binding site [ion binding]; other site 470137004374 G-X-G motif; other site 470137004375 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 470137004376 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 470137004377 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 470137004378 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 470137004379 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 470137004380 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 470137004381 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 470137004382 active site 470137004383 phosphorylation site [posttranslational modification] 470137004384 intermolecular recognition site; other site 470137004385 dimerization interface [polypeptide binding]; other site 470137004386 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 470137004387 Protein of unknown function (DUF1052); Region: DUF1052; cl02197 470137004388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 470137004389 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 470137004390 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 470137004391 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 470137004392 Universal stress protein family; Region: Usp; pfam00582 470137004393 Ligand Binding Site [chemical binding]; other site 470137004394 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 470137004395 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 470137004396 active site 470137004397 HIGH motif; other site 470137004398 dimer interface [polypeptide binding]; other site 470137004399 KMSKS motif; other site 470137004400 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 470137004401 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 470137004402 PII uridylyl-transferase; Provisional; Region: PRK05092 470137004403 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 470137004404 metal binding triad; other site 470137004405 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 470137004406 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 470137004407 Zn2+ binding site [ion binding]; other site 470137004408 Mg2+ binding site [ion binding]; other site 470137004409 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 470137004410 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 470137004411 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 470137004412 MutS domain I; Region: MutS_I; pfam01624 470137004413 MutS domain II; Region: MutS_II; pfam05188 470137004414 MutS domain III; Region: MutS_III; pfam05192 470137004415 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 470137004416 Walker A/P-loop; other site 470137004417 ATP binding site [chemical binding]; other site 470137004418 Q-loop/lid; other site 470137004419 ABC transporter signature motif; other site 470137004420 Walker B; other site 470137004421 D-loop; other site 470137004422 H-loop/switch region; other site 470137004423 Putative hemolysin [General function prediction only]; Region: COG3176 470137004424 lipoprotein signal peptidase; Provisional; Region: PRK14795 470137004425 lipoprotein signal peptidase; Provisional; Region: PRK14787 470137004426 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 470137004427 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 470137004428 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 470137004429 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 470137004430 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 470137004431 S-adenosylmethionine binding site [chemical binding]; other site 470137004432 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 470137004433 IHF dimer interface [polypeptide binding]; other site 470137004434 IHF - DNA interface [nucleotide binding]; other site 470137004435 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 470137004436 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 470137004437 tandem repeat interface [polypeptide binding]; other site 470137004438 oligomer interface [polypeptide binding]; other site 470137004439 active site residues [active] 470137004440 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 470137004441 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 470137004442 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 470137004443 OstA-like protein; Region: OstA; pfam03968 470137004444 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 470137004445 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 470137004446 Walker A/P-loop; other site 470137004447 ATP binding site [chemical binding]; other site 470137004448 Q-loop/lid; other site 470137004449 ABC transporter signature motif; other site 470137004450 Walker B; other site 470137004451 D-loop; other site 470137004452 H-loop/switch region; other site 470137004453 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 470137004454 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 470137004455 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 470137004456 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 470137004457 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 470137004458 30S subunit binding site; other site 470137004459 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 470137004460 active site 470137004461 phosphorylation site [posttranslational modification] 470137004462 Uncharacterized small protein [Function unknown]; Region: COG5568 470137004463 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 470137004464 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 470137004465 putative dimer interface [polypeptide binding]; other site 470137004466 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 470137004467 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 470137004468 minor groove reading motif; other site 470137004469 helix-hairpin-helix signature motif; other site 470137004470 substrate binding pocket [chemical binding]; other site 470137004471 active site 470137004472 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 470137004473 CysZ-like protein; Reviewed; Region: PRK12768 470137004474 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 470137004475 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 470137004476 substrate binding site [chemical binding]; other site 470137004477 ATP binding site [chemical binding]; other site 470137004478 Predicted membrane protein [Function unknown]; Region: COG2860 470137004479 UPF0126 domain; Region: UPF0126; pfam03458 470137004480 UPF0126 domain; Region: UPF0126; pfam03458 470137004481 heat shock protein GrpE; Provisional; Region: PRK14141 470137004482 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 470137004483 dimer interface [polypeptide binding]; other site 470137004484 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 470137004485 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 470137004486 ribonuclease PH; Reviewed; Region: rph; PRK00173 470137004487 Ribonuclease PH; Region: RNase_PH_bact; cd11362 470137004488 hexamer interface [polypeptide binding]; other site 470137004489 active site 470137004490 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 470137004491 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 470137004492 putative metal binding site [ion binding]; other site 470137004493 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 470137004494 active site 470137004495 dimerization interface [polypeptide binding]; other site 470137004496 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 470137004497 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 470137004498 FeS/SAM binding site; other site 470137004499 HemN C-terminal domain; Region: HemN_C; pfam06969 470137004500 Predicted methyltransferases [General function prediction only]; Region: COG0313 470137004501 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 470137004502 putative SAM binding site [chemical binding]; other site 470137004503 putative homodimer interface [polypeptide binding]; other site 470137004504 hypothetical protein; Reviewed; Region: PRK12497 470137004505 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 470137004506 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 470137004507 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 470137004508 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 470137004509 active site 470137004510 SAM binding site [chemical binding]; other site 470137004511 homodimer interface [polypeptide binding]; other site 470137004512 Protein of unknown function (DUF2849); Region: DUF2849; pfam11011 470137004513 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 470137004514 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 470137004515 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 470137004516 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 470137004517 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 470137004518 Active Sites [active] 470137004519 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3749 470137004520 Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876 470137004521 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 470137004522 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 470137004523 active site 470137004524 DNA binding site [nucleotide binding] 470137004525 BA14K-like protein; Region: BA14K; pfam07886 470137004526 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 470137004527 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 470137004528 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 470137004529 substrate binding pocket [chemical binding]; other site 470137004530 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 470137004531 B12 binding site [chemical binding]; other site 470137004532 cobalt ligand [ion binding]; other site 470137004533 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 470137004534 Dehydratase family; Region: ILVD_EDD; cl00340 470137004535 Autoinducer binding domain; Region: Autoind_bind; pfam03472 470137004536 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 470137004537 DNA binding residues [nucleotide binding] 470137004538 aminotransferase; Provisional; Region: PRK06105 470137004539 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 470137004540 inhibitor-cofactor binding pocket; inhibition site 470137004541 pyridoxal 5'-phosphate binding site [chemical binding]; other site 470137004542 catalytic residue [active] 470137004543 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 470137004544 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 470137004545 Active Sites [active] 470137004546 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 470137004547 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 470137004548 CysD dimerization site [polypeptide binding]; other site 470137004549 G1 box; other site 470137004550 putative GEF interaction site [polypeptide binding]; other site 470137004551 GTP/Mg2+ binding site [chemical binding]; other site 470137004552 Switch I region; other site 470137004553 G2 box; other site 470137004554 G3 box; other site 470137004555 Switch II region; other site 470137004556 G4 box; other site 470137004557 G5 box; other site 470137004558 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 470137004559 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 470137004560 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 470137004561 ligand-binding site [chemical binding]; other site 470137004562 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 470137004563 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 470137004564 active site 470137004565 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 470137004566 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 470137004567 active site 470137004568 dimerization interface [polypeptide binding]; other site 470137004569 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 470137004570 DNA binding residues [nucleotide binding] 470137004571 dimerization interface [polypeptide binding]; other site 470137004572 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 470137004573 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 470137004574 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 470137004575 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 470137004576 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 470137004577 GAF domain; Region: GAF; pfam01590 470137004578 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 470137004579 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 470137004580 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 470137004581 NAD(P) binding site [chemical binding]; other site 470137004582 catalytic residues [active] 470137004583 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 470137004584 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 470137004585 NAD binding site [chemical binding]; other site 470137004586 substrate binding site [chemical binding]; other site 470137004587 catalytic Zn binding site [ion binding]; other site 470137004588 tetramer interface [polypeptide binding]; other site 470137004589 structural Zn binding site [ion binding]; other site 470137004590 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3564 470137004591 Transcriptional regulators [Transcription]; Region: PurR; COG1609 470137004592 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 470137004593 DNA binding site [nucleotide binding] 470137004594 domain linker motif; other site 470137004595 Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545 470137004596 putative dimerization interface [polypeptide binding]; other site 470137004597 putative ligand binding site [chemical binding]; other site 470137004598 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 470137004599 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 470137004600 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 470137004601 Walker A/P-loop; other site 470137004602 ATP binding site [chemical binding]; other site 470137004603 Q-loop/lid; other site 470137004604 ABC transporter signature motif; other site 470137004605 Walker B; other site 470137004606 D-loop; other site 470137004607 H-loop/switch region; other site 470137004608 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 470137004609 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 470137004610 NAD(P) binding site [chemical binding]; other site 470137004611 catalytic residues [active] 470137004612 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 470137004613 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137004614 dimer interface [polypeptide binding]; other site 470137004615 conserved gate region; other site 470137004616 putative PBP binding loops; other site 470137004617 ABC-ATPase subunit interface; other site 470137004618 Putative transcription activator [Transcription]; Region: TenA; COG0819 470137004619 NMT1/THI5 like; Region: NMT1; pfam09084 470137004620 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 470137004621 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 470137004622 active site 470137004623 thiamine phosphate binding site [chemical binding]; other site 470137004624 pyrophosphate binding site [ion binding]; other site 470137004625 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 470137004626 ThiS interaction site; other site 470137004627 putative active site [active] 470137004628 tetramer interface [polypeptide binding]; other site 470137004629 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 470137004630 thiS-thiF/thiG interaction site; other site 470137004631 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 470137004632 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 470137004633 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 470137004634 dimer interface [polypeptide binding]; other site 470137004635 substrate binding site [chemical binding]; other site 470137004636 ATP binding site [chemical binding]; other site 470137004637 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 470137004638 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 470137004639 putative active site [active] 470137004640 heme pocket [chemical binding]; other site 470137004641 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 470137004642 putative active site [active] 470137004643 heme pocket [chemical binding]; other site 470137004644 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 470137004645 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 470137004646 metal binding site [ion binding]; metal-binding site 470137004647 active site 470137004648 I-site; other site 470137004649 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 470137004650 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 470137004651 metal-binding site [ion binding] 470137004652 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 470137004653 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 470137004654 metal-binding site [ion binding] 470137004655 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 470137004656 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 470137004657 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 470137004658 DNA binding residues [nucleotide binding] 470137004659 dimer interface [polypeptide binding]; other site 470137004660 copper binding site [ion binding]; other site 470137004661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137004662 dimer interface [polypeptide binding]; other site 470137004663 conserved gate region; other site 470137004664 putative PBP binding loops; other site 470137004665 ABC-ATPase subunit interface; other site 470137004666 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 470137004667 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 470137004668 Walker A/P-loop; other site 470137004669 ATP binding site [chemical binding]; other site 470137004670 Q-loop/lid; other site 470137004671 ABC transporter signature motif; other site 470137004672 Walker B; other site 470137004673 D-loop; other site 470137004674 H-loop/switch region; other site 470137004675 CBS domain; Region: CBS; pfam00571 470137004676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137004677 dimer interface [polypeptide binding]; other site 470137004678 conserved gate region; other site 470137004679 ABC-ATPase subunit interface; other site 470137004680 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 470137004681 Uncharacterized conserved protein [Function unknown]; Region: COG5514 470137004682 heme-binding site [chemical binding]; other site 470137004683 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 470137004684 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 470137004685 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 470137004686 NAD(P) binding site [chemical binding]; other site 470137004687 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 470137004688 hydroxyglutarate oxidase; Provisional; Region: PRK11728 470137004689 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 470137004690 Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583 470137004691 Transcriptional regulator [Transcription]; Region: IclR; COG1414 470137004692 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 470137004693 putative DNA binding site [nucleotide binding]; other site 470137004694 putative Zn2+ binding site [ion binding]; other site 470137004695 Bacterial transcriptional regulator; Region: IclR; pfam01614 470137004696 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 470137004697 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 470137004698 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137004699 dimer interface [polypeptide binding]; other site 470137004700 conserved gate region; other site 470137004701 putative PBP binding loops; other site 470137004702 ABC-ATPase subunit interface; other site 470137004703 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 470137004704 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137004705 dimer interface [polypeptide binding]; other site 470137004706 conserved gate region; other site 470137004707 putative PBP binding loops; other site 470137004708 ABC-ATPase subunit interface; other site 470137004709 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 470137004710 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 470137004711 Walker A/P-loop; other site 470137004712 ATP binding site [chemical binding]; other site 470137004713 Q-loop/lid; other site 470137004714 ABC transporter signature motif; other site 470137004715 Walker B; other site 470137004716 D-loop; other site 470137004717 H-loop/switch region; other site 470137004718 TOBE domain; Region: TOBE_2; pfam08402 470137004719 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 470137004720 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 470137004721 active site pocket [active] 470137004722 Uncharacterized conserved protein [Function unknown]; Region: COG3254 470137004723 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 470137004724 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 470137004725 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 470137004726 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 470137004727 NAD binding site [chemical binding]; other site 470137004728 homotetramer interface [polypeptide binding]; other site 470137004729 homodimer interface [polypeptide binding]; other site 470137004730 active site 470137004731 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 470137004732 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 470137004733 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 470137004734 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 470137004735 putative active site pocket [active] 470137004736 metal binding site [ion binding]; metal-binding site 470137004737 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 470137004738 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 470137004739 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 470137004740 Toprim domain; Region: Toprim_3; pfam13362 470137004741 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 470137004742 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 470137004743 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 470137004744 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 470137004745 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 470137004746 Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253 470137004747 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 470137004748 non-specific DNA binding site [nucleotide binding]; other site 470137004749 salt bridge; other site 470137004750 sequence-specific DNA binding site [nucleotide binding]; other site 470137004751 TIR domain; Region: TIR_2; pfam13676 470137004752 zinc-binding protein; Provisional; Region: PRK01343 470137004753 Maf-like protein; Region: Maf; pfam02545 470137004754 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 470137004755 active site 470137004756 dimer interface [polypeptide binding]; other site 470137004757 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 470137004758 rRNA binding site [nucleotide binding]; other site 470137004759 predicted 30S ribosome binding site; other site 470137004760 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 470137004761 Low molecular weight phosphatase family; Region: LMWPc; cd00115 470137004762 active site 470137004763 hypothetical protein; Provisional; Region: PRK02853 470137004764 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 470137004765 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 470137004766 NAD binding site [chemical binding]; other site 470137004767 dimerization interface [polypeptide binding]; other site 470137004768 product binding site; other site 470137004769 substrate binding site [chemical binding]; other site 470137004770 zinc binding site [ion binding]; other site 470137004771 catalytic residues [active] 470137004772 Protein of unknown function (DUF2948); Region: DUF2948; pfam11164 470137004773 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 470137004774 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 470137004775 hinge; other site 470137004776 active site 470137004777 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 470137004778 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 470137004779 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 470137004780 active site 470137004781 DNA binding site [nucleotide binding] 470137004782 Int/Topo IB signature motif; other site 470137004783 Prophage antirepressor [Transcription]; Region: COG3617 470137004784 BRO family, N-terminal domain; Region: Bro-N; smart01040 470137004785 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 470137004786 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 470137004787 catalytic residues [active] 470137004788 catalytic nucleophile [active] 470137004789 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 470137004790 DNA-binding interface [nucleotide binding]; DNA binding site 470137004791 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 470137004792 non-specific DNA binding site [nucleotide binding]; other site 470137004793 salt bridge; other site 470137004794 sequence-specific DNA binding site [nucleotide binding]; other site 470137004795 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 470137004796 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 470137004797 alpha-gamma subunit interface [polypeptide binding]; other site 470137004798 beta-gamma subunit interface [polypeptide binding]; other site 470137004799 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 470137004800 gamma-beta subunit interface [polypeptide binding]; other site 470137004801 alpha-beta subunit interface [polypeptide binding]; other site 470137004802 urease subunit alpha; Reviewed; Region: ureC; PRK13207 470137004803 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 470137004804 subunit interactions [polypeptide binding]; other site 470137004805 active site 470137004806 flap region; other site 470137004807 Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371 470137004808 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 470137004809 dimer interface [polypeptide binding]; other site 470137004810 catalytic residues [active] 470137004811 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 470137004812 UreF; Region: UreF; pfam01730 470137004813 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 470137004814 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 470137004815 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 470137004816 ATP binding site [chemical binding]; other site 470137004817 Mg2+ binding site [ion binding]; other site 470137004818 G-X-G motif; other site 470137004819 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 470137004820 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 470137004821 HlyD family secretion protein; Region: HlyD_3; pfam13437 470137004822 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 470137004823 phenylhydantoinase; Validated; Region: PRK08323 470137004824 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 470137004825 tetramer interface [polypeptide binding]; other site 470137004826 active site 470137004827 allantoate amidohydrolase; Reviewed; Region: PRK12893 470137004828 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 470137004829 active site 470137004830 metal binding site [ion binding]; metal-binding site 470137004831 dimer interface [polypeptide binding]; other site 470137004832 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 470137004833 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 470137004834 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 470137004835 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 470137004836 nudix motif; other site 470137004837 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 470137004838 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 470137004839 homodimer interface [polypeptide binding]; other site 470137004840 active site 470137004841 FMN binding site [chemical binding]; other site 470137004842 substrate binding site [chemical binding]; other site 470137004843 4Fe-4S binding domain; Region: Fer4; cl02805 470137004844 4Fe-4S binding domain; Region: Fer4; pfam00037 470137004845 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 470137004846 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 470137004847 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 470137004848 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 470137004849 putative hydrophobic ligand binding site [chemical binding]; other site 470137004850 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 470137004851 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 470137004852 active site 470137004853 dimer interface [polypeptide binding]; other site 470137004854 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 470137004855 dimer interface [polypeptide binding]; other site 470137004856 active site 470137004857 Predicted deacylase [General function prediction only]; Region: COG3608 470137004858 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 470137004859 active site 470137004860 Zn binding site [ion binding]; other site 470137004861 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 470137004862 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 470137004863 motif II; other site 470137004864 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 470137004865 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 470137004866 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 470137004867 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 470137004868 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 470137004869 acyl-activating enzyme (AAE) consensus motif; other site 470137004870 putative AMP binding site [chemical binding]; other site 470137004871 putative active site [active] 470137004872 putative CoA binding site [chemical binding]; other site 470137004873 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 470137004874 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 470137004875 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 470137004876 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 470137004877 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 470137004878 HlyD family secretion protein; Region: HlyD_3; pfam13437 470137004879 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 470137004880 Protein export membrane protein; Region: SecD_SecF; cl14618 470137004881 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 470137004882 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 470137004883 substrate binding pocket [chemical binding]; other site 470137004884 membrane-bound complex binding site; other site 470137004885 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 470137004886 CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427 470137004887 DXD motif; other site 470137004888 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 470137004889 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 470137004890 dimer interface [polypeptide binding]; other site 470137004891 phosphorylation site [posttranslational modification] 470137004892 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 470137004893 ATP binding site [chemical binding]; other site 470137004894 Mg2+ binding site [ion binding]; other site 470137004895 G-X-G motif; other site 470137004896 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5352 470137004897 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 470137004898 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 470137004899 inhibitor-cofactor binding pocket; inhibition site 470137004900 pyridoxal 5'-phosphate binding site [chemical binding]; other site 470137004901 catalytic residue [active] 470137004902 ornithine carbamoyltransferase; Provisional; Region: PRK00779 470137004903 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 470137004904 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 470137004905 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 470137004906 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 470137004907 dimerization interface [polypeptide binding]; other site 470137004908 domain crossover interface; other site 470137004909 redox-dependent activation switch; other site 470137004910 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 470137004911 O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504 470137004912 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 470137004913 homodimer interface [polypeptide binding]; other site 470137004914 substrate-cofactor binding pocket; other site 470137004915 pyridoxal 5'-phosphate binding site [chemical binding]; other site 470137004916 catalytic residue [active] 470137004917 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 470137004918 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 470137004919 trimer interface [polypeptide binding]; other site 470137004920 active site 470137004921 Deoxycytidine deaminase [Nucleotide transport and metabolism]; Region: Dcd; COG0717 470137004922 trimer interface [polypeptide binding]; other site 470137004923 active site 470137004924 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 470137004925 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 470137004926 conserved cys residue [active] 470137004927 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 470137004928 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 470137004929 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 470137004930 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 470137004931 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 470137004932 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 470137004933 quinone interaction residues [chemical binding]; other site 470137004934 active site 470137004935 catalytic residues [active] 470137004936 FMN binding site [chemical binding]; other site 470137004937 substrate binding site [chemical binding]; other site 470137004938 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 470137004939 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 470137004940 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 470137004941 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 470137004942 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 470137004943 active site 470137004944 phosphorylation site [posttranslational modification] 470137004945 intermolecular recognition site; other site 470137004946 dimerization interface [polypeptide binding]; other site 470137004947 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 470137004948 DNA binding residues [nucleotide binding] 470137004949 dimerization interface [polypeptide binding]; other site 470137004950 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 470137004951 Na binding site [ion binding]; other site 470137004952 PAS fold; Region: PAS_7; pfam12860 470137004953 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 470137004954 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 470137004955 dimer interface [polypeptide binding]; other site 470137004956 phosphorylation site [posttranslational modification] 470137004957 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 470137004958 ATP binding site [chemical binding]; other site 470137004959 Mg2+ binding site [ion binding]; other site 470137004960 G-X-G motif; other site 470137004961 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 470137004962 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 470137004963 active site 470137004964 phosphorylation site [posttranslational modification] 470137004965 intermolecular recognition site; other site 470137004966 dimerization interface [polypeptide binding]; other site 470137004967 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 470137004968 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 470137004969 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 470137004970 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 470137004971 substrate-cofactor binding pocket; other site 470137004972 pyridoxal 5'-phosphate binding site [chemical binding]; other site 470137004973 catalytic residue [active] 470137004974 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 470137004975 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 470137004976 putative active site [active] 470137004977 putative metal binding site [ion binding]; other site 470137004978 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 470137004979 Glycosyltransferase family 29 (sialyltransferase); Region: Glyco_transf_29; pfam00777 470137004980 Transcriptional regulator [Transcription]; Region: LysR; COG0583 470137004981 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 470137004982 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 470137004983 putative dimerization interface [polypeptide binding]; other site 470137004984 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 470137004985 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 470137004986 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 470137004987 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 470137004988 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 470137004989 pantoate--beta-alanine ligase; Region: panC; TIGR00018 470137004990 Pantoate-beta-alanine ligase; Region: PanC; cd00560 470137004991 active site 470137004992 ATP-binding site [chemical binding]; other site 470137004993 pantoate-binding site; other site 470137004994 HXXH motif; other site 470137004995 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 470137004996 active site 470137004997 oligomerization interface [polypeptide binding]; other site 470137004998 metal binding site [ion binding]; metal-binding site 470137004999 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 470137005000 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 470137005001 FAD binding pocket [chemical binding]; other site 470137005002 FAD binding motif [chemical binding]; other site 470137005003 phosphate binding motif [ion binding]; other site 470137005004 beta-alpha-beta structure motif; other site 470137005005 NAD binding pocket [chemical binding]; other site 470137005006 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 470137005007 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 470137005008 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 470137005009 dimer interface [polypeptide binding]; other site 470137005010 active site 470137005011 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 470137005012 catalytic residues [active] 470137005013 substrate binding site [chemical binding]; other site 470137005014 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 470137005015 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 470137005016 NAD(P) binding pocket [chemical binding]; other site 470137005017 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 470137005018 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 470137005019 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 470137005020 multidrug efflux protein; Reviewed; Region: PRK01766 470137005021 cation binding site [ion binding]; other site 470137005022 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 470137005023 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 470137005024 Cache domain; Region: Cache_2; pfam08269 470137005025 Histidine kinase; Region: HisKA_3; pfam07730 470137005026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 470137005027 ATP binding site [chemical binding]; other site 470137005028 Mg2+ binding site [ion binding]; other site 470137005029 G-X-G motif; other site 470137005030 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 470137005031 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 470137005032 active site 470137005033 phosphorylation site [posttranslational modification] 470137005034 intermolecular recognition site; other site 470137005035 dimerization interface [polypeptide binding]; other site 470137005036 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 470137005037 DNA binding residues [nucleotide binding] 470137005038 dimerization interface [polypeptide binding]; other site 470137005039 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 470137005040 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 470137005041 DctM-like transporters; Region: DctM; pfam06808 470137005042 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 470137005043 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 470137005044 hypothetical protein; Provisional; Region: PRK11171 470137005045 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 470137005046 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 470137005047 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 470137005048 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 470137005049 active site 470137005050 catalytic site [active] 470137005051 tetramer interface [polypeptide binding]; other site 470137005052 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 470137005053 Transthyretin_like. This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase). TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl17222 470137005054 homotetramer interface [polypeptide binding]; other site 470137005055 active site 470137005056 Xanthine dehydrogenase, molybdopterin-binding subunit B [Nucleotide transport and metabolism]; Region: XdhB; COG4631 470137005057 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 470137005058 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 470137005059 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 470137005060 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 470137005061 XdhC Rossmann domain; Region: XdhC_C; pfam13478 470137005062 Transcriptional regulator [Transcription]; Region: LysR; COG0583 470137005063 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 470137005064 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 470137005065 putative effector binding pocket; other site 470137005066 dimerization interface [polypeptide binding]; other site 470137005067 Predicted membrane protein [Function unknown]; Region: COG3748 470137005068 Protein of unknown function (DUF989); Region: DUF989; pfam06181 470137005069 Cytochrome c; Region: Cytochrom_C; pfam00034 470137005070 guanine deaminase; Provisional; Region: PRK09228 470137005071 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 470137005072 active site 470137005073 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 470137005074 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 470137005075 MOFRL family; Region: MOFRL; pfam05161 470137005076 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 470137005077 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 470137005078 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 470137005079 metal-binding site [ion binding] 470137005080 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 470137005081 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 470137005082 motif II; other site 470137005083 Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456 470137005084 FixH; Region: FixH; pfam05751 470137005085 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 470137005086 4Fe-4S binding domain; Region: Fer4_5; pfam12801 470137005087 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 470137005088 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 470137005089 Cytochrome c; Region: Cytochrom_C; pfam00034 470137005090 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 470137005091 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 470137005092 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 470137005093 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 470137005094 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 470137005095 Low-spin heme binding site [chemical binding]; other site 470137005096 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 470137005097 Putative water exit pathway; other site 470137005098 Binuclear center (active site) [active] 470137005099 Putative proton exit pathway; other site 470137005100 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 470137005101 metal binding site 2 [ion binding]; metal-binding site 470137005102 putative DNA binding helix; other site 470137005103 metal binding site 1 [ion binding]; metal-binding site 470137005104 dimer interface [polypeptide binding]; other site 470137005105 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 470137005106 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 470137005107 catalytic residues [active] 470137005108 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 470137005109 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 470137005110 NAD(P) binding site [chemical binding]; other site 470137005111 catalytic residues [active] 470137005112 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 470137005113 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 470137005114 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 470137005115 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 470137005116 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 470137005117 DNA binding site [nucleotide binding] 470137005118 active site 470137005119 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 470137005120 ArsC family; Region: ArsC; pfam03960 470137005121 putative catalytic residues [active] 470137005122 Predicted membrane protein [Function unknown]; Region: COG4129 470137005123 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 470137005124 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 470137005125 microcin B17 transporter; Reviewed; Region: PRK11098 470137005126 Putative catalytic domain of uncharacterized bacterial hypothetical proteins similar to insect chitin deacetylase-like proteins; Region: CE4_CDA_like_3; cd10976 470137005127 NodB motif; other site 470137005128 putative active site [active] 470137005129 putative catalytic site [active] 470137005130 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 470137005131 GTP-binding protein Der; Reviewed; Region: PRK00093 470137005132 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 470137005133 G1 box; other site 470137005134 GTP/Mg2+ binding site [chemical binding]; other site 470137005135 Switch I region; other site 470137005136 G2 box; other site 470137005137 Switch II region; other site 470137005138 G3 box; other site 470137005139 G4 box; other site 470137005140 G5 box; other site 470137005141 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 470137005142 G1 box; other site 470137005143 GTP/Mg2+ binding site [chemical binding]; other site 470137005144 Switch I region; other site 470137005145 G2 box; other site 470137005146 G3 box; other site 470137005147 Switch II region; other site 470137005148 G4 box; other site 470137005149 G5 box; other site 470137005150 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 470137005151 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 470137005152 nucleotide binding site [chemical binding]; other site 470137005153 putative NEF/HSP70 interaction site [polypeptide binding]; other site 470137005154 SBD interface [polypeptide binding]; other site 470137005155 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 470137005156 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 470137005157 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5336 470137005158 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 470137005159 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 470137005160 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 470137005161 F0F1 ATP synthase subunit B'; Validated; Region: PRK09174 470137005162 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 470137005163 F0F1 ATP synthase subunit B; Validated; Region: PRK09173 470137005164 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 470137005165 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 470137005166 RNA/DNA hybrid binding site [nucleotide binding]; other site 470137005167 active site 470137005168 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 470137005169 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 470137005170 FeS/SAM binding site; other site 470137005171 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 470137005172 active site 470137005173 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 470137005174 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 470137005175 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 470137005176 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 470137005177 tandem repeat interface [polypeptide binding]; other site 470137005178 oligomer interface [polypeptide binding]; other site 470137005179 active site residues [active] 470137005180 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 470137005181 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 470137005182 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 470137005183 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 470137005184 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 470137005185 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 470137005186 substrate binding pocket [chemical binding]; other site 470137005187 chain length determination region; other site 470137005188 substrate-Mg2+ binding site; other site 470137005189 catalytic residues [active] 470137005190 aspartate-rich region 1; other site 470137005191 active site lid residues [active] 470137005192 aspartate-rich region 2; other site 470137005193 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 470137005194 binding surface 470137005195 TPR motif; other site 470137005196 TPR repeat; Region: TPR_11; pfam13414 470137005197 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 470137005198 binding surface 470137005199 TPR repeat; Region: TPR_11; pfam13414 470137005200 TPR motif; other site 470137005201 TPR repeat; Region: TPR_11; pfam13414 470137005202 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 470137005203 dimer interface [polypeptide binding]; other site 470137005204 motif 1; other site 470137005205 active site 470137005206 motif 2; other site 470137005207 motif 3; other site 470137005208 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 470137005209 DALR anticodon binding domain; Region: DALR_1; pfam05746 470137005210 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 470137005211 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 470137005212 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 470137005213 FAD binding domain; Region: FAD_binding_4; pfam01565 470137005214 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 470137005215 Predicted transcriptional regulator [Transcription]; Region: COG3905 470137005216 enoyl-CoA hydratase; Provisional; Region: PRK06688 470137005217 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 470137005218 substrate binding site [chemical binding]; other site 470137005219 oxyanion hole (OAH) forming residues; other site 470137005220 trimer interface [polypeptide binding]; other site 470137005221 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 470137005222 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 470137005223 active site 470137005224 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 470137005225 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 470137005226 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 470137005227 metal binding site [ion binding]; metal-binding site 470137005228 active site 470137005229 I-site; other site 470137005230 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 470137005231 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 470137005232 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 470137005233 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 470137005234 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878 470137005235 UbiA prenyltransferase family; Region: UbiA; pfam01040 470137005236 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 470137005237 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 470137005238 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 470137005239 chaperone protein DnaJ; Provisional; Region: PRK14299 470137005240 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 470137005241 HSP70 interaction site [polypeptide binding]; other site 470137005242 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 470137005243 dimer interface [polypeptide binding]; other site 470137005244 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 470137005245 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 470137005246 NAD binding site [chemical binding]; other site 470137005247 homotetramer interface [polypeptide binding]; other site 470137005248 homodimer interface [polypeptide binding]; other site 470137005249 substrate binding site [chemical binding]; other site 470137005250 active site 470137005251 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 470137005252 DNA-binding site [nucleotide binding]; DNA binding site 470137005253 RNA-binding motif; other site 470137005254 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 470137005255 putative acyl-acceptor binding pocket; other site 470137005256 Protein of unknown function (DUF1344); Region: DUF1344; pfam07076 470137005257 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 470137005258 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 470137005259 Tetramer interface [polypeptide binding]; other site 470137005260 active site 470137005261 FMN-binding site [chemical binding]; other site 470137005262 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 470137005263 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 470137005264 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 470137005265 dimerization interface [polypeptide binding]; other site 470137005266 active site 470137005267 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 470137005268 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 470137005269 putative active site [active] 470137005270 Zn binding site [ion binding]; other site 470137005271 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 470137005272 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 470137005273 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 470137005274 Predicted membrane protein [Function unknown]; Region: COG2261 470137005275 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3753 470137005276 Pirin-related protein [General function prediction only]; Region: COG1741 470137005277 Pirin; Region: Pirin; pfam02678 470137005278 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 470137005279 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 470137005280 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 470137005281 TPP-binding site; other site 470137005282 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 470137005283 PYR/PP interface [polypeptide binding]; other site 470137005284 dimer interface [polypeptide binding]; other site 470137005285 TPP binding site [chemical binding]; other site 470137005286 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 470137005287 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 470137005288 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 470137005289 RNA binding surface [nucleotide binding]; other site 470137005290 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 470137005291 S-adenosylmethionine binding site [chemical binding]; other site 470137005292 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 470137005293 Methyltransferase domain; Region: Methyltransf_26; pfam13659 470137005294 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 470137005295 Predicted periplasmic protein [General function prediction only]; Region: COG3895 470137005296 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 470137005297 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 470137005298 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 470137005299 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 470137005300 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 470137005301 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 470137005302 Walker A/P-loop; other site 470137005303 ATP binding site [chemical binding]; other site 470137005304 Q-loop/lid; other site 470137005305 ABC transporter signature motif; other site 470137005306 Walker B; other site 470137005307 D-loop; other site 470137005308 H-loop/switch region; other site 470137005309 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 470137005310 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 470137005311 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 470137005312 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 470137005313 classical (c) SDRs; Region: SDR_c; cd05233 470137005314 NAD(P) binding site [chemical binding]; other site 470137005315 active site 470137005316 amidophosphoribosyltransferase; Provisional; Region: PRK09123 470137005317 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 470137005318 active site 470137005319 tetramer interface [polypeptide binding]; other site 470137005320 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 470137005321 active site 470137005322 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 470137005323 Colicin V production protein; Region: Colicin_V; pfam02674 470137005324 DNA repair protein RadA; Provisional; Region: PRK11823 470137005325 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 470137005326 Walker A motif/ATP binding site; other site 470137005327 ATP binding site [chemical binding]; other site 470137005328 Walker B motif; other site 470137005329 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 470137005330 replicative DNA helicase; Provisional; Region: PRK09165 470137005331 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 470137005332 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 470137005333 Walker A motif; other site 470137005334 ATP binding site [chemical binding]; other site 470137005335 Walker B motif; other site 470137005336 DNA binding loops [nucleotide binding] 470137005337 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 470137005338 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 470137005339 S-adenosylmethionine binding site [chemical binding]; other site 470137005340 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 470137005341 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 470137005342 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 470137005343 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 470137005344 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 470137005345 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 470137005346 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 470137005347 3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936 470137005348 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 470137005349 NAD(P) binding site [chemical binding]; other site 470137005350 homotetramer interface [polypeptide binding]; other site 470137005351 homodimer interface [polypeptide binding]; other site 470137005352 active site 470137005353 acyl carrier protein; Provisional; Region: acpP; PRK00982 470137005354 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 470137005355 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 470137005356 dimer interface [polypeptide binding]; other site 470137005357 active site 470137005358 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 470137005359 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 470137005360 dimerization interface [polypeptide binding]; other site 470137005361 Uncharacterized stress-induced protein [Function unknown]; Region: COG1561 470137005362 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 470137005363 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 470137005364 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 470137005365 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 470137005366 catalytic site [active] 470137005367 G-X2-G-X-G-K; other site 470137005368 protease TldD; Provisional; Region: tldD; PRK10735 470137005369 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 470137005370 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 470137005371 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 470137005372 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 470137005373 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 470137005374 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 470137005375 Subunit I/III interface [polypeptide binding]; other site 470137005376 D-pathway; other site 470137005377 Subunit I/VIIc interface [polypeptide binding]; other site 470137005378 Subunit I/IV interface [polypeptide binding]; other site 470137005379 Subunit I/II interface [polypeptide binding]; other site 470137005380 Low-spin heme (heme a) binding site [chemical binding]; other site 470137005381 Subunit I/VIIa interface [polypeptide binding]; other site 470137005382 Subunit I/VIa interface [polypeptide binding]; other site 470137005383 Dimer interface; other site 470137005384 Putative water exit pathway; other site 470137005385 Binuclear center (heme a3/CuB) [ion binding]; other site 470137005386 K-pathway; other site 470137005387 Subunit I/Vb interface [polypeptide binding]; other site 470137005388 Putative proton exit pathway; other site 470137005389 Subunit I/VIb interface; other site 470137005390 Subunit I/VIc interface [polypeptide binding]; other site 470137005391 Electron transfer pathway; other site 470137005392 Subunit I/VIIIb interface [polypeptide binding]; other site 470137005393 Subunit I/VIIb interface [polypeptide binding]; other site 470137005394 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 470137005395 UbiA prenyltransferase family; Region: UbiA; pfam01040 470137005396 Cytochrome oxidase assembly factor [Posttranslational modification, protein turnover, chaperones]; Region: COX11; COG3175 470137005397 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 470137005398 Subunit III/VIIa interface [polypeptide binding]; other site 470137005399 Phospholipid binding site [chemical binding]; other site 470137005400 Subunit I/III interface [polypeptide binding]; other site 470137005401 Subunit III/VIb interface [polypeptide binding]; other site 470137005402 Subunit III/VIa interface; other site 470137005403 Subunit III/Vb interface [polypeptide binding]; other site 470137005404 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349 470137005405 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 470137005406 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 470137005407 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 470137005408 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 470137005409 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 470137005410 putative active site [active] 470137005411 putative substrate binding site [chemical binding]; other site 470137005412 ATP binding site [chemical binding]; other site 470137005413 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 470137005414 RNA/DNA hybrid binding site [nucleotide binding]; other site 470137005415 active site 470137005416 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 470137005417 catalytic triad [active] 470137005418 dimer interface [polypeptide binding]; other site 470137005419 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 470137005420 hypothetical protein; Validated; Region: PRK00228 470137005421 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 470137005422 PAS fold; Region: PAS_3; pfam08447 470137005423 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 470137005424 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 470137005425 metal binding site [ion binding]; metal-binding site 470137005426 active site 470137005427 I-site; other site 470137005428 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 470137005429 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 470137005430 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 470137005431 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 470137005432 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 470137005433 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 470137005434 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 470137005435 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 470137005436 pyridoxal 5'-phosphate binding site [chemical binding]; other site 470137005437 catalytic residue [active] 470137005438 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 470137005439 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 470137005440 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 470137005441 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 470137005442 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 470137005443 active site 470137005444 motif I; other site 470137005445 motif II; other site 470137005446 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 470137005447 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 470137005448 Cl- selectivity filter; other site 470137005449 Cl- binding residues [ion binding]; other site 470137005450 pore gating glutamate residue; other site 470137005451 dimer interface [polypeptide binding]; other site 470137005452 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 470137005453 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 470137005454 DNA methylase; Region: N6_N4_Mtase; pfam01555 470137005455 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 470137005456 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 470137005457 motif II; other site 470137005458 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 470137005459 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 470137005460 minor groove reading motif; other site 470137005461 helix-hairpin-helix signature motif; other site 470137005462 substrate binding pocket [chemical binding]; other site 470137005463 active site 470137005464 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 470137005465 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 470137005466 DNA binding and oxoG recognition site [nucleotide binding] 470137005467 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5389 470137005468 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 470137005469 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 470137005470 catalytic residues [active] 470137005471 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 470137005472 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 470137005473 Walker A/P-loop; other site 470137005474 ATP binding site [chemical binding]; other site 470137005475 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 470137005476 ABC transporter signature motif; other site 470137005477 Walker B; other site 470137005478 D-loop; other site 470137005479 H-loop/switch region; other site 470137005480 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 470137005481 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 470137005482 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 470137005483 pyruvate phosphate dikinase; Provisional; Region: PRK09279 470137005484 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 470137005485 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 470137005486 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 470137005487 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 470137005488 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 470137005489 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 470137005490 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 470137005491 ureidoglycolate hydrolase; Provisional; Region: PRK03606 470137005492 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 470137005493 active site 470137005494 homotetramer interface [polypeptide binding]; other site 470137005495 Protein of unknown function (DUF2793); Region: DUF2793; pfam10983 470137005496 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 470137005497 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 470137005498 NAD(P) binding site [chemical binding]; other site 470137005499 homodimer interface [polypeptide binding]; other site 470137005500 substrate binding site [chemical binding]; other site 470137005501 active site 470137005502 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 470137005503 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 470137005504 Mg++ binding site [ion binding]; other site 470137005505 putative catalytic motif [active] 470137005506 putative substrate binding site [chemical binding]; other site 470137005507 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 470137005508 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 470137005509 Homeodomain-like domain; Region: HTH_23; cl17451 470137005510 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 470137005511 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 470137005512 Integrase core domain; Region: rve; pfam00665 470137005513 Integrase core domain; Region: rve_3; pfam13683 470137005514 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 470137005515 HTH-like domain; Region: HTH_21; pfam13276 470137005516 Integrase core domain; Region: rve; pfam00665 470137005517 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 470137005518 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 470137005519 active site 470137005520 substrate binding site [chemical binding]; other site 470137005521 cosubstrate binding site; other site 470137005522 catalytic site [active] 470137005523 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 470137005524 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 470137005525 Walker A/P-loop; other site 470137005526 ATP binding site [chemical binding]; other site 470137005527 Q-loop/lid; other site 470137005528 ABC transporter signature motif; other site 470137005529 Walker B; other site 470137005530 D-loop; other site 470137005531 H-loop/switch region; other site 470137005532 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 470137005533 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 470137005534 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 470137005535 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 470137005536 inhibitor-cofactor binding pocket; inhibition site 470137005537 pyridoxal 5'-phosphate binding site [chemical binding]; other site 470137005538 catalytic residue [active] 470137005539 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 470137005540 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 470137005541 NADP-binding site; other site 470137005542 homotetramer interface [polypeptide binding]; other site 470137005543 substrate binding site [chemical binding]; other site 470137005544 homodimer interface [polypeptide binding]; other site 470137005545 active site 470137005546 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 470137005547 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 470137005548 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 470137005549 Integrase core domain; Region: rve; pfam00665 470137005550 DDE domain; Region: DDE_Tnp_IS240; pfam13610 470137005551 Integrase core domain; Region: rve_3; pfam13683 470137005552 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 470137005553 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 470137005554 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 470137005555 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 470137005556 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 470137005557 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 470137005558 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 470137005559 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 470137005560 Integrase core domain; Region: rve; pfam00665 470137005561 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 470137005562 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 470137005563 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 470137005564 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 470137005565 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 470137005566 active site 470137005567 substrate binding site [chemical binding]; other site 470137005568 metal binding site [ion binding]; metal-binding site 470137005569 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 470137005570 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 470137005571 Substrate binding site; other site 470137005572 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 470137005573 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 470137005574 dimerization interface [polypeptide binding]; other site 470137005575 putative active cleft [active] 470137005576 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 470137005577 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 470137005578 putative ADP-binding pocket [chemical binding]; other site 470137005579 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 470137005580 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 470137005581 Walker A/P-loop; other site 470137005582 ATP binding site [chemical binding]; other site 470137005583 Q-loop/lid; other site 470137005584 ABC transporter signature motif; other site 470137005585 Walker B; other site 470137005586 D-loop; other site 470137005587 H-loop/switch region; other site 470137005588 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 470137005589 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 470137005590 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 470137005591 TM-ABC transporter signature motif; other site 470137005592 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 470137005593 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_3; cd06311 470137005594 putative ligand binding site [chemical binding]; other site 470137005595 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 470137005596 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 470137005597 Metal-binding active site; metal-binding site 470137005598 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 470137005599 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 470137005600 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 470137005601 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 470137005602 xylose isomerase; Provisional; Region: PRK05474 470137005603 xylose isomerase; Region: xylose_isom_A; TIGR02630 470137005604 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 470137005605 N- and C-terminal domain interface [polypeptide binding]; other site 470137005606 D-xylulose kinase; Region: XylB; TIGR01312 470137005607 active site 470137005608 MgATP binding site [chemical binding]; other site 470137005609 catalytic site [active] 470137005610 metal binding site [ion binding]; metal-binding site 470137005611 xylulose binding site [chemical binding]; other site 470137005612 homodimer interface [polypeptide binding]; other site 470137005613 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 470137005614 DNA binding site [nucleotide binding] 470137005615 domain linker motif; other site 470137005616 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 470137005617 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 470137005618 putative ligand binding site [chemical binding]; other site 470137005619 Helix-turn-helix domain; Region: HTH_18; pfam12833 470137005620 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 470137005621 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 470137005622 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 470137005623 NAD(P) binding site [chemical binding]; other site 470137005624 catalytic residues [active] 470137005625 choline dehydrogenase; Validated; Region: PRK02106 470137005626 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 470137005627 transcriptional regulator BetI; Validated; Region: PRK00767 470137005628 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 470137005629 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 470137005630 L-asparaginase II [Amino acid transport and metabolism]; Region: AnsA; COG4448 470137005631 transcription elongation factor regulatory protein; Validated; Region: PRK06342 470137005632 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 470137005633 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 470137005634 putative addiction module antidote; Region: doc_partner; TIGR02609 470137005635 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 470137005636 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 470137005637 Cl binding site [ion binding]; other site 470137005638 oligomer interface [polypeptide binding]; other site 470137005639 Transcriptional regulators [Transcription]; Region: FadR; COG2186 470137005640 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 470137005641 DNA-binding site [nucleotide binding]; DNA binding site 470137005642 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 470137005643 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 470137005644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 470137005645 putative substrate translocation pore; other site 470137005646 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 470137005647 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 470137005648 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 470137005649 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 470137005650 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 470137005651 motif II; other site 470137005652 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 470137005653 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 470137005654 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 470137005655 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 470137005656 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 470137005657 Predicted transcriptional regulator [Transcription]; Region: COG4957 470137005658 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 470137005659 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 470137005660 DnaA box-binding interface [nucleotide binding]; other site 470137005661 amidase; Validated; Region: PRK05962 470137005662 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 470137005663 Flavin Reductases; Region: FlaRed; cl00801 470137005664 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 470137005665 putative active site [active] 470137005666 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 470137005667 heme pocket [chemical binding]; other site 470137005668 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 470137005669 dimer interface [polypeptide binding]; other site 470137005670 phosphorylation site [posttranslational modification] 470137005671 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 470137005672 ATP binding site [chemical binding]; other site 470137005673 Mg2+ binding site [ion binding]; other site 470137005674 G-X-G motif; other site 470137005675 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 470137005676 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 470137005677 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 470137005678 Uncharacterized conserved protein [Function unknown]; Region: COG5447 470137005679 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330 470137005680 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 470137005681 Predicted integral membrane protein [Function unknown]; Region: COG5436 470137005682 Uncharacterized conserved protein [Function unknown]; Region: COG5402 470137005683 Transglycosylase; Region: Transgly; pfam00912 470137005684 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 470137005685 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 470137005686 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 470137005687 Uncharacterized conserved protein [Function unknown]; Region: COG5323 470137005688 Terminase-like family; Region: Terminase_6; pfam03237 470137005689 Phage-related protein [Function unknown]; Region: COG4695 470137005690 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 470137005691 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 470137005692 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 470137005693 Phage capsid family; Region: Phage_capsid; pfam05065 470137005694 phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215 470137005695 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 470137005696 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 470137005697 oligomerization interface [polypeptide binding]; other site 470137005698 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 470137005699 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 470137005700 Predicted secreted protein [Function unknown]; Region: COG5437 470137005701 Protein of unknown function (DUF3356); Region: DUF3356; pfam11836 470137005702 Phage-related minor tail protein [Function unknown]; Region: COG5281 470137005703 Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931 470137005704 phage conserved hypothetical protein BR0599; Region: phg_TIGR02218 470137005705 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 470137005706 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 470137005707 putative phage cell wall peptidase, NlpC/P60 family; Region: phage_NlpC_fam; TIGR02219 470137005708 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 470137005709 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 470137005710 active site 470137005711 phosphorylation site [posttranslational modification] 470137005712 intermolecular recognition site; other site 470137005713 dimerization interface [polypeptide binding]; other site 470137005714 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 470137005715 DNA binding site [nucleotide binding] 470137005716 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 470137005717 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 470137005718 ATP binding site [chemical binding]; other site 470137005719 Mg2+ binding site [ion binding]; other site 470137005720 G-X-G motif; other site 470137005721 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 470137005722 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 470137005723 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 470137005724 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 470137005725 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 470137005726 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 470137005727 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 470137005728 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 470137005729 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 470137005730 protein binding site [polypeptide binding]; other site 470137005731 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 470137005732 protein binding site [polypeptide binding]; other site 470137005733 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 470137005734 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 470137005735 active site 470137005736 phosphorylation site [posttranslational modification] 470137005737 intermolecular recognition site; other site 470137005738 dimerization interface [polypeptide binding]; other site 470137005739 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 470137005740 DNA binding site [nucleotide binding] 470137005741 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 470137005742 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 470137005743 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 470137005744 dimerization interface [polypeptide binding]; other site 470137005745 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 470137005746 dimer interface [polypeptide binding]; other site 470137005747 phosphorylation site [posttranslational modification] 470137005748 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 470137005749 ATP binding site [chemical binding]; other site 470137005750 Mg2+ binding site [ion binding]; other site 470137005751 G-X-G motif; other site 470137005752 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 470137005753 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 470137005754 metal binding triad; other site 470137005755 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 470137005756 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 470137005757 metal binding triad; other site 470137005758 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 470137005759 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 470137005760 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298 470137005761 O-Antigen ligase; Region: Wzy_C; pfam04932 470137005762 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 470137005763 PAS fold; Region: PAS_3; pfam08447 470137005764 putative active site [active] 470137005765 heme pocket [chemical binding]; other site 470137005766 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 470137005767 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 470137005768 dimer interface [polypeptide binding]; other site 470137005769 phosphorylation site [posttranslational modification] 470137005770 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 470137005771 ATP binding site [chemical binding]; other site 470137005772 Mg2+ binding site [ion binding]; other site 470137005773 G-X-G motif; other site 470137005774 aminopeptidase N; Provisional; Region: pepN; PRK14015 470137005775 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 470137005776 active site 470137005777 Zn binding site [ion binding]; other site 470137005778 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 470137005779 EamA-like transporter family; Region: EamA; pfam00892 470137005780 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 470137005781 Major Facilitator Superfamily; Region: MFS_1; pfam07690 470137005782 putative substrate translocation pore; other site 470137005783 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 470137005784 Fe-S cluster binding site [ion binding]; other site 470137005785 active site 470137005786 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 470137005787 hydroxyglutarate oxidase; Provisional; Region: PRK11728 470137005788 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 470137005789 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3021 470137005790 putative catalytic site [active] 470137005791 putative metal binding site [ion binding]; other site 470137005792 putative phosphate binding site [ion binding]; other site 470137005793 AMP nucleosidase; Provisional; Region: PRK08292 470137005794 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 470137005795 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 470137005796 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 470137005797 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 470137005798 C-terminal domain interface [polypeptide binding]; other site 470137005799 GSH binding site (G-site) [chemical binding]; other site 470137005800 dimer interface [polypeptide binding]; other site 470137005801 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 470137005802 N-terminal domain interface [polypeptide binding]; other site 470137005803 putative dimer interface [polypeptide binding]; other site 470137005804 active site 470137005805 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4731 470137005806 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 470137005807 Uncharacterized conserved protein [Function unknown]; Region: COG1284 470137005808 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 470137005809 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 470137005810 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 470137005811 histidinol-phosphate aminotransferase; Provisional; Region: PRK08153 470137005812 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 470137005813 pyridoxal 5'-phosphate binding site [chemical binding]; other site 470137005814 homodimer interface [polypeptide binding]; other site 470137005815 catalytic residue [active] 470137005816 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 470137005817 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 470137005818 active site 470137005819 DNA binding site [nucleotide binding] 470137005820 Int/Topo IB signature motif; other site 470137005821 Porin subfamily; Region: Porin_2; pfam02530 470137005822 Porin subfamily; Region: Porin_2; pfam02530 470137005823 Brucella outer membrane protein 2; Region: Brucella_OMP2; pfam05244 470137005824 Uncharacterized conserved protein [Function unknown]; Region: COG3743 470137005825 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 470137005826 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 470137005827 N-acetyl-D-glucosamine binding site [chemical binding]; other site 470137005828 catalytic residue [active] 470137005829 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 470137005830 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 470137005831 dimer interface [polypeptide binding]; other site 470137005832 active site 470137005833 catalytic residue [active] 470137005834 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 470137005835 SmpB-tmRNA interface; other site 470137005836 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 470137005837 Fe-S cluster binding site [ion binding]; other site 470137005838 DNA binding site [nucleotide binding] 470137005839 active site 470137005840 Uncharacterized conserved protein [Function unknown]; Region: COG1432 470137005841 LabA_like proteins; Region: LabA; cd10911 470137005842 putative metal binding site [ion binding]; other site 470137005843 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 470137005844 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 470137005845 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 470137005846 Zn2+ binding site [ion binding]; other site 470137005847 Mg2+ binding site [ion binding]; other site 470137005848 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 470137005849 synthetase active site [active] 470137005850 NTP binding site [chemical binding]; other site 470137005851 metal binding site [ion binding]; metal-binding site 470137005852 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 470137005853 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 470137005854 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 470137005855 active site 470137005856 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 470137005857 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 470137005858 ligand binding site [chemical binding]; other site 470137005859 flexible hinge region; other site 470137005860 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 470137005861 putative switch regulator; other site 470137005862 non-specific DNA interactions [nucleotide binding]; other site 470137005863 DNA binding site [nucleotide binding] 470137005864 sequence specific DNA binding site [nucleotide binding]; other site 470137005865 putative cAMP binding site [chemical binding]; other site 470137005866 coproporphyrinogen III oxidase; Provisional; Region: PRK13347 470137005867 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 470137005868 FeS/SAM binding site; other site 470137005869 HemN C-terminal domain; Region: HemN_C; pfam06969 470137005870 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 470137005871 Major Facilitator Superfamily; Region: MFS_1; pfam07690 470137005872 putative substrate translocation pore; other site 470137005873 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 470137005874 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 470137005875 Helix-turn-helix domain; Region: HTH_18; pfam12833 470137005876 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 470137005877 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3216 470137005878 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 470137005879 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 470137005880 Catalytic site [active] 470137005881 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 470137005882 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 470137005883 ribonuclease III; Reviewed; Region: PRK12371 470137005884 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 470137005885 dimerization interface [polypeptide binding]; other site 470137005886 active site 470137005887 metal binding site [ion binding]; metal-binding site 470137005888 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 470137005889 dsRNA binding site [nucleotide binding]; other site 470137005890 Recombination protein O N terminal; Region: RecO_N; pfam11967 470137005891 DNA repair protein RecO; Region: reco; TIGR00613 470137005892 Recombination protein O C terminal; Region: RecO_C; pfam02565 470137005893 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 470137005894 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 470137005895 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 470137005896 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 470137005897 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 470137005898 dihydroorotase; Validated; Region: PRK09060 470137005899 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 470137005900 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 470137005901 active site 470137005902 TIGR02301 family protein; Region: TIGR02301 470137005903 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 470137005904 nudix motif; other site 470137005905 Uncharacterized conserved protein [Function unknown]; Region: COG2135 470137005906 Lysine efflux permease [General function prediction only]; Region: COG1279 470137005907 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 470137005908 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 470137005909 active site 470137005910 HIGH motif; other site 470137005911 nucleotide binding site [chemical binding]; other site 470137005912 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 470137005913 KMSKS motif; other site 470137005914 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 470137005915 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 470137005916 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 470137005917 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 470137005918 active site 470137005919 catalytic residues [active] 470137005920 metal binding site [ion binding]; metal-binding site 470137005921 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 470137005922 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 470137005923 Peptidase family M23; Region: Peptidase_M23; pfam01551 470137005924 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 470137005925 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 470137005926 S-adenosylmethionine binding site [chemical binding]; other site 470137005927 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312 470137005928 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 470137005929 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 470137005930 SurA N-terminal domain; Region: SurA_N; pfam09312 470137005931 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 470137005932 OstA-like protein; Region: OstA; cl00844 470137005933 Organic solvent tolerance protein; Region: OstA_C; pfam04453 470137005934 Predicted permeases [General function prediction only]; Region: COG0795 470137005935 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 470137005936 Predicted permeases [General function prediction only]; Region: COG0795 470137005937 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 470137005938 multifunctional aminopeptidase A; Provisional; Region: PRK00913 470137005939 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 470137005940 interface (dimer of trimers) [polypeptide binding]; other site 470137005941 Substrate-binding/catalytic site; other site 470137005942 Zn-binding sites [ion binding]; other site 470137005943 DNA polymerase III subunit chi; Validated; Region: PRK05728 470137005944 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 470137005945 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 470137005946 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 470137005947 Walker A/P-loop; other site 470137005948 ATP binding site [chemical binding]; other site 470137005949 ABC transporter signature motif; other site 470137005950 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 470137005951 Walker B; other site 470137005952 D-loop; other site 470137005953 ABC transporter; Region: ABC_tran_2; pfam12848 470137005954 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 470137005955 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 470137005956 DinB superfamily; Region: DinB_2; pfam12867 470137005957 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 470137005958 active site 470137005959 multimer interface [polypeptide binding]; other site 470137005960 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 470137005961 Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187 470137005962 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 470137005963 MoaE homodimer interface [polypeptide binding]; other site 470137005964 MoaD interaction [polypeptide binding]; other site 470137005965 active site residues [active] 470137005966 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 470137005967 MoaE interaction surface [polypeptide binding]; other site 470137005968 MoeB interaction surface [polypeptide binding]; other site 470137005969 thiocarboxylated glycine; other site 470137005970 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 470137005971 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 470137005972 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 470137005973 GIY-YIG motif/motif A; other site 470137005974 active site 470137005975 catalytic site [active] 470137005976 putative DNA binding site [nucleotide binding]; other site 470137005977 metal binding site [ion binding]; metal-binding site 470137005978 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 470137005979 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 470137005980 short chain dehydrogenase; Provisional; Region: PRK09134 470137005981 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 470137005982 NAD(P) binding site [chemical binding]; other site 470137005983 active site 470137005984 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 470137005985 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 470137005986 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 470137005987 putative C-terminal domain interface [polypeptide binding]; other site 470137005988 putative GSH binding site (G-site) [chemical binding]; other site 470137005989 putative dimer interface [polypeptide binding]; other site 470137005990 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 470137005991 dimer interface [polypeptide binding]; other site 470137005992 N-terminal domain interface [polypeptide binding]; other site 470137005993 putative substrate binding pocket (H-site) [chemical binding]; other site 470137005994 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 470137005995 B1 nucleotide binding pocket [chemical binding]; other site 470137005996 B2 nucleotide binding pocket [chemical binding]; other site 470137005997 CAS motifs; other site 470137005998 active site 470137005999 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 470137006000 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 470137006001 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 470137006002 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 470137006003 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 470137006004 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 470137006005 putative [4Fe-4S] binding site [ion binding]; other site 470137006006 putative molybdopterin cofactor binding site [chemical binding]; other site 470137006007 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 470137006008 putative molybdopterin cofactor binding site; other site 470137006009 Protein of unknown function (DUF992); Region: DUF992; pfam06186 470137006010 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 470137006011 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 470137006012 active site 470137006013 substrate binding site [chemical binding]; other site 470137006014 cosubstrate binding site; other site 470137006015 catalytic site [active] 470137006016 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 470137006017 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 470137006018 dimerization interface [polypeptide binding]; other site 470137006019 putative ATP binding site [chemical binding]; other site 470137006020 Domain of unknown function DUF20; Region: UPF0118; pfam01594 470137006021 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 470137006022 hypothetical protein; Validated; Region: PRK09087 470137006023 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 470137006024 Walker A motif; other site 470137006025 ATP binding site [chemical binding]; other site 470137006026 Walker B motif; other site 470137006027 arginine finger; other site 470137006028 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 470137006029 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 470137006030 NAD(P) binding site [chemical binding]; other site 470137006031 active site 470137006032 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 470137006033 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 470137006034 putative NAD(P) binding site [chemical binding]; other site 470137006035 putative active site [active] 470137006036 L-lactate permease; Region: Lactate_perm; cl00701 470137006037 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 470137006038 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 470137006039 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 470137006040 active site 470137006041 catalytic site [active] 470137006042 substrate binding site [chemical binding]; other site 470137006043 Archaeal adenylate kinase [Nucleotide transport and metabolism]; Region: AdkA; COG2019 470137006044 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 470137006045 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 470137006046 non-specific DNA binding site [nucleotide binding]; other site 470137006047 salt bridge; other site 470137006048 sequence-specific DNA binding site [nucleotide binding]; other site 470137006049 Uncharacterized conserved protein [Function unknown]; Region: COG4933 470137006050 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 470137006051 Integrase core domain; Region: rve; pfam00665 470137006052 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 470137006053 AAA domain; Region: AAA_22; pfam13401 470137006054 AAA ATPase domain; Region: AAA_16; pfam13191 470137006055 Domain of unknown function (DUF955); Region: DUF955; pfam06114 470137006056 Uncharacterized protein containing a TIR (Toll-Interleukin 1-resistance) domain [Function unknown]; Region: COG4916 470137006057 TIR domain; Region: TIR_2; pfam13676 470137006058 Bacterial SH3 domain; Region: SH3_3; pfam08239 470137006059 cystathionine beta-lyase; Provisional; Region: PRK05967 470137006060 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 470137006061 homodimer interface [polypeptide binding]; other site 470137006062 substrate-cofactor binding pocket; other site 470137006063 pyridoxal 5'-phosphate binding site [chemical binding]; other site 470137006064 catalytic residue [active] 470137006065 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 470137006066 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 470137006067 active site 470137006068 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 470137006069 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 470137006070 substrate binding pocket [chemical binding]; other site 470137006071 membrane-bound complex binding site; other site 470137006072 hinge residues; other site 470137006073 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 470137006074 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137006075 conserved gate region; other site 470137006076 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137006077 putative PBP binding loops; other site 470137006078 dimer interface [polypeptide binding]; other site 470137006079 ABC-ATPase subunit interface; other site 470137006080 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 470137006081 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137006082 dimer interface [polypeptide binding]; other site 470137006083 conserved gate region; other site 470137006084 putative PBP binding loops; other site 470137006085 ABC-ATPase subunit interface; other site 470137006086 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 470137006087 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 470137006088 Walker A/P-loop; other site 470137006089 ATP binding site [chemical binding]; other site 470137006090 Q-loop/lid; other site 470137006091 ABC transporter signature motif; other site 470137006092 Walker B; other site 470137006093 D-loop; other site 470137006094 H-loop/switch region; other site 470137006095 salicylate hydroxylase; Provisional; Region: PRK06475 470137006096 salicylate hydroxylase; Provisional; Region: PRK08163 470137006097 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391 470137006098 polyphosphate kinase; Provisional; Region: PRK05443 470137006099 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 470137006100 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 470137006101 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 470137006102 putative domain interface [polypeptide binding]; other site 470137006103 putative active site [active] 470137006104 catalytic site [active] 470137006105 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 470137006106 putative domain interface [polypeptide binding]; other site 470137006107 putative active site [active] 470137006108 catalytic site [active] 470137006109 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 470137006110 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 470137006111 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 470137006112 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 470137006113 catalytic site [active] 470137006114 putative active site [active] 470137006115 putative substrate binding site [chemical binding]; other site 470137006116 HRDC domain; Region: HRDC; pfam00570 470137006117 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 470137006118 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 470137006119 dimer interface [polypeptide binding]; other site 470137006120 anticodon binding site; other site 470137006121 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 470137006122 homodimer interface [polypeptide binding]; other site 470137006123 motif 1; other site 470137006124 active site 470137006125 motif 2; other site 470137006126 GAD domain; Region: GAD; pfam02938 470137006127 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 470137006128 active site 470137006129 motif 3; other site 470137006130 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 470137006131 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 470137006132 CAP-like domain; other site 470137006133 active site 470137006134 primary dimer interface [polypeptide binding]; other site 470137006135 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 470137006136 Putative arginyl-tRNA:protein arginylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG2935 470137006137 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 470137006138 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 470137006139 Predicted membrane protein/domain [Function unknown]; Region: COG1714 470137006140 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 470137006141 dimer interface [polypeptide binding]; other site 470137006142 allosteric magnesium binding site [ion binding]; other site 470137006143 active site 470137006144 aspartate-rich active site metal binding site; other site 470137006145 Schiff base residues; other site 470137006146 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 470137006147 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 470137006148 substrate binding site [chemical binding]; other site 470137006149 oxyanion hole (OAH) forming residues; other site 470137006150 trimer interface [polypeptide binding]; other site 470137006151 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 470137006152 Transcriptional regulators [Transcription]; Region: MarR; COG1846 470137006153 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 470137006154 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 470137006155 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 470137006156 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 470137006157 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 470137006158 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 470137006159 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 470137006160 dimer interface [polypeptide binding]; other site 470137006161 active site 470137006162 glycine-pyridoxal phosphate binding site [chemical binding]; other site 470137006163 folate binding site [chemical binding]; other site 470137006164 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 470137006165 ATP cone domain; Region: ATP-cone; pfam03477 470137006166 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 470137006167 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 470137006168 catalytic motif [active] 470137006169 Zn binding site [ion binding]; other site 470137006170 RibD C-terminal domain; Region: RibD_C; cl17279 470137006171 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 470137006172 Lumazine binding domain; Region: Lum_binding; pfam00677 470137006173 Lumazine binding domain; Region: Lum_binding; pfam00677 470137006174 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 470137006175 homopentamer interface [polypeptide binding]; other site 470137006176 active site 470137006177 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 470137006178 putative RNA binding site [nucleotide binding]; other site 470137006179 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; COG3808 470137006180 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 470137006181 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 470137006182 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 470137006183 Uncharacterized conserved protein [Function unknown]; Region: COG5452 470137006184 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 470137006185 putative phosphate acyltransferase; Provisional; Region: PRK05331 470137006186 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 470137006187 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 470137006188 dimer interface [polypeptide binding]; other site 470137006189 active site 470137006190 CoA binding pocket [chemical binding]; other site 470137006191 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 470137006192 IHF dimer interface [polypeptide binding]; other site 470137006193 IHF - DNA interface [nucleotide binding]; other site 470137006194 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 470137006195 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 470137006196 DNA binding residues [nucleotide binding] 470137006197 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 470137006198 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 470137006199 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 470137006200 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 470137006201 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 470137006202 SLBB domain; Region: SLBB; pfam10531 470137006203 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 470137006204 Protein of unknown function (DUF2842); Region: DUF2842; pfam11003 470137006205 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 470137006206 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 470137006207 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 470137006208 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 470137006209 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 470137006210 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 470137006211 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 470137006212 oligomer interface [polypeptide binding]; other site 470137006213 putative active site [active] 470137006214 Mn binding site [ion binding]; other site 470137006215 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 470137006216 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 470137006217 23S rRNA interface [nucleotide binding]; other site 470137006218 L3 interface [polypeptide binding]; other site 470137006219 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 470137006220 CoenzymeA binding site [chemical binding]; other site 470137006221 subunit interaction site [polypeptide binding]; other site 470137006222 PHB binding site; other site 470137006223 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994 470137006224 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 470137006225 homodimer interface [polypeptide binding]; other site 470137006226 substrate-cofactor binding pocket; other site 470137006227 pyridoxal 5'-phosphate binding site [chemical binding]; other site 470137006228 catalytic residue [active] 470137006229 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 470137006230 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 470137006231 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 470137006232 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 470137006233 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 470137006234 NADH dehydrogenase subunit D; Validated; Region: PRK06075 470137006235 NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905 470137006236 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 470137006237 putative dimer interface [polypeptide binding]; other site 470137006238 [2Fe-2S] cluster binding site [ion binding]; other site 470137006239 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 470137006240 SLBB domain; Region: SLBB; pfam10531 470137006241 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 470137006242 NADH dehydrogenase subunit G; Validated; Region: PRK09130 470137006243 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 470137006244 catalytic loop [active] 470137006245 iron binding site [ion binding]; other site 470137006246 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 470137006247 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 470137006248 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 470137006249 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 470137006250 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 470137006251 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 470137006252 4Fe-4S binding domain; Region: Fer4; pfam00037 470137006253 4Fe-4S binding domain; Region: Fer4; pfam00037 470137006254 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 470137006255 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 470137006256 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 470137006257 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 470137006258 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 470137006259 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 470137006260 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 470137006261 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 470137006262 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 470137006263 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 470137006264 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 470137006265 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 470137006266 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 470137006267 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 470137006268 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 470137006269 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 470137006270 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 470137006271 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 470137006272 dimer interface [polypeptide binding]; other site 470137006273 substrate binding site [chemical binding]; other site 470137006274 metal binding site [ion binding]; metal-binding site 470137006275 Predicted secreted protein [Function unknown]; Region: COG5454 470137006276 prolyl-tRNA synthetase; Provisional; Region: PRK12325 470137006277 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 470137006278 dimer interface [polypeptide binding]; other site 470137006279 motif 1; other site 470137006280 active site 470137006281 motif 2; other site 470137006282 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 470137006283 active site 470137006284 motif 3; other site 470137006285 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 470137006286 anticodon binding site; other site 470137006287 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 470137006288 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 470137006289 FtsX-like permease family; Region: FtsX; pfam02687 470137006290 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 470137006291 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 470137006292 Walker A/P-loop; other site 470137006293 ATP binding site [chemical binding]; other site 470137006294 Q-loop/lid; other site 470137006295 ABC transporter signature motif; other site 470137006296 Walker B; other site 470137006297 D-loop; other site 470137006298 H-loop/switch region; other site 470137006299 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 470137006300 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 470137006301 putative active site [active] 470137006302 putative PHP Thumb interface [polypeptide binding]; other site 470137006303 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 470137006304 generic binding surface II; other site 470137006305 generic binding surface I; other site 470137006306 Protein of unknwon function (DUF3008); Region: DUF3008; pfam11450 470137006307 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 470137006308 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 470137006309 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 470137006310 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 470137006311 RNA binding surface [nucleotide binding]; other site 470137006312 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 470137006313 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 470137006314 Ligand Binding Site [chemical binding]; other site 470137006315 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 470137006316 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 470137006317 active site 470137006318 putative lithium-binding site [ion binding]; other site 470137006319 substrate binding site [chemical binding]; other site 470137006320 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 470137006321 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 470137006322 putative substrate translocation pore; other site 470137006323 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 470137006324 putative GSH binding site [chemical binding]; other site 470137006325 catalytic residues [active] 470137006326 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 470137006327 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 470137006328 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 470137006329 dimerization interface [polypeptide binding]; other site 470137006330 ATP binding site [chemical binding]; other site 470137006331 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 470137006332 dimerization interface [polypeptide binding]; other site 470137006333 ATP binding site [chemical binding]; other site 470137006334 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 470137006335 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 470137006336 C-terminal domain interface [polypeptide binding]; other site 470137006337 GSH binding site (G-site) [chemical binding]; other site 470137006338 dimer interface [polypeptide binding]; other site 470137006339 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 470137006340 N-terminal domain interface [polypeptide binding]; other site 470137006341 dimer interface [polypeptide binding]; other site 470137006342 substrate binding pocket (H-site) [chemical binding]; other site 470137006343 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 470137006344 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 470137006345 putative active site [active] 470137006346 catalytic triad [active] 470137006347 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 470137006348 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 470137006349 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 470137006350 ATP binding site [chemical binding]; other site 470137006351 active site 470137006352 substrate binding site [chemical binding]; other site 470137006353 Uncharacterized conserved protein [Function unknown]; Region: COG5467 470137006354 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 470137006355 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 470137006356 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 470137006357 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 470137006358 putative metal binding site [ion binding]; other site 470137006359 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 470137006360 active site 470137006361 adenylosuccinate lyase; Provisional; Region: PRK07492 470137006362 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 470137006363 tetramer interface [polypeptide binding]; other site 470137006364 active site 470137006365 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 470137006366 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 470137006367 substrate binding site [chemical binding]; other site 470137006368 hexamer interface [polypeptide binding]; other site 470137006369 metal binding site [ion binding]; metal-binding site 470137006370 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 470137006371 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 470137006372 putative acyl-acceptor binding pocket; other site 470137006373 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 470137006374 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266 470137006375 putative NAD(P) binding site [chemical binding]; other site 470137006376 structural Zn binding site [ion binding]; other site 470137006377 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501 470137006378 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 470137006379 dimer interface [polypeptide binding]; other site 470137006380 active site 470137006381 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519 470137006382 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 470137006383 active site 470137006384 acyl carrier protein; Provisional; Region: PRK06508 470137006385 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 470137006386 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 470137006387 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 470137006388 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 470137006389 active site 470137006390 catalytic residues [active] 470137006391 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 470137006392 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 470137006393 substrate binding site [chemical binding]; other site 470137006394 ATP binding site [chemical binding]; other site 470137006395 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 470137006396 Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454 470137006397 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 470137006398 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 470137006399 active site 470137006400 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 470137006401 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 470137006402 active site 470137006403 motif I; other site 470137006404 motif II; other site 470137006405 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 470137006406 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 470137006407 substrate binding pocket [chemical binding]; other site 470137006408 membrane-bound complex binding site; other site 470137006409 hinge residues; other site 470137006410 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 470137006411 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 470137006412 FMN binding site [chemical binding]; other site 470137006413 active site 470137006414 catalytic residues [active] 470137006415 substrate binding site [chemical binding]; other site 470137006416 Predicted aspartyl protease [General function prediction only]; Region: COG3577 470137006417 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 470137006418 catalytic motif [active] 470137006419 Catalytic residue [active] 470137006420 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 470137006421 cobalamin synthase; Reviewed; Region: cobS; PRK00235 470137006422 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 470137006423 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 470137006424 putative dimer interface [polypeptide binding]; other site 470137006425 active site pocket [active] 470137006426 putative cataytic base [active] 470137006427 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 470137006428 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 470137006429 putative DNA binding site [nucleotide binding]; other site 470137006430 putative Zn2+ binding site [ion binding]; other site 470137006431 AsnC family; Region: AsnC_trans_reg; pfam01037 470137006432 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 470137006433 putative uracil binding site [chemical binding]; other site 470137006434 putative active site [active] 470137006435 Staphylococcal nuclease homologues; Region: SNc; smart00318 470137006436 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 470137006437 Catalytic site; other site 470137006438 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 470137006439 Sel1-like repeats; Region: SEL1; smart00671 470137006440 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 470137006441 putative catalytic site [active] 470137006442 putative phosphate binding site [ion binding]; other site 470137006443 active site 470137006444 metal binding site A [ion binding]; metal-binding site 470137006445 DNA binding site [nucleotide binding] 470137006446 putative AP binding site [nucleotide binding]; other site 470137006447 putative metal binding site B [ion binding]; other site 470137006448 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 470137006449 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 470137006450 putative metal binding site [ion binding]; other site 470137006451 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 470137006452 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 470137006453 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 470137006454 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 470137006455 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 470137006456 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 470137006457 active site 470137006458 HIGH motif; other site 470137006459 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 470137006460 KMSK motif region; other site 470137006461 tRNA binding surface [nucleotide binding]; other site 470137006462 DALR anticodon binding domain; Region: DALR_1; smart00836 470137006463 anticodon binding site; other site 470137006464 Sporulation related domain; Region: SPOR; pfam05036 470137006465 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 470137006466 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 470137006467 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 470137006468 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 470137006469 twin arginine translocase protein A; Provisional; Region: tatA; PRK00720 470137006470 sec-independent translocase; Provisional; Region: PRK00708 470137006471 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 470137006472 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 470137006473 seryl-tRNA synthetase; Provisional; Region: PRK05431 470137006474 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 470137006475 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 470137006476 dimer interface [polypeptide binding]; other site 470137006477 active site 470137006478 motif 1; other site 470137006479 motif 2; other site 470137006480 motif 3; other site 470137006481 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 470137006482 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 470137006483 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 470137006484 S-adenosylmethionine binding site [chemical binding]; other site 470137006485 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 470137006486 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 470137006487 Peptidase family M23; Region: Peptidase_M23; pfam01551 470137006488 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 470137006489 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 470137006490 Walker A motif; other site 470137006491 ATP binding site [chemical binding]; other site 470137006492 Walker B motif; other site 470137006493 Preprotein translocase subunit YajC [Intracellular trafficking and secretion]; Region: YajC; COG1862 470137006494 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13023 470137006495 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 470137006496 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 470137006497 Protein export membrane protein; Region: SecD_SecF; pfam02355 470137006498 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 470137006499 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 470137006500 substrate binding pocket [chemical binding]; other site 470137006501 substrate-Mg2+ binding site; other site 470137006502 aspartate-rich region 1; other site 470137006503 aspartate-rich region 2; other site 470137006504 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 470137006505 Glucose inhibited division protein A; Region: GIDA; pfam01134 470137006506 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 470137006507 Predicted membrane protein [Function unknown]; Region: COG4872 470137006508 Uncharacterized membrane-anchored protein [Function unknown]; Region: COG4929 470137006509 trigger factor; Provisional; Region: tig; PRK01490 470137006510 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 470137006511 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 470137006512 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 470137006513 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 470137006514 GatB domain; Region: GatB_Yqey; smart00845 470137006515 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 470137006516 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 470137006517 NADH dehydrogenase; Validated; Region: PRK08183 470137006518 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4765 470137006519 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 470137006520 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 470137006521 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 470137006522 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 470137006523 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 470137006524 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 470137006525 carboxyltransferase (CT) interaction site; other site 470137006526 biotinylation site [posttranslational modification]; other site 470137006527 Dehydroquinase class II; Region: DHquinase_II; pfam01220 470137006528 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 470137006529 trimer interface [polypeptide binding]; other site 470137006530 active site 470137006531 dimer interface [polypeptide binding]; other site 470137006532 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 470137006533 Peptidase family M48; Region: Peptidase_M48; cl12018 470137006534 aspartate aminotransferase; Provisional; Region: PRK05764 470137006535 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 470137006536 pyridoxal 5'-phosphate binding site [chemical binding]; other site 470137006537 homodimer interface [polypeptide binding]; other site 470137006538 catalytic residue [active] 470137006539 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 470137006540 RNA binding site [nucleotide binding]; other site 470137006541 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 470137006542 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 470137006543 AMIN domain; Region: AMIN; pfam11741 470137006544 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 470137006545 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 470137006546 active site 470137006547 metal binding site [ion binding]; metal-binding site 470137006548 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 470137006549 Transglycosylase; Region: Transgly; pfam00912 470137006550 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 470137006551 peptide chain release factor 2; Provisional; Region: PRK07342 470137006552 This domain is found in peptide chain release factors; Region: PCRF; smart00937 470137006553 RF-1 domain; Region: RF-1; pfam00472 470137006554 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 470137006555 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 470137006556 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 470137006557 dinuclear metal binding motif [ion binding]; other site 470137006558 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 470137006559 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 470137006560 catalytic triad [active] 470137006561 AsmA family; Region: AsmA; pfam05170 470137006562 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 470137006563 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 470137006564 active site 470137006565 HIGH motif; other site 470137006566 dimer interface [polypeptide binding]; other site 470137006567 KMSKS motif; other site 470137006568 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 470137006569 RNA binding surface [nucleotide binding]; other site 470137006570 Predicted molecular chaperone distantly related to HSP70-fold metalloproteases [Posttranslational modification, protein turnover, chaperones]; Region: COG2377 470137006571 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 470137006572 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 470137006573 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 470137006574 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 470137006575 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 470137006576 catalytic residue [active] 470137006577 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 470137006578 putative ABC transporter; Region: ycf24; CHL00085 470137006579 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 470137006580 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 470137006581 Walker A/P-loop; other site 470137006582 ATP binding site [chemical binding]; other site 470137006583 Q-loop/lid; other site 470137006584 ABC transporter signature motif; other site 470137006585 Walker B; other site 470137006586 D-loop; other site 470137006587 H-loop/switch region; other site 470137006588 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 470137006589 FeS assembly protein SufD; Region: sufD; TIGR01981 470137006590 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 470137006591 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 470137006592 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 470137006593 catalytic residue [active] 470137006594 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 470137006595 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 470137006596 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 470137006597 active site 470137006598 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 470137006599 ATP-NAD kinase; Region: NAD_kinase; pfam01513 470137006600 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 470137006601 helicase 45; Provisional; Region: PTZ00424 470137006602 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 470137006603 ATP binding site [chemical binding]; other site 470137006604 Mg++ binding site [ion binding]; other site 470137006605 motif III; other site 470137006606 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 470137006607 nucleotide binding region [chemical binding]; other site 470137006608 ATP-binding site [chemical binding]; other site 470137006609 FeS assembly scaffold SufA; Region: sufA_proteo; TIGR01997 470137006610 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 470137006611 metal-binding site [ion binding] 470137006612 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 470137006613 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 470137006614 S-adenosylmethionine binding site [chemical binding]; other site 470137006615 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 470137006616 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3827 470137006617 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 470137006618 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 470137006619 HIGH motif; other site 470137006620 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 470137006621 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 470137006622 active site 470137006623 KMSKS motif; other site 470137006624 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 470137006625 tRNA binding surface [nucleotide binding]; other site 470137006626 anticodon binding site; other site 470137006627 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 470137006628 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 470137006629 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 470137006630 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 470137006631 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 470137006632 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 470137006633 putative C-terminal domain interface [polypeptide binding]; other site 470137006634 putative GSH binding site (G-site) [chemical binding]; other site 470137006635 putative dimer interface [polypeptide binding]; other site 470137006636 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 470137006637 putative N-terminal domain interface [polypeptide binding]; other site 470137006638 putative dimer interface [polypeptide binding]; other site 470137006639 putative substrate binding pocket (H-site) [chemical binding]; other site 470137006640 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 470137006641 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137006642 dimer interface [polypeptide binding]; other site 470137006643 conserved gate region; other site 470137006644 putative PBP binding loops; other site 470137006645 ABC-ATPase subunit interface; other site 470137006646 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 470137006647 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137006648 dimer interface [polypeptide binding]; other site 470137006649 conserved gate region; other site 470137006650 putative PBP binding loops; other site 470137006651 ABC-ATPase subunit interface; other site 470137006652 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 470137006653 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 470137006654 substrate binding pocket [chemical binding]; other site 470137006655 membrane-bound complex binding site; other site 470137006656 hinge residues; other site 470137006657 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 470137006658 Walker A motif; other site 470137006659 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 470137006660 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 470137006661 GTP binding site; other site 470137006662 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 470137006663 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 470137006664 FeS/SAM binding site; other site 470137006665 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 470137006666 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 470137006667 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 470137006668 hypothetical protein; Provisional; Region: PRK06753 470137006669 fumarate hydratase; Provisional; Region: PRK15389 470137006670 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 470137006671 Fumarase C-terminus; Region: Fumerase_C; pfam05683 470137006672 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 470137006673 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 470137006674 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 470137006675 Transglycosylase associated protein; Region: Transgly_assoc; pfam04226 470137006676 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 470137006677 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 470137006678 active site 470137006679 Int/Topo IB signature motif; other site 470137006680 catalytic residues [active] 470137006681 DNA binding site [nucleotide binding] 470137006682 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 470137006683 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 470137006684 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 470137006685 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929 470137006686 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 470137006687 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 470137006688 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 470137006689 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 470137006690 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 470137006691 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 470137006692 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 470137006693 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 470137006694 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 470137006695 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 470137006696 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 470137006697 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 470137006698 ArsC family; Region: ArsC; pfam03960 470137006699 catalytic residues [active] 470137006700 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 470137006701 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 470137006702 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 470137006703 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 470137006704 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 470137006705 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 470137006706 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 470137006707 TMP-binding site; other site 470137006708 ATP-binding site [chemical binding]; other site 470137006709 DNA polymerase III subunit delta'; Validated; Region: PRK09112 470137006710 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 470137006711 DNA polymerase III subunit delta'; Validated; Region: PRK08485 470137006712 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 470137006713 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 470137006714 active site 470137006715 HIGH motif; other site 470137006716 KMSKS motif; other site 470137006717 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 470137006718 tRNA binding surface [nucleotide binding]; other site 470137006719 anticodon binding site; other site 470137006720 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 470137006721 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 470137006722 active site 470137006723 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 470137006724 putative hydrolase; Provisional; Region: PRK02113 470137006725 cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657 470137006726 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 470137006727 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 470137006728 Walker A/P-loop; other site 470137006729 ATP binding site [chemical binding]; other site 470137006730 Q-loop/lid; other site 470137006731 ABC transporter signature motif; other site 470137006732 Walker B; other site 470137006733 D-loop; other site 470137006734 H-loop/switch region; other site 470137006735 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 470137006736 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 470137006737 active site 470137006738 EamA-like transporter family; Region: EamA; pfam00892 470137006739 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 470137006740 EamA-like transporter family; Region: EamA; pfam00892 470137006741 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 470137006742 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 470137006743 motif I; other site 470137006744 active site 470137006745 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 470137006746 motif II; other site 470137006747 Chaperone required for the assembly of the mitochondrial F1-ATPase [Posttranslational modification, protein turnover, chaperones]; Region: COG5387 470137006748 glutamine synthetase; Provisional; Region: glnA; PRK09469 470137006749 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 470137006750 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 470137006751 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 470137006752 Nitrogen regulatory protein P-II; Region: P-II; smart00938 470137006753 Uncharacterized conserved protein [Function unknown]; Region: COG0062 470137006754 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 470137006755 putative substrate binding site [chemical binding]; other site 470137006756 putative ATP binding site [chemical binding]; other site 470137006757 phosphoglycolate phosphatase; Provisional; Region: PRK13222 470137006758 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 470137006759 motif II; other site 470137006760 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 470137006761 tetramer (dimer of dimers) interface [polypeptide binding]; other site 470137006762 active site 470137006763 dimer interface [polypeptide binding]; other site 470137006764 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3184 470137006765 glutathione reductase; Validated; Region: PRK06116 470137006766 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 470137006767 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 470137006768 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 470137006769 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 470137006770 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 470137006771 NAD synthetase; Provisional; Region: PRK13981 470137006772 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 470137006773 multimer interface [polypeptide binding]; other site 470137006774 active site 470137006775 catalytic triad [active] 470137006776 protein interface 1 [polypeptide binding]; other site 470137006777 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 470137006778 homodimer interface [polypeptide binding]; other site 470137006779 NAD binding pocket [chemical binding]; other site 470137006780 ATP binding pocket [chemical binding]; other site 470137006781 Mg binding site [ion binding]; other site 470137006782 active-site loop [active] 470137006783 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 470137006784 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 470137006785 active site 470137006786 HIGH motif; other site 470137006787 nucleotide binding site [chemical binding]; other site 470137006788 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 470137006789 active site 470137006790 KMSKS motif; other site 470137006791 malic enzyme; Reviewed; Region: PRK12862 470137006792 Malic enzyme, N-terminal domain; Region: malic; pfam00390 470137006793 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 470137006794 putative NAD(P) binding site [chemical binding]; other site 470137006795 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 470137006796 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 470137006797 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 470137006798 active site 470137006799 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 470137006800 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 470137006801 Permease; Region: Permease; pfam02405 470137006802 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 470137006803 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 470137006804 Walker A/P-loop; other site 470137006805 ATP binding site [chemical binding]; other site 470137006806 Q-loop/lid; other site 470137006807 ABC transporter signature motif; other site 470137006808 Walker B; other site 470137006809 D-loop; other site 470137006810 H-loop/switch region; other site 470137006811 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 470137006812 mce related protein; Region: MCE; pfam02470 470137006813 ABC-type uncharacterized transport system, auxiliary component [General function prediction only]; Region: COG3218 470137006814 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 470137006815 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 470137006816 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 470137006817 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 470137006818 catalytic loop [active] 470137006819 iron binding site [ion binding]; other site 470137006820 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 470137006821 Predicted secreted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5661 470137006822 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 470137006823 dihydropteroate synthase; Region: DHPS; TIGR01496 470137006824 substrate binding pocket [chemical binding]; other site 470137006825 dimer interface [polypeptide binding]; other site 470137006826 inhibitor binding site; inhibition site 470137006827 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 470137006828 homooctamer interface [polypeptide binding]; other site 470137006829 active site 470137006830 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 470137006831 catalytic center binding site [active] 470137006832 ATP binding site [chemical binding]; other site 470137006833 Predicted membrane protein [Function unknown]; Region: COG3768 470137006834 Domain of unknown function (DUF697); Region: DUF697; cl12064 470137006835 Predicted ATPase [General function prediction only]; Region: COG3106 470137006836 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 470137006837 catalytic core [active] 470137006838 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 470137006839 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 470137006840 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 470137006841 PAS domain; Region: PAS_9; pfam13426 470137006842 putative active site [active] 470137006843 heme pocket [chemical binding]; other site 470137006844 PAS fold; Region: PAS_4; pfam08448 470137006845 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 470137006846 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 470137006847 dimer interface [polypeptide binding]; other site 470137006848 phosphorylation site [posttranslational modification] 470137006849 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 470137006850 ATP binding site [chemical binding]; other site 470137006851 Mg2+ binding site [ion binding]; other site 470137006852 G-X-G motif; other site 470137006853 Response regulator receiver domain; Region: Response_reg; pfam00072 470137006854 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 470137006855 active site 470137006856 phosphorylation site [posttranslational modification] 470137006857 intermolecular recognition site; other site 470137006858 dimerization interface [polypeptide binding]; other site 470137006859 Predicted flavoproteins [General function prediction only]; Region: COG2081 470137006860 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 470137006861 Beta-lactamase; Region: Beta-lactamase; pfam00144 470137006862 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 470137006863 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 470137006864 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 470137006865 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 470137006866 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 470137006867 active site 470137006868 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 470137006869 TSCPD domain; Region: TSCPD; pfam12637 470137006870 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 470137006871 nudix motif; other site 470137006872 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 470137006873 active site 470137006874 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 470137006875 Ligand Binding Site [chemical binding]; other site 470137006876 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 470137006877 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 470137006878 putative MPT binding site; other site 470137006879 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 470137006880 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 470137006881 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 470137006882 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 470137006883 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 470137006884 putative Ile/Val binding site [chemical binding]; other site 470137006885 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 470137006886 DEAD-like helicases superfamily; Region: DEXDc; smart00487 470137006887 ATP binding site [chemical binding]; other site 470137006888 Mg++ binding site [ion binding]; other site 470137006889 motif III; other site 470137006890 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 470137006891 nucleotide binding region [chemical binding]; other site 470137006892 ATP-binding site [chemical binding]; other site 470137006893 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 470137006894 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 470137006895 dimer interface [polypeptide binding]; other site 470137006896 pyridoxal 5'-phosphate binding site [chemical binding]; other site 470137006897 catalytic residue [active] 470137006898 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 470137006899 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 470137006900 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 470137006901 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 470137006902 active site residue [active] 470137006903 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 470137006904 active site residue [active] 470137006905 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 470137006906 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 470137006907 Coenzyme A binding pocket [chemical binding]; other site 470137006908 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 470137006909 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 470137006910 metal binding site [ion binding]; metal-binding site 470137006911 active site 470137006912 I-site; other site 470137006913 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 470137006914 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 470137006915 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 470137006916 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 470137006917 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 470137006918 putative substrate translocation pore; other site 470137006919 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 470137006920 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 470137006921 HlyD family secretion protein; Region: HlyD_3; pfam13437 470137006922 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 470137006923 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 470137006924 putative NAD(P) binding site [chemical binding]; other site 470137006925 putative substrate binding site [chemical binding]; other site 470137006926 catalytic Zn binding site [ion binding]; other site 470137006927 structural Zn binding site [ion binding]; other site 470137006928 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 470137006929 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 470137006930 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 470137006931 active site 470137006932 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 470137006933 Tetratricopeptide repeat; Region: TPR_1; pfam00515 470137006934 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 470137006935 S-adenosylmethionine binding site [chemical binding]; other site 470137006936 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 470137006937 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 470137006938 UDP-glucose 4-epimerase; Region: PLN02240 470137006939 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 470137006940 NAD binding site [chemical binding]; other site 470137006941 homodimer interface [polypeptide binding]; other site 470137006942 active site 470137006943 substrate binding site [chemical binding]; other site 470137006944 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 470137006945 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 470137006946 putative FMN binding site [chemical binding]; other site 470137006947 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 470137006948 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 470137006949 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 470137006950 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 470137006951 active site 470137006952 dimer interface [polypeptide binding]; other site 470137006953 motif 1; other site 470137006954 motif 2; other site 470137006955 motif 3; other site 470137006956 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 470137006957 anticodon binding site; other site 470137006958 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 470137006959 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 470137006960 Sporulation related domain; Region: SPOR; pfam05036 470137006961 hypothetical protein; Validated; Region: PRK00041 470137006962 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 470137006963 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 470137006964 trimerization site [polypeptide binding]; other site 470137006965 active site 470137006966 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 470137006967 homodecamer interface [polypeptide binding]; other site 470137006968 GTP cyclohydrolase I; Provisional; Region: PLN03044 470137006969 active site 470137006970 putative catalytic site residues [active] 470137006971 zinc binding site [ion binding]; other site 470137006972 GTP-CH-I/GFRP interaction surface; other site 470137006973 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 470137006974 hypothetical protein; Provisional; Region: PRK10279 470137006975 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 470137006976 nucleophile elbow; other site 470137006977 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 470137006978 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 470137006979 active site 470137006980 DNA binding site [nucleotide binding] 470137006981 Int/Topo IB signature motif; other site 470137006982 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 470137006983 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 470137006984 catalytic residues [active] 470137006985 catalytic nucleophile [active] 470137006986 Presynaptic Site I dimer interface [polypeptide binding]; other site 470137006987 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 470137006988 Synaptic Flat tetramer interface [polypeptide binding]; other site 470137006989 Synaptic Site I dimer interface [polypeptide binding]; other site 470137006990 DNA binding site [nucleotide binding] 470137006991 BRO family, N-terminal domain; Region: Bro-N; cl10591 470137006992 Prophage antirepressor [Transcription]; Region: COG3617 470137006993 BRO family, N-terminal domain; Region: Bro-N; smart01040 470137006994 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 470137006995 CoA-transferase family III; Region: CoA_transf_3; pfam02515 470137006996 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 470137006997 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 470137006998 FAD binding site [chemical binding]; other site 470137006999 substrate binding pocket [chemical binding]; other site 470137007000 catalytic base [active] 470137007001 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 470137007002 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 470137007003 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 470137007004 dimerization interface [polypeptide binding]; other site 470137007005 substrate binding pocket [chemical binding]; other site 470137007006 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 470137007007 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 470137007008 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 470137007009 multidrug efflux protein; Reviewed; Region: PRK09579 470137007010 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 470137007011 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 470137007012 HlyD family secretion protein; Region: HlyD_3; pfam13437 470137007013 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 470137007014 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 470137007015 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 470137007016 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 470137007017 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 470137007018 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 470137007019 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 470137007020 active site 470137007021 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 470137007022 active site 470137007023 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 470137007024 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 470137007025 active site 470137007026 (T/H)XGH motif; other site 470137007027 DNA gyrase subunit A; Validated; Region: PRK05560 470137007028 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 470137007029 CAP-like domain; other site 470137007030 active site 470137007031 primary dimer interface [polypeptide binding]; other site 470137007032 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 470137007033 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 470137007034 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 470137007035 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 470137007036 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 470137007037 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 470137007038 Uncharacterized component of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3709 470137007039 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 470137007040 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 470137007041 DNA-binding site [nucleotide binding]; DNA binding site 470137007042 UTRA domain; Region: UTRA; pfam07702 470137007043 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 470137007044 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 470137007045 dimer interface [polypeptide binding]; other site 470137007046 ssDNA binding site [nucleotide binding]; other site 470137007047 tetramer (dimer of dimers) interface [polypeptide binding]; other site 470137007048 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 470137007049 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 470137007050 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 470137007051 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 470137007052 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 470137007053 IHF dimer interface [polypeptide binding]; other site 470137007054 IHF - DNA interface [nucleotide binding]; other site 470137007055 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 470137007056 Found in ATP-dependent protease La (LON); Region: LON; smart00464 470137007057 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 470137007058 Walker A motif; other site 470137007059 ATP binding site [chemical binding]; other site 470137007060 Walker B motif; other site 470137007061 arginine finger; other site 470137007062 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 470137007063 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 470137007064 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 470137007065 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 470137007066 Walker A motif; other site 470137007067 ATP binding site [chemical binding]; other site 470137007068 Walker B motif; other site 470137007069 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 470137007070 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 470137007071 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 470137007072 oligomer interface [polypeptide binding]; other site 470137007073 active site residues [active] 470137007074 GTPases [General function prediction only]; Region: HflX; COG2262 470137007075 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 470137007076 HflX GTPase family; Region: HflX; cd01878 470137007077 G1 box; other site 470137007078 GTP/Mg2+ binding site [chemical binding]; other site 470137007079 Switch I region; other site 470137007080 G2 box; other site 470137007081 G3 box; other site 470137007082 Switch II region; other site 470137007083 G4 box; other site 470137007084 G5 box; other site 470137007085 bacterial Hfq-like; Region: Hfq; cd01716 470137007086 hexamer interface [polypeptide binding]; other site 470137007087 Sm1 motif; other site 470137007088 RNA binding site [nucleotide binding]; other site 470137007089 Sm2 motif; other site 470137007090 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 470137007091 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 470137007092 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 470137007093 active site 470137007094 phosphorylation site [posttranslational modification] 470137007095 intermolecular recognition site; other site 470137007096 dimerization interface [polypeptide binding]; other site 470137007097 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 470137007098 Walker A motif; other site 470137007099 ATP binding site [chemical binding]; other site 470137007100 Walker B motif; other site 470137007101 arginine finger; other site 470137007102 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 470137007103 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 470137007104 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 470137007105 dimerization interface [polypeptide binding]; other site 470137007106 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 470137007107 dimer interface [polypeptide binding]; other site 470137007108 phosphorylation site [posttranslational modification] 470137007109 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 470137007110 ATP binding site [chemical binding]; other site 470137007111 Mg2+ binding site [ion binding]; other site 470137007112 G-X-G motif; other site 470137007113 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 470137007114 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 470137007115 active site 470137007116 phosphorylation site [posttranslational modification] 470137007117 intermolecular recognition site; other site 470137007118 dimerization interface [polypeptide binding]; other site 470137007119 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 470137007120 Walker A motif; other site 470137007121 ATP binding site [chemical binding]; other site 470137007122 Walker B motif; other site 470137007123 arginine finger; other site 470137007124 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 470137007125 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 470137007126 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 470137007127 FMN binding site [chemical binding]; other site 470137007128 active site 470137007129 catalytic residues [active] 470137007130 substrate binding site [chemical binding]; other site 470137007131 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 470137007132 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 470137007133 substrate binding site; other site 470137007134 dimer interface; other site 470137007135 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 470137007136 homotrimer interaction site [polypeptide binding]; other site 470137007137 zinc binding site [ion binding]; other site 470137007138 CDP-binding sites; other site 470137007139 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 470137007140 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 470137007141 classical (c) SDRs; Region: SDR_c; cd05233 470137007142 NAD(P) binding site [chemical binding]; other site 470137007143 active site 470137007144 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 470137007145 putative coenzyme Q binding site [chemical binding]; other site 470137007146 lipoyl synthase; Provisional; Region: PRK05481 470137007147 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 470137007148 FeS/SAM binding site; other site 470137007149 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 470137007150 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 470137007151 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 470137007152 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 470137007153 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 470137007154 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 470137007155 E3 interaction surface; other site 470137007156 lipoyl attachment site [posttranslational modification]; other site 470137007157 e3 binding domain; Region: E3_binding; pfam02817 470137007158 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 470137007159 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 470137007160 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 470137007161 E3 interaction surface; other site 470137007162 lipoyl attachment site [posttranslational modification]; other site 470137007163 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 470137007164 alpha subunit interface [polypeptide binding]; other site 470137007165 TPP binding site [chemical binding]; other site 470137007166 heterodimer interface [polypeptide binding]; other site 470137007167 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 470137007168 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 470137007169 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 470137007170 tetramer interface [polypeptide binding]; other site 470137007171 TPP-binding site [chemical binding]; other site 470137007172 heterodimer interface [polypeptide binding]; other site 470137007173 phosphorylation loop region [posttranslational modification] 470137007174 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 470137007175 Septum formation initiator; Region: DivIC; pfam04977 470137007176 Methyltransferase domain; Region: Methyltransf_23; pfam13489 470137007177 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 470137007178 S-adenosylmethionine binding site [chemical binding]; other site 470137007179 enolase; Provisional; Region: eno; PRK00077 470137007180 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 470137007181 dimer interface [polypeptide binding]; other site 470137007182 metal binding site [ion binding]; metal-binding site 470137007183 substrate binding pocket [chemical binding]; other site 470137007184 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 470137007185 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 470137007186 CTP synthetase; Validated; Region: pyrG; PRK05380 470137007187 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 470137007188 Catalytic site [active] 470137007189 active site 470137007190 UTP binding site [chemical binding]; other site 470137007191 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 470137007192 active site 470137007193 putative oxyanion hole; other site 470137007194 catalytic triad [active] 470137007195 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 470137007196 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 470137007197 triosephosphate isomerase; Provisional; Region: PRK14565 470137007198 substrate binding site [chemical binding]; other site 470137007199 dimer interface [polypeptide binding]; other site 470137007200 catalytic triad [active] 470137007201 SurA N-terminal domain; Region: SurA_N_3; cl07813 470137007202 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 470137007203 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 470137007204 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 470137007205 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 470137007206 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 470137007207 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 470137007208 active site 470137007209 ribulose/triose binding site [chemical binding]; other site 470137007210 phosphate binding site [ion binding]; other site 470137007211 substrate (anthranilate) binding pocket [chemical binding]; other site 470137007212 product (indole) binding pocket [chemical binding]; other site 470137007213 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 470137007214 trimer interface [polypeptide binding]; other site 470137007215 dimer interface [polypeptide binding]; other site 470137007216 putative active site [active] 470137007217 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 470137007218 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 470137007219 dimer interface [polypeptide binding]; other site 470137007220 putative functional site; other site 470137007221 putative MPT binding site; other site 470137007222 LexA repressor; Validated; Region: PRK00215 470137007223 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 470137007224 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 470137007225 Catalytic site [active] 470137007226 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 470137007227 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 470137007228 Competence protein; Region: Competence; pfam03772 470137007229 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 470137007230 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 470137007231 active site 470137007232 HIGH motif; other site 470137007233 nucleotide binding site [chemical binding]; other site 470137007234 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 470137007235 active site 470137007236 KMSKS motif; other site 470137007237 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 470137007238 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 470137007239 dimer interface [polypeptide binding]; other site 470137007240 active site 470137007241 citrylCoA binding site [chemical binding]; other site 470137007242 NADH binding [chemical binding]; other site 470137007243 cationic pore residues; other site 470137007244 oxalacetate/citrate binding site [chemical binding]; other site 470137007245 coenzyme A binding site [chemical binding]; other site 470137007246 catalytic triad [active] 470137007247 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 470137007248 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 470137007249 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3494 470137007250 Acyl-[acyl carrier protein]; Region: LpxA; COG1043 470137007251 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 470137007252 active site 470137007253 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 470137007254 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 470137007255 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 470137007256 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 470137007257 trimer interface [polypeptide binding]; other site 470137007258 active site 470137007259 UDP-GlcNAc binding site [chemical binding]; other site 470137007260 lipid binding site [chemical binding]; lipid-binding site 470137007261 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 470137007262 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 470137007263 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 470137007264 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 470137007265 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 470137007266 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 470137007267 Surface antigen; Region: Bac_surface_Ag; pfam01103 470137007268 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 470137007269 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 470137007270 active site 470137007271 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 470137007272 protein binding site [polypeptide binding]; other site 470137007273 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 470137007274 putative substrate binding region [chemical binding]; other site 470137007275 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 470137007276 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 470137007277 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834 470137007278 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 470137007279 catalytic residue [active] 470137007280 putative FPP diphosphate binding site; other site 470137007281 putative FPP binding hydrophobic cleft; other site 470137007282 dimer interface [polypeptide binding]; other site 470137007283 putative IPP diphosphate binding site; other site 470137007284 ribosome recycling factor; Reviewed; Region: frr; PRK00083 470137007285 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 470137007286 hinge region; other site 470137007287 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 470137007288 putative nucleotide binding site [chemical binding]; other site 470137007289 uridine monophosphate binding site [chemical binding]; other site 470137007290 homohexameric interface [polypeptide binding]; other site 470137007291 elongation factor Ts; Provisional; Region: tsf; PRK09377 470137007292 UBA/TS-N domain; Region: UBA; pfam00627 470137007293 Elongation factor TS; Region: EF_TS; pfam00889 470137007294 Elongation factor TS; Region: EF_TS; pfam00889 470137007295 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 470137007296 rRNA interaction site [nucleotide binding]; other site 470137007297 S8 interaction site; other site 470137007298 putative laminin-1 binding site; other site 470137007299 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 470137007300 Domain of unknown function (DUF1849); Region: DUF1849; pfam08904 470137007301 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 470137007302 homotrimer interaction site [polypeptide binding]; other site 470137007303 putative active site [active] 470137007304 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_3; cd08585 470137007305 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 470137007306 putative active site [active] 470137007307 catalytic site [active] 470137007308 putative metal binding site [ion binding]; other site 470137007309 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146 470137007310 Protein of unknown function, DUF482; Region: DUF482; pfam04339 470137007311 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 470137007312 HIT family signature motif; other site 470137007313 catalytic residue [active] 470137007314 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 470137007315 Clp amino terminal domain; Region: Clp_N; pfam02861 470137007316 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 470137007317 Walker A motif; other site 470137007318 ATP binding site [chemical binding]; other site 470137007319 Walker B motif; other site 470137007320 arginine finger; other site 470137007321 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 470137007322 Walker A motif; other site 470137007323 ATP binding site [chemical binding]; other site 470137007324 Walker B motif; other site 470137007325 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 470137007326 Uncharacterized conserved protein [Function unknown]; Region: COG2127 470137007327 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 470137007328 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 470137007329 Sporulation related domain; Region: SPOR; pfam05036 470137007330 Uncharacterized conserved protein [Function unknown]; Region: COG5458 470137007331 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 470137007332 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 470137007333 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 470137007334 Uncharacterized conserved protein [Function unknown]; Region: COG1434 470137007335 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 470137007336 putative active site [active] 470137007337 Predicted membrane protein [Function unknown]; Region: COG3503 470137007338 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 470137007339 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 470137007340 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 470137007341 DNA binding residues [nucleotide binding] 470137007342 putative dimer interface [polypeptide binding]; other site 470137007343 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 470137007344 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 470137007345 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3803 470137007346 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 470137007347 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 470137007348 non-specific DNA binding site [nucleotide binding]; other site 470137007349 salt bridge; other site 470137007350 sequence-specific DNA binding site [nucleotide binding]; other site 470137007351 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 470137007352 Domain of unknown function (DUF955); Region: DUF955; pfam06114 470137007353 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 470137007354 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 470137007355 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 470137007356 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 470137007357 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 470137007358 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 470137007359 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 470137007360 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 470137007361 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 470137007362 carboxyltransferase (CT) interaction site; other site 470137007363 biotinylation site [posttranslational modification]; other site 470137007364 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 470137007365 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 470137007366 active site 470137007367 substrate binding site [chemical binding]; other site 470137007368 coenzyme B12 binding site [chemical binding]; other site 470137007369 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 470137007370 B12 binding site [chemical binding]; other site 470137007371 cobalt ligand [ion binding]; other site 470137007372 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 470137007373 DctM-like transporters; Region: DctM; pfam06808 470137007374 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 470137007375 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 470137007376 glutamate racemase; Provisional; Region: PRK00865 470137007377 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 470137007378 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 470137007379 intracellular protease, PfpI family; Region: PfpI; TIGR01382 470137007380 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 470137007381 conserved cys residue [active] 470137007382 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 470137007383 isocitrate dehydrogenase; Validated; Region: PRK08299 470137007384 alkaline phosphatase; Provisional; Region: PRK10518 470137007385 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 470137007386 dimer interface [polypeptide binding]; other site 470137007387 active site 470137007388 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 470137007389 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 470137007390 motif 1; other site 470137007391 active site 470137007392 motif 2; other site 470137007393 motif 3; other site 470137007394 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 470137007395 recombinase A; Provisional; Region: recA; PRK09354 470137007396 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 470137007397 hexamer interface [polypeptide binding]; other site 470137007398 Walker A motif; other site 470137007399 ATP binding site [chemical binding]; other site 470137007400 Walker B motif; other site 470137007401 putative outer membrane lipoprotein; Provisional; Region: PRK10510 470137007402 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 470137007403 ligand binding site [chemical binding]; other site 470137007404 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 470137007405 N-acetyl-D-glucosamine binding site [chemical binding]; other site 470137007406 catalytic residue [active] 470137007407 recombination factor protein RarA; Reviewed; Region: PRK13342 470137007408 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 470137007409 Walker A motif; other site 470137007410 ATP binding site [chemical binding]; other site 470137007411 Walker B motif; other site 470137007412 arginine finger; other site 470137007413 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 470137007414 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 470137007415 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 470137007416 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 470137007417 protein binding site [polypeptide binding]; other site 470137007418 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 470137007419 protein binding site [polypeptide binding]; other site 470137007420 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 470137007421 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 470137007422 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 470137007423 alphaNTD homodimer interface [polypeptide binding]; other site 470137007424 alphaNTD - beta interaction site [polypeptide binding]; other site 470137007425 alphaNTD - beta' interaction site [polypeptide binding]; other site 470137007426 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 470137007427 30S ribosomal protein S11; Validated; Region: PRK05309 470137007428 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 470137007429 30S ribosomal protein S13; Region: bact_S13; TIGR03631 470137007430 adenylate kinase; Reviewed; Region: adk; PRK00279 470137007431 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 470137007432 AMP-binding site [chemical binding]; other site 470137007433 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 470137007434 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 470137007435 SecY translocase; Region: SecY; pfam00344 470137007436 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 470137007437 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 470137007438 23S rRNA binding site [nucleotide binding]; other site 470137007439 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 470137007440 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 470137007441 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 470137007442 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 470137007443 5S rRNA interface [nucleotide binding]; other site 470137007444 23S rRNA interface [nucleotide binding]; other site 470137007445 L5 interface [polypeptide binding]; other site 470137007446 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 470137007447 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 470137007448 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 470137007449 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 470137007450 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 470137007451 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 470137007452 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 470137007453 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 470137007454 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 470137007455 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 470137007456 RNA binding site [nucleotide binding]; other site 470137007457 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 470137007458 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 470137007459 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 470137007460 23S rRNA interface [nucleotide binding]; other site 470137007461 putative translocon interaction site; other site 470137007462 signal recognition particle (SRP54) interaction site; other site 470137007463 L23 interface [polypeptide binding]; other site 470137007464 trigger factor interaction site; other site 470137007465 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 470137007466 23S rRNA interface [nucleotide binding]; other site 470137007467 5S rRNA interface [nucleotide binding]; other site 470137007468 putative antibiotic binding site [chemical binding]; other site 470137007469 L25 interface [polypeptide binding]; other site 470137007470 L27 interface [polypeptide binding]; other site 470137007471 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 470137007472 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 470137007473 G-X-X-G motif; other site 470137007474 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 470137007475 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 470137007476 putative translocon binding site; other site 470137007477 protein-rRNA interface [nucleotide binding]; other site 470137007478 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 470137007479 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 470137007480 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 470137007481 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 470137007482 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 470137007483 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 470137007484 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 470137007485 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 470137007486 elongation factor Tu; Reviewed; Region: PRK00049 470137007487 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 470137007488 G1 box; other site 470137007489 GEF interaction site [polypeptide binding]; other site 470137007490 GTP/Mg2+ binding site [chemical binding]; other site 470137007491 Switch I region; other site 470137007492 G2 box; other site 470137007493 G3 box; other site 470137007494 Switch II region; other site 470137007495 G4 box; other site 470137007496 G5 box; other site 470137007497 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 470137007498 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 470137007499 Antibiotic Binding Site [chemical binding]; other site 470137007500 elongation factor G; Reviewed; Region: PRK00007 470137007501 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 470137007502 G1 box; other site 470137007503 putative GEF interaction site [polypeptide binding]; other site 470137007504 GTP/Mg2+ binding site [chemical binding]; other site 470137007505 Switch I region; other site 470137007506 G2 box; other site 470137007507 G3 box; other site 470137007508 Switch II region; other site 470137007509 G4 box; other site 470137007510 G5 box; other site 470137007511 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 470137007512 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 470137007513 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 470137007514 30S ribosomal protein S7; Validated; Region: PRK05302 470137007515 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 470137007516 S17 interaction site [polypeptide binding]; other site 470137007517 S8 interaction site; other site 470137007518 16S rRNA interaction site [nucleotide binding]; other site 470137007519 streptomycin interaction site [chemical binding]; other site 470137007520 23S rRNA interaction site [nucleotide binding]; other site 470137007521 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 470137007522 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 470137007523 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 470137007524 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 470137007525 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 470137007526 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 470137007527 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 470137007528 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 470137007529 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 470137007530 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 470137007531 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 470137007532 DNA binding site [nucleotide binding] 470137007533 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 470137007534 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 470137007535 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 470137007536 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 470137007537 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 470137007538 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 470137007539 RPB11 interaction site [polypeptide binding]; other site 470137007540 RPB12 interaction site [polypeptide binding]; other site 470137007541 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 470137007542 RPB1 interaction site [polypeptide binding]; other site 470137007543 RPB11 interaction site [polypeptide binding]; other site 470137007544 RPB10 interaction site [polypeptide binding]; other site 470137007545 RPB3 interaction site [polypeptide binding]; other site 470137007546 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 470137007547 L11 interface [polypeptide binding]; other site 470137007548 putative EF-Tu interaction site [polypeptide binding]; other site 470137007549 putative EF-G interaction site [polypeptide binding]; other site 470137007550 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 470137007551 23S rRNA interface [nucleotide binding]; other site 470137007552 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 470137007553 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 470137007554 mRNA/rRNA interface [nucleotide binding]; other site 470137007555 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 470137007556 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 470137007557 23S rRNA interface [nucleotide binding]; other site 470137007558 L7/L12 interface [polypeptide binding]; other site 470137007559 putative thiostrepton binding site; other site 470137007560 L25 interface [polypeptide binding]; other site 470137007561 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 470137007562 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 470137007563 putative homodimer interface [polypeptide binding]; other site 470137007564 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 470137007565 heterodimer interface [polypeptide binding]; other site 470137007566 homodimer interface [polypeptide binding]; other site 470137007567 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 470137007568 elongation factor Tu; Reviewed; Region: PRK00049 470137007569 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 470137007570 G1 box; other site 470137007571 GEF interaction site [polypeptide binding]; other site 470137007572 GTP/Mg2+ binding site [chemical binding]; other site 470137007573 Switch I region; other site 470137007574 G2 box; other site 470137007575 G3 box; other site 470137007576 Switch II region; other site 470137007577 G4 box; other site 470137007578 G5 box; other site 470137007579 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 470137007580 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 470137007581 Antibiotic Binding Site [chemical binding]; other site 470137007582 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 470137007583 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 470137007584 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 470137007585 FOG: CBS domain [General function prediction only]; Region: COG0517 470137007586 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 470137007587 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 470137007588 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 470137007589 PAS domain; Region: PAS_5; pfam07310 470137007590 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 470137007591 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 470137007592 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 470137007593 trimer interface [polypeptide binding]; other site 470137007594 putative metal binding site [ion binding]; other site 470137007595 Protein of unknown function (DUF3126); Region: DUF3126; pfam11324 470137007596 serine acetyltransferase; Provisional; Region: cysE; PRK11132 470137007597 Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971 470137007598 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 470137007599 trimer interface [polypeptide binding]; other site 470137007600 active site 470137007601 substrate binding site [chemical binding]; other site 470137007602 CoA binding site [chemical binding]; other site 470137007603 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 470137007604 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 470137007605 Uncharacterized conserved protein [Function unknown]; Region: COG1430 470137007606 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 470137007607 DNA-binding site [nucleotide binding]; DNA binding site 470137007608 RNA-binding motif; other site 470137007609 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 470137007610 DNA-binding site [nucleotide binding]; DNA binding site 470137007611 RNA-binding motif; other site 470137007612 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 470137007613 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 470137007614 dimer interface [polypeptide binding]; other site 470137007615 active site 470137007616 metal binding site [ion binding]; metal-binding site 470137007617 glutathione binding site [chemical binding]; other site 470137007618 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 470137007619 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 470137007620 DHH family; Region: DHH; pfam01368 470137007621 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 470137007622 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 470137007623 ATP-grasp domain; Region: ATP-grasp_4; cl17255 470137007624 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 470137007625 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 470137007626 putative active site [active] 470137007627 homoserine dehydrogenase; Provisional; Region: PRK06349 470137007628 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 470137007629 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 470137007630 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 470137007631 aminotransferase; Validated; Region: PRK09148 470137007632 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 470137007633 pyridoxal 5'-phosphate binding site [chemical binding]; other site 470137007634 homodimer interface [polypeptide binding]; other site 470137007635 catalytic residue [active] 470137007636 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 470137007637 Peptidase M15; Region: Peptidase_M15_3; cl01194 470137007638 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3553 470137007639 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 470137007640 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 470137007641 active site 470137007642 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 470137007643 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 470137007644 MPN+ (JAMM) motif; other site 470137007645 Zinc-binding site [ion binding]; other site 470137007646 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 470137007647 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 470137007648 active site 470137007649 SAM binding site [chemical binding]; other site 470137007650 putative homodimer interface [polypeptide binding]; other site 470137007651 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 470137007652 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 470137007653 S-adenosylmethionine binding site [chemical binding]; other site 470137007654 precorrin-3B synthase; Region: CobG; TIGR02435 470137007655 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 470137007656 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 470137007657 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 470137007658 Precorrin-8X methylmutase; Region: CbiC; pfam02570 470137007659 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 470137007660 active site 470137007661 SAM binding site [chemical binding]; other site 470137007662 homodimer interface [polypeptide binding]; other site 470137007663 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 470137007664 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 470137007665 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 470137007666 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 470137007667 active site 470137007668 SAM binding site [chemical binding]; other site 470137007669 homodimer interface [polypeptide binding]; other site 470137007670 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 470137007671 Flavin Reductases; Region: FlaRed; cl00801 470137007672 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 470137007673 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 470137007674 ligand binding site [chemical binding]; other site 470137007675 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 470137007676 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 470137007677 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 470137007678 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 470137007679 catalytic residue [active] 470137007680 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 470137007681 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 470137007682 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 470137007683 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 470137007684 active site 470137007685 SAM binding site [chemical binding]; other site 470137007686 homodimer interface [polypeptide binding]; other site 470137007687 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 470137007688 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 470137007689 active site 470137007690 SAM binding site [chemical binding]; other site 470137007691 homodimer interface [polypeptide binding]; other site 470137007692 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 470137007693 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 470137007694 tellurium resistance terB-like protein; Region: terB_like; cd07177 470137007695 metal binding site [ion binding]; metal-binding site 470137007696 hypothetical protein; Provisional; Region: PRK10621 470137007697 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 470137007698 Predicted membrane protein [Function unknown]; Region: COG2510 470137007699 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 470137007700 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 470137007701 homodimer interface [polypeptide binding]; other site 470137007702 Walker A motif; other site 470137007703 ATP binding site [chemical binding]; other site 470137007704 hydroxycobalamin binding site [chemical binding]; other site 470137007705 Walker B motif; other site 470137007706 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 470137007707 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 470137007708 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 470137007709 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 470137007710 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 470137007711 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 470137007712 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 470137007713 homotrimer interface [polypeptide binding]; other site 470137007714 Walker A motif; other site 470137007715 GTP binding site [chemical binding]; other site 470137007716 Walker B motif; other site 470137007717 Predicted integral membrane protein [Function unknown]; Region: COG5446 470137007718 cobalt transporter subunit CbtB (proposed); Region: CbtB; TIGR02459 470137007719 cobyric acid synthase; Provisional; Region: PRK00784 470137007720 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 470137007721 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 470137007722 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 470137007723 catalytic triad [active] 470137007724 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 470137007725 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 470137007726 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 470137007727 Transcriptional regulator [Transcription]; Region: LysR; COG0583 470137007728 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 470137007729 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 470137007730 dimerization interface [polypeptide binding]; other site 470137007731 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 470137007732 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 470137007733 conserved cys residue [active] 470137007734 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 470137007735 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 470137007736 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 470137007737 hydroxyglutarate oxidase; Provisional; Region: PRK11728 470137007738 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 470137007739 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 470137007740 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 470137007741 Mechanosensitive ion channel; Region: MS_channel; pfam00924 470137007742 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 470137007743 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 470137007744 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 470137007745 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 470137007746 Protein export membrane protein; Region: SecD_SecF; pfam02355 470137007747 putative cation:proton antiport protein; Provisional; Region: PRK10669 470137007748 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 470137007749 TrkA-N domain; Region: TrkA_N; pfam02254 470137007750 Predicted integral membrane protein [Function unknown]; Region: COG0392 470137007751 Serine hydrolase; Region: Ser_hydrolase; pfam06821 470137007752 sulfate transport protein; Provisional; Region: cysT; CHL00187 470137007753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137007754 dimer interface [polypeptide binding]; other site 470137007755 conserved gate region; other site 470137007756 putative PBP binding loops; other site 470137007757 ABC-ATPase subunit interface; other site 470137007758 sulfate transport protein; Provisional; Region: cysT; CHL00187 470137007759 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137007760 dimer interface [polypeptide binding]; other site 470137007761 conserved gate region; other site 470137007762 putative PBP binding loops; other site 470137007763 ABC-ATPase subunit interface; other site 470137007764 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CysP; COG4150 470137007765 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 470137007766 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 470137007767 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 470137007768 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 470137007769 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 470137007770 Transporter associated domain; Region: CorC_HlyC; smart01091 470137007771 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 470137007772 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 470137007773 EF-hand domain pair; Region: EF_hand_5; pfam13499 470137007774 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 470137007775 Ca2+ binding site [ion binding]; other site 470137007776 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 470137007777 Ca2+ binding site [ion binding]; other site 470137007778 Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154 470137007779 short chain dehydrogenase; Provisional; Region: PRK06198 470137007780 classical (c) SDRs; Region: SDR_c; cd05233 470137007781 NAD(P) binding site [chemical binding]; other site 470137007782 active site 470137007783 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 470137007784 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 470137007785 Walker A/P-loop; other site 470137007786 ATP binding site [chemical binding]; other site 470137007787 Q-loop/lid; other site 470137007788 ABC transporter signature motif; other site 470137007789 Walker B; other site 470137007790 D-loop; other site 470137007791 H-loop/switch region; other site 470137007792 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 470137007793 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 470137007794 TM-ABC transporter signature motif; other site 470137007795 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 470137007796 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 470137007797 putative ligand binding site [chemical binding]; other site 470137007798 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 470137007799 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 470137007800 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 470137007801 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 470137007802 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 470137007803 Walker A/P-loop; other site 470137007804 ATP binding site [chemical binding]; other site 470137007805 Q-loop/lid; other site 470137007806 ABC transporter signature motif; other site 470137007807 Walker B; other site 470137007808 D-loop; other site 470137007809 H-loop/switch region; other site 470137007810 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 470137007811 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 470137007812 ABC-ATPase subunit interface; other site 470137007813 dimer interface [polypeptide binding]; other site 470137007814 putative PBP binding regions; other site 470137007815 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 470137007816 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 470137007817 intersubunit interface [polypeptide binding]; other site 470137007818 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 470137007819 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 470137007820 N-terminal plug; other site 470137007821 ligand-binding site [chemical binding]; other site 470137007822 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 470137007823 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 470137007824 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 470137007825 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 470137007826 Walker A/P-loop; other site 470137007827 ATP binding site [chemical binding]; other site 470137007828 Q-loop/lid; other site 470137007829 ABC transporter signature motif; other site 470137007830 Walker B; other site 470137007831 D-loop; other site 470137007832 H-loop/switch region; other site 470137007833 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 470137007834 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 470137007835 Walker A/P-loop; other site 470137007836 ATP binding site [chemical binding]; other site 470137007837 Q-loop/lid; other site 470137007838 ABC transporter signature motif; other site 470137007839 Walker B; other site 470137007840 D-loop; other site 470137007841 H-loop/switch region; other site 470137007842 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 470137007843 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 470137007844 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 470137007845 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 470137007846 HlyD family secretion protein; Region: HlyD_3; pfam13437 470137007847 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 470137007848 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 470137007849 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 470137007850 alpha-gamma subunit interface [polypeptide binding]; other site 470137007851 beta-gamma subunit interface [polypeptide binding]; other site 470137007852 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 470137007853 alpha-beta subunit interface [polypeptide binding]; other site 470137007854 urease subunit alpha; Reviewed; Region: ureC; PRK13309 470137007855 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 470137007856 subunit interactions [polypeptide binding]; other site 470137007857 active site 470137007858 flap region; other site 470137007859 urease accessory protein UreE; Provisional; Region: ureE; PRK14711 470137007860 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 470137007861 dimer interface [polypeptide binding]; other site 470137007862 catalytic residues [active] 470137007863 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 470137007864 UreF; Region: UreF; pfam01730 470137007865 Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413 470137007866 ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266 470137007867 cobalt transport protein CbiM; Validated; Region: PRK06265 470137007868 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 470137007869 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 470137007870 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 470137007871 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 470137007872 Walker A/P-loop; other site 470137007873 ATP binding site [chemical binding]; other site 470137007874 Q-loop/lid; other site 470137007875 ABC transporter signature motif; other site 470137007876 Walker B; other site 470137007877 D-loop; other site 470137007878 H-loop/switch region; other site 470137007879 camphor resistance protein CrcB; Provisional; Region: ccrB; PRK01636 470137007880 Uncharacterized conserved protein [Function unknown]; Region: COG3439 470137007881 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 470137007882 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 470137007883 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 470137007884 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 470137007885 nudix motif; other site 470137007886 BA14K-like protein; Region: BA14K; pfam07886 470137007887 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 470137007888 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 470137007889 pyridoxal 5'-phosphate binding site [chemical binding]; other site 470137007890 homodimer interface [polypeptide binding]; other site 470137007891 catalytic residue [active] 470137007892 ketol-acid reductoisomerase; Provisional; Region: PRK05479 470137007893 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 470137007894 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 470137007895 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 470137007896 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 470137007897 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 470137007898 potassium uptake protein; Region: kup; TIGR00794 470137007899 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cl00541 470137007900 active site 470137007901 hydrophilic channel; other site 470137007902 dimerization interface [polypeptide binding]; other site 470137007903 catalytic residues [active] 470137007904 active site lid [active] 470137007905 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 470137007906 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 470137007907 AAA domain; Region: AAA_30; pfam13604 470137007908 Family description; Region: UvrD_C_2; pfam13538 470137007909 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 470137007910 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 470137007911 putative valine binding site [chemical binding]; other site 470137007912 dimer interface [polypeptide binding]; other site 470137007913 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 470137007914 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 470137007915 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 470137007916 PYR/PP interface [polypeptide binding]; other site 470137007917 dimer interface [polypeptide binding]; other site 470137007918 TPP binding site [chemical binding]; other site 470137007919 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 470137007920 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 470137007921 TPP-binding site [chemical binding]; other site 470137007922 dimer interface [polypeptide binding]; other site 470137007923 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 470137007924 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 470137007925 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 470137007926 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 470137007927 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 470137007928 motif II; other site 470137007929 Predicted flavoproteins [General function prediction only]; Region: COG2081 470137007930 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 470137007931 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 470137007932 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 470137007933 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 470137007934 protein binding site [polypeptide binding]; other site 470137007935 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 470137007936 protein binding site [polypeptide binding]; other site 470137007937 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 470137007938 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 470137007939 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 470137007940 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 470137007941 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 470137007942 HflK protein; Region: hflK; TIGR01933 470137007943 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 470137007944 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 470137007945 folate binding site [chemical binding]; other site 470137007946 NADP+ binding site [chemical binding]; other site 470137007947 thymidylate synthase; Reviewed; Region: thyA; PRK01827 470137007948 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 470137007949 dimerization interface [polypeptide binding]; other site 470137007950 active site 470137007951 Protein of unknown function (DUF2853); Region: DUF2853; pfam11015 470137007952 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 470137007953 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 470137007954 putative substrate translocation pore; other site 470137007955 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 470137007956 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 470137007957 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 470137007958 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814 470137007959 Domain of unknown function (DUF4169); Region: DUF4169; pfam13770 470137007960 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 470137007961 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 470137007962 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 470137007963 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 470137007964 FAD binding domain; Region: FAD_binding_4; pfam01565 470137007965 Uncharacterized conserved protein [Function unknown]; Region: COG4702 470137007966 serine/threonine protein kinase; Provisional; Region: PRK09188 470137007967 serine/threonine protein kinase; Provisional; Region: PRK12274 470137007968 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 470137007969 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 470137007970 Part of AAA domain; Region: AAA_19; pfam13245 470137007971 Family description; Region: UvrD_C_2; pfam13538 470137007972 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 470137007973 CreA protein; Region: CreA; pfam05981 470137007974 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 470137007975 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 470137007976 trimer interface [polypeptide binding]; other site 470137007977 active site 470137007978 substrate binding site [chemical binding]; other site 470137007979 CoA binding site [chemical binding]; other site 470137007980 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 470137007981 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 470137007982 Cu(I) binding site [ion binding]; other site 470137007983 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 470137007984 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 470137007985 S-adenosylmethionine binding site [chemical binding]; other site 470137007986 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 470137007987 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 470137007988 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 470137007989 active site 470137007990 Uncharacterized conserved protein [Function unknown]; Region: COG5587 470137007991 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 470137007992 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 470137007993 nucleotide binding pocket [chemical binding]; other site 470137007994 K-X-D-G motif; other site 470137007995 catalytic site [active] 470137007996 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 470137007997 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 470137007998 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 470137007999 Dimer interface [polypeptide binding]; other site 470137008000 BRCT sequence motif; other site 470137008001 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 470137008002 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 470137008003 Walker A/P-loop; other site 470137008004 ATP binding site [chemical binding]; other site 470137008005 Q-loop/lid; other site 470137008006 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 470137008007 ABC transporter signature motif; other site 470137008008 Walker B; other site 470137008009 D-loop; other site 470137008010 H-loop/switch region; other site 470137008011 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 470137008012 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 470137008013 binding surface 470137008014 TPR motif; other site 470137008015 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 470137008016 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 470137008017 cell division protein FtsZ; Validated; Region: PRK09330 470137008018 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 470137008019 nucleotide binding site [chemical binding]; other site 470137008020 SulA interaction site; other site 470137008021 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 470137008022 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 470137008023 Cell division protein FtsA; Region: FtsA; smart00842 470137008024 Cell division protein FtsA; Region: FtsA; pfam14450 470137008025 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 470137008026 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 470137008027 Cell division protein FtsQ; Region: FtsQ; pfam03799 470137008028 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 470137008029 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 470137008030 ATP-grasp domain; Region: ATP-grasp_4; cl17255 470137008031 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 470137008032 FAD binding domain; Region: FAD_binding_4; pfam01565 470137008033 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 470137008034 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 470137008035 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 470137008036 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 470137008037 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 470137008038 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 470137008039 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 470137008040 active site 470137008041 homodimer interface [polypeptide binding]; other site 470137008042 cell division protein FtsW; Region: ftsW; TIGR02614 470137008043 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 470137008044 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 470137008045 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 470137008046 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 470137008047 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 470137008048 Mg++ binding site [ion binding]; other site 470137008049 putative catalytic motif [active] 470137008050 putative substrate binding site [chemical binding]; other site 470137008051 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093 470137008052 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 470137008053 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 470137008054 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 470137008055 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 470137008056 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 470137008057 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 470137008058 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 470137008059 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 470137008060 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 470137008061 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 470137008062 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 470137008063 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 470137008064 MraW methylase family; Region: Methyltransf_5; cl17771 470137008065 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 470137008066 manganese transport protein MntH; Reviewed; Region: PRK00701 470137008067 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 470137008068 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 470137008069 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 470137008070 amidase catalytic site [active] 470137008071 Zn binding residues [ion binding]; other site 470137008072 substrate binding site [chemical binding]; other site 470137008073 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 470137008074 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 470137008075 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 470137008076 putative metal binding site [ion binding]; other site 470137008077 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 470137008078 HSP70 interaction site [polypeptide binding]; other site 470137008079 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 470137008080 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 470137008081 active site 470137008082 Predicted permeases [General function prediction only]; Region: COG0679 470137008083 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 470137008084 FAD binding site [chemical binding]; other site 470137008085 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 470137008086 dimerization interface [polypeptide binding]; other site 470137008087 putative DNA binding site [nucleotide binding]; other site 470137008088 putative Zn2+ binding site [ion binding]; other site 470137008089 Methyltransferase domain; Region: Methyltransf_23; pfam13489 470137008090 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 470137008091 S-adenosylmethionine binding site [chemical binding]; other site 470137008092 Uncharacterized conserved protein [Function unknown]; Region: COG5586 470137008093 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 470137008094 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 470137008095 S-adenosylmethionine binding site [chemical binding]; other site 470137008096 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 470137008097 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 470137008098 Walker A/P-loop; other site 470137008099 ATP binding site [chemical binding]; other site 470137008100 Q-loop/lid; other site 470137008101 ABC transporter signature motif; other site 470137008102 Walker B; other site 470137008103 D-loop; other site 470137008104 H-loop/switch region; other site 470137008105 ABC transporter; Region: ABC_tran_2; pfam12848 470137008106 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 470137008107 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 470137008108 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 470137008109 PGAP1-like protein; Region: PGAP1; pfam07819 470137008110 Protein of unknown function (DUF1498); Region: DUF1498; pfam07385 470137008111 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 470137008112 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 470137008113 [2Fe-2S] cluster binding site [ion binding]; other site 470137008114 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 470137008115 putative alpha subunit interface [polypeptide binding]; other site 470137008116 putative active site [active] 470137008117 putative substrate binding site [chemical binding]; other site 470137008118 Fe binding site [ion binding]; other site 470137008119 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 470137008120 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 470137008121 FAD binding pocket [chemical binding]; other site 470137008122 FAD binding motif [chemical binding]; other site 470137008123 phosphate binding motif [ion binding]; other site 470137008124 beta-alpha-beta structure motif; other site 470137008125 NAD binding pocket [chemical binding]; other site 470137008126 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 470137008127 catalytic loop [active] 470137008128 iron binding site [ion binding]; other site 470137008129 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 470137008130 PhnA protein; Region: PhnA; pfam03831 470137008131 Isochorismatase family; Region: Isochorismatase; pfam00857 470137008132 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 470137008133 catalytic triad [active] 470137008134 metal binding site [ion binding]; metal-binding site 470137008135 conserved cis-peptide bond; other site 470137008136 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899 470137008137 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 470137008138 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 470137008139 active site 470137008140 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 470137008141 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 470137008142 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 470137008143 active site 470137008144 catalytic residues [active] 470137008145 DNA binding site [nucleotide binding] 470137008146 Int/Topo IB signature motif; other site 470137008147 Uncharacterized conserved protein [Function unknown]; Region: COG2968 470137008148 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 470137008149 hypothetical protein; Provisional; Region: PRK05170 470137008150 Uncharacterized conserved protein [Function unknown]; Region: COG5453 470137008151 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 470137008152 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 470137008153 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 470137008154 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 470137008155 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 470137008156 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 470137008157 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 470137008158 DNA binding residues [nucleotide binding] 470137008159 DNA primase; Validated; Region: dnaG; PRK05667 470137008160 CHC2 zinc finger; Region: zf-CHC2; pfam01807 470137008161 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 470137008162 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 470137008163 active site 470137008164 metal binding site [ion binding]; metal-binding site 470137008165 interdomain interaction site; other site 470137008166 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 470137008167 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 470137008168 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 470137008169 PhoU domain; Region: PhoU; pfam01895 470137008170 PhoU domain; Region: PhoU; pfam01895 470137008171 Uncharacterized conserved protein [Function unknown]; Region: COG1610 470137008172 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 470137008173 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 470137008174 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 470137008175 catalytic site [active] 470137008176 subunit interface [polypeptide binding]; other site 470137008177 Predicted metalloprotease [General function prediction only]; Region: COG2321 470137008178 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 470137008179 Predicted membrane protein [Function unknown]; Region: COG5395 470137008180 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 470137008181 LytTr DNA-binding domain; Region: LytTR; pfam04397 470137008182 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 470137008183 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 470137008184 ATP-grasp domain; Region: ATP-grasp_4; cl17255 470137008185 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 470137008186 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 470137008187 ATP-grasp domain; Region: ATP-grasp_4; cl17255 470137008188 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 470137008189 IMP binding site; other site 470137008190 dimer interface [polypeptide binding]; other site 470137008191 partial ornithine binding site; other site 470137008192 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 470137008193 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 470137008194 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 470137008195 NUDIX domain; Region: NUDIX; pfam00293 470137008196 nudix motif; other site 470137008197 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 470137008198 DNA-binding site [nucleotide binding]; DNA binding site 470137008199 RNA-binding motif; other site 470137008200 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 470137008201 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 470137008202 putative C-terminal domain interface [polypeptide binding]; other site 470137008203 putative GSH binding site (G-site) [chemical binding]; other site 470137008204 putative dimer interface [polypeptide binding]; other site 470137008205 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 470137008206 N-terminal domain interface [polypeptide binding]; other site 470137008207 dimer interface [polypeptide binding]; other site 470137008208 substrate binding pocket (H-site) [chemical binding]; other site 470137008209 aspartate aminotransferase; Provisional; Region: PRK05764 470137008210 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 470137008211 pyridoxal 5'-phosphate binding site [chemical binding]; other site 470137008212 homodimer interface [polypeptide binding]; other site 470137008213 catalytic residue [active] 470137008214 Transcriptional regulator [Transcription]; Region: LysR; COG0583 470137008215 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 470137008216 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 470137008217 putative effector binding pocket; other site 470137008218 dimerization interface [polypeptide binding]; other site 470137008219 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 470137008220 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 470137008221 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 470137008222 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 470137008223 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 470137008224 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 470137008225 putative DNA binding site [nucleotide binding]; other site 470137008226 putative Zn2+ binding site [ion binding]; other site 470137008227 AsnC family; Region: AsnC_trans_reg; pfam01037 470137008228 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 470137008229 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 470137008230 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 470137008231 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 470137008232 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 470137008233 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 470137008234 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 470137008235 EamA-like transporter family; Region: EamA; pfam00892 470137008236 EamA-like transporter family; Region: EamA; pfam00892 470137008237 Protein of unknown function, DUF486; Region: DUF486; cl01236 470137008238 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921 470137008239 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 470137008240 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 470137008241 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 470137008242 Bacterial SH3 domain; Region: SH3_3; pfam08239 470137008243 excinuclease ABC subunit B; Provisional; Region: PRK05298 470137008244 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 470137008245 ATP binding site [chemical binding]; other site 470137008246 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 470137008247 nucleotide binding region [chemical binding]; other site 470137008248 ATP-binding site [chemical binding]; other site 470137008249 Ultra-violet resistance protein B; Region: UvrB; pfam12344 470137008250 UvrB/uvrC motif; Region: UVR; pfam02151 470137008251 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 470137008252 N-acetyl-D-glucosamine binding site [chemical binding]; other site 470137008253 catalytic residue [active] 470137008254 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 470137008255 DNA-binding site [nucleotide binding]; DNA binding site 470137008256 RNA-binding motif; other site 470137008257 BA14K-like protein; Region: BA14K; pfam07886 470137008258 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 470137008259 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 470137008260 MarR family; Region: MarR_2; pfam12802 470137008261 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 470137008262 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 470137008263 active site 470137008264 phosphorylation site [posttranslational modification] 470137008265 intermolecular recognition site; other site 470137008266 dimerization interface [polypeptide binding]; other site 470137008267 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 470137008268 DNA binding site [nucleotide binding] 470137008269 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 470137008270 dimer interface [polypeptide binding]; other site 470137008271 phosphorylation site [posttranslational modification] 470137008272 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 470137008273 ATP binding site [chemical binding]; other site 470137008274 Mg2+ binding site [ion binding]; other site 470137008275 G-X-G motif; other site 470137008276 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 470137008277 dimer interface [polypeptide binding]; other site 470137008278 putative tRNA-binding site [nucleotide binding]; other site 470137008279 Uncharacterized conserved protein [Function unknown]; Region: COG5465 470137008280 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 470137008281 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 470137008282 Uncharacterized conserved protein [Function unknown]; Region: COG1565 470137008283 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 470137008284 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 470137008285 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 470137008286 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 470137008287 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 470137008288 active site 470137008289 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 470137008290 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 470137008291 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 470137008292 active site 470137008293 HerA helicase [Replication, recombination, and repair]; Region: COG0433 470137008294 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 470137008295 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 470137008296 5S rRNA interface [nucleotide binding]; other site 470137008297 CTC domain interface [polypeptide binding]; other site 470137008298 L16 interface [polypeptide binding]; other site 470137008299 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 470137008300 putative active site [active] 470137008301 catalytic residue [active] 470137008302 GTP-binding protein YchF; Reviewed; Region: PRK09601 470137008303 YchF GTPase; Region: YchF; cd01900 470137008304 G1 box; other site 470137008305 GTP/Mg2+ binding site [chemical binding]; other site 470137008306 Switch I region; other site 470137008307 G2 box; other site 470137008308 Switch II region; other site 470137008309 G3 box; other site 470137008310 G4 box; other site 470137008311 G5 box; other site 470137008312 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 470137008313 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 470137008314 putative active site [active] 470137008315 putative catalytic site [active] 470137008316 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 470137008317 putative active site [active] 470137008318 putative catalytic site [active] 470137008319 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 470137008320 active site 470137008321 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 470137008322 cytochrome b; Provisional; Region: CYTB; MTH00191 470137008323 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 470137008324 Qi binding site; other site 470137008325 intrachain domain interface; other site 470137008326 interchain domain interface [polypeptide binding]; other site 470137008327 heme bH binding site [chemical binding]; other site 470137008328 heme bL binding site [chemical binding]; other site 470137008329 Qo binding site; other site 470137008330 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 470137008331 interchain domain interface [polypeptide binding]; other site 470137008332 intrachain domain interface; other site 470137008333 Qi binding site; other site 470137008334 Qo binding site; other site 470137008335 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 470137008336 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 470137008337 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 470137008338 [2Fe-2S] cluster binding site [ion binding]; other site 470137008339 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 470137008340 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 470137008341 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 470137008342 Walker A/P-loop; other site 470137008343 ATP binding site [chemical binding]; other site 470137008344 Q-loop/lid; other site 470137008345 ABC transporter signature motif; other site 470137008346 Walker B; other site 470137008347 D-loop; other site 470137008348 H-loop/switch region; other site 470137008349 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 470137008350 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 470137008351 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 470137008352 Walker A/P-loop; other site 470137008353 ATP binding site [chemical binding]; other site 470137008354 Q-loop/lid; other site 470137008355 ABC transporter signature motif; other site 470137008356 Walker B; other site 470137008357 D-loop; other site 470137008358 H-loop/switch region; other site 470137008359 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 470137008360 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 470137008361 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752 470137008362 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 470137008363 Coenzyme A binding pocket [chemical binding]; other site 470137008364 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 470137008365 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 470137008366 active site 470137008367 NTP binding site [chemical binding]; other site 470137008368 metal binding triad [ion binding]; metal-binding site 470137008369 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 470137008370 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 470137008371 putative active site [active] 470137008372 putative CoA binding site [chemical binding]; other site 470137008373 nudix motif; other site 470137008374 metal binding site [ion binding]; metal-binding site 470137008375 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816 470137008376 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 470137008377 MoxR-like ATPases [General function prediction only]; Region: COG0714 470137008378 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 470137008379 ATP binding site [chemical binding]; other site 470137008380 Walker B motif; other site 470137008381 arginine finger; other site 470137008382 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 470137008383 Protein of unknown function DUF58; Region: DUF58; pfam01882 470137008384 N-terminal double-transmembrane domain; Region: two_anch; TIGR02226 470137008385 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 470137008386 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 470137008387 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 470137008388 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 470137008389 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 470137008390 Coenzyme A binding pocket [chemical binding]; other site 470137008391 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 470137008392 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 470137008393 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 470137008394 putative dimer interface [polypeptide binding]; other site 470137008395 N-terminal domain interface [polypeptide binding]; other site 470137008396 putative substrate binding pocket (H-site) [chemical binding]; other site 470137008397 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 470137008398 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 470137008399 nudix motif; other site 470137008400 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 470137008401 active site 470137008402 metal binding site [ion binding]; metal-binding site 470137008403 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 470137008404 2-isopropylmalate synthase; Validated; Region: PRK03739 470137008405 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 470137008406 active site 470137008407 catalytic residues [active] 470137008408 metal binding site [ion binding]; metal-binding site 470137008409 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 470137008410 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 470137008411 Cation efflux family; Region: Cation_efflux; pfam01545 470137008412 anthranilate synthase; Provisional; Region: PRK13566 470137008413 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 470137008414 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 470137008415 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 470137008416 glutamine binding [chemical binding]; other site 470137008417 catalytic triad [active] 470137008418 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 470137008419 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 470137008420 putative DNA binding site [nucleotide binding]; other site 470137008421 putative Zn2+ binding site [ion binding]; other site 470137008422 AsnC family; Region: AsnC_trans_reg; pfam01037 470137008423 MarR family; Region: MarR_2; pfam12802 470137008424 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 470137008425 putative substrate translocation pore; other site 470137008426 Major Facilitator Superfamily; Region: MFS_1; pfam07690 470137008427 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG5459 470137008428 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5345 470137008429 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 470137008430 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 470137008431 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137008432 dimer interface [polypeptide binding]; other site 470137008433 conserved gate region; other site 470137008434 putative PBP binding loops; other site 470137008435 ABC-ATPase subunit interface; other site 470137008436 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 470137008437 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 470137008438 Walker A/P-loop; other site 470137008439 ATP binding site [chemical binding]; other site 470137008440 Q-loop/lid; other site 470137008441 ABC transporter signature motif; other site 470137008442 Walker B; other site 470137008443 D-loop; other site 470137008444 H-loop/switch region; other site 470137008445 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 470137008446 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 470137008447 Walker A/P-loop; other site 470137008448 ATP binding site [chemical binding]; other site 470137008449 Q-loop/lid; other site 470137008450 ABC transporter signature motif; other site 470137008451 Walker B; other site 470137008452 D-loop; other site 470137008453 H-loop/switch region; other site 470137008454 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 470137008455 dipeptide transporter; Provisional; Region: PRK10913 470137008456 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 470137008457 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137008458 dimer interface [polypeptide binding]; other site 470137008459 conserved gate region; other site 470137008460 putative PBP binding loops; other site 470137008461 ABC-ATPase subunit interface; other site 470137008462 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 470137008463 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137008464 dimer interface [polypeptide binding]; other site 470137008465 conserved gate region; other site 470137008466 putative PBP binding loops; other site 470137008467 ABC-ATPase subunit interface; other site 470137008468 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 470137008469 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 470137008470 dimerization interface [polypeptide binding]; other site 470137008471 putative DNA binding site [nucleotide binding]; other site 470137008472 putative Zn2+ binding site [ion binding]; other site 470137008473 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 470137008474 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 470137008475 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 470137008476 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 470137008477 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 470137008478 Ligand Binding Site [chemical binding]; other site 470137008479 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 470137008480 Predicted acetyltransferase [General function prediction only]; Region: COG2388 470137008481 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 470137008482 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5400 470137008483 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5385 470137008484 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 470137008485 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 470137008486 active site 470137008487 phosphorylation site [posttranslational modification] 470137008488 intermolecular recognition site; other site 470137008489 dimerization interface [polypeptide binding]; other site 470137008490 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 470137008491 DNA binding site [nucleotide binding] 470137008492 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 470137008493 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 470137008494 inhibitor-cofactor binding pocket; inhibition site 470137008495 pyridoxal 5'-phosphate binding site [chemical binding]; other site 470137008496 catalytic residue [active] 470137008497 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 470137008498 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 470137008499 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 470137008500 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 470137008501 PAS domain; Region: PAS_8; pfam13188 470137008502 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 470137008503 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 470137008504 putative active site [active] 470137008505 heme pocket [chemical binding]; other site 470137008506 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 470137008507 dimer interface [polypeptide binding]; other site 470137008508 phosphorylation site [posttranslational modification] 470137008509 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 470137008510 ATP binding site [chemical binding]; other site 470137008511 Mg2+ binding site [ion binding]; other site 470137008512 G-X-G motif; other site 470137008513 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 470137008514 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 470137008515 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 470137008516 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137008517 dimer interface [polypeptide binding]; other site 470137008518 conserved gate region; other site 470137008519 putative PBP binding loops; other site 470137008520 ABC-ATPase subunit interface; other site 470137008521 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137008522 dimer interface [polypeptide binding]; other site 470137008523 conserved gate region; other site 470137008524 putative PBP binding loops; other site 470137008525 ABC-ATPase subunit interface; other site 470137008526 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 470137008527 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 470137008528 Walker A/P-loop; other site 470137008529 ATP binding site [chemical binding]; other site 470137008530 Q-loop/lid; other site 470137008531 ABC transporter signature motif; other site 470137008532 Walker B; other site 470137008533 D-loop; other site 470137008534 H-loop/switch region; other site 470137008535 TOBE domain; Region: TOBE_2; pfam08402 470137008536 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 470137008537 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 470137008538 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 470137008539 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 470137008540 non-specific DNA binding site [nucleotide binding]; other site 470137008541 salt bridge; other site 470137008542 sequence-specific DNA binding site [nucleotide binding]; other site 470137008543 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 470137008544 Domain of unknown function (DUF955); Region: DUF955; pfam06114 470137008545 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 470137008546 isocitrate lyase; Provisional; Region: PRK15063 470137008547 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 470137008548 tetramer interface [polypeptide binding]; other site 470137008549 active site 470137008550 Mg2+/Mn2+ binding site [ion binding]; other site 470137008551 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 470137008552 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 470137008553 NAD binding site [chemical binding]; other site 470137008554 substrate binding site [chemical binding]; other site 470137008555 homotetramer interface [polypeptide binding]; other site 470137008556 homodimer interface [polypeptide binding]; other site 470137008557 active site 470137008558 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 470137008559 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 470137008560 NAD binding site [chemical binding]; other site 470137008561 substrate binding site [chemical binding]; other site 470137008562 homotetramer interface [polypeptide binding]; other site 470137008563 homodimer interface [polypeptide binding]; other site 470137008564 active site 470137008565 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 470137008566 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 470137008567 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 470137008568 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 470137008569 active site 470137008570 nucleophile elbow; other site 470137008571 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 470137008572 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 470137008573 DAK2 domain; Region: Dak2; cl03685 470137008574 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 470137008575 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 470137008576 DNA binding residues [nucleotide binding] 470137008577 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 470137008578 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 470137008579 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 470137008580 DAK2 domain; Region: Dak2; pfam02734 470137008581 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 470137008582 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 470137008583 short chain dehydrogenase; Provisional; Region: PRK06841 470137008584 classical (c) SDRs; Region: SDR_c; cd05233 470137008585 NAD(P) binding site [chemical binding]; other site 470137008586 active site 470137008587 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 470137008588 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 470137008589 putative ligand binding site [chemical binding]; other site 470137008590 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 470137008591 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 470137008592 TM-ABC transporter signature motif; other site 470137008593 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 470137008594 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 470137008595 Walker A/P-loop; other site 470137008596 ATP binding site [chemical binding]; other site 470137008597 Q-loop/lid; other site 470137008598 ABC transporter signature motif; other site 470137008599 Walker B; other site 470137008600 D-loop; other site 470137008601 H-loop/switch region; other site 470137008602 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 470137008603 Uncharacterized conserved protein [Function unknown]; Region: COG5591 470137008604 choline dehydrogenase; Validated; Region: PRK02106 470137008605 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 470137008606 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 470137008607 Peptidase family M23; Region: Peptidase_M23; pfam01551 470137008608 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 470137008609 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 470137008610 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 470137008611 Clp amino terminal domain; Region: Clp_N; pfam02861 470137008612 Clp amino terminal domain; Region: Clp_N; pfam02861 470137008613 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 470137008614 Walker A motif; other site 470137008615 ATP binding site [chemical binding]; other site 470137008616 Walker B motif; other site 470137008617 arginine finger; other site 470137008618 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 470137008619 Walker A motif; other site 470137008620 ATP binding site [chemical binding]; other site 470137008621 Walker B motif; other site 470137008622 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 470137008623 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 470137008624 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 470137008625 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 470137008626 S-adenosylmethionine binding site [chemical binding]; other site 470137008627 peptide chain release factor 1; Validated; Region: prfA; PRK00591 470137008628 This domain is found in peptide chain release factors; Region: PCRF; smart00937 470137008629 RF-1 domain; Region: RF-1; pfam00472 470137008630 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 470137008631 GAF domain; Region: GAF; pfam01590 470137008632 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 470137008633 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 470137008634 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 470137008635 aspartate kinase; Reviewed; Region: PRK06635 470137008636 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 470137008637 putative nucleotide binding site [chemical binding]; other site 470137008638 putative catalytic residues [active] 470137008639 putative Mg ion binding site [ion binding]; other site 470137008640 putative aspartate binding site [chemical binding]; other site 470137008641 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 470137008642 putative allosteric regulatory site; other site 470137008643 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 470137008644 putative allosteric regulatory residue; other site 470137008645 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 470137008646 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 470137008647 S-adenosylmethionine binding site [chemical binding]; other site 470137008648 EamA-like transporter family; Region: EamA; pfam00892 470137008649 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 470137008650 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5319 470137008651 Predicted amidohydrolase [General function prediction only]; Region: COG0388 470137008652 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 470137008653 putative active site [active] 470137008654 catalytic triad [active] 470137008655 dimer interface [polypeptide binding]; other site 470137008656 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 470137008657 GSH binding site [chemical binding]; other site 470137008658 catalytic residues [active] 470137008659 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 470137008660 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 470137008661 active site 470137008662 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 470137008663 Methyltransferase domain; Region: Methyltransf_11; pfam08241 470137008664 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 470137008665 putative metal binding site [ion binding]; other site 470137008666 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 470137008667 HemY protein N-terminus; Region: HemY_N; pfam07219 470137008668 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223 470137008669 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 470137008670 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 470137008671 active site 470137008672 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 470137008673 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 470137008674 domain interfaces; other site 470137008675 active site 470137008676 UGMP family protein; Validated; Region: PRK09604 470137008677 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 470137008678 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 470137008679 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 470137008680 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 470137008681 YCII-related domain; Region: YCII; cl00999 470137008682 Uncharacterized conserved protein [Function unknown]; Region: COG2947 470137008683 Predicted methyltransferase [General function prediction only]; Region: COG3897 470137008684 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 470137008685 S-adenosylmethionine binding site [chemical binding]; other site 470137008686 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 470137008687 EamA-like transporter family; Region: EamA; pfam00892 470137008688 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 470137008689 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 470137008690 DNA-binding site [nucleotide binding]; DNA binding site 470137008691 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 470137008692 pyridoxal 5'-phosphate binding site [chemical binding]; other site 470137008693 homodimer interface [polypeptide binding]; other site 470137008694 catalytic residue [active] 470137008695 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 470137008696 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 470137008697 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 470137008698 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 470137008699 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 470137008700 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333 470137008701 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 470137008702 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 470137008703 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 470137008704 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 470137008705 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 470137008706 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 470137008707 L-aspartate oxidase; Provisional; Region: PRK06175 470137008708 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 470137008709 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 470137008710 putative SdhC subunit interface [polypeptide binding]; other site 470137008711 putative proximal heme binding site [chemical binding]; other site 470137008712 putative Iron-sulfur protein interface [polypeptide binding]; other site 470137008713 putative proximal quinone binding site; other site 470137008714 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 470137008715 Iron-sulfur protein interface; other site 470137008716 proximal quinone binding site [chemical binding]; other site 470137008717 SdhD (CybS) interface [polypeptide binding]; other site 470137008718 proximal heme binding site [chemical binding]; other site 470137008719 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 470137008720 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 470137008721 Coenzyme A binding pocket [chemical binding]; other site 470137008722 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 470137008723 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 470137008724 substrate binding site [chemical binding]; other site 470137008725 ligand binding site [chemical binding]; other site 470137008726 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 470137008727 Cytosine/uracil/thiamine/allantoin permeases [Nucleotide transport and metabolism / Coenzyme metabolism]; Region: FUI1; COG1953 470137008728 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 470137008729 Na binding site [ion binding]; other site 470137008730 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 470137008731 NIPSNAP; Region: NIPSNAP; pfam07978 470137008732 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 470137008733 dimerization interface [polypeptide binding]; other site 470137008734 putative DNA binding site [nucleotide binding]; other site 470137008735 putative Zn2+ binding site [ion binding]; other site 470137008736 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 470137008737 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 470137008738 RimM N-terminal domain; Region: RimM; pfam01782 470137008739 PRC-barrel domain; Region: PRC; pfam05239 470137008740 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 470137008741 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 470137008742 active site 470137008743 DNA binding site [nucleotide binding] 470137008744 Int/Topo IB signature motif; other site 470137008745 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 470137008746 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 470137008747 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 470137008748 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 470137008749 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 470137008750 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 470137008751 Predicted membrane protein [Function unknown]; Region: COG3686 470137008752 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 470137008753 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 470137008754 E3 interaction surface; other site 470137008755 lipoyl attachment site [posttranslational modification]; other site 470137008756 e3 binding domain; Region: E3_binding; pfam02817 470137008757 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 470137008758 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 470137008759 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 470137008760 TPP-binding site [chemical binding]; other site 470137008761 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 470137008762 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 470137008763 CoA binding domain; Region: CoA_binding; smart00881 470137008764 CoA-ligase; Region: Ligase_CoA; pfam00549 470137008765 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 470137008766 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 470137008767 CoA-ligase; Region: Ligase_CoA; pfam00549 470137008768 malate dehydrogenase; Reviewed; Region: PRK06223 470137008769 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 470137008770 NAD(P) binding site [chemical binding]; other site 470137008771 dimer interface [polypeptide binding]; other site 470137008772 tetramer (dimer of dimers) interface [polypeptide binding]; other site 470137008773 substrate binding site [chemical binding]; other site 470137008774 Predicted ATPase [General function prediction only]; Region: COG1485 470137008775 Protease inhibitor Inh; Region: Inh; pfam02974 470137008776 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 470137008777 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 470137008778 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 470137008779 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 470137008780 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 470137008781 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 470137008782 FeS/SAM binding site; other site 470137008783 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 470137008784 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 470137008785 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 470137008786 intracellular septation protein A; Reviewed; Region: PRK00259 470137008787 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 470137008788 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 470137008789 active site 470137008790 8-oxo-dGMP binding site [chemical binding]; other site 470137008791 nudix motif; other site 470137008792 metal binding site [ion binding]; metal-binding site 470137008793 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 470137008794 Coenzyme A binding pocket [chemical binding]; other site 470137008795 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 470137008796 heterotetramer interface [polypeptide binding]; other site 470137008797 active site pocket [active] 470137008798 cleavage site 470137008799 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 470137008800 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 470137008801 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 470137008802 DEAD/DEAH box helicase; Region: DEAD; pfam00270 470137008803 ATP binding site [chemical binding]; other site 470137008804 putative Mg++ binding site [ion binding]; other site 470137008805 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 470137008806 SEC-C motif; Region: SEC-C; pfam02810 470137008807 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 470137008808 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 470137008809 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 470137008810 Sulfatase; Region: Sulfatase; pfam00884 470137008811 Transcriptional regulator [Transcription]; Region: LysR; COG0583 470137008812 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 470137008813 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 470137008814 dimerization interface [polypeptide binding]; other site 470137008815 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 470137008816 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 470137008817 substrate binding pocket [chemical binding]; other site 470137008818 membrane-bound complex binding site; other site 470137008819 hinge residues; other site 470137008820 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 470137008821 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137008822 dimer interface [polypeptide binding]; other site 470137008823 conserved gate region; other site 470137008824 putative PBP binding loops; other site 470137008825 ABC-ATPase subunit interface; other site 470137008826 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 470137008827 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137008828 dimer interface [polypeptide binding]; other site 470137008829 conserved gate region; other site 470137008830 putative PBP binding loops; other site 470137008831 ABC-ATPase subunit interface; other site 470137008832 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 470137008833 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 470137008834 Walker A/P-loop; other site 470137008835 ATP binding site [chemical binding]; other site 470137008836 Q-loop/lid; other site 470137008837 ABC transporter signature motif; other site 470137008838 Walker B; other site 470137008839 D-loop; other site 470137008840 H-loop/switch region; other site 470137008841 agmatinase; Region: agmatinase; TIGR01230 470137008842 Agmatinase and related proteins; Region: Agmatinase_like_1; cd11589 470137008843 oligomer interface [polypeptide binding]; other site 470137008844 active site 470137008845 Mn binding site [ion binding]; other site 470137008846 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 470137008847 Aspartase; Region: Aspartase; cd01357 470137008848 active sites [active] 470137008849 tetramer interface [polypeptide binding]; other site 470137008850 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 470137008851 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 470137008852 Walker A/P-loop; other site 470137008853 ATP binding site [chemical binding]; other site 470137008854 Q-loop/lid; other site 470137008855 ABC transporter signature motif; other site 470137008856 Walker B; other site 470137008857 D-loop; other site 470137008858 H-loop/switch region; other site 470137008859 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 470137008860 active site 470137008861 homotetramer interface [polypeptide binding]; other site 470137008862 homodimer interface [polypeptide binding]; other site 470137008863 Transcriptional regulators [Transcription]; Region: GntR; COG1802 470137008864 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 470137008865 DNA-binding site [nucleotide binding]; DNA binding site 470137008866 FCD domain; Region: FCD; pfam07729 470137008867 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 470137008868 active site 470137008869 homotetramer interface [polypeptide binding]; other site 470137008870 homodimer interface [polypeptide binding]; other site 470137008871 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 470137008872 D-galactonate transporter; Region: 2A0114; TIGR00893 470137008873 putative substrate translocation pore; other site 470137008874 methionine gamma-lyase; Validated; Region: PRK07049 470137008875 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 470137008876 homodimer interface [polypeptide binding]; other site 470137008877 substrate-cofactor binding pocket; other site 470137008878 pyridoxal 5'-phosphate binding site [chemical binding]; other site 470137008879 catalytic residue [active] 470137008880 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 470137008881 Ligand Binding Site [chemical binding]; other site 470137008882 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 470137008883 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 470137008884 dimer interface [polypeptide binding]; other site 470137008885 pyridoxal 5'-phosphate binding site [chemical binding]; other site 470137008886 catalytic residue [active] 470137008887 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 470137008888 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 470137008889 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 470137008890 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 470137008891 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 470137008892 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 470137008893 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 470137008894 Ligand binding site [chemical binding]; other site 470137008895 Electron transfer flavoprotein domain; Region: ETF; pfam01012 470137008896 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 470137008897 Ligand Binding Site [chemical binding]; other site 470137008898 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 470137008899 active site 470137008900 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 470137008901 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 470137008902 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 470137008903 Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588 470137008904 short chain dehydrogenase; Provisional; Region: PRK05993 470137008905 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 470137008906 NADP binding site [chemical binding]; other site 470137008907 active site 470137008908 steroid binding site; other site 470137008909 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 470137008910 hypothetical protein; Validated; Region: PRK00124 470137008911 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 470137008912 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 470137008913 catalytic residues [active] 470137008914 argininosuccinate lyase; Provisional; Region: PRK00855 470137008915 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 470137008916 active sites [active] 470137008917 tetramer interface [polypeptide binding]; other site 470137008918 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 470137008919 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 470137008920 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 470137008921 active site 470137008922 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 470137008923 substrate binding site [chemical binding]; other site 470137008924 catalytic residues [active] 470137008925 dimer interface [polypeptide binding]; other site 470137008926 TIGR02302 family protein; Region: aProt_lowcomp 470137008927 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 470137008928 active site 470137008929 Methyltransferase domain; Region: Methyltransf_23; pfam13489 470137008930 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 470137008931 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 470137008932 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 470137008933 pyridoxal 5'-phosphate binding site [chemical binding]; other site 470137008934 homodimer interface [polypeptide binding]; other site 470137008935 catalytic residue [active] 470137008936 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 470137008937 prephenate dehydrogenase; Validated; Region: PRK08507 470137008938 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4093 470137008939 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 470137008940 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 470137008941 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 470137008942 putative active site pocket [active] 470137008943 dimerization interface [polypeptide binding]; other site 470137008944 putative catalytic residue [active] 470137008945 YGGT family; Region: YGGT; pfam02325 470137008946 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 470137008947 dimer interface [polypeptide binding]; other site 470137008948 substrate binding site [chemical binding]; other site 470137008949 metal binding sites [ion binding]; metal-binding site 470137008950 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 470137008951 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 470137008952 putative acyl-acceptor binding pocket; other site 470137008953 Uncharacterized conserved protein [Function unknown]; Region: COG1434 470137008954 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 470137008955 putative active site [active] 470137008956 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 470137008957 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 470137008958 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 470137008959 Walker A/P-loop; other site 470137008960 ATP binding site [chemical binding]; other site 470137008961 Q-loop/lid; other site 470137008962 ABC transporter signature motif; other site 470137008963 Walker B; other site 470137008964 D-loop; other site 470137008965 H-loop/switch region; other site 470137008966 aquaporin Z; Provisional; Region: PRK05420 470137008967 amphipathic channel; other site 470137008968 Asn-Pro-Ala signature motifs; other site 470137008969 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 470137008970 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 470137008971 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 470137008972 putative catalytic site [active] 470137008973 putative phosphate binding site [ion binding]; other site 470137008974 active site 470137008975 metal binding site A [ion binding]; metal-binding site 470137008976 DNA binding site [nucleotide binding] 470137008977 putative AP binding site [nucleotide binding]; other site 470137008978 putative metal binding site B [ion binding]; other site 470137008979 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 470137008980 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 470137008981 ligand binding site [chemical binding]; other site 470137008982 flexible hinge region; other site 470137008983 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 470137008984 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 470137008985 active site 470137008986 phosphorylation site [posttranslational modification] 470137008987 intermolecular recognition site; other site 470137008988 dimerization interface [polypeptide binding]; other site 470137008989 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 470137008990 DNA binding site [nucleotide binding] 470137008991 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 470137008992 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 470137008993 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 470137008994 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 470137008995 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 470137008996 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 470137008997 DNA binding residues [nucleotide binding] 470137008998 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 470137008999 dimer interface [polypeptide binding]; other site 470137009000 putative metal binding site [ion binding]; other site 470137009001 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 470137009002 metal-binding site [ion binding] 470137009003 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 470137009004 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 470137009005 metal-binding site [ion binding] 470137009006 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 470137009007 Soluble P-type ATPase [General function prediction only]; Region: COG4087 470137009008 Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase) [Coenzyme metabolism]; Region: CobT; COG4547 470137009009 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 470137009010 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 470137009011 metal ion-dependent adhesion site (MIDAS); other site 470137009012 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 470137009013 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 470137009014 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 470137009015 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 470137009016 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 470137009017 HSP70 interaction site [polypeptide binding]; other site 470137009018 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 470137009019 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 470137009020 Domain of unknown function DUF21; Region: DUF21; pfam01595 470137009021 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 470137009022 Transporter associated domain; Region: CorC_HlyC; smart01091 470137009023 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 470137009024 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 470137009025 active site 470137009026 dimer interface [polypeptide binding]; other site 470137009027 metal binding site [ion binding]; metal-binding site 470137009028 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 470137009029 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 470137009030 ADP binding site [chemical binding]; other site 470137009031 magnesium binding site [ion binding]; other site 470137009032 putative shikimate binding site; other site 470137009033 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 470137009034 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 470137009035 active site 470137009036 DNA binding site [nucleotide binding] 470137009037 Int/Topo IB signature motif; other site 470137009038 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 470137009039 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 470137009040 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 470137009041 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 470137009042 CPxP motif; other site 470137009043 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 470137009044 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 470137009045 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 470137009046 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 470137009047 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 470137009048 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 470137009049 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 470137009050 NAD(P) binding site [chemical binding]; other site 470137009051 active site 470137009052 Uncharacterized conserved protein [Function unknown]; Region: COG3791 470137009053 Domain of unknown function (DUF4354); Region: DUF4354; pfam14263 470137009054 choline dehydrogenase; Validated; Region: PRK02106 470137009055 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 470137009056 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 470137009057 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 470137009058 NAD(P) binding site [chemical binding]; other site 470137009059 active site 470137009060 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 470137009061 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 470137009062 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 470137009063 Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118 470137009064 NAD(P) binding site [chemical binding]; other site 470137009065 catalytic residues [active] 470137009066 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 470137009067 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 470137009068 substrate binding site [chemical binding]; other site 470137009069 oxyanion hole (OAH) forming residues; other site 470137009070 trimer interface [polypeptide binding]; other site 470137009071 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 470137009072 Coenzyme A transferase; Region: CoA_trans; smart00882 470137009073 Coenzyme A transferase; Region: CoA_trans; cl17247 470137009074 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 470137009075 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 470137009076 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 470137009077 Transcriptional regulators [Transcription]; Region: PurR; COG1609 470137009078 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 470137009079 DNA binding site [nucleotide binding] 470137009080 domain linker motif; other site 470137009081 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 470137009082 putative dimerization interface [polypeptide binding]; other site 470137009083 putative ligand binding site [chemical binding]; other site 470137009084 Protein of unknown function (DUF993); Region: DUF993; pfam06187 470137009085 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 470137009086 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 470137009087 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 470137009088 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 470137009089 zinc binding site [ion binding]; other site 470137009090 putative ligand binding site [chemical binding]; other site 470137009091 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 470137009092 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 470137009093 TM-ABC transporter signature motif; other site 470137009094 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 470137009095 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 470137009096 Walker A/P-loop; other site 470137009097 ATP binding site [chemical binding]; other site 470137009098 Q-loop/lid; other site 470137009099 ABC transporter signature motif; other site 470137009100 Walker B; other site 470137009101 D-loop; other site 470137009102 H-loop/switch region; other site 470137009103 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 470137009104 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 470137009105 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 470137009106 ParB-like nuclease domain; Region: ParB; smart00470 470137009107 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 470137009108 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 470137009109 P-loop; other site 470137009110 Magnesium ion binding site [ion binding]; other site 470137009111 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 470137009112 Magnesium ion binding site [ion binding]; other site 470137009113 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 470137009114 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 470137009115 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 470137009116 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 470137009117 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 470137009118 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 470137009119 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 470137009120 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 470137009121 trmE is a tRNA modification GTPase; Region: trmE; cd04164 470137009122 G1 box; other site 470137009123 GTP/Mg2+ binding site [chemical binding]; other site 470137009124 Switch I region; other site 470137009125 G2 box; other site 470137009126 Switch II region; other site 470137009127 G3 box; other site 470137009128 G4 box; other site 470137009129 G5 box; other site 470137009130 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 470137009131 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 470137009132 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 470137009133 catalytic residues [active] 470137009134 transcription termination factor Rho; Provisional; Region: rho; PRK09376 470137009135 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 470137009136 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 470137009137 RNA binding site [nucleotide binding]; other site 470137009138 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 470137009139 multimer interface [polypeptide binding]; other site 470137009140 Walker A motif; other site 470137009141 ATP binding site [chemical binding]; other site 470137009142 Walker B motif; other site 470137009143 Predicted membrane protein [Function unknown]; Region: COG1981 470137009144 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 470137009145 substrate binding site [chemical binding]; other site 470137009146 active site 470137009147 PEP synthetase regulatory protein; Provisional; Region: PRK05339 470137009148 Maf-like protein; Reviewed; Region: PRK00078 470137009149 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 470137009150 active site 470137009151 dimer interface [polypeptide binding]; other site 470137009152 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 470137009153 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 470137009154 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 470137009155 shikimate binding site; other site 470137009156 NAD(P) binding site [chemical binding]; other site 470137009157 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 470137009158 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 470137009159 CoA-binding site [chemical binding]; other site 470137009160 ATP-binding [chemical binding]; other site 470137009161 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 470137009162 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 470137009163 active site 470137009164 catalytic site [active] 470137009165 substrate binding site [chemical binding]; other site 470137009166 preprotein translocase subunit SecB; Validated; Region: PRK05751 470137009167 SecA binding site; other site 470137009168 Preprotein binding site; other site 470137009169 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 470137009170 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 470137009171 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 470137009172 MltA specific insert domain; Region: MltA; pfam03562 470137009173 3D domain; Region: 3D; pfam06725 470137009174 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 470137009175 Smr domain; Region: Smr; pfam01713 470137009176 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 470137009177 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 470137009178 sequence-specific DNA binding site [nucleotide binding]; other site 470137009179 salt bridge; other site 470137009180 Protein of unknown function (DUF1402); Region: DUF1402; pfam07182 470137009181 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 470137009182 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 470137009183 Walker A motif; other site 470137009184 ATP binding site [chemical binding]; other site 470137009185 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 470137009186 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 470137009187 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 470137009188 active site 470137009189 HslU subunit interaction site [polypeptide binding]; other site 470137009190 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 470137009191 putative active site pocket [active] 470137009192 4-fold oligomerization interface [polypeptide binding]; other site 470137009193 metal binding residues [ion binding]; metal-binding site 470137009194 3-fold/trimer interface [polypeptide binding]; other site 470137009195 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 470137009196 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 470137009197 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 470137009198 putative active site [active] 470137009199 oxyanion strand; other site 470137009200 catalytic triad [active] 470137009201 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 470137009202 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 470137009203 catalytic residues [active] 470137009204 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 470137009205 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 470137009206 substrate binding site [chemical binding]; other site 470137009207 glutamase interaction surface [polypeptide binding]; other site 470137009208 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 470137009209 metal binding site [ion binding]; metal-binding site 470137009210 pantothenate kinase; Provisional; Region: PRK05439 470137009211 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 470137009212 ATP-binding site [chemical binding]; other site 470137009213 CoA-binding site [chemical binding]; other site 470137009214 Mg2+-binding site [ion binding]; other site 470137009215 hypothetical protein; Provisional; Region: PRK09256 470137009216 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 470137009217 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 470137009218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 470137009219 active site 470137009220 phosphorylation site [posttranslational modification] 470137009221 intermolecular recognition site; other site 470137009222 dimerization interface [polypeptide binding]; other site 470137009223 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 470137009224 DNA binding site [nucleotide binding] 470137009225 Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755 470137009226 Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756 470137009227 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 470137009228 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 470137009229 dimerization interface [polypeptide binding]; other site 470137009230 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 470137009231 dimer interface [polypeptide binding]; other site 470137009232 phosphorylation site [posttranslational modification] 470137009233 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 470137009234 ATP binding site [chemical binding]; other site 470137009235 Mg2+ binding site [ion binding]; other site 470137009236 G-X-G motif; other site 470137009237 Serine kinase of the HPr protein, regulates carbohydrate metabolism [Signal transduction mechanisms]; Region: HprK; COG1493 470137009238 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 470137009239 Hpr binding site; other site 470137009240 active site 470137009241 homohexamer subunit interaction site [polypeptide binding]; other site 470137009242 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 470137009243 active pocket/dimerization site; other site 470137009244 active site 470137009245 phosphorylation site [posttranslational modification] 470137009246 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 470137009247 dimerization domain swap beta strand [polypeptide binding]; other site 470137009248 regulatory protein interface [polypeptide binding]; other site 470137009249 active site 470137009250 regulatory phosphorylation site [posttranslational modification]; other site 470137009251 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 470137009252 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 470137009253 homotetramer interface [polypeptide binding]; other site 470137009254 ligand binding site [chemical binding]; other site 470137009255 catalytic site [active] 470137009256 NAD binding site [chemical binding]; other site 470137009257 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 470137009258 PAS fold; Region: PAS_7; pfam12860 470137009259 PAS fold; Region: PAS_7; pfam12860 470137009260 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 470137009261 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 470137009262 dimer interface [polypeptide binding]; other site 470137009263 phosphorylation site [posttranslational modification] 470137009264 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 470137009265 ATP binding site [chemical binding]; other site 470137009266 Mg2+ binding site [ion binding]; other site 470137009267 G-X-G motif; other site 470137009268 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 470137009269 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 470137009270 Phosphotransferase enzyme family; Region: APH; pfam01636 470137009271 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 470137009272 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 470137009273 Substrate binding site; other site 470137009274 metal-binding site 470137009275 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 470137009276 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 470137009277 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 470137009278 Family description; Region: UvrD_C_2; pfam13538 470137009279 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 470137009280 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 470137009281 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 470137009282 catalytic residues [active] 470137009283 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 470137009284 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 470137009285 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 470137009286 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 470137009287 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 470137009288 substrate binding site [chemical binding]; other site 470137009289 active site 470137009290 catalytic residues [active] 470137009291 heterodimer interface [polypeptide binding]; other site 470137009292 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 470137009293 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 470137009294 pyridoxal 5'-phosphate binding site [chemical binding]; other site 470137009295 catalytic residue [active] 470137009296 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 470137009297 active site 470137009298 Uncharacterized conserved protein [Function unknown]; Region: COG1434 470137009299 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 470137009300 putative active site [active] 470137009301 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 470137009302 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 470137009303 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 470137009304 benzoate transporter; Region: benE; TIGR00843 470137009305 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 470137009306 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 470137009307 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 470137009308 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 470137009309 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 470137009310 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 470137009311 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 470137009312 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 470137009313 23S rRNA binding site [nucleotide binding]; other site 470137009314 L21 binding site [polypeptide binding]; other site 470137009315 L13 binding site [polypeptide binding]; other site 470137009316 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 470137009317 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 470137009318 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 470137009319 dimer interface [polypeptide binding]; other site 470137009320 motif 1; other site 470137009321 active site 470137009322 motif 2; other site 470137009323 motif 3; other site 470137009324 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 470137009325 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 470137009326 putative tRNA-binding site [nucleotide binding]; other site 470137009327 B3/4 domain; Region: B3_4; pfam03483 470137009328 tRNA synthetase B5 domain; Region: B5; smart00874 470137009329 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 470137009330 dimer interface [polypeptide binding]; other site 470137009331 motif 1; other site 470137009332 motif 3; other site 470137009333 motif 2; other site 470137009334 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 470137009335 NAD-specific glutamate dehydrogenase; Region: NAD-GH; pfam10712 470137009336 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 470137009337 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 470137009338 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 470137009339 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 470137009340 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 470137009341 nucleotide binding site [chemical binding]; other site 470137009342 NEF interaction site [polypeptide binding]; other site 470137009343 SBD interface [polypeptide binding]; other site 470137009344 chaperone protein DnaJ; Provisional; Region: PRK10767 470137009345 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 470137009346 HSP70 interaction site [polypeptide binding]; other site 470137009347 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 470137009348 substrate binding site [polypeptide binding]; other site 470137009349 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 470137009350 Zn binding sites [ion binding]; other site 470137009351 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 470137009352 dimer interface [polypeptide binding]; other site 470137009353 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 470137009354 S-adenosylmethionine binding site [chemical binding]; other site 470137009355 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 470137009356 active site 470137009357 dimer interface [polypeptide binding]; other site 470137009358 Uncharacterized conserved protein [Function unknown]; Region: COG5470 470137009359 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 470137009360 glutathione synthetase; Provisional; Region: PRK05246 470137009361 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 470137009362 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 470137009363 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 470137009364 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 470137009365 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 470137009366 Walker A motif; other site 470137009367 ATP binding site [chemical binding]; other site 470137009368 Walker B motif; other site 470137009369 arginine finger; other site 470137009370 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 470137009371 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 470137009372 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 470137009373 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 470137009374 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 470137009375 PBP superfamily domain; Region: PBP_like_2; pfam12849 470137009376 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 470137009377 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 470137009378 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137009379 dimer interface [polypeptide binding]; other site 470137009380 conserved gate region; other site 470137009381 putative PBP binding loops; other site 470137009382 ABC-ATPase subunit interface; other site 470137009383 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 470137009384 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 470137009385 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 470137009386 dimer interface [polypeptide binding]; other site 470137009387 conserved gate region; other site 470137009388 putative PBP binding loops; other site 470137009389 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 470137009390 ABC-ATPase subunit interface; other site 470137009391 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 470137009392 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 470137009393 Walker A/P-loop; other site 470137009394 ATP binding site [chemical binding]; other site 470137009395 Q-loop/lid; other site 470137009396 ABC transporter signature motif; other site 470137009397 Walker B; other site 470137009398 D-loop; other site 470137009399 H-loop/switch region; other site 470137009400 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 470137009401 PhoU domain; Region: PhoU; pfam01895 470137009402 PhoU domain; Region: PhoU; pfam01895 470137009403 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 470137009404 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 470137009405 active site 470137009406 phosphorylation site [posttranslational modification] 470137009407 intermolecular recognition site; other site 470137009408 dimerization interface [polypeptide binding]; other site 470137009409 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 470137009410 DNA binding site [nucleotide binding] 470137009411 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 470137009412 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 470137009413 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 470137009414 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 470137009415 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 470137009416 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 470137009417 dimerization interface [polypeptide binding]; other site 470137009418 DPS ferroxidase diiron center [ion binding]; other site 470137009419 ion pore; other site 470137009420 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 470137009421 Glycoprotease family; Region: Peptidase_M22; pfam00814 470137009422 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 470137009423 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 470137009424 Coenzyme A binding pocket [chemical binding]; other site 470137009425 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 470137009426 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 470137009427 putative acyl-acceptor binding pocket; other site 470137009428 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 470137009429 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 470137009430 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 470137009431 FeS/SAM binding site; other site 470137009432 TRAM domain; Region: TRAM; cl01282 470137009433 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 470137009434 PhoH-like protein; Region: PhoH; pfam02562 470137009435 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 470137009436 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 470137009437 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 470137009438 Transporter associated domain; Region: CorC_HlyC; smart01091 470137009439 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 470137009440 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 470137009441 putative active site [active] 470137009442 catalytic triad [active] 470137009443 putative dimer interface [polypeptide binding]; other site 470137009444 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 470137009445 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 470137009446 non-specific DNA binding site [nucleotide binding]; other site 470137009447 salt bridge; other site 470137009448 sequence-specific DNA binding site [nucleotide binding]; other site 470137009449 S-adenosylmethionine synthetase; Validated; Region: PRK05250 470137009450 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 470137009451 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 470137009452 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 470137009453 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 470137009454 ribosome maturation protein RimP; Reviewed; Region: PRK00092 470137009455 Sm and related proteins; Region: Sm_like; cl00259 470137009456 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 470137009457 putative oligomer interface [polypeptide binding]; other site 470137009458 putative RNA binding site [nucleotide binding]; other site 470137009459 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 470137009460 NusA N-terminal domain; Region: NusA_N; pfam08529 470137009461 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 470137009462 RNA binding site [nucleotide binding]; other site 470137009463 homodimer interface [polypeptide binding]; other site 470137009464 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 470137009465 G-X-X-G motif; other site 470137009466 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 470137009467 G-X-X-G motif; other site 470137009468 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 470137009469 hypothetical protein; Provisional; Region: PRK09190 470137009470 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 470137009471 putative RNA binding cleft [nucleotide binding]; other site 470137009472 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 470137009473 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 470137009474 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 470137009475 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 470137009476 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 470137009477 G1 box; other site 470137009478 putative GEF interaction site [polypeptide binding]; other site 470137009479 GTP/Mg2+ binding site [chemical binding]; other site 470137009480 Switch I region; other site 470137009481 G2 box; other site 470137009482 G3 box; other site 470137009483 Switch II region; other site 470137009484 G4 box; other site 470137009485 G5 box; other site 470137009486 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 470137009487 Translation-initiation factor 2; Region: IF-2; pfam11987 470137009488 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 470137009489 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 470137009490 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 470137009491 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 470137009492 RNA binding site [nucleotide binding]; other site 470137009493 active site 470137009494 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 470137009495 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 470137009496 16S/18S rRNA binding site [nucleotide binding]; other site 470137009497 S13e-L30e interaction site [polypeptide binding]; other site 470137009498 25S rRNA binding site [nucleotide binding]; other site 470137009499 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 470137009500 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 470137009501 RNase E interface [polypeptide binding]; other site 470137009502 trimer interface [polypeptide binding]; other site 470137009503 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 470137009504 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 470137009505 RNase E interface [polypeptide binding]; other site 470137009506 trimer interface [polypeptide binding]; other site 470137009507 active site 470137009508 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 470137009509 putative nucleic acid binding region [nucleotide binding]; other site 470137009510 G-X-X-G motif; other site 470137009511 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 470137009512 RNA binding site [nucleotide binding]; other site 470137009513 domain interface; other site 470137009514 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 470137009515 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 470137009516 S-adenosylmethionine binding site [chemical binding]; other site 470137009517 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505 470137009518 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 470137009519 NAD binding site [chemical binding]; other site 470137009520 homotetramer interface [polypeptide binding]; other site 470137009521 homodimer interface [polypeptide binding]; other site 470137009522 substrate binding site [chemical binding]; other site 470137009523 active site 470137009524 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 470137009525 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 470137009526 dimer interface [polypeptide binding]; other site 470137009527 active site 470137009528 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 470137009529 active site 1 [active] 470137009530 dimer interface [polypeptide binding]; other site 470137009531 active site 2 [active] 470137009532 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 470137009533 metal binding site 2 [ion binding]; metal-binding site 470137009534 putative DNA binding helix; other site 470137009535 metal binding site 1 [ion binding]; metal-binding site 470137009536 dimer interface [polypeptide binding]; other site 470137009537 structural Zn2+ binding site [ion binding]; other site 470137009538 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 470137009539 Bacterial SH3 domain; Region: SH3_4; pfam06347 470137009540 Bacterial SH3 domain; Region: SH3_4; pfam06347 470137009541 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 470137009542 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 470137009543 dimerization interface [polypeptide binding]; other site 470137009544 ligand binding site [chemical binding]; other site 470137009545 NADP binding site [chemical binding]; other site 470137009546 catalytic site [active] 470137009547 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 470137009548 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 470137009549 NlpC/P60 family; Region: NLPC_P60; cl17555 470137009550 Transcriptional regulators [Transcription]; Region: MarR; COG1846 470137009551 MarR family; Region: MarR; pfam01047 470137009552 multifunctional aminopeptidase A; Provisional; Region: PRK00913 470137009553 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 470137009554 interface (dimer of trimers) [polypeptide binding]; other site 470137009555 Substrate-binding/catalytic site; other site 470137009556 Zn-binding sites [ion binding]; other site 470137009557 Flp/Fap pilin component; Region: Flp_Fap; cl01585 470137009558 enoyl-CoA hydratase; Provisional; Region: PRK05862 470137009559 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 470137009560 substrate binding site [chemical binding]; other site 470137009561 oxyanion hole (OAH) forming residues; other site 470137009562 trimer interface [polypeptide binding]; other site 470137009563 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239